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How a month of war on Iran has remade the world economy
The US and Israeli war on Iran is now a month old. In 30 days, the war has upended the world economy, affecting oil prices, markets, and travel.
The longest boxing match on record took place in New Orleans in 1893. It ended with no winner.
“The New Orleans of today holds no more fame than the New Orleans of yesteryear. For it was here that some of the world’s sport celebrities have performed.”
Science Central unveils new planetarium
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FULL SHOW: Inside INdiana Business 3/29/26
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Elegance and legacy meet at the Oroville Inn
If the walls at the Oroville Inn could talk, they’d regale listeners with stories of a booming hotel where locals and visitors attended elegant social events and the rich and famous — including former presidents Herbert Hoover and Ro…
Ben McCollum's winning legacy continues with Iowa's March Madness run
Though the stage keeps getting bigger, coach Ben McCollum continues to prove he’s a winner. McCollum and Iowa’s underdog March Madness run ended with a loss to Illinois on Saturday, but his success in his first season with the Hawkeyes proved he can win at any level. McCollum won four Division II national titles at Northwest Missouri State before spending one season at Drake.
Rutgers women’s lacrosse handles business against USC for second straight win
The Rutgers women’s lacrosse team defeated USC 15-8 for its second consecutive Big Ten win. The Scarlet Knights (7-4, 2-1) rode the momentum of a dominant 7-0 stretch in the first half and fended off multiple comeback attempts by the Trojans (6-7, 0-5) to secure the road victory.
Lakers guard Doncic gets one-game ban for accumulated technicals
Los Angeles Lakers guard Luka Doncic, the NBA scoring leader, was suspended one game without pay by the league on Saturday after receiving his 16th technical foul of the season.NBA rules require any player or coach be automatically suspended for one game once he is whistled for his 16th technical foul during a regular season.
Luka Dončić suspended 1 game after 16th technical foul of season
Happy Valley Rewind: Penn State-Iowa 2017
We continue our “Happy Valley Rewind” series by looking back at a spectacular Saquon Barkley game that ended with the heroics of Trace McSorley and Juwan Johnson. The full game can be viewed here:
BERRY: Nebraska’s season ends in heartbreak fashion
After a memorable season spanning four months and 28 days, highlighted by 28 wins, only seven losses, broken records, flu games and infinite memories, Nebraska’s historic 2025-26 season ended in Houston on Thursday night.
Another PlayStation price hike means the gaming console will cost 30% more than it did last year
The price of a PlayStation is going up by another $100, the second time in less than a year that Sony has upped the price tag on its popular gaming console. Global trade has been upended by U.S....
Why did Microsoft end 'This is an Xbox' marketing? Microsoft responds — "It didn't feel like Xbox."
Microsoft's controversial Xbox marketing campaign "This is an Xbox" was almost immediately ended after new CEO Asha Sharma came on board. Here's why.
Kings Shutout Canucks For Bounce-Back Victory
The Kings ended their poor week on a high note with a dominating win over the Canucks.
Oregon business leaders urge Gov. Kotek to think bigger with prosperity council effort
In a letter, the business leaders ended up laying out several priority areas but offered few specific proposals.
Christian Ulvert, EDGE Communications nab national award for Eileen Higgins’ Miami Mayor campaign
The win highlights a campaign operation that blended field, messaging and media into a cohesive strategy that resonated across Miami’s diverse electorate.
Opioid settlement funds designated to build 60-bed youth behavioral health facility in Anderson
The local nonprofit Family Dynamics Resource Center asked the county board for $2 million as a community match in order to receive $25 million dollars in funding from the state. The funds are intended to allow the organization, which provides counseling and parenting services, to develop a 60-bed behavioral health campus for youth.
Lynn sports management students attend National Football League Combine
Lynn University sports management students attended the Sports Management Worldwide National Football League (NFL) Combine Football Career Conference in…
New KFF Tracking Poll on Health Information and Trust Finds One in Three Adults Have Used AI Chatbots for Health Advice — The Monitor
KFF's latest Tracking Poll finds that one-third of the public report using AI chatbots for health information and advice in the past year. And a federal judge suspended, for now, the appointments of thirteen members of ACIP, halting a scheduled meeting and staying recent, widely debated, changes to the childhood vaccine schedule.
