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No One UI 8.5 in April? Galaxy S25 update roadmap takes unexpected turn
It turns out that Samsung has no plans to roll out the Galaxy S25 family’s One UI 8.5 update in April. This isn’t an official confirmation or a leak, but a fact supported by evidence, suggesting a delay in the major update rollout. Samsung enthusiast Alfaturk discovered a potential April 2026 security update for the […]
DHS internal watchdog launches investigation into handling of contracts under Noem, Lewandowski
The Department of Homeland Security inspector general has launched a sprawling investigation into how contracts have been solicited and handled, including the involvement of former Secretary Kristi Noem and her de facto chief of staff Corey Lewandowski, according to two sources familiar with the probe.
On Trump’s Mind: Iran, Inflation and Sharpies
President Trump waxed on about the virtues of the pen, calling it more economical and a better instrument than the fancier writing tools preferred by his predecessors.
Ten Johns Hopkins researchers named American Association for the Advancement of Science Fellows
The 2025 class of American Association for the Advancement of Science fellows includes 449 scientists, engineers, and innovators spanning 24 scientific disciplines who are being recognized for their scientifically and socially distinguished achievements
How to Turn a Chicken Egg Into a Drug Factory
A biotech start-up is testing a novel way of efficiently producing pharmaceutical drugs.
An Indiana town shows two sides of Trump's factory "boom"
In industrial communities like South Bend, government policies are lifting some sectors while clouding the outlook for others, leaving many manufacturers navigating a patchwork of incentives, tariffs and shifting signals from Washington.
'This is our fight': Suburbanites embrace anti-Trump resistance ahead of No Kings protests
A growing faction of concerned citizens across America’s suburbs are positioned on the front lines of the anti-Trump resistance
Biotech Company Tivic Health Aims to Advance Immunotherapy Research Programs
Tivic Health Systems is developing immune‑modulating therapies for conditions, such as radiation exposure, while expanding biologics development and manufacturing capabilities.
Democracy Depends on Science—So Scientists Need to Show Up for Democracy
A shared commitment to facts and knowledge, produced independently from political interference, is critical to democracy—and worth fighting to protect.
Imaging manufacturer Guerbet faces financial challenges following recent FDA warning
Regulators recently scolded the France-based pharmaceutical firm for safety issues that occurred at its plant in Raleigh, North Carolina, which produces imaging contrast agents.
Caldara overlooked facts in slamming utilities
Normally, I appreciate the variety of perspectives published on Colorado Politics. But regarding Jon Caldara’s recent column on Xcel, he irresponsibly neglects key facts to the point of annihilating credibility (“Are our overlords normalizing power outages?” March 15). He neglects any discussion regarding the nuance of safety (or fiduciary responsibility) versus inconvenience, for example: Is […]
The real roadblock to government formation in Iraq isn’t Maliki—it’s Kurdish power politics
A dispute between Kurdish factions presents a significant structural obstacle to Iraq’s government formation regardless of who is nominated for prime minister.
New research sheds light on a common risk factor for colorectal cancer
New research clarifies the risk of colorectal cancer among people with Inflammatory Bowel Disease
Fact check: The lies Trump is using to sell his latest attack on mail-in voting
CNN debunks four of Trump’s most frequently repeated false claims about mail‑in voting.
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Subtle health changes may signal progressive supranuclear palsy years in advance
Drawing from UK Biobank data, Mass General Brigham researchers have uncovered specific health factors linked to higher or lower risk of developing progressive supranuclear palsy (PSP), a rare but devastating ...
U.S. Business Activity Hits 11-Month Low as War Drives Prices Higher
U.S. business activity growth slowed to an 11-month low in March while prices surged, according to a preliminary S&P Global survey released Tuesday. S&P’s composite output index, based on its surveys of services and manufacturing firms, fell to 51.4 from 51.9 in February. That was its weakest readi
Facts About Small Business: Family Farm Statistics 2026
Advocacy has released its newest infographic, spotlighting America’s family farms. About 86.5% of farms are small family farms. Small family farms generate 17.2% of agricultural production. Advocacy’s infographics use the most recent f
BIW strike comes weeks after visit by U.S. Defense Secretary Pete Hegseth
The strike arrives several weeks after a morale-boosting appearance in which U.S. Defense Secretary Pete Hegseth touted the need to boost defense manufacturing.
