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Baton Rouge General's Health Tip of the Week: Another sugar substitute raises heart concerns
Sponsored by Baton Rouge General Cutting back on sugar? Take a peek at the ingredient label before reaching for a sugar-free treat. Recent research has raised questions about xylitol, a sugar alcohol found in products like gum, candy and baked goods. Higher blood levels of xylitol were linked to a greater risk of heart attack […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Colombia business association labels hydrogen a $20bn ‘investment opportunity’
The National Business Association of Colombia (ANDI) believes the country’s hydrogen sector is an “investment opportunity worth over $20bn,” saying a pipeline of announced projects could attract enormous capital.
T-Pain sues Akon’s record label, claiming unpaid royalties
Atlanta rapper T-Pain is suing Konvict Entertainment, the record label co-founded in Georgia by singer Akon, claiming almost $500,000 in unpaid royalties from music sales.
Patriots’ Mike Vrabel Opens up on Seahawks’ Jaxon Smith-Njigba
New England Patriots head coach Mike Vrabel addressed Seattle Seahawks star wide receiver Jaxon Smith-Njigba before Week 1. The post Patriots’ Mike Vrabel Opens up on Seahawks’ Jaxon Smith-Njigba appeared first on HEAVY.
Bengals’ Al Golden Makes Bold Claim About Rookie Cashius Howell
The defensive coordinator is already labeling the rookie speed rusher a home run after he stunned veterans in camp, signaling a potential shift in Cincinnati’s defensive hierarchy.
Lee Health uses federal grant money to expand rural offerings in SWFL counties
A $1.95 million infusion from the $50 billion Rural Health Transformation Program initiated last year will expand the Labelle site to include a walk-in urgent care clinic and a medical lab.
Stanford study finds mental health warning labels on social media may reduce teen use
Warren County’s ‘other’ party says political labels mean less and less
Looking at the political history of Warren County, one could be forgiven for thinking anyone other than Republicans voted there. It’s been four years since anyone with a ‘D’ next to their name ran for a countywide office, and decades since a Democrat held a county position.
Indian health activists lodge concerns about food warning proposal in court
Indian activists spearheading calls for food labelling said a government proposal to have red warnings only when two concerning nutrients are high created an "industry-friendly loophole" disregarding public health, marking the first formal court objection to the plan.
Indian health activists lodge concerns about food warning proposal in court
By Aditya Kalra NEW DELHI, Sept 7 (Reuters) - Indian activists spearheading calls for food labelling said a government proposal to have red warnings only when two concerning nutrients are high created an "industry-friendly loophole" disregarding public...
Indian health activists lodge concerns about food warning proposal in court
By Aditya KalraIndian activists spearheading calls for food labelling said a government proposal to have red warnings only when two concerning nutrients are high created an "industry-friendly loophole" disregarding public health, marking the first formal court objection to the plan.India's proposal…
Chaotic meeting began with attempt to squelch public comment
When Attorney General Phil Weiser takes the governor’s office in January, he must immediately address the chaos of the latest round of appointees to the Colorado Parks and Wildlife Commission to assure stakeholders he’s willing to put pressure on the bleeding wound. The keys to the kingdom have fallen into the wrong hands and Weiser […]
The science behind the beauty business
Some of Europe’s industrial champions may be in retreat, but its cosmetics sector remains a global leader, buoyed by healthy demand, recognised brands and a reputation for innovation."The fact is, the science in cosmetics is better here in Europe than anywhere else in the world,” says Pierre Morvan, CEO of Technature, a private label cosmetics manufacturer located near Brest in France’s northwestern Brittany region. “You have to have good science in order to make the difference, and that is why we invest so much in research and innovation.”Across Europe, the beauty and skincare products sector supports an estimated 3.6 million jobs, including 265,000 employed directly in the industry, according to the Cosmetics Europe trade group.. Cosmetics production contributes an estimated €11 billion to the EU economy, and generated €30 billion in export revenue last year, a €400 million rise from 2024.Technature itself has a global footprint, supplying products for 1,500 brands in 65 countries. Its range of skin gels, facial masks, nail treatments and other products include natural ingredients and extracts