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Kosta Nedeljkovic Returns for Serbia to Hand Rangers Fitness Boost
Rangers defender Kosta Nedeljkovic has returned to action for Serbia against the Netherlands after missing four club matches through injury.
Xavi gets first win as Netherlands boss, Denmark beat Wales
The Netherlands gave Xavi Hernandez his first win as head coach with a 2-1 Nations League victory over Serbia in Belgrade on Sunday, while Denmark saw off Wales.In League B, Austria made it two wins from two as David Affengruber, Junior Adamu and Carney Chukwuemeka scored in a 3-1 win over Kosovo in Vienna.
Vučić resigns as Serbia prepares for both parliamentary and presidential elections
Vučić has faced growing pressure from student-led protests
2026 Vanderbilt Football Mailbag #5: Call For Submissions
Post VANDERBILT Football and/or SEC Football questions in the comments here. The offense put us in position to get punt-blocked. …and Curtis lost his first SEC game in the Land of A Million Mascots. …and I’m sure you all have questions. Here are the rules of the mail bag: …and that’s it.
Orbitals Game Review
Despite the gorgeous veneer, the characterization and writing in Orbitals don't have anywhere near the same amount of gas that everything else in it does.
Vanderbilt football vs Georgia game time, TV channel announced
See Vanderbilt football's game time and TV info against Georgia in a Week 5 SEC road game.
Bay Area retirement community grapples with disturbing incidents
Rossmoor, an upscale Bay Area retirement community, is grappling with a string of disturbing incidents involving residents, leading to calls for peace.
Arsenal star takes aim at Havertz-less Germany
Christos Tzolis helped Greece to a comeback win over Serbia and now turns his attention to Germany, who will be without Kai Havertz.Photo by Clive Rose/Getty ImagesChristos Tzolis is ready for Germany...
Tottenham's maximum possible Richarlison fee in January revealed
Richarlison in training for Tottenham, with Roberto De Zerbi in a circular inset
Netherlands XI vs Serbia – Predicted lineup and team news
On Sunday, the Netherlands will press ahead with their UEFA Nations League campaign as they travel to Belgrade to take on Serbia at the iconic Stadion Rajko Mitić.The Dutch side arrives in Serbia rid...
Serbia vs Netherlands – Match preview and team news
Netherlands will continue their UEFA Nations League journey on Sunday as they face Serbia in their next match away from home at the Stadion Rajko Mitić.Serbia vs Netherlands – Match preview and te...
Ireland's Controversial Nations League Fixtures: The Inescapable Connection Between Sport And Politics
On Sunday, the national men’s European football teams of Israel and the Republic of Ireland will face each other at a stadium in Hungary. A week later, they will meet once more, this time in Serbia. The very existence of these two games has created a lot of controversy, especially among Irish fans. Politics related […] The post Ireland’s Controversial Nations League Fixtures: The Inescapable Connection Between Sport And Politics appeared first on Stadium Rant.
Thunderbirds visit Monterey mental health facility to inspire youth
A U.S. Air Force Thunderbirds pilot and team members visited Ohana, a mental health facility in California, to share messages of teamwork, perseverance, and hope with young patients.
Claims China’s BeiDou satellite was refuelled in orbit could change space race
Research papers suggest the historic operation occurred in February last year, a manoeuvre that could have military implications.
Diamondbacks’ postseason push takes a turn with Gabriel Moreno update
SAN DIEGO — The Arizona Diamondbacks might be on a roll after their sixth straight win Friday, but eyes are now on catcher Gabriel Moreno after manager Torey Lovullo’s latest update. Sep 25, 2026; San Diego, California, USA; Arizona Diamondbacks catcher Gabriel Moreno (14) is congratulated by right fielder Corbin Carroll (7) after scoring during the first inning against the San Diego Padres at Petco Park.
Vanderbilt Health, TCAT Nashville celebrate medical assistants participating in new nursing pathway
Vanderbilt Health, in conjunction with The Tennessee College of Applied Technology Nashville, recently celebrated the first medical assistant to licensed practical nurse class.
Denny Hamlin Draws His Line With Carson Hocevar
Denny Hamlin says Carson Hocevar's off-track jabs are where NASCAR drivers and fans part ways. He also explained the one move that would set him off.
