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AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Mark Consuelos injured during “Live With Kelly and Mark ”break as Kelly Ripa recovered from gum surgery
Consuelos revealed a sports-related injury sustained while “Live” was on a between-season break, during which Ripa was recovering from a painful oral procedure.
Florida IAM Members Focus on Political Mobilization at Fall Conference
The IAM's Florida State Council recently held its fall conference, bringing together union leaders and delegates to focus on political education, voter mobilization, and strengthening the voice of working families across the state. Led by President Mike Phillips, the conference emphasized the importance of supporting pro-labor candidates and increasing member participation in the political process.
Scott McTominay has successful heart surgery as return timeframe revealed
Napoli released a statement on Tuesday following McTominay’s heart procedure
Red Wings’ 2027 schedule: Earliest home opener in team’s history
ROCHESTER, N.Y. (WROC) — The Rochester Red Wings have released their 2027 schedule — and they have set the earliest home opener in their history. The team announced on Tuesday that their home opener at ESL Ballpark will be on Friday, March 26. They are set to begin playing against the Syracuse Mets. This start […]
Why Life’s Origin Can Only Be Explained by Design
The reagents of the feedstock are never produced by processes as on the early Earth. Production requires substantial energy and controlled industrial procedures
Immune Cells’ Role as Quality Control Boosts Tissue Health
Macrophages maintain the function of certain organs by eliminating waste products. Studying this process could lead to clues for healthier aging.
Julio Sáenz, the 2026 Rochester Hispanic Business Person of the Year
During "Connections with Evan Dawson" on 9/8/26, Hispanic Business Person of the Year Julio Sáenz. Then, a special rebroadcast of our conversation with the man behind the "Connections" theme song.
New York Yankees vs. Colorado Rockies: series preview
Aaron Judge will return to the lineup against the Rockies, owners of the NL's worst record.
UC develops new Center for Public Health
The University of Cincinnati’s department of public health is in the process of developing a Center for Public Health. The center will centralize public health education at the university and
Section V's Girls Athlete of the Week for Aug. 31-Sept. 6 presented by Turf Masters: Vote now
Your vote will determine who will be the Turf Builders Girls Sports Athlete of the Week for Aug. 31-Sept. 6.
Can what we feed farm animals directly benefit our own health?
Several chronic diseases—obesity, cardiovascular disease, type 2 diabetes and some cancers—have been linked to lifestyles and diets high in calories, based on processed foods and lacking diversity and ...
Many states have legalized marijuana in some form, but under federal law it remains a controlled substance. That conflict creates challenges when cannabis-related businesses seek banking and other financial services from federally regulated institutions. In this video, GAO Director Courtney LaFountain explains: • The federal guidance available to financial institutions serving cannabis-related businesses • Why banks must conduct enhanced due diligence and file additional reports • What financial institutions consider when deciding whether to serve the cannabis industry • Why cannabis businesses may face higher banking fees and limited access to loans • How restrictions on payment processing
Many states have legalized marijuana in some form, but under federal law it remains a controlled substance. That conflict creates challenges when...
6 Impact Training Exercises to Boost Bone Strength, From an Orthopedic Surgeon
In TODAY.com’s Expert Tip of the Day, an orthopedic surgeon describes how this kind of training can help ward off hip fractures.
(BPRW) ProcuraFind® and Ally Financial Announce Strategic Initiative to Advance Small Business Growth Through Education, Readiness, and Opportunity
(Black PR Wire) Charlotte, N.C. — ProcuraFind® and Ally Financial announced a strategic, multi-year agreement focused on helping small businesses build stronger companies through education, financial empowerment, supplie...
A young Tallahassee scientist's Alzheimer's research wins national acclaim
Lily Ma, senior at Tallahassee's Chiles High School, probed the possibility of using stem cells as a vehicle to slow or even halt the degenerative process.
Political strategists outline their plan for Senate control and the algorithm cutting vital Medicaid funding
Plus, the NTSB investigators receive flight recorder data from the aircraft that crashed in Miami.
'Star Trek' 60th anniversary: Why its vision of the future endures
The original 'Star Trek' premiered in 1966, and despite a rocky start, it endures and continues to inspire the franchise's creatives, stars and fans who say its lessons are still relevant today.
Everything to know about Lucas Museum of Narrative Art
The highly anticipated $1-billion building opens Sept. 22. Learn more about its architecture, must-see experiences, rocky start and the questions surrounding "narrative art."
Ebola outbreak outpaces containment despite influx of money and supplies
Although the U.S. has allocated hundreds of millions of dollars and vaccine trials are underway, Ebola deaths continue to climb in the Democratic Republic of the Congo.
Steve Kornacki on a tightening Senate primary in New Hampshire
The open seat is a top target for national Republicans in November, though Democrats are currently favored.
Wycombe sack manager Michael Duff
Wycombe Wanderers have sacked manager Michael Duff just seven games into the 2026/27 season.The Chairboys are currently rock bottom of League One on just three points and are one of three teams withou...
The Market Forces Quietly Adding Thousands to Patient Bills
The true cost of “vertical integration”: patients directed to a higher-priced location for procedures. Or forced to buy from their insurer’s wholly owned pharmacy, which may not stock the drug prescribed or provide it at the lowest price.
Gayle Benson buys another well-known New Orleans skyscraper, adding to growing property holdings
“There is tremendous opportunity in New Orleans, and investment creates confidence, confidence creates opportunity, and opportunity creates jobs and economic growth," Benson said. "We want to be part of that process and continue doing our part."
