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Tom Kean Finally Reveals Cause of Absence from D.C.
The New Jersey representative, who has been absent from D.C. since March, revealed in a floor speech that he was hospitalized for depression.
PAHO expands health response as Venezuela faces mounting health risks after devastating earthquakes
Caracas, Venezuela/Washington, D.C., 30 June 2026 (PAHO) – The Pan American Health Organization (PAHO) is expanding its support to Venezuela's Ministry of Health following the two powerful earthquakes that struck the country on 24 June, deploying technical experts, coordinating international Emergency Medical Teams (EMTs), assessing damaged health facilities, and mobilizing emergency medical supplies to support lifesaving care and reduce the risk of disease outbreaks.
Supreme Court upholds principle that almost all born on U.S. soil are American
If the court had struck down birthright citizenship and upheld President Donald Trump’s executive order, the ruling would have had sweeping political, economic and social ramifications.
Win Fin, Flow Fork, Speed Sniffer: Specialized launches 'fastest road bike ever made' in the S-Works Tarmac SL9
American brand draws on Formula 1 lap times software to quantify performance beyond just aero and weight
Specialized claims the new Tarmac SL9 is faster than the Colnago Y1Rs and Cervélo S5 when using "the only metric that matters"
Specialized says the new SL9 is faster than the Colnago Y1Rs, Cervélo S5 and Factor One when tested against the "the only metric that matters"
Revitalized 1930s estate in Mettawa for sale at almost $9 million
The mansion and 11-acre grounds of the estate known as Shagbark have been extensively rehabbed and updated since 2019 as a personal project of the man whose family company revitalized the former Motorola Mobility campus in Libertyville.
Premier Lacrosse League lands $100 million to chase Olympic moment
The funding comes at a crucial period of preparation for PLL, as it looks to capitalize on lacrosse being a part of the 2028 Summer Olympics.
FDA staff recommendation undercuts RFK Jr.’s push to expand peptides
The chains of amino acids are increasingly marketed for antiaging and health benefits. However, medical experts say many of those claims have not yet been fully tested.
Leading Colorado toward modern mental health solutions
By Sean Camacho America is facing a silent crisis. Millions of Americans are living with invisible illnesses like generalized anxiety disorder (GAD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD), which decrease quality of life and, amid limited treatment options, create a vicious cycle of endless medications and, for many people, hopeless therapies. This […]
Gaining biological insights through supervised data visualization
Nature Computational Science - This study introduces RF-PHATE, a supervised visualization method that preserves data structure while revealing biological patterns, enabling insights into disease...
Scientists cured sickle cell. Then their next challenge began.
Gene editing has delivered remarkable results against sickle cell disease. Now researchers are working to make these personalized treatments faster, cheaper, and available to far more patients.
Trump taps Keith Sonderling, a longtime ally of business, for Labor Secretary
President Trump nominated acting secretary Keith Sonderling to permanently lead the Labor Department after months of turmoil. Business leaders who backed his candidacy say he has already been steering policy and personnel decisions.
Colorado court rejects November ballot initiatives aimed at redrawing congressional districts
Colorado voters won’t get to decide this November on whether to change the state’s congressional districts to favor Democrats
UNC sports give you the chance to be a part of something bigger
"The more I thought about it, the more I realized how deeply sports are woven into the culture of this university. Being a UNC student means inheriting a lifetime of 'we get to’s' through sports."
Cost and utilization of inpatient mental health and substance use treatment - Peterson-KFF Health System Tracker
Approximately 1 in 5 people with private health insurance have any mental illness, and 1 in 20 have a serious mental illness. This brief examines inpatient mental health and substance use treatment admissions in 2023 among adults aged 18-64 with large employer-sponsored health insurance plans. Private insurance enrollees constitute roughly a quarter (26%) of mental […]
Gemini's personalized AI image generation is now free for U.S. users
Google is expanding Gemini’s personalized AI image generation to eligible free users in the U.S., allowing the chatbot to create images based on your interests and data from connected Google apps.
What really happened to Lizzo’s career?
The pop star is back with a new album, a new look and a lot of baggage. People aren’t buying it.
Few details known on Mitch McConnell’s health 2 weeks after hospitalization
Two weeks ago, Kentucky Sen. Mitch McConnell was admitted to the hospital. Few details about his condition are publicly known.