derived from plants, such as seaweed, that are developed and refined through science-based analysis and testing.While industry projections point to sustained growth for the foreseeable future, driven by emerging economies and wider availability of exclusive brands that were once chiefly sold by high street retailers, the sector is not immune to the impact of geopolitics and trade wars. The Trump Administration’s tariff threats have dented cosmetics exports to the EU industry's largest overseas market. After the European Parliament approved the EU-US Turnberry Agreement in June, setting a 15% levy on many EU goods, the French Federation of Beauty Companies warned that “exports are falling sharply” and urged the EU to negotiate an opt-out for cosmetics.Technature’s CEO flags South Korea as an emerging competitor, partly due to its assertive marketing efforts. “I would have to say I am a little bit scared,” Morvan says, regarding the growth potential of the South Korean cosmetics industry. “This is why science and innovation are so important if Europe is to remain the leader.”With a workforce of 200, including biologists, chemists and other scientists, around 15% of Technature’s staff work in three research and development (R&D) labs. A similar number work in four quality control and assurance facilities, where science plays a crucial in ensuring product safety in a sector that is subject to the European Cosmetics Regulation.Educational exchange between industry and academiaIn recognition of Technature’s research and innovation, Morvan was selected as one of Brest’s ambassadors to Science Comes to Town (SCTT), a European initiative to strengthen communications and understanding between science and society. Brest is one of three coastal cities in the EU-funded programme, alongside Split (in Croatia) and Kiel (in Germany). From 7-11 September, Brest will host the EU TalentOn contest featuring 100 early-career researchers from across Europe.Morvan appreciates the value of engagement with educational and scientific institutions as well as the home community. For instance, Technature collaborates closely with university partners to enhance its in-house R&D. In addition, it invites students to its labs and sends its own researchers to local institutions. "We absolutely want the students to know what the industry is all about,” Morvan says, noting that seeing science in action can help young people “understand that they can do something real with science, to create something with what they are learning.” He says another important benefit: encouraging new generations of young people to consider a career in cosmetics.Community involvement also raises awareness about Technature and the skincare industry as a whole. “The public gains recognition of the innovative company that we are, and this is important for getting new customers,” Morvan says. One of its recent innovations — tiny, colourful cosmetic pearls that release skin moisturisers on application — was showcased at this year’s VivaTech event in Paris.Morvan holds a master's degree from the Brest Business School and studied animal production and biology in Brest at the University of Western Brittany (UBO), an SCTT partner, and at the University of Tours. He got his start in business in 2002, initially working on using seaweed as a raw material in the food industry before transitioning to cosmetics. Morvan has always been interested in connecting science and business, reflecting one the goals of SCTT to enhance public-private collaboration.The invitation to participate in SCTT was unexpected. “It was a surprise to get a call from the city of Brest saying that they wanted me on this programme,” Morvan recalls, adding that officials were drawn by his company’s R&D. “It's not only theory and science fundamentals. Our science is something that is applicable to the global market — and important for the community.”Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
Everyone wants to win working-class voters. But have they realized many are women?
This story was originally reported by Chabeli Carrazana of The 19th. Meet Chabeli and read more of their reporting on gender, politics and policy. Congressional candidate JoAnna Mendoza can quickly rattle off prices from the grocery store in the small town of Eloy, Arizona, where she grew up. A couple of months ago, a pound […]
Patriots’ Mike Vrabel Gives True Thoughts on Seahawks’ Jadarian Price
The New England Patriots had no answer for stopping the Seattle Seahawks‘ running game in Super Bowl LX. Kenneth Walker III ran for 135 rushing yards in the win. However, for this Week 1 opener, the Seahawks won’t have Walker, but they will have rookie running back Jadarian Price.Last season for the Notre Dame Fighting Irish, […] The post Patriots’ Mike Vrabel Gives True Thoughts on Seahawks’ Jadarian Price appeared first on HEAVY.