Politicians are trying to make life cheaper. Economists are appalled.
Both Republicans and Democrats are pitching ideas intended to address affordability, but experts warn the proposals could cause other problems.
New studies of old dogs help scientists understand where they came from
Using the oldest dog genes studied so far, scientists are finding more evidence that our furry friends have been our companions for thousands of years. Scientists think dogs descended from an ancient...
Afeela EVs Really Are Vaporware. Sony, Honda Kill Entertainment-Focused Car
Sony's plans depended on technology from three upcoming Honda models. When Honda cancelled those EVs, Sony did 'not have a viable path forward' on Afeela.
Le Bris 'at his brilliant best' to mastermind derby win
Leading up to Sunday's derby at Newcastle, all the talk centred around which of our injured players might be available and it ended up becoming a bit of a distraction from what was actually important - the players who were definitely fit to play their part. While I'm sure Regis le Bris would have loved a fully fit squad, he is not daft enough to get too distracted by the possibilities of having several of his walking wounded involved at the last minute. It meant that while Newcastle were distracted by European football, we were on the training ground figuring out how we were going to walk away from St James' Park with three points.
Florida company suspended over ‘threat’ to public health and welfare
The company handled claims for Medicare Advantage patients, many of whom have chronic or special needs.
76ers' Paul George blamed mental health for banned substance use
The Sixers' Paul George, who was suspended 25 games for a failed drug test, is set to return Wednesday when Philadelphia faces the Boston Celtics.
Delta suspends VIP services for Congress members amid DHS shutdown, TSA delays
Delta suspended VIP congressional services amid the government shutdown, telling lawmakers they'll be treated like regular travelers by SkyMiles status.
Why going to an HBCU might be better for Black students’ health
A study found correlation between the environment and long-term wellness in sample of 1,978 who attended college between 1940-80
2025 extended Session cost Florida taxpayers more than $259K
And there's plenty of extra work to do this year.
Extendend interview: Dr Roham Alvandi on Iran, Britain, and the futures that might have been
From Cold War power games to the cultural aspirations of the Pahlavi era, this extended conversation pulls back the curtain on the global forces that continue to shape - and be shaped by - Iran today. Dr Roham Alvandi is Director of the Iranian History Initiative at the London School of Economics and Political Science.
French Local Elections Are Yardstick for Far Right. Initial Results Are Mixed.
France’s municipal elections ended on Sunday evening. Full results were not expected for hours, but the first projections suggested the far right may not have made major gains.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Nashormeh N. R. Lindo wears colorful dress to Oscars after-party
Lindo attended the after-party with her husband and supporting actor nominee for "Sinners," Delroy Lindo.
Can future astronauts be put into comas for space travel like in Project Hail Mary?
The science-fiction film Project Hail Mary sees Ryan Gosling go to space in a state of suspended animation. But does the science suggest that’s possible?
Anders Lee defends Islanders’ effort after blowout Canadiens loss
New York Islanders captain Anders Lee defended his team's effort after a blowout loss on the road against the Montreal Canadiens.
New Research Shows the 6 Skills You Need to Master Anything
Scientists explain why some of us benefit more than others from expert guidance.
Kaiser Health Care unions ratify new contracts
LOS ANGELES, Cali. (KESQ) — After months of negations, including multiple strikes, UNAC/UHCP health care professionals have voted to ratify new contracts with Kaiser Permanente. During this negotiation period, union members walked off the job in January in what became the longest open-ended strike by nurses and health care professionals in U.S. history, lasting nearly
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Excess Heat Raises Tijuana River Valley Hydrogen Sulfide Emissions, Health Precautions Recommended
People in the South Bay, especially those living near the Tijuana River Valley (TJRV), are experiencing elevated hydrogen sulfide (H2S) emissions, often recognized by a strong rotten egg smell.
