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State officials, lawmakers press for delay on WakeMed/Atrium deal
After initial media reports detailed the proposed combination of the Raleigh- and Charlotte-based systems, Wake County commissioners may move to slow down decision-making.
Curing U.S. Health Care, Part II
On March 23, 2010 President Barack Obama signed the Patient Protection and Affordable Care Act — usually referred to either as the Affordable Care Act or as Obamacare — into law. Joe Biden, then the vice president, could be overheard whispering “This is a big fucking deal.” And it was. The ACA, which went into full effect in 2014, created a system of subsidies and regulations designed to make health insurance available to many Americans who had previously been left out. It worked: In 2010 there were 47 million uninsured people in America, but by 2016 this number had dropped to 27 million. This still fell short of the universal health insurance that every other advanced nation has, but it was real progress. In 2017, during his first term, Donald Trump tried to destroy the ACA, replacing it with the American Health Care Act — legislation that would have eliminated most of the provisions that expanded health insurance under Obama. At the time the Congressional Budget Office projected that the G.O.P.’s replacement bill would nearly double the number of Americans without health insurance, increasing the total uninsured population by 23 million and undoing all of the progress achieved under the ACA. However, the attack on Obamacare failed by one vote in the Senate, and the ensuing public backlash against the G.O.P. delivered a large victory in the 2018 midterms to the Democrats. After these developments many observers assumed that the ACA had become a more or less permanent feature of American life. Such assessments, however, failed to take into account the deep hostility of the U.S. right toward policies that expand access to healthcare. As we’ll see, this hostility goes back generations. And the second Trump administration has taken actions that the CBO projects will add 16 million people to the rolls of the uninsured by 2034. How did we get here? And now what? Today’s primer will analyze the political economy of U.S. healthcare since the 1940s and the combination of danger and opportunity created by the current crisis. Beyond the paywall I will discuss the following: US health care on the eve of Trump II 80 years of US health politics The Obamacare story The new assault on healthcare
Charlotte-based Atrium Health targets WakeMed in proposed combination
Atrium's proposed deal with WakeMed would extend the reach of the state's largest hospital system and raise new competition concerns.
Spring Health and Alma Complete Combination, Creating the First Lifelong Mental Health Platform
/PRNewswire/ -- Spring Health, a global mental health company built on one AI-native platform, today announced the successful closing of its acquisition of...
White & Case advises Pale Fire Capital on business combination of indoor cycling platform ROUVY with Zwift
Global law firm White & Case LLP advised Pale Fire Capital, a prominent Czech-based investment form, and founders including Petr Samek, on the disposal of ROUVY, a leading indoor cycling and virtual training platform built on real-world routes, to California-based private company and leading
AI could help human scientists pick promising research topics
Large language models flag up novel combinations of concepts in materials science
Personnel note: Dan Boyle joins Mercury Public Affairs
'Dan brings a unique combination of strategic instinct and real-world experience at the highest levels of government.'
7 Supplements You Shouldn't Take Together, According to Doctors
Certain vitamins and minerals don't always mix. Doctors reveal which supplement combinations to avoid and how to take them properly.
Finland’s Kone to buy German rival TK Elevator in blockbuster $34.4 billion deal
The combination would create the world’s largest elevator maker and marks one of Europe's biggest takeovers in recent years.
AMC Entertainment (AMC) Expected to Beat Earnings Estimates: Should You Buy?
AMC Entertainment (AMC) possesses the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.
Political appointments surging, career SES workforce shrinking under Trump 2.0
The federal government has reached its highest level of political appointments in decades, while also undergoing a significant loss of career senior leadership — a combination that one organization warns will lead to poor outcomes across agencies.
Overnight Science Digest: Rethinking thinking by examining animal and AI intelligences
This week’s science news theme—the convoluted relationships between humans and non-human intelligences—arose from an unexpected combination of two dichotomous groups, wildlife and AI. I’ve added in a…
The Planet Needs Prosperous Forests. These Scientists Are Planting More Than 33,000 Trees to Find the Perfect Blend of Species
Forests provide myriad benefits, including timber, wildlife attraction, local cooling and climate resilience. At the Smithsonian Environmental Research Center, ecologists are testing which tree combinations might create flourishing woodlands
The Planet Needs Prosperous Forests. These Scientists Are Planting More Than 33,000 Trees to Find the Perfect Species Blends
Forests provide myriad benefits, including timber, wildlife attraction, local cooling and climate resilience. At the Smithsonian Environmental Research Center, ecologists are testing which tree combinations might create flourishing woodlands
Yankees news: Cam Schlittler’s apprenticeship under Gerrit Cole
Learning from the best; breaking down Cam’s fastball combinations; Rosario adds rise; Boone’s lineup dilemmas
Gran Turismo 7 adds 10 new engine swaps
April 2026’s Update 1.69 has added more engine swap combinations, including a 10 million+ McLaren conversion.
