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Democrats 'playing politics' with Americans' safety: GOP lawmaker

Rep. Buddy Carter, R-Ga., criticizes Democrats for 'playing politics' during the government shutdown, impacting TSA agents' pay, on 'Fox Report.'

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Mar 29 • 5:40 PM EDT • Politics • foxnews.com
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Penguins are ‘furious’ over string of disputed NHL decisions

Frustration is building inside the Pittsburgh Penguins organization after a series of disputed NHL decisions against them during a critical stretch. The Penguins are pushing for a playoff spot after a three-season drought. The issue gained attention after comments from…

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Mar 29 • 2:11 PM EDT • Sports • sports.yahoo.com
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Silicon Valley Has Stopped Talking Politics—Except for This Google Executive

AI pioneer Jeff Dean is a rare tech leader who has been publicly criticizing actions by the Trump administration.

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Mar 29 • 12:00 PM EDT • Politics • wsj.com
This hidden state of water could explain why life exists

Scientists have finally found a hidden “critical point” in supercooled water that explains why it behaves so strangely. At this point, two different liquid forms of water merge, triggering powerful fluctuations that affect water even at normal temperatures. The breakthrough was made possible by ultra-fast X-ray lasers that captured water before it froze. This discovery could reshape our understanding of water’s role in nature—and possibly even life itself.

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Mar 29 • 8:00 AM EDT • Science • sciencedaily.com
Researcher invited by McInnis gives talk touting investment in science

As a part of University President Maurie McInnis’ Presidential Lecture Series, Harvey Fineberg, an emeritus professor at Harvard’s public health school, criticized the federal government’s cuts to funding for scientific research.

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Mar 29 • 8:00 AM EDT • Science • yaledailynews.com
Kaiser made $9.3 billion last year. Critics say it has strayed from its charitable mission

Kaiser Permanente, the nation's largest non-profit health group, has veered from its charitable mission and is now scarcely distinguishable from a corporation keenly focused on its bottom line, according to critics.

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Mar 29 • 6:00 AM EDT • Health • latimes.com
His party called him ‘repugnant’ for defying Trump. Brad Raffensperger still thinks he could win GOP nod for Georgia governor

Brad Raffensperger, who resisted President Donald Trump’s 2020 push to “find” votes in Georgia, is running for the Republican nomination for governor. How he does will measure not just the mood of the GOP in a critical swing state but whether candidates who defy the president have a place in Trump’s GOP.

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Mar 29 • 5:00 AM EDT • Politics • cnn.com
Reform insiders fear links to extreme figures such as Andrew Tate will scare off voters

Nigel Farage has called Tate an ‘important voice’ for young men and held back from criticising his misogynistic views

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Mar 29 • 2:00 AM EDT • Politics • theguardian.com
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What teens eat could be affecting their mental health more than we thought

What teens eat might matter more for their mental health than previously thought. A sweeping review of nearly 20 studies found that healthier diets are often linked to fewer depressive symptoms, while poor eating habits may go hand in hand with greater psychological distress. Interestingly, focusing on whole dietary patterns—not just individual nutrients—showed more consistent benefits, suggesting that overall eating habits could play a meaningful role during this critical stage of brain development.

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Mar 28 • 8:00 PM EDT • Science • sciencedaily.com
What teens eat could be affecting their mental health more than we thought

What teens eat might matter more for their mental health than previously thought. A sweeping review of nearly 20 studies found that healthier diets are often linked to fewer depressive symptoms, while poor eating habits may go hand in hand with greater psychological distress. Interestingly, focusing on whole dietary patterns—not just individual nutrients—showed more consistent benefits, suggesting that overall eating habits could play a meaningful role during this critical stage of brain development.

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Mar 28 • 8:00 PM EDT • Health • sciencedaily.com
Badenoch criticised for ‘peddling dangerous fantasy’ about North Sea oil drilling

Conservative leader expected to call for government to lift suspension on licences in drive to reduce energy prices

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Mar 28 • 6:00 PM EDT • Politics • theguardian.com
Jenelle Evans Urges Critics to “Back Off” Amid Son Jace's Mental Health Treatment

Jenelle Evans addressed rumors about her and her family after her son Jace Evans, 16, was checked into a mental health facility following an alleged incident involving his grandmother Barbara Evans.