New Hampshire primaries test Trump and the left
Trump has backed former GOP Sen. John Sununu in the Senate primary, in which Democratic Rep. Chris Pappas is facing off against a democratic socialist.
Personnel note: TECO Peoples Gas powers up SWFL team with Nick Roch
'Peoples Gas made a great hire in Nick Roch.'
China’s Warrior Scientists: Insights from Recent Operations Around Taiwan
China’s marine scientific research ships are expanding their operations around Taiwan, and they are not just there to advance the frontiers of human
Reds want long-term Hughes replacement
With Richard Hughes' move to Al-Hilal now confirmed, Liverpool are seeking a new sporting director for the fifth time since 2022. Hughes joined Liverpool in the summer of 2024 and oversaw the appointments of Arne Slot then Andoni Iraola. Mike Gordon, the president of Fenway Sports Group (FSG), is overseeing the process of finding Hughes' replacement, with Liverpool keen to make a swift appointment.
Ransomware negotiation tactics have turned into a business process
Intel 471's Dave Ross breaks down ransomware negotiation tactics, from victim profiling and test decryptions to multi-extortion pressure.
Chinese tech giants Huawei and Xiaomi launch new foldable smartphones ahead of Apple event
The launches come ahead of Apple’s unveiling of its latest iPhone series on Wednesday, with expectations high that it could also introduce a foldable phone.
The Otherworldly Geology of Vasquez Rocks
Layers of sedimentary rock that jut from the Soledad Basin at surprising angles have long enthralled television and film producers, including the team behind Star Trek.
Trump calls for a Bombardier plane ban, drawing pushback from a GOP senator
The president ripped the Canadian aerospace company Monday amid a trade war with the country, but Sen. Jerry Moran, R-Kan., came to Bombardier’s defense.
Huawei tests ‘logic folding’ chip in handset with higher AI stakes ahead
New smartphone processor is a crucial test of the firm’s attempt to route around lack of access to the best chipmaking technology.
Hamilton West Little League honored with a proclamation. See video
The Hamilton West Little League team was honored with a proclamation for their historic run. The proclamation was presented by Hamilton Mayor Pat Moeller.
Did Marks Save Nets Future With Rockets Trade in 2024?
By reclaiming pivotal draft assets from Houston, Brooklyn secured the building blocks of a new era, pairing Egor Dëmin with Mikel Brown Jr. to anchor a revitalized backcourt.
Ukraine war briefing: New political turmoil in Kyiv as prosecutor general resigns
Anti-corruption agencies raid offices and arrest a deputy of Ruslan Kravchenko in case linked to alleged laundering of phone scam proceeds. What we know on day 1,658
Rockstar May Move GTA 6 PC Launch in Response to Expected Console Shortages
It has long been thought that there would be a long delay between the console and PC launches of Grand Theft Auto VI—GTA V launched to consoles a whole two years ahead of the PC port—however, the unprecedented times facing the PC and console hardware markets may be enough to pressure Rockstar...
AI identifies 800 plant proteins for sustainable food emulsifiers
Scientists at the University of Leeds have developed an AI-driven process capable of rapidly identifying plant proteins with emulsifying properties, potentially replacing synthetic and animal-derived alternatives in food and cosmetic applications.
Does Medication Abortion Cause An Increase In Mental Health Problems?
A new study published in JAMA Psychiatry looked at medication and procedural abortion and the risk of psychotropic medication use. “We examined whether medication or procedural abortion increased risk of mental health medication use,” study author Julia Steinberg told us. Steinberg is Associate Professor in the Department of Family Science School of Public Health at the University of Maryland. "Based on previous research we have conducted, we did not think medication or procedural abortion would increase risk of mental health medication use.”
The war on Iran’s energy infrastructure creates rising political risk
When Israel targeted Tehran’s oil storage facilities in the initial days of the war launched on Feb. 28, black smoke blanketed the capital and plunged parts of the city into darkness. Roughly ten days later, strikes hit natural gas facilities at the giant South Pars field, key oil refineries, major steel plants, and petrochemical complexes, impacting thousands of workers. These attacks on vital energy and industrial assets revealed a critical dimension of the conflict: compounding an already acute domestic energy...
Politicians describe moments they detained man who rushed Amy Acton at Canfield Fair
Just one day after a man rushed Dr. Amy Acton during a campaign stop at the Canfield Fair, she continued campaigning in Cleveland on Labor Day amid the growing
Chivas, growing ever stronger in the Apertura 2026
The Apertura 2026 has represented a growth process for Chivas under Gabriel Milito. After 7 Matchdays, Guadalajara currently sits in second place in Liga MX with 14 points, thanks to a haul of 4 wins,...
Ohio Democrat Amy Acton reflects on a ‘rough day’ as witnesses recall ‘frightening’ confrontation
The Democratic nominee for governor in Ohio was back on the campaign trail Monday, a day after law enforcement officials said an armed man charged toward her at a public event.
Rock music world stunned as beloved musician dies: ‘One of the most remarkable people’
A cause of death has not been reported.
Rock music world stunned as beloved musician dies: ‘One of the most remarkable people’
A cause of death has not been reported.
“Camp Rock 3 ”star Malachi Barton reveals his surprising personal connection to Demi Lovato
“I have a crazy story about Demi,” he tells EW.