Pioneer of China NewCo model sued in US over trade secret misuse, double-dealing
A legal feud unfolding in New York is putting a spotlight on the work of a business development veteran who is credited for pioneering one of biopharma’s hottest dealmaking mechanism: the China “NewCo” model. In a lawsuit originally filed in New York state court and recently moved to federal court, China’s Lepu Medical Technology has alleged that biopharma business development consultant Su Zhang, who was hired to help shop its GLP-1 weight-loss candidates to Western partners, engaged in corporate double-dealing and trade secret leaks. According to the complaint, while acting as Lepu’s primary dealmaking liaison for a group of obesity and metabolic disease drug candidates, Zhang was secretly double-dipping as the acting chief business officer for a direct competitor, BrightGene Pharmaceutical. “She never adequately disclosed the role, never sought Lepu’s consent, and never proposed any safeguard,” Lepu alleged in its complaint, which was filed in July after Zhang’s consulting firm, CoDevCo, sought certain transaction-based success fees from its angry customer through an arbitration process in Singapore. Lepu, the parent company of Lepu Biopharma, has asked Zhang to pay back its $500,000 retainer and disgorge all benefits she received during the alleged breaches of fiduciary duty, plus other damages and relief. The company has also requested the court grant injunctions to protect Lepu’s trade secrets. The ill-fated partnership officially kicked off in December 2024, when Lepu tapped CoDevCo as its “exclusive business development mechanism” to identify collaborators for the company’s drug candidates. According to Lepu’s complaint, Zhang personally negotiated and signed the agreement as managing director for CoDevCo, which used her home address. Before the Lepu deal, Zhang made a name following a short stint as the global head of business development for Hengrui Pharmaceuticals. It was during her tenure that Hengrui signed a landmark deal granting exclusive rights for a portfolio of GLP-1 assets to Hercules, which was at that time newly established by a group of private equity and venture capital firms. In addition to the regular upfront and milestone payments, Hengrui also gained an equity stake in Hercules, which later became Kailera Therapeutics. The Hengrui-Hercules deal opened a new paradigm, where a Chinese biopharma company spins off certain early-stage assets to investors for further development through the creation of a new company abroad. The “NewCo” model quickly came into vogue as it allows Western investors to access high-potential assets originating from China at an early stage while giving the Chinese licensors an opportunity to reap long-term benefits through equity stakes in the new firms. The NewCo model proved its value when Kailera staged a record-breaking $625 million IPO on Nasdaq this April, merely two years into the Hengrui deal. Related Kailera CEO 'knew we were in a good spot' before obesity biotech's record-breaking $625M IPO On her LinkedIn page, Zhang described her work at Hengrui as “[b]uilding team and capability from the ground up,” forming NewCo and major pharma partnerships worth billions of dollars. Lepu clearly wanted that kind of track record to help boost its own cardiometabolic portfolio, which includes a range of assets for obesity, Type 2 diabetes, fatty liver disease and muscle preservation during weight loss treatment. “Lepu’s pipeline is very valuable, but only if Lepu could secure the right international partner to expand into the overseas market during the available commercial window,” the company argued in its complaint. The Chinese biotech said it had little knowledge of U.S. laws, customs or business practices in the business development field, and therefore “needed to rely entirely” on the expertise of Zhang and her team as the firm’s first engagement of a U.S.-based BD consultant. “Zhang’s dominating influence on the business development strategy is further evidenced by the fact that she personally controlled the business-development communications on behalf of Lepu with potential partners,” Lepu said in its complaint. After entering the deal, Zhang introduced Lepu to her four associates. According to Lepu’s version of events, all of them were allegedly employed at different time points to perform similar jobs at other Chinese companies that Lepu described as its competitors, while having access to Lepu’s confidential information. As such, Lepu described Zhang’s team as “a roster of individuals whose primary professional loyalty, by virtue of their concurrent full-time employment, ran to Lepu’s competitors.” As well as the specific examples set out in the case, a look at Lepu’s deals over the period suggests Zhang may have been involved in at least one transaction. During their partnership, Lepu, through its subsidiary Shanghai Minwei Biotechnology, also out-licensed its GLP-1/GIP/FGF21 agonist MWN105 to a NewCo called Sidera Bio in the fall of 2025. The deal included an upfront and near-term payment of $35 million, up to $1.01 billion in milestones, and a 9.99% stake in the Danish startup. It seems likely that Zhang facilitated the Minwei deal given that Lepu is on record as having used CoDevCo as its “exclusive business development mechanism.” The big shock for Lepu came in the form of a news article on June 25, 2025. The article, reporting on phase 2 data for BrightGene’s GLP-1/GIP receptor agonist BGM0504, identified Zhang as acting chief business officer of the Lepu rival. Blindsided by her association with BrightGene, Lepu confronted Zhang in July 2025. “Lepu was given assurances that there was nothing to be concerned about and told that Zhang would explain the matter to Lepu,” Lepu alleged in its complaint. “Zhang never did.” Lepu claimed that Zhang had the motive and opportunity to steer potential prospective partners toward BrightGene or other competitors. Later, in February 2026, one of Zhang’s associates joined BrightGene as the vice president for global business development, according to the complaint. Around the same time, Lepu sent written demand letters asking Zhang to account for her BrightGene role, identify what confidential data were shared with the rival firm, and provide any conflict-of-interest or firewall policies during the engagement. According to Lepu, neither CoDevCo nor Zhang answered the questions in their responses. Related Novo vs. KBP: How a $1.3B deal turned into a fraud accusation and an international legal fight In a motion to dismiss filed with the U.S. District Court in the Eastern District of New York on Sept. 4, Zhang’s legal team argued that Lepu’s agreement was signed with CoDevCo, and that an employee of the contractor does not owe fiduciary duties to the client. In its complaint, Lepu said: “That CoDevCo was the contracting entity does not insulate Zhang from personal liability for duties she personally undertook and personally breached.” Taking the argument one step further, the defending party argued that the consulting agreement “does not create a fiduciary relationship even between CoDevCo and Lepu; instead, it identifies CoDevCo as an independent contractor retained to market Lepu’s business to potential western partners.” Although CoDevCo was Lepu’s exclusive business-development contractor, there were no terms stipulating that the consulting firm should serve only Lepu, Zhang’s lawyer noted. As to Lepu’s claims that Zhang misappropriated trade secrets, the defendant argued that Lepu authorized the use of the information so Zhang’s team could perform their service per the agreement. In a rebuttal filed on Sept. 11, Lepu’s lawyer set out why they believe the Chinese biotech satisfied New York law’s misappropriation definition by alleging that the defendant used a trade secret “in breach of a duty or through improper means.” As an alternative to dismissing the suit, the defendant suggested the action should be stayed pending outcomes from the arbitration of a separate case in Singapore. While NewCo pioneer Zhang is defending her business arrangements, momentum behind the NewCo trend has continued unabated into 2026. Through August, Chinese biotech assets have spurred 15 NewCo deals this year, according to local trade publication PharmaDJ.
Darrell Waltrip’s NASCAR Career: Championships, Wins and Greatest Moments
From three Cup championships and 84 victories to a long second career with FOX Sports, Darrell Waltrip left his mark on nearly every corner of NASCAR.
Can Chase Elliott Turn Season Around at Kansas Speedway?
Chase Elliott hopes to turn season around at Kansas.
Reducing the $2T federal deficit could lower inflation, interest rates for Americans: CRFB
Curbing the federal government's roughly $2 trillion budget deficit could lower inflation and current interest rates for households, a CRFB report finds.
