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Elite Eight: Purdue vs Arizona, Offensive Heavyweights Meet
Purdue and Arizona are set for a heavyweight offensive fight tomorrow night.
Stocks tumble, Dow confirms correction territory, as Middle East tensions drag
U.S. stocks tumbled on Friday, with each of the three major indexes closing at their lowest levels in over seven months and the Dow confirming it was in correction territory
SAVE plan: Millions of student-loan borrowers resume payments in fall
After eliminating the SAVE student-loan repayment plan, Trump's Education Department is now advising borrowers to select a new plan and start paying.
Business Lookahead: Gauging the war's impact
STORY: From a worrying drop in stocks to a surge in energy prices from the war in the Middle East to key data on jobs and trade, these are the stories to watch in business and finance in the coming week. ::Look Ahead::War impactThe first quarter is ending with financial markets at the mercy of geopolitics.The Iran war has wiped roughly $7 trillion off global stocks since it erupted.With oil prices up nearly 70% year to date, suddenly interest rates are heading up, rather than down, and energy-hungry AI does not look like such a slam-dunk anymore.Meanwhile, gold has plunged 16% after being nearly unstoppable since the start of 2025.We’ll see whether markets roll on or rollover as the second quarter begins.::Job growth in focusThe U.S. jobs report for March comes out Friday.It will offer a crucial view into the economy's health as investors gauge fallout from the energy price surge.Monthly payrolls are seen rising by 48,000, according to a Reuters poll. February's surprisingly weak report caught Wall Street off guard, showing nonfarm payrolls fell by 92,000 while the unemployment rate increased to 4.4%.Uncertainty over the Iran war is also clouding the economic forecasts for the Federal Reserve, with Wall Street pulling back on expectations for U.S. interest rate cuts this year as the oil price surge fuels concerns about rising inflation.Other U.S. data in the coming week includes retail sales for February and reports on manufacturing and services activity.::Chip checkSouth Korea releases its trade data for March on Wednesday.It will provide an early indicator of how the global economy is holding up in the face of the war and the resulting shock to energy prices. Korea's export-heavy economy is a bellwether for global trade and one of the first to report data from the previous month.Its manufacturing fortunes are of even greater interest than usual, not just because of its dependence on Middle Eastern energy imports, but also because its world-leading DRAM chips are of critical importance to the AI sector and currently in short supply too. ::Inflation assessmentAnd flash euro zone inflation for March is due on Tuesday. After long hovering around the 2% mark, higher energy prices are now expected to push headline inflation up, as they did in 2022. The question is, how large and sustained any jump in inflation might be.Early data is not painting a pretty picture. Private sector growth in the euro zone slowed sharply in March, with input costs rising to their highest in more than three years and supply chains being significantly disrupted.Money markets are now heavily pricing in a rate hike which was almost unthinkable before the Iran war.
Planned Parenthood, groups launch campaign against transgender ballot measures in Colorado
Planned Parenthood and other groups have launched a coalition to oppose two ballot measures that would ban transgender surgeries among children and require student athletes to only join sports teams that correspond to their biological sex. The two measures will appear in this year’s November ballot, setting the stage for a statewide debate over sports, […]
Poppy Playtime Chapter 6 Plans, Film Adaptation: Mob Entertainment
Survival horror game "Poppy Playtime" launched its fifth installment Feb. 18, breaking records set by the video game franchise's previous debuts.
New movies to watch this weekend: See 'They Will Kill You' in theaters, rent 'Send Help,' stream 'Pretty Lethal' on Prime Video
Check out "Mike & Nick & Nick & Alice" on Hulu — or sink your teeth into some horror.
Live: UFC Seattle early weigh ins results
Ultimate Fighting Championship (UFC) is just over 24 hours away from the upcoming UFC Seattle mixed martial arts (MMA) event, booked for tomorrow night (Sat., March 28, 2026) on Paramount+ from inside Climate Pledge Arena in Seattle, Washington. UFC Seattle will be headlined by the middleweight main event between former champion Israel Adesanya and 185-pound […]
Your eyes do not deceive you: Lauren Conrad and Kristin Cavallari are BFFs on the 'Laguna Beach' reunion red carpet
Lauren Conrad and Kristin Cavallari posed together on the 'Laguna Beach' reunion red carpet after squashing their feud: 'As you get older, you're not worried about the small stuff'
Stock market today: Nasdaq 100 enters official correction amid Iran sell-off
The Nasdaq 100 entered correction territory on Friday. AI jitters, the Iran war, and a memory stock sell-off have dragged the index lower.