‘Camp Rock 3’ star Malachi Barton reveals his surprising personal connection to Demi Lovato
Disney star Malachi Barton — and his mom — had a ‘special moment’ with Demi Lovato on the set of ‘Camp Rock 3.’
You won't believe this crazy Amen Thompson stat
Houston Rockets forward Amen Thompson finished second in dunks during the 2025-26 season, helping propel him to a career-high in points per game.
Endoscopic Nipple-Sparing Mastectomy Now Available at Boulder Community Health
Susan Hagen, MD, FACS of BCH’s Boulder Valley Surgical Associates (BVSA) recently performed the first E-NSM procedures in Colorado.
Is GTA 6 Too Realistic for Its Own Good? Refueling Cars and Gun Restrictions Spark Debate
Early Grand Theft Auto 6 details have sparked debate about whether Rockstar Games' latest is too realistic for its own good.
New Mexico Democrats push back over Trump posts about renaming the state ‘New America’
The president posted repeatedly on social media over the weekend, and New Mexico Democrats leaped to respond to the ones about their state.
Two years after its rocky launch, Civilization 7's first paid expansion Earthrise is on its way - but first comes the atomic age
As the legendary Civilization series celebrates its 35th anniversary, developer Firaxis has unveiled a host of new updates coming to Civilization 7.
Ready for winter? TGR kicks off ski season in Park City
Actually, It Is Rocket Science brings big lines, deep snow and Teton Gravity Research’s 31st annual ski film to the Jim Santy Auditorium on Sept. 23.
24 Mind-Blowing Science Facts You Won't Forget
I'm gonna need a good business day or two to process these.
Weirdly Fascinating Science Facts That Will 100% Break Your Brain
I'm gonna need a good business day or two to process these.
Weirdly Fascinating Science Facts That Will 100% Break Your Brain
I'm gonna need a good business day or two to process these.
Scientists Captured Trillionth-of-a-Second Snapshots of a Chemical Reaction Essential to Life
Learn how scientists are able to capture “snapshots” of extremely rapid processes, called proton-coupled electron transfer (PCET) reactions.
Rochester man shot inside Lake Avenue business
A 29-year-old Rochester man was shot at Porto Roc Soxial Lounge, formerly Taste of the Bahamas, police said.
New TV shows to watch this week: Tune in to 'R.J. Decker' on ABC, stream 'The Paper' on Peacock and revisit 'Crazy Ex-Girlfriend' on Pluto TV
Fall TV season is getting underway — starting with Scott Speedman's P.I. procedural, Netflix's "Crew Girl" and Season 2 of "The Paper."
Commission to present long-awaited Innovation Act proposal
The European Commission will present its proposal for an EU Innovation Act on September 9, with a focus on strengthening public procurement as a driver of innovation and facilitating the use of intellectual property (IP) to secure financing.The proposal was initially meant to be published in March. No explanation has been given for the delay, but it may be linked to issues with the associated impact assessment.The Commission’s Regulatory Scrutiny Board issued a negative opinion on the draft impact assessment following its meeting on January 28, and again on February 27, according to a draft of the Innovation Act published by Agence Europe.In it, the Commission lays out the steps it has taken to address the board’s concerns, including avoiding overlap with the upcoming revision of the EU Public Procurement Directives and removing a mandatory target for EU member states to increase overall innovation procurement spending.The Innovation Act, which was included in last year’s start-up and scale-up strategy, is meant to reduce barriers to bringing innovative solutions to the market and speed up the path from research to commercialisation.Central to the initiative, according to the draft proposal, is the introduction of a harmonised EU framework for the procurement of R&D services by public buyers, including pre-commercial procurement. The plans would also introduce an EU preference in public R&D procurement.“Other leading economies in the world are investing five to eight times more in public procurement of R&D than the EU,” it notes. In Europe, the lack of harmonised rules has led to divergent practices across the bloc, legal uncertainty and limited use of joint, cross-border R&D procurement, it says.Related articlesCommission postpones European Innovation ActParliament draft report adds EU Inc safeguards to prevent fraud and regime shoppingThe text highlights a lack of clarity around the valuation and monetisation of IP as another barrier to the commercialisation of research results. Currently in the EU, IP is rarely used as collateral in financing, which restricts the growth potential of innovative firms. A key reason for this, according to the Commission, is the absence of a harmonised methodology for valuing IP.To address this issue, it plans to introduce an EU-wide IP valuation framework, a digital marketplace for commercialising IP, and a competence centre to help innovators access IP-backed finance.The issue was highlighted by a recent report by the European Union Intellectual Property Office, which referred to developing a “functional market for IP-backed finance” as a “core competitiveness imperative for the next decade,” and key to ensuring capital unlocked by other EU initiatives reaches innovative firms.The Innovation Act is one of several ways the Commission hopes to reduce fragmentation in the single market and help innovative companies to scale in Europe, complementing other initiatives such as the EU-wide corporate regime, dubbed EU Inc.The leaked draft is not the final version that will be published on September 9, according to a Commission official.
PKK warns disarmament process at risk unless Turkey links surrender to political reforms
Bayik said the National Solidarity and Social Integration Law does not clearly connect the surrender of weapons with a transition to democratic politics.
Most kids don’t know their rights. New book aims to fix that
Iowa City native and former public defender Emily Galvin Almanza has written “Andromeda Diaz and the Reasonable Doubt,” a middle-grade mystery to teach kids their constitutional rights and the power of due process.