A key Republican defends Alaska Senate candidate Mary Peltola after reports of abusive behavior
Republican Sen. Dan Sullivan criticized his Democratic opponent Mary Peltola, a former congresswoman, over allegations of abusive behavior toward members of her staff, which he described as “very disturbing.”
A horse named 'Austrian Painter' with a disturbing backstory exposed a glaring problem in horse racing
The Jockey Club may need to overhaul its name-approval process after a controversial horse won a race.
Advanced Health Tech Research Continues to Protect Astronaut Health
Advanced health research, including ultrasound scans, blood tests, and exercise studies, using the latest technology in microgravity was on Thursday’s schedule for the Expedition 75 crew. The orbital residents also continued their ongoing cargo operations and maintenance tasks aboard the International Space Station.
Kevin Byram named Medical Director of the Vanderbilt Specialty Pharmacy
Kevin Byram, MD, Associate Professor of Medicine, has been named Medical Director of the Vanderbilt Specialty Pharmacy, effective Oct. 1.
NASCAR Legend Darrell Waltrip Reveals Serious Health Diagnosis
NASCAR Hall of Famer Darrell Waltrip and his family have shared a difficult health update, revealing the three-time Cup Series champion's diagnosis and why he will be stepping further away from public life.
Vita Coco's Cofounder Cracked Open The Coconut Water Business
No doubt about it, Michael Kirban knew introducing coconut water to America would be a tough nut to crack.
CJ Bailey discusses aftermath of Vanderbilt game
CJ Bailey met with the media yesterday, the first time he’d spoken with reporters since The Thing That Happened. There is no way to explain any part of what went down during The Thing That Happened, of course, but he did the best he could. Sometimes the football is snapped and major regret ensues. In […]
Durbin: Obama election 'one of the real satisfactions of my career'
Sen. Dick Durbin talks early losses, major wins, Barack Obama and ahead of his retirement.
Five Takeaways: Commercial Real Estate Market
For its latest episode of Elevating The Conversation, the Journal sat down with Alicia Barbieri, co-president of Goodale & Barbieri, to discuss the commercial real estate market.
Hands-on science can be cool
After spending many long days conducting experiments to find a new way to combat bacterial infections in crops, Misha Hegde and Mia Soleil Maurer have been rewarded with international recognition and access to top research facilities. But these are not typical scientists. They are 16-year-old German high school students.“Our supervisor told us that in order to start a project, you need to begin with either a question or a problem,” says Misha, adding that she and Mia had read about antibiotic resistance in certain plants being treated for bacterial infections. “We found out that antibiotics overuse is very common in agriculture,” explains Mia. “Our aim was to create an alternative to antibiotics and to try to raise awareness of the problem of overusing antibiotics.”Their subsequent research has focused on harnessing bacteriophages, the natural predators of bacteria, to eliminate pathogens threatening food crops treated with antibiotics. At the Schuldorf Bergstraße Jugend forscht MakerLab in Seeheim-Jugenheim, located in the German state of Hesse, they discovered a novel phage that infects the Rhizobium rhizogenes bacterium, which causes the hairy root disease that can reduce yields of tomatoes, carrots, soya beans and other food staples.The students believe their method could curb antibiotic use, while protecting plants from infections without disturbing the natural soil microbiome. “The application of phages is host-specific, so they would only kill the targeted pathogen or disease-causing bacteria,” explains Mia. It may also offer environmental benefits, since applying antibiotics can contaminate groundwater.Getting to this point has not been easy. The childhood friends admit to feeling frustrated when their trials did not yield the expected results. “We spent six months on our first experiment, just doing the same thing over and over and over again, to the point where we thought, is it even worth it? Why are we doing this?” Misha says. “You just need to be brave enough to take that first step and keep going.”The benefits of inquiry-based learningTheir determination has paid off. In 2025, the pair won first prize in biology at Jugend forscht, Germany’s national competition for young people interested in science, technology, engineering and mathematics. They were also among the winners of the German Research Foundation Europa-Preis, which is awarded to selected national winners at Jugend forscht, and took third place in the 2025 European Union Contest for Young Scientists.The Jugend forscht Foundation opens doors for young people to connect with scientists as well as industry professionals. Jessica Bönsch, executive director of the Foundation, sees Misha and Mia as prime examples of how young people can develop a deeper understanding of science through their own research projects. “The experience of working on your own research question is very important,” she explains, adding that “inquiry-based learning engages with real-life problems in a way that can be more motivating than traditional classroom teaching.”The Jugend forscht Foundation offers financial support through sponsor pools in Germany’s federal states. Some projects are developed in cooperation with student research centres, university labs or informal collaborative learning areas called makerspaces. Other activities start as hands-on “garage projects” and can grow within the Jugend forscht network and infrastructure.The Jugend forscht Foundation is also a partner of Science Comes to Town, an EU initiative to strengthen public awareness about science and create bridges between researchers and communities. The EU-financed project involves universities, research institutions and other stakeholders in three host cities — Brest (France), Kiel (Germany) and Split (Croatia).“It's so important for people not to live in a bubble, because I think science can be very scary if you misunderstand it,” Mia says of SCTT. The initiative’s aim of raising awareness about science is “absolutely amazing,” Misha adds. “I think it's the best way to kind of make science digestible for the public. In a world where misinformation in science is getting more radical, more dangerous, becoming more of a threat to the trust in scientific infrastructure and foundations, we need such programmes.”Misha and Mia also believe that SCTT can help break down gender stereotypes in science by encouraging young women to study and pursue careers in scientific fields. Both students have benefited from female mentors and encouragement they had when they were much younger. Mia’s love of science began with a class trip to a lab, while Misha — with a smile on her face — says she wanted to study history until “a teacher kind of coerced me into joining a school science club.”Recognition beyond EuropeIn May, Misha and Mia were among the finalists at the Regeneron International Science and Engineering Fair held in Phoenix, Arizona, and involving nearly 1,700 pre-university students from over 60 countries. “It was very crazy because there were so many people and so many teenagers interested in science,” Mia recalls. The event was also challenging. “It was eight hours of continuously presenting your project,” adds Misha.Attending the fair was a chance for the young women to see first-hand the value of international collaboration as well as how research cultures differ. “America is a bit more willing to take risks, and I think that's something we can learn about here in Europe,” Misha explains. However, she continues, “I think Europe has the talent, has the innovation and has the resources” to be competitive.Misha and Mia plan to continue their phage experiments in the new school year, inspired by the project’s hands-on nature and the support they receive from their supervisors. They have also attracted the interest of professional scientists and received invitations to leading research facilities, including the Centre for Synthetic Microbiology, jointly run by the University of Marburg and the Max Planck Institute for Terrestrial Microbiology in Germany. “It is so cool that we can do something to try to move the world in our school and at this age,” Mia says.After completing secondary school, Mia plans to study microbiology and pursue a career in medical research, focusing on Ebola and other infectious diseases. “This has been my dream for so long,” she says. Her friend Misha is interested in biological research with a focus on medicine. “I've gotten addicted to the process of going to the lab, planning out experiments, then failing, trying again,” Misha says. “I think there's just so much to be discovered, so much to be done.”The students' names and photos were published with the permission of their parents.Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.
