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How Cassidy’s loss could turn into an even bigger win for RFK Jr.

Sen. Roger Marshall, a Make America Healthy Again devotee, is angling to replace the defeated Louisiana senator atop the Health Committee.

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May 17 • 2:26 PM EDT • Politics • politico.com
How Cassidy’s loss could turn into an even bigger win for RFK Jr.

Sen. Roger Marshall, a Make America Healthy Again devotee, is angling to replace the defeated Louisiana senator atop the Health Committee.

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May 17 • 2:26 PM EDT • Health • politico.com
Scientists Decode Giant Venus Cloud, Say "Hydraulic Jump" Is Behind It

This happens when a fast-moving, shallow flow suddenly slows down and becomes deeper.

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May 16 • 12:33 PM EDT • Science • ndtv.com
‘There’s science happening all around us’

MARSHALL — As another school year approaching the end, more than 900 area students and participants went on a field trip and made memories at the 2026 Science and Nature Conference on Tuesday at Southwest Minnesota State University, hosted by the Southwest West Central Service Cooperative (SWWC). This was the SWWC’s 32nd annual Science and […]

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May 14 • 8:00 PM EDT • Science • marshallindependent.com
Kara Wildman receives 2026 Woman in Business Award

Kara Wildman, owner of Happy Tails in Marshalltown, was presented the 2026 Woman in Business Award during the Marshalltown Area Chamber of Commerce Women in Business Luncheon held at Iowa Valley Business & Community Solutions Dejardin Hall on Thursday, May 14. Presenting Kara with the award was Stella and Jonas Wildman, Kara’s children. It was […]

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May 14 • 8:00 PM EDT • Business • timesrepublican.com
Lawmakers & Trump Admin. Officials Discuss The Advancement of Health Care

Lawmakers and top Trump Administration officials, including Sen. Roger Marshall (R-KS) and Centers for Medicare & Medicaid Services (CMS) Administrator Dr. Mehmet Oz, participate in discussions on U.S. advancement in health care.

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May 13 • 2:00 PM EDT • Health • c-span.org
Colorado ethics panel finds probable cause in complaint against Democrat caucus leader

The colleagues of a Democrat unanimously concluded they have probable cause to believe she committed an ethical violation by mismanaging her party caucus’s funds as its co-chair. The House Ethics Committee was charged with examining a complaint from Rep. Marshall, D-Highlands Ranch, alleging that Rep. Mandy Lindsay, D-Aurora, mishandled and improperly used caucus funds for […]

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May 11 • 4:02 PM EDT • Politics • coloradopolitics.com
Color Off the Mid-Atlantic Coast

Something is brewing in shallow waters offshore of Delaware, New Jersey, Maryland, and Virginia.

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May 11 • 12:01 AM EDT • Science • science.nasa.gov
2026 National Defense Science and Engineering Graduate (NDSEG) Fellowship Award

First year Materials and Nanoscience graduate student Stéphane Miaule (Tolbert group) has been awarded the 2026 National Defense Science and Engineering Graduate (NDSEG) Fellowship, one of the country’s most prestigious honors for graduate students in the fields of Science, Technology, Engineering and Math (STEM). The program, jointly sponsored by the U.S. Army, Navy, and Air Force, supports doctoral students across a broad range of scientific and technological fields of strategic importance. This highly competitive fellowship provides full tuition, fees, and a monthly stipend for three years. In 2026, only 102 fellowships were awarded nationwide, and Stéphane is the sole recipient from UCLA. Before transferring from Santa Monica College to UCLA, Stéphane interned at NASA’s Kennedy Space Center and Marshall Space Flight Center, where he researched the mechanical and thermodynamic properties of lunar regolith, as well as radiation shielding materials for lunar habitation development. At UCLA, he joined the Soft Materials Research Laboratory under Professor Qibing Pei, focusing on the synthesis and characterization of hafnium oxide nanocomposite scintillators. After earning his bachelor’s degree in chemistry, he remained in the Soft Materials Research Laboratory as a post-baccalaureate researcher for one year before joining Professor Sarah Tolbert’s group as a Ph.D. student. Stéphane’s Ph.D. research is focused on improving the properties of conjugated polymers, which are a family of plastic materials that can conduct electricity. Stéphane is specifically looking at self-assembling polymers that can be processed in water to create light-weight, flexible, high-conductivity polymer devices without the need for toxic or volatile organic solvents. After completing his Ph.D., Stéphane hopes to work in a national laboratory, researching semiconducting polymers for applications in new electronic devices. “The Graduate (1967) featured a memorable scene in which the protagonist was told that ‘there’s a great future in plastics.’ We know this still holds true today, as polymer research has expanded rapidly due to the wide variety of applications these materials enable. Through my work on semiconducting polymers, I hope to contribute to the continued development of plastic electronics,” Stéphane said. Penny Jennings, UCLA Department of Chemistry & Biochemistry, penjen@g.ucla.edu.

