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What to know about perimenopause and menopause
Discussing the transition, symptoms and treatments available for people going through menopause or perimenopause.
Judge pauses pied-à-terre tax rollout after homeowners allege botched launch
Staten Island Judge Wayne Ozzi heard arguments on a motion for a temporary restraining order to block the rollout of the pied-à-terre tax.
Sanders Calls on A.I. Companies to Pause Development to ‘Avoid Disaster’
Senator Bernie Sanders warned that corporations have already lost control of technology that could cause “potentially cataclysmic results” for millions of people.
AbCellera women’s health data top ‘most aggressive upside scenario,’ putting Astellas and Bayer on notice
AbCellera has reported phase 2 results “beyond even the most aggressive upside scenario” that its CEO dared to consider, boosting the biotech’s chances of challenging Astellas and Bayer for a women’s health market. The phase 2 clinical trial compared ABCL635, an antibody targeting NK3R, to placebo in patients with hot flashes caused by menopause. Investigators enrolled 92 postmenopausal women experiencing a mean of about 10 moderate or severe hot flashes per day. By Week 4, the number of moderate or severe hot flashes had fallen by a mean of 8.8 on ABCL635 and by 3.5 on placebo. That statistically significant, placebo-adjusted reduction of 5.3 hit the trial’s primary endpoint. The level of efficacy also cleared the bar set by existing drugs. While cross-trial comparisons can be misleading, AbCellera CEO Carl Hansen, Ph.D., had seen enough to start hyping the program. “We now view ABCL635 as a potential best-in-class non-hormonal therapy with strong differentiation against approved NK3R competitors across all important dimensions, including efficacy, safety, dosing and convenience,” Hansen said on a Monday morning conference call with investors to discuss the data. “We believe ABCL635 is now a highly de-risked program.” Last week, Hansen used AbCellera’s earnings call to set expectations for readout, with the CEO defining success as a clean safety profile and efficacy comparable to the two approved small molecules. The data vaulted over that bar. Astellas linked (PDF) one of the small molecules, Veozah, to placebo-adjusted reductions in hot flash frequency of 2.1 and 2.6 at Week 4 of its two phase 3 trials. Bayer reported (PDF) placebo-adjusted reductions of 3.04 and 3.29 at Week 4 of pivotal studies for its small molecule, Lynkuet. At 5.3, the placebo-adjusted reduction in AbCellera’s trial comfortably cleared the standard set by the incumbents. Veozah and Lynkuet came to market based on evidence of their ability to reduce the frequency and severity of hot flashes. AbCellera’s phase 2 study covered both endpoints, with the Canadian biotech reporting a mean reduction in severity of 1.4 points at Week 4 on ABCL635, compared to 0.3 points for placebo. Again, the placebo-adjusted result compares favorably to data on Veozah and Lynkuet. Analysts shared Hansen’s enthusiasm for the data. The phase 2 results “firmly validate ABCL635 as a potentially best-in-class treatment,” BMO Capital Markets analysts said in a note to investors Monday. ABCL635’s apparent efficacy edge “is likely attributable to the higher dosing/target engagement the asset is able to reach vs. the oral agents due to its wider therapeutic index,” the analysts added. The analysts, who model $2.3 billion in unadjusted peak sales for ABCL635, flagged the safety profile as another positive of the phase 2 readout. While Veozah carries a boxed warning for liver damage, nobody on ABCL635 in the phase 2 trial had elevated liver enzymes or bilirubin values. If replicated in phase 3, the lack of a liver signal could allow approval without the monitoring requirements imposed on Veozah. Investors appeared equally enthused, sending AbCellera's stock up 32% to $9.21 in premarket trading Monday from a Friday closing price of $6.93. Next, AbCellera will collect the Week 12 data and talk to its advisors about further development. The results open up “a wide variety of possibilities of how we might take this forward into phase 3 studies to truly maximize the value of the asset and make sure that ABCL635 is able to demonstrate its differentiation potential,” Sarah Noonberg, M.D., Ph.D., AbCellera’s chief medical officer, told investors.
Weir Science: A Fare-Thee-Well to Bob Weir
Photo by Chloe Weir Photography The Grateful Dead ushered in an era of open-minded experimentation and endless touring that paused occasionally but never really expired until its participants did. It follows that saying goodbye to cofounding Grateful Dead guitarist/vocalist Bob Weir, who passed away at age 78 on January 10, 2026, truly signifies the end of an era.
FULL SHOW: Inside INdiana Business 8/9/26
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Everyone's talking about hormone therapy for menopause. Should I be on it?
For years doctors advised women against hormone therapy for women in the menopausal transition. Now everyone's talking about how great it is. Is it really a wonder drug that women should all be on?
