SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " gem " 3,842 found 🔀 AI-powered Shuffle
Zinedine Zidane has agreement in place to return to management
Without naming names, President of the French Football Federation (FFF) Philippe Diallo came close to confirming what has been an open secret for some time. Zinedine Zidane is closing in on his long-a...
Invincible VS adds Conquest; DLC characters Universa and the Immortal announced
Conquest will be the final of 18 playable characters available at launch in three-versus-three tag fighting game Invincible VS, publisher Skybound Games and developer Quarter Up announced. Addition…
Lamar University unveils new doctoral energy management program
Lamar University unveils new doctoral energy program to facilitate advanced academic research in local sector.
Avatar Legends: The Fighting Game launches July 2
Avatar Legends: The Fighting Game will launch for PlayStation 5, Xbox Series, Switch 2, Switch, and PC via Steam on July 2, Gameplay Group announced. PC pre-orders are available now. PlayStation St…
Local Newspaper Erodes Community Civic Fabric
The Hawk Eye, Burlington, Iowa's local newspaper, recounts its decline from a community-rooted newsroom that covered a major 1987 grain-elevator explosion to a diminished operation today. Now owned by Gannett after GateHouse consolidation, the paper prints six days a week with only three reporters, outsources layout and printing, and runs syndicated content instead of local reporting. The loss of routine local coverage has eroded civic engagement and community ties.
Polar bears are struggling in every aspect of their lives, but scientists are hoping to prevent extinction through genetic management
Polar bears are struggling to survive as Arctic ice disappears, limiting food, reducing habitat, and pushing their ability to adapt.
Colorado Politics Calendar Mar. 30-Apr. 5
CoPo’s weekly political calendar will help you find political and public-policy events throughout Colorado. It includes candidate and issue campaign events, public policy meetings, court hearings, state and local party conventions, assemblies, debates, rallies, parades, speaking engagements, traveling dignitary appearances, water meetings, book signings, county commission hearings, city council meetings and more. As a subscriber, […]
The experimental drug transforming weight loss, retatrutide
Here’s how retatrutide works and how it differs from existing weight management medications.
New rage room business in Topeka offers space to break items, relieve stress
Anger Management 785 will join spaces with Odin’s Lair and allow patrons to use bats, clubs and hammers to break objects.
Gemini redesigning glow on Android, rolls out free Personal Intelligence & Memory
Google has a few other Gemini app updates, starting with Personal Intelligence seeing wide US availability.
Q&A: Tariff uncertainty far from over for Michigan businesses
‘We’re in another period of great uncertainty, whether one supports the tariffs or not,’ said Christopher Padilla, former Under Secretary of Commerce for International Trade under President George W. Bush.
The two Taylor Lautners are expecting a baby Lautner soon
Taylor Lautner and his wife, Tay, are expecting their first baby. The 'Twilight' actor married the former Taylor Dome in 2022 after a one-year engagement.
Apple Sends Lock Screen Alerts to Outdated iPhones Over Active Web-Based Exploits
Apple issues Lock Screen alerts after Coruna and DarkSword exploit kits target iOS 13.0–18.7, increasing web-based attack risks.
Macomb city officials break down proposed sports complex, residents voice concerns
A crowd of about 100 people gathered at Thursday evening's economic development update.
CNA nurses demand UCI Health-Fountain Valley reopen pediatric units that serve hundreds of children annually
Registered nurses at UCI Health-Fountain Valley in Fountain Valley, Calif., are demanding that management immediately reopen the pediatric department and pediatric intensive care unit (PICU), which were closed without warning on Monday, March 23.
Ashley Benson Signs With Strand Entertainment (EXCLUSIVE)
Ashley Benson has inked with Strand Entertainment for management. She continues to be repped by IAG and Hansen, Jacobson, Teller.
Ashley Benson Signs With Strand Entertainment
EXCLUSIVE: Strand Entertainment has signed Ashley Benson, an actress and producer whose work spans studio features, independent film, and television, for management. Benson was most recently seen star...