'Catastrophic' | Ohio mental health providers sound alarm over CareSource Medicaid payment clawbacks
CareSource said such adjustments are standard when payment issues are discovered. But many behavioral health providers say the combination of rate cuts and retroactive clawbacks is unprecedented.
Advancing epidemic and pandemic preparedness through research readiness: SEAR Unity Studies Network Sites chart the way forward in 2026
On 25 March 2026, WHO Regional Office for the South‑East Asia Region (SEARO) convened the first meeting of the SEAR Chapter of the Unity Studies Network Meeting in 2026 to take stock of progress and plan next steps for strengthening epidemic and pandemic preparedness across the Region. The meeting focused on reviewing the ongoing adaptation of selected, standard Unity Study methodologies, sharing field implementation experiences from 2025, and identifying key priorities to guide collaborative work in 2026.Held virtually, the meeting brought together representatives from six Unity Studies network sites across five countries (Bangladesh, India, Nepal, Sri Lanka, and Thailand) as well as participants from all three levels of WHO.The meeting took place against the backdrop of ongoing regional efforts in South‑East Asia to strengthen early investigations and studies for epidemic and pandemic preparedness, with a focus on pandemic influenza and other emerging respiratory pathogens with epidemic and pandemic potential. In this context, and as part of preparedness for the rapid generation of evidence, the WHO Health Emergencies Programme in SEAR (WHE/SEAR) encourages Unity Studies sites to adapt prioritized, standardized Unity Study protocols to their national contexts. This approach supports the generation of timely and reliable evidence to inform public health decision‑making during epidemics and pandemics.These efforts are supported through a combination of experience sharing, participation in the global Unity Studies network webinars, capacity‑building of the national public health workforce, and regional collaboration that promotes inter‑country, inter‑agency, and inter‑ministerial action. In parallel, sites are encouraged to explore diversified funding sources to help sustain research preparedness over the long term.Discussions highlighted the importance of WHO’s catalytic financial support through the Pandemic Influenza Preparedness (PIP) Partnership Contributions (PIP‑PC). When combined with national and institutional resources, this support enables countries and sites to maintain continuity of activities at a core level and remain prepared to respond rapidly and effectively to future epidemics and pandemics.Regional and Global Updates: Opening the session, Dr Pushpa Ranjan Wijesinghe, Programme Area Manager, Pandemic and Epidemic Management (PEM) Unit, WHO Health Emergencies Programme, highlighted the progress made in operationalizing the Unity Studies Network across the Region and acknowledged the collaborative efforts of WHO at all three levels, together with country unity studies sites. He emphasized the availability of limited but catalytic funding through the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PIP‑PC) workplan at SEARO to sustain network activities in 2026, while encouraging sites to leverage additional funding sources to expand implementation.Representing SEARO, Dr Ashok Basnet, consultant, Pandemic Influenza Preparedness reported that, at the regional level, the Unity Studies Network currently includes six sites across five countries: Bangladesh, India, Nepal, Sri Lanka, and Thailand. He noted that in 2025, catalytic funding supported protocol adaptation, training, and pilot implementation. In addition, a regional Unity Studies symposium held during the Global Public Health Summit in Sri Lanka strengthened and advocated collaboration between the Unity Studies site, national decision‑making forum, relevant technical units of the ministry of health, WHO and other partners.The symposium also highlighted the role of early investigations and studies as a key component of a multi‑source surveillance system needed at country level to generate a broad range of evidence. It underscored the critical role of country Unity Studies sites and similar research entities in generating evidence to support public health decision‑making during epidemics and pandemics.Participants of the WHO GISRS Unity Studies Sites Network- SEAR Chapter Meeting 2026 (Photo credit- PEM/WHE/SEARO). SEARO also updated participants on ongoing efforts to develop a regional Unity Studies webpage and to promote participation in global knowledge‑sharing platforms, including webinars and the WHO Community of Practice. Priorities for 2026 include supporting the implementation of Unity protocols, strengthening collaboration and experience sharing across sites, documenting and publishing findings, integrating Unity Studies activities as a component of multi-source national surveillance systems, and building workforce capacity.Dr Nickle Boddington of the Global Influenza Programme (GIP) at WHO Headquarters, which coordinates the Unity Studies Network globally, provided updates on global Unity Studies activities, noting that the network has expanded to 16 sites worldwide. New and updated protocols, including rapid clinical severity assessment tools and standardized data platforms, are being developed to support implementation. The global Community of Practice has also been