Why Alexandria Ocasio-Cortez’s egg freezing is one of 2026’s most interesting political moves
The Democrat documented her clinical process for postponing motherhood and, in doing so, widened the institutions’ reproductive-health framework while also offering clues about her possible future plans
Physitrack Wins Deal with Large US Healthcare System Following Competitive Process
Three-year enterprise agreement with a total contract value of approximately US$390,000 (approximately EUR 336,000) in total, subject to signing of the software services agreement.New York City, September 7, 2026Physitrack PLC (Nasdaq First North Premier Growth Market: PTRK), a global provider of d…
Amending Virginia: Virginians may change the voter rights restoration process for felons
Watch the fourth episode of our limited series on constitutional amendments now.
Hakim Ziyech set to join Botafogo
Former Chelsea forward Hakim Ziyech is set to move to Brazilian football after cancelling his contract with Wydad AC.The Moroccan has played in three different countries since leaving Chelsea, playing...
Leeds gather momentum as Gudmundsson returns to starting XI
It has been a long wait for Leeds fans to see Gabriel Gudmundsson back in action in a competitive match for the Whites. "The process starts now, and it is going to get better and better for us," said Gudmundsson.
Scientists reconstructed a Wyoming forest from 56-million-year-old fossil leaves; it lost about 60% of its canopy during ancient warming and took more than 100,000 years to recover
Deep in the rock record of Wyoming, a layer of fossil leaves tells a quiet but powerful story about what happens to forests when the planet warms rapidly. About 56 million years ago, during a spike in global temperatures known as the Paleocene Eocene Thermal Maximum (PETM), a lush subtropical forest that once covered the region lost roughly 60 percent of its canopy.
Politics in NI: What are the possibilities for Stormont reform?
A growing question among local politicians concerns whether Stormont should be reformed. If rules or procedures are changed, can that make local politics more effective? Will it better serve the people who live here? Over the course of 2026 these conversations have grown louder and more frequent. It is one of the central topics of...
Western Michigan President Admits He’s “Not in Love With the Process That Was Applied” After Big Ten’s Explanation for Michigan Win
The Western Michigan Broncos suffered a last-minute defeat against the Michigan Wolverines in what could’ve been one of the biggest upsets of Week 1. The Broncos were in the lead until there was one second left in the game, when officials turned back the clock and gave the Wolverines a final throw.
UN envoy urges progress toward inclusive political process in Sudan
Pekka Haavisto discusses de-escalation, civilian protection and prisoner exchanges with army chief Abdel Fattah al-Burhan | Anadolu
This Week On FloRugby: Sep 7
See what's streaming on FloRugby from Sept. 7-13, including Racing 92 vs. Lyon, Toulon vs. La Rochelle and Toulouse vs. Bordeaux-Begles.
3 Steps to Support Mental Health for Rural Youth
(Feature Impact) Young people face a growing number of pressures, including academic expectations, social responsibilities, complex family situations and uncertainty about their own futures. Mental health support is important for all – but in many rural areas, those pressures are even greater.According to the Centers for Disease Control and Prevention, the suicide rate for rural youth ages 15-19 is 74% higher than their urban counterparts. Barriers like limited insurance coverage, unreliable internet for telehealth, scarce providers, long drive times and lack of public transportation make it harder to get mental healthcare when it’s needed. Plus, asking for help can feel like opening oneself up to judgment and stigmatization.That’s why Rural Minds, the only nonprofit focused on mental health for rural communities, created the Rural Youth Mental Wellness pilot program supported by Boehringer Ingelheim. It was developed by an advisory committee made up of rural youth to provide their peers with practical, free, accessible mental health resources. Incorporating feedback on the pilot, the updated program sponsored by the Sompo Foundation is now launching its national rollout.“A young person’s ZIP code should never determine whether they can access meaningful mental health support where and when they need it,” said Jessica L. Schleider, Ph.D., director, Lab for Scalable Mental Health, Northwestern University. “Our lab is thrilled to partner with Rural Minds as they champion evidence-based, anonymous, freely available support tools designed to overcome barriers to help-seeking faced by rural youth across the country.”If the rural mental health crisis affects you or a loved one, consider these ways to help.Break the Stigma Surrounding Mental HealthIn communities where self-reliance is valued, asking for help can sometimes be viewed as a sign of weakness. Young people who feel unheard and unsupported often struggle with being vulnerable, so they continue carrying their increasingly heavy burdens alone.Parents, educators, healthcare providers, community leaders and peers can work to change that culture by normalizing mental health conversations. This includes helping teenagers feel seen and accepted by educating them on mental health issues and coping strategies, listening to their experiences without judgment, sharing your own stories and reminding them it’s courageous to seek support.Consider Single-Session InterventionsThe first step is always the hardest when it comes to seeking mental health support, and not every struggling young person is ready or able to see a therapist. With access to free, confidential, self-guided materials to begin building mental wellness skills, the first step may be less scary.Single-Session Interventions (SSIs) are brief, structured online courses designed to teach youth practical skills for handling stress, low mood, self-image and more. The Rural Youth Mental Wellness Program offers SSIs in partnership with Project YES (Youth Empowerment and Support), a free digital resource developed with Northwestern University’s Lab for Scalable Mental Health at the Feinberg School of Medicine.Anonymous access to SSIs through the partnership provides strategies for:Improving moodRethinking body imageReframing negative thoughtsKnowing your power to changeTaking steps toward goalsProtecting LGBTQ+ prideHandling self-harm urgesStaying safe amid dark thoughtsEach SSI typically takes 5-10 minutes. Although SSIs are not a replacement for therapy, they provide a research-backed source of support for young people experiencing bouts of stress or low-to-moderate distress.Know When to Seek Professional HelpSelf-guided resources and supportive conversations are a valuable starting point, but sometimes young people need qualified professional help. Look for symptoms like worsening mood or behavior, substance use, self-harm or difficulty managing everyday tasks, and take teens seriously when they express dark feelings.Doctors and counselors can provide personalized support for youth in crisis, and the 988 Suicide and Crisis Lifeline offers free, confidential 24/7 support for mental health by dialing 9-8-8.