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Results for " pro " 75,835 found 🔀 AI-powered Shuffle

What's fair game in politics?

Jim Lokay discusses the controversy over Vivek Ramaswamy's attack ad involving his opponent Amy Acton's estranged mother, plus how affordability arguments are shaping the last week of the midterm campaign with Andrew Donaldson of Ordinary Times.

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Oct 25 • 9:08 PM EDT • Politics • fox5dc.com
Trump critic Lula wins reelection in Brazil, securing fourth presidential term

Brazil’s President Luiz Inácio Lula da Silva, a vocal critic of President Donald Trump, has been reelected in a result that provides relief to critics of widening U.S. influence in

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Oct 25 • 8:58 PM EDT • Business • journalgazette.net
Jay-Z urges fans to 'question everything' during Los Angeles show

Jay-Z urged fans to "question everything" during his final 30th anniversary concert, warning them about the rise of AI and propaganda.

yahoo.com logo
Oct 25 • 8:56 PM EDT • Entertainment • yahoo.com
Ja'Marr Chase's "screaming" at halftime helped spark Bengals turnaround
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Oct 25 • 8:44 PM EDT • Sports • sports.yahoo.com
Politics Unplugged (Full Episode) Oct. 25, 2026

On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.

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Oct 25 • 8:31 PM EDT • Politics • azfamily.com
FL GOP Rep. Carlos Gimenez: I don’t want my children or grandchildren to face a nuclear Iran
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Oct 25 • 8:25 PM EDT • Politics • cnn.com
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Johnson County Focus on Youth Fund promotes access to children’s mental health resources

This is an installment of a series exploring youth mental health. The Daily Iowan has received a grant and is partnering with the Solutions Journalism Network to explore the topic. The Johnson County Focus on Youth Fund has been promoting access to children’s mental health resources by providing funding for families who can’t afford services....

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Oct 25 • 8:13 PM EDT • Health • dailyiowan.com
Innovative food processing technique boosts Nebraska companies, educational outreach

Leadership and strategic visioning by Mary-Grace Danao, research associate professor in the Department of Food Science and Technology and the Department of Biological Systems Engineering, has helped position the University of Nebraska–Lincoln at the forefront of high pressure processing-focused food safety research in partnership with private industry.

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Oct 25 • 8:00 PM EDT • Science • news.unl.edu
Preparing for what’s next: Nursing insights on Future Ready Healthcare

New 2026 survey findings reveal how nurses view workforce sustainability, AI adoption, and patient communication, offering practical insights into what it takes to build a future-ready healthcare organization.

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Oct 25 • 8:00 PM EDT • Health • wolterskluwer.com
Gauging Global Access to Dermatology Care: Q&A With Esther E. Freeman, MD

Dermatologist and epidemiologist Esther E. Freeman discusses the Global Access to Skin Health Observatory Study and how its findings will hopefully help improve dermatology care worldwide.

medscape.com logo
Oct 25 • 8:00 PM EDT • Health • medscape.com
Columbiana County Health District approve first reading of food service fees

LISBON — The proposed food service fees for next year through the Columbiana County Health District appear to be staying the same or decreasing from this year’s fees, with two more readings required for passage. The county health district board held first reading on the proposed fees on Wednesday, along with first reading on environmental […]

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Oct 25 • 8:00 PM EDT • Health • salemnews.net
Young Scientists Congress: New technologies take centerstage at science exhibition in Wenzhou

The World Young Scientists Congress has opened in Wenzhou, east China's Zhejiang Province. More than 800 scientists and entrepreneurs from over 60 countries and regions are attending the event which includes an exhibition of the latest technologies. We spoke with some of the visitors to the event.

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Oct 25 • 8:00 PM EDT • Science • news.cgtn.com
Autism study reveals neural circuit supporting flexible learning

Researchers have identified a brain circuit linked to the flexible formation of memories that may help explain some of the differences in learning associated with autism spectrum disorder.