launched to facilitate technical exchange, and continued support will be provided to sites for protocol adaptation, ethical approvals, and readiness for early investigation during outbreaks. Updates from Unity Studies sites in SEAR in 2025Unity Studies sites shared progress and experiences in implementing protocols across diverse country contexts. Sites initiated activities in 2025 using catalytic funding from SEARO, complemented by the mobilization of internal national resources. The Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh, reported the adoption and piloting of investigation protocols on non‑seasonal influenza and emerging respiratory diseases during recent avian influenza outbreaks, demonstrating a multi‑source funding approach involving government, WHO and One Health partners.The Hamdard Institute of Medical Sciences and Research (HIMSR), New Delhi, India, highlighted the piloting of household transmission investigation studies, the expansion of the national Unity Studies network, and the contribution of study findings to global evidence through published outputs. The All-India Institute of Medical Sciences (AIIMS), New Delhi, India, shared experiences from large‑scale seroprevalence studies conducted during the COVID‑19 pandemic, recent efforts to strengthen national Unity network sites through training activities, and plans to initiate multi‑centre studies on respiratory viruses.Similarly, Prince of Songkla University, Thailand, highlighted its experience in developing integrated surveillance and diagnostic protocols for multiple respiratory pathogens, enhancing readiness for targeted investigations of emerging threats. The University of Sri Jayewardenepura, Sri Lanka, reported ongoing engagement with the Ministry of Health and exploration of additional funding sources to initiate studies. Meanwhile, the National Public Health Laboratory, Nepal, provided updates on continued coordination with national stakeholders to initiate implementation, despite delays related to the country context.Across sites, shared experiences underscored the importance of protocol adaptation, multisectoral collaboration, and sustainable funding to operationalize Unity Studies and generate evidence for public health action.Discussions and Way ForwardThe meeting reinforced key priorities for 2026, including strengthening unity studies protocol implementation, enhancing collaboration, knowledge sharing, integrating research as a component of national multi-source surveillance systems, and ensuring that generated evidence informs public health decision‑making. Participants also emphasized the importance of documentation, visibility, and leveraging multiple funding sources, and agreed on the following action points.Unity Studies Sites and WHO Country Offices:Advance adoption and implementation of at least one Unity protocol, continuing activities initiated in 2025 with catalytic funding, supplemented with other sources of funding where feasible.Document site-specific experiences, outcomes, and lessons learned; participate in regional and global knowledge-sharing platforms including WHO webinars and the Community of Practice.Work closely with ministries of health to establish unified national platforms for translating generated evidence into national public health decision-making. WHO Country Offices may facilitate technical support and complementary, synergistic funding opportunities where feasible. WHO Regional OfficeCoordinate with WHO Country Offices to support implementation of core unity studies activities by network sites through catalytic funding and provide technical guidance and virtual engagement opportunities throughout 2026.Facilitate the participation of all Unity Studies sites in the regional meeting on Unity Studies implementation in October 2026, to be held back‑to‑back with the Annual SEAR Regional PIP‑PC Meeting; develop and host a SEAR Unity Studies website; and mobilize support from academic institutions within the SEAR Unity Studies Network to support the development of regional manuscripts that showcase Unity Studies activities to scientific audiences and promote knowledge‑sharing.Explore complementary funding opportunities and partnerships to sustain and expand network activities across the Region.WHO HeadquartersProvide global technical guidance, updated protocols, and toolkits to support the implementation of Unity Studies in SEAR.Facilitate engagement of SEAR sites in global webinars, the Community of Practice, and opportunities to showcase their work.Support joint publications, inclusion of SEAR experiences in global outputs, and identification of additional funding and collaborative opportunities to strengthen Unity Studies activities.
Is Six Flags (FUN) Turning Ride Upgrades Into a Test of Its Per-Guest Value Strategy?
Six Flags New England recently held an exclusive press preview for Quantum Accelerator, New England’s first dual-launch straddle coaster, alongside broader upgrades to Crackaxle Canyon and park-wide dining and retail offerings. The combination of a headline coaster and enhanced food, beverage, and pass benefits highlights Six Flags’ focus on deepening guest engagement and extracting more value per visit. We’ll now look at how Quantum Accelerator’s debut and related guest-experience...
Pagham thump out-of-form Guernsey FC 5-0
Guernsey FC's stuttering end to the season continues as they lose 5-0 at Pagham in the Southern Combination Premier Division.
