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Record-Breaking NBAA SDC2026 Powers Business Opportunities and a Bold Vision for the Future
A record-setting 3,500 attendees had an opportunity to see the full range of leading products and services on a sold-out exhibit floor over two business-driven days that also featured inspiration, innovation and powerful in-person connection at every turn throughout the 2026 NBAA Schedulers & Dispatchers Conference (SDC2026) in Cleveland.
Motorola Razr 70 Ultra leaks on high-resolution renders for the first time
The Motorola Razr 70 Ultra can be seen for the first time in high-resolution render images. Motorola's next-generation folding flagship combines a 4-inch secondary display with slim bezels with a 7-inch main display and a dual camera.
Federal ruling on UF case deals blow to state law limiting faculty dispute appeals
Court filings showed multiple professors were denied arbitration after challenging terminations and performance reviews under the law.
Democratic lawmakers highlight pay gap; business group raises concerns on wage transparency bill
Democratic lawmakers marked Equal Pay Day on Thursday by highlighting persistent wage disparities in Connecticut while backing legislation that would require employers to disclose salary ranges and benefits in job postings.
Spring Into Success: Events and Learning Opportunities to Help Small…
Entrepreneurs and business owners can discover AI tools, procurement insights and more at multiple April events.
Contract dispute could push White River Medical Center out-of-network with UnitedHealthcare
The city of Batesville is facing a looming healthcare crisis.A contract dispute between the White River Medical Center and the private insurance giant UnitedHe
Intel and LG Display may have beaten Apple and Qualcomm with the best laptop battery life ever
Over 26 hours of web browsing in one test.
Anker Smart Display 45W USB-C Foldable Charger Drops 30%, Small in Size and Smaller in Price
It's 47% smaller than most chargers, but doesn't compromise on performance.
AHA launches custom innovation summits, revamped reducing disparities in health outcomes webpage
The AHA is now offering custom innovation summits — proven, high-impact workshops designed to convene health care leaders and co-design solutions for organizations committed to reducing health disparities.
Charles County Science Fair Winners Announced Following Annual Expo
WALDORF, Md. – Charles County Public Schools (CCPS) held the 10th annual History, Industry, Technology and Science Expo, also known as HITS, on March 21 at St. Charles High School. Each year the Expo features student history and science fair projects on display for judging. Science fair project categories included behavioral/medicine and health science, chemistry, […]
Poll: 1 in 3 Adults Are Turning to AI Chatbots for Health Information, Equaling the Share Who Use Social Media for Health
About a third (32%) of adults nationally say they have turned to artificial intelligence (AI) chatbots in the past year for health information, a new KFF Tracking Poll on Health Information and Trust finds. Most who turned to AI for health information say they were in search of quick and immediate advice, though challenges affording and accessing health care also play a role, particularly for younger adults.
L'Oréal's Skinbetter Science Launches Volume-restoring Facial Serum
L'Oréal-owned, physician-dispensed skin care brand Skinbetter Science has introduced its Ampra Volumizing Macro HA Serum, meant to plump facial skin.
Democrat Emily Gregory wins Special Election for HD 87 in Palm Beach County
Campaign messaging escalated in the final stretch, with disputes over residency and political tactics.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
Braves showcase new food and entertainment at Truist Park ahead of season opener
The Atlanta Braves showcased LED lights, a World Series dirt display and a colossal burger ahead of Friday's season opener.
The real roadblock to government formation in Iraq isn’t Maliki—it’s Kurdish power politics
A dispute between Kurdish factions presents a significant structural obstacle to Iraq’s government formation regardless of who is nominated for prime minister.
Accelerating Innovative and Effective Pediatric Health Care Delivery Systems: Interventions and Value-Based Care Models for Children with Chronic Health Conditions and Complex Social Needs
Children, youth, and families have unique health needs, which set the foundation for health across the life course; chronic conditions now affect nearly one in three U.S. children, with disproportionate prevalence in those enrolled in Medicaid and CHIP.
Dimon warns on AI job losses, calls for government-business incentives
The potential AI-related disruption of the job market is a critical issue in Washington, with lawmakers trying to curb the amount of job displacement.