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Oct 25 • 8:00 PM EDT • Science • science.anu.edu.au
Probi and Symrise spotlight new clinical evidence at SupplySide Global

At SupplySide Global 2026, Symrise and Probi present new clinical findings for skin radiance and digestive health alongside a stable probiotic designed to broaden formulation options for brands

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Oct 25 • 8:00 PM EDT • Health • nutraceuticalbusinessreview.com
Kenny Gainwell productive in Week 7

Buccaneers RB Kenny Gainwell played well with bigger workload in Week 7

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Oct 25 • 7:57 PM EDT • Sports • sports.yahoo.com
Lions beat Packers 20-17 on last-play field goal
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Oct 25 • 7:46 PM EDT • Sports • sports.yahoo.com
Zelenskyy says Putin’s statements on readiness for peace talks could be a ‘political trick’

Ukrainian president argues Russian intentions would become clear through its actions, readiness to reach agreements | Anadolu

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Oct 25 • 7:38 PM EDT • Politics • aa.com.tr
Kings’ Mogbo Wants To Set Defensive Tone in G League

Armed with a 7-foot-2 wingspan and relentless hustle, the two-way forward aims to spark Stockton’s defense through gritty rebounding and elite shot-contesting while eyeing a permanent NBA promotion.

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Oct 25 • 7:36 PM EDT • Sports • sports.yahoo.com
Thousands protest in Prague against public media funding reforms

Demonstrators allege Prime Minister Andrej Babis and his coalition's proposed reforms pose a threat to press freedom.

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Oct 25 • 7:29 PM EDT • Politics • aljazeera.com
Teddy Roosevelt Erred on Neanderthals

Just recently, paleontologists have found Neanderthal wooden tools (62-40 kya) preserved in stone.

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Oct 25 • 7:28 PM EDT • Science • scienceandculture.com
Vikings just proved why nobody wants to face Minnesota

The Minnesota Vikings have one real strength on their squad.

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Oct 25 • 7:15 PM EDT • Sports • sports.yahoo.com
Vucic Concedes Electoral Defeat, Setting Stage For New Era Of Serbian Politics, Relations With West

Aleksandar Vucic, Serbia's former president and dominant political figure for more than a decade, conceded defeat to the student-led protest movement in the country's parliamentary elections, potentially ushering in a new era of politics more closely aligned with Europe and away from the Kremlin.

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Oct 25 • 7:15 PM EDT • Politics • rferl.org
😐 Neutral (17%)
Aaron Jones will have an MRI on his knee
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Oct 25 • 7:14 PM EDT • Sports • sports.yahoo.com
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Most Windows users are seriously underusing this powerful desktop feature

Don't miss out on one of Windows' best multitasking and productivity features that gives you more room to work.

engadget.com logo
Oct 25 • 7:00 PM EDT • Technology • engadget.com
Some schools are banning caffeine pouches. Here's what parents and students should know

Young people are turning to caffeine pouches for a quick energy boost, raising concerns among health experts, school officials, and parents

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Oct 25 • 6:59 PM EDT • Health • gulfcoastnewsnow.com
Some schools are banning caffeine pouches. Here's what parents and students should know

Young people are turning to caffeine pouches for a quick energy boost, raising concerns among health experts, school officials, and parents

kcci.com logo
Oct 25 • 6:59 PM EDT • Health • kcci.com
Some schools are banning caffeine pouches. Here's what parents and students should know

Young people are turning to caffeine pouches for a quick energy boost, raising concerns among health experts, school officials, and parents

wbaltv.com logo
Oct 25 • 6:59 PM EDT • Health • wbaltv.com
Judges skeptical of Trump administration effort for force California to set aside mail ballots

A three-judge US Circuit Court of Appeals panel expressed significant skepticism Sunday over the Justice Department’s desire to inject itself into California’s midterm vote-counting process by forcing election officials to set aside the votes of suspected noncitizens who have been issued mail ballots.

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Oct 25 • 6:38 PM EDT • Politics • cnn.com
U2 Reflects on the Promise That Kept Them Together for 50 Years
yahoo.com logo
Oct 25 • 6:30 PM EDT • Entertainment • yahoo.com
12 Fun USB-C Gadgets For Your Home Office Desk

Some fun USB-C desk gadgets include the Dockcase Explorer Smart USB-C Hub, Raspberry Pi 500, Creative Pebble SE, Kodak Charmera, and the Divoom Ditoo Pro.

slashgear.com logo
Oct 25 • 6:30 PM EDT • Technology • slashgear.com
Veteran Makers Market highlights importance of supporting veteran-owned businesses

The Veteran Makers Market spotlights veteran-owned businesses, encouraging shoppers to support those turning military skills into local success.

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Oct 25 • 6:24 PM EDT • Business • wndu.com
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Sunday Sports: Section 3 football matchups announced and more

Here’s a recap of your North Country sports this Sunday.