Proposed adult entertainment, seafood venue in Johnstown canceled
Plans for a combination seafood restaurant and adult entertainment business in Johnstown have been called off after city officials raised concerns about a propo
Sustainability At ESMT Berlin: Bees & Business Lessons
ESMT Berlin is a place to find both future business leaders and bees. A strange combination, perhaps, but one that encapsulates sustainability at ESMT. Here, faculty prepare students to become chang...
Scientists discover spice synergy that boosts anti-inflammation 100x
Chronic inflammation often works quietly in the background but can fuel serious diseases like diabetes, heart disease, and cancer. New research reveals that everyday plant compounds—like menthol from mint, cineole from eucalyptus, and capsaicin from chili peppers—can team up inside immune cells to dramatically boost their anti-inflammatory power. While individual compounds showed modest effects, certain combinations amplified results hundreds of times over by activating different cellular pathways at once.
Scientists discover spice synergy that boosts anti-inflammation 100x
Chronic inflammation often works quietly in the background but can fuel serious diseases like diabetes, heart disease, and cancer. New research reveals that everyday plant compounds—like menthol from mint, cineole from eucalyptus, and capsaicin from chili peppers—can team up inside immune cells to dramatically boost their anti-inflammatory power. While individual compounds showed modest effects, certain combinations amplified results hundreds of times over by activating different cellular pathways at once.
MAGA Is Winning Its War Against U.S. Science
Source: NBER With all the other terrible news right now, you may not have noticed that Donald Trump is in the process of killing American science. OK, that’s an exaggeration — but not that much of an exaggeration. The Trump administration’s latest budget proposal calls for a gigantic increase in military spending combined with severe cuts to social programs. But as the chart above shows, it also calls for debilitating reductions in research funding. Furthermore, Trump appointees have already been strangling science by sharply reducing the rate at which research grants are approved. Here, for example, is the number of new grants approved by the National Science Foundation: Source: Nature Large numbers of existing grants have also been frozen or terminated, especially in the study of infectious diseases. Add to this a sharp drop in visas issued to foreign students, who often play a direct role in research and who help support academic departments that do research: Put all of this together, and much U.S. scientific research is set to come to a screeching halt — not a few years from now, but over the course of the next year or two. This new assault on U.S. science is taking place at a time when the role of American science in the world has already been greatly eroded. The chart below, based on research recently reported by the National Bureau of Economic Research, measures national strength in science by the share of publications in highly ranked journals. In the 1990s the United States had more such publications than the rest of the world combined. Since then we’ve dropped into third place — well behind China and slightly below the European Union. And this was before the Trump administration’s attack on science had time to take its full effect. Source Some erosion in U.S. scientific preeminence was inevitable given China’s growing sophistication and wealth. But we’ve also fallen behind Europe, even though everyone says that Europe is lagging economically and technologically. Claims about Europe’s underperformance are, in fact, dubious if one looks hard at the data. But it’s still striking to see America lagging. What’s going on? There are presumably multiple factors behind America’s scientific lag. But even before Trump II the growing hostility of the U.S. right to science surely had some negative effect. And since the rise of MAGA G.O.P. attitudes toward science in general have become overwhelmingly hostile. This is true even for the Republican rank and file: And while I haven’t been able to find good survey data, it’s obvious that the anti-science turn has been even more pronounced — and began earlier — among the Republican political elite. Chris Mooney published The Republican War on Science in 2005, and even then was describing a longstanding trend. Why have Republicans turned so anti-science? Part of the answer is that they believe that scientists don’t support them. And they’re right! A study of who scientists give money to shows that only a small percentage gave money to Republicans even 20 years ago, and that almost none of them donate to Republicans now: Social scientists have always been strongly pro-Democratic, while there used to be a significant number of physical, “hard” scientists supporting the GOP. But these days physicists are almost as uniformly Democratic, or at least non-Republican, as sociologists. Why are there almost no Republican scientists? It’s not a mystery. GOP political orthodoxy includes positions that are at odds with the scientific consensus on multiple issues, ranging from the validity of the theory of evolution, to the reality of climate change, to the efficacy and safety of vaccines. In each case the scientific consensus is solidly grounded in evidence. But even before the rise of MAGA the U.S. right was increasingly hostile to evidence-based policymaking — especially, of course, where the evidence is unfavorable to fossil fuel interests or quack medicine, both financial mainstays of right-wing politics. So scientists don’t support Republicans, and the feeling is mutual. Today’s Republican Party doesn’t like science or scientists. It doesn’t like having its preconceived views challenged by appeals to evidence. It knows that very few scientists are on its side electorally. In general, it sees scientific research as a threat to its grasp on political power. Add in MAGA’s combination of rabid anti-intellectualism and allergy to any hint of criticism, and one has the makings of a drastic anti-science turn in policy. “Ignorance is strength” might was well be an official MAGA motto. And as I said, we aren’t talking about something that will happen over the course of multiple years: The U.S. scientific enterprise is threatened with severe damage, even collapse, over just the next year. There are many reasons to find this prospect horrifying: Think of all the beneficial advances, affecting almost every part of life, that won’t happen because U.S. science — still crucial to the world — has been eviscerated. But think, also, of America’s international standing. Can a nation that has forfeited its role as a leader, or even a contender, in global science, still be a Great Power? No. MUSICAL CODA
Kavita Fischer: I lost $400,000 betting on sports
I lost more than $400,000 gambling. I’m also a psychiatrist who works with individuals struggling with substance use and behavioral That combination...