UT Health San Antonio Multispecialty and Research Hospital treats first clinical trial participant in novel cancer study - UT Health San Antonio
Milestone paves the way for advancements in cancer care, innovation and patient care in San Antonio and South Texas. UT Health San Antonio Multispecialty and Research Hospital has enrolled and treated its first clinical trial participant in a novel cancer study, marking a pivotal moment for science and patient-centered cancer care in San Antonio and […]
Senators consider deal to fund Homeland Security but not ICE enforcement
WASHINGTON (AP) — Senators raced Tuesday to clinch an emerging proposal to end the Homeland Security shutdown by funding much of the department, including the Transportation Security Administration airport workers going without pay, but excluding the ICE enforcement operations that have been core to the dispute. The sudden sense of urgency comes as U.S. airports […]
What growing up in an end-times church taught a science communicator about dispelling misinformation
A passion for snakes opened a crack in the religious beliefs science communicator Paul Martin Jensen grew up with in a end-times Pentecostal church.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Lithia sports facility proposal sparks heated zoning battle between neighbors, supporters
A growing dispute is unfolding in Lithia, where a proposed private youth sports complex is drawing strong reactions from both neighbors and supporters.
Entertainment and more in the Mid-Ohio Valley
PARKERSBURG – The Artsbridge calendar for this week: TODAY * Geppetto Woodcarver’s Wood Quilt display, 9 a.m. to 4 p.m., WesBanco, Market Street, Parkersburg * Art is Life/Life is Art, ages 55-plus,10:30 a.m. to 12:30 p.m., Parkersburg Art Center * Butterfly Photo Holder, ages 13-plus,11 a.m. to noon, Marietta Public Library * Hygge Club, adults, […]
Utah Sen. John Curtis helps lead push to ban sports betting contracts on prediction markets
Utah Sen. John Curtis and California Sen. Adam Schiff are leading a push to make clear that sports prediction markets are indeed gambling.
Anthropic's Claude Can Now Control Your Computer
The developer is boosting Claude's agentic capabilities in an apparent effort to compete with platforms like OpenClaw.
NIH grant terminations affected women scientists more than men, study finds
A new paper shows that women, particularly those early in their careers, have been disproportionately affected by NIH grant terminations
Antarctica could warm 1.4 times faster than the rest of the Southern Hemisphere in the coming decades, study finds
Antarctica could warm much faster than its surroundings over the next few decades due to a phenomenon known as polar amplification that is well established in the Arctic.
Emmanuel Grégoire, Socialist long involved in local politics, voted new Paris mayor; AP explains
Grégoire won over 50% of the votes, beating out prominent conservative contender Rachida Dati who reached 41% while hard-left contender Sophia Chikirou got about 8%.
Every bulb on Govee’s new outdoor string lights can display multicolor effects
Level up your patio.
Ohio lawmaker proposes election board changes after Delaware County dispute
Dispute at the Delaware County Board of Elections prompted a state lawmaker to propose changes to how county election boards work.
Samsung reverses big S Pen change for Galaxy S27 Ultra after bold experiment fails
Samsung has backed away from one of its more ambitious S Pen experiments for next year’s Galaxy S27 Ultra, choosing to stick with its long-standing digitizer-based input system after testing a radically thinner alternative. According to ETNews, Samsung had been exploring a new pen technology that could eliminate the digitizer layer inside the display. The […]
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Apple iPhone Fold Might Have A Sun Glare Problem
Given the already high reflectance of iPhone displays, Apple's use of a CoE filter on the iPhone Fold can lead to a sun glare problem.
California sheriff seizes 650,000 ballots in defiance of state officials over election count dispute
Riverside County Sheriff Chad Bianco seized over 650,000 ballots to probe alleged excess votes in California's Proposition 50 special election.
Apple Has Released More Than 10 Products and Accessories This Month
It has been a busy March for Apple, which has unveiled more than 10 products and accessories this month. However, aside from the all-new MacBook Neo and Studio Display XDR, the devices received faster chips or new colors and little else.
47th annual Utica University science fair shows area students are smarter than ever
Four dozen science projects from 60 students from eight area schools competed for the top prizes at the Donohue Concourse underneath the Frank Gannett Library. Some of the topics may have changed over the years — there were no baking soda volcanoes — but the students still displayed their projects on decorated posterboard for staff, family and the judges to see. The projects were split between the junior division — 7th and 8th grades — and the senior division — 9th through 12th grades.
Apple M5 MacBook Pro and Air Review: When the Neo Isn’t Enough
Apple’s new laptops and high-end display fit the bill for the company’s most demanding customers.
Apple Wanted to Buy Halide to Boost iPhone 18 Pro's Camera App—Now There's a Lawsuit
Apple's plans to enhance the iPhone 18 Pro's Camera app led it to consider acquiring Halide, but the talks ultimately collapsed and were followed by a fierce legal dispute between the startup's co-founders, according to The Information reports. In the summer of 2025, Apple reportedly held discussions to acquire Lux Optics, the developer behind the popular iPhone camera apps Halide, Kino, and Spectre.
Wellness expo offers financial and health resources to Allen County families
According to a press release, the free event is open to the public and seeks to help reduce health and economic disparities, in turn improving and saving lives.