Resident Evil Lore Master Reflects on What Requiem Got Right and Wrong as the Franchise Returned to Raccoon City and 'Retconned' Its Destruction
Resident Evil's unofficial lore master has weighed in with his thoughts on Resident Evil Requiem, which adds a sizable new chapter filled with story revelations to Capcom's veteran horror franchise.
Opinion: A billionaire walks into a Golden Corral: The Rick Jackson story
Voters at Jackson's stump speech connected with the wealthy health care executive. Some said they were reminded of Trump.
How many teams are in the UFL? New teams, coaches, more to know for 2026
The Columbus Aviators, Louisville Kings and Orlando Storm have joined the UFL for the 2026 season. Here's more to know about the spring league's teams.
From pause to progress — a better path on AI policy
By Brittany Morris Saunders and Loren Furman Last year, following the Special Legislative Session, we wrote in Colorado Politics that delaying Colorado’s AI Act was not a setback. It was an opportunity. We asked state leaders to pause, bring more voices to the table and take the time to get this right. That is exactly […]
Long Covid vs UConn’s GA health insurance
UConn’s proposed increases to the health insurance premiums would contribute to health disparities, and make healthcare even less accessible than it is now.
A surprise resignation could open the door for an independent to win a Montana Senate seat
Two-term GOP Sen. Steve Daines shocked Montana when he announced his retirement. Democrats worry a new independent candidate will split their party's vote.
Judge rejects Green Party candidate’s bid to appear on California governor ballots
California Green Party candidate Butch Ware failed to submit correct tax returns in time to appear on the June ballot for governor, a judge ruled Thursday.
Correction: Self-powered mechanoluminescent elastomer for solar-blind ultraviolet emission
Light: Science & Applications - Correction: Self-powered mechanoluminescent elastomer for solar-blind ultraviolet emission
Can pesticide exposure before pregnancy affect babies’ health?
A new study suggests a correlation between certain chemical compounds and lower newborn health scores.
ECU Health patients with UnitedHealthcare worried amid contract negotiations
Multiple ECU Health patients with UnitedHealthcare said they’re receiving messages indicating the two sides are in negotiations, and ECU Health may become out of network for United patients.
LGBT People Experience Widespread Concerns and Challenges When it Comes to Health Care Affordability
This analysis highlights the health care affordability challenges facing LGBT adults, a growing population that faces health related disparities. Findings from KFF Health Tracking Polls show that LGBT adults face more widespread concerns with affording basic necessities, including health care, compared to non-LGBT adults.
Alien Deathstorm: Sci-fi Survival and Action Combine for a New First-Person Horror Hybrid
New from Rebellion (Atomfall, Sniper Elite) is Alien Deathstorm, an atmospheric first-person horror hybrid, coming to Xbox and Xbox Game Pass.
Private Equity firm says
Thoma Bravo's Holden Spaht said the popular narrative around AI and software is incorrect, and not all software makers are equally exposed to disruption.
Movie Review: 'Two Prosecutors' is a perfect nightmare of state corruption
Sergei Loznitsa’s “Two Prosecutors” is a nightmare of government corruption so perfectly composed that, by the time it reaches its chilling conclusion, you feel nearly as entrapped as its young
UCSB professors honored by the American Association for the Advancement of Science
Professors Shelly Gable, David Morrison, Javier Read de Alaniz and Kelly Caylor have joined the esteemed ranks of the American Association for the Advancement of Science (AAAS).
The Best Time to Eat High-Fiber Foods If You Want to Poop Tomorrow, According to Dietitians
Learn the best time to eat fiber to help you poop the next day, plus which foods work fastest and how long fiber takes to improve digestion.