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May 8 • 1:21 PM EDT • Science • chemistry.ucla.edu
Small business relief has come, but more is needed, Sen. Marshall says

Kansas Sen. Roger Marshall calls attention to tax breaks and reduced regulation; advocates for competition on credit card swipe fees.

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May 6 • 6:04 AM EDT • Business • kansas.com
Restaurant proposed for Marshall. Some say prioritize pre-Helene ones

Anthony Willis said the Bojangles in Mars Hill, which he has owned since 2015, has only helped bring business to local eateries such as Wagon Wheel.

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May 4 • 5:02 AM EDT • Business • citizen-times.com
Marshall Athletics, Marshall Health Network Announce All-Sport Jersey Patch Partnership Through Learfield

Marshall Athletics and Marshall Health Network have announced a five-year partnership through Learfield that will provide an all-sport jersey patch on every ...

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May 1 • 4:10 AM EDT • Health • herdzone.com
Marshall Athletics, Marshall Health Network Announce All-Sport Jersey Patch Partnership Through Learfield

Marshall Athletics and Marshall Health Network have announced a five-year partnership through Learfield that will provide an all-sport jersey patch on every ...

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May 1 • 4:10 AM EDT • Sports • herdzone.com
Entertainment this week: Wild and Scenic Film Fest, Cushing Crossing and more

Friday, May 1 Coloso – 8 p.m.-12 a.m., Crystal Bay Casino, 14 Highway 28. Roots For The Depths Benefit Feat: COLOSO For more information, visit https://www.bandsintown.com/e/1038305529?app_id=pkvts0on0m&came_from=287&utm_medium=api&utm_source=partner_api&utm_campaign=event or call (775) 833-6333. Jeshua Marshall and The Flood...

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Apr 30 • 10:07 AM EDT • Entertainment • sierrasun.com
Democratic candidate for U.S. Senate touts business background, integrity in fight for Kansas seat

Sandy Spidel Neumann is running to take Sen. Roger Marshall's seat, focusing on the need for accountability in politics.

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Apr 27 • 10:00 AM EDT • Business • kansasreflector.com
B Marshall’s Draft Bash sees minority-business owners soldier through permitting issues

In the shadow of a behemoth commercial event raking in millions while christening new millionaires from a grand stage, on Friday afternoon, a group of 40 minority business owners was just looking to make ends meet in a relatively empty nearby North Side park. The picturesque scene at day two

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Apr 24 • 5:01 PM EDT • Business • triblive.com
Marshall Health Network enrolling patients in lung cancer clinical trial evaluating personalized immunotherapy approach

lungllulungHUNTINGTON, W.Va. – The Edwards Cancer Institute at Marshall Health Network (MHN) is enrolling eligible patients in a clinical trial evaluating whether a personalized immunotherapy approach can enhance the effectiveness of treatment following lung cancer surgery. The study is investigating the use of an individualized therapy designed with a tumor’s unique biology from a surgical sample to help the immune system better […]

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Apr 23 • 11:14 PM EDT • Health • news.marshallhealth.org
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The Symbolic Politics of Status in the MAGA Movement -

The Symbolic Politics of Status in the MAGA Movement By Biko Koenig, Franklin & Marshall College and Tali Mendelberg, Princeton University Drawing on ethnographic fieldwork among Make America Great Again (MAGA) activists during the 2020 [...]

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Apr 22 • 10:00 AM EDT • Politics • politicalsciencenow.com
Pufferbilly Days Festival Committee Announces Theme, Entertainment, and Grand Marshalls for 50th Anniversary

Boone, IA – April 20, 2026 – The Pufferbilly Days Festival Committee is thrilled to unveil the exciting lineup of events and entertainment scheduled for the 50th Anniversary of Pufferb…

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Apr 20 • 3:54 PM EDT • Entertainment • kwbg.com
Shallow surface waves in a giant tank

OIST PhD student Aditya Singh generates and observes surface waves that act as a classical analogue to quantum effects.

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Apr 20 • 5:21 AM EDT • Science • eurekalert.org
More Cities Sending Mental Health Workers Instead of Police to 911 Calls

More than 40 of the largest U.S. cities have launched some alternative response, but questions remain about how to pay for it.

