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Analysis: Emery's side blown away
"Silence," said Emery when asked pre-match about Ollie Watkins' absence from the Villa squad. Goalkeeper Emi Martinez's future also remain uncertain following a failed move to Juventus and the arrival of Japan's Zion Suzuki. It lays bare the task Emery has to replicate last season's success, having also lost Youri Tielemans, Morgan Rogers, Lucas Digne and Ezri Konsa this summer - all core members of the group.
Spalletti: Everybody here wants success
Serie A is finally back for our Men's First Team, who travel to take on Frosinone on Matchday 1 of the 2026/27 campaign. Kick-off is fixed for 18:30 CEST on Sunday, 23 August.Before setting off for La...
3 minutes of sprinting does something 90 minutes of exercise does not
A few minutes of sprinting may reshape the bloodstream far more dramatically than a much longer moderate workout. Six 30-second sprints altered nearly a quarter of the blood proteins measured and more than 200 metabolites, while 90 minutes of moderate cycling produced far smaller immediate changes. Many of the proteins affected by sprinting were also associated with lower risks of obesity, type 2 diabetes, and other metabolic diseases.
NPR gives Weird Al the respect he deserves.
Plenty of incredible artists have stepped behind the Tiny Desk at NPR’s DC headquarters, from Juvenile and T-Pain to Soul Glo, Tyer the Creator, and even the cast of Sesame Street. But Weird Al Yankovic has now joined the illustrious list of performers invited back for multiple sets. [Media: https://youtu.be/o4I-Y8XiBIs]
Multiple Businesses Burglarized During Overnight Crime Spree; Juvenile Arrested
On August 17, 2026, at approximately 5:00 AM, the El Paso County Sheriff’s Office Regional Communications Center received a call for service reporting a burglary in progress at a business in the 6800 block of Space Village Avenue in unincorporated El Paso County. As Patrol deputies responded, dispatchers received additional information indicating the suspect was […]
Three Juveniles Arrested After Burglary, Assault at Cape Coral Business
CAPE CORAL, Fla. — On Sunday, August 16, 2026, just after 5 AM, Cape Coral Police officers responded to a disturbance […]
Scientists Uncovered a Hidden Switch Inside Our Cells That Could Slow—or Even Reverse—Aging
Mitochondria have long been understood as the powerhouse of the cell. Are they also the powerhouse of rejuvenation?
Video: Lucumi’s first meeting with Spalletti and new Juventus teammates
Juventus have released a few videos of their latest summer signing, Jhon Lucumi, showing his first meeting with Luciano Spalletti and his new teammates, as well as his first training session at Contin...
Coppa Italia Live: Follow Sunday’s First Round fixtures and results
Check the line-ups and live scores as they happen in the Coppa Italia First Round, with Frosinone-Juve Stabia (18:00 local time), Genoa-Ascoli (18:30), Hellas Verona-Virtus Entella (20:45) and Lazio-M...
Focused mental healthcare for young people delivers big savings to Canadian healthcare
A youth mental-health program, national in scale, has been shown to save a country’s public health system $4,000 a year per patient. And while it’s at it, the program helps young people overcome or better manage serious behavioral issues.
Aston Villa preparing offer for Juventus’ Jonathan David
Serie A side Juventus are keen on getting rid of Jonathan David this summer and Aston Villa’s move could soon come forth.The striker failed in his first season in Turin and fell out of favour under ...
PPB, PF&R Safely Rescue Juvenile in Mental Health Crisis
The Portland Police Bureau and Portland Fire & Rescue collaborated for more than an hour to safely rescue a juvenile boy experiencing a mental health crisis.
Juventus rejects Arsenal’s advances for their key man
Juventus have insisted that Kenan Yildiz is not for sale this summer after Arsenal approached them about signing the talented attacker during this transfer window.The Gunners are searching for a marqu...
Chartbook 464 The"China squeeze" - the politics of development counterfactuals.
