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Scientists discover hidden driver of aging — Simple supplement reversed brain decline
A newly identified brain protein may play a major role in how the body ages. Researchers discovered that declining levels of Menin in the hypothalamus triggered inflammation, memory problems, bone loss, and other aging-related changes in mice. Restoring Menin reversed several of these effects, while a simple amino acid supplement called D-serine boosted cognition. The discovery opens a surprising new path for fighting age-related decline.
One mystery of the Great Pyramid’s longevity has finally been solved
Differences in how the pyramid and surrounding soil vibrate, along with design choices, have protected the structure from earthquakes.
‘Morbid’ doesn’t want you to fall for antiaging hype
Scientist Saul Justine Newman debunks high-profile longevity research and antiaging “medicine” in a new book.
At least 80% responsibility for ill health in old age down to individual, says study
UK report argues people have greater control over longevity than widely understood, but others say claim is simplistic
SimonMed hopes to drum up whole-body MRI business
The Tucson, Arizona-based radiology practice announced it will offer 20% discounts on its longevity scans to the military, veterans and first responders.
John Cena plans to lift weights in his 80s: longevity lessons from WWE
WWE icon John Cena said he's training for longevity with 3 tips he picked up in his pro wrestling career. He wants to stay strong for years to come.
Big lessons the US can learn from a country with one of the fastest-growing lifespans
There is a lot the United States can learn about health and longevity from South Korea.
The Woman Selling Longevity to Women Left Out of the Boys Club
Influencer Kayla Barnes-Lentz has built a loyal following arguing that wellness protocols based on male-dominated science don’t cut it for half the population.
Can having a dog boost your longevity? Here’s what science says.
There is some research that suggests furry friends improve the health of their humans.
Can having a dog boost your longevity? Here’s what science says.
There is some research that suggests furry friends improve the health of their humans.
Marketers say NAD+ pills and infusions can boost longevity. What's the evidence?
Wellness and longevity influencers are pushing a compound called NAD+. There's scientific interest in its potential, but researchers say the marketing claims have gotten ahead of the science.
Why the Wellness Industry Is Betting Big on Longevity Science: Expert View by Spherical Insights
Wellness market is projected to grow from approximately USD 5.4 trillion in 2024 to nearly USD 10.73 trillion by 2035, registering a CAGR of around 6.44% during 2025–2035.
Lessons From America’s Oldest Distillery
The Laird family has owned its distillery operation almost continuously for over three centuries. Its longevity offers valuable lessons.
Scientists successfully transfer longevity gene and extend lifespan
Scientists at the University of Rochester pulled off a remarkable experiment: they transferred a longevity-related gene from the famously long-lived naked mole rat into mice, and the mice ended up healthier and lived longer. The special gene boosts production of a substance called high molecular weight hyaluronic acid, which appears to protect against cancer, reduce inflammation, and support healthier aging. The modified mice showed stronger resistance to tumors, healthier guts, and lower levels of age-related inflammation.
One Critical Factor Predicts Longevity Better Than Diet or Exercise, Study Finds
It's vital for almost every aspect of our well-being.
Benefits of walking for health and longevity explored by 'Walk' authors
'Fox & Friends' co-host Steve Doocy joins Dr. Courtney Conley and Dr. Milica McDowell to discuss the myriad benefits of walking for health and longevity. They highlight 'Vitamin W' and 'movement snacks' to improve overall wellness.
9 Supplements Doctors Recommend Most to Support Healthy Aging
Many supplements promise to help you live longer, but aren't actually backed by science. Here are the ones doctors actually recommend for longevity.
David Attenborough’s 4 Longevity Habits At Age 100 For A Healthy Life
The acclaimed nature documentary filmmaker has adopted lifestyle habits that can boost health and longevity.
Sir David Attenborough Is 100 Years Old Today! This Could Be The Secret of His Longevity.
Happy birthday, sir!
Trump's pick for science director: a Silicon Valley investor with no science background
Jim O'Neill, a longevity enthusiast and vaccine skeptic, is Trump's pick to head the National Science Foundation
Brain health supplements are booming. Here’s what one longevity expert takes.