A three-generation store in business for 100 years is expanding in CT. Owner says they, ‘nailed it.’
The father-son business team says they plan to continue to grow, as “one of the satisfactions of our job is we’re helping people.”
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday.
Microsoft-backed startup raises $40 million for advanced chipmaking equipment tech
Lace, a Norway-headquartered chipmaking equipment startup which is backed by Microsoft, has raised $40 million in funding to further develop a technology that could enable significant advances in semiconductor design and manufacturing, the company said on Monday. To make cutting-edge chips, manufacturers such as Taiwan Semiconductor Manufacturing Co and Intel employ a process called lithography that uses light to draw complex circuits that form the foundation of advanced artificial intelligence chips. Manufacturers use light-based lithography systems made by the Dutch company ASML - which dominates the market - as they race to shrink chip components and squeeze in more features to boost the computing horsepower on a limited area of silicon.
Design Files: Mirrodin, Part 4
Mark finishes his trip through Mirrodin's design handoff file with a look at the set's rare artifacts and lands.
AMC Entertainment Holdings, Inc. (AMC) Is a Trending Stock: Facts to Know Before Betting on It
Zacks.com users have recently been watching AMC Entertainment (AMC) quite a bit. Thus, it is worth knowing the facts that could determine the stock's prospects.
A surprising foam discovery could change everyday products
Foams have long baffled scientists because liquid drains from them far sooner than theory predicts. New research shows the reason: the bubbles don’t stay put—they rearrange, opening pathways for liquid to escape. The key factor is the pressure needed to shift bubbles, not just push liquid through them. This insight reshapes how we understand foams and could improve everyday products.
Historical Wigan cotton mill to reopen as entertainment venue.
Factory Floor is set to open in Wigan's Grade II-listed Eckersley Mill following a £3m revamp.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
How “Feeling Over Facts” Reshaped American Politics—from Gingrich to Trump
There was a moment in the 2016 presidential campaign that, in retrospect, sounds less like campaign chatter than something a post-modern French philosopher might have slipped into American politics.
Elon Musk uveils moonshot Terafab project. Here are 4 takeaways.
Elon Musk said his Terafab project, a joint Tesla and SpaceX chip manufacturing initiative, will be needed to unlock a terawatt of AI computing power.
Health Literacy as a Modifiable Clinical Risk Factor: Operationalizing an Underrecognized Determinant of Outcomes
Health literacy has been considered a social determinant of health and has never been extensively incorporated in the general practice of clinical care. Systematic reviews and cohort studies sho...
Fact-checking Senate Minority Leader Chuck Schumer on the effects of the SAVE America Act
Senate Democratic Leader Chuck Schumer said the SAVE America Act would require in-person voter registration, “something only 5% of Americans do today." The act would require that, but the rate of in-person registrations is higher than Schumer said.
Gov. Stein announces $8.5 million for WNC small business recovery after Helene
The funding will assist 13 projects through the North Carolina Department of Commerce’s Small Business Infrastructure Grant Program, continuing the state’s response to the impacts of Hurricane Helene.
Scientists turn probiotic bacteria into tumor-hunting cancer killers
Scientists have engineered probiotic bacteria to act as tumor-seeking drug factories. In mice, these bacteria infiltrated tumors and produced a cancer-fighting drug right where it was needed. This targeted approach could make treatments more effective and reduce side effects. More research is needed before it can be tested in people.
Data Science Use Cases: 15 Real-World Applications Transforming Enterprise Operations
Explore 15 enterprise data science applications across manufacturing, healthcare, retail, and finance — with case studies, code examples, and proven outcomes.