Good Morning, Nashville! Talking Immigration Data Politics at Vanderbilt University
After a busy day on Capitol Hill yesterday, I landed in Nashville, Tennessee, last night for an exciting two days on campus at Vanderbilt University. Carwil Bjork-James, an anthropologist whose creative use of database construction to support critical scholarship resonates strongly with my own work, generously invited me to give a talk today about the politics of immigration data and to join a Wikipedia edit-a-thon tomorrow on the topic of immigrant detention. I encourage you to check out Carwil’s database project “Ultimate Consequences” about political deaths in Bolivia after 1982, and his book The Sovereign Street: Making Revolution in Urban Bolivia. My talk today is titled “Untangling the Messy Politics of Immigrant Detention Data.” I’ll focus on how immigrant detention data (not just detention centers themselves) become sites of controversy—from the collection and classification choices that shape what we can know, to the strategic withholding and distortion of data for political ends. Drawing on research spanning multiple administrations, I’ll trace how current data controversies in the second Trump administration connect to long-standing tensions in how we measure, interpret, and communicate about immigration. My goal is to move beyond simple partisan narratives and offer a practical guide for anyone working with immigration data to explore both the pitfalls to avoid and the creative opportunities for more transparent, rigorous public communication about immigration realities. If you are on campus, please stop by. Tomorrow I will join Carwil and Vanderbilt students for a Wikipedia Edit-a-Thon to edit and update Wikipedia entries related to immigrant detention with the latest robust information and data. This event is designed to orient participants into how to edit on Wikipedia, provide them with data-driven starter templates on detention facilities, and allow each person to produce an initial article on one element of the network of ICE facilities or one death in custody this year. The workshop is also a demonstration of how to use open data sources to build public knowledge—something I am deeply passionate about. Thank you to Vanderbilt University, the Spatial Histories series, and Carwil for hosting me. I would love to be a part of conversations and workshops related to immigration data on your campus. Students are really eager these days to have informed, critical, and data-driven explorations of our current immigration system. Reach out anytime if you want to discuss the possibility of bringing me to your campus. Subscribe
Callodine Specialty Income Fund Adds Entertainment Lending and Aviation Finance Strategies
Callodine Group (“Callodine” or the “Company”) is pleased to announce the addition of Corrum Capital Management (“Corrum Capital”) as a sub-advisor to the Ca...
Ron Conway is worried that California's proposed wealth tax could pass
"Our job is to get Gavin to negotiate this so that it doesn't get to the ballot," Tech investor Ron Conway said.
Bayview Buzz: Harvard Business School comes to 3rd St.
A Harvard Business School alumni group finds a new vision for the Third Street corridor. Plus, Cafe Melange reopens under new ownership.
Q&A: An AI-Powered Way to Help Detect Brain Bleeds Faster
Timing and accuracy are vitally important when it comes to a brain bleed. Viz.ai, the company behind an artificial intelligence platform for disease detection and workflow optimization used in about 2,000 U.S. hospitals, wanted to streamline the process of identifying hemorrhages. Their solution,
Doctors worry about FDA scrutiny of RSV shots to protect babies
The antibody shots are about 80% effective at preventing babies from ending up in intensive care because of RSV. The drugmakers behind them maintain they're safe.
Concern over Health Care Affordability Is Widespread
A majority of Californians are pessimistic about their future health care costs. These worries are fueling broad opposition to federal health care rollbacks.
Corus Entertainment Secures Court Approval For $363 Million Debt Plan
A fall in linear TV advertising and hefty borrowings led the major Canadian buyer of U.S. series like 'Survivor' and 'NCIS' to launch a recapitalization transaction to cut annual interest charges via a new parent, NewCo.
MLB games tomorrow: Opening Day schedule, times, how to watch for March 26
Here's the full MLB schedule, for March 26, including game times, TV channels, scores and how to stream.
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Pharma bribery corrupts health care, puts patients at risk, new review warns
Sham clinical studies, slush funds and shell companies: A new review shows how pharma firms allegedly bribed their way to drug approvals and sales.
Effectiveness of politicians’ public denials amid corruption accusations examined in new study
A new article investigates how public denials by politicians accused of corruption influence electoral accountability and why positive and negative partisanship shapes voter reactions.
How I Learned to Stop Worrying and Love the New York Yankees
A feel-good story about winning, losing, raising kids, the joy of sports, and, well, the Battle of Stalingrad.
How private credit could quickly become a public problem
Investors are increasingly yanking their money from private credit funds that lend directly to businesses on worries that could unfortunately become all of our worries, whether we’re trading stocks or just going about our own lives.
Volunteers honor local sports leader Jim Morris during March Madness preparations
Hundreds of volunteers spread out across Indianapolis Tuesday to help prepare the city for next week's NCAA Men's Final Four basketball games.
Rowing Science: Hit the Bench Pulls and Dead Lifts, Skip the Squats
A study of German national team rowers found a high correlation between 2000m speed on the erg and o
Man in custody after report of assault with deadly weapon at Venice health center
Law enforcement officers responded Tuesday to a report of an assault with a deadly weapon outside a health center in Venice Officers, including SWAT team members in at least one armored vehicle, were at the Chuck Lorre Rose Avenue Wellness Center after the report of a suspect with gun. A standoff ensued before the man walked along the outside of…
Marvel Rivals Devs Won't Introduce Original Characters Anytime Soon, Because There Are Simply Too Many Marvel Characters Already
NetEase Games isn't worried about balance in Marvel Rivals as its roster expands with more playable heroes, but don't expect to see any original characters anytime soon.