There are three types of China shock discourse. Each has a distinct temporal register. China shock 1.0 was a phrase coined by US academics in the 2010s to retrospectively summarize the impact on particular US labour markets, which they identified through painstaking empirical investigation. China shock 2.0 on everyone’s lips in Europe in the mid 2020s is an alarm raised by trans-Atlantic policy thinkers warning of a coming disaster which they project onto Europe’s ailing car industry. The third type of China shock discourse - commonly known as the “China squeeze” launched most recently by Indian economists Shoumitro Chatterjee and Arvind Subramanian in the pages of Foreign Affairs - mobilizes a different, more speculative temporal register: the counterfactual realm of alternate history. The China squeeze argument asks not what has happened, or what is going to happen, but what might have been. Specifically, what options for economic development might have been open to Global South economies like India or the economies of sub-Saharan Africa, had it not been for China’s spectacular industrialization since the late 1990s and the persistent competitiveness of China’s manufacture in low-skilled segments. Chatterjee and Subramanian’s argument is that whilst China has built a powerful position in electrical machinery and other high-skill manufacturing, which is now delivering China Shock 2.0, it also continues to run a trade surplus in low-skill, labour-intensive manufacturing. This surplus is large and has remained largely unchanged in fifteen years. Indeed, in the 2010s, in trade with low-income countries, China’s surplus rapidly increased. On their reading, this squeezes low-income producers in low-skill sectors in which they “should” be able to compete. Source: “China’s Mercantilist Squeeze on Developing Countries” Shoumitro Chatterjee and Arvind Subramanian. Peterson Institute for International Economics 26-7 May 2026 Chatterjee and Subramanian’s wording is telling: (emphasis mine) The canonical trajectory of economic development in the post-World War II period is for countries to transition from agriculture to manufacturing, first in low-skilled manufacturing and then later on to high-skill manufacturing (Herrendorf, Rogerson, and Valentinyi 2013). At the global level, this implies that high-income countries (HICs) that once specialized in low-skilled activities cede manufacturing export space to poorer countries that come along to occupy that space. In 1965, advanced economies accounted for about 60 percent of global value-added exports in four key low-skilled manufacturing sectors, i.e., apparel, leather, textiles, and footwear. Over time this share declined and began to be occupied first by the East Asian tigers and, beginning in the late 1990s, by China. Today China accounts for about 50 percent of the global market. The question is whether China, with its rising prosperity, is continuing to behave like its richer counterparts and ceding export space to poorer followers or to behave unlike them and continuing to occupy space. In terms of the conceptual maneuvers it performs, of the three China shock discourses, the “China squeeze” argument is by far the most ambitious. After all, it bases its critique of China on a counterfactual imagining of the world. Like any counterfactual argument, to construct this alternative reality it must rely on a heuristic model. To make their argument Chatterjee and Subramanian mobilize two key claims. The first reference point is the actual history of rich-country industrialization, what they refer to as the “canonical path”. The idea is that countries transition from agriculture to light industry and low-skilled manufacturing and from there up the value chain. To make this useful as a standard of comparison and a means to construct a normative standard, they adjust sectoral export shares for two factors: 1. the underlying level of economic development of the exporting country, as measured by national income and 2. the degree to which the sector in question is internationalized. The idea being that for a high income country to have a high export share in low-skill sectors is anomalous and even more so if that particular product is highly internationalized and thus suitable for being “conceded” to lower-income competitors. Where should this process end? Here Chatterjee and Subramanian introduce their second benchmark. Their normative idea of a global development path is one in which, in due course, low-skill manufacturing exports are distributed in proportion to a country’s share in the global labour force. They imagine, in other words, a world of proportional, polycentric global development without much national specialization in low-skill manufacturing. A useful benchmark is that, in labor-intensive manufacturing sectors, a country’s share of world exports should be broadly commensurate with its share of the world’s low-skilled labor endowment. … In the Heckscher-Ohlin model, this would be true if value added per worker and export propensities, i.e., fraction of output that is exported, are the same across countries. It is this pleasant liberal vista of orderly global development, progressing towards a general distribution of low-skilled manufacturing against which they judge reality and conclude that the low-income countries are suffering a “China squeeze”. China is not exiting low-skill sectors fast enough Allowing for its gdp level and the degree of globalization, China’s share of low-skill manufacturing exports is far higher than it “should” be. Relative to population, its low-skill share of exports is far too high. That