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Mar 28 • 5:14 PM EDT • Health • eonline.com
😳 Mauritania's players battle over Messi and De Paul's shirts!

The Argentina-Mauritania match has left no one indifferent. Because of the 'Dibu' comments, the criticism of the match, and the image of the Mauritania players.'Dibu' Martínez was very critical of Ar...

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Mar 28 • 2:38 PM EDT • Sports • sports.yahoo.com
Borderlands 4 Faces Backlash Over $30 DLC That You Can Finish in Two Hours

Borderlands 4 DLC faces criticism as players claim the $30 expansion lasts barely two hours, questioning its price and content

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Mar 28 • 10:48 AM EDT • Technology • mp1st.com
‘Marathon’ Is Reviewing Better Than ‘Destiny’ On Metacritic, ‘Destiny 2’ On Steam

Marathon is well-liked by players, which has spurred morale among Bungie devs, no matter what other sales conversations may be happening.

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Mar 28 • 10:07 AM EDT • Technology • forbes.com
Trump’s ICE Crackdown Is Forcing Immigrant Women To ‘Choose Between Their Freedom Or Their Health’

The constant fear and surveillance of immigration enforcement is leading some patients to forgo critical reproductive health care.

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Mar 28 • 9:00 AM EDT • Health • yahoo.com
Kwame Spearman warrants plenty of criticism, not cancellation

All of us are flawed humans, some more so than others. This is the tale of Kwame Spearman who burst onto Denver’s business and political scene a handful of years back. His ride has taken a downhill trajectory. Within the past week, Spearman was shown the door as an undefined executive at the just-opened Denver […]

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Mar 28 • 7:00 AM EDT • Politics • coloradopolitics.com
Health boss exit during Lampard Inquiry 'cowardly', say families

Bereaved families have criticised the timing of Paul Scott's departure during the Lampard Inquiry.

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Mar 28 • 2:32 AM EDT • Health • bbc.com
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Hegseth Criticized for Removing Four Officers From Promotion List

Bitter rifts have opened over the defense secretary’s campaign to reverse policies that he says are prejudiced against white officers.

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Mar 27 • 6:16 PM EDT • Politics • nytimes.com
Treasury plans to put Trump's signature on all new U.S. paper currency in break with tradition

The plans come in tandem with an ongoing effort to get Trump’s face on a coin, which has also drawn criticism since federal law prohibits the depiction of a living president on U.S. currency.

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Mar 27 • 4:00 PM EDT • Politics • pbs.org
Business Lookahead: Gauging the war's impact

STORY: From a worrying drop in stocks to a surge in energy prices from the war in the Middle East to key data on jobs and trade, these are the stories to watch in business and finance in the coming week. ::Look Ahead::War impactThe first quarter is ending with financial markets at the mercy of geopolitics.The Iran war has wiped roughly $7 trillion off global stocks since it erupted.With oil prices up nearly 70% year to date, suddenly interest rates are heading up, rather than down, and energy-hungry AI does not look like such a slam-dunk anymore.Meanwhile, gold has plunged 16% after being nearly unstoppable since the start of 2025.We’ll see whether markets roll on or rollover as the second quarter begins.::Job growth in focusThe U.S. jobs report for March comes out Friday.It will offer a crucial view into the economy's health as investors gauge fallout from the energy price surge.Monthly payrolls are seen rising by 48,000, according to a Reuters poll. February's surprisingly weak report caught Wall Street off guard, showing nonfarm payrolls fell by 92,000 while the unemployment rate increased to 4.4%.Uncertainty over the Iran war is also clouding the economic forecasts for the Federal Reserve, with Wall Street pulling back on expectations for U.S. interest rate cuts this year as the oil price surge fuels concerns about rising inflation.Other U.S. data in the coming week includes retail sales for February and reports on manufacturing and services activity.::Chip checkSouth Korea releases its trade data for March on Wednesday.It will provide an early indicator of how the global economy is holding up in the face of the war and the resulting shock to energy prices. Korea's export-heavy economy is a bellwether for global trade and one of the first to report data from the previous month.Its manufacturing fortunes are of even greater interest than usual, not just because of its dependence on Middle Eastern energy imports, but also because its world-leading DRAM chips are of critical importance to the AI sector and currently in short supply too. ::Inflation assessmentAnd flash euro zone inflation for March is due on Tuesday. After long hovering around the 2% mark, higher energy prices are now expected to push headline inflation up, as they did in 2022. The question is, how large and sustained any jump in inflation might be.Early data is not painting a pretty picture. Private sector growth in the euro zone slowed sharply in March, with input costs rising to their highest in more than three years and supply chains being significantly disrupted.Money markets are now heavily pricing in a rate hike which was almost unthinkable before the Iran war.

