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What to Watch in Saturday’s Republican Senate Primary in Louisiana
Senator Bill Cassidy, who has drawn President Trump’s ire, is fighting for political survival.
Howard Community College Featured in 'State of Business' Address
In his Business Outlook Luncheon remarks at Turf Valley Resort last week, Howard County Executive Calvin Ball outlined how Howard County “stands on business” through five pillars: managing crises, investing in people, backing businesses, making strategic investments, and preparing for the future. Howard Community College appears by name in the pillar that anchors the others: investing in people. Dr. Ball highlighted the $11 million county investment in HCC’s Cathy and Danny Bell Workforce and Trades Center, which will open this fall. He described the facility as a world-class center with state-of-the-art training in key industries, championed by HCC President Dr. Daria J. Willis, and positioned to help Howard County compete with institutions worldwide. He also recognized HCC’s Complete4Success program, supported by a $3.5 million county investment in 2022, as a continuing driver of certifications and degrees that prepare students to enter Howard County’s workforce ready to contribute on day one. Dr. Ball connected HCC’s work to the broader economic moment in the county, including more than 1,580 apprentices now training across Howard County businesses, up from roughly 1,100 in 2018, and the SPARK program that bridges classroom learning to high-demand industries. Each of these efforts depends on the kind of workforce pipeline HCC is built to deliver. Educational Services is one of the top three employment sectors for county residents, alongside Professional, Scientific, & Technical Services and Health Care & Social Assistance. HCC will award 1,263 degrees next week at its annual commencement ceremony, and every year, that output feeds directly into the industries the County Executive named as drivers of Howard County’s growth. The full picture also includes the families who are not yet there. The 2024 ALICE update from United Way of Central Maryland found that 35,346 households in Howard County, 29% of the total, fell below the ALICE Threshold in 2022, meaning they earned more than the Federal Poverty Level but less than the basic cost of living in the county. The Household Survival Budget for a Howard County family of two adults, an infant, and a preschooler reached $118,608 annually, requiring an hourly wage of $59.30 to cover housing, child care, food, transportation, and other essentials. Affluence and economic strain coexist within the same county lines. That gap is the reason higher education and economic development are inseparable. Every certification, associate degree, and apprenticeship credential issued at HCC represents a household closer to crossing the ALICE Threshold and into long-term financial stability. The Bell Center, Complete4Success, Howard P.R.I.D.E., Parent Scholars, and the institution’s transfer-rate gains are significant components of Howard County’s economic mobility infrastructure. HCC is grateful to Dr. Ball for his sustained partnership over nearly eight years of service and for recognizing that this college plays a central role in the economic story Howard County is telling. Standing on business in Howard County means standing alongside the flagship institution that prepares its workforce.
The Dynamics of Escalating Tensions on the Washington-Tehran Axis
The impasse between Washington and Tehran is about the asymmetry between U.S.'s coercive approach to diplomacy and Iran's survival priorities.
Friends List for Java Edition
Sometimes, you don’t want to face that first night in Survival alone. That’s why we’re introducing the first version of a Friends List to Java snapshot, which will give you a way to connect with friends that’s built into the game.
The Latest: Starmer fights for political survival as calls for his resignation grow in UK
U.K. Prime Minister Keir Starmer is fighting for his political survival after a disastrous set of results in local elections for his Labour Party last week. Dozens of Labour lawmakers are calling on...
New drugs could wipe out the “zombie cells” linked to cancer and aging
Researchers found a new way to kill harmful “zombie” cells that linger after chemotherapy and help cancers become more aggressive. These senescent cells survive by relying on a protective protein called GPX4, even while sitting on the edge of a deadly iron-triggered collapse. New drugs remove that protection, causing the cells to self-destruct. In mice, the approach reduced tumor size and boosted survival, hinting at a promising new cancer therapy.
The Latest: Starmer fights for political survival as calls for his resignation grow in UK
U.K. Prime Minister Keir Starmer is fighting for his political survival after a disastrous set of results in local elections for his Labour Party last week. Dozens of Labour lawmakers are calling on Starmer to resign. A resignation announcement could possibly come after a Cabinet meeting on Tuesd...