Sanofi suspends chronic lung disease phase 2 study, tied to ‘strategic business reasons’
Sanofi halted a phase 2 trial testing a monoclonal antibody, SAR445399, in non-cystic fibrosis bronchiectasis, Fierce Biotech has learned. The trial, which began only back in April, was a randomized, double-blind, placebo-controlled study to measure the reduction in mucus plug score following treatment with SAR445399 compared with placebo in adults aged 18 to 80 years with NCFB, a chronic lung disease. The trial was officially reported as halted on July 29, the day before Sanofi’s second-quarter earnings call. The decision to pause the trial was made “as part of a company-wide portfolio review for strategic business reasons,” and not due to safety concerns, a Sanofi spokesperson told Fierce. The move to pause the NCFB trial comes during a trying time for Sanofi following a year filled with a series of trial fails. In February, the French pharma ousted CEO Paul Hudson and appointed Merck KGaA leader Belén Garijo, M.D., Ph.D., to steer the ship. Since then, Garijo has been doing a deep dive on correcting the company’s strewn R&D and clinical strategies. On July 24, Sanofi scrapped amlitelimab for atopic dermatitis, despite its lore as being a potential $5 billion blockbuster. During its second-quarter report, the company abandoned two more assets, balinatunfib and itepekimab, following failed trial results in psoriasis and chronic obstructive pulmonary disease, respectively. SAR445399, only first revealed by Sanofi in 2023, is an anti-interleukin-1 receptor 3 monoclonal antibody developed to block the interleukin 1, 33, and 36 cytokine pathways. These pathways can be important in chronic immune-related dermatologic diseases, such as atopic dermatitis and hidradenitis suppurativa, as well as respiratory conditions, such as NCFB. Related Sanofi’s new CEO ‘looking deeply’ at late-stage pipeline as clinical clearout continues NCFB affects roughly half a million people in the U.S., with a global incidence of greater than one million cases. In August 2025, Insmed received FDA approval for Brinsupri, a DPP1 inhibitor targeting neutrophil activation, for treatment of NCFB in adults and kids ages 12 and older. The British biotech Infex Therapeutics showed promising NCFB phase 2a data using their monoclonal antibody, INFEX702, which acts by disabling Pseudomonas aeruginosa, a bacteria known to be a major pathogen of NCFB. Sanofi is currently running a separate phase 2 study testing SAR445399 as a potential treatment for the inflammatory skin condition hidradenitis suppurativa.
Marquette poll: Trump approval rating ticked up when gas prices were lower
Gas prices fell during the pause in the Iran War in June and early July.
Orlando pauses business incentive program for downtown due to high demand
Orlando had to pump the brakes on new applications for its CRA business incentives program after receiving more interest than expected.
Coby Bryant Injury Threatens Bears-Seahawks Reunion
Coby Bryant’s Chicago debut hits a painful pause, but the former Seahawks safety could still return in time for a heated Week 8 reunion with Seattle this fall.
Countries put science and precaution above race to start deep seabed m
More member states of the International Seabed Authority announced support for a precautionary pause or moratorium during its annual meeting, citing a lack of science and concerns for the long-term ef
Ariana Grande pauses concert, explains why she’s taking break in emotional speech: ‘Boundaries need to be set’
“My fans were worried that negativity was running things for me,” Grande said on stage, later adding that “human beings can need a break sometimes.”
Countries put science and precaution above race to start deep seabed m
More member states of the International Seabed Authority announced support for a precautionary pause or moratorium during its annual meeting, citing a lack of science and concerns for the long-term ef
Google pulls AI feature after users create fake satellite images
Google paused a new AI feature in Google Earth after it created realistic fake satellite images.
Brawl and BVB defeat in Vietnam: the wildest friendlies ever
The World Cup has now been over for almost two weeks. And club football is on pause too. In short: we’re right in the middle of the football summer slump!At first, that sounds dull and uneventful. B...
OPEC+ has agreement in principle for September quota increase and pause thereafter, source says
OPEC+ has agreed in principle to raise oil output targets by about 188,000 barrels per day from September and then pause for the fourth quarter, a source with knowledge of OPEC+ talks said on Sunday.
The hidden costs of delaying a commercial construction project
When business owners postpone a commercial construction project, the decision is often driven by good intentions. Delaying a project doesn't pause its costs. In many cases, it simply changes where those costs show up.
South Florida Medicaid families say kids with autism are losing therapy as state cuts and insurer pause add up
The Politics Hour: Montgomery County pauses data centers
Montgomery County At-Large Councilmember Shebra Evans on pausing data center development, D.C.'s Shadow Representative Oye Owolewa on his recent primary win in the D.C. At-Large Council race, and what's next for aging Rock Creek Tennis Center?
Flawed studies linking hormone therapy to breast cancer made doctors reluctant to prescribe it for menopause relief – especially for breast cancer survivors
Menopausal hormone therapy no longer has the highest-level warning label about the risk of breast cancer, opening a gray area on who would benefit most from treatment.
‘Extremely violating’: Tinder pauses AI photo enhancement feature
"It was extremely violating," Rubin said. "Those are not my teeth. That's not what my mouth looks like."
Tinder pauses AI tool after it gave some daters an unsolicited makeover
An in-app “Photo Enhance” tool altered some users’ appearances without their permission. Tinder told NBC News that the unintended changes affected a small number of users.
Novant Health operations impacted from Forsyth County water main break
Novant Health has shifted some clinics to virtual visits and paused elective surgeries after a major Forsyth County water main break.
Tech Stocks Tumble on Worries About A.I. Spending and China’s Chip Competition
South Korea temporarily paused trading on Tuesday as its benchmark stock index led losses across the region, closing more than 10 percent lower.
Can Susan Collins defy political gravity again?: From the Politics Desk
Plus, oil prices drop as the U.S. and Iran pause strikes.
Parkrose Enhanced Service District Proposal Paused After Pushback from Business Owners
The proposal to create a new Enhanced Service District in the Parkrose neighborhood of Northeast Portland has been paused after community members protested the plan.
Oil price slides as US and Iran pause fire; cancer treatments help AstraZeneca beat profit forecasts
Rolling coverage of the latest economic and financial news
Oil prices ease after US and Iran pause their attacks
Oil prices have fallen further in early trading after setting a two-month high set last week.