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Apr 18 • 12:00 PM EDT • Health • themarshallproject.org
Fixing the 'mess' that is college sports compensation

College teams are throwing open transfer portals for basketball and football to welcome new players

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Apr 18 • 6:01 AM EDT • Sports • naplesnews.com
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Chicago IP firm Marshall Gerstein names first new managing partner in 24 years

The election of Randall Rueth comes amid an explosion in the field of patent law and as artificial intelligence transforms the legal industry.

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Apr 16 • 6:50 AM EDT • Business • chicagobusiness.com
Community, business leaders learn about economic growth during annual breakfast

There are many pieces in the healthy economy puzzle. Iowa Economic Development Authority (IEDA) Director Debi Durham spoke at the Marshalltown Area Chamber of Commerce Economic Outlook Breakfast on Wednesday morning and shared what should be done to help foster growth in local economies. Chamber President/CEO John Hall sat on the stage with Durham at […]

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Apr 15 • 8:00 PM EDT • Business • timesrepublican.com
After falling during hurdles, Beckham Borquez shall rise again

Sherman Oaks Notre Dame hurdler Beckham Borquez fell while competing in hurdles at the Arcadia Invitational, but he is planning an immediate comeback.

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Apr 13 • 7:00 AM EDT • Sports • latimes.com
LA Festival of Movies returns this weekend

LAFM founders Sarah Winshall and Micah Gottlieb preview this year's festival lineup

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Apr 8 • 6:25 PM EDT • Entertainment • spectrumnews1.com
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Roger Marshall visits Topeka to talk with NFIB, small business owners

Senator Roger Marshall met with Kansas small business owners to discuss health care costs, tax cuts and regulations.

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Apr 8 • 5:06 AM EDT • Business • cjonline.com
Marshall Health Network, The Opportunity Company to host senior health fair on April 17

WAYNE, W.Va. — The Opportunity Company and Marshall Health Network will co-host a complimentary health fair for senior adults from 10 a.m. to 1 p.m. on April 17, 2026, at the Wayne Senior Center, 40 Bridge St. in Wayne. The free event is designed to support the health and wellness of local seniors, offering a range of screenings and educational opportunities. Attendees can visit multiple […]

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Apr 7 • 1:33 PM EDT • Health • news.marshallhealth.org
Inside Huntington’s growing music & entertainment scene

Within the past decade, Huntington has drastically improved its music and entertainment scene. Growth of live music locales like The Loud, 9th Street Live and summer concert series provide exposure and experience to local artists. This change has opened new doors for Huntington musicians, especially Marshall students looking to launch a music career. One live...

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Apr 7 • 8:00 AM EDT • Entertainment • marshallparthenon.com
'The Music Man' Marches Into Eisenhower Auditorium

“Ya Got Trouble” in Happy Valley as Big League Productions’ national tour of Meredith Willson’s “The Music Man” comes to Penn State’s Eisenhower

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Apr 5 • 12:15 AM EDT • Entertainment • statecollege.com
2026 Best & Brightest Business Major: Ty Keough, USC (Marshall)

Ty Keough, a 2026 graduate of USC Marshall, has been named a Poets&Quants Best & Brightest Business Major of 2026

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Apr 3 • 12:25 PM EDT • Business • poetsandquantsforundergrads.com
Strange “elephant skin” rocks reveal ancient life in the dark ocean

A puzzling wrinkled rock formation in Morocco has led scientists to rethink where ancient microbes could live. Instead of shallow, sunlit waters, these microbes may have thrived deep in the ocean, fueled by chemicals delivered by underwater landslides. The discovery suggests that dark, nutrient-rich environments hosted thriving ecosystems much earlier than expected. It also raises the possibility that many similar fossils have been overlooked or misinterpreted.

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Apr 2 • 8:00 PM EDT • Science • sciencedaily.com
Sen. Marshall meets Kansas small business owners on key issues

TOPEKA (KSNT) – Small business owners from across Kansas met April 1, with Senator Roger Marshall and the National Federation of Independent Business to discuss the issues they say are puttin…

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Apr 1 • 11:47 PM EDT • Business • ksnt.com
Sen. Marshall meets Kansas small business owners on key issues

TOPEKA (KSNT) – Small business owners from across Kansas met April 1, with Senator Roger Marshall and the National Federation of Independent Business to discuss the issues they say are putting the mos...

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Apr 1 • 11:47 PM EDT • Business • yahoo.com
Kansas business owners voice concerns over insurance costs at senator’s roundtable

Sen. Roger Marshall met with a group of Kansas small business owners Wednesday.