Rising energy costs squeeze Rochester-area businesses, forcing tough decisions
Owners point to a combination of rising expenses, including utilities, insurance, taxes and the cost of goods as key drivers behind the financial pressure.
Carbon Emissions in a War-Torn World Threaten Brain Health
The combination of global warming and wars may deliver a double whammy to normal brain function.
Scientists just found DNA “supergenes” that speed up evolution
Hidden within fish DNA are powerful genetic twists that may explain one of nature’s biggest mysteries: how new species form so quickly. In Lake Malawi, hundreds of cichlid fish species evolved at lightning speed, and scientists now think “flipped” sections of DNA—called chromosomal inversions—are the secret. These inversions lock together useful gene combinations, creating “supergenes” that help fish rapidly adapt to different environments, from deep waters to sandy shores.
McCormick buys Unilever's food business in deal that values it at nearly $45 billion
McCormick will pay a combination of cash and equity to expand further into condiments and spreads.
Unilever says nears deal to merge Foods unit with McCormick
Unilever said on Tuesday it was in advanced talks with spice maker McCormick about a potential combination of its foods business in a deal that would include an upfront cash component of about $15.7 billion, with the majority of the consideration in McCormick equity.
Your guide to April events and things to do in Memphis
In Memphis, April offers plenty of opportunities for those seeking entertainment or enlightenment or some combination thereof. Here are 8 of them.
UFC Brings Cage-Match Bout to the White House, Home of a President Who Favors Cage-Match Politics
WASHINGTON (AP) — Cage-match fighting is coming to the White House to fete President Donald Trump, a proud proponent of cage-match politics. In the coming weeks, crews will erect a 6-foot wire-mesh fence shaped into an octagon on the lawn, where UFC fighters will use a combination of kickboxing,
A story of carnival, dance and politics
“I saw the power of combining story with dance and fashion and was really intrigued by the dynamics of that combination,” Amy Kimberly, former executive
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Merlin and Inflection Point Acquisition Corp. IV Announce Closing of Business Combination
Merlin's Cessna Caravan Merlin's aircraft flying overhead at the company's Quonset, RI hangar Merlin's Quonset, RI Hangar A C-130J flying overhead at Merlin’s Quonset, RI hangar Transaction provides more than $200M in gross proceeds to accelerate commercialization of AI-powered autonomous aviation Merlin to Begin Trading on March 17th on the NASDAQ Under Ticker Symbol “MRLN” BOSTON, March 16, 2026 (GLOBE NEWSWIRE) -- Merlin, Inc., an aerospace and defense technology company building the operatin
Scientists unlock a powerful new way to turn sunlight into fuel
Scientists have developed a powerful new computational method that could accelerate the search for next-generation materials capable of turning sunlight into useful chemical energy. The work focuses on polyheptazine imides, a promising class of carbon nitride materials that absorb visible light and can drive reactions such as hydrogen production, carbon dioxide conversion, and hydrogen peroxide synthesis. By analyzing how 53 different metal ions influence the structure and electronic behavior of these materials, researchers created a framework that predicts which combinations will perform best.
Controlled Thermal Resources and Plum Acquisition Corp. IV Announce Definitive Business Combination Agreement to Advance U.S. Critical Minerals and Energy
As one of America’s largest and most advanced geothermal power and critical minerals projects, the transaction is expected to enable Controlled Thermal Resources to advance its Hell’s Kitchen Project and commence Stage 1 construction.Transaction values Controlled Thermal Resources at a pro forma enterprise value of approximately $4.7 billion. IMPERIAL, Calif., March 09, 2026 (GLOBE NEWSWIRE) -- Controlled Thermal Resources Holdings Inc. (“CTR” or the “Company”), an emerging leader in U.S. critic
Oura acquires Doublepoint, a startup that specializes in gesture recognition technology
The company believes its next phase of wearable AI will be powered by a combination of voice and gesture.