Only one has been shown in clinical trials to slow cognitive aging, by about two years. This is what the science says about which supplements work.
New water battery could last until the 24th century — and it can be safely discarded in the environment
With no toxic elements to dispose of, the new aqueous battery design could dramatically improve the safety and longevity of battery energy-storage systems.
Who’s selling longevity? Biohackers are buying.
Several companies are currently positioning themselves at the crossroads of metabolic health and longevity
The Longevity Secrets Helping Athletes Blow Past the Limits of Age
With cutting-edge sports medicine and sci-fi gadgetry, more and more athletes are figuring out how to extend their careers.
The Longevity Secrets Helping Athletes Blow Past the Limits of Age
With cutting-edge sports medicine and sci-fi gadgetry, more and more athletes are figuring out how to extend their careers.
Bryan Johnson tweet draws attention to vaginal microbiome. What is that?
Bryan Johnson tweeted his wife's vaginal microbiome test results. We spoke to OBGYNs and longevity advocates about what that is and if you should do it too.
Thymus renaissance poised to boost health and longevity
Nature Biotechnology - Evidence linking thymic function with health and longevity is piling up, and a cluster of biotechnology companies is trying to regenerate the thymus directly or recapitulate...
Long-deferred projects move forward as Chicagoland communities build for the future
Communities throughout Chicago are modernizing public facilities as part of a broader construction effort to build for function and longevity.
The body’s most mysterious organ may play a key role in longevity and cancer
A raft of research is recasting the thymus from a bit player to a potent regulator of aging and immune health.
The expert on 'super aging' breaks down the science — and grift
From peptides and protein to sleep hygiene and vaccines, what actually helps you age well? Physician Eric Topol breaks down the science — and the myths — of longevity and anti-aging.
The expert on 'super aging' breaks down the science — and grift
From peptides and protein to sleep hygiene and vaccines, what actually helps you age well? Physician Eric Topol breaks down the science — and the myths — of longevity and anti-aging.
A Scientist Says Humans Will Stop Aging by 2029, Here's the Technology That Could Make It Real
A futurist l predicts humanity could reach "longevity escape velocity", the point where life expectancy grows faster than we age. But is it realistic?
3 aging mistakes top longevity doctors and scientists say to avoid
It's hard to tell which longevity trends actually work. Doctors and scientists shared what they wish people would stop doing in the hope of optimizing their health.
A Scientist Says Humans Will Go Backwards in Time Within Just 3 Years
Computer scientist and futurist Ray Kurzweil believes humanity will achieve “longevity escape velocity” in just three years.
10 simple longevity hacks doctors and scientists use to stay healthy
Top longevity doctors, scientists, and investors share the simple, evidence-backed habits they use to stay healthy — from sleep and diet to exercise.
10 simple longevity hacks doctors and scientists use to stay healthy
Top longevity doctors, scientists, and investors share the simple, evidence-backed habits they use to stay healthy — from sleep and diet to exercise.
This ‘longevity drug’ may weaken gains from exercise
Researchers anticipated rapamycin would enhance the effects of working out, while also initiating health improvements of its own, but the results surprised them.
Your Mouth Could Be Aging You Faster—The Hidden Health Risk
Your mouth may reveal more than your smile—experts link gum health to heart disease, inflammation, and aging. Here’s why oral care is key to longevity.
Can Spending More Improve Your Health and Prolong Your Life?
The desire to live longer and healthier lives has spawned a growth in services and supplements. So what works best?
Health insurance and end-of-life healthcare expenditures: evidence from Chinese Longitudinal Healthy Longevity Survey
npj Health Systems - Health insurance and end-of-life healthcare expenditures: evidence from Chinese Longitudinal Healthy Longevity Survey
She's 35 and obsessed with living longer. It might be working.
It's the Wild West for women's health and longevity, and Kayla Barnes-Lentz is taking the reins.
