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Uncommon Ground seeks new operator as longtime Wrigleyville restaurateurs plan to retire
The longtime restaurateurs behind Uncommon Ground at 3800 N. Clark St. in Wrigleyville are seeking a new operator for the restaurant, brewery and music venue.
Brian Doherty, 57, Dies; Chronicled Libertarians and Other Outsiders
Fascinated by the fringes, he wrote a definitive history of libertarianism and books about underground comics and the Burning Man festival.
What’s the new 'Background Security' on the iPhone? What we know.
Apple's new Background Security Improvements operate between software updates, providing "lightweight security releases."
Microsoft Plans Better Windows 11 RAM Management and a Smoother User Experience
Microsoft recently announced a plethora of changes coming to Windows 11 to reshape the operating system into a completely stable and enjoyable experience. Today we learn that Microsoft plans a major background usage overhaul with future updates, focusing on RAM usage and overall memory management, s...
Sheffield business owners 'don't feel safe' next to illegal waste site
An Attercliffe dumping ground is identified as one of the worst in the country by the government.
Statue of Christopher Columbus installed on White House grounds
A statue of Christopher Columbus has been erected outside of an ornate federal office building on the White House grounds — the latest sign of the Trump administration’s efforts to reshape cultural and historical representations across the nation’s capital.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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The Trump administration's immigration crackdown in Minneapolis forced some families into hiding and catalyzed informal medical networks to deliver critical health care services inside homes.
Restaurant in 29 Palms says war in Iran has impacted its business
TWENTYNINE PALMS, Calif. (KESQ) – As the potential for an American ground invasion of Iran remains in question, uncertainty looms in the High Desert. The City of Twentynine Palms is closely intertwined with their Marine neighbors to the north, just five miles away from downtown. Among the people who live and work in the area,
Ubisoft's worst-kept secret is finally official as Assassin's Creed Black Flag Resynced artwork is revealed
Three years after reports of an Assassin's Creed Black Flag remake first surfaced, Ubisoft has finally made its worst-kept secret official.
Republicans hand Trump the wheel on Iran — but one red line emerges
GOP lawmakers signal support for ongoing missile strikes in Iran while drawing a firm red line at ground troops, insisting on Congress' constitutional authority over war.
'THE STORY OF EVERYTHING' PRESENTS GROUNDBREAKING EVIDENCE THAT HAS REIGNITED THE DEBATE OVER SCIENCE, ORIGINS, AND THE EXISTENCE OF GOD IN THEATRES NATIONWIDE FROM FATHOM ENTERTAINMENT APRIL 30-MAY 6
A new feature documentary is about to challenge everything you thought science had settled about the origin of the universe—and the existence of God. The Story of Everything arrives in theatres nationwide April 30–May 6 from Fathom Entertainment, the leading specialty distributor of content to theatrical partners worldwide. The Story of Everything will bring to the big screen stunning new evidence from cosmology, physics, and molecular biology that its creators say demands a radical rethinking o
We must close the 'shocking' knowledge gap in women's health
This International Women's Day, we should prioritise groundbreaking research into women's health, such as strengthening the reproductive system's natural defences, says Anita Zaidi
Flo Health Publishes Groundbreaking Research on Economic Impact of Digital Tools for Endometriosis Care
Peer-reviewed study finds Flo Health's Symptom Checker could deliver nearly $10,100 in net monetary benefit per patient while cutting diagnosis wait time in half NEW YORK CITY, NY / ACCESS Newswire / March 3, 2026 / Flo Health, the world's #1 women's ...
#dubai #expatexperience #dubailife #expat #expatcommunity
The thought of leaving Dubai fills Kiran Ali with dread. Ali, a Washington, DC, import, moved to Dubai in March 2024. Speaking to Business Insider on Tuesday, she said she'll only leave Dubai if it becomes dangerous for her two young kids. "Dubai is the most fulfilled and happy I have been in my adult life," she said. "I have an incredible career, a purpose in community organizing, and great work life balance." For more than two decades, Dubai has marketed itself as a safe haven for expats with zero income tax, high salaries, and a luxury lifestyle. But the US and Israel's strikes on Iran over the weekend have thrown the Middle East into turmoil and raised questions about Dubai's future as a business, tourism, and expat hub. Read more about how expats on the ground aren't giving up on their expat dream so easily on Business Insider: https://lnkd.in/eM_ARYRU (Credit: Getty Images) #dubai #expatexperience #dubailife #expat #expatcommunity
Kendall Qualls’ lieutenant governor pick misstates age, is opaque about business background
Kendall Qualls — the Army veteran and former health care executive running for the Republicans nomination for Minnesota governor — announced Tuesday that Brian Nicholson will be his running mate, though he offered scant biographical details about the man who would be a heartbeat from the governor’s office. Qualls finished second in the precinct caucus […]
Proactiv Entertainment
New branding and redefined values strengthen the company's global position in the live entertainment industry
Everton v Burnley: Key stats and talking points
Everton will be looking to arrest a sharp decline in their home form when Burnley make the relatively short trip to Hill Dickinson Stadium on Tuesday (19:30 GMT). The Toffees, who sit eighth, won five of the first nine league games at their new ground on the banks of the River Mersey, but they are winless in their past seven, their worst run at home since going nine without a victory at Goodison Park between April and October 1998. Back-to-back losses at home to Bournemouth and Manchester United were followed up by an impressive 3-2 win over Newcastle United in a lively game at St James' Park on Saturday.
Developer breaks ground on entertainment hub in Las Vegas’ historic Westside
A developer has broken ground on a new entertainment and community space in Las Vegas’ historic Westside, with a focus on local vendors and small business growth.
$275M sports complex breaks ground in Homestead
A $275 million sports complex in Homestead broke ground on Monday.
I found a Pixel camera feature that totally changed my photos — here's what it does
From concerts to candid portraits, Super Res Zoom on the Pixel lets you shoot like a pro
‘We’re going into a dark place’: Brit awards artists voice alarm over Reform UK’s rise
CMAT, Wolf Alice, Wet Leg, Self Esteem and Loyle Carner say musicians should not shy away from politics – with several warning of ‘scary times’ as the far right gains ground
10 Years of Building Business Dreams for Indigenous Women
Women travel from tribal communities across Arizona and the Southwest carrying business plans, lived experience and ambition. Project DreamCatcher is a free, culturally grounded business education pro...
Aurora says occupied areas of navigation campus tested safe for mold after health concerns raised
Health Ministry tells hospitals to move operations to protected and underground areas
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Rise Brands scraps plan to revive Bogey Inn site with entertainment campus
Plans to transform the historic Bogey Inn property into a sprawling entertainment campus are no longer moving forward.
Cullen a player who 'all the coaches love'
Liam Cullen is used to autographs, though usually he is the one holding the pen. It was a different story on Tuesday night, when Cullen scored a stoppage-time equaliser in Swansea City's draw with Preston North End and then received a pat on the back from Snoop Dogg. On Monday, the rap superstar and Swansea co-owner visited the club's training ground, where he printed his own 'Snoop Dogg' jersey with the number 20 on the back.
Scientists Are Setting Off Earthquakes. On Purpose.
At the Bedretto Underground Laboratory deep in the Swiss Alps, scientists are inducing tiny earthquakes along a natural fault zone in the hopes of understanding what can trigger—and prevent—a deadly earthquake.