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Oct 25 • 6:24 PM EDT • Sports • wwnytv.com
Serbia’s Vucic concedes defeat in seismic political shift

The long-serving strongman leader of Serbia, Aleksandar Vucic, has conceded defeat in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government

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Oct 25 • 6:11 PM EDT • Politics • latimes.com
A new state on the way? More Illinois counties could vote to leave Chicago behind

More than 30 counties have already approved the non-binding measure to leave Illinois

yahoo.com logo
Oct 25 • 6:06 PM EDT • Politics • yahoo.com
Walnut Ridge business starts coat drive for community

The Farm Service Tire Center in Walnut Ridge is hosting its first-ever coat drive, running now through Dec. 21.

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Oct 25 • 6:00 PM EDT • Business • kait8.com
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

The long-serving strongman leader of Serbia, Aleksandar Vucic, conceded defeat on Sunday in an election that pitted him and his right-wing party against a diverse student-led opposition movement that spent two years protesting his government.

cnn.com logo
Oct 25 • 5:50 PM EDT • Politics • cnn.com
Peoria business leader accused of DUI in deadly UTV crash

A business executive well known in the local sport community has been arrested on drunk driving accusations for a crash that killed a woman late Saturday night in rural Peoria County.

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Oct 25 • 5:48 PM EDT • Business • 25newsnow.com
Lawmakers propose $11M fix to restore school sports and activities funding

by Katie Klingsporn, WyoFile Wyoming’s new school funding model added more than $250 million in state education funding, including for widely supported

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Oct 25 • 5:45 PM EDT • Sports • capcity.news
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Missile makers see multi-year deals as politics-proof

Executives at the military’s biggest suppliers say the Pentagon’s new multi-year munitions deals are the surest way to navigate an uncertain funding climate.

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Oct 25 • 5:34 PM EDT • Politics • punchbowl.news
Novant Health hosting Hilton Head hiring event Oct. 28

Novant Health will host a healthcare hiring event Oct. 28 on Hilton Head Island for nursing, laboratory, pharmacy and other positions.

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Oct 25 • 5:22 PM EDT • Health • wtoc.com
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Cooper Health launches new mobile addiction and recovery program

The program will focus on high-need areas in the city and respond elsewhere when called, helping to connect people to addiction support services. | KYW Newsradio

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Oct 25 • 5:17 PM EDT • Health • audacy.com
😐 Neutral (0%)
Health West Chubbuck expands hours, adds X-ray services and two new providers

CHUBBUCK — Health West has announced that it has expanded the services offered at Health West Chubbuck and that it has added two new providers to its staff as well

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Oct 25 • 5:11 PM EDT • Health • idahostatejournal.com
Clemson’s Loss to Virginia Tech Puts the Program in Flux

Clemson’s loss to Virginia Tech puts the program in flux heading into November. The Tigers now find themselves on the outside looking in on the ACC Championship race after being defeated 20-16 by the Hokies. Dabo Swinney’s team played well in many spots, especially in the third quarter. The complementary football Clemson displayed to start the …

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Oct 25 • 5:05 PM EDT • Sports • sports.yahoo.com
Packers' top two centers are questionable to return
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Oct 25 • 4:59 PM EDT • Sports • sports.yahoo.com
British Columbia's new premier lucks into the job in unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

yahoo.com logo
Oct 25 • 4:58 PM EDT • Politics • yahoo.com
BC's new premier lucked into the job in an unexpected political turn

An electoral gamble by the Canadian province's outgoing premier, David Eby, backfired as the provincial Conservatives take power for the first time since 1928.

bbc.com logo
Oct 25 • 4:58 PM EDT • Politics • bbc.com
Presidential race in Bulgaria heads to runoff due to record low turnout

In a surprisingly strong performance, the candidate of the pro-Western reformist opposition, Andrey Gyurov, will face the incumbent leftist president, Iliana Yotova, setting clear lines of division regarding the country’s future relationships with other nations.

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Oct 25 • 4:39 PM EDT • Politics • pbs.org
Why Democrats see a path to victory in Mississippi midterm election
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Oct 25 • 4:30 PM EDT • Politics • cnn.com
😐 Neutral (0%)
Mobile County Health Department updates sentinel chicken test

It concerned testing for St. Louis encephalitis

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Oct 25 • 4:30 PM EDT • Health • fox10tv.com
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New Sistersville General Hospital marks milestone with final beam signing

Memorial Health System celebrated a milestone for the new Sistersville General Hospital with a final beam signing ahead of its 2027 opening, marking progress on expanded rural health care.

