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Travelers Championship 2026: Scheffler, Spieth headline final signature event field
TPC River Highlands gets ready to host the Tour's final signature event of the season. Here are the notable names in the field.
Obama opens center with celebrities, rebuke of Trumpian politics
The current president – who wasn’t invited – was a notable omission from the ceremony, which featured former presidents Bill Clinton, George W. Bush and Joe Biden.
15 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Is Beaten-Down Phibro Animal Health Stock a Buy Following an Insider Purchase of 10,000 Shares?
This animal health provider, serving global livestock markets, reported a notable insider buy in its latest SEC filing.
Here’s what you missed: A week of big announcements in politics and law enforcement
It was a busy week across the Upstate, beginning with Primary Election Day and ending with some notable arrests and convictions. Here are some of the major stories you may have missed from this week.
Sinai Temple Gala, Black-Jewish Entertainment Alliance, 'Jewish Tomorrow' Podcast
Notable people and events in the Jewish LA community.
Blue Jays Adjust Alejandro Kirk's Role Ahead of Yankees Series
With Alejandro Kirk nearing a return, the Toronto Blue Jays made a notable adjustment ahead of a pivotal weekend series against the New York Yankees.
Engineering’s Shuo Li selected for Crain’s Cleveland Business’ 2026 Notable Leaders in Architecture, Engineering and Construction | CWRU Newsroom
Shuo Li, PhD, the Leonard Case, Jr. Professorship in Engineering at the Case Western Reserve University Department of Biomedical Engineering, was sele...
Spurs join a growing list of notable collapses in sports history
The San Antonio Spurs have plenty of company in being on the losing end of a dramatic comeback. Matt Ryan and the Falcons losing a 28-3 lead against New England in the Super Bowl.
Business Restructuring Review Vol. 25 No. 3 May-June 2026
In This Issue Texas Bankruptcy Court Adopts Barnet Rule Requiring Foreign Debtor to Have U.S. Assets to Be Eligible for Chapter 15 Relief In In re Siu-Fung Ceramics Holdings Limited, No. 24-33299, 2026 WL 382424 (Bankr. S.D. Tex. Feb. 10, 2026), the court denied petitions for chapter 15 recognition of Hong Kong bankruptcy and liquidation proceedings commenced on behalf of an individual debtor and a group of companies that he owned or controlled. According to the court: (i) the corporate debtors' Hong Kong liquidation proceeding was not eligible for chapter 15 recognition because the attorney retainer upon which such relief was based was not funded until nine months after the chapter 15 petition date; and (ii) the individual debtor's Hong Kong bankruptcy case could not be recognized because the debtor's "center of main interests" on the chapter 15 petition date was not in Hong Kong, and he did not even maintain an "establishment" there. [read more …] Southern District of Texas Clarifies Post-Purdue Course for Consensual Third-Party Releases and Gatekeeping Provisions In In re Container Store Group, Inc., 676 B.R. 356 (S.D. Tex. 2026), appeal filed, No. 26-20166 (5th Cir. Apr. 14, 2026), cross appeal filed, No. 26-20166 (5th Cir. Apr. 24, 2026), the U.S. District Court for the Southern District of Texas addressed consensual third-party releases and gatekeeping provisions in the aftermath of the U.S. Supreme Court's ruling in Harrington v. Purdue Pharma L.P., 603 U.S. 204 (2024). Consistent with existing Fifth Circuit precedent, the court confirmed that, in appropriate circumstances, consent for third-party releases may be obtained through a creditor's failure to opt out of granting that consent. But, the court ruled, consent through an opt-out mechanism essentially can never be inferred for creditor classes that stand to receive no recovery under a chapter 11 plan and that are deemed to reject the plan by operation of applicable bankruptcy law. Instead, those classes must affirmatively opt in to any release. The court also narrowed and remanded the bankruptcy court's acceptance of a broad gatekeeping provision, ruling that such provisions must correspond to the restrictions established by Fifth Circuit precedent. [read more …] Delaware Bankruptcy Court: Initial Transferee Need Not Be Defendant in Fraudulent Transfer Avoidance and Recovery Litigation The Bankruptcy Code gives a bankruptcy trustee the power to avoid asset transfers that are either made with the intent to defraud creditors or that are "constructively" fraudulent because an insolvent debtor did not receive adequate value in exchange. The Bankruptcy Code also permits recovery of an avoided transfer from not only the initial recipient, but also from subsequent transferees. Courts disagree over whether a transfer must actually be avoided before the trustee can seek recovery from a subsequent transferee and whether the initial transferee must also be a defendant in the recovery litigation against a subsequent transferee. The U.S. Bankruptcy Court for the District of Delaware weighed in on this debate in Phillips v. SS Associates LLC (In re ONH AFC CS Investors, LLC), No. 23-10931 (CTG), 2026 WL 312892 (Bankr. D. Del. Feb. 4, 2026). The court adopted the majority view, ruling that the initial transferee need not be a defendant in avoidance and recovery litigation against a subsequent transferee, but that the trustee must establish the elements necessary to avoid the initial transfer as part of the recovery litigation. [read more …] New York Bankruptcy Court Weighs In on Adequate Assurance of Future Performance under Assigned Leases and Chapter 11 Plan Exculpation Provisions In order to assume and assign an executory contract or unexpired lease, a bankruptcy trustee must cure most defaults under the agreement and provide "adequate assurance" of the assignee's future performance. However, the Bankruptcy Code provides no guidance as to the meaning of "adequate assurance" other than with respect to shopping center leases. In In re Broadway Realty I Co. LLC, No. 25-11050, 2026 WL 147505 (Bankr. S.D.N.Y. Jan. 19, 2026), the U.S. Bankruptcy Court for the Southern District of New York examined this issue in connection with a proposed assignment of thousands of residential leases as part of a free-and-clear sale of debtors' properties. The court held that "adequate assurance" does not mean a guarantee of the assignee's future performance, but merely demonstration that the assignee has the ability to satisfy the underlying obligations. The bankruptcy court also ruled that an exculpation provision in the debtors' chapter 11 plan exonerating non-estate fiduciaries from liability for actions taken in connection with the chapter 11 case was unobjectionable, provided it was limited in scope to postpetition conduct and actions taken in connection with implementation of the plan after its effective date. [read more …] Newsworthy Corinne Ball (New York) (Hall of Fame), Bruce Bennett (Los Angeles), Carl E. Black (Cleveland), Jeffrey B. Ellman (Atlanta), Brad B. Erens (Chicago), Gregory M. Gordon (Dallas), Heather Lennox (Cleveland/New York), Joshua M. Mester (Los Angeles), and Kevyn D. Orr (Washington) were included in the 2026 edition of Lawdragon 500 Leading Bankruptcy and Restructuring Lawyers. The Daily Business Review selected Isel M. Perez (Miami) as an "On the Rise" winner for the Florida Legal Awards. The Florida Legal Awards annually recognize those who have made significant contributions to the legal industry in Florida. Dan T. Moss (Washington/New York) was inducted as a Fellow in the 37th Class of the American College of Bankruptcy at its Annual Meeting in March 2026 in San Antonio, Texas. Christine Borries (Munich) was ranked in the practice area Restructuring/Insolvency in the 2026 edition of Chambers Germany. The 2027 edition of The Best Lawyers in Singapore™ recognized Sushma Jobanputra (Singapore) in the practice area Insolvency & Reorganization. The restructuring transaction involving Eissmann Automotive North America, Inc. received the "2025 Turnaround of the Year (Large Company)" at the Turnaround Management Association (Detroit) Annual Awards Reception. T. Daniel Reynolds (Cleveland) and Nick Buchta (Cleveland) represented subsidiaries of Eissmann Group Automotive in connection with the parent company's German insolvency proceedings. Roger Dobson (Sydney) is among 40 Jones Day lawyers recognized by The Best Lawyers in Australia 2027 for his contributions in Banking and Finance Law; Distressed Investing & Debt Trading; Insolvency and Reorganization Law; Litigation. An article written by Corinne Ball (New York) titled "Ard Finance—A Global Enterprise Combining an LME With a Foreign Insolvency Proceeding and Chapter 15" was published in the April 21, 2026, edition of the New York Law Journal. An article written by Alex Sapp (New York) titled "Recent Developments in Section 510—Subordination" was published in the 2025 edition of the Norton Annual Survey on Bankruptcy Law. An article written by Brad B. Erens (Chicago) titled "New York Bankruptcy Court Approves Insider DIP Litigation Financing" was published on April 6, 2026, by Lexis Practical Guidance. An article written by Corinne Ball (New York), Dan T. Moss (Washington/New York), David S. Torborg (Washington), and Isel M. Perez (Miami) titled "New York District Court Affirms Narrow Scope of 'Public Policy Exception' in Chapter 15 Cases" was published on April 6, 2026, by Lexis Practical Guidance. An article written by Jeffrey B. Ellman (Atlanta) titled "Statutory Cap on Lease Rejection Damage Claims in Bankruptcy Applies to Solvent Debtors" was published on April 6, 2026, by Lexis Practical Guidance. An article written by Trisha L. Mowbray (Real Estate; Chicago) and Ryan Sims (Washington) titled "Chapter 11 Plan that Abridged Non-Debtor Lessee's Rights to Remain in Possession After Rejection Unconfirmable as Having Been Proposed in Bad Faith" was published on April 6, 2026, by Lexis Practical Guidance. Lawyer Spotlight: Ben Rosenblum Ben Rosenblum, a partner in the New York Office, represents debtors, creditors, and other parties in out-of-court restructurings and court-supervised proceedings, including chapter 11 cases, municipal bankruptcies, international insolvency matters, and stockbroker liquidations. His experience spans industries such as manufacturing, shipping, mining, aviation, energy, real estate, and telecommunications. Ben's notable debtor representations include Peabody Energy, the City of Detroit, Chrysler LLC, Spansion Japan, and Dana Corporation. Significant creditor representations include General Maritime Corporation, Calpine Corporation, American Home Mortgage, and Murray Energy. He currently represents creditors in Puerto Rico's restructuring. He also has extensive experience advising financial institutions on bankruptcy law as applied to derivatives.
NYC Health + Hospitals/Bellevue Director of Capital Design and Construction Yunjung Lee Recognized by Crain's New York Business as a 2026 Notable Leader in Architecture
NYC Health + Hospitals today announced that Yunjung Lee, Director of Capital Design and Construction at NYC Health + Hospitals/Bellevue, has been named to
NYC Health + Hospitals/Bellevue Director of Capital Design and Construction Yunjung Lee Recognized by Crain's New York Business as a 2026 Notable Leader in Architecture
NYC Health + Hospitals today announced that Yunjung Lee, Director of Capital Design and Construction at NYC Health + Hospitals/Bellevue, has been named to
'Probably the most visibility the city will receive through sports globally, maybe ever’: Notable quotes from a week of Chattanooga area news
People who had a way with words in the news last week:
An Early Mock Trade To Give The Pirates’ Bullpen Help
The Pittsburgh Pirates’ bullpen is about as bad as one can get while not rebuilding. They’ve caused multiple late blown leads and heartbreaking disasters. The unfortunate reality is that no notable relievers are getting moved yet. ESPN’s Buster Olney even reported this. However, there might still be an opportunity for the Pirates to add someone. …
Wie West's journey back ends with missed cut at Riviera
2014 U.S. Women's Open winner Michelle Wie West carded a 75-74 in her two rounds at Riviera putting her behind the projected cut. Here are some other notable names not making it to the weekend.
Illinois state Rep. Kam Buckner meets Pope Leo XIV in the Vatican
The week after Chicago Mayor Brandon Johnson and a delegation of 45 other Chicago notables met with Pope Leo XIV in the Vatican, another Chicago politician got to meet the pope too.
Mid-Century Modern Home for Easy Entertainment in Ft. Thomas
This home was designed by one of Cincinnati’s most notable modern architects and stopped passersby in their tracks.