The Latest: Starmer Fights for Political Survival as Calls for His Resignation Grow in UK
U.K. Prime Minister Keir Starmer is fighting for his political survival after a disastrous set of results in local elections for his Labour Party last week. Dozens of Labour lawmakers are calling on Starmer to resign. A resignation announcement could possibly come after a Cabinet meeting on Tuesday,
Sarasota waterfront business open for decades forced to move
Popular Sarasota tourism business unveils survival plan ahead of May 14 move.
Longtime Sarasota waterfront business reveals survival plan
Longtime Sarasota waterfront business unveils a plan ahead of forced move.
Suicide survivor inspires hope during Mental Health Awareness Month
A Chicagoan is sharing her story of survival to remind others healing is possible during Mental Health Awareness Month.
A live two-toed sloth is coming to Richmond's Science Museum
It's part of a touring exhibition running from May 23 to Sept. 7 called "Survival of the Slowest."
UK PM Starmer battles for political survival in pivotal speech as gilt yields rise
Starmer is expected to say that key issues of growth, defense, the U.K.'s relationship with Europe and energy must be urgently addressed.
California Republican Incumbents Race to the Right as Redistricting Forces Standoff
Forced to fight for political survival because of redistricting, Ken Calvert and Young Kim, both Republicans, are accusing each other of being insufficiently MAGA.
IN8bio Reports First Quarter 2026 Financial Results and Recent Business Highlights
Advancing next-generation γδ T cell engager platform with initial animal data expected in 2026Reported glioblastoma (GBM) data showing ~97% improvement in progression-free survival vs. standard-of-care; updated median overall survival (mOS) data to be presented at ASCO 2026Hosting R&D Day on May 21, 2026 in New York City NEW YORK, May 07, 2026 (GLOBE NEWSWIRE) -- IN8bio, Inc. (Nasdaq: INAB), a clinical-stage biopharmaceutical company developing innovative gamma-delta (γδ) T cell therapies and γδ
Get tickets to Business Report’s Women’s Leadership Symposium for revealing conversations about what transformation really looks like
If there’s one thing the past few years have made clear, it’s that the ability to adapt isn’t just an advantage—it’s survival. Business Report‘s 2026 Women’s Leadership Symposium is built around exactly that reality. Get tickets and additional details about the Women’s Leadership Symposium and the Influential Women in Business celebration here. Themed “The Power of […]
Mamata Banerjee, West Bengal election results 2026: India’s fiercest female politician faces a fight for survival
Mamata Banerjee loses West Bengal state, throwing her party - and political future - into doubt.
COA and Flatiron Health Study Finds Patients May Experience Longer Survival in Community Oncology Settings
Patients diagnosed with metastatic breast cancer and non–small cell lung cancer had longer survival compared to national benchmarks when treated in independent community oncology practices, according ...
📸 Mega tifo against BVB, Gladbach fans deliver spine-tingler!
Borussia Mönchengladbach can secure survival in the Bundesliga with a home win against BVB.Accordingly, the atmosphere at Borussia-Park was already heated before kick-off. The main reason for that wa...
Malaria didn’t just kill early humans, it shaped who we became
Long before humans spread across the globe, a deadly disease may have quietly shaped where our ancestors lived—and even how we evolved. New research reveals that malaria didn’t just threaten early human survival; it actively pushed populations away from high-risk regions across Africa, fragmenting groups over tens of thousands of years. This separation influenced how different populations met, mixed, and exchanged genes, helping shape the genetic diversity we see today.
Business Leaders Say Adapting to AI Is Essential to Survival
Executives from IBM, VaynerX and Deepblocks talk to TIME100 about the blistering pace of change all companies are facing in the age of artificial intelligence.
‘Living in survival mode’: Houston’s embattled immigrant community faces health, climate and petrochemical crises
Amid immigration raids, chemical spills, massive floods and costly healthcare, less-affluent residents of one of the most diverse US cities struggle to pull through
FDA authorizes early access for experimental pancreatic cancer pill
The FDA said the action recognizes the dire need for a drug to improve survival for pancreatic cancer patients, who face the worst survival odds in oncology.
Exiles have 'easier game' as five clubs fight for survival
Iwan Roberts says Newport County have the kindest fixture of all the sides in the League Two relegation scrap as they prepare for Saturday's season-defining trip to Barrow (15:00 BST). Newport, in 21st, and 20th-placed Tranmere are a point better off than Harrogate and Crawley.