Residents, business owners express mixed reaction about roadway project underway in Trussville
A major roadway project along Highway 11 is entering its final phase in Trussville, with city leaders acknowledging temporary inconveniences while emphasizing long-term traffic relief in one of the area’s fastest-growing corridors.
ICE detains longtime Kearney business owner and entrepreneur
Immigration and Customs Enforcement detained a Kearney business owner on March 11. Carlos Godinez, the owner of Nick’s Gyros for the past 15 years, is currently at the Hall County Department of Corrections on an ICE hold.
Democrats’ long-shot bid to flip Alaska’s Senate seat
Democrats are hoping for an upset in Alaska’s Senate race. U.S. Rep. Mary Peltola, a Democrat, is trying to unseat Republican incumbent Sen. Dan Sullivan. We discuss the major issues at play, plus why Republicans are backing an effort to repeal Alaska’s ranked-choice voting system.This episode: voting correspondent Miles Parks, senior political editor and correspondent Domenico Montanaro, and Alaska Public Media Washington correspondent Liz Ruskin.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
Trump casts Florida ballot by mail as he pushes Congress to severely limit that voting option
Trump has in the last week called mail-in voting "cheating" and "corrupt as hell" as he urges Congress to pass the SAVE Act, a sweeping bill that would bar universal mail ballots.
Commentary: Morristown youth sports need more coaches—here’s how to help
A student aims to match experienced athletes with youth leagues in need of coaches.
Why going to an HBCU might be better for Black students’ health
A study found correlation between the environment and long-term wellness in sample of 1,978 who attended college between 1940-80
John Fogerty, Cyndi Lauper, more join forces to say 'Thank You, NYPD'
The 'Thank You, NYPD' concert will feature John Fogerty, Cyndi Lauper and Fat Joe, comedians Chris Distefano and Sam Morril, and more.
Special Battleground Report on Food and Health Part II: Messages
This Navigator Research report covers messaging guidance to effectively communicate on food and health-related issues to Americans in the battleground.
Old Wisdom, New Science, and the Tools of Tomorrow
How can firefighters navigate between the hard-earned practical wisdom of the past and modern technological developments? Scott Guillerault says fire research may point the way.
2026 ‘Dirty Dozen’ produce: Nearly 100% tested positive for pesticides, including ‘forever chemicals’
The 2026 “Dirty Dozen” list of most contaminated produce has a worrisome finding. Many of the most common pesticides are also potentially toxic “forever chemicals.”
Can pesticide exposure before pregnancy affect babies’ health?
A study co-authored by UCLA researchers suggests certain chemical compounds correlated with lower newborn health scores.
Cargo Headed to Station, Week Begins with Science Prep and Maintenance
A cargo spacecraft is in orbit catching up to the International Space Station for a docking tomorrow to deliver food and supplies to the Expedition 74 crew. Aboard the orbital lab, the seven residents kicked off the week with science operations prep, routine maintenance, and getting systems ready for a future spacewalk.
Feature: Where The Heck Do You Start If You've Never Played Resident Evil?
Enter the world of survival horror
Rahm Emanuel proposes banning all federal employees from betting on prediction markets
Rahm Emanuel is proposing a far-reaching measure to crack down on betting in predictive markets in Washington as part of an effort to call attention to what he sees as a culture of corruption gripping the nation’s politics
When Voters Worry About ‘Affordability,’ Many Point to Health Care
Democrats have had limited political success running on the Affordable Care Act, even with its relative popularity. Now President Trump’s health care cuts may have given the issue new resonance.
As mayoral election looms, D.C.’s business class worries about what’s next
A potential leftward shift in the wake of the pandemic and the Trump administration’s cutting of thousands of federal jobs has sparked unease in the city’s business community.
City of Paducah Finance Department to host informational workshop on Business License Renewals
In case you missed it, the City of Paducah Finance Department will host an informational workshop on Business License Renewals for local business owners at the McCracken County Library tomorrow,
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Immigration crackdown impact on local Latino-owned businesses
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Chuck Norris, martial arts master and actor, dies at 86
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Action legend and "Walker, Texas Ranger" star Chuck Norris has died, his family confirmed in a statement.
Chuck Norris, martial arts master and actor, dies at 86
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A Grip on Sports: The Zags survive a first-round rock fight in Portland, one that also caused contusions for those watching from home
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‘Dune’ tried to warn us against AI
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German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
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