China’s $25b microdrama industry faces AI upheaval
The country’s wildly popular microdrama industry is undergoing a dramatic upheaval thanks to artificial intelligence – with a very real human cost.
LeBron James Joins Polymarket as Prediction Markets Court Sports' Biggest Stars: Here's What We Know
On Saturday, four-time NBA champion and four-time Olympic medalist LeBron James announced an upcoming partnership with Polymarket, the prediction market platform. James posted a 14-second video on X showing him exiting an elevator at “Polymarket HQ,” with floor buttons labeled...
Mike Vrabel could get involved with Christian Gonzalez contract talks
Patriots coach Mike Vrabel doesn't typically get involved in contract talks, but that could change with the Christian Gonzalez situation.
Mike Vrabel Sends Blunt Message About Patriots’ Seahawks Rematch
Mike Vrabel identified three areas the Patriots must improve to avoid another painful result against the Seahawks.
Marshall Health Network awarded Rural Health Transformation Program Grant for workforce health initiative
CHESAPEAKE, W.Va. – Marshall Health Network’s (MHN) proposed Worksite Clinic Expansion Initiative was among the first grants awarded yesterday through the State of West Virginia’s Rural Health Transformation Program. A $612,000, one-year grant awarded to the Cabell Huntington Hospital Foundation will support Marshall Health Network in launching an innovative workforce health model to improve health […]
Trump says Iran conflict, which has killed 18 US service members and injured hundreds more, is ‘small potatoes’
President Donald Trump on Friday labeled the Iran war “small potatoes,” the latest attempt to minimize a six-month conflict that caused a spike in gas prices and led to the deaths of 18 American service-members.
Global Business Travel Group (GBTG) to Be Acquired for $9.50: What Investors Should Know
Gabelli Investment Management Firm recently released its “ABC Fund” second-quarter 2026 investor letter. A copy of the letter can be downloaded here. The Fund benefited from a favorable merger-arbitrage environment in the second quarter of 2026, as global announced M&A value reached a record $2.85 trillion in the first half of the year, up 50% […]
Abdul El-Sayed is the latest Muslim candidate to labeled an anti-American extremist.
The bigoted rhetoric against Muslim American politicians is backfiring
Mike Vrabel dodges question about findings in Dianna Russini investigation
Mike Vrabel had no interest in dicussing The Athletic's findings in its investigation into Dianna Russini.
Dianna Russini-Mike Vrabel Investigation Details: The Athletic Reveals Findings Following Scandal
On Thursday, The Athletic released its findings from an internal investigation into Russini's reporting and relationship with Vrabel.
Berkshire Hathaway AI strategy: Greg Abel bets on data-center power
Greg Abel explains Berkshire's Alphabet bet, data-center power plans, and cautious view of the US housing market.
Decagon on Saturn’s South Pole (Single Filter)
A single filter from NASA’s Hubble Space Telescope distinctly shows a 10-sided wave encircling Saturn’s south pole, labeled “decagon”.An “X” denotes where data was not captured.
Inside the gutsy, defiant Lucas Museum of Narrative Art
By discarding artistic hierarchy of any kind, the Lucas Museum of Narrative Art is stepping into an ongoing debate about what kind of work gets to be labeled "art."
Dem megadonor among 400 Jewish Michiganders labeled AIPAC insiders for denouncing El-Sayed's leftist campaign
Over 400 Michigan Jewish Democrats signed a letter backing Mike Rogers, but former Rep. Andy Levin claims AIPAC is really driving the effort.
Berkshire CEO Abel sees opportunity for energy business from AI
Berkshire Hathaway Chief Executive Greg Abel said on Wednesday he sees significant opportunities for the conglomerate's energy business from the buildout of AI data centers, after Berkshire made Google parent Alphabet its third-largest common stock holding.
Berkshire CEO Abel sees opportunity for energy business from AI
NEW YORK, Sep 2 (Reuters) - Berkshire Hathaway Chief Executive Greg Abel said on Wednesday he sees significant opportunities for the conglomerate's energy business from the buildout of AI data centers, after Berkshire made Google parent Alphabet its ...