Firetruck crashes into Quincy native’s Nashville business
A firefighter is recovering after crashing a fire engine into a Nashville chiropractic clinic owned by Quincy native Kevin Bradshaw.
Blue Reflection Quartet announced for PS5, Switch 2, Switch, and PC
Publisher Koei Tecmo and developer Gust have announced Blue Reflection series collection Blue Reflection Quartet for PlayStation 5, Switch 2, Switch, and PC (Steam). It will launch on July 30 world…
Super Meat Boy 3D physical editions announced for PS5, Switch 2
Meridiem will release physical editions of Headup-published and Sluggerfly- and Team Meat-developed 3D platformer Super Meat Boy 3D for PlayStation 5 and Switch 2, the distributor announced. They w…
A grassroots initiative connects Clemson scientists across ecology and evolution
Faculty-led initiative seeks to break down silos and strengthen research, teaching and student engagement.
Sick of empty VR app stores? Google's new AI tool lets you build VR apps in under a minute
Gemini's new Vibe Coding XR could finally solve the Android XR content problem.
Citrus County Chamber calls out 'optics' of Jeff Kottkamp's appearance with CFO
'Public statements suggesting mismanagement, without full context, risk undermining community trust'
Gemini takes on ChatGPT and Claude with a major switching upgrade
Easily import your memories and preferences
Exclusive: Anthropic left details of an unreleased model, exclusive CEO retreat, sitting in an unsecured data trove in a significant security lapse
In a significant security lapse, the not-yet-public information was made accessible via the company’s content management system
You can now transfer your chats and personal information from other chatbots directly into Gemini
Google is launching "switching tools" that, just as it sounds, will make it easier for users of other chatbots to switch to Gemini.
Google Translate Gets Gemini AI for Smarter Translations and Real-Time Headphone Translation
Google is improving its translation features with Gemini integration, adding AI in search and the Google Translate app. Users can expect smarter and more natural text translations, with improvements to phrases with nuanced meanings. Idioms, local expressions, and slang will be translated with Gemini for improved accuracy, and Gemini will parse context instead of giving a literal word-for-word translation.
Rajendra: In sports, there's more to winning than the scoreboard
Sports fans can transform their experience from passive consumption to mindful engagement, even amid the rise of sports betting.
Google Gemini now lets you import your chats and data from other AI apps
Google is adding a pair of new features to Gemini aimed at making it easier to switch to the AI chatbot.
Suffolk town supervisors, on business panel, discuss what lies ahead
Waste management, sewers, housing stock, and an expanded MacArthur airport all were topics of discussion Thursday at the HIA-LI event.
Google is making it easier to import another AI’s memory into Gemini
Prompt your AI to copy-paste its memory into Gemini.
Apple will reportedly allow other AI chatbots to plug into Siri
Other AI chatbots, like Gemini or Claude, could help Siri fetch answers.
Google Gemini Adds Tool to Make It Easier to Switch from ChatGPT
Google released new tools for its Gemini artificial intelligence assistant that will let users upload chat history and context from other AI apps, a move to lure users from rivals like OpenAI’s ChatGPT and Anthropic PBC’s Claude.
Google Search Live expands globally where AI Mode is available
Google credits its new audio and voice models in Gemini 3.1 Flash Live for the expansion.
Gemini now lets you import chats and memory from other AI apps
Besides Gemini 3.1 Flash Live today, Google is rolling out the ability to import memory and chats into Gemini from other AI apps.
Apple Plans to Let Rival AI Chatbots Integrate With Siri in iOS 27
Apple plans to allow third-party AI chatbots to integrate with Siri in iOS 27, reports Bloomberg. Apple already has a partnership with OpenAI that lets Siri hand questions off to ChatGPT, but Apple will expand that integration to other companies like Google and Anthropic. An iPhone user with the Claude or Gemini app installed will be able to send questions to those chatbots, like how the current ChatGPT feature works.