Six avoidable factors that increase your risk of breast cancer
A healthy lifestyle without smoking, but with plenty of exercise and a healthy weight, can help avoid losing healthy years of life to breast cancer, the study led by UW scientists says.
Splenda manufacturer eyes $91M in upgrades to Indianapolis operations
Carmel-based Heartland Food Products Group plans to construct a new building and add the newly acquired Splenda brand to its product manufacturing operations in Indianapolis.
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Trump’s global agenda flies into domestic headwinds
Even as US President Donald Trump calls for international support for the war in Iran, within the US there are dissenting voices, as not everyone is convinced that war is the answer. What is clear is that domestic factors will increasingly limit Trump’s foreign policy and diplomatic engagement. Academic Derek Grossman discusses the issue.
Rep. Perry fact-checked on impact of lifting oil sanctions on Iran
Jeff Bezos aims to raise $100 billion to buy, revamp manufacturing firms with AI, WSJ reports
Jeff Bezos is in early discussions to raise $100 billion for a new fund that would acquire manufacturing companies and seek to use AI to drive and speed up automation, the Wall Street Journal reported on Thursday.
Google gives Android users a way to install unverified apps if they prove they really, really want to
: Chocolate Factory describes concession as an attempt to balance openess with safety
The best strength training plan might be simpler than you think
New strength training guidelines emphasize that doing any resistance training is what truly matters. Based on decades of research, experts say even simple routines can increase muscle, strength, and physical function. The key is not perfection but consistency. In fact, the best workout plan is the one you can maintain long term.
The Girl at the End of the World: A Gratitude Day Reflection on the Place that Built Our Science
⏱️ 9 min read | This Gratitude Day, March 23rd, we celebrate the extraordinary partnership between HD families, scientists, and caregivers, and reflect on the place that built the science on which we all stand.
Mississippi Cheese Straw Factory is closing. Store is sold out
The Mississippi Cheese Straw Factory is closing after the Yerger family announced their retirement. All products are now sold out.
DOE Announces $293 Million Genesis Mission Funding for Quantum Science and AI-Driven Research
DOE announces $293M Genesis Mission funding for AI-driven research in quantum information science, advanced manufacturing, biotechnology, and nuclear energy.
Alibaba AI Business Is ‘Free Call Option,’ First Eagle Fund Says
Alibaba Group Holdings Ltd.’s share price is only factoring in the company’s e-commerce business, not its artificial intelligence potential, says the manager of a $17 billion fund.
Issues & Ale: It's Just Politics
Join Michigan Public's Political Director Zoe Clark, Senior Capitol Correspondent Rick Pluta, and their FAQ Squad panelists as they give you the facts of the upcoming election cycle!
NN, Inc. Provides Update on Business Growth in the Data Center, AI Reasoning, and Cloud Computing Markets
CHARLOTTE, N.C., March 18, 2026 (GLOBE NEWSWIRE) -- NN, Inc. (“NN” or the “Company”) (NASDAQ: NNBR), a global diversified industrial company that engineers and manufactures high-precision components and assemblies with six sigma quality, today provided an update on its growing presence in the data center market, a key targeted growth market for the Company. NN has secured multiple new awards with a leading global provider of AI infrastructure and data center computing equipment. As this industry
Apple CEO Tim Cook doubles down on policy over politics while aligning with Trump’s manufacturing push
Apple CEO Tim Cook rejects any political labels while defending his close ties to the Trump administration amid criticism over his "Melania" documentary attendance.
TE Connectivity Acquires EV Charging Inlet Business From Phoenix Contact
TE Connectivity acquired a major portion of Phoenix Contact E-Mobility business, which manufactures charging inlets for electric vehicles.
Texas primary results showed limitations of polling
Many factors explain why pollsters face challenges in getting good sample sizes that truly reflect who is going to cast a ballot.
What a recent court win reveals about the Trump administration’s unlawful attacks on climate science
Recently released government documents show how the administration is seeking to replace scientific facts with propaganda and disinformation.