Computer science grad earns IBM fellowship for AI research
Modern medicine runs on data organized into tables and charts that help doctors make fast, informed decisions. Survival rates and prescription side effects are often distilled into formats that can be scanned in seconds. But that clarity doesn’t come easily. The data must be extracted and organized, often through a time-consuming process that can leave critical information buried deep in research reports.Naman Ahuja wants to change that.
Women live longer after TAVR than men
Researchers tracked real-world data from 600 TAVR patients, following each one for approximately five years. Survival rates were similar for men and women early on, but then women started experiencing better outcomes after three years.
'Survival no longer feels impossible'
When Xavi Simons' knee gave way, many of us thought that was it. All season, when Spurs have come face to face with adversity, they have crumbled. It has left us questioning the players' desire and mental fortitude.
Alice Henderson’s “Storm Warning” Is a Wild Ride of Survival Science and Savage Threats
Storm Warning is Alice Henderson’s fifth wild and wooly, storm-tossed, action-packed suspense novel featuring protagonist wildlife biologist and environmentalist adventurer Alex Carter. Her current assignment to study and protect imperiled hawksbill turtles in tropical Hawai’i seemed like an idyllic vacation of sun, surf, swimming and snorkeling. The intensive military survival training taught to her by
Multiple GLP-1 drugs linked to lower AFib risk
The popular drugs, originally developed to treat diabetes, were also associated with an improved survival rate. Benefits were seen in patients who did and did not lose significant weight as a result of treatment.
Analysis: VAR frustration for Toffees
It isn't that long since Everton were in West Ham's position and fighting for Premier League survival - but now they are in the battle to secure European football next season and, particularly for that reason, this will have been a frustrating result. David Moyes' side have one of the best away records in the Premier League and it looked they would earn a point with Kiernan Dewsbury-Hall's late strike. Moments before Dewsbury-Hall equalised, the Toffees thought they had a penalty when the ball struck Mateus Fernandes' hand inside the box as he grappled with Thierno Barry.
Aggressive “hulk” lizards are wiping out millions of years of evolution
For ages, wall lizards coexisted in three distinct color types, each with its own strategy for survival. Now, a powerful green variant is taking over. These dominant “Hulk” lizards are outcompeting the others, causing yellow and orange morphs to vanish. It’s a dramatic reminder that evolution can flip the script much faster than expected.
Newport a 'strong force' for critical Oldham game
Christian Fuchs says belief is strong in his Newport County side, as they face Oldham Athletic on Saturday with the potential to secure League Two survival.
🚨 Line-ups ready: Mallorca and Valencia open the matchday
RCD Mallorca and Valencia CF kick off LaLiga Matchday 33 this Tuesday in a dramatic clash in the battle for survival. Separated by just one point, 14th and 15th in the table face off in one of the fir...
The Science of piRNA and Predicting Death With a Blood Test
A new study analyzed piRNA — first discovered in 2006 — as a strong predictor of short-term survival in older patients. It could one day be a simple blood test.
A whole new way to prevent death from sepsis shows promise
Filtering a protein that may cause sepsis out from the blood has shown promising signs for improving survival
Historic London rugby club fights for survival
The volunteer‑run rugby club says rising costs threaten its future and seeks urgent support.
'Pompey fought for their lives'
Portsmouth on the verge of Championship survival following narrow Leicester win.
Eight days key to Portsmouth's likely survival
While Portsmouth are not mathematically safe, their past three results in eight days have been crucial to their hopes of staying up.
Experimental drug doubles one-year survival in pancreatic cancer
A new drug that works by making tumors more susceptible to chemotherapy and the immune system has increased survival in those with advanced pancreatic cancer in a trial.
How an unsolved medical mystery became a life-saving breakthrough
Inside the deadly disease confounding medicine, researchers piecing together clues and the breakthrough that meant survival for thousands of patients.
Sharks and tuna are overheating and running out of options
Some of the ocean’s fastest and most fearsome predators—like great white sharks and tuna—are running hotter than expected, and it’s costing them dearly. New research shows these warm-bodied fish burn nearly four times more energy than cold-blooded species, forcing them to eat more while also struggling to shed excess heat. As oceans warm, this creates a dangerous “double jeopardy”: rising temperatures push them closer to overheating, while shrinking food supplies make survival even harder.