Search Live rolling out globally as Google Translate’s live headphones mode comes to iPhone
With the launch of Gemini 3.1 Flash Live, Google is launching Search Live globally. Meanwhile, Google Translate's new headphones...
CSU Extension offers Ag Business Management workshop
Learn to create an enterprise analysis for alfalfa, barley, potatoes, quinoa, cow calf and forage cover crops
Bluey’s Happy Snaps announced for PS5, Xbox Series, Switch 2, PS4, Xbox One, Switch, and PC
Publisher Gameloft and developer Gameloft Brisbane have announced Bluey’s Happy Snap for PlayStation 5, Xbox Series, Switch 2, PlayStation 4, Xbox One, Switch, and PC (Steam, Epic Games Store…
Hunter: The Reckoning – Deathwish announced for PS5, Xbox Series, and PC
Publisher Nacon and developer Teyon have announced Hunter: The Reckoning – Deathwish for PlayStation 5, Xbox Series, and PC (Steam, Microsoft Store). It will launch in summer 2027. It will al…
Lynn sports management students attend National Football League Combine
Lynn University sports management students attended the Sports Management Worldwide National Football League (NFL) Combine Football Career Conference in…
2025 American Association for the Advancement of Science (AAAS) Fellow
Department Chair, Professor Alexander Spokoyny has been selected as a 2025 Fellow of the American Association for the Advancement of Science (AAAS) in recognition of his distinguished contributions in main group and organometallic chemistry and academic community engagement and leadership. AAAS is the world’s largest general-scientific society and publisher of the journal Science. Spokoyny is among the 449 scientists, engineers, and innovators spanning 24 scientific disciplines who are being recognized for their scientifically and socially distinguished achievements. Four of the new fellows are UCLA faculty members. The new Fellows will be celebrated in Washington, D.C., in late May 2026. Read more about the new AAAS Fellows here. AAAS Fellows in the UCLA Department of Chemistry & Biochemistry are Professors Kendall Houk (1988), Paul Weiss (1999), Richard Kaner (2000), David Eisenberg and Todd Yeates (2001), Juli Feigon (2002), Miguel Garcia-Garibay and Steven Clarke (2007), Heather Maynard, Carla Koehler, Xiangfeng Duan and Neil Garg (2018), Paula Diaconescu and Thomas Mason (2019), Joseph Loo (2021), and Yi Tang (2022). Penny Jennings, UCLA Department of Chemistry & Biochemistry, penjen@g.ucla.edu.
Teens and screens
WFU’s Center for Literacy Education explores the intersections of teen digital literacy, brain health, and intentional engagement in a 96% online world.
Callodine Specialty Income Fund Adds Entertainment Lending and Aviation Finance Strategies
Callodine Group (“Callodine” or the “Company”) is pleased to announce the addition of Corrum Capital Management (“Corrum Capital”) as a sub-advisor to the Ca...
MLB Opening Night: Yankees thump Giants behind Max Fried's gem for fifth straight season-opening win
Rio Tinto Calls Time on Diamond Business as Last Mine Closes
Rio Tinto Group has dug its last diamond and will close its final mine for the precious gemstone, marking the end of a business that lasted more than half a century.
Augmenting citizen science with computer vision for fish monitoring
Monitoring river herring migration is essential for conservation and fisheries management. Researchers have now demonstrated a method using video and computer vision to supplement traditional methods and volunteer-based programs.
Brenmiller Energy Issues Business Update Highlighting Commercial Breakthrough, First TES Revenue and BNRG360 Growth Strategy
Delivered flagship Tempo project, Brenmiller's first commercial-scale boiler replacement deployment, marking a major operational milestone in the Company's transition toward commercializationRecognized first revenue from a TES system sale, validating Brenmiller's ability to convert project execution into reported revenueEntering 2026 with previously disclosed projected 2026 revenue of approximately $1.7 million tied to Tempo execution milestones, which management believes reflects the beginning.