Reform UK suspends Scottish candidate less than a day after announcing him
Stuart Niven suspended after it emerged he had been struck off as a company director over financial allegations
Political tug of war over Iranian women's soccer team prompts criticism in Australia
The United States and Australia’s political tug of war against Iran over the fates of seven members of the Iranian women’s soccer squad who were torn in between appears to have ended
Political tug of war over Iranian women's soccer team prompts criticism in Australia
MELBOURNE, Australia (AP) — The United States and Australia’s political tug of war against Iran over the fates of seven members of the Iranian women’s soccer squad appears to have ended with the depleted team returning home minus the two players who defected last week.
AI is changing the style and substance of human writing, study finds
Teams from Google and leading universities found that large-language models change the voice, tone and intended meaning of human authors.
Crimson Desert Day One Update Goes Live in Full on PC, in Part on Console — Check Out the Patch Notes
Crimson Desert has launched across all platforms, and with it comes a day one update that makes some significant improvements to the game, some balance changes, and various fixes. Pearl Abyss recommended players download the patch “for the best experience.” Check out the patch notes.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Curis Provides Fourth Quarter 2025 Business Update
Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of emavusertib (CA-4948), an orally available, small molecule IRAK4 and FLT3 inhibitor, today reported its business update and financial results for the quarter ended December 31, 2025.
Earthquake scientists reveal how overplowing weakens soil at experimental farm
Plowing, or tilling, is an age-old agricultural practice that readies the soil for planting by turning over the top layer to expose fresh earth. The method—intended to improve water and nutrient circulation—remains ...
Accenture Collaborates with Microsoft to Bring Agentic Security and Business Resilience to the Front Lines of Cyber Defense
NEW YORK, March 19, 2026--Accenture today announced new assets and capabilities for its Adaptive Managed Extended Detection and Response (MxDR).
Russia adds fiber-optic wires to Molniya drones, makes them unjammable
Fiber-optic cables have typically been used for smaller quadcopters. Now, the practice is being extended to larger fixed-wing drones.
Whitworth’s Business Program Earns AACSB Accreditation Extension
Whitworth University is proud to announce the Association to Advance Collegiate Schools of Business (AACSB) has extended accreditation for t...
Accenture Reports Second-Quarter Fiscal 2026 Results
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US politicians attend event to celebrate links to Northern Ireland
More than 200 people attended the event organised by Communities Minister Gordon Lyons.
Sandhills Calving System continues to protect calf health, ranch profitability
Twenty-five years ago, a collaboration between a Sandhills ranch family, a rural veterinarian and Husker researchers led to a management innovation that transformed how cattle producers prevent calf scours. Known today as the Sandhills Calving System, the approach has become one of the most widely recommended strategies for preventing neonatal calf diarrhea.
25 Years of Courage and Curiosity: Sally Ride Science at UC San Diego Division of Extended Studies
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The heart health steps now recommended you take in your 20s and 30s
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China targets measurement science in tech race with U.S. - Futura-Sciences
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These 5 states still penalize you if you don't have health insurance
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Swatch Warns Political, Economic Challenges to Continue in 2026
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Jersey students call for 'a more political curriculum'
A number of students attended a debate in the States chamber.
Deputy AG Blanche defends DOJ’s work on Epstein case ahead of closed-door Hill briefing
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NASCAR driver Daniel Dye suspended for David Malukas comments
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Mamdani extends olive branch to Catholic New Yorkers
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Cibus Reports Fourth Quarter Financial Results and Provides Business Update
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Senate kicks off marathon debate over Trump’s voter ID bill
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We Saw Starfield's Big Overhaul and DLC - Is It Enough to Revive Bethesda's Space RPG?
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Judge blocks Kennedy's changes to US childhood vaccine schedule
Kennedy had slashed the number of recommended vaccines from 17 to 11, sparking a backlash from health experts.