Fuchs calls for Newport focus in survival battle
Christian Fuchs discusses the rollercoaster of emotions as Newport prepare to travel to Cheltenham in a match that could determine their EFL future.
New Stoner Survival Dealing 4X Rewards as LD Organics Presents: The 420 Event
The man with the van and the plan is putting his stamp on Los Santos this 420 as LD Organics Presents: The 420 Event. Celebrate with a new Hunting Pack (Get Lamar) location that’s dispensing 4X Rewards, enjoy a kaleidoscope of hallucinations along with...
How Artemis 2 commander Reid Wiseman saved the mission's moon mascot: 'It's hard not to love this little guy. I can't let Rise out of my sight'
"I stuffed that little guy in a dry bag we had in our survival kit, and hooked the bag onto my pressure suit."
Dons boss Robinson will not relax until safety is secured
Stephen Robinson does not want Aberdeen to relax during their two-week break after they recorded a much-needed 2-0 win over Hibernian to boost their William Hill Premiership survival hopes. Kevin Nisbet netted from the penalty spot after Grant Hanley was sent off for hauling down Toyosi Olusanya and the Scotland striker added a second with 15 minutes to go to end a nine-match winless league run. The Dons are five points above Kilmarnock, who sit in the relegation play-off spot with five games to play, and the two teams clash at Pittodrie in the next round of Premiership fixtures which does not take place until April 25.
Inside the $350 million missile silo that could become a data center
Tech firms are turning missile silos and abandoned mines into secure data centers as Americans flock to survival camps amid rising fears of world war.
Life on Mars? Tiny cells just survived shock waves and toxic soil
Mars may be hostile, but it might not be entirely unlivable. In lab experiments, yeast cells survived simulated Martian shock waves and toxic perchlorate salts—two major environmental threats on the Red Planet. Their secret weapon was forming protective molecular clusters that shield critical cellular functions under stress. Without these defenses, survival plummeted, pointing to a potential universal strategy life could use beyond Earth.
Hungary’s Viktor Orban struggling for political survival ahead of vote
Hungarian prime minister and his Fidesz party face first closely contested polls in Sunday's parliamentary election.
Swashbuckling co-op survivor Windrose sets sail into early access next week, which means it's time to battle Blackbeard and a big flower
Pirate survival game Windrose releases in early access next week, its devs have revealed with a new trailer.
Don’t Starve Elsewhere announced for PC
Klei has announced Don’t Starve Elsewhere, a new Don’t Starve survival game. It will launch for PC via Steam. A release date was not announced.
Highly anticipated pirate survival game Windrose lands a release date, and it's setting sail very, very soon
Pirate survival game Windrose finally has a release date, and it's hoisting anchor and sailing into Steam early access next week.
Road to Vostok's hot start on Steam has "secured the entire production budget" the Finnish survival shooter needs for "years to come", dev says
Road to Vostok, a Finnish survival shooter, has already secured the budget it needs for years to come following an early access release, its developer says.
A good point but not enough for Pompey's survival
BBC Radio Solent's Andrew Moon on the 2-2 draw between Portsmouth and Oxford and the impact on the Championship relegation battle.
Former Geisinger CEO: U.S. health systems must replace huge numbers of people with AI
“Health care will become autonomous because the survival of health systems depends upon it,” writes former Geisinger CEO Glenn Steele.
With HCMC’s survival threatened, staff and leaders call for state action
Hospital employees and county leaders warn of statewide 'catastrophe' if lawmakers don’t act to direct more funds to the safety-net hospital.
State Of Decay 3 Proves Its Not Dead With New Alpha Playtest
The zombie survival sim is calling for fans to try out the sequel
Kings beat Blues in OT, take Wild Card spot lead
LOS ANGELES -- When battling for postseason survival, getting wins is the only thing that matters, no matter how ugly they may be.
Trump Told Me All His Shady Business Secrets: Professor
Leadership expert Jeffrey Sonnenfeld dissected the behavioral patterns behind Trump’s rise, survival, and power plays.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
After Centuries of Destruction, Scientists Have Figured Out How To Best Restore Oyster Reefs
Scientists found that mimicking the geometry of natural oyster reefs can significantly improve the survival of young oysters in restoration efforts.