Michigan measles outbreak: Confirmed cases grow to seven, including child under 5
The Washtenaw County outbreak has seven confirmed cases and one hospitalization. Officials are asking that anyone unvaccinated or not already immune to measles stay away from others for a full 21 days after exposure.
Some East Grand Forks businesses must register with city to sell low-potency hemp products
Changes in requirements from the state Office of Cannabis Management mean businesses selling these products must now be licensed with the OCM and registered with their local cities.
Domain Capital Group Closes $768 Million In Commitments For Domain Entertainment Fund II
Domain Capital Group LLC, a private investment management firm, and its subsidiary Domain Capital [...]
Can Lifestyle Changes Over a Lifetime Protect Brain Health?
University of Miami researchers link long‑term exercise, diet, and social engagement to better cognition with aging.
Google launches Lyria 3 Pro music generation model
Google is launching Lyria 3 Pro, an upgraded music model that generates longer, more customizable tracks, as it expands AI music tools across Gemini, enterprise products, and other services.
Supreme Court says that internet service provider isn’t liable for bootlegged music downloads
In a major loss for the nation’s music industry, the Supreme Court on Wednesday ruled that a major internet service provider is not liable for copyright infringement because it failed to kick known copyright violators off its network.
New details on Apple-Google AI deal revealed, including Gemini changes: report
A new report goes behind-the-scenes on Apple’s AI deal with Google, control of Gemini-based models, model distillation, and more.
Amusement Entertainment Management Client Wins 2026 FEC of the Year
Star Lanes Polaris of Columbus, Ohio proudly accepted The American Amusement Machine Association’s (AAMA) 2026 Family Entertainment Center Location of the Year Award during the AAMA President…
Supreme Court tosses $1B copyright verdict in record companies' battle over illegal internet downloads
The Supreme Court unanimously ruled Wednesday that internet providers are not liable for copyright infringement by their users, delivering an opinion in Cox v. Sony and tossing a $1 billion verdict.
Jaguars Cut Ribbon on New Business Headquarters at One Tower Court
Downtown’s Newest Class-A Office Building Also Celebrates Opening for Downtown YMCA Branch, Announces Timucuan Asset Management and Foley & Lardner LLP as Tenants
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Domain Capital Group Closes $768 Million in Commitments for Domain Entertainment Fund II
ATLANTA, March 25, 2026--Domain Capital Group LLC, a private investment management firm, and its subsidiary Domain Capital Advisors LLC, today announced the closing of $768 million in equity commitments for its second entertainment fund and its affiliates.
Cardinal Health (CAH) Emerged as a Key Contributor on Pharmaceutical Strength and Margin Expansion
Renaissance Investment Management, an investment management company, released its Q4 2025 “Large Cap Growth Strategy” investor letter. A copy of the letter can be downloaded here. The strategy faced a difficult fourth quarter of 2025, underperforming both the S&P 500, which gained 2.7%, and the Russell 1000 Growth Index as market leadership remained concentrated in […]
Exclusive | Domain Capital Raises $768 Million Fund to Tap Surging Entertainment Demand
The firm is expanding its entertainment investments with a new artist-management venture and financing agreements with major studios.
Deloitte: From Subscribers to Superfans: Fan Engagement Shapes the Next Phase of Media and Entertainment Growth
/PRNewswire/ -- Key takeaways Consumer spend remains flat on streaming services: The average subscribing household reports spending $69 per month on streaming...
Sonic Frontiers Definitive Edition rated in Korea
The Game Rating and Administration Committee of Korea has rated the unannounced Sonic Frontiers Definitive Edition.
Crystal Festival brings sparkle, science, and family fun to Mt. Pleasant
MT. PLEASANT — A weekend filled with discovery, creativity, and hands-on fun is coming to Sanpete County as the Crystal Festival returns this spring with an exciting lineup of activities for all ages. The Crystal Festival — A Rocks, Minerals, Gems, & Crystal Show — will take place April 4–5, 2026, at the Mt Pleasant […]
ICE presence rising at Michigan health care facilities, rights groups say
The Michigan Immigrant Rights Center and the ACLU of Michigan have sent guidance to more than 400 hospitals and providers in the state to outline law enforcement changes to ‘sensitive locations’ policy.