Sign on shuttered Keizer store accuses Bricks & Minifigs of Lego theft
A dispute over what was once dubbed "one of the largest collections of Star Wars Lego figures in the world" led to a Keizer Police investigation.
One arrested, another cited in shoplifting incident at business on East Avenue in Chico
CHICO, Calif. - A Paradise man was arrested and a Forbestown woman was cited by Chico Police in connection to a shoplifting incident at a business in Chico.The Chico Police Department says that at around 12:30 p.m. on Wednesday, March 18, a loss prevention employee observed two suspects stealing several items from a retail business on the 700 block of East Avenue in Chico.Upon exiting the building, the two suspects, a man and a woman, were contacted by the loss prevention employee regarding the stolen items. The employee was able to persuade both suspects to return to the store and hand over the items they had stolen.Authorities say the business expressed their desire to press charges against the suspects and contacted Chico Police to report the crime.Officers reviewed video surveillance that confirmed the employee's account of what happened. Officers then made arraignment for both suspects to turn themselves in the following day.When the suspects, identified as 51-year-old Jamie Leal of Forbestown and 62-year-old Melvin Royal of Paradise, arrived the next day to turn themselves in, authorities say both admitted to their involvement in the incident and elected to write handwritten apology letters to the business.Leal was cited by Chico Police on a misdemeanor charge of shoplifting.Royal was taken into custody and transported to the Butte County Jail, where he was booked on the following charges:Shoplifting with 2+ priors (felony)Shoplifting (misdemeanor) googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Apple Has Unveiled 9 New Products This Month
Apple has unveiled a whopping nine new products so far this March, including an iPhone 17e, iPad Air models with the M4 chip, MacBook Air models with the M5 chip, MacBook Pro models with M5 Pro and M5 Max chips, the all-new MacBook Neo, an updated Studio Display, a higher-end Studio Display XDR, AirPods Max 2, and Nike Powerbeats Pro 2.
Value investors see mispriced opportunities from sports to fertilizer
Value investors pitched a mix of stock ideas in disparate corners of the market at the Value Invest conference in New York on Thursday.
Apple to Launch More New Hardware This April
Apple isn't done yet. After announcing seven new products in March – including the iPhone 17e, iPad Air, MacBook Air, MacBook Pro, MacBook Neo, Studio Display, and Studio Display XDR – the company has one more launch on the books in the coming weeks (as far as we know, at least). AirPods Max 2 go up for pre-order on March 25, with availability beginning in early April.
iPhone Fold Leak: Apple Finally Perfects the ‘Zero-Crease’ Display
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Galaxy S26 Ultra Enterprise Edition is here with advanced security features
Samsung has announced the launch of the Galaxy S26 Ultra Enterprise Edition in the UK. It comes with improved privacy and security features.
The R.I.-based pharmacy giant also owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed
CVS owns health insurer Aetna and pharmacy benefit manager Caremark, allowing it to control how medications are priced, prescribed, and dispensed.
Hispanic Women-Owned Business Growth—Revenue Hasn’t Caught Up
Hispanic/Latina women are launching businesses at record rates and leading in employer firm growth. New IWOB data shows why revenue still doesn’t match the momentum—and what changes that.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Trump administration launches investigation of states, including Mass., that mandate health insurance covers abortion
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The politics behind the SAVE Act
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Xiaomi releases new lightweight laptop with Intel Panther Lake and 120 Hz OLED display
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Dickens calls on business community to help tackle neighborhood disparities
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Pre-litigation meeting fails to resolve dispute between businesses and Black Mountain
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Large Medical Cannabis Review Finds Scarce Evidence It Treats Mental Health Disorders
We know so very little.
Mental health staff accept pay offer to end strikes
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Paleontology has an Epstein problem. Women in the field say it's a symptom of a deeper misogyny
The names of hundreds of scientists have appeared in the Epstein files, including prominent dinosaur researchers. As the paleontology community reckons with the fallout of these revelations, women in the field say it's bringing to the forefront what they've known for years — that paleontology is ripe with abuse and harassment, and its institutions protect men at the top at the expense of women trying to build careers in spaces that treat them as disposable.
Your daily coffee may be protecting your brain, 43-year study finds
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Rumor: iPhone 19e may bring ProMotion display
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Flickering Pixel 10 Pro display glitch is driving users absolutely crazy, and it's hard to unsee
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Apple Studio Display XDR Hands-On: Better Than the Pro Display XDR in Almost Every Way
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The Gemini for Home voice assistant is now more concise, faster, & better at alarms/timers
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Samsung admits Galaxy S26 Ultra’s screen quality is slightly hindered by Privacy Display
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ASUS Announces 2026 TUF Gaming Laptop Lineup
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Nintendo Switch 2 update adds one possible fix for blurry OG Switch games
Switch games running at 720p can look worse on the Switch 2's 1080p display.
