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A Challenge for ‘No Kings’ Protests, the Third Time Around
Organizers want this to be largest protest yet. But is hitting a number enough to deliver an effective political movement?
Minnesota serves as the flagship for nationwide 'No Kings' protests against Trump
Organizers of Saturday’s “No Kings” demonstrations across the country predict Saturday’s rallies against President Donald Trump could add up to one of the largest protests in U.S. history
The cockfighting business on the border: Illegal breeding farms in the US and birds sold for thousands of dollars to cartels in Mexico
An investigation by two NGOs indicates that some of the main breeders of fighting birds have operations in both countries and supply hundreds of thousands of specimens to criminal organizations each year
At CPAC, the ‘America First’ crowd ponders giving war a chance
The Conservative Political Action Conference has been an America First gathering for years, but with President Trump pursuing war in Iran, organizers have tried to make a shift, with mixed results.
At CPAC, the ‘America First’ Crowd Ponders Giving War a Chance
The Conservative Political Action Conference has been an America First gathering for years, but with President Trump pursuing war in Iran, organizers have tried to make a shift, with mixed results.
‘Families not Politics’ coalition launches to oppose Colorado ballot measures targeting transgender minors
Advocacy organizations in Colorado have launched a campaign opposing two November ballot measures that would regulate transgender minors’ participation in school sports and access to certain medical procedures, setting the stage for a statewide debate over youth policy and parental decision‑making. Dubbed “Families Not Politics,” the coalition was established to “defend the freedoms, privacy, and […]
Everything You Missed at Shop TODAY Stages 2026 Health & Wellness Summit
Guests enjoyed a day full of expert chats, pampering and, of course, plenty of free products.
PVM Scholars Recognized at Purdue One Health and Well-Being Research Event
Purdue University’s recent One Health and Well-Being Research Event: A Celebration of Interdisciplinary Health Research, put the spotlight on several scholars in the College of Veterinary Medicine. The one-day event was organized by the College of Health and Human Sciences in partnership with sever
Some Slidell residents say defects in D.R. Horton homes are leading to health issues
At a meeting in Slidell organized by Louisiana United International and Concerned Citizens of St. Tammany, owners of D.R. homes in Lakeshore Village raised health concerns.
World Health Organization tracking new COVID variant, found in more than 20 states
The World Health Organization is tracking a new COVID variant, known as Cicada
Vanderbilt Lung Transplant Program sets new record
The Vanderbilt Transplant Center is now the second largest lung transplant center in the United States by volume, with 149 lung transplants in 2025, the most ever in one year at Vanderbilt Health. The Vanderbilt Lung Transplant Program leads the nation in organ preservation and regeneration and is among the best in long-term outcomes, demonstrating the success of the interdisciplinary team in caring for these complex patients. Several features make the program unique in the United States, said Konrad Hoetzenecker, MD, PhD, professor of Thoracic Surgery and surgical director of the Vanderbilt Lung Transplant Program. Vanderbilt serves as a “second opinion center” and accepts most complex candidates that are turned down by other centers due to increased perioperative risk. This includes patients over 70 years old, patients requiring combined procedures with their transplant, multiorgan transplantations and sensitized patients (individuals who have pre-formed anti-HLA antibodies who are at higher risk for complications). The expertise and excellent outcomes have attracted patients far beyond the borders of Tennessee; almost half of Vanderbilt Health’s lung transplant recipients come from out of state. “Another unique feature is our minimally invasive transplant program,” Hoetzenecker said. “By using distinct surgical instruments and techniques, the incisions can be kept as small as 7 to 8 centimeters, which results in better healing, less pain and faster recovery. “This minimally invasive approach is embedded in an Enhanced Recovery After Surgery (ERAS) protocol, a multimodal, evidence-based perioperative care pathway designed to reduce surgical stress, minimize complications and speed up recovery. Our unique ERAS protocol, by a dedicated interdisciplinary approach, aims to improve recovery after lung transplant and reduce ICU and hospital stay.” The lung transplant program recently celebrated a milestone — 1,000 lung transplants since the program began in 1990. “This significant achievement reflects the concerted effort of a multidisciplinary collaboration by the Departments of Thoracic Surgery, Medicine, Anesthesiology and Critical Care,” said David Erasmus, MD, associate professor of Medicine and medical director of Vanderbilt Lung Transplant. Lung transplants have been attempted since the 1960s, but they were largely unsuccessful until the 1980s, when surgical techniques were refined and new antirejection drugs proved effective. Patient outcomes steadily improved from the 1990s to the present. Vanderbilt’s fourth lung transplant recipient in 1990, Pam Everett, is the longest-living, single-lung transplant known in the world, recently celebrating 35 years since her transplant. The Vanderbilt Lung Transplant surgical team is led by Hoetzenecker and Caitlin Demarest, MD, PhD, the surgical director and associate surgical director of the Vanderbilt Lung Transplant program. Erasmus is the medical director of Vanderbilt Lung Transplant along with Anil Trindade, MD, associate medical director and associate professor of Medicine.