“I grew up in a small town where mental health was almost taboo,” said committee member Asheton Medlin. “Being part of the committee that built this program let me help make sure rural youth today have the support I didn’t. I’m excited to help bring these resources to them because this generation deserves the chance to grow up and change the world.”Find more information at RuralMinds.org.Photos courtesy of Shutterstock
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.#placement_976606_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid976606 = window.pid976606 || rnd;var plc976606 = window.plc976606 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=976606;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid976606+';place='+(plc976606++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126610_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126610 = window.pid1126610 || rnd;var plc1126610 = window.plc1126610 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126610;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126610+';place='+(plc1126610++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help.Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
8 Daily Habits to Support Your Heart, Kidney and Metabolic Health
(Feature Impact) When it comes to protecting your heart, supporting your kidney function and improving your metabolic health, you’ll find the advice for each one looks similar. That’s because your body’s systems are deeply interconnected: what affects one will have ripple effects across the others.#placement_1126603_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid1126603 = window.pid1126603 || rnd;var plc1126603 = window.plc1126603 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=1126603;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid1126603+';place='+(plc1126603++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');Cardiovascular-kidney-metabolic health, or CKM health, is a perfect example. When any one of these systems is compromised, it can lead to problems with the others. Therefore, it’s not uncommon for health problems like heart disease, stroke, diabetes and kidney disease to develop or worsen simultaneously – a condition collectively known as CKM syndrome.The reverse is also true, so habits that are healthy for your heart will have a positive effect on your kidneys and metabolic system and vice versa. Consider these simple strategies that align with the American Heart Association’s Life’s Essential 8, a list of healthy steps that can improve overall health. Learn more about how these habits and health measures affect your CKM health at Heart.org.Choose Healthy Foods – Food is your body’s fuel, so fill your tank wisely. Certain types of foods can help your blood pressure, cholesterol, blood glucose and triglycerides stay within healthy ranges, while poor nutrition can push those numbers into more dangerous territory. Focus on vegetables, fruits, whole grains, plant-based proteins (e.g. beans, legumes and nuts) and lean animal proteins (e.g. seafood, skinless poultry and low-fat dairy). Drink plenty of water throughout the day and limit added sugar and salty or fatty foods.Stay Physically Active – Exercise doesn’t have to feel like a chore – in fact, some of your favorite hobbies may already count. The American Heart Association recommends aiming for 150 minutes per week of moderate physical activity like dancing, gardening or walking, moving quickly enough to elevate your heart rate and break a light sweat. Alternatively, choose 75 weekly minutes of vigorous exercise that gets you breathing hard and fast; think running, swimming, playing tennis or riding your bike on hilly terrain.Avoid Nicotine – Tobacco and other nicotine products can raise your blood pressure, damage blood vessels and increase your risk of heart attack and stroke, which are all bad news for your CKM health. If you’re currently trying to quit, you aren’t alone, so don’t be afraid to seek out support groups and resources to help. Prioritize Healthy Sleep – Sleep gives your body a chance to rest and recover from the day, but it’s often one of the first things people sacrifice when life gets busy. Poor sleep can increase your risk for heart disease, weight gain and other issues. Aim for a solid 7-9 hours a night. Keep your bedroom cool, dark and comfortable, and do your best to limit distractions like late-night smartphone scrolling.Watch Your Blood Pressure – When your blood pressure is high, it forces your heart to work harder to pump blood through the body, which can weaken it over time. It can also damage the delicate arteries in and around the kidneys, putting CKM health further at risk. Information is power, so check your blood pressure frequently to know whether further action is needed to keep it under control.Manage Your Blood Sugar – High blood sugar can damage the kidneys, eyes, blood vessels and more, thereby increasing your chance of developing harmful CKM conditions. Controlling blood sugar is particularly important for people with diabetes. If you don’t have diabetes and still experience frequent blood sugar spikes and crashes, talk to your doctor.Control Your Cholesterol – Cholesterol comes in both “bad” (LDL) and “good” (HDL) forms, requiring a balancing act to keep your levels within a healthy range. If LDL is high and HDL is low, your risk of clogged blood vessels, heart attack and stroke are higher. Healthy levels keep blood flowing to your heart and kidneys, supporting your metabolic health in the process. See your doctor for regular bloodwork so you can monitor cholesterol changes.Maintain a Healthy Weight – Since excess body weight puts pressure on the heart, kidneys and other organs, a healthy body weight helps lower your risk of CKM syndrome. Whether you’re hoping to maintain or reduce your weight, regular exercise, healthy eating and quality sleep are all great ways to achieve your goals.