Why Do Animals Glow? The Science of Bioluminescence
From ocean depths to forests, some animals glow — and it’s key to their survival.
The Long Dark returns to Xbox Game Pass today
Survival fans are in for a treat today, as Hinterland's fantastic The Long Dark returns to Xbox Game Pass for console, PC, and handheld.
Scientists Stunned: Colossal Eggs Discovered 3,500 Meters Beneath an Active Volcano
Beneath an active seafloor volcano off Vancouver Island, researchers have documented a congregation of giant eggs at roughly 3,500 meters, a discovery that reframes how life can flourish under extreme conditions. The eggs belong to the Pacific white skate, an elusive deep‑sea species adapted to cold, crushing pressure and perpetual darkness. What seemed an unlikely nursery is actually a geothermally warmed refuge, where subtle heat helps embryos survive a marathon incubation. The finding links volcanic energy to a quiet engine of biodiversity, turning a hostile landscape into an incubator. A living volcano, a hidden nursery The seamount long assumed dormant now exhales mineral‑rich, shimmering plumes, proof of hydrothermal life at depth. Expedition cameras swept across black basalt and pale bacterial mats, revealing vents that pulse with warmth. That warmth, though modest by human standards, alters the physics of development for cold‑adapted embryos. In a realm where metabolism creeps, even a few degrees can mean faster growth and higher survival. The volcano is not only active; it is ecologically formative, drafting a blueprint for a thriving oasis. Giant eggs and a skate built for the abyss The Pacific white skate, Bathyraja spinosissima, is built for the abyss: broad wings, armored spines, and a life history that trades speed for endurance. Females lay outsized, rectangular “mermaid’s purses,” often 46–50 centimeters long, packed with rich yolk to fuel years of growth. In the frigid deep, embryos can require around four years to hatch, a timeline that magnifies every energetic advantage. The scale is striking—large eggs, large adults, and a textbook case of deep‑sea gigantism. The volcano’s gentle heat may literally shave months or years from the wait. Why heat matters at the bottom of the sea Hydrothermal circulation delivers low‑level warmth without the turbulence that would scatter fragile egg‑cases. Slightly elevated temperatures accelerate enzyme kinetics, nudging development along while keeping embryos within a safe range. Mineral‑laden fluids likely shape local microbiomes, which, in turn, can influence biofilms on egg surfaces. The environment acts like a slow, steady incubator, countering the deep sea’s tyrannies of cold and scarcity. For a species with long maturation and few offspring, every incremental boost compounds across generations. An ecosystem sculpted by fire and water Seafloor volcanoes create steep environmental gradients, stitching together hot vents, cool eddies, and mineral gardens into mosaic habitats. Microbes harvest chemical energy, seeding food webs that support crustaceans, fishes, and skates. Cameras documented egg‑cases nestled among rocky ledges, near communities nourished by vent‑driven chemistry. These islands of productivity behave like deep‑sea oases, sustaining life far beyond the vent orifice’s flickering light. The nursery’s success underscores how geological forces engineer biological opportunity. “Finding a cradle of life tucked beneath a breathing volcano reminds us that the planet’s harshest places can be profoundly generous.” What the discovery could change The nursery reframes conservation priorities in regions where volcanism quietly underwrites reproduction. Protecting hydrothermal corridors could safeguard entire lifecycles, not just charismatic adults spotted during occasional surveys. It also sharpens questions about how climate‑driven shifts in ocean circulation might influence vent activity, temperature fields, and embryo survival. With methodical mapping, time‑series cameras, and environmental DNA, scientists can track whether nurseries remain stable or drift with geologic rhythms. Key implications include: Enhanced understanding of deep‑sea reproduction at hydrothermal sites. New conservation targets centered on geothermal nurseries. Comparative studies with other volcanic regions, from the Galápagos to rift zones. Biotechnological insights from organisms adapted to long, cold development. Better models of how seafloor heat shapes regional biodiversity. Methods behind the revelation Remotely operated vehicles threaded through chimney fields, gathering video, temperatures, and mineral signatures. High‑definition imagery captured the distinctive, horned egg cases, their edges dusted with fine volcanic silt. Geochemical profiles mapped how heat and chemicals disperse, outlining the “thermal lanes” where eggs most cluster. Combined, these datasets reveal a nursery organized by geothermal topography, with egg‑cases concentrated in pockets of gentle, sustained warmth. A fragile boon in a changing ocean Deep‑sea environments feel remote, yet they intersect with global pressures: mining proposals, cable routes, and shifting oxygen levels. The nursery’s resilience hinges on stable heat flow, intact substrates, and minimal disturbance from noise or sediment. Safeguarding such places is not just about protecting novelty; it preserves a slow, ancient strategy that lets large, long‑lived animals endure in the coldest reaches of the Pacific. Where geology and biology meet, the planet’s deep time still writes living stories. This volcano‑warmed nursery adds a vital chapter to that story, revealing how subtle thermal gifts can tip the scales toward life in the abyss. With each dive, researchers trace the contours of an unseen world, where fire feeds water, and water—against all odds—feeds the future.