Google TV's new Gemini features keep fans updated on sports teams and more
Three Gemini-powered features are coming to your Google TV. This includes visual responses, deep dives, and sports briefs.
Episode 68, Science for Success, Tissue testing and Potassium
By Dusty Sonnenberg, CCA, Field Leader, a project of the Ohio Soybean Council and Soybean Check-off In Episode 68, Dusty visits with soybean researchers involved in the Science for Success program. Science for Success provides timely, cutting-edge best management practices by coordinating the uni
UMaine sports management students enjoy networking trip to Indiana
Westfield’s Droplight Grand Park Sports Campus, more Indianapolis-based experiences
Epic Games cuts 1,000 jobs as Fortnite 'magic' fades in 'extreme' market conditions
Epic Games is laying off over 1,000 employees as CEO Tim Sweeney cites declining Fortnite engagement and spending that exceeds the company's revenue.
Epic Games cuts 1,000 jobs as Fortnite 'magic' fades in 'extreme' market conditions
Epic Games is laying off over 1,000 employees as CEO Tim Sweeney cites declining Fortnite engagement and spending that exceeds the company's revenue.
Three new Gemini features come to Google TV
AI-powered visual help, deep dives and sports briefs arrive in the US.
Epic Games to Layoff 1,000 and Cut $500 Million Amid 'Fortnite' Slump
Epic Games will cut 1,000 staffers and another $500 million in costs amid a slump in engagement with 'Fortnite,' CEO Tim Sweeney confirmed in a memo.
Epic Games cuts 1000 jobs, says Fortnite engagement is down
Epic Games also increased the price of V-Bucks, the Fortnite in-game currency.
Epic Games lays off over 1,000 employees following "downturn in Fortnite engagement"
CEO Tim Sweeney says cuts are necessary to "keep the company funded" and to put it "in a more stable place"
Apple takes aim at Google Workspace and Microsoft 365 with new hosted business email
The new Apple Business platform is expanding beyond device management. It now includes fully integrated email, calendar, and directory services for business domain.
Apple Business Essentials goes free as Apple merges enterprise tools into Apple Business
Apple is offering Apple Business Essentials for free as it merges device management, branding tools, and support under the new Apple Business platform.
Fortnite Maker Epic Games Cuts About 1,000 Jobs Across Company
The company is seeing a downturn in engagement on Fortnite
Ice In New Orleans, Floods In Los Angeles: Businesses’ Risk Reality
Extreme weather is reshaping business risk management, from billion‑dollar storm losses to unexpected climate events that disrupt operations.
From data to culture: Baptist Health’s well-being journey
A defining moment became a catalyst as Baptist Health strengthened leadership engagement, secured local champions to expand physician support across Kentucky.
Clean your feed: Avoid the YouTube slop
YouTube is packed with engagement bait and AI videos
From One Major to Three in Four Years: Connecting Data Science, German and Linguistics at Montclair
In a German language program for local children and on an archive translation project, Isabella Zarate Gonzalez shows how Montclair’s mix of STEM, world languages and community engagement helped her connect her interests into a single path
How can you explore careers worldwide? Binghamton student founds club to find out
Binghamton University School of Management student Liam Foley discovers how connecting with diverse cultures creates new pathways for success after founding an international business club.
NIU Today - Two business graduate degrees reimagined with a bold AI focus
Beginning this fall, two graduate degrees within the College of Business’s Department of Operations Management and Information Systems (OM&IS) will be reimagined to emphasize their focus on artificial intelligence and analytics. Formerly known as the Master of Science in Data Analytics (MSDA) degree, this degree has been transformed into the Master of Science in Business...