Cedars-Sinai Event Explores Ethics of Longevity Science
Cedars-Sinai experts and prominent scholars of religion, Jewish law and ethics are coming together on May 3 for a free public discussion focusing on the ethical, moral and theological questions that can result from medical breakthroughs.
Geneva College of Longevity Science Launches the World’s First PhD in Longevity Sciences
GENEVA and CONSTANȚA, Romania, April 24, 2026 (GLOBE NEWSWIRE) -- The Geneva College of Longevity Science (GCLS) today
Why recreational sports are recommended for health and longevity
Recreational sports are recommended because of the variety of movements they offer.
Column | Just 2 minutes a day of this type of exercise may help you live longer
Getting older doesn’t have to mean slowing down. In fact, turning up the intensity, even very briefly, can transform long-term health and improve longevity.
Kara Swisher examines the science, tech and business of living longer in new CNN docuseries
Kara Swisher begins her new CNN series on longevity and health in a cemetery, reflecting on her father's death. The series, “Kara Swisher Wants to Live Forever,” explores how health
An 80-year-old woman has an elite VO2 max thanks to simple habits
Linda Kelly is 80 years old. She's as fit as someone decades younger and has an elite-level VO₂ max. Her easy daily habits add up to peak longevity.
Bryan Johnson says you should pay more attention to your resting heart rate
Your resting heart rate holds big clues to your overall health according to longevity influencer Bryan Johnson who spoke at BI Live's The Long Play.
Redefining health and value as we age
Explore Mayo Clinic’s Aging Forward podcast with Sir Muir Gray on healthy aging—fitness, prevention, self-care, and community support for longevity and purpose.
Industry leaders speak about AI at Business Insider's The Long Play
Some of the buzziest names in superintelligence, media, health, and longevity got real about AI's impacts at Business Insider's The Long Play.
Longevity enthusiast Bryan Johnson shares a test for biological age
Johnson led the exercise at Business Insider's The Long Play event in San Francisco on Tuesday. You can do it anywhere with a timer.
Why climate action matters for healthy longevity
Climate change is shaping how long and how well people live. Here’s how climate action can support healthier, longer lives and reduce growing longevity gaps.
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Can red light therapy really deliver a beauty and health glow up? Here's the science
Wellness influencers tout the therapy's power for everything from rejuvenating skin and hair to boosting longevity. Devices sold for at-home use abound. We look at the evidence behind the hype.
Scientists were wrong about lifespan. Your genes matter way more than we thought
For years, scientists believed our lifespan was mostly shaped by environment and chance, with genetics playing only a minor role. But a new study from the Weizmann Institute flips that idea on its head, revealing that genes may actually account for about half of the differences in how long people live. By analyzing massive twin datasets—including twins raised apart—and using innovative simulations to filter out deaths from accidents and other external causes, researchers uncovered a hidden genetic influence that had been masked for decades.
iPhone Fold’s Crease-Less Display Longevity Claims Will Be Scrutinized As OPPO Find N6’s Real-World Use Exposes Its Exaggerated Marketing
An OPPO Find N6 owner exposes the device’s false crease-less claims after a month of use, bringing pressure on Apple and its iPhone Fold
What the tech bros are getting wrong about longevity that you can get right
A whole industry revolves around longevity, but much of it misses the point. Kara Swisher learns what matters in the new CNN series, “Kara Swisher Wants to Live Forever.”
Kara Swisher examines the science, tech and business of living longer in new CNN docuseries
NEW YORK (AP) — Journalist Kara Swisher begins her new, six-part CNN series about longevity and health in an interesting location — a cemetery.
Kara Swisher examines the science, tech and business of living longer in new CNN docuseries
Kara Swisher begins her new CNN series on longevity and health in a cemetery, reflecting on her father's death | K-DAWN
My favorite health foods from Costco, from 65-year-old fitness trainer
As a personal trainer focused on longevity and healthy eating, I stock up on protein-filled foods like frozen chicken and Greek yogurt at Costco.
