SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " target " 2,779 found 🔀 AI-powered Shuffle
Juventus and Roma are interested in new Italy star
Issa Doumbia has emerged as a potential transfer target for Juventus after receiving his first call-up to the Italian national team under Roberto Mancini during the September and October international...
Abbott targets Hinojosa over whether she backs a state income tax
For weeks now he has been pointing to a 2019 vote as evidence that his opponent, Gina Hinojosa, wasn’t against income taxes and “is dangerous for Texas.”
Warriors Reportedly Missed Out on Preferred Target in 2026 NBA Draft
Who did the Golden State Warriors want in the draft?
Iowa State falls at No. 8 BYU
PROVO, Utah — Iowa State (3-3, 1-2 Big 12) dropped a 24-10 decision to the No. 8 Brigham Young (5-0, 3-0 Big 12)Friday night. Cyclone quarterback Jaylen Raynor completed 16 of 29 passes for 98 yards and a touchdown in the loss. His two favorite targets were Ty Claiborne, Tyler Fortenberry and Omari Hayes who […]
HHS Recommends Science-Based Thresholds to Target Dangerous Enhanced Kratom Products
HHS provided a new recommendation to the Drug Enforcement Administration that establishes science-based thresholds.
Stanford Scientists Identify Enzyme That May Promote Cartilage Regeneration in Arthritis
Stanford researchers identified an enzyme that may restore cartilage repair signals in arthritic joints, offering a potential drug target backed by mouse and human tissue results.
A Republican attack ad misidentifies its Democratic target. Twice.
A GOP ad used a photo of Republican Myron Lizer instead of Democrat Jonathan Nez. Nez is challenging Rep. Eli Crane (R-Arizona).
Fueling Performance: Kansas Checkoff Keeps Beef Front and Center in High School Sports
Targeting the next generation of beef consumers, the initiative reinforces beef’s role as the premier protein for athletic fueling and recovery.
US imposes sanctions on international criminal court
Trump administration says US ‘doesn’t need’ ICC after accusing court of unfairly targeting Americans for war crime charges
Fazio Shares Healthcare Affordability Plan » CBIA
Connecticut gubernatorial candidate Ryan Fazio outlined a healthcare affordability plan targeting high costs and workforce challenges.
Pokemon TCG's Delta Reign Expansion Is Finally Up For Preorder On Amazon and Target — And One Box Is Already Under Market Price
Pokémon TCG Delta Reign preorders are now live at Amazon and Target, including Booster Bundles below market price, Elite Trainer Boxes, and 36-pack Display Boxes.
'NAZA' review: Israeli documentary is a living nightmare
Documentary "NAZA" examines how Israeli forces use AI and surveillance systems to target and kill Palestinians.
Arizona candidate says she was raped while posting campaign signs: ‘maybe I was targeted’
Trump bucks and the politics of mailing checks
The checks started going out last week, nearly one million of them, and mostly to battleground states. With a return address for the U.S. Treasury and a letter enclosed signed by President Donald Trump, these one-time checks for $500 were ostensibly government rebates for Obamacare enrollees who overpaid. In the accompanying letter, however, Trump attacks his predecessor and talks about his record in office on an important issue he’s not polling well on, which makes it seem more like the most expensive political mailer in U.S. history. The average piece of direct mail costs between 30 cents and $3, according to Mail Processing Associates, a print, mail, and fulfillment company. At $500 a pop plus roughly 50 cents each to issue the paper check, the cost of Trump’s healthcare mailer sent to more than 950,000 enrollees comes in at more than $475 million. Trump’s midterm healthcare message “For years, the Biden Administration overcharged you to fund the operation of HealthCare dot gov,” Trump wrote in the letter. “That money belongs to hard-working Americans, not the Government, and now, I am returning it to you!” In the letter, Trump makes false and misleading claims about his administration’s record on healthcare costs, an issue Democrats have a 20 point advantage on over Republicans, according to a recent poll from KFF, a nonpartisan health policy think tank. Trump touts his administration’s TrumpRX program, which he claims is “delivering massive discounts.” However, new research from KFF found that of a selection of drugs available on the TrumpRX platform, just five were the