Oil slips more than 5% after US pauses strikes on Iran
Oil prices extended losses on Monday, falling more than 5%, after U.S. President Donald Trump paused strikes on Iran after two weeks of attacks, raising hopes of a diplomatic solution that may de-escalate the conflict in the Middle East.
Why it took so long to talk about perimenopause
For too long, women’s health was treated as an afterthought. We still haven’t caught up.
‘Menopause Cocktail’: Can Allergy, Acid Reflux Meds Help Alleviate Symptoms?
The "menopause cocktail" involves taking allergy medications along with acid reflux medications. Proponents say the viral trend helps with menopause symptoms like hot flashes and brain fog, but experts warn it may carry risks.
Vance, Caine raised munitions stockpile concern, source says, as US pauses consecutive nights of strikes in Iran
Vice President JD Vance and Chairman of the Joint Chiefs of Staff Gen. Dan Caine both raised concerns about the US munitions stockpile to President Donald Trump as he weighed potentially escalating the war with Iran during a White House meeting on Friday, a US official told CNN.
Parkrose neighborhood residents push back on ‘sloppy’ business district
PORTLAND, Ore. (KOIN) — A contentious proposal to create a new business district in Northeast Portland is on pause after pushback from property owners who would be paying more fees. “It…
Health inspections remain paused at ICE detention center in Tacoma
The Ninth Circuit Court of Appeals hit pause, for now, on allowing state health inspectors into the Pacific Northwest's largest ICE detention center.
After backlash, Meta pauses plan to ‘rate limit’ its smart glasses
A paywall is still coming, though.
Colombia Schools, Businesses Urged to Go Remote on Natural Gas Pause
Colombia’s government is urging schools and businesses to operate remotely for several days starting next week as the nation braces for natural gas rationing during planned maintenance of its sole import terminal.
🏀 Y! Sports AM: Alone at the top
The Lynx are head and shoulders above the rest of the WNBA as the league hits pause for the All-Star break.
Health inspections of Tacoma ICE center remain on pause as legal battle continues
The Northwest ICE Processing Center in Tacoma remains closed to state health inspectors despite a judge’s order two weeks ago opening the region’s largest immigrant detention center to state officials.
Oakland pop-up restaurant owner pauses business after home break-in, sexual assault of 16-year-old son
Oakland police are searching for a suspect following a terrifying Monday morning break-in that ended in the sexual assault of a 16-year-old boy.
Melinda French Gates says it took 3 doctors to diagnose the condition she was suffering from
Melinda French Gates says it took three doctors to diagnose her perimenopause, revealing a startling gap in OB-GYN menopause training nationwide.
Melinda French Gates Struggled to Get Perimenopause Care
The philanthropist said that even in her “unbelievably privileged situation,” it took three different doctors to diagnose her.
NY Attorney Letitia James praises federal judge’s ruling to pause entertainment industry merger
A FEDERAL JUDGE’S restraining order on Monday halts an $81 million Paramount/Warner Brothers Discovery merger.
Paramount's WBD deal is on pause after judge orders merger delay
A judge issued a temporary restraining order stopping Paramount Skydance's acquisition of WBD after a lawsuit by California and 11 other states.
Moonshot just gated new users from its new Kimi model
The Chinese AI startup said it saw massive demand over the last two days and had to pause new subscriptions to reduce strain on its GPUs.
Small Business Technology News Roundup: IBM Shares Crash, ChatGPT To Replace Wall Street Analysts
IBM shares collapse, OpenAI says AI will replace workers, Upwork says AI is reshaping freelancing, Microsoft will let you pause Windows 11 updates, Expensify consolidates travel billing
Opinion | Double standard over GLP-1 drugs hits women especially hard
Women experience the effects of obesity in many ways, including heart disease, certain cancers, fertility challenges, maternal health complications, and more severe menopause symptoms.
Long-term study shows how neighborhood conditions shape women's heart health
Women who live in disadvantaged neighborhoods face worse heart health and experience faster decline as they approach menopause, according to a long-term study led by the Harvard Pilgrim Health Care Institute.
Community, business leaders back Hochul's pause on hyperscale data centers
Gov. Kathy Hochul held a roundtable Thursday morning, defending her decision to put a moratorium on new hyperscale data centers.
Adam Silver says NBA didn't 'pause' Kawhi Leonard trade, that Raptors, Clippers did; confident probe will end before new season
Majority of Fort Worth Council supports data center pause. Will it happen?
The majority of Fort Worth City Council wants a temporary moratorium on data centers. A supermajority is needed. This comes after the Fort Worth Zoning Commission voted not to recommend new rules for data centers within the city. Lone Star Politics speaks with Councilwoman Elizabeth Beck, one of the leaders of the effort.
Hochul enacts first statewide data center moratorium
Her executive order will pause the permitting process for up to a year to evaluate environmental impacts.
Health department rescinds freeze on $10 billion for 5 Democratic states
The reversal of the funding pause came after the administration faced repeated setbacks in a suit challenging the decision, which could have jeopardized programs for low-income households.
Health Dept. Rescinds Freeze on $10 Billion for 5 Democratic States
The reversal of the funding pause came after the administration faced repeated setbacks in a suit challenging the decision, which could have jeopardized programs for low-income households.