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Apr 1 • 9:10 PM EDT • Business • wibw.com
Green Room Theatre at F&M to undergo renovations, become James Lapine Theater

The Franklin & Marshall College stage that once held performances by famous alumni, from actor Roy Scheider of “Jaws” to the late Oscar-winning director Franklin Schaffner, will earn a new

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Apr 1 • 5:00 AM EDT • Entertainment • lancasteronline.com
How squid survived Earth’s biggest extinction and took over the oceans

Scientists have finally cracked a long-standing mystery about squid and cuttlefish evolution by analyzing newly sequenced genomes alongside global datasets. The research reveals that these bizarre, intelligent creatures likely originated deep in the ocean over 100 million years ago, surviving mass extinction events by retreating into oxygen-rich deep-sea refuges. For millions of years, their evolution barely changed—until a dramatic post-extinction boom sparked rapid diversification as they moved into new shallow-water habitats.

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Mar 31 • 8:00 PM EDT • Science • sciencedaily.com
Pittsburgh black-owned businesses express frustration over NFL draft selection process

B. Marshall, Juneteenth promoter, said, "They are contracting businesses to work for the NFL to do certain functions."

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Mar 30 • 5:45 PM EDT • Business • wtae.com
Business briefs: New businesses coming to NKY - Marshalls, Fruit Land, Penn Station

Staff report Marshalls to open in Cold Spring Pointe Marshalls, one of the nation’s leading off-price retailers with over 1,200 stores currently operating in 48 states, D.C., and Puerto Rico, will open at Cold Spring Pointe on April 9. Shoppers in Cold Spring will find an amazing selection of high-quality merchandise across fashion, accessories, shoes,...

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Mar 29 • 12:34 AM EDT • Business • nkytribune.com
Campaign hopes to boost business at Marshall restaurants impacted by water outage

A shop local campaign aims to help Marshall restaurants that were forced to shut down during the recent water main break and boil water notice. The city of Marshall, Marshall […]

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Mar 26 • 6:40 AM EDT • Business • marshallnewsmessenger.com
TDN Business Hour: The Global Thoroughbred Market

Mark Taylor, Marshall Gramm, Anthony Trimarchi and Case Clay join the TDN Business Hour podcast hosted by Najja Thompson.

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Mar 24 • 2:43 PM EDT • Business • thoroughbreddailynews.com
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Madison County considers rezoning along scenic byway near Marshall

Lonesome Mountain Market owner Johnny Moore purchased the building in 2022 with the purpose of operating a general/convenience store, he said.

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Mar 18 • 5:01 AM EDT • Business • citizen-times.com
Family Science Fun Day at MU to bring hands-on STEM activities to community

HUNTINGTON, W.Va. — Families are invited to explore science together during Family Science Fun Day, a free, public event on Marshall University’s Huntington campus. The event will be held in […]

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Mar 16 • 12:00 AM EDT • Science • irontontribune.com
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Flooding closes roads in Marshall County, hurting business and raising detour concerns

Tuesday's storms are still causing issues in our area.Flooding across Marshall County is causing issues for people trying to get to their destinations as well a

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Mar 12 • 4:34 PM EDT • Business • wsbt.com
Colorado committee recommends rejecting alcohol, marijuana tax hike to fund mental health care

In a rare move, Colorado’s Capital Development Committee unanimously recommended that another legislative committee reject a bill asking voters to approve higher excise taxes on alcohol and marijuana to fund a new mental health hospital in Aurora. Sponsored by Rep. Bob Marshall, D-Highlands Ranch, and Sen. Judy Amabile, D-Boulder, House Bill 1301 proposes that all […]

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Mar 12 • 2:55 PM EDT • Politics • coloradopolitics.com
Marshall sued over plans to drop women's swimming and diving

More than a dozen members of the Marshall University women's swimming and diving team have filed a lawsuit over plans by the school to drop the sport.

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Mar 10 • 6:06 PM EDT • Sports • espn.com
Steven Roth sells former Queens department store to Northwell Health for $236M

Two of New York’s frequent real estate shoppers just made a $236 million deal on an abandoned department store in Queens.The seller was Steven Roth, who acquired the 340,000-square-foot retail property in 1995 after a battle for control with now-President Donald Trump. Roth and partners stand to reap a nearly $150 million gain from selling the building near the Long Island Expressway to Northwell Health. The deal was disclosed Monday by Alexander’s Inc., a real estate firm Roth runs that is named after the big-in-its-time department store that once operated in the building. Alexander’s filed for bankruptcy in 1992 and closed all 11 of its locations. The site later became a Sears. It has been vacant since Burlington and Marshalls moved out last year.