SEERS’ AI-powered wearable ECG monitor wins Health Canada approval
SEERS, a wearable AI diagnostic monitoring company, said Monday that its AI-powered wearable electrocardiogram analysis solution mobiCARE has received a Class II Medical Device Licence (MDL) from Health Canada.Health Canada granted the licence last Thursday (local time), following an application sub
How Mental Health Influences Bladder Function and Lower Urinary Tract Symptoms
Lower urinary tract symptoms are closely associated with anxiety, depression, chronic stress, and broader psychosocial burden, with evidence suggesting complex interactions between psychological state, sensory processing, stress pathways, and bladder function. Although some relationships may be bidirectional, current evidence does not establish a universal causal pathway, reinforcing the importance of integrated assessment and management.
Wisconsin vs Notre Dame football highlights at Lambeau Field
Wisconsin and Notre Dame are playing in the Shamrock Series at Lambeau Field to begin the college football season. Check out photos from the action.
Scientists recreated an ancient Chinese bronze-casting technique with 3D printing; a process that took weeks now takes under 40 hours
Researchers have recreated the logic of an ancient Chinese bronze-casting technique with digital modelling, 3D printing and substitute materials, cutting a process that traditionally takes weeks to less than 40 hours. The study focused on ‘piece-mold casting,’ a distinctive method used to produce ritual bronzes during China’s Shang and Zhou dynasties.
Nicolas Cage Reacts To ‘Spider-Noir’ Cancellation After “Perfect” One-Season Run
EXCLUSIVE: Spider-Noir star Nicolas Cage is speaking out about Prime Video’s decision not to proceed with a second season of the superhero series. “For me, one season is perfect, having said what I wa...
92% of Health Providers Want Patients to Prepay
Americans are being asked to pay for costly medical procedures up front. Roughly 92% of U.S. health providers this year are either encouraging prepayment,
Yankees Announce Aaron Judge News Before Padres Game
Aaron Judge remains on track to return during the New York Yankees‘ upcoming homestand. The captain has missed more than three months with a stress fracture in his first right rib. Manager Aaron Boone said Judge could return during that homestand, which runs Sept. 8-13 against the Colorado Rockies and New York Mets. The update […] The post Yankees Announce Aaron Judge News Before Padres Game appeared first on HEAVY.
The core anti-Pangram constituency is phony writers
Welcome to The Closing Argument, our verdict on the news, plus everything The Argument published and appeared in this week. The Verdict, by Kelsey Piper A lot of people hate AI for drowning the internet in slop and displacing human creatives. You might think that these people would be thrilled by a program that can identify and flag AI-generated work. But many people who hate AI also hate Pangram, an impressively accurate AI detector that produces very few false positives, according to high-quality independent research. This loathing found its most recent expression in a bizarre Wired article that amplifies a wide range of false arguments from Pangram skeptics: that AI detectors are racist (they’re not) or ableist (they’re not)1 or don’t work (this one does)2. Rather than starting from the premise that it would be really valuable to have a working AI detector and scrutinizing Pangram to make sure it lives up to that promise, the article starts from the premise that Pangram obviously has bad vibes and sets out to discover why. (One answer: The CEO microwaved lunch during an interview!) Why aren’t writers who resent Pangram more eager to distinguish themselves from posters who are having ChatGPT ghostwrite all their work? There are a few different things at play, but I think one key dynamic is this: These are often the same people. A core constituency for arguments like Wired’s is “writers” who are using AI to write their posts but resent this fact being made public. They stand to lose from AI detectors because AI detectors call them out. Share When Substack announced a partnership with Pangram, a sizable fraction of the platform’s authors rose up in outrage. Some people had experience with other AI detectors that didn’t work, and some felt that AI writing ought to be encouraged — both of which are fair enough. But the fury was fueled by authors passionately insisting that Pangram kept wrongly accusing them on almost every post they published. Pangram can be wrong, especially on short passages. But in the overwhelming majority of cases where Pangram looked at a whole blog post rather than a single paragraph, the program correctly detected work as AI. Even if we can’t be 100% sure in any individual case, we can notice the trend in the aggregate. Wired quotes Sam Illingworth, a professor of critical AI literacy at Edinburgh Napier University, who said, “I don’t think [AI detectors] work. … I think that detectors are prejudiced against certain people.” This spring, he said that he used AI for research and editing; this summer he acknowledged that in addition to research and editing, he also uses it “now and then for a turn of phrase I keep.” Pangram informs us that most of his posts are 100% AI-written (some are mixed AI-and-human) and that 100% AI-written posts started appearing last year. The favorable interpretation is that, as someone whose recent work Pangram consistently mistakes for AI, Illingworth sees Pangram’s flaws firsthand. The unfavorable interpretation is that the tool’s credibility trades off against his own, because its account of who writes his posts is not consistent with his. Illingworth is not alone in insisting the detector does not work. “It’s a Monday night in late July, and I’m pasting my own Substack draft into an AI detector for the first time. Not because I’m worried. Because I’m curious. I wrote every word of it myself, the way I write everything, out loud in my head first, in a rhythm that still carries the accent of a language I learned to think in before I learned to write in this one,” begins one Substack post by an author indignant that Pangram flags her writing as AI. “That’s the part I had to sit with before I could write this.” If you, like me, have worked with AIs a lot, you won’t even need Pangram there. The author of that piece is AI. It is obviously AI! I checked 10 other posts on the blog, and they were