Samsung stops selling $2,899 TriFold phone after just three months
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Bicycle Therapeutics Reports Recent Business Progress and Fourth Quarter and Full Year 2025 Financial Results
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Morning Sports: March 17, 2026
Sheridan HS Boys Basketball: It takes a team effort to win a state championship in a team sport such as basketball. Twenty-three different teams wore Sheridan Bronc jerseys since SHS last won a boys basketball state championship in 2003 and this year’s team put it all together and ended the slump. Head Coach Jeff Martini […]
Tencent Music Entertainment Group Announces Fourth Quarter and Full-Year 2025 Unaudited Financial Results
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Samsung to Stop Selling $2,899 TriFold Phone After Three Months
Samsung Electronics Co. is winding down sales of its Galaxy Z TriFold smartphone after roughly three months on the market, suggesting the $2,899 device was always intended as more of a technological showcase than a cornerstone of the company’s mobile lineup.
Suspended: Bayern Munich’s Nicolas Jackson handed two-game ban
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Federal judge halts RFK Jr.'s changes to children's vaccine policies
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Judge blocks RFK Jr. from scaling back childhood vaccine recommendations
A federal judge on Monday temporarily blocked federal health officials from cutting the number of vaccines recommended for every child, and said U.S. Health Secretary Robert F. Kennedy Jr. likely violated federal procedures in revamping a key vaccine advisory committee.
Legislative session ends with unfinished business, including budget
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Factbox-Lawsuits Against Trump Administration's Health Policy Changes
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Judge delivers bombshell order for Krafton to reinstate fired Subnautica 2 devs and CEO, putting $250m bonus package back on the table
A judge has ruled that fired Subnautica 2 leads including the former Unknown Worlds CEO must be reinstated, with their $250m bonus package extended.
Partisanship and science
I recently participated in a symposium of the Denver-based Institute for Science & Policy, during which I had a “fireside chat” with Tony Mills of the American Enterprise Institute. Mills has written extensively on the politicization of science, and the two of us had a very enjoyable hour-long conversation on the topic. You can watch it below. The main questions we dealt with are why there is such a vast partisan gap in trust of science, and to what extent this is a unique moment. Mills helpfully brings a good deal of data to the discussion, as he did in this useful piece at Issues in Science & Technology. Tusk depends on reader support. To support this work, please become a paid subscriber. Subscribe Note this graph, drawing on a range of survey data to demonstrate partisan attitudes toward science since 1970s. As it demonstrates, there’s been a very sharp partisan divergence in confidence in science during the Trump Era, starting prior to the Covid pandemic. At least in part, we can attribute this to a rise in populist anti-science rhetoric embraced by Trump, his appointees, and those in his media orbit. But as the graph also shows, the partisan divide has existed in the past, and it’s not always in the same direction. The largest divergence in party views toward science prior to 2016 was in the 1970s, when liberals equated scientific achievement with the military-industrial complex and thus trusted it less. That era of scientific mistrust is often overlooked. Indeed, as Mills notes, the Moon landings (1969-72), which today are considered one of the last great moments of national unity, were experienced nothing like that at the time. There was sharp debate back then over whether the Apollo missions were worth the vast expenditures when the country had so much else to deal with. It’s outside the dataset, and we don’t have the partisanship lens for it, but the 1950s was another deeply anti-science decade, with critics of intellectuals and college professors alleging their ties to communism and their lack of commitment to basic American moral beliefs. This was the subject of Richard Hofstadter’s 1962 book Anti-Intellectualism in American Life, in which he quotes religious leaders like Franklin Graham: [In place of the Bible] we substituted reason, rationalism, mind culture, science worship, the working power of government, Freudianism, naturalism, humanism, behaviorism, positivism, materialism, and idealism. [This is the work of] so-called intellectuals. Thousands of these “intellectuals” have publicly stated that morality is relative—that there is no norm or absolute standard.