in turn yields the conclusion that huge numbers of jobs - the authors suggest tens of millions - are being hoarded by China. For the four sectors captured in figure 4, this excess in value-added exports is $110 billion in 2022. For all low-skilled sectors overall captured in appendix figure D.1, excess value-added exports amount to $365 billion. The crowding out of LMIC exports by China is therefore substantial. Both these claims have in common that they are strong structuralisms. The first is that development paths ought to resemble each other. The second is that broadly speaking as far as low-skilled manufacturing is concerned, all countries are alike. If the world currently diverges from the distribution of trade implied by these assumptions, if China is not following the advanced economy path and has huge exports, this must be the result of “policy”, which the authors then put in question as illegitimate or unfair. Thus the naturalistic construction of a canonical path leading to a “level” distribution of low-skilled manufacturing reveals itself to be a polemical tool. From the point of view of China shock polemics, this discourse is no doubt welcome. But as an account of economic history, it must surely be regarded as nothing short of bamboozling. Development paths do not follow a regular, natural sequence. As David Fishman put it aptly, “development is not a queue”. They are always and everywhere, through and through political. Development is not so much a process, as a project. Each such project is more or less well adjusted to its context. As Gerschenkron taught uneven and combined development implies differentiation rather than simple imitation on a single parth. It may be true that Europe and the US exited relatively early from low-skill work. But clearly technology has changed. As C&S themselves point out, China no longer enjoys a low wage environment. Do they really believe that such huge differences can be accounted for either by industrial policy, which as they admit does not operate powerfully in low-skill sectors, or by exchange rate manipulation? What is overwhelmingly dominant in explaining the persistence of “low-skill” manufacturing in China are surely the network effects of complex supply chains. Indeed the label of “low-skill” may miss the point. The degree of globalization which Chatterjee and Subramanian decide to conjure away in their model of the development path - to allow for the fact that Europe and American textiles exporters did not enjoy just-in-time logistics in the 1950s - obscures the point that the networks through which Chinese factories supply the world are themselves key parts of the low-skill industrialization project. China isn’t knocking out 1970s style “cheap”. It has redefined the entire product cycle. C&S’s casual reference to “T-shirts” is telling. In today’s “fast fashion”, there is weight on both terms. Fashion and fast. China’s success in delivering on both at unprecedentedly high speed and at unprecedentedly low cost, isn’t a low-skill operation at all. If we see development trajectories not as the serial repetition of the same, but as distinctive, crafted projects that cumulate in complex agglomerations of skill, technology and labor, then this explains why the assumption that low-skilled manufacturing should follow the distribution of population flies in the face of all experience. As countless cases attest, low-wage, low-income developed economies are not by themselves the makings of a competitive production base. As Leon Liao puts it quite fairly: “International trade has never been allocated according to population. A country’s population gives it no natural claim to an equivalent share of global exports." And the remarkable fact is that Subramanian alone and with co-authors has long been making this point, not to pillory China, as is the case of the tendentious _Foreign Affair_s and Peterson pieces, but to highlight the great counterpart to China’s industrial success, namely India’s relative failure. The much-quoted Foreign Affairs piece showed low-skill export shares only for China, not for India. If you put both countries in the picture as Chaterjee and Subramanian have done on other occasions, the picture looks like this. China is far above the line, but India, almost as large in terms of population, is no less anomalous, just in the opposite direction. As far as global populations are concerned, and the imagining of tens of millions of “squeezed” jobs, it is this Sino-Indian pair that account for a huge share of the action. What this graph reveals is not China’s cheating, but India’s “greatest development failure”, at least this is the argument made Arvind Subramanian, this time in co-authorship with Devesh Kapur, in their major book, A Sixth of Humanity. Independent India’s Development Odyssey which appeared with Oxford University Press earlier this year. In this highly critical work on India’s development, China is repeatedly evoked, not to criticize but as a benchmark against which to illuminate what India’s political economy has not delivered i.e. large-scale formal employment for hundreds of millions of citizens. Kapur and Subramanian leave no doubt, if you want to understand why China, not India was the main driver of manufacturing globalization from the 1980s, don’t look to slots opening up in the division of labour thanks to the liberal mindedness of advanced economies, look to the contrasting political economy of the Maoist PRC and India’s post-independence political economy. As Kapur and Subramian note: The great divergence between China and India did not begin in 1978 with the Deng