lowest price, while 13 were the highest price. Trump also falsely claims in the letter that he’s fighting to lower healthcare costs. In reality, average monthly premium payment costs for enrollees rose 58% under Trump while marketplace sign-ups declined 5%, per KFF. Under Trump’s One Big Beautiful Bill Act, it’s estimated 10 million more Americans will be uninsured by 2034. You get a check and you get a check and you get a check Trump’s long promised cash outs to his fans, from his days as a casino operator and gameshow host to his presidency. During the early days of the COVID-19 pandemic in 2020, the first Trump administration made the unprecedented move to put Trump’s name on checks that went out under the CARES Act (notably the $500 refund checks this time around don’t feature Trump’s name). Ever since, Trump’s been chasing that high. In his second term, Trump’s promised more stimulus that never arrived, like refund checks from DOGE cuts and tariffs, while he said at his party’s convention last month that he’d give out $5,000 checks to everyone if Republicans win in November. In reality, DOGE overstated its cost cutting and Trump’s government actually now spends more than former President Joe Biden’s, while Trump’s tariffs actually grew the trade deficit. His proposal for $5,000 checks would add about $1.2 trillion to the national debt. The problem is there’s no money to give. These $500 checks — plus $90 Medicare rebate checks also going out as well as $250 deposited this week in some Trump Accounts for kids courtesy Dell Technologies CEO Michael Dell and his wife Susan — represent the closest Trump’s going to get to making good on his promise to deliver cash fast. And the checks seem especially targeted. Though the $500 checks went out to enrollees in one of 30 states that use the federal HealthCare dot gov marketplace, a Reuters review found 71% of the payments, or $339 million, went to enrollees in 13 states that have the most competitive elections for governor and U.S. Senate. Most Americans don’t buy it Could Trump bucks sway the election? An Economist-YouGov poll found 57% of U.S. adults doubt Trump will deliver on his promise for $5,000 checks, compared to 21% who do. “I’m waiting on my DOGE check and I’m still waiting on my tariff check,” one 2024 Trump voter who’s since turned on him told a recent focus group. “It felt like kind of trying to buy people’s votes, which honestly felt like in elementary when the class president was like, hey we’re going to take you to the water park if you vote for me. It’s like, I don’t think it works like that.” But for voters in swing states who got a check, it could still matter. One survey published in 2022 found receiving a physically personalized check in the mail during the pandemic was associated with a much greater self-reported likelihood of voting for Trump in 2020, and those gains mainly came from out partisans. The issue for Trump comes if these checks are mostly going to Obamacare enrollees whose premiums have gone up by more than just $500 since he took office and who view the money as something like a bribe before the election rather than an actual long-term solution to lowering household costs. Spending $500.50 per mailer would be absurd as a normal campaign expenditure, but since Trump’s checks and letter are a government rebate, his campaign and super PAC didn’t have to spend a dime and he got out his message regardless. If enough voters in key states are swayed by the one-time payment, it could prove to be the best $0 the Trump campaign spent. Subscribe [ ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) [ Why independent candidates are making independence central to their brand ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) Hunter Schwarz · Oct 6 [ Read full story ](https://www.yellopolitics.com/p/why-independent-candidates-are-making) [ ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) [ These designers and grocery nerds will brand Mamdani’s NYC grocery stores ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) Hunter Schwarz · Oct 2 [ Read full story ](https://www.yellopolitics.com/p/these-designers-and-grocery-nerds) Trump wants to turn his first-ever golf course into a government course for presidents
Six Flags Entertainment (NYSE:FUN) Stock Price Target Lowered at Citigroup
Citigroup lowered their price target on Six Flags Entertainment from $17.00 to $13.00 and set a "neutral" rating for the company in a report on Thursday.