What Makes Barrett Business Services (BBSI) a Good Investment?
Schafer Cullen Capital Management, Inc., an independent investment advisor, released its Q1 2026 investor letter for the “Small Cap Value Equity Strategy.” You can download a copy of the letter here. U.S. equity markets started 2026 with notable volatility due to geopolitical events and shifting macro conditions. The Russell 2000 rose 0.9% for the quarter, […]
Opponent Snapshot: Minnesota Golden Gophers
Head Coach: PJ Fleck (10th year, 66-44 at Minnesota, 96-66 overall) 2025 Record: 8-5 overall, 5-4 Big Ten Quick 2025 Recap Minnesota completed its second straight 8-5 season, thanks to an overtime win over New Mexico in the Rate Bowl. Their most notable wins from the season include a snowy 17-7 win over bitter rival […]
8 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Why Mike Onwenu's revised contract with Patriots is notable news
The Patriots freed up some cap space Friday by signing Mike Onwenu to a revised contract, and that could hint at bigger moves to come.
Heroes of Might and Magic: Olden Era reveals early access roadmap as publisher Hooded Horse celebrates 1m copies sold during its first month
Hooded Horse and developer Unfrozen have announced Heroes of Might and Magic: Olden Era has sold 1m copies so far and revealed a notable roadmap.
Microsoft rolls out Windows 11 KB5089573 update that makes your PC genuinely faster and more responsive
Windows 11 update KB5089573 is now generally available as Microsoft's non-security preview update for May, and is packing genuinely notable performance improvements.
Apple Watch glucose monitoring project gets encouraging update
Apple wants to bring noninvasive glucose monitoring to Apple Watch, and a new report indicates the project has hit a notable turning point.
Early preview of the Ravens’ most competitive positional battles
The Baltimore Ravens made plenty of notable additions to their roster through free agency and the draft this offseason. While the potential still exists for them to make more signings this summer, their full crop of players is largely set as OTAs continue and training camp is on the horizon. As usual, there will be […]
Scripps National Spelling Bee guide: How to watch, who the notable spellers are, rules and prizes
Continuing a more than century-old tradition, the Scripps National Spelling Bee runs from Tuesday through Thursday this week.
Tourism gains spread across California with Sacramento seeing big results
A Visit California study shows the state's tourism economy is thriving, with Sacramento experiencing notable increases in visitor spending and hotel tax revenue.
10 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Atlanta theater notables Topher Payne, Charlie Cote happy as life co-stars
Atlanta theater notables Topher Payne and Charlie Cote are happy being life co-stars, collaborating on projects and scripting how to lend support to other stage artists.
Fighting game notables are asked if they'd prefer Final Fantasy's Tifa Lockhart to join Street Fighter 6 or Tekken 8
Final Fantasy is beginning to see more notable crossovers into the fighting game genre. Super Smash Bros. Ultimate got Cloud Strife and Sephiroth while Tekken 7 would eventually guest star Noctis Lucis Caelum.Tekken 8 would continue the trend by ...
Oh, Hello: Utah DT Aniti Paiva Commits To Penn State
THE SKINNY Height/Weight: 6-foot-3, 300 poundsHometown/High School: Draper, Utah (Skyline H.S.)Ranking: ★★★ (87 Rivals — No. 94 DT)Notable Offers: Arizona, Boise State, Colorado, Oregon State, Washington State HIGHLIGHTS OUTLOOK Kalani Sitake might have turned down the Penn State job, but the Nittany Lions are still in the Utah business thanks to defensive tackles coach Ikaika […]
Notable Standouts and Disappointments in the Sabres’ Playoff Run
The Buffalo Sabres’ season came to an abrupt end when Alex Newhook scored the Game 7 overtime goal to bring the Montreal Canadiens to the Eastern Conference Finals. Buffalo’s season is over, but it was a year of triumph and memories that will stick with the Sabrehood. In the playoffs, some players stood out, while […] The post Notable Standouts and Disappointments in the Sabres’ Playoff Run appeared first on The Lead.
