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8 new emojis arrive in Apple iOS 26.4 update for iPhone users
Along with eight new emojis, the latest Apple iPhone and iPad software update includes new Apple Music features such as AI-generated playlists.
Crystal Festival brings sparkle, science, and family fun to Mt. Pleasant
MT. PLEASANT — A weekend filled with discovery, creativity, and hands-on fun is coming to Sanpete County as the Crystal Festival returns this spring with an exciting lineup of activities for all ages. The Crystal Festival — A Rocks, Minerals, Gems, & Crystal Show — will take place April 4–5, 2026, at the Mt Pleasant […]
Organized Money: The Business of Betting on Murder with Sen. Chris Murphy
Bet you can’t guess who is insider trading the Iran War.
Antoine Griezmann to join Orlando City in MLS when Atletico Madrid season ends: Why 35-year-old is still great
Griezmann, a World Cup winner with France in 2018, joins an influx of star players like Lionel Messi and Son Heung-min in MLS
Josh Shapiro endorses James Malone in key Lancaster County Senate race
Gov. Josh Shapiro has officially endorsed James Malone’s bid for reelection in the Lancaster County state Senate district that both parties say could determine party control next year.
UGA student turns mahjong passion into growing business: Marejong
University of Georgia student Mary Dalton Dowdy started her own business, Marejong, teaching mahjong lessons in Athens, Jefferson, Watkinsville and Wrens, Georgia. She found a unique market, becoming one of
High school sports results for Monday, March 23, 2026
MONDAY’S RESULTS Baseball WPIAL CLASS 5A Section 1 Latrobe 13, Penn-Trafford 12 Plum 9, Armstrong 3 WPIAL CLASS 3A Section 3 Deer Lakes 10, Southmoreland...
Grizzlies never threaten Hawks as Memphis falls to Atlanta
The tank was strong for the Grizzlies in Atlanta.1-11 in 12 games. PHEW.
Federal judge sides with Wisconsin in transgender health care suit
A U.S. judge ruled in favor of Wisconsin and 20 other states challenging a Trump administration declaration that tried to limit care for trans youth.
Expanded NICU offers families privacy, innovation
The NICU at Temple Health's new Women and Families Hospital offers twice the space and many more services than its predecessor.
Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds
Antarctica could warm much faster than its surroundings over the next few decades due to a phenomenon known as polar amplification that is well established in the Arctic.
Health in a Handbasket: Chips & Dip
Today we're putting a healthy spin on a snack we all know and love.
Connections: Sports Edition today: Hints and answers for March 23, 2026, puzzle No. 546
Welcome to Connections: Sports Edition Coach — a spot to gather clues and discuss (and share) scores.
Vermont may look across borders to help bring in business
House passes bill to create sister state program for economic development.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Everything you need to know about the ‘Hannah Montana 20th Anniversary Special’ — How to watch, premiere time, who’s coming back and more
Sweet niblets! Hannah Montana is back for an anniversary special. Here's what to know.
Lancaster County public sales: March 22, 2026
Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and
Politics: Iowa Senate majority leader outlines plans for coming weeks
Second funnel week concluded in the Iowa Legislature, meaning that lawmakers’ focus can return to funding, appropriations and other types of specific bills that don’t respond to the Legislature’s self-imposed
Paxton Aaronson scores twice to propel Rapids to 4-1 victory over Sporting KC
Paxton Aaronson scored a goal in each half, Wayne Frederick's first career goal was the go-ahead score and the Colorado Rapids rolled to a 4-1 victory over Sporting Kansas City on Saturday night. Aaronson gave Colorado (3-2-0) the lead in the 12th minute, but Shapi Suleymanov scored for the first time this season — in the 44th — to pull Sporting KC (1-3-1) even. The tie lasted until the second minute of stoppage time when Frederick scored unassisted for a 2-1 lead at halftime.
Apple Has Unveiled 9 New Products This Month
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US House Democrat blasts Commerce's 'highly concerning' $1.6 billion USA Rare Earth deal
A senior House Democrat accused U.S. Commerce Secretary Howard Lutnick on Thursday of structuring Washington's $1.58 billion investment into USA Rare Earth in a way that gives the government "highly concerning" leverage over the company while boosting Lutnick's family-run investment firm.