N.C. State QB CJ Bailey takes positive approach after costly Vanderbilt fumble
The third-year starter says the team has showed him support to help him move forward for Saturday's visit from Appalachian State.
ENTERTAINMENT: ‘Barbie and Friends’ come to ESSE Museum; Laman library hosts wrestling
ESSE Museum & Store opens “Barbie and Friends” with a 5-8 p.m. Thursday opening reception that offers the opportunity to “meet two real live Barbies in person,” according to a news release.
Vanderbilt Health leaders advance a collaborative agenda to engineer the elimination of targeted diseases
Vanderbilt Health leaders are helping advance a national effort to move care upstream: from treating disease after it emerges to preventing, interrupting and ultimately eliminating targeted diseases.
Crew Studies Advanced Health Tech and Gears Up for Next Crew Swap
Ultrasound scans using augmented reality and artificial intelligence topped the health research schedule aboard the International Space Station on Wednesday. The Expedition 75 crew also collected blood and saliva samples to study how the immune system adapts to weightlessness. The orbital residents are now preparing for a crew swap as NASA’s SpaceX Crew-13 mission announces a launch date.
The Science Gap Fueling Africa’s Water Wars - USC Viterbi
In a new Nature Sustainability commentary, USC Viterbi researcher argues advanced water modeling can reduce uncertainty and help turn water disputes into opportunities for cooperation.
Vanderbilt Health study identifies drugs with potential to improve outcomes associated with preterm labor
A team of Vanderbilt Health investigators has identified drugs with previously unrecognized potential as treatments for preterm labor.
Navy All-American Bowl to honor tight end Korz Loken
The Navy All-American Bowl Road to the Dome tour will visit Thunderbird Field in Scandinavia, Wisconsin, on September 25th to recognize Korz Loken as a 2027 Navy All-American.
Science Applications International (SAIC) After ORBIT Launch Narrative Puts Valuation In Focus
Science Applications International (SAIC) has recently drawn investor attention after its shares closed at US$129.69. The move comes amid steady government IT contract activity and mixed short term price performance. Recent trading has been choppy, with the share price slipping 2.7% over the last day and 3.0% over the past week. However, Science Applications International still shows building momentum, reflected in a 19.6% three-month share price return and a 33.4% one-year total shareholder...
NASA’s Hubble Seeks Lensed Supernova, Marks 200,000 Orbits
NASA’s Hubble Space Telescope completed its 200,000th orbit around Earth on Sept. 19, marking another new milestone for an observatory that continues to
Denny Hamlin: Carson Hocevar Always Picks the ‘Nuclear Option’
With Ryan Blaney sitting across from him, Denny Hamlin broke down the Bristol wreck and said Carson Hocevar always reaches for the nuclear option. Hamlin also pointed to his own 2017 mistake at Martinsville as the reason he sees it…
Alec Burleson’s Gold Glove Case
When you think of Alec Burleson, you think of his power. His 23 home runs and 111 RBI have helped the St. Louis Cardinals exceed expectations this season. In fact, he currently leads MLB in RBI. Burleson's offensive resume already includes a Silver Slugger, earning it last year as a utility player. He is a …
'De Zerbi is in an impossible position'
Tottenham's Roberto de Zerbi as well as Xabi Alonso of Chelsea are in an "impossible position" this season, believes The Observer's Rory Smith. The managers took charge of their clubs in the spring and oversaw a lot of activity in the transfer window, with Chelsea and Spurs ending the summer as the second and third highest spenders respectively. Smith says the changes to their squads is why De Zerbi and Alonso need time to build coherence in their sides.
Ready for takeoff: Ken Maassen's classes and hands-on experiences helped prepare him for a career at Lockheed Martin
Maassen, who received a Bachelor of Science in mechanical engineering, helps integrate gas-turbine engines onto the aircraft.
Vanderbilt Health to lead nationwide initiative to improve outcomes for critically ill patients
Funded via ARPA-H, CIRCLE will combine advances in diagnostics and AI to speed development of next-generation interventions that identify and respond to harmful immunoinflammatory states before life-threatening complications occur.
Auburn Weekly Roundtable
Week 4 has arrived, and the Auburn Tigers are looking for a bounceback after their 42-39 loss to the Florida Gators. It’s Homecoming on the Plains, and the Vanderbilt Commodores are in town, who have had the Tigers’ number over the past few seasons.
In 2022, scientists unveiled a wind-turbine material that could be recycled into gummy-bear ingredients. Four years later, where did the idea go?
A viral scientific breakthrough promised to solve wind energy's waste problem—but the gummy bears were never the real goal, and the hype outpaced what the lab could actually deliver.