The Quintessential Trump-era Politician
In 2020, I wrote an article about collaboration and collaborators. The title was History Will Judge the Complicit, and it started with the story of two famous East Germans, Markus Wolf and Wolfgang Leonhard, who both landed in East Berlin just after the end of the war. Although they came from very similar backgrounds, the former stuck with the regime, eventually becoming its spy boss; the latter, horrified by the brutal reality of Soviet-style communism, escaped. By way of juxtaposition, I also wrote about Lyndsey Graham and Mitt Romney. These two men also made very different decisions when confronted by Donald Trump’s assault on the ideals that they had both grown up believing: A glance at their biographies would not have led many to predict what happened next. On paper, Graham would have seemed, in 2016, like the man with deeper ties to the military, to the rule of law, and to an old-fashioned idea of American patriotism and American responsibility in the world. Romney, by contrast, with his shifts between the center and the right, with his multiple careers in business and politics, would have seemed less deeply attached to those same old-fashioned patriotic ideals. Most of us register soldiers as loyal patriots, and management consultants as self-interested. We assume people from small towns in South Carolina are more likely to resist political pressure than people who have lived in many places. Intuitively, we think that loyalty to a particular place implies loyalty to a set of values. But in this case the clichés were wrong. It was Graham who made excuses for Trump’s abuse of power. It was Graham—a JAG Corps lawyer—who downplayed the evidence that the president had attempted to manipulate foreign courts and blackmail a foreign leader into launching a phony investigation into a political rival. It was Graham who abandoned his own stated support for bipartisanship and instead pushed for a hyperpartisan Senate Judiciary Committee investigation into former Vice President Joe Biden’s son. It was Graham who played golf with Trump, who made excuses for him on television, who supported the president even as he slowly destroyed the American alliances—with Europeans, with the Kurds—that Graham had defended all his life. By contrast, it was Romney who, in February, became the only Republican senator to break ranks with his colleagues, voting to impeach the president. “Corrupting an election to keep oneself in office,” he said, is “perhaps the most abusive and destructive violation of one’s oath of office that I can imagine.” In the wake of Graham’s unexpected death on Saturday, I wrote about him again. He was, in many ways, the quintessential politician of Trump’s Washington, a man who shifted 180 degrees. Graham had been a fervent American patriot, proud reserve officer and military lawyer; he became one of the most important defenders of a president who believes soldiers are “suckers and losers” and shows no respect for law of any kind. As his politics changed, his language grew coarser and his behavior grew worse: He urged Israel to “level the place” in Gaza, and insulted the Danish prime minister in Munich, prompting a colleague, Senator Elissa Slotkin, to issue an apology. Here’s an excerpt from the article, which you can read in The Atlantic (gift link here) Like his close friend John McCain, Graham believed that America should stand at the center of a broad democratic alliance. The few times I met him were in that context, at the Munich Security Conference or at other European-American gatherings, which he once attended with great regularity. He also took seriously the practice of American democracy at home. In a 2014 conversation with The Atlantic, he described himself as a pragmatic politician who eschewed populist slogans. “I know Washington is broken, but what’s broken about it is everybody yelling and nobody trying to fix it,” he said. “I’m trying.” When Donald Trump first appeared in U.S. politics, Graham recognized him immediately for what he was: the spokesman for an alien ideology, one radically different from the idealistic patriotism that Graham had practiced and preached since childhood. Trump privately mocked the military that Graham loved as nothing but “suckers and losers.” He put falsehoods, cynicism, and personal greed at the center of his politics, while expressing disdain for transparency, accountability, and democracy itself. In 2015, Graham described Trump as a “race-baiting, xenophobic, religious bigot” who should “go to hell.” Also as a “nutjob.” When Trump won, Graham understood, as did so many others, that he would have to make some important choices. For a while, he went silent. In the spring of 2016, I saw him at one of those conferences in Europe. He seemed too depressed to speak. But then, like many other Republicans—and, more important, like many other people who have lived under political occupation or experienced radical regime change—he made the decision to abandon his previous ideals, to bury the patriotism that was once so important to him, and to become, instead, a loud, opportunistic collaborator. As I wrote in 2020, it’s very hard to look in to anyone’s heart and to understand their motivations from the outside. But it does seem that Graham had a deep need to be relevant, to be in the game, to be a player, at any cost. And that, rather than any particular achievement, is what he will be remembered for. Continuing to monitor conflicts of interest, ostentatious emoluments, outright corruption and policy changes that will facilitate outright corruption. (Read my original article, Kleptocracy Inc and check out the SNF Agora Institute chart) June 27 Trump diverted funds from more than 900 projects nationwide—including safety upgrades at national parks—to finance beautification projects around Washington, including $700,000 used to fix a White House walkway. June 28 After a years-long Department of Justice investigation into Abbott Laboratories over its management of a baby formula facility where potentially deadly bacteria turned up enough evidence to criminally charge the firm, top department officials instead opted for a financial penalty—illustrating the department’s move away from strict corporate enforcement under the Trump administration. June 29 Defense Secretary Pete Hegseth stacked the Defense Policy Board—which is charged with providing independent national security recommendations to the Office of the Secretary of Defense—with Trump allies, including tech billionaire Marc Andreessen, who has invested in defense contractors like OpenAI and SpaceX, after purging the panel last year. Trump purchased between $1 million and $5 million worth of stock in Axon—which makes about 90% of US tasers—two weeks before ICE solicited bids for a $220 