Pasqal, A Global Leader in Neutral Atom Quantum Computing, to Go Public via Business Combination with Bleichroeder Acquisition Corp II
Pasqal Holding SAS (“Pasqal”), a global leader in neutral atom quantum computing, and Bleichroeder Acquisition Corp. II (“Bleichroeder”), a SPAC led and back...
Homologous recombination deficiency and hemizygosity drive resistance in breast cancer
Nature - Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.
Safe Codes and Combinations - Resident Evil: Requiem Guide
There are a total of 5 locked safes found throughout Grace's sections of Resident Evil Requiem, each of which contain valuable resources. Here's how
Clover Health Investments Q4 Earnings Call Highlights
Clover Health Investments (NASDAQ:CLOV) executives used the company’s fourth-quarter 2025 earnings call to emphasize a combination of profitability and rapid Medicare Advantage membership growth during what they described as a period of elevated utilization across the industry. Chief Executive Offi
A horse's neigh may be unique in the animal kingdom. Now scientists know how they do it
A horse's signature whinny comes from a combination of whistling and singing.
A horse’s neigh may be unique in the animal kingdom. Now scientists know how they do it
A horse's signature whinny comes from a combination of whistling and singing.
Immunotherapy plus chemotherapy before surgery shows promise for pancreatic cancer
While the combination did not produce a clear survival advantage for most patients, a notable subset experienced unusually deep and durable responses.
Advancing AI for science: extracting and fusing cross-disciplinary expert knowledge with data to accelerate alloy discovery
High-entropy alloys are promising advanced materials for demanding applications, but discovering useful compositions is difficult and expensive due to the vast number of possible element combinations. Now, researchers have developed a novel AI-driven framework that integrates experimental data, computational modeling, and cross-disciplinary expert knowledge extracted from scientific literature. By combining these sources in a way that accounts for uncertainty, their approach can make reliable predictions even for poorly studied alloy compositions, outperforming conventional data-driven machine learning methods that rely on training data alone.
BD Completes Combination of Biosciences & Diagnostic Solutions Business with Waters Corporation
FRANKLIN LAKES, N.J., Feb. 9, 2026 /PRNewswire/ -- BD (Becton, Dickinson and Company) (NYSE: BDX) today announced the successful completion of…...
Uncertainty looms large for Minnesota businesses
While it’s too early to draw firm, data-driven conclusions, no one is going out on a limb by saying the combination of turbulence and uncertainty seen in Minnesota right now will exact an economic price on the state.
Line Combinations: Stars vs. Jets
Stars' potent offense clashes with Jets' defensive grit. Key matchups and a crucial goalie duel define this playoff-charged showdown.
Liquid Meta and STREAMSIX Enter into Business Combination Agreement
Toronto, Ontario--(Newsfile Corp. - January 30, 2026) - Liquid Meta Capital Holdings Ltd. (Cboe CA: LIQD) (FSE: N5F) (OTC Pink: LIQQF) ("Liquid Meta") and STREAMSIX Inc., a private entertainment technology company, based in Toronto, Canada, are pleased to announce that, further to the press release issued on June 24, 2025, they have entered into a business combination agreement dated January 12, 2026, with an effective date of January 1, 2026 (the "Definitive Agreement") which outlines the terms
I built marshmallow castles in Google’s new AI world generator
Starting Thursday, Google AI Ultra subscribers in the U.S. can play around with Project Genie, which is powered by a combination of Google’s latest world model Genie 3, its image generation model Nano Banana Pro, and Gemini.
Analysis: Twice within a week, Trump is forced to tone down big second-term power grabs
Even President Donald Trump’s push for total, unchecked power may struggle to overcome the potent combination of political reality and moral outrage.
Goldgroup Announces Business Combination with Gold Resource Corporation to Create a New, Mexican-Focused Precious Metals Producer
Vancouver, British Columbia--(Newsfile Corp. - January 26, 2026) - Goldgroup Mining Inc. (TSXV: GGA) (OTCQX: GGAZF) ("Goldgroup" or the "Company") is pleased to announce that it has entered into a definitive arrangement agreement and plan of merger (the "Arrangement Agreement") with Gold Resource Corporation (NYSE American: GORO) ("GRC"), whereby Goldgroup has agreed to acquire all of the issued and outstanding shares of GRC's common stock (the "Transaction").Transaction DetailsPursuant to the..