What to know about Bill Gates’ nuclear science company planned for the former South Philadelphia refinery site
TerraPower Isotopes will manufacture a rare, radioactive isotope for use in developing cancer treatments.
Judge upholds Apple delisting of free Musi app that streams songs from YouTube
Judge tosses Musi case against Apple, sanctions lawyers for "mak[ing] up facts."
Fact check: Trump’s barrage of false or unproven claims about the Iran war
President Donald Trump continues to make false and unproven claims about the war in Iran.
FNKO Q4 Deep Dive: Entertainment Slate and International Initiatives Guide 2026 Outlook
Pop culture collectibles manufacturer Funko (NASDAQ:FNKO) reported Q4 CY2025 results topping the market’s revenue expectations, but sales fell by 7% year on year to $273.1 million. Its non-GAAP profit of $0.05 per share was $0.02 above analysts’ consensus estimates.
PixlPay Announces Partnership with Factor4 to Expand Gift Card Solutions for Businesses
PixlPay, an Arkansas-based payment processing and point of sale solutions provider, has announced a new partnership with Factor4 to bring advanced gift card and loyalty technology to merchants across the United States.
Attaining Optimal Gut Health: Doctor Separates Facts From Myth
Dr. Roshini Raj, gastroenterologist at New York University Langone Medical Center, joins TODAY to talk about what’s best for your digestive and gut health. She also separates facts and fiction when it comes to lemon water detoxing your stomach, whether you can have too much fiber and more.
Factbox-Lawsuits Against Trump Administration's Health Policy Changes
March 16 (Reuters) - A federal judge on Monday blocked key parts of Health Secretary Robert F. Kennedy Jr.'s effort to reshape U.S. vaccine policy, including a move to reduce the number of shots routinely recommended for children. U.S. District Judge Brian Murphy in Boston sided with medical ...
Bleak Economic Indicators Add To Business Risk
Also in the Forbes CEO newsletter: How to ready manufacturing leaders for the future; Trump doubles down on Powell investigation; Atlassian lays off 10% of its workforce.
GE Aerospace to invest $12 million in Hooksett plant
GE Aerospace will invest more than $12 million into its site in Hooksett as part of a $1 billion investment into its U.S. manufacturing sites and suppliers this year.
The 7430U CPU scandal could spread: Another manufacturer under suspicion, ODM comes into the spotlight
While we recently found Chuwi guilty of CPU fraud twice, there are now indications that another Asia-based brand, Ninkear, could be affected. We also have a sample of this laptop at our disposal and are investigating immediately. Spoiler: The result exonerates the manufacturer, but raises questions about the original design manufacturer (ODM).
New Business: Robotics and AI rule at Hudson coffee drive-thru; new T-Bones open in Hudson
The best thing about the new coffee drive-thru in Hudson might be the fact there’s no need to scan QR codes or tip. That’s because behind the scenes robots are
Maine’s wild blueberries deliver more than tradition. Research proves they support health.
Wild blueberries — the iconic Maine crop dotting hillsides, decorating sweatshirts and adding personality to local menus — is more than a cultural symbol. Over 20 years of preclinical and clinical studies suggest that regularly consuming wild blueberries supports gut and heart health and may reduce risk factors associated with…
Worcester Six business park misses 5,000 new jobs target
Brexit and the pandemic are cited as factors behind the Worcester park not matching expectations.
US core capital goods orders unexpectedly flat in January
New orders for key U.S.-manufactured capital goods were unexpectedly unchanged in January and shipments of these products fell, pointing to weakness in business spending on equipment early in the first quarter.
Money, madness and the business of the bracket
Every March, millions of Americans convince themselves they can outsmart probability.They fill out a bracket, trust a hunch and watch the chaos unfold. What looks like a three-week basketball frenzy is in fact one of the most powerful business engines in American sports.
Surging Energy Costs Put German Industry ‘Really in Danger’
Four years after the Russian invasion of Ukraine sent energy prices soaring, the war in Iran is posing another challenge to efforts to revive European factories.