million taser contract. The White House unveiled limited-edition US passports for America’s 250th birthday, featuring a portrait of Trump overlaid on the Declaration of Independence. June 30 Trump made around $1.2 billion from his various crypto companies last year, including more than $500 million from World Liberty Financial and $600 million from sales of his meme coin. Trump is considering issuing 250 pardons to commemorate America’s 250th birthday. These are expected to be largely doled out through the Office of the Pardon Attorney’s informal network of intermediaries. White-collar defense attorneys say they can typically win pardons for clients for $2 million. Last year, Trump administration officials awarded a no-bid contract worth up to $500 million to Clark Construction for the White House ballroom—negotiations in which the president was directly involved. July 1 The Amazon MGM Studios documentary about Melania Trump earned the First Lady more than $10 million. Trump made hundreds of individual stock purchases worth as much as $12.8 million the day before his announcement pausing “Liberation Day” tariffs for 90 days sent the S&P 500 soaring nearly 10%—one of the largest single-day gains ever. Mar-a-Lago and Trump National Doral saw record surges in revenue during Trump’s first year in office, earning $77.5 million and $121.9 million respectively, compared to average annual revenues of $25 million and $75 million during Trump’s first term. Entities across the Persian Gulf paid more than $300 million to Trump’s businesses last year, including $263 million from the sale of half his stake in World Liberty Financial to a firm backed by Sheikh Tahnoon bin Zayed Al Nahyan, a top UAE royal and brother of the country’s president. Kash Patel failed to properly disclose his stock purchase of a Department of Justice contractor, MicroStrategy, worth up to $250,000 last year, despite laws requiring disclosure within 45 days of the trade. July 2 Trump has been directing administration officials to steer more government contracts—so far worth more than $2.4 billion—to Jeff Bezos’s Blue Origin aerospace firm, after Amazon gave $1 million to Trump’s inaugural fund, donated to the White House ballroom project, and reached a $40 million deal to license a Melania Trump documentary. Alongside the billions he made from cryptocurrency last year, Trump earned millions of dollars from real estate licensing fees, including $21 million from organizations in the UAE and $9.2 million in Saudi Arabia, along with smaller sums from merchandise sales, including $4.7 million from Trump Watches and $35,920 from 45 Guitar, a guitar brand endorsed by the president. House Democrats accused consultants tied to the Trump administration of financial fraud, alleging they gave prospective donors to America250—the bipartisan committee created by Congress to celebrate the nation’s semiquincentennial—the banking and routing numbers for Freedom 250, the White House’s fund for events like the UFC cage fight. Democrats also allege that Freedom 250’s CEO traveled to the World Economic Forum in Davos to solicit donations from foreign government officials and business leaders. The Trump administration’s proposed rollback of gun regulations would lift the prohibition on mailing handguns to individuals, a significant win for GrabAGun—the direct-to-consumer firearm retailer on whose board Donald Trump Jr. sits and in which he holds a 1.1% ownership stake. GrabAGun currently must rely on a middleman to transfer firearms to customers. Trump’s financial disclosure revealed that he made more than 21,000 securities trades during his first year back in office, growing his investment account to at least $858 million across stakes in around 1,600 companies, compared to the 13 total trades Joe Biden made during his entire presidency. July 4 Nearly 1 million people who bought the president’s meme coin—Trump Coin—collectively lost $3.8 billion on the token, while he walked away with $636 million. July 6 Shares of Dell closed up 4.4% after Trump recommended people buy the firm’s computers during a speech announcing the launch of Trump investment accounts for children, boosting the more than $1 million worth of shares the president owns in the company. July 9 Federal Reserve Chair Kevin Warsh named crypto investor and Trump ally Marc Andreessen to a task force aimed at modernizing the Federal Reserve, including rethinking its approach to inflation—a key factor keeping interest rates elevated. Palm Beach International Airport has officially changed its name to Trump International Airport—a move that will require Florida to pay royalties to the president’s family for licensing his name. I was there a few months ago, during a trip to Barcelona. The sculptures were a revelation, I’d never seen so many together before. Each one has its own personality. Enjoy the good weather, if you are lucky enough to have it. History Will Judge the Complicit The Quintessential Politician Autocracy Inc Open Letters, from Anne Applebaum is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
AB Science ends three studies in multiple sclerosis, other immune conditions
The trials, which were testing the tyrosine kinase inhibitor masitinib, had previously been paused. AB Science’s decision not to resume them was a matter of prioritization, not safety, the biotech said.
FULL SHOW: Inside INdiana Business 7/12/26
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West Virginia Department of Health pauses cleanup at Wood County warehouse fire site
The West Virginia Department of Health has issued a temporary cease and desist order pausing cleanup efforts at the site of the fire at Peoples Cartage Warehous
Marina Moscone Presses Pause on Her Business
In an exclusive interview, sisters and cofounders Marina and Francesca Moscone, weigh in on their decision to suspend operations—for now. “This has definitely been a heavy, heartfelt decision, a very emotional one for us,” the designer said. “We knew entering this industry and this business of our own, fashion is turbulent and joyful all the time.”
Doc strikes out on her own with hormone therapy practice Lumineux Health near Willow Lawn
An OB/GYN and former partner at Virginia Physicians for Women, Amanda Vaughan said she started Lumineux after seeing a need from women experiencing perimenopause and menopause.
Lionel Richie 'doing well' after tour pauses for health issue
Lionel Richie seems to be moving past the unspecified health issue that prompted him to postpone a pair of shows on his summer tour with Earth, Wind & Fire. 'I’m doing well,' he says.
Flooding pauses most of Preston business until Wednesday
Excessive rainfall across much of southeast Minnesota caused river flooding. That flooding, pausing one business’ operations during its peak season.