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Oct 25 • 4:17 PM EDT • Health • wtap.com
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6 Essential Gadgets For Learning To Play Guitar

We've picked out some of the best gadgets to support the process of learning to play the guitar, including for timing, ear training, and song practice.

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Oct 25 • 4:02 PM EDT • Technology • bgr.com
Bengals blank Ravens in second half, win 35-13
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Oct 25 • 4:01 PM EDT • Sports • sports.yahoo.com
How Pratt Proved Brewers Right in the World Series

Shrugging off an early error, rookie Cooper Pratt delivered a clutch game-winning hit, vindicating the Milwaukee Brewers long-term investment.

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Oct 25 • 4:00 PM EDT • Sports • sports.yahoo.com
NH candidates for governor, U.S. Senate, Congress clash over...

At a Manchester forum, New Hampshire candidates clashed over housing, energy, healthcare and other costs as affordability emerged as voters’ central concern. ...

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Oct 25 • 4:00 PM EDT • Politics • unionleader.com
French and Italian Retailers Tally Losses Ahead of Holiday Season

Retailers in France and Italy face financial losses and security concerns as protests disrupt business ahead of the holiday shopping season.

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Oct 25 • 3:57 PM EDT • Business • wwd.com
Photo: Jude Bellingham’s head-turning new boots for Barcelona showdown

Real Madrid star Jude Bellingham has on Sunday evening provided a look at the head-turning footwear that he is set to make use of in El Clásico.The latest edition of Spanish football’s most bitter ...

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Oct 25 • 3:45 PM EDT • Sports • sports.yahoo.com
Primark's Business Doesn't Make Sense

In a world where fast fashion giants like Shein, Zara, and H&M drop thousands of new styles every day — and rake in billions through e-commerce — Primark is doing the unthinkable: thriving with zero online shopping. So what gives?*Want to Know the 5 Trends Changing Modern Retail? Find Out Here:* 🔗 https://clickhubspot.com/d13ac2In this video, we take you inside Primark’s weirdly brilliant business model — a model that’s stuck in the past on purpose. From warehouse optimization and floor-ready freight shipments to why the pandemic didn’t push them online, we unpack how this low-cost retail giant has managed to defy digital norms… and make it work.This isn’t just about one brand. It’s a story about modern retail expectations — and what it actually takes to meet (or reject) them.Subscribe to The Hustle:🔗 https://clickhubspot.com/vu3lGet the 5-minute newsletter keeping 2M+ innovators in the loop🔗 https://clickhubspot.com/3klnAbout HubSpot: HubSpot is a customer platform that provides education, software, and support to help businesses grow better. The platform includes marketing, sales, service, commerce, operations, and website management products that start free and scale to meet our customers’ needs at any stage of growth. Today, thousands of customers around the world use HubSpot’s powerful and easy-to-use tools and apps to attract, engage, and delight customers.#TheHustle #HubSpot

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Oct 25 • 3:31 PM EDT • Business • finance.yahoo.com
Packers RG Kevin Zeitler inactive, with Aaron Banks active
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Oct 25 • 3:30 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-13%)
Retailers in Paris React to Protests [PHOTOS]

Retailers Assess Cost of Lost Business After Second Round of Protests

wwd.com logo
Oct 25 • 3:08 PM EDT • Business • wwd.com
🚨 Barcelona & Real Madrid name XIs for El Clásico

Barcelona and Real Madrid face off in El Clásico this evening. Hansi Flick's Barcelona top La Liga this season after winning all nine matches.Real Madrid will hope for improvements this evening as L...

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Oct 25 • 2:54 PM EDT • Sports • sports.yahoo.com
Nets' Second-Year G Dëmin Bounces Back Against Cavaliers

The Brooklyn Nets got a much-better performance from second-year BYU product Egor Dëmin against the Cleveland Cavaliers. With Mikel Brown Jr. on a minutes restriction, Dëmin needs to play a big role.

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Oct 25 • 2:49 PM EDT • Sports • sports.yahoo.com
Heidi Klum frightens fans, teases Halloween costume with bizarre close-up of strange prosthetic

The Queen of Halloween herself Heidi Klum is offering fans a first look at this year’s Halloween costume. As usual, it involves some pretty bizarre prosthetics.

ew.com logo
Oct 25 • 2:37 PM EDT • Entertainment • ew.com
49ers lead at halftime despite offense struggling without Christian McCaffrey
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Oct 25 • 2:30 PM EDT • Sports • sports.yahoo.com
Buccaneers blowing out Panthers with 33-6 halftime lead
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Oct 25 • 2:27 PM EDT • Sports • sports.yahoo.com
Top Japanese Prospect Has His Eyes on the Dodgers

The Los Angeles Dodgers are the industry favorite to sign the best prospect in Japan, 18-year old pitcher Shoki Oda.