Flutter Entertainment (FLUT) Stock Trades Up, Here Is Why
Shares of global online betting powerhouse Flutter Entertainment (NASDAQ:FLUT) jumped 4.4% in the afternoon session after Citi analyst Monique Pollard upgraded the company from a Neutral rating to a Buy rating. According to StreetInsider, Susquehanna analyst Joseph Stauff separately cut his price target to $100 from $115 and kept a Positive rating. He said third-quarter profit is likely to be lower and that the weaker result is already discounted. The stock, he said, is most sensitive to FanDuel
Real Madrid Identify Arsenal's Mikel Merino As New Midfield Option
Mikel Merino has reportedly emerged as a potential transfer target for Real Madrid. The Spanish giants are keen on the versatile midfielder but for now, no talks have taken place between Madrid and Arsenal over a possible deal.
Florida woman charged in $330K fraud case targeting Hanover business’ bank account
A 41-year-old Florida woman is facing felony charges in “an elaborate computer fraud scheme” that left a Hanover County business out $330,000.
Newrez, eXp Realty Form Joint Venture To Target Purchase Business
eXp Realty is replacing Kind Lending with Newrez as its mortgage joint venture partner, bringing one of the nation's largest nonbank lenders into its national real estate network in a move that could expand Newrez's reach into purchase lending.
Wedbush Cuts Flutter Entertainment (NYSE:FLUT) Price Target to $110.00
Wedbush cut their price target on Flutter Entertainment from $126.00 to $110.00 and set an "outperform" rating on the stock in a research note on Thursday.
CASCADES' NEW GHG EMISSIONS REDUCTION TARGETS APPROVED BY THE SCIENCE BASED TARGETS INITIATIVE
/PRNewswire/ -- Cascades inc. (TSX: CAS) announced that its new 2035 greenhouse gas (GHG) emissions reduction targets have been approved by the Science Based...
Fucoidan research surpasses 5000 papers as Marinova targets gut health, immunity and men's urinary health
With 550+ studies published in 2025 alone, Marinova is positioning its FDA GRAS and EU Novel Foods-authorised Maritech organic fucoidan for formulators targeting the prebiotic, healthy ageing and prostate health categories
Toss-ups, triage and targets: How to read the wide-open 2026 House map
Both parties are spending heavily in roughly 60 House districts — where Trump won by an average of nine points in 2024 — that could be key to deciding control of the chamber, an NPR analysis finds.
Kilgore Tec expands its distribution, workforce
Kilgore Tec Products Inc. is expanding its distribution territory and plans to grow its Spokane Valley workforce by about 40% as the building-envelope contractor targets 100% sales growth over the next five years.
PENN Entertainment, Inc. (NASDAQ:PENN) Stock Has Average Target Price of $23.94 According to Analysts
Shares of PENN Entertainment, Inc. (NASDAQ:PENN - Get Free Report) have been given an average recommendation of "Moderate Buy" by the twenty ratings firms that are covering the company, MarketBeat Ratings reports. One analyst has rated the stock with a sell rating, six have assigned a hold rating an
A Business and Regulatory Navigator to Accelerate Electrification
Demand for electrification is moving faster than the system it connects to. Electric vehicles, heat pumps and electrified industrial processes are scaling1, and the the United Nations Climate Change Conference (COP31) Presidency has set a global target of 35% of final energy demand met by electricity by 2035, up from around 21% today.2 What now
Microsoft Launches $2,599 Surface Laptop Ultra to Take on MacBook Pro
Microsoft today announced launch timing and pricing for the Surface Laptop Ultra that it unveiled earlier this year. The 15-inch Surface Laptop Ultra is priced starting at $2,599, undercutting Apple's $2,999 16-inch MacBook Pro, and it targets the same creator and developer market. Microsoft says it is built for "demanding creative, software development, AI, engineering, and 3D workloads".
Chicago business owners push back on proposed ordinance targeting ‘troubled’ businesses
Some aldermen see their ordinance as a potential solution to crack down on criminal activity, and businesses that are accused of enabling criminal activity.
SpaceX is a real company, with real numbers and real business, says Jim Cramer
'Mad Money' host Jim Cramer takes a look at Goldman Sachs' recent price target change on SpaceX and what is behind it.