These simple lifestyle changes could decrease dementia risk by 25%
New research is the latest to show that people don’t need elaborate or expensive longevity hacks to stay mentally sharp as they age.
What Is Tmrw Longevity Powder? Here's what to know about the blue scoop
Tmrw Longevity Powder combines blue spirulina with a focused blend designed to support energy, clarity, digestion and healthy aging pathways.
45-year-old longevity researcher: How I keep my body and brain healthy—it's what 'your grandmother probably told you to do'
Jamie Justice's research focus is how to "prevent or delay the onset of functional declines, disability or chronic diseases" as people age, she says.
We've got a winner in our business-focused bracket
A champion has been crowned in our business-focused March Madness bracket: longevity. It won almost 67% of the more than 200 votes.
Chinese satellite with robotic 'octopus arm' passes key refueling test in orbit — making longer-lived space assets more likely
The experimental Hukeda-2 satellite and its highly flexible robotic arm have passed a major refuelling test in low Earth orbit. The demonstration is the latest step toward China significantly expanding the longevity of its spacecraft.
Cardiologist Reveals Favorite Exercise Class For Workout Variety
In TODAY.com's Expert Tip of the Day, a cardiologist reveals how she unexpectedly discovered a "really intense workout" and why a variety of workouts boosts longevity.
FDA Is Expected to Lift Restriction on Peptides, Heeding RFK Jr.’s Wishes
The peptides, which are increasingly marketed as providing longevity and health benefits, were removed in 2023 from the agency’s list of products that compounding pharmacies can sell.
Is longevity science stuck? Researchers call for a strategic reset
After decades of progress, longevity science may be facing a paradox: more knowledge, but limited impact. Some researchers now suggest the field may have failed not because of insufficient data, but because of flawed strategy.
The Biggest Pros And Cons Of GM's Vortec Engines
The biggest pros of GM's Vortec engines are their longevity, performance and efficiency. The biggest cons come from their oil consumption and use of AFM.
Canadian business stalls over US trade deal jitters
STORY: The Canadian manufacturing hub of Windsor is home to thousands of small and specialized part makers and caters primarily to car companies and equipment manufacturers. The city thrives on close integration with Detroit, America's automotive capital, just across the river.That means it's also on the frontline of tariff and trade uncertainty with Canada's largest trading partner. JACKIE RAYMOND: "Even if we don't directly work with the automotive industry, we indirectly do."Jackie Raymond is co-owner of FASTSIGNS, a Canadian company that designs and installs custom business signs and graphics.The company is coming off its toughest year since the pandemic. Orders from its core automotive clients dried up.And while a new project brought some relief, the company says customers are placing smaller orders, demanding longer payment terms, and bargaining harder on prices.:: FileIt all points to uncertainty tied to the United States-Mexico-Canada Agreement, which is up for review this year. It's a deal U.S. President Donald Trump has repeatedly said he could scrap.:: Washington, D.C. / December 2, 2025TRUMP: "...and we'll either let it expire or we'll maybe work out another deal with Mexico and Canada...":: FileThe agreement - known as CUSMA north of the border - exempts most Canadian goods from U.S. levies.While Mexico has started formal negotiations with the U.S. over the deal's renewal, Canada has so far only held informal talks.RAYMOND: "I think the CUSMA is very, very important because it trickles down to every little business right down to your barber shop and your nail shop, which will affect all of our customers."The situation in Windsor reflects a broader unease facing Canada's economy, which contracted 0.6% in the fourth quarter. About 90% of the city's exports cross the border, often multiple times during production.Manufacturing accounts for nearly a quarter of employment in the Windsor-Essex region.Its chamber of commerce, which represents about 750 businesses, says companies paused investments, delayed production, and cut jobs at the height of the tariff uncertainty last year. :: FileWindsor partly regained its footing as Trump exempted USMCA-compliant exports from Canada from tariffs in March last year.But uncertainty still drags on business confidence and Windsor's unemployment level remains one of the highest among major cities in Canada.Local shops complain of lower traffic and restaurants report thinner crowds.And builders say the housing market – often among the first sectors to show strain from the knock-on effects of tariff uncertainties – is near a standstill.Brent Klundert of BK Cornerstone, a local real estate builder, said he laid off 13 of his 21 staff as sales and prices slumped last year. "And you know, when people are going to make the biggest investment of their life, they really want confidence in their job, in the longevity of their job in the economy itself. And people lost that due to the tariffs.” // “If we can get through CUSMA, if we can get through our trade agreements with the US, I think that that will add a lot of confidence into the marketplace that we've been lacking.”Since January Klundert has rehired 10 of his employees, hoping homebuyers would start coming back.So far, only a few have.