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Oct 25 • 2:26 PM EDT • Sports • sports.yahoo.com
The Future of IBD Treatment: 4 Promising Therapies to Know About

New treatments are in development for inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. Find out what experts say you should know.

health.yahoo.com logo
Oct 25 • 2:21 PM EDT • Health • health.yahoo.com
Binaytara Implementation Science Research Awards 2027 - Oncology News, Insights, Stories by OncoDaily

The Binaytara Implementation Science Research Awards 2027 provide up to $25,000 per project to support early-career investigators improving how evidence-based

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Oct 25 • 2:15 PM EDT • Science • oncodaily.com
Windows 11 is apparently so bad that XBOX would rather cancel hardware than be forced to use the OS

A reported clash between Microsoft's XBOX and Windows teams suggests Windows 11's desktop may no longer be the foundation for Project Helix.

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Oct 25 • 2:14 PM EDT • Technology • windowscentral.com
Ramaswamy built his political career in NH. It's faltering in Ohio.

Many New Englanders remember Ramaswamy from his mad-dash presidential campaign in New Hampshire. Will his political career survive a tumultuous run for Ohio governor?

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Oct 25 • 2:13 PM EDT • Politics • bostonglobe.com
Scientists Develop a Clever New Way To Kill Cancer Cells From the Inside

Scientists have developed an experimental strategy that exploits a chemical byproduct of cancer cells to produce anticancer drugs directly inside them. Scientists in Japan have developed an experimental method that uses a chemical produced by cancer cells to manufacture anticancer drugs directly inside them. The approach relies on carbon monoxide, a toxic gas that certain

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Oct 25 • 1:45 PM EDT • Science • scitechdaily.com
Unpatched Tailscale SSH Flaws Could Let a Hacked Device Reach Root on Other Servers

Unpatched Tailscale SSH flaws could let attackers gain root on permitted servers from a compromised device when port forwarding is enabled.

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Oct 25 • 1:44 PM EDT • Technology • thehackernews.com
Professor Katherine McNeill Inducted Into Massachusetts Science Educators Hall of Fame

Katherine L. McNeill was inducted into the Massachusetts Science Educators Hall of Fame on Friday in recognition of her two decades of work in science education.

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Oct 25 • 1:33 PM EDT • Science • bcheights.com
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Projections for Cleveland Guardians’ Arbitration Eligible Players

The Cleveland Guardians have several key players arbitration-eligible this offseason.

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Oct 25 • 1:30 PM EDT • Sports • sports.yahoo.com
J.J. McCarthy, Giants take 7-3 lead on Texans
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Oct 25 • 1:29 PM EDT • Sports • sports.yahoo.com
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Elon Musk’s Grok Releases First AI-Generated “Odyssey” Episode

Months after Elon Musk promised that Grok Imagine would make an entirely AI “Odyssey” film, the tech mogul has partially followed through.

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Oct 25 • 1:22 PM EDT • Technology • variety.com
Scientists Discover How Excess RNA Can Disrupt the Energy Supply Inside Cells

Scientists at Texas A&M University discovered that excess RNA can interfere with the machinery cells use to produce energy, even without triggering certain immune defenses. The findings reveal an unex...

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Oct 25 • 1:19 PM EDT • Science • yahoo.com
The Making Of: Addams Family Values, Ocean Software's Attempt to Mix Hollywood & the Legend of Zelda

"Management didn't really understand development or the creative process"

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Oct 25 • 1:00 PM EDT • Technology • timeextension.com
Police: Lancaster County health care worker assaulted

Incident occurred at WellSpan Hospital in Ephrata Borough, according to police.

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Oct 25 • 12:42 PM EDT • Health • wgal.com
Jaylen Warren and the Steelers run over the Saints in Paris
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Oct 25 • 12:35 PM EDT • Sports • sports.yahoo.com
Orlando Science Center hosts Halloween party

Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.

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Oct 25 • 12:32 PM EDT • Science • wftv.com
11 Cool Mini-Gadgets You May Not Realize Exist

You probably weren’t looking for a remote-control paper plane or a $600 calculator. Fair enough. They exist anyway, and they’re weirdly hard to ignore.