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Mar 9 • 2:23 PM EDT • Health • crainsnewyork.com
Scientists stunned to find signs of ancient life in a place no one expected

While exploring ancient seabeds in Morocco, scientists discovered strange wrinkle-like textures in deep-water sediments that shouldn’t have been there. These structures are usually made by sunlight-loving microbial mats in shallow waters. But the rocks formed far below the reach of light, suggesting a different explanation. Evidence points to chemosynthetic microbes—organisms powered by chemical reactions—creating the mats in the dark depths of an ancient ocean.

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Mar 8 • 8:00 AM EDT • Science • sciencedaily.com
Commentary: IC does not adequately support club sports

The memories, lessons and love that softball has brought me have proven invaluable, and that is something worth protecting. This institution does not give us money and actively impedes on our ability to play and practice. Access to Kostrinsky Field, even for just one day across a semester, would be a game-changer.

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Mar 5 • 11:33 AM EST • Sports • theithacan.org
Photo gallery: John Marshall defeats Fairmont Senior, 47-30 in Class AAA Region I final

MOUNDSVILLE, W.Va. — Photo gallery from John Marshall’s 47-30 win over Fairmont Senior in the Class AAA Region I co-finals. (Photo gallery courtesy of Robert Ovies Sports Photography)

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Mar 4 • 11:28 PM EST • Sports • wvmetronews.com
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Small Business Deduction Champion Award Presented to Sen. Roger “Doc” Marshall

NFIB presented the award to members of Congress who played a crucial role in making the 20% Small Business Deduction permanent.

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Mar 3 • 3:34 PM EST • Business • nfib.com
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How prison staffing shortages are driving away mental health staff

Correctional officers are leaving their jobs at federal prisons. And when these prisons are understaffed – psychologists and other staff are asked to act as guards. Recent reporting from The Marshall Project says it’s pushing mental health professionals out of prisons. For sponsor-free episodes of Consider This, sign up for Consider This+ via Apple Podcasts or at plus.npr.org. Email us at considerthis@npr.org.This episode was produced by Jason Fuller and Karen Zamora, with audio engineering by Ted Mebane.It was edited by Jeanette Woods and Courtney Dorning.Our executive producer is Sami Yenigun.

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Feb 25 • 6:25 PM EST • Health • npr.org
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Marshall scores 23, Morehead State downs Eastern Illinois 73-70

CHARLESTON, Ill. (AP) George Marshall scored 23 points as Morehead State beat Eastern Illinois 73-70 on Thursday.

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Feb 19 • 11:35 PM EST • Sports • cbssports.com
Scientists uncover oxygen-loving ancestor of all complex life

For decades, scientists have believed that complex life began when two very different microbes joined forces, eventually giving rise to plants, animals, and fungi. But one major puzzle remained: how could these organisms have met if one depended on oxygen and the other supposedly lived without it? New research suggests the answer lies in ancient microbes called Asgard archaea.

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Feb 19 • 7:00 PM EST • Science • sciencedaily.com
Marshall women’s swimmers compete as team is cut: ‘They are devastated’

Swimmers and divers were blindsided by the decision, which takes effect after this weekend's championships. Marshall will add a STUNT team.

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Feb 19 • 2:03 PM EST • Sports • nytimes.com
Former MHS business instructor pleads guilty to embezzlement from teachers union

A former Marshalltown High School (MHS) business instructor who was arrested last year for embezzling over $10,000 from the Marshalltown Education Association (MEA) has agreed to plead guilty to a single count of felony first-degree theft as she was originally charged, according to court records. Prosecutors in the case have recommended that Rachel Nelson-Loupee, 49, […]

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Feb 16 • 7:00 PM EST • Business • timesrepublican.com
Marshall County Schools join national lawsuit alleging social media harms mental health

Marshall County Schools joined a national class action lawsuit targeting social media companies recently saying it's affecting children's mental health.Board me

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Feb 16 • 5:09 PM EST • Health • wtov9.com
WSAZ Sports+| From the basketball court to Milan Cortina

Keith Morehouse and Joseph Payton are covering everything in the sports world from Marshall basketball to the Winter Olympics.

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Feb 11 • 4:08 PM EST • Sports • wsaz.com
'Be HER' Event Celebrates Women In Sports On Friday, Feb. 13

Marshall Athletics is excited to host the 'Be HER' event, starting at 6 p.m. on Feb. 13 in the Dutch Miller Deck of Joan C. Edwards Stadium. Presented by Bul...