How a Healthy Mind-Set Influences Longevity
A few qualities, including a sense of purpose, seem to have real benefits — especially as you age.
A geneticist is studying pythons for clues about human health and longevity
A team of researchers believes that pythons may contain clues to help treat a range of human ailments — from heart disease to muscle atrophy, and more.
The final four of Business Insider's business-focused bracket
The business-focused March Madness bracket narrows to four trends: SaaSpocalypse, tariffs, longevity, and robotics.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
The Longevity Bros Are Cold Plunging Wrong
The practice has its benefits. Just not the ones wellness influencers are loudest about.
Varying your exercise routine could add years to your life
Switching up your exercise routine does more than fight boredom. Engaging in varied forms of movement may significantly boost your longevity, according to research.
This overlooked organ may be more vital for longevity than scientists realized
The role of the thymus in our long-term immunity and health is poorly understood. A new study suggests we need to pay attention
Thymus may be critical to adult health
Research indicates the often-overlooked organ can be key predictor in longevity, disease risk, and cancer treatment outcomes.
Dick Van Dyke Credits His Longevity to One Habit, And Science Supports It
He turned 100 last year.
Can science slow down aging?
Geneticist Anne Brunet explores what aging really is, how lifestyle choices might influence longevity, and the promising frontiers of aging research.
Scientists Reveal the Simplest Rule for Building Strength
New resistance-training guidelines show that any amount of strength training can significantly improve muscle, strength, and physical function.
Scientists found a surprising way to make exercise work better
Exercise normally boosts the body’s ability to use oxygen, a key marker of health and longevity — but high blood sugar can block that benefit. Researchers found that a ketogenic diet helped mice normalize blood sugar and dramatically improved how their muscles responded to exercise. Their muscles became better at using oxygen and built more endurance fibers. The results suggest diet and exercise may work together in surprising ways to improve metabolic health.
How to Have a Longer and More Fulfilling Sex Life
With longevity comes the opportunity for an extended sex life, which some seniors find by staying active and open-minded.
Can Owning a Pet Help You Live Longer?
Research suggests pets keep you healthier. But there are some caveats.
Scientists reveal why a popular anti-aging compound may also fuel cancer
Polyamines—natural molecules found in every living cell—have become stars in the longevity world for their ability to boost cellular cleanup and support healthy aging. But there’s a dark twist: high levels of these same molecules are consistently seen in cancer, where tumors grow aggressively.
Hone Health Launches "Death To Midlife," Challenging the Language of Aging
Following a full-page open letter ad in the February 22, 2026 Sunday edition of The New York Times calling for the symbolic death of the word "midlife," Hone Health, the leader in longevity intelligence and personalized care, unveils a bold national campaign today: "Death To Midlife." Both an immersive pop-up experience and a cultural statement, the campaign includes a national digital "bury a word" activation on Hone's website, celebrity and influencer social activation, and a public installati
Biohacking To Business Travel: Hospitality As Longevity Laboratory
Why hospitality may be the real longevity laboratory—how everyday business travel is redefining healthspan, wellbeing, and the future of the longevity economy.