Essentia Health-Duluth Clinic welcomes psychotherapist Jeremy Perrett
Jeremy Perrett, a licensed independent clinical social worker specializing in psychotherapy, is thrilled to join the Essentia Health-Duluth Clinic.
Lizzo slams 'Khia Asylum' meme for 'flopping' pop stars: 'Weapon that targets only women'
Lizzo slammed the 'Khia Asylum' meme often use for 'flopping' pop stars: 'A tool to bully artists,' she said, calling the title itself 'backhanded' for mocking a 'pillar in the Black community.'
TEFCA hits 1 billion as HHS invests $1.28M in network oversight
While marking TEFCA's milestone, ONC announces a new contract to enforce network compliance. Amid ongoing legal battles over alleged network misuses, Health Gorilla CEO Bob Watson emphasizes why federalizing governance is critical to trust.
French election politics bring surrogacy back into Europe’s spotlight
The former prime minister's call to legalize surrogacy has drawn opposition from across France's political spectrum, including within his own party, with possible consequences across Europe.
Supreme Court rules mail-in ballots arriving after Election Day can be counted
A decision against such ballots could have upended election procedures in states across the country ahead of the midterm elections.
Austin Home Theater Helps Central Texas Homeowners Reimagine Entertainment With Custom Home Theater Design
Locally owned integrator combines decades of experience with personalized design to deliver cinema-quality systems across the Austin area
UC Berkeley is establishing the Nancy Pelosi Institute to address democracy's challenges
Former House Speaker Nancy Pelosi and the University of California, Berkeley, are partnering to form a new nonpartisan academic institute they say will be dedicated to strengthening democracy
Nancy Pelosi to establish new democracy institute at UC-Berkeley
The former House speaker is preparing to leave Congress after a nearly four-decade decorated career.
Kara Swisher took Silicon Valley by force. Now she's eyeing influence in the 2028 campaign
Kara Swisher is expanding her influence from tech journalism to politics
Ahead of the MLB trade deadline, here’s where the Guardians stand
The Guardians are among the best teams in a weak American League. This is the time for them to capitalize on their situation.
Medicare is about to cover GLP-1 drugs for weight loss. Here’s what to know.
The Trump administration will launch its pilot program on Wednesday. It lasts 18 months, and estimated costs to taxpayers have not been disclosed.
South Korean tech giants to build a $518 billion chipmaking hub to serve soaring AI demand
South Korean tech giants Samsung Electronics and SK Hynix plan to invest a combined $518 billion in a new computer chip manufacturing hub, capitalizing on surging artificial intelligence-driven demand.
Radford University finalizing plan to build new health sciences center on Roanoke’s Jefferson Street
The new building would house all Radford University Carilion programs, a university spokesperson said.
West Hartford Business Buzz: June 29, 2026 - We-Ha
A round-up of openings, closings, and other news about West Hartford businesses. Business Buzz is sponsored by NBT Bank, and we are very thankful for their support! By Ronni Newton I can't believe it's already June 29. It seems like it was just Memorial Day, and now suddenly we are finalizing
New US-Iran clashes revealed fragility of truce — and why it may work
An apparent agreement by the US and Iran to pause a fresh outburst of violence stabilized a truce that is the first step to permanently ending the war and underscored that each side has a vital national interest in doing so.
John Oliver scores his dream job: A soap opera gig on 'General Hospital'
The host of HBO's "Last Week Tonight" will realize one of his big wishes in July with a guest spot on the ABC soap opera "General Hospital."
India’s Yash Raj Films Backs Rusk Media in Vertical Entertainment Push (EXCLUSIVE)
Yash Raj Films has made a strategic investment in Rusk Media, the digital-first entertainment company behind the Alright! TV platform that specializes in original content for Gen Z and Gen Alpha audie...
She traveled to China to see family; different parenting styles
A visit home to China made Grace Cong Sui realize that the parenting habits she'd adopted in the US differed from those she grew up with.
She traveled to China to see family; different parenting styles
A visit home to China made Grace Cong Sui realize that the parenting habits she'd adopted in the US differed from those she grew up with.