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Feb 11 • 10:05 AM EST • Sports • herdzone.com
Building Her Business While Earning Her Degrees

Makenzie is building a real estate business while earning dual degrees in marketing and management at Marshall University. Learn how hometown roots, faith and entrepreneurial drive shaped her journey.

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Feb 11 • 9:34 AM EST • Business • marshall.edu
How — and why — to keep politics out of the office

Never assume that your work colleague shares your opinions on politics, our guest columnist writes along with seven golden rules for keeping the workplace conflict-free.

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Feb 9 • 9:56 AM EST • Politics • mainebiz.biz
Dolphins add former second-round pick to wide receiver room

Terrace Marshall Jr. brings size and potential to the Miami Dolphins’ WR room.

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Feb 4 • 10:26 AM EST • Sports • thephinsider.com
Marshall Health uses remote care to help employees achieve weight loss goals

By pairing medication therapy with consistent, telemedicine-enabled clinical oversight and care management support, the health system's program tackles the behavioral and lifestyle components necessary for success.

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Feb 2 • 1:12 PM EST • Health • healthcareitnews.com
Iowa politics: Proposal would require all Iowa police officers to cooperate with ICE

House File 2041 says local and state agencies "shall cooperate and work with United States immigration and Customs Enforcement and any other federal immigration-related agencies when requested.”

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Jan 26 • 1:52 PM EST • Politics • kcci.com
Herd Hospitality and Entertainment launched in effort to create additional revenue streams for Marshall athletics

Marshall officials are looking for enhanced opportunities to utilize athletic venues for an array of experiences, including concerts, weddings, meetings and other special events.

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Jan 26 • 1:50 PM EST • Entertainment • wvmetronews.com
Marshall Athletics Launches ‘Herd Hospitality & Entertainment’

Marshall Athletics has announced the official launch of 'Herd Hospitality & Entertainment' - a newly-structured department focused on unifying revenue genera...

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Jan 22 • 4:30 AM EST • Entertainment • herdzone.com
Buffalo Bills head coach candidates: Josh Allen drives profile

With Allen as the priority, Joe Brady, Brian Daboll and Davis Webb are among the early names to watch.

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Jan 21 • 6:00 AM EST • Sports • cbssports.com
Why do Alabama schools need Commandments our politicians don’t follow?

Blessed are the hypocrites, for they shall inherit the Education Policy Committee.

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Jan 20 • 7:30 AM EST • Politics • al.com
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Political Science Major Reflects on Impactful Experience at Thurgood Marshall Institute

Political Science Major Reflects on Impactful Experience at Thurgood Marshall Institute - Read this story on www.coloradocollege.edu

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Jan 16 • 7:00 PM EST • Science • coloradocollege.edu
Gov. Stein to discuss rural health improvements at virtual town hall

Governor Josh Stein, along with other state officials, will host a virtual town hall on Friday, Jan. 16, to discuss North Carolina's Rural Health Transformation

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Jan 15 • 8:57 PM EST • Health • wlos.com
Photo gallery: John Marshall defeats Linsly, 66-35

MOUNDSVILLE, W.Va. — Photo gallery from John Marshall’s 66-35 win over Linsly. (Photo gallery courtesy of Robert Ovies Sports Photography)

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Jan 15 • 8:07 AM EST • Sports • wvmetronews.com
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Attempt to affirm climate science fails on Senate floor

Republican Sen. Roger Marshall objected to a Democratic resolution.

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Jan 14 • 6:44 AM EST • Science • eenews.net
Powell's Made This Political: Sen. Marshall

Senator Roger Marshall (R-KS) shares his thoughts on the DOJ serving the Federal Reserve with subpoenas and whether or not he agrees with some of his GOP colleagues who will oppose any Federal Reserve nominations with this going on. Senator Marshall voices his support for President Trump's credit card interest rate cap proposal and discusses what's next on health care from the Senate. He speaks with Joe Mathieu and Julie Fine on the late edition of Bloomberg's "Balance of Power." (Source: Bloomberg)

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Jan 12 • 6:33 PM EST • Politics • bloomberg.com
And The Award Goes To…

Let’s Focus on the Positives, Shall We?

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Jan 10 • 11:49 AM EST • Sports • dailynorseman.com
Cancer-stricken 'Stranger Things' star Jennifer Marshall says Season...
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Jan 7 • 7:03 PM EST • Health • nypost.com
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NC Secretary of State calls for new budget to keep up with business registrations

New business formations reached record pace in North Carolina in the second half of 2025. Elaine Marshall says her team needs more staff to handle all the paperwork.