California, New York sue to block Trump deals canceling offshore wind projects
The lawsuit was filed Tuesday
California, New York sue to block Trump deals canceling offshore wind projects
The lawsuit was filed Tuesday
UF Health opens 99-bed Durbin Park hospital in St. Johns County
UF Health celebrated the opening of its Durbin Park campus on Sept. 17, expanding access to advanced medical care in one of Northeast Florida’s fastest-growing areas.
Spurs legend Hughton 'very confident things will improve'
Former Tottenham defender Chris Hughton says he is "very confident things will improve" under Roberto de Zerbi despite a poor start to the 2026-27 season. Sometimes it clicks straight away, sometimes it takes time.
Corbion launches second cultured preservation solution
The portfolio now includes Verdad Essence WH150.
Summer spending put Alonso in 'impossible position'
Chelsea's Xabi Alonso as well as Roberto de Zerbi of Tottenham are in an "impossible position" this season, believes The Observer's Rory Smith. The managers took charge of their clubs in the spring and oversaw a lot of activity in the transfer window, with Chelsea and Spurs ending the summer as the second and third-highest spenders respectively. Smith says the changes to their squads is why Alonso and De Zerbi need time to build coherence in their sides.
Is 50 the new 60?
Subscribe TL;DR: Younger generations are showing signs of worse health compared to earlier-born cohorts at the same age This backward “drift” is showing up both in mortality risk and chronic disease Worsening trends in obesity and diabetes are the most consistent signals Taking the long view, we’ve made astonishing gains in health and life expectancy in the last century. Global average life expectancy has more than doubled from 32 years in 1900 to 73 years in 2024. (But don’t forget, there were still old people when life expectancy was 32). As people lived longer, they also generally lived healthier along the way. It turns out that avoiding things that can kill you early, like malnutrition and lots of childhood infections, also keeps you healthier later in life. In a classic 2004 paper, Finch and Crimmins proposed that cohorts of children who benefited from fewer early life infections had less lifetime exposure to inflammation and cardiovascular disease later in life, accelerating mortality improvements at older ages. Poor nutrition in the womb has also been linked to a higher risk of later chronic disease. The upshot is that improvements in childhood health can pay dividends many decades later. The combination of better living conditions (nutrition, sanitation) and medical advances (antibiotics, vaccines, blood pressure meds, etc) meant that people’s healthy lifespan generally expanded, even as they lived longer. Aging researchers call this best-case scenario “compression of morbidity”—meaning we delay the onset of disease and disability even faster than the years of life we are adding. During my 20+ year research career, we could generally bank on the idea that younger generations would not only live longer but also keep getting healthier along the way. “60 is the new 50” as they say… Enter “Generational Health Drift” Sadly, this expectation of steady progress may be changing. You’ve probably heard that US life expectancy gains have slowed to a crawl in the past couple of decades. Mortality improvements are also slowing (though less dramatically) in many other high-income countries (you can read more about that in a review paper I wrote here). Mortality is a very blunt health measure, but it is often a good barometer for the broader population health trends happening underneath. And we are now seeing that younger generations may be in worse health at similar ages compared to earlier born cohorts. My collaborator Prof. George Ploubidis at University College London coined this worsening health in more recently born cohorts “generational health drift.” “Generational health drift” is bad news on multiple fronts. Most obviously, we don’t want our health progress to go backward. But the timing is also bad, since our populations are aging. In demographic terms, “population aging” means that the proportion of the population at older ages (i.e >65 years) is increasing. Fun demography fact: Current population aging is not due to the recent declines in the birth rates making the news, but declines in fertility decades ago, after the “baby boom.” As baby boomers reach older ages, the smaller cohorts behind them mean the percentage of older adults will increase. For example, the share of the population age 65 and older in the US increased from 12.4% in 2004 to 18.0% in 2024. This story of population aging was written long ago. Many worry that population aging will put pressure on health care and pension systems. But if people reach older ages in better health than in years past, those fiscal pressures would be less dire than projected. Healthy older people can also continue to contribute to society in many valuable ways, including paid work, caregiving, community service….even high political office 🤷. On the flip side, if younger generations reach retirement age in worse health and with more disabling conditions, this could magnify the societal challenge of population aging. Evidence for worsening generational health A recent paper that I LOVED in the Proceedings of the National Academy of Sciences by Dr. Leah Abrams and colleagues examined which birth cohorts (aka generations) were behind worsening US mortality. Behold the Lexis diagram (cue swooning demographers). Calendar time is on the x-axis, age on the y-axis. Birth cohorts can be followed over time as they age on the diagonal lines moving up and to the right. This figure plots the year-on-year % change in all-cause mortality at a given age. Green shading indicates mortality improvements over time, white is stagnation, and gray shading indicates worsening mortality. Following the diagonal line for those born in 1950, you can see a noticeable shift from green to gray that follows this cohort for most of their lives. This gray shading shows generally worsening mortality for the 1950 to 1959 birth cohorts compared to their predecessors across all ages. Concerningly for my GenX and elder millennial peeps, there was also a deterioration in mortality for birth cohorts born in the 1970s and 1980s, visible as dark gray areas at ages 30 to 45 during the 2010s. While some of these mortality changes reflect specific shocks such as the opioid epidemic, most deaths still occur from major causes of death such as cardiovascular disease and cancer. For cancer, the gray in the top left corner of the figure below reflects the legacies of smoking for older cohorts, followed by a period of green with improvements in cancer mortality as smoking rates declined. But the white/gray shading in the bottom right corner highlights a stagnation and reversal of the cancer trends, with cohorts born around 1970 to 1985 experiencing worsening cancer mortality. This deterioration was most noticeable for colon cancer mortality, possibly linked to obesity or dietary factors. Not just dying more, but less healthy along the way. A recent paper by Dr. Laura Gimeno of University College London (of which I am a co-author), found evidence that more recently born cohorts in Great Britain have stagnating or worsening health. A stylized picture of what“generational health drift” might look like: The review paper found: Rates of childhood overweight and obesity were highest among Gen Z. Rates of diabetes in the 40s almost doubled from 3.1% among the Baby Boomers to 5.9% in Generation X. Gen Z reported higher rates of poor mental health in adolescence compared to earlier-born groups. These UK results are consistent with studies