AMC Theatres Gets Into Distribution Business, Launches Leawood Films
AMC Theatres, the world's largest exhibitor, is getting into the distribution business launching Leawood Films, a label for small and mid-sized films.
Instagram puts new limits on undisclosed AI profiles
As frustration over AI influencers has been growing, Instagram is limiting the reach of undisclosed AI profiles.
'Furious' finale explained by Liz Meriwether, Emmy Rossum, and Lola Petticrew
Who killed Isabel? What happened to Jay? And what's next for Alice? Let's dig in.
Private property rights challenge rural Colorado communities
If there were ever a topic I believe deeply in, it’s private property rights. If there were ever a topic that leaves me in a moral conundrum more often than not, it’s private property rights. The northern portion of Weld County is where towns like Grover and Hereford are hunkered down against the wind. It’s […]
Google is getting flak for changing Lake Ontario name to Lake America
Canadian politicians are also scrubbing government websites that embed Google Maps to ensure the lake is labeled Lake Ontario.
Four popular supplements that science says don't deliver
Walk into the supplement aisle and you’ll find plenty of products promising better health. But sometimes, basic chemistry and biology tell us those claims simply don’t add up. Before spending money on the next supplement promising better memory, faster recovery, or improved health, look beyond the label and examine the evidence.
Star Entertainment (ASX SGR) casino operator reports $307.3 million loss
The casino and hotel giant is separately facing a fine of $400 million next month for anti-money laundering failures, putting more pressure on finances.
Four Quick Thoughts on Patriots Initial 53-Man Roster Cutdown
Expect the team to be active and as coach Mike Vrabel said, "fluid" with the roster as the opener approaches on Sept. 9.
‘Metal Gear Solid: Master Collection Vol.2’ Is Worth It For ‘Ghost Babel’
Now that the second volume of the 'Metal Gear Solid: Master Collection' is finally here, the real star of the show is the Game Boy Color game, 'Ghost Babel'.
Jelly Roll explains political beliefs after Trump roasts: I’m ‘down the middle’
Jelly Roll, whose real name is Jason DeFord, made jokes throughout the week about President Trump, causing many of his supporters to label the artist a “traitor.”
Patriots Cut Former Chargers RB Ahead of NFL Roster Deadline
The New England Patriots gave Hassan Haskins a reunion with Mike Vrabel earlier in August. It lasted just 17 days.New England released the veteran running back Saturday as it continued trimming its roster ahead of the NFL’s 53-man deadline. ESPN’s Mike Reiss reported the move on Aug. 29, hours after the Patriots added another option […] The post Patriots Cut Former Chargers RB Ahead of NFL Roster Deadline appeared first on HEAVY.
Was Dolly Parton a feminist? She wouldn’t say it, but fans heard it — in her life and her lyrics
Dolly Parton never embraced the feminist label, but her actions and lyrics spoke volumes.
Family-friendly fun, outdoor adventures and live entertainment: Weekend events across mid-Michigan
Whether you're looking for educational programs, outdoor experiences or evening entertainment, communities throughout Bay, Saginaw, Midland and Isabella counties are hosting events throughout the weekend.
Judge says Pentagon's measures against Anthropic were 'illegal and baseless'
The government labeled the company a supply chain risk earlier this year
Judge says Pentagon's measures against Anthropic were 'illegal and baseless'
The government labeled the company a supply chain risk earlier this year
Mike Vrabel addresses Christian Gonzalez’s contract frustrations
Patriots coach Mike Vrabel commented on star cornerback Christian Gonzalez's contract frustrations.
Mike Vrabel's blunt reaction to Patriots' blowout loss to Browns
Patriots coach Mike Vrabel was clearly frustrated after the team's disappointing effort in Thursday's preseason finale.
Cath lab procedure kits recalled due to ongoing safety concern
The manifolds inside these kits have been linked to a significant risk of contamination. The FDA is urging users to place a warning label on each kit.
Adam and Eve store sues Fort Bend County over sexually oriented-business label
An Adam and Eve store in the Richmond area is suing Fort Bend County after being forced to register as a sexually-oriented business.