Polar bears are struggling in every aspect of their lives, but scientists are hoping to prevent extinction through genetic management
Polar bears are struggling to survive as Arctic ice disappears, limiting food, reducing habitat, and pushing their ability to adapt.
‘Canadians don’t want to come here any more’: anger over Trump squeezes US border businesses
Shops and restaurants once bustling with tourists now struggle for survival as Canadians think twice about crossing the border
Eskimo kiss, anyone? Science explains nose-to-nose contact between mammals
A new study analyzes why the social gesture is important when it comes to information and survival, even among antisocial animals
Poppy Playtime Chapter 6 Plans, Film Adaptation: Mob Entertainment
Survival horror game "Poppy Playtime" launched its fifth installment Feb. 18, breaking records set by the video game franchise's previous debuts.
Alien Deathstorm: Sci-fi Survival and Action Combine for a New First-Person Horror Hybrid
New from Rebellion (Atomfall, Sniper Elite) is Alien Deathstorm, an atmospheric first-person horror hybrid, coming to Xbox and Xbox Game Pass.
Feature: Where The Heck Do You Start If You've Never Played Resident Evil?
Enter the world of survival horror
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Beyond Water: Why WASH Matters for Dignity, Health and Survival
Discover how Water, Sanitation and Hygiene (WASH) are vital to supporting and empowering refugees this World Water Day.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
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'Dragon Mama' review: Part two of Sara Porkalob's Filipina family saga
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Alawite Politics After Assad
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This small Minnesota town pulses with immigrant-run businesses. ICE has threatened their survival
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Blight: Survival Remerges After 1.5 Million Steam Wishlists and a Viral Trailer With a New Look at Gameplay
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Palantir CEO: Value Creation Is All That Matters In War Or Business
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Smart Plants in a Changing World Science
The Salk Institute is teaming up with the Del Mar Foundation for a three-part webinar series to highlight Salk's foundational research in brain health, cancer, and agriculture. Join us on Wednesday, March 11, at 10 a.m. to learn directly from Salk scientist Lucia Strader about how plants sense and respond to their environments, and how understanding these natural survival strategies can help us develop crops that thrive in a changing world. The Del Mar Foundation is offering a 1:1 Challenge Match through June. Gifts made during the webinar series will be matched dollar-for-dollar, doubling your impact on critical research. Donors who give $1,000 or more to an area of greatest need will also join the Discovery Society, with special access to Salk news and events. Salk Institute on Facebook / Instagram
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Spirits, survival shows and saju: Korea's unlikely shamanism entertainment boom
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After a harrowing start, Resident Evil: Requiem settles into the overly familiar
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Scientists reverse muscle aging in mice and discover a surprising catch
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‘We were right’: He took Trump’s tariffs to the Supreme Court and won
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34-year-old spent $16K to start a side hustle, built it 20 minutes at a time—now her business brings in up to $90K a month
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'I think that massively plays into Leeds' hands'
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Mysterious RNA led scientists to a hidden layer of cancer
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Kevin O'Leary Warns '80% Of Businesses Fail In The First 36 Months' As High Customer Acquisition Costs Drain Startups
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One in three people carry this brain parasite but the body has a kill switch
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Charlotte man's survival highlights CPR's lifesaving power, spurs focus on cardiac health in Mecklenburg County
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