reforms—it was well underway by then. In one of the great ironies of modern history, the conditions created by Maoism turned out to be a great launching pad for industrial globalization. As the comparison of India and China in 1980 makes clear, to imagine manufacturing would be equally distributed when populations are so differently endowed in terms of educational and nutritional is fanciful. Here is the data from Kapur and Subramanian, data which I explored back at the very beginning of Chartbook. As Kapur and Subramanian insist, the striking fact is that even as India’s growth accelerated from the 1980s, structural change has not. Formal employment in India lags woefully behind. Why? As Kapur and Subramanian note, the path-dependent impact of India’s poor early start was devastating. The list of factors they mention is long and weighty: We argue for a new five-fold explanation applicable at different stages of Indian history: in the initial stages, the legacy of two key pre-1980s policies, the neglect of agriculture and the strangling of the domestic private sector, were critical. The failure of broad-based agricultural growth militated against rural industrialization, which would have been devoted to satisfying local needs that would have necessarily been labour intensive. Then, when the boom came after 1980, the thicket of regulation and broader labour protections that were legislated prematurely in a nascent democracy, underpinned by a deep ideological aversion to private capital in general and big capital specifically, became a barrier to attaining the size that would be necessary to compete globally. Similarly, the reforms after 1991, while wide-ranging, did not quite encompass non-tradeable inputs critical to manufacturing, namely, land, logistics infrastructure and power. A combination of low investment (logistics infrastructure), regulation (land) and the continued monopoly supply by state governments (power), combined with residual socialism, kept costs at 75–100 per cent above efficient supply. These factors were compounded on the supply side by the government, which dominated the formal labour market and established exorbitantly high wages at the lower end of the skill spectrum. This made their employment in the labour-intensive sector by the private sector less attractive. Finally, when the services sector and its exports boomed, wages soared even further via a Dutch Disease effect: one successful tradeable sector killed and cannibalized another less-skilled tradable sector, namely, manufacturing. Thus, scarcity-inducing policies of the planning era, precocious democracy and a Gandhian aversion to size; inefficient, monopolistic supply of critical non-tradable inputs; the behemoth of government; and super-successful skill-intensive services successively undermined India’s unskilled labour employment opportunities. The employment failure seems to have been over-determined. … Less quantifiable but no less important are some of the sociological factors that have undermined manufacturing and factory jobs. Take the impact of the success of the IT sector—located in urban areas with better working conditions, such as air-conditioned offices, good schools for children and attractive entertainment options. It became a more attractive place for engineering and management graduates to flock to. … Consider manufacturing and female employment. Indian society makes it difficult for women to work, reflected in India’s unusually low female labour force participation (elaborated in Chapter XIII). Indian society, in particular the routine harassment of women in public spaces, makes it even more difficult for them to travel long distances to take up work.37 Combined with onerous regulations on creating hostels and dormitories for women—which, in turn, prevents multiple shifts of operation—factories need to be located in areas with a large female labour pool. While firms can take apparel plants to female labour or bring them to the plants by building large-scale dormitories, this raises costs. If there was a case for subsidies to encourage labour-intensive manufacturing, housing subsidies to build dormitories for women workers would be a good place to start. All of this meant, that when opportunities did open up, in part thanks to adjustments in China, India was in no position to take advantage. Here is the account of the 2020s from Kapur and Subramanian. It stands in dizzying contrast to the one-sided, “China squeeze” argument delivered in the Peterson and Foreign Affairs pieces: In 2022, for example, India’s share of global exports in clothing (the canonical labour-intensive sector) was 3.1 per cent compared to 32 per cent for China. This is extremely disappointing because China started vacating export space in this sector after the Global Financial Crisis as its wages started rising; it then vacated further space in the aftermath of geopolitical developments that led investors to seek alternative investment locations. Between its peak and today, China lost about 7.5 percentage points of global export share (worth about $43 billion in 2022); over this period, India’s export share remained stagnant at 3 per cent, while that of Vietnam and Bangladesh rose by 3.5 to 4 percentage points. China’s loss did not translate into any gain for India in terms of low-skill exports and employment. Put differently, when the conditions for dynamism and prosperity were established after 1991, and even more tantalizingly when the global export opportunities opened up, it was as if India was a high-wage economy and only skilled labour could benefit from the dynamism. It had