5 Notable Moments From Candace Owens’s Warm Interview With Hunter Biden
In a nearly two-hour conversation, Mr. Biden discussed his addiction to drugs and alcohol, and Ms. Owens apologized for her past remarks about him.
AI & Science: What Is the Future of Discovery?
Continued progress in artificial intelligence, its expanding usefulness in science, and its contributions to landmark advances suggest that we may have entered a new era of AI for science.The breakthroughs so far—such as predicting the structure of practically every known protein, with profound implications for our understanding of biology, health, and the treatment of disease—are notable not only for what was achieved but also how it was achieved and what that suggests for scientific progress. This special double issue of Dædalus poses the question: What is the future of scientific discovery in this new age of AI? Thirty-three scientists responded. Bringing perspectives from life sciences and medicine, cognitive science and neuroscience, the physical and earth sciences, chemistry and materials science, computer science, mathematics and the social sciences—they draw on their work at the frontier of AI and science. The authors write with an eye to the future, not just the present. They explore what is being achieved and what possibilities lie ahead; examine AI’s limitations and efforts to move forward; and investigate the larger implications of AI-assisted science—on how science is done, the role of the scientist, and the scientific method, as well as the challenges and complexities involved.The authors together exemplify a long-standing bidirectional relationship: AI advancing science, while science advances AI. Where that relationship will take us—a golden age of discovery? New scientist-machine collaborations? Autonomous labs? Discoveries without human understanding?—is a future we are only beginning to imagine, and one we must also shape if the beneficial possibilities are to be realized.Image: UMAP sculptures visualizing three Dædalus volumes on artificial intelligence. © 2026 by Refik Anadol.
Everything Google announced at I/O 2026: Gemini, Search, Android XR, & more
We've collected all the consumer-facing announcements and notable developer developments made at Google I/O 2026 below.
The Republican senators speaking out against Trump
Sen. Bill Cassidy joins a short but notable list
Notable San Francisco Designer’s Napa Valley Ranch for Sale
Ken Fulk's restored ranch property in St. Helena boasts a two-bedroom cottage, entertainment barn, tent bungalows and a “Cowboy Shack.”
Ohio State football is high up on CBS Sports' post-spring college football rankings ahead of a notable team
Spring football has been over for a few weeks for the Ohio State Buckeyes.
11 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
First Public macOS Kernel Exploit on Apple M5 Prepared Using Mythos Preview in Five Days
Apple's M5 silicon has reportedly been exploited for the first time in a public macOS kernel memory corruption attack, successfully bypassing the company's notable hardware-level memory protection.
4 Takeaways From France's World Cup Roster Selection
Even with some notable omissions and Kylian Mbappé's drama at Real Madrid, this France squad is simply the team to beat.
France 2026 World Cup Roster: Real Madrid's Eduardo Camavinga Among Notable Omissions
France named its World Cup squad, with surprise goalkeeper call-up Robin RIsser highlighting Didier Deschamps' final tournament roster as France aims for another title.
Employee misconduct is becoming harder for companies to ignore
Rising workplace misconduct is becoming a growing concern for employers, with new research suggesting the problem may be rooted in shifting attitudes toward ethics and accountability, Inc. writes. A U.K. fraud prevention survey found notable tolerance for behaviors like expense fraud, moonlighting for competitors and even selling company login credentials, while a separate U.S. survey […]
Google accounts no longer get 15GB of free storage, only 5GB until you link a phone number
Google has made a notable change to its account storage policy, limiting the usual 15GB of free storage only to...
Barack Obama appears with James Talarico and Gina Hinojosa at Austin restaurant
The former president greeted patrons while stopping for tacos near the University of Texas at Austin campus — a notable show of support for the Democrats atop the ticket this fall.
iOS 26.5’s Apple Maps app has two notable changes, here’s what’s new
Apple Maps is one of several apps with new features in iOS 26.5, the latest iPhone update. Here’s what’s new for Maps users.