Alleged Foldable iPhone Motherboard Photos Surface Online
Images and video claiming to show circuitry from Apple's upcoming foldable iPhone are circulating on X and Chinese social media platforms. For example, on X, the user "LusiRoy7" posted a short video alongside an image, as well as a labeled composite image identifying components, purportedly depicting the motherboard of Apple's foldable iPhone. The image appears to show the CPU, a hinge connector, a flex cable connector, and more.
Cinq à Sept Built a $200 Million Business. Now It Wants Your Attention.
The 10-year-old label has built a thriving womenswear business that outsells buzzier competitors. Its next goal is to grab some of that buzz for itself.
Apple Quietly Refreshes Magic Keyboards
Apple today quietly introduced updated Magic Keyboard models with revised U.S. English key labeling. On the new keyboards, the tab, caps lock, shift, return, and delete keycaps are labeled with glyphs rather than edge text. On the full-size models with a numeric keypad, the change goes further, with the home, page up, page down, end, clear, and enter keys also swapping their text labels for symbols.
Acknowledgments
This report is a collaborative effort based on the input and analysis of the following individuals. Find related reports online at pewresearch.org/science. Primary research team Eileen Yam, Director, Science and Society ResearchGalen Stocking, Associate Director, Science and Society ResearchBrian Kennedy, Senior ResearcherGiancarlo Pasquini, Former Research AssociateEmma Kikuchi, Research Analyst Isabelle Pula, Former Research Assistant Editorial and […]
Chaka Khan resists ‘straight icon’ label: ‘How do you know what the f--- I am?’
Chaka Khan pushed back against being labeled a ‘straight icon’ in a new interview: ‘How do you know what the f--- I am?’ she asked, adding, ‘I don’t ever share that part of my life.’
Mike Vrabel reveals three unexpected Patriots standouts vs. Eagles
Patriots coach Mike Vrabel noted three players who stood out to the coaching staff in Saturday's preseason win over the Eagles.
Nate Bargatze Launches No Pictures, Sets Lawrence Grey To Oversee “Edgier” Production Label Alongside Family-Friendly Nateland Entertainment
EXCLUSIVE: After setting the Guinness World Record for most tickets sold on a stand-up tour, Nate Bargatze is continuing to expand his business — this time, in an unexpected direction. As he continues...
Nate Bargatze Launches No Pictures, Hires Lawrence Grey In Exec Role
Nate Bargatze has launched No Pictures, hiring Lawrence Grey to oversee both Nateland and the new production label as Chief Content Officer.
As Democrats Struggle in Some Western States, Independents See an Opening
From South Dakota to Alaska, independents are challenging incumbent Republicans and eschewing a Democratic label that Western voters find toxic.
Livestock grazing regulations need flexible updates
The Bureau of Land Management last updated their livestock grazing regulations the year I graduated from high school. I am 49. Assessing rangeland health can’t be done once and not revisited. This year is a prime example that managers must be able to make decisions not just year by year, but week by week. This […]
Building the beat: How New Orleans can grow the business behind the music
People dance to the music of the TBC Brass Band Photo by Michael DeMocker / The Times-Picayune This week New Orleans hosts the annual Cutting Edge CE Conference, which brings together members of the music industry, musicians, lawyers and others to learn about and discuss the latest changes in the business of making, producing and selling music. googletag.cmd.push(function() { googletag.display('ad-1492300'); }); The conference comes as AI and streaming are causing upheavals in the industry. Meanwhile, we’ve seen at least a partial collapse of the global festival industrial complex which has long been a key financial lifeline for many artists.All of that can feel a bit removed from life in New Orleans. After all, we are a city filled with music. On any given day or night, there are dozens of shows across the city, ranging from jazz and blues to hip-hop, bounce and house. Whereas in other cities kids dream of being the star of their local sports team, in New Orleans more often than not they dream of leading their own band.And music is a huge part of our economy. Before New Orleans was known as a foodie destination, it was already drawing millions of visitors from around the globe to experience our jazz, soul and funk scenes firsthand.But the reality is, if you want to make it big, you’re probably going to end up leaving the city. We’ve seen major performers like Lil Wayne, Master P and Jon Batiste (though he’s back on the Northshore) decamp to Los Angeles, Miami and New York. Likewise, up-and-coming musicians like Greer Grimsely, $leazy EZ and Lucky Daye have also left town in search of more profitable pastures.Meanwhile, our local universities train some of the best producers and engineers in the business — only to