Jewish Family Service provides holistic care at new Addison location
The goal of the organization based in Addison is to provide holistic care and help people become healthier in every aspect.
Colorado Springs business groups launch new networking initiative to help local business owners succeed
Local organizations are teaming up to host "4-Business After Hours," a series of events designed to connect business owners and provide resources for success in the Pikes Peak region.
KDE, Kentucky Science Center to host Day of Science for Community-Based Educators in May
The Kentucky Department of Education is hosting a Day of Science Learning for Community Based Educators on May 7 from 9 a.m. to 4 p.m. ET at the Kentucky Science Center in Louisville. The event is mainly for organizations who provide science learning experiences for students outside the classroom. Attendees will learn about high-quality instructional resources
Opioid settlement funds designated to build 60-bed youth behavioral health facility in Anderson
The local nonprofit Family Dynamics Resource Center asked the county board for $2 million as a community match in order to receive $25 million dollars in funding from the state. The funds are intended to allow the organization, which provides counseling and parenting services, to develop a 60-bed behavioral health campus for youth.
JPMorgan issues new goals for engineers to boost productivity with AI
Internal JPMorgan documents reviewed by Business Insider spell out the goals software engineers are expected to meet using the firm's AI tools.
Health influencers talk social media and mental health
In this week's STATus Report, influential health communicators Jessica Knurick, Morgan “Dr. Noc” McSweeney, and Jessica Malaty Rivera chat about the mental health impacts of social media.
One Roof Sports & Entertainment ready to make NBA Seattle bid after league vote
The wait remains to see if other groups will get involved in the pursuit of an NBA franchise in Seattle, but the only organization to express its intent so far is ready for whatever the next steps call for.
2025 American Association for the Advancement of Science (AAAS) Fellow
Department Chair, Professor Alexander Spokoyny has been selected as a 2025 Fellow of the American Association for the Advancement of Science (AAAS) in recognition of his distinguished contributions in main group and organometallic chemistry and academic community engagement and leadership. AAAS is the world’s largest general-scientific society and publisher of the journal Science. Spokoyny is among the 449 scientists, engineers, and innovators spanning 24 scientific disciplines who are being recognized for their scientifically and socially distinguished achievements. Four of the new fellows are UCLA faculty members. The new Fellows will be celebrated in Washington, D.C., in late May 2026. Read more about the new AAAS Fellows here. AAAS Fellows in the UCLA Department of Chemistry & Biochemistry are Professors Kendall Houk (1988), Paul Weiss (1999), Richard Kaner (2000), David Eisenberg and Todd Yeates (2001), Juli Feigon (2002), Miguel Garcia-Garibay and Steven Clarke (2007), Heather Maynard, Carla Koehler, Xiangfeng Duan and Neil Garg (2018), Paula Diaconescu and Thomas Mason (2019), Joseph Loo (2021), and Yi Tang (2022). Penny Jennings, UCLA Department of Chemistry & Biochemistry, penjen@g.ucla.edu.
Young people find mental health support in four-legged friends
One organization has a furry solution for those who are struggling with their mental health
Return of ‘No Kings’: Here’s what to know about third Seattle protest
Seattle organizers hope to mobilize more than 100,000 people this time around, which would make it perhaps the largest protest in the city's history.
As women’s sports grow, Kansas City-based group empowers women to take leadership roles
Women Leaders in Sports is a professional-development organization based in Kansas City that helps empower and connect women in or seeking leadership across the sports landscape.
Health Alert: Organic beef and pork sold nationwide could be safety, health risk
The products could contain undeclared allergens, harmful bacteria, or other contaminants that put consumer health and safety at risk.
Five Tactics to Modernize Healthcare Data and Analytics
Cleveland Clinic’s Chief Analytics Officer shares insights on the tactics that shaped the organization’s transition to data modernization.
Encouraging progress in inclusive health policies for refugees and migrants
The World Health Organization (WHO) reports a major shift in how countries are responding to the health needs of refugees and migrants, with new data showing more than 60 countries—two thirds of those surveyed—now include them in their national health policies and laws.