FULL SHOW: Inside INdiana Business 7/5/26
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'You want to put your health over money': Landscapers pause work during extreme heat
Extreme Heat Safety: Local landscaping company takes day off to protect workers
Negotiations between Cherriots, business leaders paused after months of meetings
Talks between the Salem Area Mass Transit District and representatives from a coalition of six business and real estate groups, and citizens were halted last week, Cherriots said in a press release. The two groups formed a task force to find a compromise after a proposed payroll tax sparked frustration last year. To comment on this story, use the form at the end of the report.
Oregon store pauses Yu-Gi-Oh! card game competitions after complaints about players’ hygiene
The issue of hygiene in competitive gaming has prompted major publishers, including Yu-Gi-Oh! publisher Konami, to enact formal regulations in the past
Baton Rouge General’s Health Tip of the Week: Man, it’s hot in here!
Sponsored by Baton Rouge General Night sweats affect nearly 45% of adults at some point, and while it might not be talked about as much as it is with women and menopause, men do experience those middle-of-the-night wakeups drenched in sweat. Low testosterone disrupting the body’s temperature regulation system is a big culprit, but there […]
Ovaries Appear to Develop an Incredible Second Role After Menopause
The human body continues to surprise us.
New US-Iran clashes revealed fragility of truce — and why it may work
An apparent agreement by the US and Iran to pause a fresh outburst of violence stabilized a truce that is the first step to permanently ending the war and underscored that each side has a vital national interest in doing so.
Atlanta businesses push back on proposed liquor license pause as leaders seek to curb Edgewood Avenue violence
Edgewood Avenue business owners back public safety improvements after recent violence, but some say pausing new liquor licenses won't solve crime's root causes.
National Science Foundation finds no violations in Texas A&M research security contract
U.S. Rep. John Moolenaar, a Michigan Republican who chairs the House of Representatives' select committee on China, had urged the NSF to pause funding for a project known as SECURE.
Consumer Discretionary Stocks Drawing Institutional Rotation Into Live Entertainment Leaders
With the Federal Reserve hinting at a pause in rate hikes, stubborn inflation still in the background, and several large companies surprising on earnings, consumer discretionary stocks are back in focus for investors weighing risk and opportunity. This article looks at how that mix of easier policy signals, solid corporate reports, and ongoing geopolitical and supply chain issues could affect larger U.S. consumer-focused companies. It will walk through 3 stocks from a curated screener that...
Netflix’s New #1 Show Is a Crime Thriller Everyone Can Finally Agree on
A new Netflix thriller has taken over the number 1 spot, knocking a usual chart-topper down the rankings. Viewers are calling it binge-worthy, twist-filled, and impossible to pause once you start. Find out more here.
Indian shares set to pause after oil-led rally
Indian shares were set to open flat on Tuesday, with analysts expecting a phase of consolidation in the absence of fresh triggers after gains in six out of seven sessions, while sentiment remained constructive on easing Middle East tensions.
How menopause radically changes the brain
The brain undergoes a full renovation during menopause. Although these changes are profound, we’re learning that the long-term impact needn’t be all bad
There's 'menopause legislation' in the works. What does that mean?
More than half of the states have introduced or passed menopause bills including requiring insurance companies to cover hormone therapy.
Rock star pauses mid-concert to ask crowd for World Cup game score
"You can think of tonight as a gathering to celebrate the World Cup, with some music interspersed.”
Opinion | Menopause and the Failure of Women’s Health Care
Readers respond to “Menopause Should Not Be Such a Mystery,” an Opinion guest essay by Melinda French Gates.
FULL SHOW: Inside INdiana Business 6/21/26
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ZenniHome ex-business partner accuses Bob Worsley of creating LLC ‘without her consent’
After eight long days of investigating, the Navajo Nation Council has paused its public hearing into the ZenniHome scandal until next month. But in subpoenaed testimony from earlier this week, a key witness made a bombshell allegation against her ex-business partner.
Kennedy Center asks judge to pause deadlines in ongoing lawsuit as it explores options for renovation
The Kennedy Center on Friday asked a federal judge for more time to comply with deadlines in an ongoing lawsuit over its looming closure as the center’s board explores avenues for renovation.
Waymo recalls nearly 4,000 robotaxis after cars enter freeway work zones
Waymo has paused freeway robotaxi operations and recalled nearly 4,000 vehicles after more than a dozen incidents involving autonomous cars entering closed construction zones.
Oral Health and Menopause Lunch and Learn Highlights Need for Interdisciplinary Care
Program explored the intersection of menopause, oral health, and health equity during National Oral Health Month
West Hartford Business Buzz: June 15, 2026 - We-Ha
A round-up of openings, closings, and other news about West Hartford businesses. Business Buzz is sponsored by NBT Bank, and we are very thankful for their support! By Ronni Newton We've just about reached that time of the year when I would like to hit pause and stay here for a
Judge denies DOJ request to pause removal of Trump's name from Kennedy Center
A federal judge had ruled May 29 that physical and digital signage with President Donald Trump’s name must be taken down within 14 days
Exclusive: US military rushed to prepare ground mission to capture Iran’s uranium, but Trump paused it, sources say
The US’ top general made a secret, rushed visit to US Central Command headquarters in Florida late last month to be briefed in person on plans for the US military to send ground troops into Iran to forcibly seize its highly enriched uranium, the key component necessary to produce a nuclear weapon, two sources familiar with the matter told CNN.
Taylor Swift pauses speech after getting emotional on stage in moving family tribute
Taylor Swift cried on stage in a moving speech dedicated to her family after she broke a major music industry record: 'They uprooted their entire lives.'
Surprising ways menopause can affect your mouth
Hormone changes during menopause can mess with your dental and oral health. Here’s how experts recommend managing the effects.