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Jan 6 • 5:11 PM EST • Business • wunc.org
Something hidden deep underground supercharged this Chile earthquake

A powerful 7.4-magnitude earthquake struck northern Chile in July 2024—and it wasn’t supposed to be that strong. Unlike Chile’s infamous shallow “megathrust” quakes, this one ruptured deep inside the Earth, where shaking is usually weaker at the surface. Researchers discovered that the quake broke long-held assumptions by tearing through hotter rock layers than expected, fueled by a rare chain reaction that accelerated the rupture.

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Jan 1 • 7:00 AM EST • Science • sciencedaily.com
The top Charlotte business stories of 2025

Before we get too far into the new year, let’s take a brief moment to look back — this time at some of the top Charlotte-area business news of 2025. To do that, Tony Mecia of the Charlotte Ledger Business Newsletter joined our Marshall Terry for our segment BizWorthy.

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Jan 1 • 3:00 AM EST • Business • wfae.org
College football bowl and 2025-26 CFP picks, predictions: Legendary Vegas expert reveals best bets today

SportsLine expert Bruce Marshall reveals betting guide for every College Football Playoff and bowl game

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Dec 31, 2025 • 10:02 AM EST • Sports • cbssports.com
Mission Health announces visitor restrictions, citing high rate of flu in WNC

WLOS News 13 provides local news, weather forecasts, traffic updates, notices of events and items of interest in the community, sports and entertainment programming for Asheville, NC and nearby towns and communities in Western North Carolina and the Upstate of South Carolina, including the counties of Buncombe, Henderson, Rutherford, Haywood, Polk, Transylvania, McDowell, Mitchell, Madison, Yancey, Jackson, Swain, Macon, Graham, Spartanburg, Greenville, Anderson, Union, Pickens, Oconee, Laurens, Greenwood, Abbeville and also Biltmore Forest, Woodfin, Leicester, Black Mountain, Montreat, Arden, Weaverville, Hendersonville, Etowah, Flat Rock, Mills River, Waynesville, Maggie Valley, Canton, Clyde, Franklin, Cullowhee, Sylva, Cherokee, Marion, Old Fort, Forest City, Lake Lure, Bat Cave, Spindale, Spruce Pine, Bakersville, Burnsville, Tryon, Columbus, Marshall, Mars Hill, Brevard, Bryson City, Cashiers, Greer, Landrum, Clemson, Gaffney, and Easley.

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Dec 30, 2025 • 7:06 PM EST • Health • wlos.com
College football bowl and 2025-26 CFP picks, predictions: Legendary Vegas expert reveals best bets today

SportsLine CFB expert Bruce Marshall reveals betting guide for every College Football Playoff and bowl game

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Dec 30, 2025 • 9:36 AM EST • Sports • cbssports.com
Austin Peay secures 110-59 win against Fisk

CLARKSVILLE, Tenn. (AP) Rashaud Marshall had 24 points in Austin Peay's 110-59 win against Fisk on Sunday.

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Dec 28, 2025 • 10:34 PM EST • Sports • cbssports.com
🙂 Positive (65%)
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College football bowl and CFP picks, predictions: Legendary Vegas expert reveals best bets for today

SportsLine CFB expert Bruce Marshall reveals his betting guide for every College Football Playoff and bowl game

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Dec 26, 2025 • 9:24 AM EST • Sports • cbssports.com
Trump appears in new batch of Epstein documents

The Justice Department released a new batch of documents from Epstein investigation. President Donald Trump’s name is mentioned many times in the documents, including in references to flight records related to Epstein’s private plane. Authorities have not accused Trump of criminal wrongdoing related to Epstein. CNN’s Marshall Cohen reports.

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Dec 23, 2025 • 5:08 PM EST • Politics • cnn.com
I compared TJ Maxx and Marshalls this holiday season. I would only recommend one.

TJ Maxx and Marshalls are two of the best-known discount department stores in the US, but they are not the same.

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Dec 23, 2025 • 1:09 PM EST • Business • businessinsider.com
College football bowl and CFP picks, predictions: Legendary Vegas expert reveals best bets

SportsLine CFB expert Bruce Marshall reveals best bets for every College Football Playoff and bowl game

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Dec 23, 2025 • 11:56 AM EST • Sports • cbssports.com
Kalamazoo salon owner faces financial uncertainty after car crash damages business

WWMT-TV Newschannel 3 provides local news, weather forecasts, notices of events and entertainment programming for Kalamazoo, Grand Rapids, Battle Creek, South Haven, Paw Paw, Portage, Otsego, Texas Township, Oshtemo, Plainwell, Allegan, Holland, Saugatuck, Holland, Wayland, Kentwood, Middleville, Hastings, Marshall, Three Rivers, Sturgis, Constantine, Coldwater, Albion, Wyoming, Hudsonville, Allendale, Byron Center, Hudsonville, Grand Haven, Muskegon, Sparta, Rockford, Belding, Greenville, Ionia, Cedar Springs and their surrounding areas.