Microsoft makes sweeping overhaul of HR organization, internal memo shows
Microsoft's Chief Diversity Officer Lindsay-Rae McIntyre is leaving the company on March 31.
JPMorgan’s Jamie Dimon says remote work breeds ‘rope-a-dope politics’ and stunts young workers’ growth
Dimon has a message for remote workers: the customer comes first.
AHA launches custom innovation summits, revamped reducing disparities in health outcomes webpage
The AHA is now offering custom innovation summits — proven, high-impact workshops designed to convene health care leaders and co-design solutions for organizations committed to reducing health disparities.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Biden admin’s top civil rights lawyer joins NAACP as Trump attacks on voting rights escalate
The former assistant attorney general for civil rights under President Joe Biden, Kristen Clarke, is joining the National Association for the Advancement of Color People (NAACP) as general counsel, according to the organization.
About 40 'No Kings' protests planned across Tennessee. See when and where
In total, organizers estimate about 3,000 events nationwide, surpassing previous 'No Kings' mobilizations since the movement gained traction on President Trump’s birthday in June 2025.
STUDENT ORG SPOTLIGHT
Colorado Law is home to nearly 50 active student organizations. These organizations empower law students to increase their knowledge, gain leadership
UM Health-Sparrow honored for organ, tissue donation impact
University of Michigan Health-Sparrow will receive an award Wednesday for its efforts in giving patients a second chance at life through organ and tissue donation.
Grace Lutheran in Oak Ridge offers a night of entertainment and coffee
Grace Lutheran Church of Oak Ridge presents Coffeehouse on March 27. It's a night to featuring music from three groups, coffee and snacks.
Bioresorbable microneedles track organ health
Nature Reviews Bioengineering - An article in Nature Biomedical Engineering reports a bioresorbable flexible microneedle sensor array for continuous monitoring of organ function for at least 7...
Gulf State Park brush fire causes closure of Fort Morgan East at Highway 59
BALDWIN COUNTY, Ala. -- A brush fire at the Gulf State Park has caused closures in the area.
Students compete at Central Nebraska science fair in Kearney
Organizers said the regional competition featured 40 projects from schools across central Nebraska.
Organized Money: The Business of Betting on Murder with Sen. Chris Murphy
Bet you can’t guess who is insider trading the Iran War.
The Economist launches new Economist Enterprise business unit
The move combines business-to-business teams and units that currently service more than 2,700 organizations globally.
Kaus Earns College Sports Communicators Academic All-District Honors
ITHACA, N.Y. – Cornell women's basketball junior Rachel Kaus has been named to the College Sports Communicators (CSC) Academic All-District team, the organization announced on Tuesday.
Gender equality in science: a distant goal; invisible barriers persist
While the number of women in scientific organisations is increasing, the path towards true equality is slowed down by structural barriers and informal processes
Tacoma Arts Live, longtime WA arts institution, files for receivership
Tacoma Arts Live, a longtime performing arts organization, has filed for receivership. The court process is similar to bankruptcy. Here's what we know.
What's for Lunch? 25 Years of Inspired Science in Schools
The Sisters in Science student organization has quietly shaped young learners in Kalamazoo by presenting hands-on experiences in schools.
These Creatures Have One Cell and No Brain. Scientists Just Discovered They Can Learn.
In 1897 Russian physiologist Ivan Pavlov proved that animals can be trained using associative learning. A new study finds that even single-celled organisms can behave like “Pavlov's dog.”
Brown Named College Sports Communicators Academic All-District
Guard Malea Brown of the Longwood women's basketball team has been named to the 2025-26 Academic All-District® NCAA Division I women's basketball team as selected by the College Sports Communicators, the organization announced Tuesday.
4 Pitt people were named Pittsburgh Business Times 2026 Women of Influence
The awards recognize the region’s businesswomen, including one Pitt dean and three alumnae, who make impactful change by leading organizations.
CelebrateOne secures $3.39M grant to fund for maternal health in Columbus
CelebrateOne secured a $3.39 million grant to fund 15 organizations expanding maternal health services in Franklin County.
French Business Lobby Doesn’t See Inflation Surging on Iran War
France’s largest business lobby, Medef, doesn’t see inflation surging because of the Iran war, the organization’s chief said on Tuesday.