showing worsening health across generations in the US as well. A 2021 US study found that more recently born cohorts had worse biological markers (like blood pressure and blood sugar) than earlier generations at the same age. A separate 2022 study of Americans aged 50 and over found that more recently born generations had a higher number of chronic diseases, with younger age of disease onset. A 2024 Lancet paper found that in the US, women born in 1945 had 33% obesity prevalence at age 50, rising to 48.2% for women born in 1970 turning 50. So what’s going on, and can we turn it around? We don’t have a definitive answer for what’s causing the deteriorating health of younger cohorts, but circumstantial evidence points to worsening trends in obesity and diabetes in both the US and UK. Remember that cohort trends reflect lagged effects of early environments, and younger generations have faced both earlier onset and more severe obesity across their lifetimes. Despite these very concerning trends, the future is not set in stone. We’ve reversed poor generational health trends before: drops in smoking are a major reason cancer and heart disease deaths fell so dramatically in recent decades. GLP-1 drugs may finally turn the tide against rising rates of obesity and diabetes, though it is still early days. But things could also get worse…for example from a return to higher levels of childhood infectious diseases that can have a lasting impact on health. See for example: [ ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) [ Don’t You Forget About Me(asles): The Virus That Erases Immune Memory ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) Jenn Dowd, PhD · March 24, 2025 [ Read full story ](https://jenndowd.substack.com/p/dont-you-forget-about-measles-the) Even as an optimist, emerging data on the “generational health drift” has my full attention. For most of my research career, we took it for granted that each generation would be healthier than the last. But if present trends continue, **50 could be the new 60….**and Gen Z celebrities will soon look older than Paul Rudd :). Stay well, Jenn Share the Health! If you found this post useful, please share it with a friend. Share
Is Roberto De Zerbi Misusing Mateus Fernandes For Tottenham?
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Voters cite political climate, economy and homelessness as Oregon governor race nears
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Mental Health Treatment by Adults in the United States
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Med Center Health 10K runners pounded the pavement Saturday
The Med Center Health 10K Classic, in its 47th year, was run Saturday , Sept. 19, 2026, at the Bowling Green Ballpark. The event featured a 10K wheelchair race, 10K race, 5K race and the Children’s Classic Run. Titus Winders won the men’s overall title with Corbin Harris coming in second and Wayne Blas third. Purity Sanga won the women’s overall title with Daisy Jepkosgei second and Rachel Tinius third. Matthew Porterfield won the wheelchair race with Matt Davis coming in second. Aerelle Jones won with 10K female wheelchair race. The top three male 5K winners were, in order, Lucas Page, Jay Beckner and Logan Rose. The top three female 5K winners were, in order, Sarah-Emily Woodward, Anna Cline and Autumn Tandy. (Joe Imel/Daily News)
Culturally Relevant Cardiovascular Disease Prevention and Care Strategies
(Feature Impact) Driven by rising rates of obesity, diabetes, high blood pressure and other risk factors, cardiovascular disease has surpassed cancer as the leading cause of death among Hispanic adults in the United States. googletag.cmd.push(function() { googletag.display('fixed-big-ad-top-asset'); }); Hispanic people represent nearly 1 in 5 of the U.S. population and are the nation’s largest ethnic minority group, yet many continue to face barriers to achieving heart health and accessing high-quality healthcare. A new scientific statement published in the American Heart Association’s flagship journal, “Circulation,” revealed how social, economic, cultural and environmental factors contribute to persistent disparities in cardiovascular health, calling for culturally tailored prevention strategies, equitable access to care and greater representation of Hispanic populations in cardiovascular research.“Hispanic populations in the U.S. are incredibly diverse even within their own communities with differences in genetic ancestry, language, cultural traditions and social experiences that can significantly influence cardiovascular health,” said Johanna Contreras, M.D., M.Sc., FAHA, director of the Division of Heart Failure and medical director of the Hispanic Heart Center within the Mount Sinai Health System. “Yet Hispanic people remain underrepresented overall in the research that guides prevention and treatment strategies… Without better representation and more detailed data, we risk overlooking important differences that can help us improve care and save lives.”Hispanic Cardiovascular Health by the NumbersCardiovascular risk factors – obesity (nearly 46%), type 2 diabetes (15.5%) and high blood pressure (approximately 44%) – are prevalent among Hispanic adults and often emerge at younger ages and occur more frequently among Hispanic adults compared with white adults.According to the report, only about 1 in 5 Hispanic adults achieves ideal cardiovascular health as defined by the American Heart Association’s original Life’s Simple 7 metrics. Updated analyses using the Life’s Essential 8 framework demonstrated persistent disparities for heart and brain health, as well as suboptimal dietary quality, sleep patterns and levels of physical activity.Social and Economic Barriers MatterBiology alone does not explain cardiovascular health disparities. The environments where people live, work and age, along with social and economic challenges, impact heart health. In fact, approximately 17% of Hispanics live below the federal poverty threshold, compared with 8.2% of white adults. googletag.cmd.push(function() { googletag.display('fixed-big-ad-middle-asset'); }); “Many Hispanic adults face obstacles that extend far beyond the doctor’s office,” Contreras said. “Limited health insurance coverage, language differences, food insecurity, environmental exposures and concerns related to immigration status can make it more difficult to prevent disease, manage chronic conditions and receive timely treatment.”Contreras emphasized the cultural values and practices of Hispanic people also influence how they perceive their health and healthcare options.“Family plays a central role in many Hispanic communities and can be an extraordinary source of strength, support and resilience,” Contreras said. “At the same time, family members are often called upon to translate medical information, navigate health systems and help make healthcare decisions for loved ones. Those responsibilities can shape how health information is understood and acted upon.”An Action Plan for Improving Hispanic HealthThere are practical opportunities to achieve equitable cardiovascular health and reduce disparities through community engagement, culturally responsive care, inclusive research and policies that address the underlying drivers of health.“Reducing cardiovascular disease among Hispanic populations demands action at every level,” Contreras said, “from improving access to culturally responsive care and expanding research participation to addressing the social and environmental conditions that shape health.”By addressing both medical risk factors and the social conditions that shape health, experts believe there is an important opportunity to reduce disparities and help more people live longer, healthier lives. Learn more at Heart.org.Photo courtesy of Shutterstock googletag.cmd.push(function() { googletag.display('fixed-big-ad-bottom-asset'); });