Anthropic's Claude Can Now Create Interactive Visuals Directly in Conversations
Anthropic's Claude chatbot has been updated with support for inline visual content that will help it provide clearer answers. Claude can now create custom visuals like charts, graphs, and diagrams. Visual content will be used when it better conveys an answer than plain text, and visual aids can also include real-world data like weather and recipes as long as web search is enabled. The visuals that Claude creates are distinct from Artifacts, and use HTML and SVG rather than image generation.
Scientists sound alarm over federal plan to dismantle vital weather and climate lab
Hopkins experts warn that dismantling its premiere weather-forecasting resource, NCAR, would leave us more vulnerable to the effects of extreme weather events
Davids Visits Merriam Manufacturer to Highlight Small Businesses Challenges
MERRIAM, KS – Today, Representative Sharice Davids visited K.C. Strings, the largest instrument string manufacturer in the state of Kansas, to see the company’s manufacturing operations and hear directly from the owners about their new ventures and the challenges they face due to chaotic federal policies set by the administration.
The 25 happiest cities in the US in 2026, ranked
A study compared 182 of the largest cities in the US on factors such as income, employment, health, and community data.
Manufacturers’ Q1 Survey: Trade Business Challenges Persist, but Optimism Up
Washington, D.C. – As the review of the United States–Mexico–Canada Agreement gets underway, a majority of manufacturers report they utilize either Canada or Mexico for critical parts of their supply chains—at a time when trade uncertainty remains manufacturers’ top business concern, according to the National Association of Manufacturers Q1 2026 Manufacturers’ Outlook Survey. The survey […]
Predictions, Odds, Analysis! UFC Vegas 114, X-Factor
This weekend (Sat., March 14, 2026), Ultimate Fighting Championship (UFC) will return home to the Meta APEX in Las Vegas Nevada, for UFC Vegas 114. Maybe this is the event that really turns things around and ends the UFC’s miserable 2026 start, but … probably not. Don’t get me wrong, Josh Emmett vs. Kevin Vallejos […]
Congressman Neal, BHS Talk Local Health Care in 2026
Congressman Neal says access to health care is also important as an economic factor in the area. PITTSFIELD, Mass. — In a time of federal funding uncertainties,...
Fact check: President Trump got these 17 things wrong in college sports summit
There's finally been time to digest all the wrong things President Trump said in his big meeting about college sports at the White House March 6.
LACLxS Work-in-Progress Seminar: The Politics of Everyday Conflict in Refugee Shelters
Fabricio Carrijo, a research affiliate at the Jagiellonian Centre for Migration Studies at Jagiellonian University, will give a talk titled "The Politics of Everyday Conflict in Refugee Shelters: Decolonial Perspectives from the Brazilian Amazon" for the Program in Latin American, Caribbean, and Latinx Studies.
ICYMI: NAM’s Jay Timmons, SBA Administrator Kelly Loeffler Join Fox Business to Discuss Inaugural Supplier Matchmaking Expo
Watch NAM’s Jay Timmons and SBA Administrator Kelly Loeffler on Fox Business Washington, D.C. – Today, the National Association of Manufacturers and the U.S. Small Business Administration host the inaugural 2026 Supplier Matchmaking Expo at Charlotte Motor Speedway in North Carolina. There, large manufacturers will connect with smaller suppliers, strengthening their U.S. supply chains and […]
Paramore—“Misery Business”
Imagine the angstiest, cringiest art you made as a teenager. Now imagine the entire world singing to it in their cars and at karaoke forever. Today, Rob is breaking down the emotionally turbulent emo-bop factory machine that is Paramore. He applauds the incredible and messy lyrics of ‘Riot!,’ which differentiate the album from those of similar bands of the time. Later, he talks to The Ringer’s Rob Mahoney, Paramore’s OG fan, to discuss the exponential improvement between ‘All We Know Is Falling’ and ‘Riot!’ and Hayley Williams’s incredible vocals on “Misery Business.”