WHO recommends new diagnostic tools to help end TB
On World TB Day, the World Health Organization (WHO) is urging countries to accelerate action to end tuberculosis (TB) and expand access to lifesaving services by using new innovations such as diagnostic tests that can be used near the point-of-care and tongue swabs that can help detect the disease faster reaching more people.
Nominate a Capital Region health care executive who’s making a difference
Who’s running the organizations shaping health care in the Capital Region — and doing it well? That’s the question at the heart of the Outstanding Health Care Executive category in Business Report‘s inaugural Excellence in Health Care Awards. This recognition is for the senior leaders who are making the hard calls, building strong teams and […]
Meet CT’s 2026 Women in Business honorees
Hartford Business Journal’s 2026 Women in Business awards recognize top leaders who are making a significant difference within their organization and the broader community.
Funding for populist-right ‘media-political complex’ exceeded £170m in five years, research finds
Handful of billionaires gave huge sums in particular to media organisations that boosted rightwing politicians, says Liam Byrne MP
Spring Health Fair delivers commitment to student wellness
The Student Wellness Advisory Committee hosted their annual Spring Health Fair on Friday afternoon where students were able to gain free tote bags, learn from live simulations and gain insight on new clubs and organizations centered on wellness.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Black Family Wellness Expo returns to Wichita, promotes health awareness for second year
Organizers say more than 40 different vendors participated in the expo.
WHO verifies deadly hospital attack in war-torn Sudan
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Super PAC spending passes $200M, with some groups hiding their cause
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Downtown Chico business owner voices concerns over street closures for events
A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
Laid off from Morgan Stanley, struggling to find work, pay bills
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San Francisco businesses ready as Bay Bridge lights set to return Friday night
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Providence looks to sell off its health insurance plan
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True Bill Talk: Prosecution & Politics
The March 14 episode of True Bill Talk shifts the podcast’s focus from its typically local level to a national one. Nelson Bunn is the Executive Director of the National District Attorneys Association (NDAA), an organization that influences the policies of thousands of prosecutors across the country. In a conversation with host Alissa Marque Heydari, […]
Keypoint Intelligence Launches Keypoint Engage, Delivering AI-Powered Business Execution as a Service
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NBAA: Business Aviation’s Leadership in Sustainability Innovation Underscored in ‘CLIMBING. FAST.’ Capitol Hill Fly-In
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German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Cycle Nova: Villanova students unite to honor a legacy and advance heart health
Villanova, Pa., March 17, 2026 — Beat for Good, Villanova University’s student‑run organization dedicated to supporting individuals and families affected by cardiovascular disease, hosted its inaugural cycling fundraiser, Cycle Nova, on Saturday, March...
A public health professor is bringing the National Bioethics Bowl to Pitt
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Sangamon County voters approve new tax increase for mental health board
Murphy explained that the mental health board would act as a centralized organization that helps coordinate groups and providers in the Sangamon County area.
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
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US politicians attend event to celebrate links to Northern Ireland
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Forum on harnessing Artificial Intelligence for health equity
Register to this forumOver the past decade, artificial intelligence (AI) has significantly evolved in complexity, performance, and utility. Its integration across a wide range of industrial sectors has accelerated, with healthcare emerging as one of the most transformative sectors. In this sector, AI has enabled high-impact applications – from enhancing the speed and accuracy of disease diagnosis and supporting clinical decision-making, to strengthening public health initiatives such as disease surveillance and workforce optimization. Moreover, AI holds immense potential to empower individuals, enabling them to take greater control of their personal health and well-being. Yet the central question remains: Who benefits, who is at risk, and do these innovations close or widen health inequities? While the potential of AI-enabled applications is substantial, many countries have approached their adoption with caution. This hesitancy stems from concerns about risks and benefits, including model bias, data breaches, privacy violations, and the erosion of professional skills due to over-reliance on AI. Additional barriers include inadequate data infrastructure and a lack of robust evidence on the most effective forms and interfaces of AI to enhance service delivery and system performance. Moreover, the rapid rise of Generative AI has introduced a heightened urgency for the development of comprehensive governance and ethical frameworks. The Asian Development Bank (ADB) Health Practice Team and Digital Sector, in collaboration with the World Health Organization (WHO) Regional Office for the Western Pacific, are convening the Forum on Harnessing AI