Six Flags Entertainment Corporation Stock 12‑Month Price Target Cut to $20.79, Implies 72% Upside
Explore more price target data and ratings for Six Flags Entertainment Corporation on the Forecasts tab, and track all previous and future analyst recommendations for Six Flags Entertainment Corporation in the dedicated News Flow.Select reference data provided by FactSet. Copyright © 2026 FactSet R…
Science on Target: Q3 Publications from our Innovation Ecosystem
Antisense Oligonucleotide Tofersen Distribution in the Central Nervous System of SOD1-ALS Autopsy Tissue Donors. Guise AJ, Sellon MT, Roemer SF, Monine M, Comfort Harris NT, […] Plowey ED. JAMA Neurol. 2026 Jul 6:e262195. doi: 10.1001/jamaneurol.2026.2195. Epub ahead of print. PMID: 42406382; PMCID: PMC13338845. Using human 3D organoid models to gain mechanistic insight in motor neuron […]
Pork Politics Heat Up as American Meat Producers PAC Targets Save Our Bacon Act Backers
While the campaign frames its messaging around family farms and foreign ownership, industry groups warn of animal rights strategists driving the multi-million-dollar push to preserve Prop 12.
Science on Target: Q3 Research We Enable
Read on for updates across the Research we Enable Postmortem Tissue (PMT) Core The Target ALS Postmortem Core has now collected brain and spinal cord tissue from over 650 cases, making it the largest and most comprehensive ALS tissue repository worldwide that is accessible with no-strings-attached to the global research community. This robust and expanding […]
Science on Target: Q3 Research We Conduct
The Target ALS Global Natural History Study (GNHS) is entering a new phase of discovery. As the only international, longitudinal study generating deeply characterized clinical, genomic, and biofluid data to accelerate ALS biomarker discovery and therapeutic development, the GNHS is now beginning to deliver large scale datasets and resources needed to support new insights into […]
Science on Target: Q3 Research We Fund
$2.4 million Invested in Biomarker Innovation ALS is a heterogeneous disease with distinct subpopulations of cases clustering together based on common underlying biology and with distinct differences in the clinical time course and manifestation of disease. Biomarkers are therefore critical for enabling precision medicine to deliver the right therapy to the right individual at the […]
Flutter Entertainment plc Stock 12‑Month Price Target Cut to $131.5, Implies 72% Upside
Explore more price target data and ratings for Flutter Entertainment plc on the Forecasts tab, and track all previous and future analyst recommendations for Flutter Entertainment plc in the dedicated News Flow.Select reference data provided by FactSet. Copyright © 2026 FactSet Research Systems Inc…
Accel Entertainment, Inc. Stock 12‑Month Price Target Raised to $16.12, Implies 47% Upside
Explore more price target data and ratings for Accel Entertainment, Inc. on the Forecasts tab, and track all previous and future analyst recommendations for Accel Entertainment, Inc. in the dedicated News Flow.Select reference data provided by FactSet. Copyright © 2026 FactSet Research Systems Inc…
Analysis | Trump gets caught in the weave and hands Democrats a target
The president’s misinterpreted comments about Los Angeles and San Diego created opportunities for his foes and confusion for his allies.
Iran's Islamic regime continues war against secular entertainment industry
Tehran steps up its cultural crackdown, targeting cafes and theaters over mandatory hijab rules, 'vulgar' music, and on-stage contact.
Lions Linked to Blockbuster Jalen Ramsey Trade
ESPN insider Jeremy Fowler floated Steelers star Jalen Ramsey as a potential Detroit Lions trade target as Brad Holmes searches for secondary help.
Less Than 1% Of International Development Finance Targets Air Pollution
International development lenders committed $4.7 billion in 2024 to projects aimed explicitly at reducing air pollution, less than 1% of all international development finance, according to an annual analysis published Tuesday by the Clean Air Fund (CAF).
Nexira spotlights menstrual health ingredient BloomEase and ViNitrox vascular data at SupplySide Global
New clinical findings show ViNitrox improves Flow-Mediated Dilation by 41% versus placebo — while Nexira enters the longevity segment with NU4LIFE and VinOgrape Plus targeting mitochondrial and microbiome health
Trump’s LA and San Diego comments ‘dangerous, if not treasonous’, says Newsom
California governor critcizes president for ‘putting a target on two of our biggest cities and one of America’s largest naval hubs’
Today’s Papers: Esposito obsession, Malago replaces himself
La Gazzetta dello SportCome back like this! Sinner return: ‘I’ll see you in 2027’The knee, the choice of tournaments, the therapy: The plan for his return. Target Australian Open in January but...