converted its physically abundant unskilled workforce into an economically expensive resource, penalizing its use. It is not my mission here to argue for or against Kapur and Subramanian’s interpretation of India’s development trajectory. The point in this context is simply that the “China squeeze” such as it is can only be understood, in relation to the heavy burden of domestic constraints that Kapur and Subramanian so unsparingly enumerate. I am concentrating here on India because it is the great counterpart to China and the unspoken reference point of the “China squeeze” discourse. But the point is more general. Can anyone with a straight face suggest that the main problems afflicting the development of South Africa or Nigeria, the great centers of mass underemployment in sub-saharan Africa, are cheap competition from China driven by Beijing’s industrial policy and an undervalued RMB? Likewise, is the main problem of the American working-class the threat of Chinese competition or the manifest crisis of social reproduction in the United States itself? The point here, as in the discourse around China shock 2.0 in Europe, is to insist that we should not normalize the world and pathologize China, without actually investigating what is going on in America’s industrial wastelands, the German car industry, or India’s lopsided labour market. One-sided pathologization should be understood for what it is, a polemical gesture. Concepts like China shock and China squeeze are, what Reinhart Koselleck, following Carl Schmitt, would have described as “asymmetrische Kampfbegriffe”, or “asymmetrical counter-concepts” or “asymmetrical combat concepts”. If the function of arguments like the “China squeeze” is to alert elites in the rest of the world of the need to rejuvenate and energize their development projects, so be it. But let us see the resulting discourses as the mobilizing interventions that they are. Interestingly, a significant slice of China’s public sphere - the so-called industrial party - have been obsessed for the last twenty years with precisely these questions of counterfactual economic history. Since the mid 2000s, a massive online discourse developed around an alternative history in which Chinese techno-patriots were asked to imagine how they would proceed if they had the possibility of traveling back in time to transport modern technology into the Ming dynasty (1368-1644) thus averting the “great divergence” of the 18th and 19th centuries. It is a fantasy of course, but also a goad. The point was not directed at Westerners. The alternate history is dramatically nationalist, but few n the West had even heard of it until recently. The adherents of the industrial party are not liberal moralists. They don’t project natural ladders of international development and ask why others don’t cede space. They take the Realpolitik of global economic development for granted. Their pointe was directed against fellow Chinese. The rallying cry of the alternative narrative was this: Now that we are beginning to gain steam and push forward on our national development path, now that we are breaking out of the inferior position assigned to us even in the early years following WTO accession, do not lose yourself in humanistic imaginings about better futures. In the spirit of Deng, they called on China to embrace the hard truth of development. Perhaps one might of the Industrial Party as a cultural trend born out of desire for symbolic revenge against those who had inflicted the century of humiliation. In terms of the various temporalities of the “China shock” - retrospective, prospective and counterfactual - one might think of the Industrial Policy discourse as truly speculative, conjuring up the China shock that never was. Or perhaps one might better think of it as imagining a world in which a powerful China was no shock at all, but simply a defining fact of modern history. I love putting out Chartbook. I am particularly pleased that it goes out for free to thousands of subscribers around the world. But, writing this newsletter takes a lot of work. If you are enjoying it and would like to support the project, sign up for one of the subscription options here. It is the equivalent of a fancy cup of coffee per month! Subscribe
For the first time ever EA SPORTS will broadcast two Juventus friendlies
The partnership between Juventus and EA SPORTS continues to evolve with new ways to enjoy the content, and for the first time, fans will be able to watch two of Juventus’ pre-season fixtures live ...
Multiple patients arrested after chaos erupts at Chandler juvenile health center
Police used pepper balls and made multiple arrests after juveniles sparked back-to-back disturbances at a Chandler behavioral health facility.
Gossip: Zirkzee wanted by Juventus
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Bianconeri beat Standard Liege with Miretti strike
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Lawyers for low-income metro Detroiters to strike over health care
The lawyers set to strike handle 50% of cases for defendents who can't afford an attorney in Wayne County.
Gossip: West Ham keen on Foxes defensive duo
West Ham are considering a move for Leicester City's English defender Ben Nelson with the Hammers hoping they can secure the 22-year-old for a cut-price fee following the Foxes relegation to League One. Football Insider) West Ham are also interested in Leicester City centre-back Harry Souttar, though they face competition from Wrexham for the 27-year-old Australia international. Daily Record) West Ham's French centre-back Jean-Clair Todibo, 26, is wanted by Juventus.