for Health Equity on 25–26 March at ADB Headquarters. Senior health officials from 16 developing member countries (DMCs), alongside leading researchers, innovators, and policymakers from across Asia and the Pacific, will engage in discussions on how AI can be governed, financed, and scaled to deliver healthier lives for all. The forum is funded through the High-Level Technology Fund with support from the Government of Japan. Objectives The two-day forum aims to:Identify high-impact, evidence-based health AI use cases suitable for resource-constrained settings and map out a pipeline for potential supportIntroduce and validate the WHO's policy guidance on minimum necessary ecosystem for countries and institutions to self-assess readiness for AI adoptionObtain initial commitment from participating stakeholders to join a pilot regional initiative focused on data/model sharing for a priority health challengeEndorse a prioritized set of actionable policy recommendations focusing on governance, regulation, and sustainable financing necessary to scale high-impact health AI use cases in resource-constrained settings Target participants The forum will convene participants from 16 ADB DMCs including Bangladesh, Bhutan, Cambodia, Cook Islands, Fiji, Indonesia, Lao People's Democratic Republic, Mongolia, Nepal, Palau, Papua New Guinea, Philippines, Sri Lanka, Thailand, Uzbekistan, and Viet Nam. In addition, health system leaders and practitioners, private sector technologists, academic experts, representatives from civil society organizations, development partners, and philanthropic institutions engaged in AI for Health from Australia, the People’s Republic of China, Japan, Malaysia, New Zealand, Singapore, and the Republic of Korea will also be invited. SessionsDay 1 (25 March)Session 1: AI Use Cases for the Care Continuum: Improving Access and QualitySession 2: Adopting a risk-based approach for AI use case prioritizationSession 3: Establishing the Minimum Ecosystem for Implementation Risk ManagementSession 4: Future-Ready Health Workforce: Building Competency for Human-AI CollaborationDay 2 (26 March)Session 5: The Political Economy of AI in Health: Understanding Stakeholder Interests and their Impact on EquitySession 6: AI and Health Financing: Supporting Fair Coverage and ProtectionSession 7: AI Regulation and Oversight: Pathways for Different RealitiesSession 8: The Way Forward – Building Alliances and Regional Partnership How to registerThe forum will be held in a hybrid format. In-person attendance is by invitation only, while livestreaming of the forum will be available to the public. To register, please complete this form on or before 24 March 2026.Event organizers / partnersAsian Development Bank (ADB)WHO Regional Office for the Western Pacific High-Level Technology Fund (HLTF)ContactAkihito WatabeHealth Specialist, SD3-HSDawatabe@adb.org Jae Kyoun KimHealth Specialist, SD3-HSDjkkim@adb.org
First-ever 517 Business Awards celebrates capital region economic drivers
Organizers emphasized the importance of businesses working together to support each other and recognizing positive work in the community.
Medicaid drug reimbursements could end for health care providers across Indiana
Health centers warn they could lose millions in rebates under the states proposed change, which would end Medicaid drug rebates for health organizations.
APSA Announces Renewed Partnership with Cambridge University Press -
The American Political Science Association (APSA) is pleased to announce that we have renewed our partnership with Cambridge University Press for the publication of the three member-wide APSA journals and six organized section journals: American [...]
This overlooked organ may be more vital for longevity than scientists realized
The role of the thymus in our long-term immunity and health is poorly understood. A new study suggests we need to pay attention
Thymus may be critical to adult health
Research indicates the often-overlooked organ can be key predictor in longevity, disease risk, and cancer treatment outcomes.
Misalignment and Risk Tolerance Gaps Undermine Business Resilience, Kroll Study Finds
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Science is finally confirming the most mysterious symptoms of endometriosis
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Rochester business leaders push for increased charter school funding
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Argentina officially withdraws from World Health Organization, following US
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Ruling on RFK Jr.’s Vaccine Policy Changes Leaves Health Groups Scrambling
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Paradigm Launches Surface, an AI-Native Platform That Connects Culture to Business Performance
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Washington Spirit Named Finalist for Sports Business Journal’s 2026 Sports Team of the Year
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Washington Spirit Named Finalist for Sports Business Journal’s 2026 Sports Team of the Year
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DETROIT PISTONS PARTNERING WITH SCRIPPS SPORTS, TV-20 DETROIT TO BROADCAST FIVE GAMES OVER REMAINDER OF SEASON
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Alibaba Just Announced a Business Reorganization. Can It Get the Stock Back on Track?
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Psychiatrists’ Use of Biomarkers Could Open a New Window Into Mental Health Diagnoses
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Gossip: UCL key in Rogers decision
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Pair accused of operating fake contracting businesses in Lower Merion Township
Police in Lower Merion Township are looking to identify further victims of an organized fraud scheme involving fake contracting businesses.