Angus Taylor’s immigration plan misses the target – on politics and on policy
The most surprising aspect of the Coalition’s policy is that in six pages of detail there is not a single mention of the labour market
Texas voters get ‘Are you white?’ political texts targeting James Talarico
The messages direct recipients to a site paid for by American Political Action Committee, whose website identifies longtime conservative Alan Gottlieb as its founder.
PENN Entertainment (PENN) Stock Trades Up, Here Is Why
Shares of casino, sports betting and entertainment operator PENN Entertainment (NASDAQ:PENN) jumped 5.3% in the pre-market session after Deutsche Bank upgraded the company to Buy from Hold and raised its price target to $25 from $23.
Cle Elum businesses targeted in burglaries
Multiple local businesses in Cle Elum were targeted in a series of overnight burglaries early last Thursday morning.
Health officials warn of possible measles exposure at McCandless Target
NASA’s SunRISE Mission Targets No Earlier Than Mid-2027 Launch
NASA’s SunRISE (Sun Radio Interferometer Space Experiment) mission will launch no earlier than mid-2027. The heliophysics mission will hitch a ride on a
Health officials warn of possible measles exposure at McCandless Target
Fact check: Ad targets NC Democratic candidate’s donations and political ties
A PAC ad attacks U.S. congressional candidate Jamie Ager over donations and his affiliation with a former Biden administration official.
PENN Entertainment (PENN) Stock Trades Up, Here Is Why
What Happened? Shares of casino, sports betting and entertainment operator PENN Entertainment NASDAQ:PENNjumped 5.3% in the pre-market session after Deutsche Bank upgraded the company to Buy from Hold and raised its price target to $25 from $23.Deutsche Bank analyst Carlo Santarelli upgraded the sh…
Sphere Entertainment stock price target lowered to $125 by StoneX
Sphere Entertainment stock price target lowered to $125 by StoneX
FBI investigated anti-ICE protesters after Trump demanded probe over TikTok video, whistleblower alleges
The FBI opened preliminary investigations targeting anti-Immigration and Customs Enforcement protesters in Southern California, a former FBI intelligence official alleged in a whistleblower complaint, adding that she believed the move violated the law and agency policy.
"Still Looking" – Fabrizio Romano Reveals Man Utd's David Raum Stance
David Raum was mentioned as one of the potential left-back targets for Manchester United in the summer.
Walmart goes after linear TV with Warner Bros ad deal
The retail giant has struck a deal with Warner Bros. Discovery so advertisers can target Walmart shoppers on linear TV.
StoneX maintains Buy rating on Sphere Entertainment, $125 price target
StoneX maintained their Buy rating on Sphere Entertainment's stock with a price target of $125.00.The price target implies an upside of 12.8% from the Oct 5 close of $110.80.Key takeaways from the analyst noteLong-Term Growth Potential: Despite recent challenges, Sphere Entertainment is expected to…
Burglars target 5 businesses on same block in Greater Grand Crossing
Burglars targeted at least five businesses on the same block in Chicago's Greater Grand Crossing neighborhood early Monday morning.
BTIG cuts Sphere Entertainment stock price target on lower revenue outlook
BTIG cuts Sphere Entertainment stock price target on lower revenue outlook
BTIG maintains Buy rating on Sphere Entertainment, $160 price target
BTIG maintained their Buy rating on Sphere Entertainment's stock with a price target of $160.00.The price target implies an upside of 44.4% from the Oct 5 close of $110.80.Key takeaways from the analyst notePositive Long-Term Growth Potential: Sphere Entertainment is positioned uniquely in the grow…
Northwest Biotherapeutics Announces Keynote Presentation on Harnessing Immunity: A Personalized, Multi-Target Approach to Cancer At the UK National Health Service Annual Oncology Conference
/PRNewswire/ -- Northwest Biotherapeutics (OTCQB:NWBO) (the "Company" or "NWBio"), a biotechnology company developing DCVax® personalized immune therapies for...