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Mar 27 • 3:28 PM EDT • Business • finance.yahoo.com
Hasan Piker Rally Sparks Backlash in Michigan’s Democratic Senate Primary

Dr. Abdul El-Sayed’s primary opponents criticized him for inviting Hasan Piker to campaign with him. Mr. Piker is a fierce critic of Israel.

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Mar 27 • 3:03 PM EDT • Politics • nytimes.com
Understanding protein motion could greatly aid new drug design

For many of us, “protein” is the key element of a food order. However, beyond your preferred choice of meats or plant-based alternatives, proteins encompass a large class of complex biomolecules whose chemical structure is encoded in our genes. Proteins have critical functions in living cells: They help repair and build body tissues, drive metabolic reactions, maintain pH and fluid balance, and keep our immune systems strong.

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Mar 27 • 2:00 PM EDT • Science • news.asu.edu
Seven weeks in, Kristaps Porziņģis enamored with Warriors as free agency looms

Seven weeks in, Warriors center Kristaps Porziņģis is enamored with Golden State ahead of his critical unrestricted NBA free agency.

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Mar 27 • 10:59 AM EDT • Sports • nbcsportsbayarea.com
Apple Now Sending Critical Security Alerts to iPhones Running iOS 17 and Earlier

Apple has begun pushing Lock Screen notifications to iPhones and iPads running older versions of iOS and iPadOS, warning users of active web-based attacks. The alerts, which appear as a "Critical Software" notification from the Settings app, warn that Apple "is aware of attacks targeting out-of-date iOS software, including the version on your iPhone," and urge users to install a critical update to protect their device.

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Mar 27 • 10:21 AM EDT • Technology • macrumors.com
Vanderbilt Lung Transplant Program sets new record