… This fervor was heavily whipped up by Sen. Joe McCarthy (R-Wisconsin), although it’s clear that not all his fellow Republicans were on board with his red-baiting. What ended that era? The simple answer is the 1957 launch of Sputnik. Americans became afraid that they were losing to Soviet scientists, and suddenly university researchers and government projects were awash with funding. In our conversation, I asked Mills about the possibility of us having a Sputnik moment again that would rally the American public in favor of science today. Mills argued that the COVID-19 pandemic was essentially a Sputnik moment — a terrifying threat to all Americans that required scientific advances to address. But thanks in part to political polarization and the populist and conspiratorial leanings of Donald Trump, we got the opposite of a unifying moment. Many Americans turned against science, despite science actually stepping up in that moment. As we discussed in the chat, it’s not clear what scientists could or should be doing in this moment to increase faith in their work. As Mills notes, one of the chief complaints against scientists and professors is that they’ve become too political; scholars becoming even more political might not help them achieve their goals. This (mainly Republican-driven) anti-science era will end, of course, but it’s not clear what event will bring that about. Share
Alto Neuroscience Reports Full Year 2025 Financial Results and Recent Business Highlights
MOUNTAIN VIEW, Calif., March 16, 2026--Alto Neuroscience, Inc. ("Alto") (NYSE: ANRO), a clinical-stage biopharmaceutical company focused on the development of novel precision medicines for neuropsychiatric disorders, today reported financial results for the full year ended December 31, 2025, and highlighted recent progress across its pipeline of clinical-stage product candidates.
She freed physics, but Emmy Noether couldn’t escape herself
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📊 If Brasileirão ended now: updated table after Sunday’s matches
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As mental health crisis grows, legal skirmish around treatment persists in Orange County
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Scientists revive activity in frozen mouse brains for the first time
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Trump Rejects Deal With Iran on Current Terms as War Rages On
President Donald Trump said Iran is ready to make a deal to end the war but the US wants better terms, signaling no let up in a conflict that’s brought shipping in the strategic Strait of Hormuz to a near standstill and upended energy markets.
2026 Big 12 Tournament scores, results, bracket: No. 1 seed Arizona takes down No. 2 seed Houston for title
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West Virginia repeats, wins program's 21st NCAA rifle title
West Virginia defended its NCAA rifle championship on Saturday, edging out TCU to claim the 21st national rifle title in program history.
Miami’s Community Newspapers hosts Small Business Expo
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Spotify’s newest feature will let you control your recommendations
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Colorado committee recommends rejecting alcohol, marijuana tax hike to fund mental health care
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Power outage stalls business at Mass. State House
A State House electrical outage ended around noon Thursday after the Legislature’s website and internet connectivity within the building were knocked out of commission Wednesday evening. Legislative Information Services sent an email to legislative members and staff on Wednesday around 9 p.m., stating that an electrical outage in the State House caused a service disruption. Portions of the building were running…
ExxonMobil to move its legal home from New Jersey to Texas, citing business friendly environment
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Century Therapeutics Reports Full Year 2025 Financial Results and Business Updates
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This Week in Sports Trivia: March 12, 2026
NFL free agency is always a whirlwind, and this year’s feeding frenzy has been as busy as ever. The legal tampering period — we have a great explainer on that here — ended Wednesday, with a host of deals finally becoming official. Moves included Daniel Jones re-upping with the Indianapolis Colts, Jaelan Phillips signing with the Carolina Panthers and Mike Evans ending a long run with the Tampa Bay Buccaneers in favor of a deal with the San Francisco 49ers. The biggest news of the week, though, was a trade that went down — until it didn’t. That, of course, was the Las Vegas...
Dallas Police Shooting: Armed man killed after barricading himself at Children’s Health hospital
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Sports bar along New Bern Avenue in Raleigh loses permits after multiple shootings
The North Carolina ABC Commission has officially suspended the operating permits for Touchdown Sports Bar in Raleigh following a series of violent incidents over the past year or so.
John Cornyn's filibuster flip: From the Politics Desk
Plus, how Vladimir Putin could be an unintended winner of the Iran war.
‘OPB Politics Now’: Oregon lawmakers head home as 2026 legislative session ends
The short session ended with a flurry of legislation.