Six Flags Entertainment Corporation (NYSE:FUN) Stock Has Average Target Price of $21.50
Six Flags Entertainment Corporation (NYSE:FUN - Get Free Report) has earned a consensus rating of "Hold" from the sixteen ratings firms that are covering the company, MarketBeat Ratings reports. Three investment analysts have rated the stock with a sell recommendation, six have issued a hold recomme
As federal grant cuts hit social sciences, McInnis ‘worried’ about funds
Yale’s federal funding declined by 1.5 percent in the last fiscal year, with cuts affecting social science fields — which the Trump administration has targeted. Yale President Maurie McInnis said last month that the government had been slow to disburse awards.
ClickFix Smuggles Payloads Through Browser Cache to Bypass Windows Run Limits
Microsoft observed ClickFix attacks using browser cache smuggling to execute cached VBScript and launch a credential-targeting malware chain.
Fantasy football IDP free-agent report: Week 5
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Relatives of Epstein victim appear in attack ad targeting Jeff Crank
Relatives of Virginia Giuffre, one of Jeffrey Epstein‘s most prominent victims, accuse U.S. Rep. Jeff Crank in a TV ad released Monday by his Democratic challenger of refusing to meet with them last year when they sought his assistance to force a vote to release federal files related to the convicted sex offender. Sky and […]
Canonsburg reviews business growth in workshop
Canonsburg officials and business leaders met last week to review the past six years of economic growth and plan for the future. The borough has seen a marked upswing in downtown business growth in recent years thanks to targeted redevelopment efforts, local business associations and a focus on diverse local events to drive customer traffic. […]
Texas voters get ‘Are you white?' political texts targeting James Talarico
Texas voters received political texts asking, “Are you white?” NBC 5 traced the website targeting James Talarico to political group AMERIPAC.
Why Sphere Entertainment (SPHR) Stock Is Trading Lower Today
Shares of content production and distribution company Sphere Entertainment (NYSE:SPHR) fell 12.3% in the afternoon session after Craig-Hallum analyst Ryan Sigdahl downgraded the stock from Buy to Hold and reduced the price target to $132 from $170. According to TipRanks, Sigdahl pointed to demand for The Wizard of Oz at Sphere fading faster than expected. The firm cut its estimates to reflect that weaker outlook and lowered its price target to $132 from $170. A reduced target on the show that ha
Key Recruiting Target Visiting Duke Basketball on Monday
The Duke Blue Devils are getting a visit from a five-star recruit in the 2028 class on Monday.
US says foreign financial institutions doing business with Iran may be sanctioned without notice
WASHINGTON, Oct 5 (Reuters) - The US Treasury Department said on Monday it was alerting foreign financial institutions that continue to do business with Iran or its financial sector that they may be sanctioned by Washington without advance notice. DETAILS: • "Foreign financial institutions continuing to transact with sanctioned Iranian financial institutions could be targeted at any time without advance notification and should take immediate action to terminate such activity and relationship
Did New Science Board Just Shift BioCryst's (BCRX) Investment Narrative?
BioCryst Pharmaceuticals recently formed a seven-member Scientific Advisory Board made up of experienced rare disease and drug development leaders to guide its research, clinical plans and regulatory approach. The depth of this board, spanning big pharma R&D, AI driven drug discovery and rare disease commercialization, directly targets BioCryst’s execution risk as it builds a broader pipeline beyond its current portfolio. We will now examine how BioCryst Pharmaceuticals’ investment narrative...
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Viral Dallas mansion gets political with this year's Halloween display
A Preston Hollow mansion known for viral holiday displays has unveiled a political Halloween display that backs Ken Paxton, targets James Talarico and calls out Dallas Councilwoman Gay Donnell Willis.
