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Breaking the Cycle review – meet the charismatic Thai politician striving to change his country’s history
Gripping documentary examines the Future Forward Party’s unprecedented 2019 election result, and its leader’s aim to break Thailand’s repeated military coups
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds
Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
United Airlines Just Issued a Playbook for Any Business Staggered by Skyrocketing Costs
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‘You lose yourself’: inside the mental health crisis hitting gen X women
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VoidStealer malware steals Chrome master key via debugger trick
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American football takes for ever. In which other sports do you spend most of your time not playing the game?
The long-running series in which readers answer other readers’ questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts
It’s time to take politics out of the Small Business Administration
The White House’s politicization of the agency will have a real-world impact on small business owners in the US
It’s time to take politics out of the Small Business Administration
The White House’s politicization of the agency will have a real-world impact on small business owners in the US
‘We can create hype’: H&M’s UK boss on its commitment to the high street
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Jacob Devaney: Man United loanee puts in midfield masterclass
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We are living in a period of political anti-intellectualism. But in pop culture, clever is the new cool
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Trump is eager to disclose details on others’ health – but not his own
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Department of Health retracts claim sunbeds are as dangerous as smoking
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From Project Hail Mary to Saturday Night Live UK: your complete entertainment guide to the week ahead
Scientist Ryan Gosling is alone in deep space – or is he? – and America’s famed topical satire is given a British angle
‘It’s come at the wrong time’: how Iran war has floored the Gulf as a sports hub
Conflict has not only hit sporting calendar but laid bare weakness in plans for diversifying economies through sport
Israel deliberately targeting medical facilities in south Lebanon, say health workers
Medics and officials say there is systematic use of double-tap strikes in campaign to make the south uninhabitable
Walz unveils tech tax in budget; bipartisan support emerges at Capitol
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Chuck Norris, martial arts master and actor, dies at 86
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Reform UK suspends Scottish candidate less than a day after announcing him
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Chuck Norris, martial arts master and actor, dies at 86
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US health department investigates 13 states that require insurance plans to cover abortion
HHS is looking into the states for ‘alleged disregard of, or confusion about’ the federal Weldon amendment
Sports writer and photographer win Quill awards for work for Guardian Australia
Jonathan Horn scooped best sports feature prize for a series on AFL, while Chris Hopkins won for pictures of a cancer sufferer caring for her son
Claimants drop lawsuit against Gerry Adams over IRA bombings
Three people were suing ex-Sinn Féin leader for liability over IRA bombings in UK which left them injured
Sports quiz of the week: youngsters, old timers, records, protests and posh grub
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Marmite maker Unilever in talks to merge food business with US-based McCormick
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Panthers, Flames fight to extend flickering postseason hopes
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Attorney general asks if Kemi Badenoch would object to Jewish public prayer
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How Pauline Hanson’s One Nation is changing politics: Full Story newsroom edition
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New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Kemi Badenoch channels her fantasies as she launches the Tories’ local election campaign
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Double Fine’s Pottery Party Brawler Kiln Arrives April 23 (Plus a Direct Look at the First Public Play Sessions)
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Tiger Woods provides health update as he eyes return at The Masters
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Subnautica 2 publisher’s CEO used ChatGPT in failed bid to avoid paying US$250m bonus to own studio head, court hears
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Volvo Construction Equipment announces closure of Rokbak business
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Cannabis is not an effective treatment for common mental health conditions, says review
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Three-quarters of nine-month-olds in England have ‘daily screen time’
Study showed average time on screens each day was 41 minutes, with some watching more than three hours a day
Key takeaways from Oscars 2026: horror wins, tech loses and politics is hard to ignore
This year saw some Chalamet exhaustion, wins for Warner Bros and memorable music while one winner was nowhere to be seen
Free Palestine and ICE out: how this year’s Oscars got political
As One Battle After Another swept, Paul Thomas Anderson, Javier Bardem and Conan O’Brien gave a welcome reality check to the glitzy ceremony
School IB business management class: European alternatives to Visa and Mastercard ‘urgently’ needed, says banking chief
Operations management
Businesses affected by one of world’s longest Covid lockdowns to receive $125m from Victorian government
Class action settles after retailers argued state government should pay them for economic loss resulting from pandemic lockdown
Sharp rise in young Britons saying ill health is reason they are jobless, study finds
Share of 16- to 24-year-old Neets who report a work-limiting condition up 70% in a decade, says thinktank
Report: The Wolf Among Us Current-Gen Port Is in the Works
New evidence suggests a remaster or port of the original The Wolf Among Us could be in development, as we tie it to a recent report.
‘Cruel hoax’ or ‘work-life balance nirvana’: whatever happened to the four-day work week?
It has been years since the four-day work week was floated as a solution to everything from traffic congestion to burnout. So why aren’t we all doing it now?