Live Results: Nebraska midterm state and congressional primaries
One of the more notable matchups in Nebraska’s state primary on Tuesday features two Democratic contenders for U.S. Senate who accuse each other of being “fake” candidates with no intention of competing to win the general election.
Rats, other vermin spark notable restaurant closures by L.A. health department
A review of L.A. County records by The Times tallied more than 120 vermin citations issued to food facilities in the region in 2026, with 67 — the majority — of these occurring in April alone.
Sponsors kill two bills to roll back $450 million in business tax breaks | The Sum and Substance
The bills sought to pare down two notable business tax breaks and to decouple state policy from federal tax laws speeding up depreciation.
B&H Introduces New Low Prices On 2026 MacBook Pro and MacBook Air
B&H Photo has introduced a handful of notable MacBook Pro and MacBook Air discounts this week, all of which beat the current Amazon discounts on these notebooks. B&H Photo is a trusted authorized Apple reseller that sometimes offers great deals on brand new Apple products. Note: MacRumors is an affiliate partner with B&H Photo. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running.
KFF Health Tracking Poll: Public Views on Foreign Aid and Global Health Spending
This poll finds that less than half of the public now wants the U.S. to play at least a major role in improving the health of people in developing countries. When asked about the administration’s changes to foreign aid and global health, more people perceive a negative impact than a positive one.
11 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Chief Justice John Roberts says Supreme Court doesn’t have ‘purely political actors’
Supreme Court Chief Justice John Roberts said Wednesday that the nation’s highest court doesn’t feature “purely political actors,” comments that come after a notable decision affecting the Voting R…
Concerts tours are dying from ‘blue dot fever’
Notable artists are dealing with lagging sales at arenas and stadiums
iOS 26.5 Coming Soon With These New Features
iOS 26.5 is expected to be released this May, following more than a month of beta testing. The update is relatively minor so far, which is not too surprising given that Apple is starting to shift its focus towards iOS 27. iOS 26.5 lays the groundwork for end-to-end encryption for RCS in the Messages app and ads in the Apple Maps app, and it will include a new Pride wallpaper and a few other changes. Below, we outline all of the notable additions in iOS 26.5.
12 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Trump’s Vision for D.C. ‘Garden of Heroes’ Statues Grows in Size and Cost
Plans for the project include formal gardens, reflecting pools and plazas alongside the statues of 250 notable Americans, according to documents obtained by The New York Times.
Melco Resorts & Entertainment Limited (MLCO) Releases Q1 2026 Earnings: EPS Up, Revenue and Gross Profit Down
Melco Resorts & Entertainment Limited (MLCO) reported Q1 2026 results with notable swings across revenue, profitability and cash flow.Total revenues: $1.4 billion (down 44.55% year-over-year).Gross profit: $513.2 million (down 84.15% year-over-year).Operating profit: $179.0 million (up 23.54% year-over-year).Net income attributable to common shareholders: $76.8 million (up 136.17% year-over-year).Diluted earnings per share: $0.20 (up 150.0% year-
EU business investment rate hit 21.8% low in Q4 2025
In the fourth quarter of 2025, the EU business investment rate reached 21.8%, the lowest point since the third quarter of 2015. Since 2014, the EU’s non-financial corporation investment rate has shown 2 clear trends, with notable spikes. Between 2014 and 2018, the investment rate rose steadily from 22% to nearly...
The 5 Most Interesting Analyst Questions From PENN Entertainment’s Q1 Earnings Call
PENN Entertainment’s first quarter was marked by strong performance in both its retail and interactive businesses, leading to a notable positive market react...
Arkansas Health Insurance Marketplace Data Show Changes in Enrollment, Plan Selection, Premiums
New data from the Centers for Medicare and Medicaid Services show that marketplace plan enrollment in Arkansas decreased by 3.8% in the 2026 open enrollment period compared to 2025, but there was a shift in the types of plans selected and a notable increase in average plan premiums.
Can’t-miss entertainment lineup at Hollywood Casino Joliet this summer & fall
Notable performers include comedians Margaret Cho and Deon Cole, and rock tribute band Hairball.