Israeli strikes and shelling in Gaza kill at least 4 Palestinians, health workers say
Local health officials say the latest Israeli strikes across the Gaza Strip have killed at least four Palestinians, including a 13-year-old girl
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Microbusinesses celebrate New York state’s first cannabis showcase
Five years since the legalization of recreational marijuana in New York state, business owners and growers are still struggling and navigating their way through the complicated legal status and policies surrounding the cannabis industry.
Up Close: Mamdani marks big political victory in New York City primaries
Up Close: Liz Cho sits down with the political team to discuss the New York City primaries and the ongoing battle over horse carriages in Central Park.
I Just Realized Why 'Sweet Magnolias' Star JoAnna Garcia Swisher Looks So Familiar (and It Has Nothing to Do with 'Reba')
If 'Sweet Magnolias' JoAnna Garcia Swisher has you doing a double-take, you're not alone. Here’s where you’ve likely seen the actress before.
On anniversary of disastrous debate, Biden rallies Democrats at a casino
President Joe Biden spent the second anniversary of his disastrous debate performance at a Maryland casino, giving the keynote speech at an annual fundraiser for Maryland Democrats.
Science & Medicine: Scanning the brain to improve treatment for traumatized teens
Around 20% of teens who have experienced emotional trauma don't respond to talk therapy. UT Health San Antonio is using neuroimaging to track brain changes in traumatized teens during a course of therapy to see if they can figure out why, which could lead to the development of more personalized treatments that will help more teens heal.
Trump’s vision for White House park: 47 trees to mark his 47th presidency
The president has called Lafayette Square the entrance to the White House. Contractors have been renovating the park for months and are likely to miss Trump’s original goal of reopening before July 4.
With time running out, Trump digs in on changing midterm election rules
Fearing a Democratic takeover of Congress, the president has spent months trying to alter how the midterms will be conducted, but obstacles keep cropping up.
Central Mass. by the Numbers, Sunday, June 28
A look at business news in Central Mass. over the past week.
Patients can save thousands with drug coupons, but only if insurers honor them
Patients who rely on co-pay assistance from drugmakers are typically heavy users of health care for whom delays in treatment or worsening conditions can lead to higher costs, according to patient advocates.
Application deadline for 2026 RISE Up Harlingen Business Pitch Competition is July 6
The competition is a collaborative effort between the Harlingen Economic Development Corporation and UT Rio Grande Valley's Entrepreneurship and Commercialization Center.
Gunnar gives back: O's shortstop surprises local kid with specialized cleats
BALTIMORE -- The story of 11-year-old Declan Lefevre’s youth baseball career is inspirational. When Declan was about 4 years old, a doctor noticed his legs were different lengths. And it wasn’t something he would grow out of, either, which is something his parents -- father Jeff Lefevre and mother Nichole
Usha Vance pokes fun at ‘political significance’ of maternity dress
Second lady Usha Vance poked fun at a New York Times article examining the public image of pregnant women in President Trump’s orbit, joking that she did not realize her maternity dress carried so …
Scientists discover what triggers belly fat as we age
Aging may trigger the appearance of specialized stem cells that supercharge the body's ability to create new belly fat. The discovery reveals a potential biological driver of middle-age weight gain and a promising target for future anti-obesity treatments.
Pro-Israel influencers criticize Vance, but evangelicals remain open to him
Despite attacks from some conservatives, a heavily pro-Israel crowd still has warm words for Vance, with many saying they could pick him as the party’s nominee.
Jeffries Faces Steep Test as Far Left Builds Strength in Congress
The victories of Darializa Avila Chevalier and other anti-establishment candidates are changing the face of House Democrats, posing a challenge for their leader.
City of Covington awards final round of fiscal year 2026 Small Business Incentive program funding
The City of Covington continues its commitment to supporting entrepreneurs, revitalizing commercial corridors, and strengthening neighborhood business districts through the Covington Small Business Incentive Program. The Covington Board of Commissioners has approved the fourth and final round of Fiscal Year 2026 Small Business Incentive Program funding, awarding $28,000 to support four projects across the city....
Andy Burnham distanced himself from UK Prime Minister Starmer, but may be stuck with his policies
Andy Burnham has set himself apart from the man he expects to replace as British prime minister
Trump-backed Letlow faces Fleming in Louisiana GOP Senate runoff
President Donald Trump’s choice for U.S. Senate in Louisiana is seeking to secure the GOP nomination and deliver another win for the president in his effort to replace Republicans who crossed him
140 Kauai Coffee jobs saved through new land lease agreement
The lease agreement between Kauai Coffee’s parent company, Massimo Zanetti Beverage Group, and landowner Brue Baukol Capital Partners was finalized after nearly two years of negotiations
Trump tries out midterms message that focuses on ‘communists’
Trump warned an audience of religious conservatives that communism is spreading in the U.S., a new theme for his midterm campaign.