Culturally Relevant Cardiovascular Disease Prevention and Care Strategies
(Feature Impact) Driven by rising rates of obesity, diabetes, high blood pressure and other risk factors, cardiovascular disease has surpassed cancer as the leading cause of death among Hispanic adults in the United States.Hispanic people represent nearly 1 in 5 of the U.S. population and are the nation’s largest ethnic minority group, yet many continue to face barriers to achieving heart health and accessing high-quality healthcare. A new scientific statement published in the American Heart Association’s flagship journal, “Circulation,” revealed how social, economic, cultural and environmental factors contribute to persistent disparities in cardiovascular health, calling for culturally tailored prevention strategies, equitable access to care and greater representation of Hispanic populations in cardiovascular research.“Hispanic populations in the U.S. are incredibly diverse even within their own communities with differences in genetic ancestry, language, cultural traditions and social experiences that can significantly influence cardiovascular health,” said Johanna Contreras, M.D., M.Sc., FAHA, director of the Division of Heart Failure and medical director of the Hispanic Heart Center within the Mount Sinai Health System. “Yet Hispanic people remain underrepresented overall in the research that guides prevention and treatment strategies… Without better representation and more detailed data, we risk overlooking important differences that can help us improve care and save lives.”Hispanic Cardiovascular Health by the NumbersCardiovascular risk factors – obesity (nearly 46%), type 2 diabetes (15.5%) and high blood pressure (approximately 44%) – are prevalent among Hispanic adults and often emerge at younger ages and occur more frequently among Hispanic adults compared with white adults.According to the report, only about 1 in 5 Hispanic adults achieves ideal cardiovascular health as defined by the American Heart Association’s original Life’s Simple 7 metrics. Updated analyses using the Life’s Essential 8 framework demonstrated persistent disparities for heart and brain health, as well as suboptimal dietary quality, sleep patterns and levels of physical activity.Social and Economic Barriers MatterBiology alone does not explain cardiovascular health disparities. The environments where people live, work and age, along with social and economic challenges, impact heart health. In fact, approximately 17% of Hispanics live below the federal poverty threshold, compared with 8.2% of white adults.#placement_976606_0_i{width:100%;max-width:550px;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid976606 = window.pid976606 || rnd;var plc976606 = window.plc976606 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=976606;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid976606+';place='+(plc976606++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');“Many Hispanic adults face obstacles that extend far beyond the doctor’s office,” Contreras said. “Limited health insurance coverage, language differences, food insecurity, environmental exposures and concerns related to immigration status can make it more difficult to prevent disease, manage chronic conditions and receive timely treatment.”Contreras emphasized the cultural values and practices of Hispanic people also influence how they perceive their health and healthcare options.“Family plays a central role in many Hispanic communities and can be an extraordinary source of strength, support and resilience,” Contreras said. “At the same time, family members are often called upon to translate medical information, navigate health systems and help make healthcare decisions for loved ones. Those responsibilities can shape how health information is understood and acted upon.”An Action Plan for Improving Hispanic HealthThere are practical opportunities to achieve equitable cardiovascular health and reduce disparities through community engagement, culturally responsive care, inclusive research and policies that address the underlying drivers of health.“Reducing cardiovascular disease among Hispanic populations demands action at every level,” Contreras said, “from improving access to culturally responsive care and expanding research participation to addressing the social and environmental conditions that shape health.”By addressing both medical risk factors and the social conditions that shape health, experts believe there is an important opportunity to reduce disparities and help more people live longer, healthier lives. Learn more at Heart.org.Photo courtesy of Shutterstock
Porsche Faces Thousands More Job Cuts as Volkswagen Overhauls Its Business
Porsche could reportedly cut 4,100 jobs amid a profit warning. This comes amid Volkswagen’s larger plan to lay off 50,000 employees by 2030. Reuters quoted German outlet Handelsblatt, which stated that internal documents outlining Volkswagen’s newly approved restructuring plan, described…
Haaland completes Premier League set by scoring against Sunderland
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D-backs vs. Yankees discussion
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Vanderbilt stuns N.C. State with fumble recovery, improbable 35-31 win
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Inside Vanderbilt football vs NC State, Jared Curtis' first start
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Tottenham 2-3 Aston Villa: What De Zerbi said
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Yankees’ Gerrit Cole Sets All-Time MLB Record
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Scientists simulate cosmic crashes to test whether icy moons gain or lose their ability to sustain life
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Brentford 3-0 Chelsea: What Andrews and Schuster said
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De Zerbi insists Tonali is a ‘complete midfielder’
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Support from longtime Vanderbilt Health donor Herbert Christopher provides open access to new textbook co-created by otolaryngologist David Haynes
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Heavy caffeine users and deeper sleep; wonders of microscopic life; preparing for life after an Alzheimer’s diagnosis; plus other stories with Vanderbilt Health sources
Beth Malow, MD, Professor of Neurology and Pediatrics in the Vanderbilt Sleep Division, was quoted in Women’s Health about a surprising study from the Journal of Psychopharmacology indicating that heavy caffeine users get deeper non-rapid-eye-movement sleep, even while sleeping less time. The New York Times quoted Dylan Burnette, PhD, Associate Professor of Cell and Developmental Biology, in a story (with videos) about the wonders of the microscopic life all around us. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Prevention (rabies vaccinations); Healthline (update on the Cyclospora outbreak); Prevention again (hundreds now sickened in measles outbreak); and AARP (“How do we know vaccines are safe?” video interview and transcript). Science posted a story about a new NIH research center on vaccine harms. The piece quotes Kathryn Edwards, MD, Professor of Pediatrics, Emerita. Lealani Mae Acosta, MD, MPH, Associate Professor of Neurology, was quoted in an Everyday Health story about how a person, after a diagnosis of Alzheimer’s disease, can enrich their life and prepare for the future. Amalia Peterson, MD, Assistant Professor of Neurology, was quoted by Everyday Health in a piece about common medications linked to lower dementia risk.