see them head to one of the big music industry cities after graduation.It’s not a new phenomenon, though the reasons have changed over the years. Like a lot of early jazz musicians, Louis Armstrong famously left New Orleans, first for Chicago before ultimately settling in New York City. But while those early migrations had more to do with racism, in today’s day and age, musicians end up leaving because New Orleans doesn’t have the industry infrastructure necessary to sustain the kind of growth and, well, success, a lot of folks dream of.It’s a hard, but very real, truth. Artists have to go to Nashville for publishing, Los Angeles for production, Atlanta to join a label or New York for representation. That, in turn, is a drain not only on the city’s talent pool but on money that could be staying here at home.Not being an industry town inevitably makes it that much harder for musicians who don’t leave to get the recognition and success they deserve. It also undoubtedly plays a part in keeping the wages working musicians in New Orleans make at their gigs here lower than in places like Austin or Nashville.That’s not to say we don’t have any of the infrastructure needed to make New Orleans a music industry town. We’ve got live music venues, studios, record labels, management companies, copyright attorneys ... all the various building blocks are there. We just haven’t ever built upon that solid foundation. googletag.cmd.push(function() { googletag.display('ad-1492297'); }); The question is how do we do that in a way that supports our existing industry and artists, respects our cultural traditions and ensures the wealth generated is equitably distributed so it isn’t just C-suite executives who end up reaping the benefits. And the time to start figuring out the answers is now: next year the legislature will focus on taxes and spending, making it vital that New Orleans leaders have a plan to try and secure funding to help grow our industry.So we asked a group of New Orleanians to give us their thoughts, ranging from industry attorneys and venue operators to working musicians and cultural advocates. Their answers point toward turning New Orleans into a music industry city without leaving musicians behind or abandoning what makes us the greatest music city on earth.If a dusty city like Austin can transform itself into a major hub not just for music but the industry behind it, surely the birthplace of jazz — and pretty much all modern music by extension — can figure it out as well. +3 Mailbox Money: The Recording Academy’s Reid Wick on supporting, and growing, New Orleans’ music industry Reid Wick has been a part of the New Orleans music landscape from virtually every angle. He'… California Dreaming: Pell discusses his time in L.A. and how New Orleans can help young musicians In 2015, New Orleans-born rapper Pell decided to make the move to Los Angeles. He was fresh … +2 Up from the street: To build a stronger music industry, support community first. At MaCCNO, most of our team aren’t just advocates, we’re also working musicians. Here are a … +2 Live and direct: Public investment in independent venues is key to a robust music economy. I’ve spent most of my adult life looking at the New Orleans music business from every side o… +2 Helping Hand: New Orleans doesn’t need more talent. It needs more infrastructure. People love to call New Orleans a music town. And they’re right. +2 \We out here: New Orleans doesn't need to be Austin. It's already a music industry city. +2 Futureshock: New Olreans has the music talent. Now it needs the innovation. New Orleans has long been known as a place for music creation and innovation. People travel … .donate-gambit-article-module-container { text-align: center; padding: 10px; /* background-color: #24da6d; */ background-color: rgb(153, 0, 0); margin-bottom: 20px; } .donate-gambit-article-module-title { font-weight: bold; color: #fff; } .donate-gambit-article-module-copy { color: #fff !important; font-size: 16px; } .donate-gambit-article-module-button { background-color: black; width: 50%; border-color: black; font-size: 16px; } .donate-gambit-article-module-button:hover { background-color: black; } @media only screen and (max-width: 600px) { .donate-gambit-article-module-button { font-size: 14px; width: 100%; } .donate-gambit-article-module-copy { font-size: 14px; } } BECOME A GAMBIT MEMBER AND JOIN OUR KREWE TODAY For more than 40 years, Gambit has covered New Orleans, for New Orleans. We’ve stood up to city hall with you, cheered the Saints with you, danced in the streets with you and cried over our collective loss with you. And we’re plannin’ on being here for 40 more. To do that, we need your help. Become a Gambit member today and help us continue our mission SUPPORT GAMBIT
Janie Bradford Dies at 87: The Songwriter Who Helped Build the Motown Sound
Janie Bradford helped build Motown from its earliest days, co-writing enduring hits, working with some of the label’s biggest stars and later investing in the next generation of performers.