Stephanie Laing Signs With Linden Entertainment For Management (EXCLUSIVE)
Director Stephanie Laing has inked with Linden Entertainment for Management. She remains repped by CAA and Myman Greenspan.
Linden Entertainment Signs ‘Your Friends & Neighbors’, ‘Tow’ Director Stephanie Laing
EXCLUSIVE: Linden Entertainment has signed Emmy-winning director, writer, and producer Stephanie Laing for management. Laing is coming off the theatrical release of her new film, Tow, a comedy-drama s...
I go to Florida often; favorite destination is quiet, lesser-known
I grew up visiting family in Fort Pierce, Florida, and I think of this beach city as a hidden gem. The beaches are relatively uncrowded and beautiful.
Stealth BioTherapeutics Announces MRC Business Engagement Fund Grant to Advance Mitochondrial Disease Research
/PRNewswire/ -- Stealth BioTherapeutics (the "Company"), a commercial-stage biotechnology company focused on the discovery, development, and commercialization...
PATLABOR the Case Files announced for PS5, PC
Publisher Good Smile Company and developer Chime Corporation have announced 3D action game PATLABOR the Case Files
'ET's' archive has William Shatner on a whale and a young Taylor Swift
'Entertainment Tonight' is digitizing and preserving its archive of 45 years of interview set visits and red carpet walks, which include gems like George Clooney's first interview.
Microsoft Plans Better Windows 11 RAM Management and a Smoother User Experience
Microsoft recently announced a plethora of changes coming to Windows 11 to reshape the operating system into a completely stable and enjoyable experience. Today we learn that Microsoft plans a major background usage overhaul with future updates, focusing on RAM usage and overall memory management, s...
Why the BTS Comeback Concert Was a ‘Disaster’ for Some Businesses
The turnout for the K-pop titans’ show was much lower than projected by officials, hitting the bottom line of some restaurants. Shares in the group’s management company also fell.
Rising job opportunities in sports management attract students
Kaleb Tkacs became involved in sports management from the moment he stepped foot on Duquesne University’s campus in August 2023. Tkacs, of Scottdale, joined as a volunteer film crew member with the Duquesne football team that fall. In 2024, he was elevated as a student assistant, overseeing the film crew,
I tested ChatGPT vs. Perplexity with the same 5 prompts — the winner surprised me
AI Madness Round 1: The Heavyweight meets the Challenger in our first round of Tom's Guide AI Madness
Binghamton ranked No. 1 public business school in New York state
The Binghamton University School of Management jumped ahead in the prominent Best Undergraduate Business Schools of 2026 ranking by Poets & Quants, placing No. 1 among New York state’s public business schools.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
PICROSS S KONAMI ANTIQUES edition announced for Switch
Jupiter has announced PICROSS S KONAMI ANTIQUES edition for Switch. It will launch via Nintendo eShop on April 30 for $17.99 / €17.99 / £16.19 / ¥1,800.
Square Enix announces it will integrate Google’s generative AI Gemini into popular online game Dragon Quest X
Square Enix has found a use for Google’s generative AI Gemini and will be putting it to use in the popular online game, Dragon Quest X. Gemini will be used in-game as a feature that allows players to…
Guilty Gear: Strive version 2.00 update, Season 5 DLC characters Jam Kuradoberi and Robo=Ky announced
Arc System Works has announced the version 2.00 update for fighting game Guilty Gear: Strive, which will launch on April 9 alongside Season 5 downloadable content character Jam Kuradoberi.
Bloodstained: The Scarlet Engagement listed for Nintendo Switch, plus an unannounced 505 Games Switch 2 title
Bloodstained: The Scarlet Engagement has been listed for Nintendo Switch alongside an unannounced Switch 2 title from 505 Games. The Scarlet Engagement, a sequel to the original, was previously announced last year. Although there wasn’t any news about a Nintendo release, the latest discovery suggests that we’ll be getting it on Switch at the very least. It’d be somewhat surprising...