Tottenham v Aston Villa: Key stats and talking points
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I Toured the Company Mapping Space Debris. Then I Polled Worried and Hopeful Scientists
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Gimme Him: Underrated Steelers LB could spark Patriots pass-rush
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Zelenskyy welcomes leaders from 7 countries for a regional summit
KYIV, Ukraine (AP) — Ukrainian President Volodymyr Zelenskyy hosted leaders and representatives from seven regional countries for talks on deepening cooperation on Friday, as overnight Russian strikes in multiple regions sparked fires and caused several deaths and injuries. The inaugural summit of the so-called “Carpathian Eight” brings together Ukraine, Romania, Serbia, Poland, Slovakia, the Czech […]
De Zerbi on trio's availability, 'staying calm' and Aston Villa
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Scientists hope deeper-rooted soybeans can withstand climate extremes and store more carbon
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How does De Zerbi fix Spurs' scoring troubles?
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EVS-4
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Vanderbilt Health transplants first HIV-positive organ into HIV-positive recipient
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Can researchers trust that AI models won’t leak their ideas?
Research funders are asking how they can stop confidential scientific ideas in grant proposals from leaking out through large language models (LLMs), for example if reviewers use AI to help them judge applications. Last week, a row erupted in mathematics after OpenAI announced it had solved a notoriously difficult problem, only for another mathematician to demand answers over whether the company had used ideas he had fed into its models. The spat, and the broader issue of idea leakage through AI models, was discussed by funders at an R&D policy conference held in Paris on September 14. At worst, it threatens to undermine the correct attribution of breakthroughs, one of the foundations of modern science. The mathematics dispute around OpenAI is “certainly something we're looking at” Jason Gallo, head of the newly established Office of Metascience at the US National Science Foundation (NSF), told the Blue Sky Forum, hosted by the Organisation for Economic Co-operation and Development. The controversy started on September 8, when OpenAI announced it had cracked a mathematical problem that had gone unsolved for 90 years. Using a swarm of AI agents, millions of dollars’ worth of computing power and a new internal model, the company said it had finally proved that a long-used formula for modelling fluid dynamics breaks down under certain conditions. However, Tristan Buckmaster, a New York University mathematician who had been independently working with collaborators on the same problem using OpenAI’s Codex tool, hit back with a statement questioning whether the company had snooped on his Codex sessions to gain an advantage. OpenAI has always denied it looked up the “specific user data” of Buckmaster and colleagues. However, the company initially admitted that “while unlikely, we cannot rule out that de-identified data derived from their usage of our products helped improve our models,” although its proofs “differ significantly” from Buckmaster’s. The firm later said that, following an investigation, it concluded that Buckmaster’s Codex prompts “could not have influenced the [OpenAI] system in any way, including through training.”Funder concernYet OpenAI’s initial admission that its model might have ingested Buckmaster’s ideas, then spat them out to its own mathematicians, has scientistsworriedthat their work could leak out if shared with AI. Some AI tools give users an opt-out option to stop their sessions from training the model. If such guarantees can be trusted, this gives scientists some confidence they can use an LLM to develop an idea without the risk of it leaking out.But there’s a bigger potential vulnerability. To win money to investigate ideas, scientists have to share them with funding bodies. These grant proposals are normally kept strictly confidential, to prevent other scientists from scooping them, or to protect commercially valuable intellectual property. To preserve this confidentiality, when the NSF uses AI models, “we have to be sure that it's not making server calls out to an external party, leaking that data,” said Gallo to delegates in Paris. Leaks through reviewersHowever, funders normally use external academic reviewers to assess proposals. And there are growing worries that these reviewers are feeding grant ideas into AI models to help them make a judgement. Research funders have noticed that peer review reports and funding recommendations have “suddenly become much longer, more detailed and complex,” said Diogo Machado, head of the data science unit at Technopolis, a science and technology-focused consultancy. “The sense is that reviewers are increasingly using generative AI in their review work, even where guidelines sometimes forbid it,” he told Science|Business. “This is very difficult for funders to control or prove.” Happening at scaleThis sharing of confidential proposals with AI models is “happening at scale already,” said James Wilson, executive director of the Research on Research Institute, based at University College London, during the debate in Paris. In response, Gallo said the NSF had “strict guidance” around the uploading of proposals to AI models. But he added the NSF was mulling new types of assessment to make sure applicants were truly the originators of their ideas, such as following a short-form proposal with an oral presentation, which would allow the foundation to “really interrogate the investigator on their intellectual contribution.” Related articlesHow can Europe cope with a flood of AI-assisted research grant proposals?The risks and benefits of AI in screening research grant proposals Viewpoint: AI could make scientific overload worse“For us as funders, a lot of the ways to ensure that the application remains the applicant's own intellectual contribution, those ways are quite regressive,” Peter Clifford, head of strategy at Research Ireland, told delegates. “They're maybe ten or 15 or 20 years old, and they don't scale particularly well.” Disputes over the origin of ideas are as old as modern science. Isaac Newton and Gottfried Wilhelm Leibniz spent more than a decade arguing over who invented calculus, for example. And long before LLMs emerged, academics would agonise over how much of their early work to reveal at conferences, in case their colleagues scooped them, Jack Leahy, a senior metascience advisor to the UK government, told delegates. But AI was “accelerating” the “problems of the system,” he said.
Jürgen Klopp’s full 44-player Germany National Team squad
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The Athletic reveals Texas A&M's exorbitant 2026 roster spending
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