Using AI for medical advice; pelvic floor exercises; the hidden dangers of burning incense; plus other stories with Vanderbilt Health sources
Colin Walsh, MD,Associate Professor of Biomedical Informatics, was on WTVF News Channel 5‘s “Morningline” show in an interview about whether or not it is safe to use AI for medical advice. Time magazine reporter Stacey Colino interviewed Elisabeth Sebesta, MD, Assistant Professor of Urology, for a story about pelvic floor exercises for issues including menopause, erectile dysfunction and urinary incontinence in men. “Each Breath,” published by the American Lung Association, quoted Brian Christman, MD, Adjunct Professor of Medicine, for a story about the hidden dangers of burning incense. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Healthline (low vaccination rates lead to more cases of measles, whooping cough and other preventable diseases); ABC News (U.S. measles cases surpass 2,000 for second year in a row); and CIDRAP News (high-dose flu shots cut rates of hospitalization in older adults). Sarah Rohde, MD, Associate Professor of Otolaryngology-Head and Neck Surgery, was quoted in a People magazine story on patient Makalii Andrade, a surfer from Kauai Island who suffered a serious neck injury in 2022 and recently underwent surgery at Vanderbilt Health to begin the final phase of his recovery. James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a piece in Nature about antibodies against a strain of Ebola. SFGATE reporter Gillian Mohney interviewed Xue Zhong, PhD, Research Assistant Professor, Division of Genetic Medicine and Clinical Pharmacology, for a story about a study of a blood test looking at Alzheimer’s disease biomarkers. Matthew Franklin Mart, MD, Assistant Professor of Medicine, was quoted in a Healio story about how inflammation and illness severity is linked to less cognitive resilience after a person has been an ICU patient. The “How We Really Feel” podcast host Sula Windgassen, PhD, interviewed Lindsey C. McKernan, PhD, MPH, Associate Professor of Psychiatry & Behavioral Sciences, Physical Medicine & Rehabilitation and Urology, for an episode focusing on pelvic and bladder health. The podcast is also available on YouTube and the podcast website. In addition, podcaster Monica Sanford interviewed cardiologist Mark Glazer, MD, for her podcast “The Monica Sanford Show”; the two-part interview is here and here.
New OMB rule could break science in the United States
The drug that saved your mother. The treatment your doctor recommended. The clinical trial that bought someone you love more time. None of it was inevitable. It required a system built to operate outside politics and sustained over decades, because science doesn’t operate on the timeline of a politician. That system is now under direct threat. The Office of Management and Budget (OMB) has proposed a new rule to regulate all federal grants, not just science, but housing, education, defense, NASA and everything in between, that would fundamentally change how research is conducted in the United States. There have been a lot of fires in the past 16 months, and if everything is an emergency, nothing is an emergency. But this is a very big deal. These rules would strip away the independence that has kept science from becoming a political tool. The good news is there’s still something we can all do. How the grant system was designed to work When I was a new faculty member, I was full of millions of ideas, so I sat down and wrote an NIH proposal. I worked on it for months and thought it was so good. Then I sent it to my mentor. It came back covered in comments. Places where my reasoning wasn’t as airtight as I’d thought, methods that could be stronger, gaps in my thinking that I had been too close to the work to see. It stung, as honest feedback always does, but peer review almost always makes the work better. In fact, it’s the backbone of how American science has functioned for generations. At NIH, submitted proposals go to a panel of scientists who have experience in the field. These are the people who can read research methods and spot their weaknesses, who understand when an experiment is designed well and when it isn’t. Applications are scored rigorously, and often only the top 3-20% of proposals receive funding. The people making funding decisions are required to justify them based on these reviews. To be clear: this is not a perfect system, and good science still goes unfunded more often than any of us would like due to limited resources. There is also criticism that peer review may undervalue bold ideas that are risky but could have high payoffs. But the peer review system is nonetheless a meaningful part of the grant selection process. While thoughtful and careful changes could improve the system, the changes being proposed by OMB will not make things better. The rule that could change everything Through this OMB proposal, the system that helps decide what gets funded is being dismantled. There are many troubling elements buried in this proposal, but three provisions stand out in particular. Each would be damaging alone. Together, they would change what kind of science gets done in America, and who it serves. 1. Political appointees would decide which science gets funded, and peer review would be explicitly sidelined or ignored. The guidelines your doctor follows, the standards that determine what’s in your air and water, the drugs that get approved for your family: all of it starts with a funding decision. Right now, that decision is made by scientists who can evaluate whether the work is actually sound and whether it could move the needle forward. Under this proposal, funding decisions could be made by political appointees. The careful, expertise-driven review process that shapes grant funding would be effectively sidelined. That means that a poorly designed study could get funded simply because someone in a political office liked the sound of it, while rigorous, important work doesn’t get funded because it no longer aligns with the administration’s priorities. In other words, critical work that benefits all of us could now be missed just because it has become politically inconvenient. 2. Grants could be canceled at any point, without warning, in the middle of ongoing work. Say your tax dollars have been paying for a cancer study for two years. The grant was awarded for five years, so the team is mid-experiment. There are three additional years’ worth of answers that could change how the disease is treated for hundreds of thousands of people. With this new rule, the federal government could cancel the remaining funding tomorrow, walk away from the commitment it made with your money, and have no legal obligation to finish what it started. This is a huge waste of money. There are rarely other sources of funding for this work, which means the team, the graduate students, postdocs, and research staff who have dedicated years of their careers to this project could lose their jobs. Patients who have contributed their time to studies may not see it turn into useful learnings for others. Every hour of work already completed could result in nothing useful. Science can take decades to get to tangible outcomes. It needs a stable funding system to flourish. 