Music Legend Axes Shows After Onstage Health Scare
Lionel Richie was hospitalized on the opening night of his tour with Earth, Wind & Fire after feeling dizzy on-stage.
Why where you live matters for heart health — even in childhood - Baylor College of Medicine Blog Network
Evidence links environmental exposures to early cardiovascular risk, disproportionately impacting marginalized communities like AI/AN youth.
Seattle ups its payout for vandalized small businesses. Is it enough?
For many businesses, the reimbursement "could be the difference between someone making their rent or not, just because this is such a tough time,” said Analog Coffee's owner.
Lionel Richie is 'heartbroken' to postpones concerts after reported hospitalization
Lionel Richie is postponing two shows after cutting his St. Paul, Minn., concert short and a reported hospitalization.
Gambling disorder diagnoses spike after states legalized sports betting
Researchers analyzed millions of electronic health records and found a major difference between states that greenlit sports gambling and those that didn’t.
Gambling disorder diagnoses spike after states legalized sports betting
Researchers analyzed millions of electronic health records and found a major difference between states that greenlit sports gambling and those that didn’t.
Big Ten women’s sports are having a moment. What is the league doing to capitalize?
In the two years since Caitlin Clark left for the WNBA, the Big Ten has worked to keep its momentum.
Massachusetts marijuana legalization repeal question battle heats up
Cannabis industry leaders are urging businesses to take the initiative seriously after many previously dismissed its chances.
Medical breakthroughs collide with the health system
The buzziest advances — like personalized gene therapies or AI-discovered drugs — may not deliver.
This Democratic congresswoman almost helped elect a Republican speaker
Rep. Marcy Kaptur (D-Ohio) explains why she contemplated supporting Rep. Kevin McCarthy (R-California) in 2023 with an extremely rare crossover vote.
Hollywood gets into the microdrama race as mobile-first storytelling draws stars and major studios
Mobile-first serialized storytelling is rapidly becoming one of entertainment's fastest-growing businesses.
Tempo's Marina Mabrey ties WNBA records with 53 points and 9 3-pointers in rout of Sparks
Mabrey joins A'ja Wilson and Liz Cambage in the record books.
Vance dismisses Watergate scandal, says ‘deep state’ went after Nixon
The vice president said he admired Nixon and drew parallels between the past president, who resigned amid pressure in 1974, and Trump today.
Dopant-localized mechanoluminescence in simple oxides
Light: Science & Applications - Dopant-localized mechanoluminescence in simple oxides
Neuroimaging utilization in emergency departments has increased year-over-year for a decade
Researchers believe their new data could be used to better inform staffing coverage in modern radiology departments.
PAHO mobilizes emergency health response following earthquakes in Venezuela
Caracas, Venezuela/Washington, D.C., 25 June 2026 (PAHO) – The Pan American Health Organization (PAHO) has activated its emergency response mechanisms to support the health response in Venezuela following two magnitude 7.5 earthquakes that struck the country on June 24.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
After wins by democratic socialists, centrist Democrats unite to push back
Thirteen Democratic House members and candidates announced their support for an initiative that commits them to centrist principles.
Three RWJBarnabas Health Hospitals Recognized Among Newsweek's Best Hospitals for Specialized Care for 2026
Robert Wood Johnson University Hospital (RWJUH), Cooperman Barnabas Medical Center (CBMC) and Robert Wood Johnson University Hospital Somerset (RWJUH Somerset), all RWJBarnabas Health facilities, have been recognized among Newsweek's America’s Best Hospitals for Specialized Care 2026.
Lizzy Caplan, John Stamos Movie 'Drag' Gets Winter 2027 Release
Briarcliff Entertainment has dated the Danny DeVito produced 'Drag' starring Lizzy Caplan, Lucy DeVito and John Stamos for Jan. 29, 2027.