Gold Resource Corporation Announces Business Combination With Goldgroup Mining
DENVER, January 26, 2026--Gold Resource Corporation (NYSE American: GORO) (the "Company," "we," "our," or "GRC") is pleased to announce that it has entered into a definitive arrangement agreement and plan of merger (the "Arrangement Agreement") with Goldgroup Mining Inc. (TSX-V: GGA; OTC: GGAZF) ("Goldgroup"), whereby Goldgroup has agreed to acquire all of the issued and outstanding shares of the Company’s common stock (the "Transaction").
Kentucky health officials warn people about health risks while shoveling snow
The combination of colder temperatures and an uptick in physical exertion can put a strain on the heart and can increase the risk of a heart attack.
Pender Growth Fund Portfolio Company, General Fusion, Announces a Proposed Business Combination
VANCOUVER, British Columbia, Jan. 22, 2026 (GLOBE NEWSWIRE) -- (TSXV: PTF): Pender Growth Fund Inc. (the “Company” or “PTF”) is pleased to report that long-time holding General Fusion Inc. (“General Fusion”) has announced that it has entered into a definitive business combination agreement (the “Proposed Business Combination”) with Spring Valley Acquisition Corp. III (“SVAC”). Upon closing, the Proposed Business Combination is expected to result in General Fusion listing on the Nasdaq and tradin
General Fusion to Become First Publicly Traded Pure-Play Fusion Company Through Business Combination with Spring Valley Acquisition Corp. III
General Fusion is advancing patented and proprietary Magnetized Target Fusion (“MTF”) technology designed to scale for cost-efficient power plants within...
Entheon Announces Execution of Business Combination Agreement with Nutravisor
Toronto, Ontario--(Newsfile Corp. - January 19, 2026) - Entheon Biomedical Corp. (CSE: ENBI) (OTCQB: ENTBF) (FSE: 1XU) ("Entheon" or the "Company") is pleased to announce that it has entered into a definitive business combination agreement (the "Business Combination Agreement") with Nutravisor Inc. ("Nutravisor"), dated January 19, 2026, pursuant to which the parties have agreed to complete a business combination involving a "three-cornered" amalgamation of Nutravisor with a wholly-owned...
Rival Roundup, Vol. 78: Get Reading, Bubba!
We’re less than a month away from pitchers and catchers reporting, which means that in about 10 weeks, we’ll have real baseball to cover. Until such time, we’ll be covering something called hypothetical baseball, where the headlines feature player-team combinations that may never come to fruition, proposed storylines that bear absolutely no fruit, and rumors […]
Independence Power Holdings, Inc. Completes Business Combination/Reverse Merger with TriUnity Business Services; Addresses Permian Basin Power Shortfall with Software-Driven Microgrids
MENTONE, Texas, January 12, 2026--Independence Power Holdings (OTC: ITXP) announces its transition to a public-reporting company following a completed business combination.
US capture of Maduro divides Latin America, thrilling Trump's allies and threatening his foes
Through a combination of tariffs, sanctions and military force, he has pressured Latin American leaders to advance his administration's goals of combating drug trafficking, halting immigration, securing strategic natural resources and countering the influence of Russia and China.
A missing flash of light revealed a molecular secret
Scientists have found a way to see ultrafast molecular interactions inside liquids using an extreme laser technique once thought impossible for fluids. When they mixed nearly identical chemicals, one combination behaved strangely—producing less light and erasing a single harmonic signal altogether. Simulations revealed that a subtle molecular “handshake” was interfering with electron motion. The discovery shows that liquids can briefly organize in ways that dramatically change how electrons behave.
Saints used the second-most offensive line combinations this season
An injury-plagued New Orleans Saints offensive line was just as beaten up as it looked. Just one team has used more line combinations this season.
Applied Digital to Spin Out Cloud Business, Proposes Business Combination with EKSO to Launch ChronoScale
Proposed Business Combination with Nasdaq-listed EKSO to Form an Accelerated Focused GPU Platform Purpose Built for Next-Generation AI…...
First Xiaomi 17 Ultra Leica camera reviews, comparisons and hands-on: Tough times for Samsung Galaxy S26 Ultra and others
2026 will not only be a challenge for Samsung. The Vivo X300 Ultra and Oppo Find X9 Ultra will also have to face an extremely dynamic 1-inch sensor and the first optical 200MP zoom camera in a phone, a combination that convinces in early camera tests and comparison shots. Initial hands-on reports also illustrate the advantages of the Leica Leitzphone Special Edition for ambitious photographers.