also obviously AI! “I have spent 22 years as an award-winning author and essayist. And now this bullshit tool that learned from MY writing is going to accuse me of plagiarism,” popular Substack writer Carlyn Beccia wrote in an anti-Pangram post. “For the last and final time, AI DETECTORS DO NOT WORK.” Here’s what her writing sounded like in 2020: “Most success stories revolve around one person who believed enough in you to say — give it a try. We call these people muses, but they are so much more than that. They are the strong man giants whose shoulders we stand on so we can see the horizon. Throughout the editing process, I am sure my editor felt less like a giant of greatness and more like Atlas with the world on her shoulders.” Pangram says it was 100% human-written. (So were other articles of hers in 2020.) And here’s what it sounds like now: “And then there is the reshuffling, which sounds like paperwork until you remember that empires have always loved paperwork. The Trump regime recently moved special education oversight from the Education Department to HHS. That is not a minor bureaucratic transfer. It changes the frame.”3 Pangram says this is mostly AI. I am not convinced that Pangram is wrong. In my own experience, Pangram is very effective on long texts — if it marks a long essay as AI, the essay was either written by AI or deliberately written to sound like AI. On tweet-length or paragraph-length texts, it’s not perfectly reliable. It seems to work just as well for non-native English speakers as for native speakers. While I have seen dozens of claims of pre-2022 text returning a positive result on Pangram, I have tried repeatedly to corroborate those and have never once succeeded. To be clear, I’m absolutely not saying that complaining about Pangram suggests a writer is a cheat. There are plenty of other concerns. Most are mistakenly premised, such as the false claim that Pangram trains on work you put into it, but others are reasonable: It’s unreliable on sufficiently short text segments; it creates an internet witch-hunt mentality when there are defensible uses of AI; people who are open about their AI use are sometimes blamed, when the only people really doing something wrong are the ones who hide it; and it isn’t perfect, so a single positive result shouldn’t be taken as decisive proof of misconduct. I’m happy to concede that Pangram is imperfect and possible to over-rely on. If an author’s posts are mostly non-AI and one scans as partially AI, this could be a mistake. It’s also possible to defeat Pangram with intentional effort. If you think we need something more robust and more reliable, fine! But if you don’t like AI and don’t like Pangram, your attitude really ought to be that it’s a shame that our existing tools for AI detection are imperfect, and it’s important to invent better ones. If your stance is instead that AI is evil and so is looking for AI, then ultimately you’re contributing to the sloppification of the internet. You’re making it harder for people who write their own text to distinguish themselves, and providing cover for authors who are definitely not writing their own text. Subscribe Top stories this week, by Kobe Yank-Jacobs Commentators often worry that the decline of reading could mean the decline of liberal democracy — but deliberative governance actually predated widespread literacy. This week, Maibritt Henkel pointed out that many liberal cultures thrive on a culture of raucous, interactive debate, which can happen in-person as easily, if not more so, than in text. Read on, dear reader, to learn more. It may actually cheer you up: [ ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) [ Reading won’t save liberalism ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) Maibritt Henkel · Sep 1 [ Read full story ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) It used to be bad to downplay climate change (if we mean denying its reality). Today, it’s actually good to downplay climate change (if we mean keeping the issue out of political fights so we can make real progress). This counterintuitive view is called “climate hushing,” and contributor Alex Trembath argued that it’s the key to enacting good policy going forward. Get up to speed on the latest in climate politics: [ ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) [ We won’t stop climate change by talking about it ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) Alex Trembath · Sep 2 [ Read full story ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) Canada’s Prime Minister Mark Carney is standing up for the forces of liberalism against Donald Trump’s assault on our closest ally. So, why is one prominent left-wing commenter attacking Carney? Columnist Matthew Yglesias explains: [ ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) [ When "economic liberty" means central planning ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) Matthew Yglesias · Aug 31 [ Read full story ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) 🌟Abundance Wins of the Week🌟 Shout out to my home state of California, whose legislature passed two housing bills this week. One requires a housing density minimum in transit-oriented areas of the state’s most transit-rich cities (Los Angeles, Sacramento, San Francisco, Oakland, San Jose, San Diego, and Long Beach). Another bill closes two common loopholes used by third parties to delay housing projects, including an opportunity to challenge maps of a given lot created by the developer after a project has been approved. Shout out to our big-state rival, Texas, where pro-housing SB 785 took effect this week. The new state law requires municipalities to have at least one district permitted for manufactured housing without a special permit. This will promote zoning changes in 44% of municipalities. The company Fervo Energy signed a deal with Google for what is set to be the world’s largest enhanced geothermal facility, proving a technology can work at a scale that could be crucial to a decarbonized, energy-abundant economy. Share Worth watching… This week, forecasting legend Nate Silver joined Jerusalem, Matt, and Jeremiah on a crowded episode of the pod. It was a party. And speaking of parties, our round table debated the factional lines within the Democratic Party: Is it possible to be center-left and also anti-establishment? Watch or listen to find out: The Rio Grande Valley in Texas is one of the areas that swung hardest toward Trump in 