Original 'Drag Race' star reportedly hospitalized in critical condition after fatal car crash
'RuPaul's Drag Race' season 1 queen David 'Jade' Sotomayor reportedly hospitalized after a fatal car crash in Chicago, with Monica Beverly Hillz telling EW she wants fans to send the family 'good vibes.'
Lionel Richie reportedly hospitalized after medical incident forced concert to end early
Lionel Richie has reportedly been hospitalized after a medical incident on stage forced him to sit down to sing a song on the opening night of his tour with Earth, Wind & Fire.
RFK Jr. urged Iowa candidate to make deal to help GOP win House seat, per audio recording
The health secretary urged Iowa Libertarian candidates to drop out of key races to help Republicans keep control of Congress, according to interviews and a recording obtained by The Post. The effort highlights mounting GOP anxiety over the battle for the House.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Federal court blocks Trump’s executive order limiting mail ballots
The ruling comes a month after another judge allowed Trump’s order to stand. The latest ruling sidelines major provisions of the order despite the earlier ruling.
Supreme Court lets Trump end temporary protections for migrants
The decision could allow the government to deport hundreds of thousands of people starting this year.
Largo to launch open-container entertainment district near new City Hall
The city of Largo is establishing a specialized entertainment district that allows visitors to carry alcoholic beverages outdoors by the end of the summer.
New entertainment zone allows alcohol to-go
The city of Largo is establishing a specialized entertainment district that allows visitors to carry alcoholic beverages outdoors by the end of the summer. FOX 13's Blake DeVine reports.
Elizabeth Warren says ‘frenzy’ of mergers under Trump could be reversed
Senator warns of ‘tsunami of anger’ against big companies and suggests future administrations may undo key deals
Under pressure from Trump, Republican-led Senate reverses course on Iran
The chamber rejected a resolution to force Trump to end the war after he criticized Republicans for undermining his administration’s negotiations.
As Trump kicks off state fair festival, he once again says Iran war is ‘done’
The president made his declaration before a mix of locals and tourists at a scaled-down version of the event after some performers canceled.
Sen. Elizabeth Warren: ‘Thank you Donald Trump’ for the issue that will decide the midterms
NATO’s Leader Makes His Case to Trump for Preserving the Alliance
Using charts, Secretary General Mark Rutte appeared to defuse the president’s anger by showing that European countries were “equalizing” defense spending with the U.S.
In 3-game healthcare series, underdog large-language models sweep specialized AI powerhouses
Pitting three multipurpose LLMs against two healthcare-specific AI tools, researchers have discovered the consumer-level AI can beat its purpose-built counterparts in healthcare scenarios—and soundly, at that.
Liverpool signs find a way to support business
EAST LIVERPOOL-As part of the revitalization process for the historic downtown area in East Liverpool, two wayfinding signs have just been installed in the downtown area to help direct people walking through downtown to businesses located in the area. The wayfinding signs, which have smaller directional signs on them pointing out the locations of multiple […]
Ryman Hospitality Properties, Inc. Addresses Recent Media Reports Regarding Opry Entertainment Group
NASHVILLE, Tenn., June 24, 2026 (GLOBE NEWSWIRE) -- Ryman Hospitality Properties, Inc. (NYSE: RHP) (the “Company”), a leading lodging and hospitality real estate investment trust that specializes in group-oriented, upscale convention center resorts and entertainment experiences, today addressed recent media reports regarding the Company’s Opry Entertainment Group (“OEG”) business. Colin Reed, Executive Chairman of Ryman Hospitality Properties said, “We are incredibly proud of our OEG business an
Colombia's vote may reshape the Amazon's future as political winds shift across Latin America
Abelardo de la Espriella, set to be Colombia’s president, has intensified debate over the future of the Amazon
The Trump administration has attacked science 574 times. Track each instance with this online tool
The Union of Concerned Scientists is aiming to visualize the scale of the president's anti-science actions, from censorship to the sidelining of experts.
The 17 best popular science books of 2026 so far
The first six months of the year have brought us popular science reads on everything from consciousness to cosmology. Liz Else rounds up her favourites
They poured fortunes into trying to join Congress
Of the most expensive self-funded congressional campaigns since 2000, only four out of 20 were successful.
As Ebola cases surge above 1,000, experts say outbreak could be worst ever
Insufficient contact-tracing and the refusal of many residents to avoid contact with the bodies of loved ones killed by the Ebola virus are accelerating the epidemic.