6 teens arrested after employee attacked inside Rochester business
Six people, including five juveniles, were arrested after a fight inside a business on East Main Street on Tuesday morning, according to the Rochester Police Department.
Pellegrini’s contract renewal, agreement worth €3 million
Lorenzo Pellegrini is waiting to renew his contract with Roma. The Giallorossi midfielder is in the capital and rejected Juventus’s offer to convince him to join Spalletti’s project, as they did w...
Rejuvenation science: Rewinding biological clock works for mice, not yet for humans
THE QUEST TO LIVE LONGER, fuller lives has captivated humanity for millennia. In lab mice, scientists have spent about a century studying the cellular
Jail should not be the only option for kids in mental-health crisis
States need to reverse the decline of residential psychiatric treatment options for youth, before juvenile detention becomes the default alternative.
Paolo Banchero Q&A: Magic star rejuvenated with new coaching staff
Today’s Papers – It’s over for Ronaldo, Juventus move for Pellegrino
La Gazzetta dello SportWorld Cup kickedThe scandal of the suspended red cardControversy over the pardon for the American. Trump: ‘Yes, I’ve asked Infantino.’ UEFA: ‘That’s how you lose credi...
Liverpool must pay €50m to sign midfield transfer target
Khephren Thuram Transfer Price Set as Liverpool Face Juventus Midfield DecisionLiverpool have been given the sort of transfer message that leaves little room for theatre. Juventus have named their num...
Liverpool interested in £43m-rated Khephren Thuram
Liverpool are interested in Juventus midfielder Khephren Thuram, according to Tuttomercatoweb.The Reds’ midfield was a major area of concern last season, with Alexis Mac Allister and Ryan Gravenberc...
Cranston business damaged after car crashes into it
CRANSTON, R.I. (WPRI) — A business in Cranston was significantly damaged after a car crashed into it late Friday night. According to police, just after 11 p.m. a juvenile boy was driving alon…
The secret to healthy aging may be hidden in your blood
Some people live past 100 with remarkable health, and researchers may have uncovered one reason why. A new study found that centenarians have a unique chemical "fingerprint" in their blood that sets them apart from normal aging, including unusual patterns of bile acids and steroids linked to longer survival.
The secret to healthy aging may be hidden in your blood
Some people live past 100 with remarkable health, and researchers may have uncovered one reason why. A new study found that centenarians have a unique chemical "fingerprint" in their blood that sets them apart from normal aging, including unusual patterns of bile acids and steroids linked to longer survival.
The Rolling Stones: Foreign Tongues review – stomping blues and anti-Musk politics make this another late triumph
Continuing the rejuvenated sound of 2023’s Hackney Diamonds, there’s touching vulnerability from Keith Richards while Jagger confronts war and autocracy
Malik Willis Has 6 Career Starts and CBS Sports Just Ranked Him Among the NFL's Most Intriguing QBs
The NFL is a pass-heavy league, and teams rely on aerial attacks and high-scoring offenses not just to win games, but to contend for a Super Bowl championship. "After rejuvenating his career in Green Bay, Willis will get his first legitimate chance to be an NFL starting quarterback," DeArdo wrote. "It'll be a challenge, though, as Willis is joining a Dolphins team that is starting anew."
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Juventus hold exploratory talks for Soule’s return
Matias Soulé is among the candidates to leave Roma in the coming days and be sacrificed on the altar of capital gains. The Argentine winger isn’t pushing to leave; on the contrary, he’s stalling....
Rejuvenating politics and delivering on promises of equality and participation: milestone event in Strasbourg
Young people are shaping the New Democratic Pact for Europe
Open 2026 World Cup Watch Thread: Day 11
No Juventus players on the schedule, but there are some teams in desperate need of points.
Tulsa County launches mental health crisis bed partnership for youth in custody
Tulsa County leaders said a new partnership aimed at addressing the mental health needs of youth in custody could change the way Oklahoma responds to children i
Fells Point businesses raise concern over juveniles, open containers, illegal liquor sales
Rejuvenate Bio and Merck Animal Health Join Forces on Novel Animal Health Gene Therapy Programme
Rejuvenate Bio and Merck Animal Health Join Forces on Novel Animal Health Gene Therapy Programme
Scientists found the strength training sweet spot for a longer life
Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.