DECISION 2026: Political labels are everywhere in 2026 campaigns. But what do they actually tell voters?
WEAU political analyst John Frank says much of today’s political labeling is campaign strategy as Pew research shows voters’ beliefs are more complicated than red versus blue.
Mike Vrabel addresses Drake Maye, starters’ preseason finale status
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AI needs science’s search history
“Actually, that’s where the gold is,” said Alasdair Russell, my graduate school friend who leads a pre-clinical genome editing group at Cambridge. He was talking about the winding road of science that is omitted from published papers. “When you’re discussing how to do the experiment, and why this way is better than another way, and what does the data really mean? I know what it shows, but what does it mean?” At RAAIS 2026, he described how his group has begun logging the twisting path of discovery as it happens, recording the verbal and written exchanges that normally disappear. Ideas become nodes in a living graph: they branch when a meeting produces two plausible experiments, merge when separate lines of evidence converge, and go dark when someone quietly stops pursuing them. In his implementation, one agent scores novelty, while another tries to learn “how scientists think and how they navigate through a complex world of data,” so that high-potential nodes can trigger deeper investigation. As frontier AI labs deploy agents toward scientific discovery, giving AI authentic scientific taste remains a trillion-dollar dilemma. The bottleneck is that the record we have kept for centuries of science might be insufficient to get us there. The experiments that never make the paper Peter Medawar, 1960 Nobel laureate and “father of transplantation,” asked in 1963 whether the scientific paper was a fraud, and answered yes: the form of the paper misrepresents the thinking that produced it. Sixty years on, the diagnosis is unchanged. A paper presents a clean progression from hypothesis to result to conclusion. Lost along the way are the unconventional theories, the abandoned or unaffordable methods, and the underwhelming and inconclusive data. It reads like a browser history with every dead end deleted: the ten open tabs, the four rephrased queries, the wrong turn down a subforum. All scrubbed, leaving one clean path from question to answer as the canonical path. What has changed since then is that the discarded material is now worth something. No high-impact journal wants these artifacts, but raw trial and error is the most likely source of the training data required to develop scientific intuition, or what researchers call taste. Earlier attempts to capture the discards were motivated by scientific integrity. The Journal of Negative Results in Biomedicine launched in 2002 to publish rigorous studies that disputed established models or exposed ineffective treatments. Its archive preserved negative conclusions after they had become papers, rather than the live alternatives and arguments that produced them. BioMed Central closed it in 2017, saying the mission had been served now that other journals publish null results. A less generous reading is that in fifteen years it published around 200 papers because almost nobody wants to read a negative result, let alone write one up when it will not count toward academic tenure. AI models are different. Even an uninteresting negative result can be useful, provided it is labeled. Earlier this year, Anthropic put a version of this to the test. The company pulled 129 decision points from real Claude Code sessions between January and March 2026, showed models the work up to a human detour, and asked what should happen next. Claude Mythos Preview beat the human choice 64% of the time, while Opus 4.5 managed 51%. The comparison was tilted toward the models because Anthropic deliberately chose moments where the human decision had room for improvement. On 127 further scenarios where the human action was already strong, the models improved on it only about 20% of the time. The study was possible because Anthropic’s researchers work inside a tool that logs by default. The reasoning, detours and outcome are produced in the same working environment. Biology has no equivalent. Its reasoning happens in hallways, at benches, in Slack threads and on whiteboards, while the outcome arrives weeks later somewhere else. The record has to emerge from the work itself. Ask scientists to reconstruct it afterwards and we’ll create another polished account. Subscribe A log is not a label Before any of this becomes training data, a negative result has to say what failed. The first paper published in the Journal of Negative Results in Biomedicine examined 234 negative studies across five leading medical journals. Only 30% discussed statistical power, and half clearly defined a primary outcome. Tell a model an experiment failed, without