One of Britain’s last major chemical plants at risk as energy prices surge
If costs stay high for the next three months, US owner Peter Huntsman says he will close the site on Teesside
Israeli rockets kill 12 healthcare workers in southern Lebanon
The facility was attacked on Friday night, bringing the toll of medical staff to 31 killed in past 12 days
Fetuses likely have more ‘forever chemicals’ in blood than thought
US test of 120 umbilical blood cord samples identified 42 Pfas compounds, which do not naturally break down
‘Everything is going up’: Americans struggle with affordability despite Trump’s claims
US workers are finding it difficult to afford basic necessities as the president claims ‘the economy is roaring back’
New study raises concerns about AI chatbots fueling delusional thinking
First major study on ‘AI psychosis’ suggests chatbots can encourage delusions among vulnerable people
This doctor treated migrants’ severe injuries at the US-Mexico wall: ‘Political decisions made it as violent as possible’
Dr Brian Elmore witnessed a public health crisis unfold at the border near El Paso. He reflects on why it was like a ‘perverse Groundhog Day’
‘We are a completely different political party’: inside the Greens’ membership boom
With membership soaring, the Green party is grappling with logistics, culture shifts and a flood of new activists
NHS and MoD will be urged to buy British tech to drive growth amid Iran crisis
Treasury minister Spencer Livermore trails new strategy as chancellor pins hopes on benefits of AI amid global uncertainty
Confidential health records from UK BioBank project exposed online
Exclusive: Guardian investigation finds data from flagship medical research leaked dozens of times
How to Make a Killing to Wu-Tang Clan: your complete entertainment guide to the week ahead
Glen Powell indulges in some murder most profitable, and the influential rap collective arrive in the UK complete with a clutch of peerless classics
Please drive carefully: scientists plan to transport volatile antimatter for first time
Cern researchers are testing traps capable of moving antimatter, which explodes into energy as soon as it comes into contact with regular matter
Rise of the Bot Masters, Microsoft’s New AI Health Tool and Aaru, the Billion-Dollar Startup Founded by Teens | Future of Everything for March 13
Plus, Microsoft’s new AI health tool and the billion-dollar startup founded by teenagers
British politics is hooked on flashy fake numbers – and the AI investment debacle proves it
A claim that the UK is attracting billions of pounds in AI investment has been debunked. That’s no surprise when our establishment runs on dubious ‘good news’, says Jonathan Portes, a professor at King’s College London and former senior civil servant
The best recent science fiction, fantasy and horror
The Library of Traumatic Memory by Neil Jordan; The Red Winter by Cameron Sullivan; Travel Light by Naomi Mitchison; Between Two Fires by Christopher Buehlman; Spoiled Milk by Avery Curran
Trump policies set to increase rates of lung disease and death, study finds
Experts warn of ‘attack on Americans’ lungs’ from cuts to health programs, environmental rollbacks and other plans
James Blake: Trying Times review – platitudes about politics and Kanye can’t detract from an excellent album
Amid the stylistic shifts of Blake’s seventh record come samples of Dusty Springfield and Dizzee Rascal: gripping distractions from some preachy sentiments
Sports quiz of the week: world records, wrong turns and wild scenes
Have you followed the big stories in football, winter sports, cricket, rugby, horse racing, athletics, basketball and F1?
Everything is a political weapon since Trump’s re-election, says Germany’s ex-economy minister
Robert Habeck says world has moved on from weaponising energy to using tariffs, technology and more to inflict harm
Could the US military turn on Trump?
Jonathan Freedland speaks to Janessa Goldbeck, a former Marine and the chief executive of Vet Voice Foundation, to understand what the people who serve think of their commander-in-chief. If they wanted to, could they disobey his orders?
Tomb Raider I-III Remastered Gets A Switch 2 Release, Free Upgrade "Coming Soon"
New 'Challenge Mode' update launches alongside it
Business of golf betting is booming – and a Tiger Woods Masters showing could cause an explosion
The business of golf is booming, and there is a white whale that could force an explosion.
Why the hell did Starmer pick Mandelson? The latest mug on the media round had no idea
Nick Thomas-Symonds unravelled under barrage of questions – as PM instead bored some mothers and babies in Belfast
Bravely Default Flying Fairy HD Remaster is now available on Xbox Series X|S and PC Steam
Square Enix has announced and released Bravely Default Flying Fairy HD Remaster for more platforms.
Combat Tips for Bravely Default Flying Fairy HD Remaster, Available Now
Japanese RPG classic Bravely Default Flying Fairy HD Remaster is out today for Xbox Series X|S. Master its famous combat system with these starting tips:
Tomb Raider I-II-III Remastered now available for Switch 2, iOS, and Android alongside ‘Challenge Mode’ update
Publisher Aspyr and developer Crystal Dynamics have released a Switch 2, iOS, and Android versions of Tomb Raider I-II-III Remastered alongside a free “Challenge Mode” update for existi…
Entertainment this week: Pride Weekend at Northstar, Magoo and more!
Friday, March 13 RGXC Masters Weekly Friday Training Groups 9-11 a.m. | Royal Gorge Cross Country, Soda Springs. Join us for our Weekly Master’s Groups! On Friday’s we host our Technique Group, focused on develop...