Team Canada adds big names to men's world roster
Team Canada has added a handful of notable names to its roster for the upcoming Men’s World Hockey Championship.
Zeeland Twp. to discuss solar filing with MI Public Service Commission
There are several notable meetings coming April 27-May 1 near Holland.
2026 NFL Draft Day 3 live picks tracker with grades: Every selection in Rounds 4-7
Day 3 of the 2026 NFL Draft is here. USA TODAY Sports will be tracking all 157 remaining selections and providing grades for the most notable picks.
Elon Musk among donors to Cincinnati congressmen
Campaign contribution documents revealed notable donations made to congressional candidates in Greater Cincinnati.
Democracy scholar David Campbell elected to American Academy of Arts and Sciences
David Campbell, the Packey J. Dee Professor of American Democracy at the University of Notre Dame, has been elected to the American Academy of Arts and Sciences, one of the nation’s oldest learned societies and independent policy research centers. Campbell was one of the 252 leaders in academia, the arts, journalism, policy, and science announced today as members of the newest Academy class. Other notable names among the group include actor and director Jodie Foster, writer Barbara Kingsolver, stage and screen legend Rita Moreno and novelist Colson Whitehead.
Democracy scholar David Campbell elected to American Academy of Arts and Sciences
David Campbell, the Packey J. Dee Professor of American Democracy at the University of Notre Dame, has been elected to the American Academy of Arts and Sciences, one of the nation’s oldest learned societies and independent policy research centers. Campbell was one of the 252 leaders in academia, the arts, journalism, policy, and science announced today as members of the newest Academy class. Other notable names among the group include actor and director Jodie Foster, writer Barbara Kingsolver, stage and screen legend Rita Moreno and novelist Colson Whitehead.
NASCAR Cup Series entry list for Talladega in April 2026
Check out the NASCAR Cup Series entry list for the 2026 Jack Link's 500 at Talladega Superspeedway including the most notable drivers!
Health Care Affordability
At Penn LDI’s convening at Penn Washington, leading experts found notable consensus on the drivers of health care costs, and some potential paths forward.
Where's Gridlife? Where's Adam Carolla? Road America president explains
A notable absence on Road America's 2026 schedule is the Gridlife Apex Music & Motorsports Festival it had hosted the two previous summers.
Great Women of Science Go Missing: The Matilda Effect
It’s now been two years since Great Women of Science debuted, featuring women who have made notable contributions to science, technology, or health and have largely gone unnoticed, often with Nobel prizes they deserved awarded to the men with whom they collaborated. There’s a name for this phenomenon - it’s called “the Matilda Effect.”
Xiaomi 18 Pro Max leak reveals Snapdragon 8 Elite Gen 6 Pro and more details
Details have leaked about an upcoming Xiaomi phone, which is expected to be the Xiaomi 18 Pro Max. The device is said to bring notable upgrades, including the Snapdragon 8 Elite Gen 6 Pro chipset.
12 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
NYU Langone Health neurologists present latest clinical findings and research at AAN 2026
This year’s meeting features more than 80 presentations from Department of Neurology faculty. Here are notable highlights: practical strategies to counter harmful medical myths and misinformation, phase 3 clinical results for a novel epilepsy medication, and the barriers patients with disabilities face while navigating outpatient facilities.
Fantasy Basketball: LeBron James, Jalen Duren among notable free agents
In addition to actual free agents, some player option situations will significantly affect fantasy basketball this summer.
Indiana Fever fans react to 2026 WNBA Draft haul
Following the completion of the 2026 WNBA Draft, here are some of the most notable social media reactions to the Indiana Fever's three selections.
Athens restaurant scores range from perfect to problematic
Health inspections show a mix of perfect scores and notable violations at various Athens restaurants.
Ethan Rii | Notable Leaders in Health Care 2026
Ethan Rii, partner in the national health care group at Ice Miller, is one of Crain's Chicago Notable Leaders in Health Care 2026.
Who missed the cut at the Masters? Notables sent home after Friday
The second round of the 2026 Masters is in the books and the 36-hole cut has been made. See the notable names who were sent packing Friday.