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Dec 22, 2025 • 4:13 PM EST • Business • wwmt.com
Ask Pinstripe Alley: Yankees mailbag questions request

Let’s get one last mailbag in for 2025, shall we?

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Dec 22, 2025 • 4:00 PM EST • Sports • pinstripealley.com
College football bowl and CFP picks, predictions: Legendary Vegas expert reveals best bets

SportsLine CFB expert Bruce Marshall reveals best bets for every College Football Playoff and bowl game

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Dec 22, 2025 • 12:52 PM EST • Sports • cbssports.com
Marshall Scholar examines the intersection of books, literature and politics

Jack Wallace, UVA’s 18th recipient of the scholarship, says critical thinking and literacy are antidotes for mistrust generated by technology.

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Dec 18, 2025 • 11:12 AM EST • Politics • news.virginia.edu
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Morehead State knocks off Little Rock 78-64

MOREHEAD, Ky. (AP) George Marshall scored 17 points as Morehead State beat Little Rock 78-64 on Tuesday night in an Ohio Valley Conference opener.

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Dec 16, 2025 • 10:27 PM EST • Sports • cbssports.com
Science in a French City, Which I Shall Not Name

It has a beautiful historic center with typical old European streets and an impressive number of museums. It is a delightful area of narrow cobbled streets, small charming squares, and beautiful old buildings. It is a very old city—more than 2,000 years old. It is a green city with many parks. There are 14 churches and cathedrals in this city, although over the years it has become less Christian and more Muslim. [Alex Gordon]

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Dec 15, 2025 • 7:51 AM EST • Science • sdjewishworld.com
Fourth-Quarter Drought Sends EKU to 75-50 Loss Against Marshall - Eastern Kentucky University Athletics

LEXINGTON, Ky. – Eastern Kentucky University battled Marshall for three quarters but was held scoreless in the fourth quarter, resulting in a 75-50 loss Sunday afternoon at the Clive M. Beck Center.

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Dec 14, 2025 • 2:57 PM EST • Sports • ekusports.com
Photo gallery: John Marshall defeats Magnolia, 80-51

MOUNDSVILLE, W.Va. — Photo gallery from John Marshall’s 80-51 win over Magnolia. (Photo gallery courtesy of Robert Ovies Sports Photography)

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Dec 12, 2025 • 2:36 PM EST • Sports • wvmetronews.com
Sensory play business Squish opens downtown

Kids in Marshalltown have a new play option – Squish, a downtown hands-on sensory play business. Owners Bobbie Slaney and Tiffany Fouts started the business inside the Hellberg’s Jewelers building at 13 W. Main St., with a soft opening on Monday. According to Slaney, the inspiration came when they saw there were not a lot […]

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Dec 8, 2025 • 7:00 PM EST • Business • timesrepublican.com
JIM CLOERN: The scientist and science I mourn

By Ariel Rubissow Okamoto A man died recently who was one of my heroes. Inside his big brain lay the secrets of San Francisco Bay. In one sentence he could explain the relationships between the tiny plants drifting aimlessly in the shallows, the muscular salmon leaping upstream, and the health of the planet. He had a warm smile, a curl to his hair, a ready chuckle. But I did not know this man well. For decades he ran a monthly data […]

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Dec 7, 2025 • 12:16 PM EST • Science • mavensnotebook.com
The Tragedy of Christian Power Politics

“There is a time for war,” says the preacher in Ecclesiastes, “and a time for peace.” Let the present time point toward the time of perfect and ultimate peace, when the swords of nations shall be beaten into plowshares.

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Dec 3, 2025 • 8:00 PM EST • Politics • thepublicdiscourse.com
Shall future military leaders be mere ideological drones?

As my regular reader will recall (Hi, Jeff!) from my mentioning it here dozens of times, I spent the largest part of my 25-plus years as an active-duty Air Force officer teaching at the Air Force Academy in Colorado Springs. Though I taught a wide range of courses during the 15 years I spent there […]

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Dec 2, 2025 • 3:00 AM EST • Politics • coloradopolitics.com