Concrete sensor manufacturer Wavelogix receives $500K grant from National Science Foundation
WEST LAFAYETTE, Ind. — Wavelogix, a manufacturer of novel, patented concrete strength sensors invented at Purdue University’s College of Engineering, has received a $500,000…
CERN Science Gateway celebrates its 1000th science show
CERN Science Gateway has reached another milestone: the delivery of its 1000th science show! Since opening its doors in October 2023, Science Gateway has welcomed nearly 900 000 visitors of all ages to explore the fundamental questions of the Universe. Among its most popular activities are the science shows – dynamic, interactive demonstrations led by CERN guides and tailored to a broad audience of different age levels, including school groups, families and the general public. Designed to make complex scientific concepts accessible and entertaining, these live shows combine spectacular experiments, multimedia elements and audience participation. From the physics of particle collisions to the properties of superconductivity, electromagnetism and cryogenics, the science shows translate the research carried out at CERN into engaging visual experiences. Visitors might see superconductors levitate, follow particles through different detector layers or discover the beauty in phase transitions. Each demonstration is carefully crafted to spark curiosity while maintaining scientific accuracy. Members of the CERN community are of course warmly invited to visit CERN Science Gateway with their family or friends and attend one of the science shows. To register, please visit this page, and don’t forget to check the programme for the coming days. Become a CERN guide and run your own super-cool science show (and more)! To become a CERN guide, you can join the introduction course held every 3–4 weeks, which will give you an overview of what being a CERN guide entails. From there, further courses are available depending on what type of guide you would like to be. Because, of course, CERN guides are needed everywhere at CERN. If you imagine yourself as a more ‘traditional’ guide, you should know that there are currently more than ten exciting visit points in CERN’s visits portfolio, such as the Antimatter Factory, the ALICE experiment (surface), the Alpha Magnetic Spectrometer (AMS) control room, the ATLAS experiment (surface), the CERN Control Centre (CCC), the Data Centre, the LHCb experiment (surface), the Synchrocyclotron (SC), the SM18 test facility and the newly inaugurated Linac2 visit point. Indeed, CERN’s Visits Service and Visual Impact and Exhibitions Section recently collaborated on redesigning the Linac2 visit tour, which has just reopened to the public after several months of renovation work. The new tour offers visitors and guides alike an enriched, more immersive experience, designed to highlight the history and scientific significance of this major facility. So, fancy becoming one of the insiders? Join the introduction course, check the guides website or contact guides.manager@cern.ch. And remember, becoming a guide can benefit you, too.
RFK Jr.’s vaccine advisers drop proposal to revisit covid-19 shot
Some members of the CDC’s vaccine advisory panel have publicly questioned the safety and manufacturing of the shots, including raising a debunked theory that DNA contaminants in the vaccines are harmful.
Haleon Strengthens Commitment to China as Consumers Focus on Better Everyday Health
SHANGHAI, March 11, 2026--Haleon, a consumer company that is solely focused on better everyday health, is investing £65 million in a new state-of-the-art oral health manufacturing site in Shanghai. The facility will support the expansion of its oral care portfolio – which includes the global brands Sensodyne and parodontax – into China’s fast-growing tier 2 and tier 3 cities, where rising incomes, growing awareness of everyday health and a shift towards trusted, branded products are reshaping co
Fact-checking Trump's claim that Iran has Tomahawk missiles
Although a few countries other than the U.S. have Tomahawks, none of them is engaged in fighting Iran. Tomahawk cruise missiles are manufactured by Raytheon, a U.S. company, for use by the U.S. military and international partners.
When It Comes to Small Business Clients, Customer Experience is Everything
New research pinpoints client satisfaction as the most important driver of growth in business banking. Master the five key deliverables.
College Sports Commission CEO says system struggling with volume of ‘manufactured’ NIL deals
Some CFB deals guaranteed millions of dollars without having yet received approval through NIL Go, the clearinghouse used by the CSC.