CD Projekt Promises 'The Witcher 3' Remaster Fixes as Some Players Struggle
An upcoming patch will target performance issues
Democrats expand target list as polls point in their favor
Democrats are expanding the number of Republican-held House seats they hope to flip in November as polling moves in their favor ahead of the midterm elections. The Democratic Congressional Campaign Committee announced Monday that it added six candidates to its “Red to Blue” program, bringing the total to 46. The program provides candidates with strategic […]
Pat Bryant catches all three targets
Denver Broncos WR Pat Bryant (ankle) caught all three of his targets for 47 yards in Week 4 before exiting with an ankle injury.
Courtland Sutton with another dreadful day
Denver Broncos WR Courtland Sutton had just one catch for four yards on six targets in Week 4.
GTA VI Writers Sidestep Trump and MAGA, as Rockstar’s Rupert Humphries Says Florida Satire Targets Conspiracy Theories Instead
Rockstar said there won't be any references to specific trends or persons in GTA VI, as the game focuses on stuff like conspiracy theories.
Should Aging Be Called a Disease? Scientists Are Rethinking What It Means to Grow Older
What if the next big target in medicine is getting older itself? Researchers are taking that possibility seriously, with new tools, new clinics, and growing FDA attention. Instead of waiting for diabe...
Some mental health providers hoping to serve Lane County's Oregon Health Plan members say they’re facing barriers
Aspire is one of a few healthcare providers in Lane County that told KLCC they want to – but haven’t been able to – get a contract with Lane County's Medicaid insurer Trillium. That’s left Aspire without access to its target population, and other providers considering scaling back their services.
DraftKings Rallies 5% as BoA Upgrades to Buy With $27 Price Target; Flutter Entertainment Ticks Up
A Wall Street firm that spent the past year avoiding DraftKings (NASDAQ:DKNG | DKNG Price Prediction) over prediction-market risk has lifted its view. DraftKings stock is up 5% to $19.46 in morning trading after Bank of America (NYSE:BAC) upgraded the shares to Buy from Neutral. Also, shares of Flutter Entertainment (NYSE:FLUT) are up 1%, a […]
Tracking health misinformation helps pediatricians provide targeted patient education
Pediatric clinicians can learn useful information by tracking the health misinformation that their patients encounter, according to research presented during the American Academy of Pediatrics 2026 National Conference & Exhibition Oct. 2-6, 2026, at the San Diego Convention Center.
Duke Recruiting: Crystal Balls For A Five-Star Target
Are things looking good for Asa Montgomery to Duke?
Innovation That Solves: From Business Needs to AI Solutions
Targeted AI innovation transforms business challenges like hydrocarbon compliance into effective technological solutions, writes Jorge Mandujano.
MobileFuse Receives SBTi Validation for Its Science-Based Emissions Target
/PRNewswire/ -- MobileFuse, a leading advertising and technology platform, today announced that SBTi Services validated its science-based greenhouse gas...
The science behind targeted oral peptides
A new type of medication is tackling a problem that has long frustrated drug developers: how to deliver peptide therapies orally and hit their target more precisely.
Cybersecurity portal to fight bad guys open for business: NMFTA
The NMFTA has launched its threat portal, where targets of successful and unsuccessful cyberattacks can share their stories.
Jobs in health care. Jobs for women. The US labour market is segmenting. Chernobyl’s radiation and Lenin’s love of literature.