The Vanderbilt Transplant Center is now the second largest lung transplant center in the United States by volume, with 149 lung transplants in 2025, the most ever in one year at Vanderbilt Health. The Vanderbilt Lung Transplant Program leads the nation in organ preservation and regeneration and is among the best in long-term outcomes, demonstrating the success of the interdisciplinary team in caring for these complex patients. Several features make the program unique in the United States, said Konrad Hoetzenecker, MD, PhD, professor of Thoracic Surgery and surgical director of the Vanderbilt Lung Transplant Program. Vanderbilt serves as a “second opinion center” and accepts most complex candidates that are turned down by other centers due to increased perioperative risk. This includes patients over 70 years old, patients requiring combined procedures with their transplant, multiorgan transplantations and sensitized patients (individuals who have pre-formed anti-HLA antibodies who are at higher risk for complications). The expertise and excellent outcomes have attracted patients far beyond the borders of Tennessee; almost half of Vanderbilt Health’s lung transplant recipients come from out of state. “Another unique feature is our minimally invasive transplant program,” Hoetzenecker said. “By using distinct surgical instruments and techniques, the incisions can be kept as small as 7 to 8 centimeters, which results in better healing, less pain and faster recovery. “This minimally invasive approach is embedded in an Enhanced Recovery After Surgery (ERAS) protocol, a multimodal, evidence-based perioperative care pathway designed to reduce surgical stress, minimize complications and speed up recovery. Our unique ERAS protocol, by a dedicated interdisciplinary approach, aims to improve recovery after lung transplant and reduce ICU and hospital stay.” The lung transplant program recently celebrated a milestone — 1,000 lung transplants since the program began in 1990. “This significant achievement reflects the concerted effort of a multidisciplinary collaboration by the Departments of Thoracic Surgery, Medicine, Anesthesiology and Critical Care,” said David Erasmus, MD, associate professor of Medicine and medical director of Vanderbilt Lung Transplant. Lung transplants have been attempted since the 1960s, but they were largely unsuccessful until the 1980s, when surgical techniques were refined and new antirejection drugs proved effective. Patient outcomes steadily improved from the 1990s to the present. Vanderbilt’s fourth lung transplant recipient in 1990, Pam Everett, is the longest-living, single-lung transplant known in the world, recently celebrating 35 years since her transplant. The Vanderbilt Lung Transplant surgical team is led by Hoetzenecker and Caitlin Demarest, MD, PhD, the surgical director and associate surgical director of the Vanderbilt Lung Transplant program. Erasmus is the medical director of Vanderbilt Lung Transplant along with Anil Trindade, MD, associate medical director and associate professor of Medicine.

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Mar 27 • 10:12 AM EDT • Health • news.vumc.org
Spencer Pratt: Newsom is seeing his political ambitions unravel

Los Angeles mayoral candidate Spencer Pratt explains why he is running and criticizes Mayor Karen Bass on ‘Fox News @ Night.’

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Mar 26 • 11:51 PM EDT • Politics • foxnews.com
Researcher invited by McInnis gives talk touting investment in science

As a part of University President Maurie McInnis’ Presidential Lecture Series, Harvey Fineberg, an emeritus professor at Harvard’s public health school, criticized the federal government’s cuts to funding for scientific research.

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Mar 26 • 8:00 PM EDT • Science • yaledailynews.com
Healthcare Priorities in Governors’ 2026 State of the State Addresses

Across the country, Governors from coast to coast made healthcare a centerpiece of their 2026 legislative addresses—identifying common challenges around rural access, workforce shortages, rising costs, and behavioral health, and charting a range of ambitious courses to address them. Rural Access Gaps Rural and remote communities have experienced losses in critical healthcare infrastructure, inherently decreasing […]

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Mar 26 • 2:07 PM EDT • Health • nga.org
Doc Rivers responds to NBPA's critical statement of Bucks sitting Giannis Antetokounmpo: 'He's just not healthy'
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Mar 26 • 12:10 PM EDT • Sports • sports.yahoo.com
Doc Rivers responds to NBPA's critical statement of Bucks sitting Giannis Antetokounmpo: 'He's just not healthy'
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Mar 26 • 12:10 PM EDT • Health • sports.yahoo.com
Opinion: Business resilience requires smart connectivity

Enterprise leaders operate in an increasingly complex digital environment with the scale and sophistication of new threats looming large, making cyber resilience a prerequisite of doing business. | Understanding how connected technologies are evolving and what this means for security, performance and resilience is critical for businesses.

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Mar 26 • 11:00 AM EDT • Business • fiercewireless.com
Good Morning, Nashville! Talking Immigration Data Politics at Vanderbilt University