March Madness Day 1: Duke survives scare as UNC, Wisconsin, AJ Dybantsa go down on Thursday
Who is Nate Burleson? Why has he replaced Ernie Johnson for NCAA Tournament?
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Marmite maker Unilever in talks to merge food business with US-based McCormick
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Firefighters battling flames on roof of building housing row of businesses in Midwood
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Florida GOP’s divisions, cancel culture and Alligator Alcatraz: IFP
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Mobile sports betting dies again in Mississippi Senate
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March Madness 2026 live updates: Where to watch NCAA basketball today, time, channel, what to know
Follow March Madness live as the 2026 NCAA men's basketball tournament kicks off with major matchups and potential upsets across the country.
Cone Health to Cut Ribbon on Two New Mobile Health Units
Two New Mobile Units Launch To Meet The Needs of the Community
Customers help Denver small business owner relocate after 60-day vacate notice
Healthy Returns: Stopping GLP-1s raises risk of heart attack, stroke and death, study says
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From The Sports Desk: Venezuela shows why World Baseball Classic matters
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7 events in Lancaster County this weekend, from a plant shop reopening to Zenkaikon
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Georgia WBB on 'a business trip' in Iowa City for March Madness
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Meet the Mid-Penn Conference winter sports all-stars
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How sports traditions like March Madness can support brain health
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Trump said he wanted one of the Texas Senate candidates to drop out. Now he’s missed the deadline
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House passes 5-year reauthorization to fund small business tech programs
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Quincy, GREDF now accepting RFQs for sports complex project
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Legalized online sports betting faces pushback before key vote
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Women’s Health Research Advancing at UConn
40 research abstracts presented at 3rd annual women’s health-focused research symposium of The Group on Women in Medicine and Science of the UConn School of ...
Scott Borchetta launches Borchetta Entertainment Group management division with Carly Pearce signing
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Iran's Political Prisoners Are in Danger From U.S.-Israeli Strikes
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The Latest: The 2026 Academy Awards get underway
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Trump's war rhetoric is coarse. It's also heard differently, depending on the audience
President Trump and other administration officials have projected confidence and power in Iran in a coarse tone that is unprecedented, according to experts in wartime rhetoric.
What do Maine’s fishermen and restaurateurs have in common? Mental health challenges.
Both our fishing and restaurant sectors shoulder extraordinary strain. If we them to endure here, we must take that into account.
Politics: Iowa nonpartisan group predicts bigger budget shortfall than expected
Iowa will likely operate on a near-$1.3 billion budget deficit over the next fiscal year, according to the latest report from state officials.
Big Ten hockey: Michigan thumps Penn State, advances to final
Michigan defeated Penn State, 5-2, in a Big Ten hockey tournament semifinal at Ann Arbor Saturday night, clinching a spot in the championship game.
Titans agree to restructure Calvin Ridley's contract for 2026
The Tennessee Titans and wide receiver Calvin Ridley have agreed to restructure his contract ahead of the 2026 season.
2026 NFL mock draft: Broncos add massive defensive lineman
The Broncos select a massive defensive lineman in this 2026 NFL mock draft.
Contributor: Federal power grabs on elections are not about fraud
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Evidence mounts suggesting health costs from WV lawmaker moves on data centers, water
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Figuring out why AIs get flummoxed by some games
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HOMETOWN ENTERTAINMENT: “Buddies” opens Friday in downtown Roanoke
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Micah Bob Finds His Foundation in Materials Science
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After firings, funding cuts, and a shooting, can a demoralized CDC workforce recover?
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Lancaster County public sales: March 13, 2026
Witman Auctioneers Inc., of Manheim conducted a public auction of real estate March 5 for the trust of Kathleen March at 644 Symphony Woods Drive, Silver Spring, Maryland. A four-bedroom
Watch HC Bucky McMillan's postgame presser after losing to Oklahoma
Bucky McMillan identified just what went wrong in Texas A&M's SEC tournament opening loss to Oklahoma.