Gemstone-filled river and striped mountain ridge form massive 'Y' in China's revitalized desert
A 2025 satellite photo shows a giant "Y" in the middle of the Taklamakan Desert, where a verdant river and a lengthy "red-white mountain" meet. The intersecting features are also home to an eighth-century fort that was chock-full of ancient artifacts.
Golf club firm owned by Trump’s sons merges with drone manufacturer
Merger to take drone firm public is latest business move by Eric Trump and Donald Trump Jr as father is in White House
Amazon Is Widening Its Sway Over the Freight Industry
The one-stop shop for handling freight and packages seems to be a thing of the past, with FedEx Corp. set to spin off its trucking business in June. United Parcel Service Inc. shed its trucking unit five years ago. Full-service brokerages can shepherd goods from the factory to a residential customer’s doorstep, but they do it by cobbling together transportation services of several providers.
No healthcare premiums? In this economy?! Here's how.
It turns out healthcare in America CAN be cheaper. If your employer wants it to be. Today on the show, we speak with a Canadian-founded startup that has unusually generous benefits for their employees. Come see Planet Money live on stage in April! 12 cities. Details and tix here: https://tix.to/pm-book-tour. Related episodes: Health insurance premiums are going up next year — unless you work at these companiesHealth care costs are soaring. Blame insurers, drug companies — and your employerThe hidden costs of healthcare churnFor sponsor-free episodes of The Indicator from Planet Money, subscribe to Planet Money+ via Apple Podcasts or at plus.npr.org. Fact-checking by Sierra Juarez. Music by Drop Electric. Find us: TikTok, Instagram, Facebook, Newsletter.
Magic handle Bucks to win 4th in a row
Speaking pregame ahead of Sunday’s contest between the Magic and Bucks, Orlando coach Jamahl Mosley pointed towards his team’s ability to set the tone early as a major factor behind Saturday’s win at Minnesota. One night later at Milwaukee, the Magic followed a similar recipe for success, scoring the first seven points of the game, limiting the Bucks to 15 points in the opening quarter and ...
How generational turnover and party switching reshape the US political map
Political polarisation has increased dramatically in the US in recent decades and is often linked to partisan geographic segregation. This column presents new evidence from 2008 to 2020 that reveals an increase in partisan segregation even at very local levels. However, while most studies focus on one explanatory factor, residential mobility, we find that generational change (in Democratic-trending areas) and Democrats leaving their party (in Republican-trending areas) explain a much larger share of the rise in partisan segregation.
Google Pixel 11 Pro XL: Case leak points to design change
Months before the expected launch of the Google Pixel 11 Pro XL, an accessory manufacturer lists a protective case for the next-generation flagship smartphone, providing first hints about a design change.
Apple planning new 3D-printed aluminum chassis for iPhone and Apple Watch: report
With the Apple Watch Ultra 3, Apple introduced a new 3D-printing manufacturing process for the titanium shell – allowing the...
Trump’s food industry friends are warning him RFK Jr.’s agenda is bad for business
Processed food manufacturers say there's a conflict between the Health secretary’s plans and Trump’s desire to rebuild factory towns.
Independence business opens health clinic for employees. See photos
Cabinetworks Group, the country’s largest privately owned cabinet manufacturer, opened a free health clinic for employees in Independence.
Independence business opens health clinic for employees. See photos
Cabinetworks Group, the country’s largest privately owned cabinet manufacturer, opened a free health clinic for employees in Independence.
Treasury Secretary Bessent forecasts largest bombing campaign yet, says Iran attempting 'economic chaos'
Treasury Secretary Scott Bessent said Iran fights on military and economic fronts as U.S. launches biggest bombing campaign against Iranian missile launchers and factories.
The true story of why Carolyn Bessette quit Calvin Klein — and how her relationship with JFK Jr. factored in
Episode 6 of FX's 'Love Story' depicts Carolyn Bessette's resignation from Calvin Klein. Here's what we know about why she really left the iconic fashion brand.