Oppo Find N6 goes official with ‘crease-less’ display, but limited ‘global’ launch plans
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Identity of Banksy, Oscar-nominated graffiti artist, proven 'beyond dispute'
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Entertainment and more in the Mid-Ohio Valley
PARKERSBURG — Events and programs for the week from Artsbridge: TODAY * Geppetto Woodcarver’s Wood Quilt display, 9 a.m. to 4 p.m., WesBanco, Market Street, Parkersburg * Homeschoolers Music Class, grades K-2 and 3-5, 10 a.m. to 12:30 p.m., Parkersburg Public Library * Art is Life/Life is Art, ages 55+, 10:30 a.m. to 12:30 p.m., […]
Boost your small business with this resource fair
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Samsung Is Reportedly Offering Refunds So That Galaxy S26 Ultra Owners Do No Return Their Phones
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Regional Science Day Hosted at UToledo
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Samsung admits 'some variation' will be seen on the Galaxy S26 Ultra's screen brightness due to Privacy Display — but it should be 'negligible'
A confirmation and reality check
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The Galaxy S26 Ultra has a major display flaw that cheap Android phones solved years ago
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Here's what the Samsung Galaxy S26 Ultra's Privacy Display does to its battery life
Benchmarks and tests to see what's going on under the surface
Apple's 2026 Studio Display Hits New Low Prices on Amazon at Up to $100 Off
Apple just launched the new line of Studio Displays this month, and today Amazon has introduced the first discount on the Standard Glass model with Tilt-Adjustable Stand. You can get this Studio Display for $1,499.00, down from $1,599.00, a new all-time low price. Note: MacRumors is an affiliate partner with Amazon. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
Home for Families launches on-site mental health support for clients
Columbus nonprofit Home for Families has partnered with Hidden Roots Mental Health to bring on-site mental health services to clients.
Belinda M. Paschal covers features, entertainment for the Dispatch
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The 7430U CPU scandal could spread: Another manufacturer under suspicion, ODM comes into the spotlight
While we recently found Chuwi guilty of CPU fraud twice, there are now indications that another Asia-based brand, Ninkear, could be affected. We also have a sample of this laptop at our disposal and are investigating immediately. Spoiler: The result exonerates the manufacturer, but raises questions about the original design manufacturer (ODM).
Music legend has 24-hour nurse as health battle continues: ‘Frustrating last few years’
He said last year that he is 'very sick.'
Forging Health Partnerships Under the Trump Administration’s America First Global Health Strategy in Honduras and Senegal - United States Department of State
The United States signed bilateral health cooperation Memoranda of Understanding (MOUs) with the Republic of Honduras and the Republic of Senegal, marking significant milestones in advancing the Trump Administration’s America First Global Health Strategy while strengthening our partnerships in the Western Hemisphere and Africa. In Honduras, the Department of State signed a five-year, $46.5 million […]
Let parents, not politics decide whether Iowa's children get vaccinated
"... I'm worried that some Washington officials are deliberately confusing the public debate" over childhood vaccinations.
Galaxy S26 Ultra display causing eye strain and headache; Samsung is apparently investigating
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Trump details his shoe philosophy: ‘I have fun with it’
President Donald Trump disputed a recent report that he has bought members of his Cabinet dress shoes but then offered detailed thinking on why he has replaced top officials’ footwear, saying he doesn’t want his Cabinet sporting sneakers.
iPhone Fold’s crease-free display is about to hit major milestone, per leaker
The iPhone Fold is six months away from launching, and according to a new leak, its crease-free display will soon hit a major milestone.
Apple Clears Out M5 MacBook Pro at an All-Time Low After Its New Laptop Launch, Featuring 14.2-inch Liquid Retina XDR Display
Upgrading to a powerful MacBook has never been easier.
Hegseth’s Boasts of ‘Maximum’ Engagement Authorities Face Scrutiny After School Is Hit
The defense secretary has disparaged restrictive rules for opening fire that are aimed at reducing the risk of mistakes and civilian casualties.
Las Vegas students have Pi artwork displayed on the Sphere
The Sphere announced the winners of its third annual XO Student Design Challenge. See the artwork.
With Disputed Legal Maneuver, Trump Tries to Set Policy Without Legislation
By suing Republican states and making sharp reversals in old cases, the Trump administration is using courts to fast-track major shifts in policy.
Windows 11 gets extreme display refresh rate support and new features in KB5079387
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