Public Health Informatics Specialist
📊 DATA MEETS PUBLIC HEALTH! 📊Northern Nevada Public Health is seeking a PUBLIC HEALTH INFORMATICS SPECIALIST to turn data into life-saving insights! 💡 $78,936/yr + excellent benefits & NV PERS retirement! 📍 Reno, NV | Perfect for you if you have: Bachelor’s in computer science/data sciences and 2+ years health informatics experience; OR an equivalent combination of training and experience ✅ Skills in SQL, R, Python, Power BI desired | Ready to start the new year using your tech skills to improve public health outcomes? This role combines cutting-edge data analysis with meaningful community impact! 🚀 You’ll analyze health data, support disease surveillance, and help shape public health decisions that protect our community! 🌟👉 Apply now: https://www.governmentjobs.com/careers/washoecounty ⏰ Application Deadline: January 30! #HealthInformatics #HealthStatistics #DataScience #PublicHealth #WashoeCounty #TechJobs #RenoJobs
Sports brands and AI: A winning combination
Millions of sports fans are being brought ever closer to the live action from their home screens through the power of agentic and generative AI.
Health and Health Care for American Indian or Alaska Native People: Key Issues
Due to a combination of lower coverage rates, additional access barriers, and historical and ongoing discrimination, AIAN people continue to face significant disparities in health and health care.
Factorial and Cartesian Growth Corporation III (Nasdaq: CGCT) Announce Business Combination Agreement to Accelerate Commercialization of Solid-State Battery Technology
Factorial Inc. (“Factorial”), a leader in solid-state battery technology, and Cartesian Growth Corporation III (“Cartesian III”), a special purpose acquisiti...
Combination pills for high blood pressure may simplify treatment, improve long-term health
Statement Highlights: Single-pill medications that combine two or more blood pressure medications could simplify treatment to help more adults with high blood pressure achieve target blood pressure levels faster and maintain blood pressure goals...
Taking Stock of Elevance Health (ELV)’s Valuation After Digital Health Push and Board Refresh
Elevance Health (ELV) just paired a broader rollout of its AI powered Virtual Assistant with the appointment of veteran healthcare deal maker and governance expert Amy Schulman to its board, a combination investors should parse carefully. See our latest analysis for Elevance Health. Those digital health moves and the Schulman appointment are landing against a clear shift in sentiment, with the share price up 14.3 percent over the past month but a three year total shareholder return still...
Rally House Breaks Company Online Sales Record After Electric Sports Weekend
LENEXA, Kan., Dec. 07, 2025 (GLOBE NEWSWIRE) -- Rally House is thrilled to announce that the company has achieved the largest single-day online sales total in its history. Fueled by an extraordinary combination of high-stakes sports moments and early holiday shopping energy, Rally House saw online sales soar more than 50% year-over-year, marking a historic milestone for the brand and showcasing the company’s commitment to customers, fans, and partners. Fans across the country turned to Rally Hou
Massive volcanic eruptions may have actually caused the Black Death | BBC Science Focus Magazine
New research suggests that a combination of volcanic activity, cold summers and famine brought the deadly plague to Europe.
Here’s What the World Health Organization Had to Say About GLP-1s in its First-Ever Guideline on the Drugs
The health agency supports the long-term use of the medications in combination with a healthy diet and exercise, and calls for equitable access to the drugs
Arsenal's 'beautiful' line-up change
Match of the Day pundit Danny Murphy says Arsenal's squad depth is "remarkable" after Brentford struggled to contain the right side of their attack in the 2-0 win on Wednesday: "It's becoming remarkable now how good their squad is because [Jurrien} Timber and [Bukayo] Saka play on the right hand side normally, which is arguably one of the best combinations down the right side in Europe. "Then they bring in [Ben] White and [Noni] Madueke, who looked like they have played together for seasons. It was a beautiful combination.
DevvStream and Southern Energy Renewables Announce Business Combination Targeting Low-Cost Production of Carbon-Negative SAF and Green Methanol
SACRAMENTO, Calif. & NEW ORLEANS, December 03, 2025--DevvStream Corp. (Nasdaq: DEVS) ("DevvStream"), a leading carbon management and environmental-asset monetization firm, and Southern Energy Renewables Inc. ("Southern"), a U.S.-based producer of low-cost fuels made from biomass, with a flagship Louisiana project that plans to utilize regional wood-waste biomass to deliver green methanol and carbon-negative sustainable aviation fuel ("SAF") at scale, today announced that they have entered into a