Thank you for opening your Chartbook email. Elmer Bischoff, Two Figures at the Seashore, 1957 The only really dynamic job-creator in the US economy is health care: The largest crunch has come in Federal government, which has shed 2.7 m jobs. Source: tchouvkov on Twitter Tech is struggling. [ Joey Politano 🏳️🌈@JosephPolitano The US tech sector continues bleeding jobs in official data released today—overall, employment decreased by 17k last month and is down 69k over the last year That's nearly as bad as the worst of the 2024 tech-cession, and much worse than the 2022 boom or even pre-2020 norms 12:42 PM · Oct 2, 2026 · 15.2K Views 15 Replies · 47 Reposts · 390 Likes ](https://x.com/JosephPolitano/status/2106001807847940232?s=20) The new jobs are all for women. [ Justin Wolfers@JustinWolfers I'm not sure who saw this coming, but so far nearly all the jobs created during the second Trump administration have gone to women. 1:09 PM · Oct 2, 2026 · 33K Views 70 Replies · 146 Reposts · 644 Likes ](https://x.com/JustinWolfers/status/2106008723533533601?s=20) Meanwhile, real wages are being eaten up by modest over-target inflation. [ Heather Long@byHeatherLong The financial pain is real: Wage growth fell to 3% (y/y) in September. That's the lowest in 5 years. Wage growth: 3% Inflation: ~3.4% Inflation has eaten up all wage gains for the average worker since April. Many people are having to make hard choices about what to buy and what … 1:24 PM · Oct 2, 2026 · 37K Views 24 Replies · 275 Reposts · 533 Likes ](https://x.com/byHeatherLong/status/2106012367712620728?s=20) HEY READERS, THANK YOU for opening the Chartbook email. I hope it brightens your day. I enjoy putting out the newsletter, but tbh, what keeps this flow going is the generosity of those readers who clicked the subscription button. If you are persuaded to click, please consider the annual subscription of $60. It is both better value for you and a much better deal for me, as it involves only one credit card charge. Why feed the payments companies if we don’t have to. Subscribe Elmer Bischoff, Bathers, 1960 Americans are disillusioned with higher ed. For contributing subscribers only. Subscribe Where the Chernobyl radiation went. h/t Simon Kuestenmacher aka simongerman600 How Lenin’s love of literature shaped the Russian Revolution - Tariq Ali This, then, was the intellectual atmosphere in which Lenin came of age. His father, a highly cultured conservative, was the chief inspector of schools in his region and much respected as an educationalist. At home, Shakespeare, Goethe and Pushkin, among others, were read aloud on Sunday afternoons. It was impossible for the Ulyanov family – “Lenin” was a pseudonym adopted to outwit the tsarist secret police – to escape high culture. At high school, Lenin fell in love with Latin. His headteacher had high hopes that he might become a philologist and Latin scholar. History willed otherwise, but Lenin’s passion for Latin, and taste for the classics, never left him. He read Virgil, Ovid, Horace and Juvenal in the original, as well as Roman senatorial orations. He devoured Goethe during his two decades in exile, reading and rereading Faust many times. Lenin put his knowledge of the classics to good use in the time leading up to the October revolution of 1917. In April of that year, he broke with Russian social-democratic orthodoxy and, in a set of radical theses, called for a socialist revolution in Russia. A number of his own close comrades denounced him. In a sharp riposte, Lenin quoted Mephistopheles from Goethe’s masterwork: “Theory, my friend, is grey, but green is the eternal tree of life.” Source: The Guardian Elmer Bischoff, The River, 1953 If you’ve scrolled this far, you know you want to click: Subscribe
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Rethinking discovery: how powerful screening tools are redefining the search for new medicines
In medicine discovery, identifying the right biological target has always been a critical and complex step. Today, the rise of powerful screening tools is fundamentally reshaping this process, creating a step-change in how we move from scientific hypotheses to transformative medicines. Advances in high-throughput screening, genomics and AI-driven analytics are enabling scientists to interrogate disease biology at unprecedented scale, bringing forward opportunities that were previously beyond reach.
Republicans and Democrats find a unifying target: Pharmacy benefit managers
Republicans and Democrats, both patients and politicians, seem united in their disdain for the healthcare companies known as pharmacy benefit managers. Tennessee and Arkansas are regulating them now.
IRGC General Warns Regional States against Letting US Use Their Territory
TEHRAN (Tasnim) – Brigadier General Ali Fadavi warned regional countries against allowing the US to employ their territories for operations against Iran, stressing that any location used as a launch point for attacks on Iran will be targeted.
Trump takes extraordinary steps to target midterms, alarming critics
Trump's election moves include a redistricting push, seeking to restrict voting and floating a $5,000 payment to every American adult if the GOP wins.
Real Madrid set to join the race for Alex Scott
Real Madrid are considering a move for Bournemouth midfielder Alex Scott after stepping up their scouting of the England international.The 23-year-old has emerged as a target for several major clubs, ...