I Watched My Father's Million-Dollar Business Fail — Here's What It Taught Me About Business
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White House Uses ‘Wii Sports’ Imagery In Iran War Video—After Usage Of ‘Pokémon’ Sparked Rebuke
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Silence is not golden when it comes to science and AI
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Birmingham playing for Division III state hoops title after losing early in City playoffs
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Team USA advances at 2026 World Baseball Classic despite shocking loss to Italy
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Why Cowboys, 49ers pulled off trade involving Osa Odighizuwa
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Nonprofit clinics offer crucial lifeline to Georgians living without health insurance
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Beyond The Burn Zone: Maui Wildfires Cause Widespread Mental Health Issues
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Italy GM Ned Colletti gets emotional over 'sports miracle' in WBC
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Iran cannot participate in the FIFA World Cup, sports minister says
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Mobile brain scans sound like science fiction. But they're now helping more Canadian patients
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Ravens cancel Maxx Crosby trade after failed physical: Analysis
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Igor Tudor: Pressure grows as Antonin Kinsky experiment backfires and raises further questions over Spurs head coach
MidEast conflict could hurt Chinese business
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8 new emojis are coming to Apple products with iOS 26.4. Take a look.
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Health Care Heroes honored in Rochester
The event recognized 39 organizations and individuals in the area who have made a difference in local health care.
Can Trump run a war and a midterm campaign at the same time?
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‘Be Amazing’ business-supported fundraiser to be held Thursday
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How Portland's business challenges ripple across Oregon
The city's economic growth depends on restoring livability.
Prep talk: Bell's baseball team is surging with 8-1 record
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Did Ravens Overpay for Maxx Crosby? Veteran Insider Explains
When the Baltimore Ravens reportedly sent two first-round picks to the Las Vegas Raiders for star pass rusher Maxx Crosby, the move immediately stunned the league. Not only was the price steep, but it also broke from Baltimore’s long-standing philosophy.
India face Chinese Taipei in women's Asian Cup: Indian Sports LIVE, March 10
Here are all the updates from Indian sports on March 10, 2026.
Trump administration widens its 2020 election probe as it obtains records from Arizona
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Neil deGrasse Tyson weighs in on aliens, "space jellyfish," movie science and Pluto
7 big political questions about the war with Iran
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How US-Israeli war on Iran is upending global business
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Cartesian Therapeutics Reports Full Year 2025 Financial Results and Provides Business Update
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Bam Adebayo joins Dwyane Wade in Miami Heat history books
Some franchise history for Adebayo.
Winners and losers from the women's Power 4 conference tournaments
Texas coach Vic Schaefer is a winner, with a victory over Dawn Staley and Vanderbilt and Mikayla Blakes own the loser tag.
North Dakota Women's Business Center offers coaching, connections and more
In honor of International Women's Day, The Forum is profiling the organization known for lifting up female business owners.
Things to do in Pensacola: Kites on the Coast; Flora-Bama Beach Run
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Politics: Iowa’s federal lawmakers back Iran war
As the Iran war enters its second week, members of Iowa’s federal delegation continue to back President Donald Trump’s Operation Epic Fury, even as they mourned two Iowans killed in
Severe storms damages Beggs school campus and sports complex
Storm damage at Beggs Public Schools left debris across athletic facilities and caused roof damage at the middle school, though no injuries were reported.
New Business: Caffe Nero to land at Tuscan Village; Dunkin’ gets new spot on S. Willow
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Reality is immaterial in today's politics
Republicans are having a field day over Bill Clinton's testimony that JB Pritzker flew on Jeffrey Epstein's jet. But Democrats are also succumbing to fantasy worlds of their own making.
Legislature passes bill to help Oregonians convicted on 'junk science'
The Oregon Legislature passed a bill creating a legal pathway for those convicted on the basis of discredited \
The Business of Babies’ Gut Health, Planned Parenthood’s Botox Push and What to Know About Multi-Cancer Blood Tests | WSJ Health for March 6
Plus, why Planned Parenthood is making a Botox push and what to know about multi-cancer blood tests
Grammy Winner Estelle, Macro’s Stacey Walker King and More Land on Black Women in Entertainment Honors List
The inaugural event celebrates and recognizes the impact of leadership and cultural influence of Black women in the entertainment industry.