After a busy day on Capitol Hill yesterday, I landed in Nashville, Tennessee, last night for an exciting two days on campus at Vanderbilt University. Carwil Bjork-James, an anthropologist whose creative use of database construction to support critical scholarship resonates strongly with my own work, generously invited me to give a talk today about the politics of immigration data and to join a Wikipedia edit-a-thon tomorrow on the topic of immigrant detention. I encourage you to check out Carwil’s database project “Ultimate Consequences” about political deaths in Bolivia after 1982, and his book The Sovereign Street: Making Revolution in Urban Bolivia. My talk today is titled “Untangling the Messy Politics of Immigrant Detention Data.” I’ll focus on how immigrant detention data (not just detention centers themselves) become sites of controversy—from the collection and classification choices that shape what we can know, to the strategic withholding and distortion of data for political ends. Drawing on research spanning multiple administrations, I’ll trace how current data controversies in the second Trump administration connect to long-standing tensions in how we measure, interpret, and communicate about immigration. My goal is to move beyond simple partisan narratives and offer a practical guide for anyone working with immigration data to explore both the pitfalls to avoid and the creative opportunities for more transparent, rigorous public communication about immigration realities. If you are on campus, please stop by. Tomorrow I will join Carwil and Vanderbilt students for a Wikipedia Edit-a-Thon to edit and update Wikipedia entries related to immigrant detention with the latest robust information and data. This event is designed to orient participants into how to edit on Wikipedia, provide them with data-driven starter templates on detention facilities, and allow each person to produce an initial article on one element of the network of ICE facilities or one death in custody this year. The workshop is also a demonstration of how to use open data sources to build public knowledge—something I am deeply passionate about. Thank you to Vanderbilt University, the Spatial Histories series, and Carwil for hosting me. I would love to be a part of conversations and workshops related to immigration data on your campus. Students are really eager these days to have informed, critical, and data-driven explorations of our current immigration system. Reach out anytime if you want to discuss the possibility of bringing me to your campus. Subscribe

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Mar 26 • 7:55 AM EDT • Politics • austinkocher.substack.com
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US ramping up production of weapons critical for major war

From Tomahawk missiles to THAAD interceptor seekers, the US is massively increasing its production rates for key munitions amid stockpile concerns.

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Mar 26 • 5:07 AM EDT • Business • businessinsider.com
Intel CEO Lip-Bu Tan: Startup investment is critical for business

Developments in AI, quantum computing and robotics are moving so fast that corporations must stay close to startups to avoid falling behind.

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Mar 26 • 5:05 AM EDT • Business • globalventuring.com
Democrats hope GOP health care cuts will put Alaska, and the Senate, in play

Republican Dan Sullivan lost a bid to stave off Medicaid cuts last year and is now facing a barrage of critical ads.

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Mar 26 • 4:45 AM EDT • Health • politico.com
Central Ohio coffee business fights to keep brewing after farm issue cuts yield

A coffee business rooted in culture and tradition is facing a critical moment.

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Mar 25 • 10:33 PM EDT • Business • abc6onyourside.com
Trump Draws Bipartisan Backlash for Easing Oil Sanctions on Russia and Iran

Republicans and Democrats alike have criticized the Trump administration’s moves, taken to stabilize oil markets rocked by the war with Iran, warning that it is benefiting two U.S. adversaries.

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Mar 25 • 7:00 PM EDT • Politics • nytimes.com
Can Rep. Thomas Massie, Leading Trump Critic, Hang On in Kentucky Primary?

Can any Republican disagree with Trump and get away with it? Thomas Massie’s primary race in Kentucky is a key test.

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Mar 25 • 6:14 PM EDT • Politics • nytimes.com
James Talarico Responds With ‘Love’ To Hegseth Pastor’s Criticism

James Talarico, the Democratic nominee for Senate in Texas, said, “You may pray for my death, Pastor, but I still love you.” The pastor said he was calling for Mr. Talarico’s religious conversion.

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Mar 25 • 5:33 PM EDT • Politics • nytimes.com
High-stakes Senate race in Texas sees proliferation of AI-generated attack ads

Campaigns are beginning to use phony AI-generated images in television ads to sharpen their attacks and, critics say, mislead voters.

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Mar 25 • 5:00 PM EDT • Politics • spectrumlocalnews.com
A Critical Political Season Could Decide if Alaska Is a Failed ‘Petrostate’

A governor who spent two terms cutting services to preserve Alaskans’ oil-funded annual checks is leaving office. Voters must now decide what comes next for the state’s faltering fiscal model.