3. Researchers would have a harder time communicating their findings without pre-approval from the federal government. There is a saying from Sir Mark Walport: “Science isn’t finished until it’s communicated.” Science is no use to anyone if it is kept locked away in the labs that produced the data. The proposed rule could make communicating research findings harder in a number of ways: Make it harder for scientists to widely share their findings in scientific journals. Publication costs, including journal fees that allow for broad public access, could not be paid for by federal funds which is often how scientists pay these costs. Restrict researchers from engaging publicly about how their findings should inform policy or public health guidelines. This would restrict scientists from doing the work that transforms years of lab work into decisions that actually affect people’s lives. Make it harder for scientists to attend conferences. Conferences would now need to be approved by the federal agency at the time of grant award. This disadvantages conferences or publications that are not politically aligned. Conferences are a key way in which scientists learn about work happening in their field so they can collaborate and build on each other’s findings. What good is science with a muzzle? The long-term impact These changes could (and hopefully would) be reversed under the next administration. But by then, damage has been done. Once projects are halted or denied funding by political appointees, people leave their science careers for other paths or even leave the country to do their amazing science elsewhere. You cannot pause a scientific study the way you pause a subscription you decided isn’t useful anymore. You cannot freeze a research team that depends on salaries to feed their families, causing a scramble for replacement funding that, in most cases, simply does not exist. When the money stops, everything stops, and all the work in progress and its potential are lost. Despite all of the language about reducing waste, fraud, and abuse, this new proposed rule increases the administrative burden tremendously. Every researcher watching this unfold will make a rational decision: don’t start anything that will take a decade to finish. This includes not building a team around funding that could vanish, or asking the big questions that need patience and stability to answer. The most consequential science, the kind that produces the treatments and the breakthroughs that reach your doctor’s office twenty years from now, is exactly the science that would be abandoned first. This is still a proposal, so we can all do something Some worry this rule is already a done deal. But by law, OMB is required to open a public comment period. Those comments matter because they inform members of Congress, they can be used in litigation, and they create a public record. So here’s what you can do: Submit a public comment. The public comment period on this proposed change is open until July 13. Anyone can submit a comment, and OMB is required to respond to substantial ones. Each comment must be different to count as distinct; identical comments will be counted only once. Comment as an individual, not on behalf of your organization. Here’s a full resource to help you, with useful examples, but in general: Share a story about how science or federal funding has benefitted you or is involved in your work. Are you or someone you loved a cancer survivor? Do you know someone with Alzheimer’s? Have you received NIH/NSF or other federal funding? All of these can be stories you use to highlight why you care. Explain why you’re worried about these proposed changes. You can use the wording found here or in other resources to help you. Ask them to withdraw this proposed rule. Contact your elected representatives. Congress allocates money to federal agencies to spend, and it has oversight of how that process works. You can let your representatives know this proposed change concerns you and ask them to intervene. There are levers they can push that can help at this moment. Let others know why federal funding matters. This isn’t just about science, but ALL federal grants, including for education systems, defense projects, and more. The process, including the importance of federal funding, is invisible to many. We can all make it more visible by sharing how science benefits us and why we value it. You can also share this article, or any of the resources linked here, to help spread awareness! Bottom line We are quickly losing ground in scientific research in the U.S. More changes, like the proposed rule by OMB, would decimate our ability to conduct research here, leaving us all worse off: fewer treatments for pancreatic cancer, less research on pollution impacts, fewer answers for patients with rare disease, and more unaddressed health needs. The impact will be very real for all of us, regardless of where we stand politically. Using our voices for science is more important than ever. Love, LM Big thanks to Dr. Megan Ranney for reading this over and providing brilliant insights, as always. Dr. Liz Marnik, PhD, is Executive Director of The Evidence Collective at YLE and a science communicator and immunologist working at the intersection of public trust, science, and public health. You can find her on Substack, LinkedIn, Instagram and Threads. Your Local Epidemiologist (YLE) comprises a team of experts, ranging from physicians to immunologists to epidemiologists to nutritionists, working together with one goal: to “Translate” ever-evolving public health science so that people are well-equipped to make evidence-based decisions. The YLE suite of newsletters reaches over 475,000 people across more than 132 countries. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Falcons QB battle takes curious pause
The Atlanta Falcons are passing their quarterback battle. Will the delay hurt the eventual starting quarterback?
Justin Moore Is Hitting Pause on Touring to Focus on His Health: ‘This Is the Right Decision’
The artist is expected to return to the road for his July show in Illinois.
Apple's Health app can now tell you if you're in perimenopause
Cycle tracker will now notify women when their cycle patterns are suggestive of perimenopause.
Apple's Health App Now Supports Both Menopause and Perimenopause
Announced at WWDC 2026, Apple's Health app supports cycle tracking for menopause and perimenopause.
ProBiotix Health targets long-term women’s health beyond menopause symptom support
Women’s health research is growing, and scientists are learning that supporting consumers through menopause means going beyond addressing symptoms. Cellan Davies, head of marketing at ProBiotix Health, tells Nutrition Insight which menopause-support ingredients and formulation approaches are gaining the most traction within women’s health.
Menopause event aims to go ‘beyond the scale’
The event is part of the center’s ongoing “Beyond the Scale” series and will feature two regional medical experts specializing in menopause care.
FULL SHOW: Inside INdiana Business 6/7/26
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