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Oct 25 • 12:30 PM EDT • Technology • slashgear.com
Kansas at Duke: Exhibition OGT

Kansas basketball hopes to follow the football team with a win today. Yeah, this game doesn’t count, but any time you’re playing Duke you want to win. Plus, this exhibition game is a big enough deal that ESPN is broadcasting it live (probably because they know everyone else will be watching football. I’m probably going […]

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Oct 25 • 12:21 PM EDT • Sports • sports.yahoo.com
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One Of Steven Spielberg's Biggest Box Office Flops Is An Underrated Disney Movie

Steven Spielberg is one of the most prolific directors to still be working, and he's known for absolutely stunning films, but not every movie can be a hit.

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Oct 25 • 12:17 PM EDT • Entertainment • yahoo.com
Photographer and medical professionals connect science and art during panel discussion

In 2020, the world was put on hold because COVID-19 began claiming the lives of people all over the globe. When a vaccination for the illness was finally made public in 2021, being vaccinated became highly politicized. Instead of focusing on the emotional reactions that people had toward the vaccine, artist Linda Alterwitz was more...

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Oct 25 • 12:14 PM EDT • Science • thesunflower.com
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Lycia Lands a $317M IPO for Inflammation Drugs Based on Nobel Prize-Winning Science

Lycia Therapeutics’ protein-degrading drugs are based on the research of Carolyn Bertozzi, a Stanford chemistry professor and Nobel laureate. Lycia’s lead drug candidate is in development for food allergy, where it could compete against the blockbuster Roche drug Xolair.

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Oct 25 • 12:13 PM EDT • Science • medcitynews.com
Memorial Health celebrates staff with trunk-or-treat

Memorial Health went all out for its annual trunk-or-treat event, celebrating team members and their families.

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Oct 25 • 12:13 PM EDT • Health • kswo.com
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Bloomington business continues to blossom

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Oct 25 • 12:11 PM EDT • Business • insideindianabusiness.com
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3 comments | Progressive Democrats are closely watching four Senate...

Progressive Democrats are closely watching four Senate races in the upcoming midterm elections. Our politics reporter Kellen Browning explains why.

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Oct 25 • 12:07 PM EDT • Politics • facebook.com
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Data center boom sparks massive power line fights hundreds of miles away

In Cat Kemmerling’s dream, she and her husband Rob are sitting in their pickup truck on a cliff on their West Virginia farm, overlooking the Shenandoah River. The truck is falling backwards over the edge, into the abyss below.

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Oct 25 • 12:00 PM EDT • Politics • cnn.com
How the conservative Supreme Court has rewritten the rules for the midterms

Voters will pick the winners of next month’s midterm elections, but it is the conservative Supreme Court that has set the rules.

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John Sununu is running on his family’s legacy in New Hampshire. His brother is staying on the sidelines

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Oct 25 • 12:00 PM EDT • Politics • cnn.com
"It never was entertainment to us, ever. It was always something with a lot more importance and meaning." U2 reveal the unbroken promise that they made to one another as schoolboys in Ireland 50 years ago

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Oct 25 • 12:00 PM EDT • Entertainment • loudersound.com
Americans have a grief problem we still call a mental health problem

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Oct 25 • 12:00 PM EDT • Health • yourvalley.net
RJW Logistics to open second Northwest Arkansas office

Chicago-based RJW Logistics Group, which has a Bentonville office, plans to open an additional Northwest Arkansas office amid client growth and to support demand for a new logistics program offered...

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Oct 25 • 11:55 AM EDT • Business • talkbusiness.net
2 political experts question Chicago Mayor Brandon Johnson's tax proposals for 2027 budget
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Oct 25 • 11:55 AM EDT • Politics • cbsnews.com
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Obama and Trump wage one last battle for even more urgent stakes

Two decades ago, Barack Obama stormed battleground states rebuking a Republican president over a deeply unpopular war and an economy that was crushing working Americans.

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Oct 25 • 11:45 AM EDT • Politics • cnn.com
Chair of 'submarine affair' committee probing Netanyahu resigns due to health concerns

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Oct 25 • 11:42 AM EDT • Health • haaretz.com
How Braves should handle $42 million Jurickson Profar situation

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Oct 25 • 11:36 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.

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Oct 25 • 11:27 AM EDT • Health • wpxi.com