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Mar 25 • 10:46 AM EDT • Politics • nytimes.com
Critically endangered hare spotted in surprising location for the first time in 40 years — but it was already dead

Scientists in China have announced the first confirmed sighting of the critically endangered Hainan hare in part of its native range in four decades, after spotting its completely flattened carcass on a roadside.

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Mar 25 • 10:38 AM EDT • Science • livescience.com
Service & Solidarity Spotlight: Kaiser Health Care Professionals Ratify New Contracts, Winning Vital Patient Safety Protections

Health care professionals, members of United Nurses Associations of California/Union of Health Care Professionals (UNAC/UHCP, AFSCME), voted to ratify new contracts with Kaiser Permanente, winning critical protections that will directly improve patient care.

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Mar 25 • 10:02 AM EDT • Health • aflcio.org
Abbott legal brief criticizes Paxton’s rushed lawsuit against Harris County’s immigrant legal fund

“Perhaps the Attorney General only recently learned of this program; perhaps the office’s attention was focused elsewhere,” lawyers for Abbott wrote, noting the fund has existed for five years.

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Mar 25 • 9:22 AM EDT • Politics • houstonpublicmedia.org
Nintendo Misses Out On Top 10 In Metacritic's 16th Annual Game Publisher Rankings

A big improvement on 2024, though

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Mar 25 • 9:15 AM EDT • Technology • nintendolife.com
Square Enix was Metacritic’s No. 1 ranked publisher last year, thanks to 9 ‘good’ games

It’s the first time Square Enix has topped Metacritic’s annual publisher rankings…

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Mar 25 • 7:57 AM EDT • Technology • videogameschronicle.com
Democracy Depends on Science—So Scientists Need to Show Up for Democracy

A shared commitment to facts and knowledge, produced independently from political interference, is critical to democracy—and worth fighting to protect.

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Mar 25 • 7:00 AM EDT • Science • blog.ucs.org
Black-Jewish Entertainment Alliance Freedom Seder to Return at Critical Moment

“The goal of the Freedom Seder isn't that everyone agrees, it's more that everyone leaves feeling heard and with a deeper understanding of one another.” – Bianca Tomash

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Mar 25 • 4:15 AM EDT • Entertainment • jewishjournal.com
Crystal Etienne: Florida’s school choice debate isn’t ignoring evidence, it’s asking for it

Critics argue school choice expansion lacks full data and accountability

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Mar 24 • 6:31 PM EDT • Politics • floridapolitics.com
Veteran prosecutor confirmed to lead new Justice Department division targeting fraud nationwide

The Senate has confirmed President Donald Trump’s pick to lead a new Justice Department division focused on prosecuting fraud over critics’ concerns of potential political pressure to target White House opponents

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Mar 24 • 3:47 PM EDT • Politics • washingtonpost.com
Funding Uncertainty Has Consequences

We're asking the U.S. government to release holds on Congressionally-appropriated funding for scientific research, education, and critical activities at the earliest possible time.

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Mar 24 • 2:25 PM EDT • Science • fas.org
Dimon warns on AI job losses, calls for government-business incentives

The potential AI-related disruption of the job market is a critical issue in Washington, with lawmakers trying to curb the amount of job displacement.

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Mar 24 • 2:23 PM EDT • Business • cnbc.com
Marathon has sold 1.2M copies across Steam, PS5, and Xbox

Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]

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Mar 24 • 2:06 PM EDT • Technology • alineaanalytics.substack.com
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Mar 24 • 3:00 AM EDT • Business • customerexperiencedive.com
We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

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Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
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‘Don’t Make Any Deal’: Trump Tells Republicans to Hold Firm on Shutdown Talks

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Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Drew Barrymore says talk show audience member once criticized her dating profile

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Mar 22 • 9:30 AM EDT • Entertainment • ew.com
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms

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Mar 22 • 5:00 AM EDT • Politics • nytimes.com
Beshear Criticizes Vance in Ohio, Stoking 2028 Presidential Tensions

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Mar 21 • 10:21 PM EDT • Politics • nytimes.com
Trump’s Reaction to Mueller’s Death: ‘Good, I’m Glad.’