University of Florida Penalizes GOP Group Over Antisemitism Accusations
After the University of Florida restricted the Republican organization from operating on campus, the group sued the university arguing its First Amendment rights were violated.
JPMorgan Hires Goldman’s Zhang to Co-Head China IB Business
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Federal judge blocks RFK Jr.'s changes to childhood vaccine schedule
The ruling stems from a lawsuit brought by major medical organizations including the American Academy of Pediatrics.
Judge Strikes Down Kennedy’s Vaccine Policies
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Morgan Wallen to launch new 24/7 SiriusXM channel, play Nashville show
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Kering adapts the presentation of its businesses, to align with its strategic model and organization
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Disabled CDC staff still missing accommodations
The transformation of organ transplantation, an age to start considering statins, and other health news
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Strengthening One Health Field Epidemiology Capacity in the WHO South-East Asia Region
Recent public health emergencies—including the COVID-19 pandemic, recurrent zoonotic disease outbreaks, and the high level of antimicrobial resistance—have underscored the urgent need for strong, multisectoral field epidemiology capacities. This reinforces the importance of a workforce equipped with One Health field epidemiology competencies. To address this need, WHO works with the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), and the World Organisation for Animal Health (WOAH), as part of Quadripartite Alliance for One Health, to strengthen field epidemiology training programmes using a One Health approach.These efforts are aligned with WHO SEARO’s Strategic Framework for Action for Strengthening Surveillance, Risk Assessment and Field Epidemiology and the Regional Roadmap to Advance Field Epidemiology Capacities 2025–2029 emphasize workforce development, multisectoral collaboration, and enhanced preparedness for health emergencies. With funding from the Pandemic Fund, The Competency for One Health Field Epidemiology (COHFE) integration within Field Epidemiology Training Programmes (FETPs) or similar initiatives has been initiated in Bangladesh and India and is planned in Sri Lanka.BangladeshIn Bangladesh, COHFE is being adapted to strengthen the Field Epidemiology Training Programme, Bangladesh (FETP-B) Advanced programme. Initiated in July 2025 and led by the Institute of Epidemiology, Disease Control and Research (IEDCR), the process brought together stakeholders from human, animal, and environmental health sectors, academia, and laboratories.A Multisectoral Working Group (MWG) was established to guide implementation, conduct readiness assessments, and identify opportunities to institutionalize One Health collaboration. Through national multisectoral consultations and a competency prioritization workshop held in Dhaka in November 2025, stakeholders identified priority technical competencies for surveillance, outbreak investigation, data analysis, and risk assessment, alongside functional competencies related to leadership, coordination, and the laboratory–epidemiology interface. The process also surfaced systemic barriers—such as challenges in data sharing and limited joint investigations—enabling targeted recommendations. These outcomes are guiding curriculum revision, the introduction of One Health simulations and joint field exercises, and the development of a national multisectoral mentorship pool, with updated training materials expected to be implemented in the upcoming cohort.Figure 1. Competency prioritization involving multisectoral stakeholders“COHFE represents a significant step forward in operationalizing the One Health approach. The collaboration between national institutions and the Quadripartite partners is critical for building resilient systems to address complex health challenges in the region.”, Prof. (Dr) Tahmina Sirin, Director, Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh.Aligning India’s One Health Training with COHFEIn India, the National Centre for Disease Control (NCDC) has strengthened One Health workforce development through its SectorConnect initiative. WHO supported a comprehensive competency mapping and curriculum review to align the Field Epidemiology Programme in One Health (FEP-OH) with all 14 COHFE domains. The review identified strong foundations while generating actionable recommendations to strengthen One Health learning outcomes, expand joint field-based learning, and enhance competency-based assessment. These improvements are informing programme refinement and phased scale-up across additional states.Figure 2. Strengthening learning outcomes for the SectorConnect FEP OH CurriculumThrough these efforts, WHO SEARO will continue to support countries to move from separate sector-based training toward an integrated, impact-driven One Health field epidemiology workforce capable of addressing complex health threats at human-animal-environment interface.ReferencesFood and Agriculture Organization of the United Nations, World Health Organization, & World Organisation for Animal Health. (2024). Competencies for One Health field epidemiology (COHFE) framework. https://www.who.int/publications/i/item/9789240080058World Health Organization. (2023). Strategic framework for action for strengthening surveillance, risk assessment and field epidemiology for health security threats in the WHO South-East Asia Region. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290210030World Health Organization. (2024). Regional roadmap to advance field epidemiology capacities in the WHO South-East Asia Region 2025–2029. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290229544