2024, but musician Bobby Pulido is running to flip it back. Right now, The Argument/Split Ticket’s model has him running 1.1 points behind his Republican opponent in a district Trump won by 18 points. Tune in to find out how he differs from national Democrats and what he thinks he can to do win this seat. On Thursday, Bernie Sanders was among the first politicians to call for a ban on superintelligence. My guest this week, Andrea Miotti, has been lobbying to ban superintelligence for several years, most recently in the U.K., U.S., and Canada. I asked him how he gets legislators to take speculative risks seriously, and we dug into what plans might look like to actually pass a ban. Listen to learn more: What’s News with The Argument The Argument recommends, by Kobe Yank-Jacobs If we ever lose track of Justin Zuckerman, I’ll have the team split up and check all the movie theaters in the city. I’m shocked (and a little jealous) at how often he gets out to see good cinema. This week, he brings us It Ends, a “horror-ish movie,” which he described as a “Gen Z Waiting for Godot.” I was intrigued before he added that it was “funny, dark and existential” — at which point I was fully locked in. I guess I also had existential themes on the mind this week. One morning, a single line from a poem I read long ago just came to me: “Is death a stretch of time in which a life is just a flash?” The poem is called “From 20,000 Feet” by Heather McHugh. I suggest the version in The Vintage Book of Contemporary American Poetry, which, by tradition, my best friend and I always bring backpacking, extra weight be damned. We’ll stay thematically dark for just one more rec from senior editor John Robert Thomason, whose upcoming trip to Baltimore reminded him to suggest Michael Clune’s memoir White Out (about being addicted to heroin in Baltimore in the 1990s). Ben Lerner’s blurb called it _“_Disturbing, brilliant, hilarious—it’s as if Proust had written Jesus’ Son.” John told me this “seems accurate, with the caveat that I’ve never read Proust.” I, personally, have also shelved Proust until retirement. At this point, I was a little concerned for the team since all of us tossed out such psychologically grim material — maybe we’re all down about the end of summer — but thankfully, at least a few of us were into more upbeat selections. Milan Singh recommended Made In’s 5-quart stainless clad saucier, suggesting he had some fun in the kitchen. Jeremiah Johnson asked if he could recommend yet more Carly Rae Jepsen. Once denied, he offered up Game Changer instead_,_ calling it “the most wildly creative game show, maybe in the entire history of the genre.” Eli Richman mentioned _Lucky, “_a B-tier show with an A-tier cast and an S-tier theme song.” I suppose he was recommending the song, Horns of a Bull. Still, despite these cheerier recs, I couldn’t help but be concerned that we were subconsciously worried about racing toward summer’s end — the end of swim trunks and splashing around. Then a message landed reminding me of the three-day weekend to come. A whole extra day for sunshine. One more swim in the lake. I was grateful this called to mind yet another line from a poem, one by Mary Oliver, the patron saint of every gorgeous summer day (and about whom a documentary is now out). Speaking to God in the poem “Thirst,” she wrote: grant me, in your mercy,a little more time. Love for the earthand love for you are having such a longconversation in my heart. We have merch! We have quarter-zips, keychains, hats, and stickers. Each one is a great conversation starter in its own way. Buy them here. Subscribe More to read: [ The Opening Argument ](https://www.theargumentmag.com/p/seeing-like-an-elite)[ Seeing like an elite ](https://www.theargumentmag.com/p/seeing-like-an-elite) Kobe Yank-Jacobs · Sep 4 What do Americans hear when they watch Sen. Bernie Sanders or Vice President JD Vance rail against the elite? Are they thinking of right-wing tech billionaires? Imperious college professors? Liberal magazine writers? [ Read full story ](https://www.theargumentmag.com/p/seeing-like-an-elite) [ The Weekly Scroll ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline)[ God is back on the timeline ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline) Jeremiah Johnson · Sep 5 This week, we’re talking about Substack’s new religious debates, the continuing MAGA influencer scandal, how to retire from YouTube, and aura battles. [ Read full story ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline) 1 This was a legitimate thing to worry about, but doesn’t seem to be a problem given the actual technology: Marijke Van Vlasselaer, Filip Van Droogenbroeck, and Bram Spruyt’s 2026 paper looks at whether Pangram is less accurate when evaluating the work of non-native speakers of English. It isn’t. That’s because Pangram isn’t really looking at how “unusual” a piece of writing is but whether it has the characteristic patterns of LLMs. The Wired article makes an odd gesture at a different Pangram-is-racist argument. There were several controversies this summer during which upcoming books were canceled after being discovered to be AI-written: “The three novels mentioned earlier — Shy Girl, Daggermouth, and Call Me, easily publishing’s biggest AI-detection scandals — were all written by writers of color.” But come on! As Zvi Mowshowitz put it: “They were not primarily written by people of color. They were primarily written by AIs.” That’s the whole problem! And as my colleague Jeremiah Johnson recently observed with respect to Cambridge’s Arday scandal, a community being unwilling to call out fraud if it’s perpetuated by people of color is not an anti-racist tendency; it is ultimately quite racist. 2 Many non-Pangram detectors don’t work, but many possible airplane designs also don’t work, and no one considers this a general argument against aviation; the thing that matters is whether any detection works. 3 The phrase “empires have always loved” mysteriously became all the rage in the last few years. See here, here, here, here and here. Before 2025, the only use of that phrase I have been able to find is a single Tweet. The logic of the sentence, too, is incoherent in an AI-characteristic way. “...sounds like paperwork, until you remember that empires have always loved paperwork”? Does remembering that make it sound less like paperwork? It’s a craft-ful sentence, but what is it actually saying??
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