The president has consistently celebrated the deaths of political foes. His response to Mr. Mueller’s death drew criticism from Republicans and Democrats.

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Mar 21 • 9:41 PM EDT • Politics • nytimes.com
‘They want to colonise us’: Brazil’s Lula warns of foreign interference

The left-wing Brazilian president is critical of US actions throughout Latin America, though he does not name Trump.

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Mar 21 • 7:35 PM EDT • Politics • aljazeera.com
Wrexham’s Hollywood owners’ Sky Sports’ watchalong criticised by Swansea CEO

Sky offered an alternative commentary with Wrexhman owners Ryan Reynolds and Rob Mac alongside regular presenter David Prutton.

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Mar 21 • 12:41 PM EDT • Sports • nytimes.com
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Crimson Desert Dev Promises Patch to Address 'Discomfort Many Players Have Experienced With the Controls,' Apologizes for Awful Keyboard and Mouse Experience

Crimson Desert developer Pearl Abyss has issued a message to players addressing complaints around the game’s controls, which have been widely criticized.

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Mar 21 • 11:30 AM EDT • Technology • ign.com
Microsoft Promises Slew of Windows 11 Changes in Response to "Microslop" Criticisms

With every Windows 11 update seemingly introducing a new bug or somehow breaking some core functionality, it seems as though trust in Microsoft and Windows is at an all-time low, with the recent "Microslop" insult popping up in online tech circles as a sort of culmination of the recent spate of issu...

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Mar 21 • 2:26 AM EDT • Technology • techpowerup.com
Microsoft's 7-point plan to fix Windows 11 makes macOS Tahoe look golden

macOS Tahoe may have its critics, but even Microsoft is struggling to find things to like about Windows 11. The...

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Mar 20 • 3:47 PM EDT • Technology • 9to5mac.com
New study links more immigrants with lower elderly mortality

Researchers say among newcomers are medical, long-term care workers who are arriving amid critical U.S. shortage.

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Mar 20 • 3:15 PM EDT • Health • news.harvard.edu
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Left's political targeting makes a comeback as prominent Democrats advocate for harassment

Fox News contributor Ben Domenech criticizes Democrats including Gov. JB Pritzker and Rep. Maxine Waters over rhetoric targeting Republican and Trump officials on ‘The Faulkner Focus.’

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Mar 20 • 12:43 PM EDT • Politics • foxnews.com
Political tug of war over Iranian women's soccer team prompts criticism in Australia

The United States and Australia’s political tug of war against Iran over the fates of seven members of the Iranian women’s soccer squad who were torn in between appears to have ended

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Mar 20 • 10:17 AM EDT • Politics • washingtonpost.com
Angelo Cataldi’s rant against Philly sports media continues, this time targeting Reuben Frank

Cataldi, who spent 33 years at 94.1 WIP, has spent the better part of a week criticizing the coverage of Philly sports.

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Mar 20 • 7:32 AM EDT • Sports • inquirer.com
Set appropriate state guidelines for critical surveillance technology

I admit it: I’m worried. I’m hearing a lot about surveillance in the public arena. I hear cameras are capturing my car’s license plate wherever I drive, my face as I go in and out of stores and health facilities, and that it’s all used to compile detailed information about me. I read news articles […]

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Mar 20 • 3:00 AM EDT • Politics • coloradopolitics.com
Who Should Be England’s Number 10 at the World Cup?

The 2026 FIFA World Cup is fast approaching, and England manager Thomas Tuchel has some huge decisions to make. Former boss Gareth Southgate came in for major criticism from supporters for continually...

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Mar 20 • 2:15 AM EDT • Sports • sports.yahoo.com
Knights finish critical homestand on down note

Three goals on its first three shots propel Utah to a 4-0 win and a 2-2 homestand for Vegas.