New iPhone Fold leaks cover ‘Ultra’ name, launch timing, more
iPhone Fold rumors keep coming, and today new posts from notable leakers cover the ‘iPhone Ultra’ name, launch timing, and more.
William Wertheim Named One of Crain’s New York Business 2026 Notable Leaders in Healthcare
Recognition highlights leadership in advancing Stony Brook Medicine as an integrated academic health system serving Long Island William Wertheim, MD, MBA, executive vice president of Stony Brook Medicine, has been named one of Crain's New York Business 2026 Notable Leaders in Healthcare. This prestigious recognition honors professionals who have demonstrated exceptional leadership in healthcare, driven
New York Giants’ star defender Dexter Lawrence salary demands revealed
The NFL is not only preparing for the 2026 NFL Draft—it has already begun voluntary workouts. Teams are now seeing players report for workouts, recovery plans, and general wellness checks. One notable name is absent from the New York Giants’…
Samsung updates One UI software rollout roadmap
On March 6, Samsung shared its April 2026 software rollout roadmap. It’s important information for every Galaxy device user. The company has made some notable changes in this month’s roadmap, compared to March 2026. Current Models for Monthly Security Updates Samsung offers new security updates to premium Galaxy phones and foldables on a monthly basis. […]
NYC Health + Hospitals Leaders Recognized by Crain's New York Business Among '2026 Notable Leaders In Health Care' - NYC Health + Hospitals
NYC Health + Hospitals today announced NYC Health + Hospitals/Bellevue Chief Executive Officer Dr. Eric Wei, NYC Health + Hospitals/Bellevue Department of
NYC Health + Hospitals Leaders Recognized by Crain's New York Business Among '2026 Notable Leaders In Health Care' - NYC Health + Hospitals
NYC Health + Hospitals today announced NYC Health + Hospitals/Bellevue Chief Executive Officer Dr. Eric Wei, NYC Health + Hospitals/Bellevue Department of
Elina Svitolina climbs into Serena Williams’ ranking territory
Elina Svitolina hits ranking milestone matched only by Serena WilliamsSince returning to the WTA Tour following her pregnancy in 2023, Elina Svitolina has experienced a notable resurgence in her career. The Ukrainian has picked up three WTA titles since then, the most recent being the ASB Classic at the beginning of the 2026 season.
Politics made Alabama power bills high. Politics can lower them.
The Alabama Legislature's attempt to protect state utilities from public outrage over high power bills has a notable weakness.
9 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
MLB 2026 Buzz: Reds Nick Lodolo to Make Rehab Start
Notable news, notes and buzz from MLB's 2026 season.
'Ferris Bueller's Day Off' book reveals the '80s star who almost beat out Matthew Broderick for title role
Another notable John Hughes collaborator could have portrayed Ferris Bueller, according to an upcoming book about the production of 'Ferris Bueller's Day Off.'
Windows 11 KB5086672 rolls out after Microsoft pulls failed March 2026 optional update
Windows 11 KB5086672 is now rolling out as an optional update with several notable improvements after March 2026 update issues.
11 Cool New Gadgets to Keep on Your Radar
Catching you up on the past week’s most notable product releases.
Two Commanders' contracts among 15 most notable this offseason
The Commanders have been busy this offseason, but two contracts stand out above the rest.
Elon Musk Joins in Phone Call Between Donald Trump and Narendra Modi
Mr. Musk’s participation was notable because it is rare for a private citizen to be on a call between heads of state. It also suggests that Mr. Musk is back on better terms with the president.
Windows 11 KB5079391 out with features, direct download links for offline installers (.msu)
Windows 11 KB5079391 is available as an optional update, and there are several notable improvements. One change that stands out is support for 1000 Hz refresh rate monitors; another is the ability to turn Smart App Control (SAC) on or off without reinstalling the OS. Microsoft has also posted direct download links for KB5079391 offline […]
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Apple’s busy March continues with three notable arrivals this week
Apple has had a jam-packed March so far after launching seven new products and surprisingly announcing an eighth. Looking ahead,...