Scientists found the strength training sweet spot for a longer life
Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.
Gossip: Brighton reject second Spurs bid for Van Hecke
Brighton have rejected a second bid from Tottenham for Netherlands centre-back Jan Paul van Hecke, 25. Talksport) Meanwhile, Spurs' Guglielmo Vicario has emerged as the frontrunner as Juventus look to sign a new goalkeeper. (Gazzetta dello Sport - in Italian)
Report: Goretzka reconsidering Juventus move due to Milan crisis
Leon Goretzka is reportedly reconsidering his transfer destination, with Juventus emerging as a serious option after the organizational collapse at AC Milan stalled what had appeared to be an imminent...
Upstate county's lawmakers push bill holding parents accountable
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JUVENTUS AND WWE ANNOUNCE STRATEGIC PARTNERSHIP TO CONNECT SPORT, ENTERTAINMENT AND GLOBAL FAN CULTURE
Juventus and WWE today announced a new strategic partnership designed to develop original experiences, content and activations that bring together...
Chelsea consider €30m deal for Juventus defender Cambiaso
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Juventus eyeing Tottenham goalkeeper Guglielmo Vicario
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Barcelona not interested in Juventus fullback despite recent reports
Barcelona are in the market for multiple players this summer, with the likes of Julian Alvarez being closely linked with a move to the Camp Nou.However, apart from signing a top striker, Barcelona are...
Nottingham Forest Eyeing Move for €45m Juventus Forward
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Chelsea linked to Juventus defender amid potential Cucurella exit
With rumors swirling about Marc Cucurella wanting out of Chelsea, the team has been looking for his replacement, and it appears they have a top candidate.
Healing first: How Mendota Juvenile Treatment Center is succeeding
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Liverpool star keen on move to Serie A giants
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Heysel Memorial Day
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Early 2000s star brings first solo album in 12 years to Oakland
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Three juveniles arrested for armed robbery after threatening business with airsoft gun
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📹 Player triggers anti-racism protocol against own fan
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Injured Juventus star Yildiz ruled out of Turin Derby
Juventus will be forced to cope without their star Kenan Yildiz for the final game of the season against Torino as the Turkish talent has sustained a calf injury.Juventus attacker Yildiz will miss the...
Today’s Papers – Juve out, Inter taunt Milan
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Juventus lost to Fiorentina 2-0 on Sunday and saw their Champions League qualification hopes go tumbling down the mountain as a result.
Rebooting stem cells builds aged muscles and assists injury recovery
Muscle stem cells, which are crucial for building new muscle, don’t work as well as we get older, but giving them an artificial boost could rejuvenate them
Louisiana Republicans' plan to gut New Orleans’ court system nears Gov. Jeff Landry's desk
In its current form, Senate Bill 217 by Sen. Jay Morris, a West Monroe Republican, cuts the number of criminal court judges from 12 to 9 and civil court judges from 14 to 13. It also halves both the number of juvenile court judges and traffic judges, from four to two.
Secret Service shoots man who fired at agents near Washington Monument
The US Secret Service says its officers shot an armed man Monday afternoon near the Washington Monument after he fired at agents and wounded a juvenile bystander.
Alisson Becker transfer news: Juventus make Liverpool goalkeeper a top target this summer
Milan vs. Juventus game draws criticism across Italy
The 0-0 draw between Milan and Juventus on April 26, 2026, has drawn criticism in Italy for the defensive playing styles of both teams, resulting in an inevitable stalemate.Milan’s recent meeting wi...
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Cellular Rejuvenation Has the Potential to Reverse Aging
A new therapy has the potential to cure hundreds of diseases — and even reverse aging.
Warming waters are supercharging an invasive salmon predator in Alaska
As Alaska’s rivers warm, invasive northern pike are becoming noticeably more voracious. Scientists discovered that pike of all ages are eating more fish, with young pike increasing consumption by over 60%. Warmer water speeds up their metabolism, pushing them to hunt more. This growing appetite could spell trouble for struggling salmon populations.
Warren County teen accused of stealing $25,000 in merchandise from golf business
A 17-year-old in Warren County remains in juvenile detention after being accused of breaking into a Lebanon driving range four times and stealing tens of thousands of dollars in merchandise.