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Mar 20 • 1:32 AM EDT • Sports • sports.yahoo.com
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Political tug of war over Iranian women's soccer team prompts criticism in Australia

MELBOURNE, Australia (AP) — The United States and Australia’s political tug of war against Iran over the fates of seven members of the Iranian women’s soccer squad appears to have ended with the depleted team returning home minus the two players who defected last week.

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Mar 20 • 12:23 AM EDT • Politics • wral.com
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Political tug of war over Iranian women's soccer team prompts criticism in Australia
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Mar 20 • 12:18 AM EDT • Politics • 10tv.com
New dispute emerges around Subnautica 2’s early access release

Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.

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Mar 19 • 5:28 PM EDT • Technology • gamefile.news
Crimson Desert’s Metacritic Score Leads To 30% Pearl Abyss Stock Drop

Crimson Desert's Metacritic score was not what investors wanted to see, leading to a big stock drop, fair or not.

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Mar 19 • 9:53 AM EDT • Technology • forbes.com
'Apparently Not Good Enough for Investors' — Crimson Desert Publisher Stock Price Plunges Nearly 30% Amid 78 Metacritic Score

Pearl Abyss, publisher and developer of Crimson Desert, has seen its stock price plunge nearly 30% in what is seen as a reaction to review scores.

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Mar 19 • 8:05 AM EDT • Technology • ign.com
30 Rochester restaurants cited for critical health violations. See the list

Here's a look at the results of restaurant inspections last month. How did your favorite Rochester place do?

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Mar 19 • 4:08 AM EDT • Health • democratandchronicle.com
Amazon Alexa's UK personality to change with Echo AI update

There has been criticism the Echo has stagnated, while other AI chatbots have become much easier to communicate with.

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Mar 19 • 1:55 AM EDT • Technology • bbc.com
JD Vance deflects gas price concerns with criticism of Biden
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Mar 19 • 12:56 AM EDT • Politics • aljazeera.com
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HHS announces first Rural Health Transformation Program funding opportunity to strengthen rural health care workforce | Health and Human Services North Dakota

North Dakota Health and Human Services (HHS) today announced the first Rural Health Transformation Program funding opportunity is now available to support the retention of health care professionals in North Dakota’s 37 critical access hospitals and their owned and operated clinics. The deadline to apply is 5 p.m. CT April 30.

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Mar 18 • 9:30 PM EDT • Health • hhs.nd.gov
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Prediabetes Detection: A Critical Lever for Health Systems

Dr Aman Chawla explains why prediabetes detection is a strategic lever for health systems aiming to improve quality and lower total cost of care.

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Mar 18 • 8:00 PM EDT • Health • medscape.com
Why people are making fun of Nvidia’s DLSS 5 on social media

Video game fans are responding with criticism and comedy to Nvidia's latest version of its AI technology that boost performance and graphics.

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Mar 18 • 7:02 PM EDT • Technology • apnews.com
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Game Developers "Found Out At the Same Time as the Public" About NVIDIA DLSS 5

Much has been said about NVIDIA's recent DLSS 5 announcement, with many criticisms of the tech stemming from how the neural rendering potentially alters the artistic vision and tone of the game. While NVIDIA insists that developers remain in full control, and that the game studios were involved in c...

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Mar 18 • 5:49 PM EDT • Technology • techpowerup.com
What to know about the Jones Act as the Trump administration unveils a 60-day waiver

Passed in 1920, this law aims to protect the American shipping sector — but it's also faced criticism over the years for slowing the delivery of goods, including critical aid during time of crisis.

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Mar 18 • 3:15 PM EDT • Politics • pbs.org
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Iowa GOP at odds with business groups over health care tax increase

Business groups and taxpayer advocates are criticizing Iowa Republicans for a proposed increase on some health insurance providers.

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Mar 18 • 2:15 PM EDT • Business • desmoinesregister.com
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Thymus may be critical to adult health

Research indicates the often-overlooked organ can be key predictor in longevity, disease risk, and cancer treatment outcomes.

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Mar 18 • 12:00 PM EDT • Health • news.harvard.edu
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