Barshop Institute to receive up to $38 million from ARPA-H, anchoring UT San Antonio as a national leader in aging and healthy longevity science - UT Health San Antonio
Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Feb. 24, 2026 – Positioning The University of Texas at San Antonio as a national anchor for aging and longevity science, its Sam and Ann Barshop Institute for Longevity and Aging Studies will receive up to $38 million in federal funding for the first nationwide clinical study […]
Barshop Institute to receive up to $38 million from ARPA-H, anchoring UT San Antonio as a national leader in aging and healthy longevity science - UT Health San Antonio
Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, Feb. 24, 2026 – Positioning The University of Texas at San Antonio as a national anchor for aging and longevity science, its Sam and Ann Barshop Institute for Longevity and Aging Studies will receive up to $38 million in federal funding for the first nationwide clinical study […]
Influencers are promoting peptides for better health. What's the science say?
The latest wellness craze involves injecting these molecules for athletic performance, longevity and more. Scientists say the research isn't keeping pace with the health claims.
Influencers are promoting peptides for better health. What's the science say?
The latest wellness craze involves injecting these molecules for athletic performance, longevity and more. Scientists say the research isn't keeping pace with the health claims.
Influencers are promoting peptides for better health. What's the science say?
The latest wellness craze involves injecting these molecules for athletic performance, longevity and more. Scientists say the research isn't keeping pace with the health claims.
6 Things You Should Never Add to Your Tea
Tea is a healthy beverage that promotes heart health and longevity, but adding the wrong things to your brew can diminish its health benefits.
Scientists May Have Found The Key Cellular Process Behind Aging in Animals
A new path to longevity?
Scientists May Have Found The Key Cellular Process Behind Aging in Animals
A new path to longevity?
The No. 1 Fruit to Eat for Longevity, According to a Healthy Aging Researcher
In TODAY.com's Expert Tip of the Day, a longevity researcher shares why this one fruit is so important for healthy aging and lowering chronic disease risk.
Five Berkeley Lab Scientists Receive DOE Early Career Research Awards
Five scientists from Lawrence Berkeley National Laboratory (Berkeley Lab) have received Early Career Research Program (ECRP) awards from the Department of Energy. The ECRP program, now in its 16th year, was established to bolster the nation’s scientific workforce by supporting exceptional researchers at the outset of their careers, when many scientists do their most formative work. Recipients use the funding to pursue projects that have the potential to solve scientific challenges and advance the country’s STEM capabilities. To be eligible for the program, a researcher must be an untenured, tenure-track assistant or associate professor at a U.S. academic institution, or a full-time employee at a DOE national laboratory or Office of Science user facility, who is within 10 years of having earned their doctorate. Awards to an institution of higher education will be approximately $875,000 over five years, and awards to a DOE national laboratory or Office of Science user facility will be approximately $2,750,000 over five years. This year’s Berkeley Lab awardees and their projects are listed below: Timon Heim: Better detectors for more powerful particle colliders Timon Heim is a staff scientist in the Physics Division. His ECRP project will develop a new type of detector that can track the particles generated by collisions in particle colliders with high spatial and temporal resolution. Current detectors in use at high-energy colliders, like the ATLAS detector at the Large Hadron Collider (LHC) at CERN, can track the trajectory and measure momentum of particles, but they can’t track a particle’s time of arrival with sufficient precision to discern from which of the many particle interactions they originate. Heim’s proposed technology — called a 4D tracking detector, because it captures data about particles’ positions in space and time — aims to solve this challenge, allowing researchers to glean more precise data from collision experiments to uncover new insights into fundamental forces and potentially discover new particles. The enhanced capabilities of 4D detectors will be a necessity for experiments at future colliders, such as the Muon Collider or Future Circular Collider. The project will develop custom microelectronics that process the signal of a pixelated silicon sensor that can register charged particles passing through it in an extreme radiation environment that these colliders produce during operation. The goal is to measure individual particles’ position with 50-micro-meter spatial and 50 pico-second (one trillionth of a second) temporal precision, for an incoming flux of around 1 billion particles per second per square centimeter. Harrison Lisabeth: Studying underground processes to unleash abundant