Sen. Mark Warner's daughter dies of juvenile diabetes and other health issues at 36
The death of Madison Warner, 36, rendered lawmaker and wife "heartbroken beyond words."
U.S. Sen. Mark Warner’s daughter dies after decades-long health battle
The 36-year-old daughter of U.S. Senator Mark Warner has died after experiencing a decades-long battle with juvenile diabetes, the Warner family said Monday.
AC Milan and Juventus close in on Champions League qualification
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Centipede consumption boosts growth and gut health in endangered crocodile lizards
A new study in Biological Diversity reveals that centipede consumption enhances growth and gut microbiome homeostasis in juvenile crocodile lizards by enriching beneficial fermentative bacteria and elevating short chain fatty acid production, underlining the critical role of dietary diversity in the conservation of endangered reptiles.
Juventus vs Bologna – Predicted lineup and team news
Juventus will aim to strengthen their hold on a top-four spot when they face Bologna at the Allianz Stadium on Sunday in Serie A.The Turin side has an impressive record in this fixture, going unbeaten...
Juventus look at Lucumi amid competition for first choice Senesi
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🚨 Official: Juventus tie down one of their key men!
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Today’s Papers – Allegri’s frosty relationship with Milan, Yildiz’s knee problems
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Sport, Culture and Brand: Juventus Brought Black&White to Chengdu
Following the success of the Youth Carnival event in Shanghai, Juventus returned to China, bringing its colours to Chengdu from 10 to 12 April 2026. The three-day initiative was dedicated to sport, cu...
Today’s Papers: Two Italy duels, Inter strength, Juventus stars
La Gazzetta dello SportDuels of Italy Malago-Abete for the FIGCAzzurri CT: Allegri battles ConteSerie A in agreement (19 of 20) in favor of the former CONI President. The number one of the amateur le...
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Today’s Papers – Shocking Milan, Juventus celebrate
La Gazzetta dello SportInter in Como for the Scudetto. Pio must do a LautaroNapoli in Parma with the comeback dream. Conte: ‘Let’s put pressure.’Great LadyWins in Bergamo and narrows the Champio...
Juventus predicted lineup and team news vs Atalanta
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Scientists say we’ve been treating Alzheimer’s all wrong
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OPINION: Social media tax would hurt Nebraska’s small businesses and communities
I understand lawmakers’ social media concerns, and I share their desire for juvenile mental health. But those issues should be funded directly.
Citizen science trail camera project studies winter tick impacts on moose in northeast Minnesota
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Serie A winger linked with Liverpool as Salah replacement
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April’s Trading Post Positively Sprouts with Garden Delights
April’s Trading post arrives in full bloom, heralding in the rejuvenation of sun-dappled days and tending the garden. Take part in a variety of activities to earn this month’s reward— get the Ensemble: Forest Dweller's Butterfly Attire transmog set.
Stroke triggers a hidden brain change that looks like rejuvenation
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
Skin therapy business opening with celebration next month in the Poconos
The new location will offer customized skin rejuvenation treatments, including advanced exfoliation, LED light therapy, and modern facial technologies.
A “ghost” great white shark just reignited a Mediterranean mystery
A rare encounter with a juvenile great white shark caught by fishermen in April 2023 has reignited scientific interest in the mysterious population of these apex predators in the Mediterranean Sea. By reviewing records spanning more than 160 years, researchers found that great whites still appear sporadically in Spanish Mediterranean waters, suggesting the population—though elusive and declining—has not vanished. The discovery of a young shark raises an intriguing possibility: these legendary predators may still be reproducing in the region.
Cartesian Therapeutics Reports Full Year 2025 Financial Results and Provides Business Update
Enrollment continues to progress in Phase 3 AURORA trial of Descartes-08 in myasthenia gravis Phase 2 TRITON trial of Descartes-08 in dermatomyositis and antisynthetase syndrome, expected to initiate in 1H26 Phase 1/2 HELIOS pediatric trial of Descartes-08 in juvenile dermatomyositis actively enrolling Approximately $126.9 million cash, cash equivalents and restricted cash as of December 31, 2025, expected to support planned operations into mid-2027, including completion of ongoing Phase 3 AUROR