telling it whether the assay was underpowered, a reagent had degraded, or the hypothesis was simply wrong, and it will learn noise with confidence. Decision histories have a second missing label too. When a lab considers five experiments and runs one, only the chosen branch returns an outcome. The other four are experimental counterfactuals. Researchers call this the selective labels problem: the data reveal results only for the actions someone chose to take. Such a record can teach a model to imitate a lab’s taste, but it cannot establish that the taste was good. It also smuggles local constraints into general lessons. A lab that never ran cryo-EM because it did not own a microscope teaches a model that cryo-EM is rarely the right call. Alasdair’s nodes preserve the candidate set, which is the necessary first step. To be useful, each decision record needs six fields: The evidence available at that moment, and nothing that arrived later. The candidates considered, including the ones dismissed in a sentence. For each candidate: the expected result, the confidence attached to it, and the cost in time and money. The route chosen, and the reason. What happened next. How the evidence changed the scientist’s view. These must be timestamped before the outcome, because hindsight turns uncertainty into inevitability. Disagreement also has to survive. Averaging three scientists into one clean rationale reproduces exactly the information loss we are trying to fix. But there is an obvious failure mode here. Once decisions are logged and scored, people log for the record post-facto. Anyone who has watched an electronic lab notebook fill up with retrospective tidying knows how quickly a research tool becomes a compliance exercise. A record that costs a scientist ten minutes of honest reflection per decision is worth far more than one that costs an hour of performance. A publication initiative called Registered Reports offers a useful starting point. Here, researchers submit their rationale, methods and analysis plan for peer review before the data exist, and the journal commits in principle to publish if they follow the approved plan. Nature has now expanded the format across every field it covers. This approach to paper writing timestamps intent before the outcome, but it freezes one plan. A useful search history must also preserve how the plan changed, which alternatives were rejected, when, and on what evidence. Subscribe Run the runner-up Autonomous labs show what happens when decisions and outcomes are connected in a loop. Liverpool’s mobile robotic chemist ran 688 experiments over eight days in a ten-variable formulation space. A batched Bayesian search used each result to choose the next experiments and found photocatalyst mixtures six times more active than the starting formulations. Every completed experiment changed what the system did next. The robot optimized within a goal and search space that humans had already chosen. It did not decide which scientific question mattered. So what this work demonstrates is narrower, but still useful: a search history pays off when the options return standardized outcomes quickly. Open-ended biology is harder because branches can take weeks and the discarded alternatives may never be run. Some exploration therefore has to be bought. Where two branches are plausible and the stakes justify the cost, a lab should sometimes run the runner-up. Otherwise the record captures what today’s scientists usually chose and stays silent on what they systematically overlooked. A funder could ring-fence a small fraction of a grant for the branch not taken, provided that the decision record and the outcome are both deposited. That costs money, but so does having every lab rediscover the same abandoned path. Test whether taste transfers When it comes time to evaluate if our new AI system exhibits taste, the comparison should run across laboratories and fields. At selected decision points in a live research campaign, we should freeze the six fields: the evidence, the candidates, expected results, confidence, costs and the choice made. Experts then rank the options before the outcomes are known, and those outcomes are checked independently later. We could give models one of two diets - papers alone, or papers plus decision histories - and ask them to rank the next experiment on unfamiliar projects. Then, we score information gained per dollar and week, calibration, and how quickly weak branches are abandoned. If histories improve choices only inside the lab that produced them, they amount to useful organizational memory. If they improve choices on unfamiliar problems elsewhere, Alasdair’s group will have captured something science has never managed to write down: a transferable record of taste. Until that happens, a scientific search history is a promising record, not yet a training set.
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