energy Harrison Lisabeth is a research scientist in the Energy Geoscience Division focused on combining real-world experiments and AI to guide development of geothermal energy systems. His project will explore how deep underground rock formations – where geothermal wells are dug – are stressed by chemical reactions of the minerals and mechanical strain from movements in the Earth. A better understanding of subsurface stresses is essential to engineer safe and reliable geothermal wells that access the heat of deep rocks to produce electricity. It is estimated that the U.S. could generate ten times the amount of energy needed to power the grid using geothermal sources. Lisabeth plans to simulate how minerals grow, dissolve, and influence the behavior of surrounding rock in geothermal reservoirs by tracking chemical changes in rock samples under pressure in the lab. The project will also develop machine learning models to predict geologic strain based on field measurements and refine existing models that describe how common rock types deform under stress. Combining these approaches, Lisabeth hopes to develop a framework to predict stress to improve stability and longevity of geothermal wells. Daniel Carney: Pushing the quantum boundaries of particle measurement Daniel Carney is a staff scientist in the Physics Division who uses quantum information science to study particle physics and gravity. At very small scales, “quantum noise” — random fluctuations from the act of measurement — can drown out faint signals from rare processes. Carney’s ECRP project, “Fundamental Physics at the Quantum Limits of Measurement,” aims to build a new mechanical quantum sensor that can measure extremely small particle interactions below the limits of that quantum noise. The approach uses lasers to hold a tiny bead containing radioactive atoms; when one decays, the system measures the bead’s motion and the energy of any particles emitted. The experiment’s initial goal is to search for heavy sterile neutrinos, hypothetical particles predicted by some extensions of the Standard Model. The system could also help measure the mass of the neutrino, study the way particles interact through the electromagnetic and weak forces, and hunt for low-mass dark matter — all unsolved mysteries in particle physics. Callum Wilkinson: Using machine learning to demystify neutrinos Callum Wilkinson is a staff scientist in the Physics Division and part of the international Deep Underground Neutrino Experiment (DUNE) hosted by Fermi National Accelerator Laboratory. DUNE will create an intense beam of neutrinos that interact in detectors in Illinois and, after an 800-mile journey through the earth, in massive detectors in South Dakota. By precisely measuring neutrinos and how they change, researchers will get a better understanding of their fundamental properties and whether they are responsible for why there is so much more matter than antimatter in our universe. Wilkinson’s ECRP project will apply two machine learning techniques to improve the analysis of DUNE’s data and enhance the experiment’s precision. One approach will look for hidden patterns in how neutrinos interact and produce low-energy particles, while the other will help correct for distortions in what the detectors record. The methods will be tested on one of DUNE’s prototype detectors and could be used in other neutrino experiments, improving their measurements and helping scientists build better models. Aditi Krishnapriyan: Machine learning methods that scale as datasets grow Aditi Krishnapriyan is a faculty scientist in Berkeley Lab’s Applied Mathematics and Computational Research Division (AMCR) and assistant professor at UC Berkeley. Her project, awarded through UC Berkeley, will develop machine learning methods that scale with dataset size for modeling complex, multi-scale phenomena. The resulting tools can be applied in a wide range of research, including the study of new electrolytes for batteries or the examination of molecular interactions. ### Lawrence Berkeley National Laboratory (Berkeley Lab) is committed to groundbreaking research focused on discovery science and solutions for abundant and reliable energy supplies. The lab’s expertise spans materials, chemistry, physics, biology, earth and environmental science, mathematics, and computing. Researchers from around the world rely on the lab’s world-class scientific facilities for their own pioneering research. Founded in 1931 on the belief that the biggest problems are best addressed by teams, Berkeley Lab and its scientists have been recognized with 17 Nobel Prizes. Berkeley Lab is a multiprogram national laboratory managed by the University of California for the U.S. Department of Energy’s Office of Science. DOE’s Office of Science is the single largest supporter of basic research in the physical sciences in the United States, and is working to address some of the most pressing challenges of our time. For more information, please visit energy.gov/science.
Meet Aramore, The Science-First Brand Bringing NAD+ To Beauty
From Harvard-backed research to growing consumer demand, Aramore is bringing NAD+ longevity science into everyday skincare.