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Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth

Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine

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Oct 5 • 6:44 AM EDT • Science • goldrushcam.com
New AI Detector Spots Machine-Written Science Papers With 91.5% Accuracy

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Oct 5 • 6:41 AM EDT • Science • bioengineer.org
BridgeBio taps Hip Hop Public Health and others up to put a new beat on ATTR-CM awareness

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Oct 5 • 6:00 AM EDT • Health • fiercepharma.com
German and US scientists win Nobel Prize in medicine for research on brain activity

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Oct 5 • 5:37 AM EDT • Science • dw.com
Rethinking discovery: how powerful screening tools are redefining the search for new medicines

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Oct 5 • 5:23 AM EDT • Science • ipsen.com
Digbi Health Study of Nearly 16,000 Members Finds Precision Biology GI Care Delivers IBS Relief at Scale

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Oct 5 • 4:32 AM EDT • Health • finance.yahoo.com
Africa’s Ghost Plants: Why Scientists Are Digitizing Centuries of Botanical History

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Oct 5 • 4:00 AM EDT • Science • atmos.earth
The genetic secret helping bats survive a deadly epidemic

We’re easing you into Halloween season with an episode about bats. There’s a silent serial killer decimating little brown bats as they hibernate. White nose syndrome has driven populations across the U.S. to almost the brink of extinction over the last decade. But recently, conservation biologist Giorgia Auteri and her team noticed several genetic mutations in the survivors. These mutations could explain how natural selection has shifted the existing population – and inform conservation efforts in the future.Interested in more animal science? Email us your question at shortwave@npr.org.Support public media with NPR+ and enjoy perks for over 25 podcasts like this one. This show’s perks include sponsor-free listening. Learn more at plus.npr.org.

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Oct 5 • 3:00 AM EDT • Science • npr.org
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‘They misunderstand science’: Research attempting to tie autism to changes in the gut microbiome comes under fire

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Oct 5 • 12:01 AM EDT • Science • geneticliteracyproject.org
MedX Health Appoints Monaderm as a Representative for SkinSecure™ Across Europe for Beauty and Aesthetics Research

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Oct 5 • 12:00 AM EDT • Health • finance.yahoo.com
Bora Biologics and Protect Animal Health Enter Strategic, Long-Term Multi-Project Collaboration to Advance Antibody-Based Animal Health Products

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Oct 4 • 8:02 PM EDT • Health • rutlandherald.com
Bora Biologics and Protect Animal Health Enter Strategic, Long-Term Multi-Project Collaboration to Advance Antibody-Based Animal Health Products

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Oct 4 • 8:00 PM EDT • Health • finance.yahoo.com
Bora Biologics and Protect Animal Health Enter Strategic, Long-Term Multi-Project Collaboration to Advance Antibody-Based Animal Health Products

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Oct 4 • 8:00 PM EDT • Health • newswire.com
Scientists discover 57 new marine species lurking in the depths of the South Atlantic

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Oct 4 • 4:11 PM EDT • Science • foxweather.com
Booked, busy and really pregnant: 'Verity' star Anne Hathaway's nonstop year of blockbusters

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Oct 4 • 1:09 PM EDT • Entertainment • yahoo.com
AI’s Real Gift to Science

Advanced models can help researchers sort through mountains of biological data.

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Oct 4 • 11:56 AM EDT • Science • theatlantic.com
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Oct 4 • 11:55 AM EDT • Health • oncodaily.com
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Oct 4 • 6:00 AM EDT • Science • bostonglobe.com
Not All Magnesium Supplements Are Equal: What Science Says About Absorption

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Oct 4 • 1:06 AM EDT • Science • bioengineer.org
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Oct 3 • 3:01 PM EDT • Science • futurism.com
New Journal Section Puts Epigenetics on Trial: Ethics, Society and Science Collide

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Oct 3 • 2:17 PM EDT • Science • bioengineer.org
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Oct 3 • 10:34 AM EDT • Health • newson6.com
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Oct 3 • 9:57 AM EDT • Science • oncodaily.com
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Oct 3 • 8:00 AM EDT • Science • sciencedaily.com
Iceland to broach defense cooperation as Rubio visits next week

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Oct 2 • 10:54 PM EDT • Entertainment • thederrick.com
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Oct 2 • 5:55 PM EDT • Sports • sports.yahoo.com
Ex-US congressman David Rivera sentenced to 10 years in prison for Venezuela lobbying

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Oct 2 • 5:05 PM EDT • Politics • bbc.com
Dems demanding Venezuela brief face State Dept fury as senators leave town without answers

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Oct 2 • 3:03 PM EDT • Politics • foxnews.com
Studying Science in an Anti-Scientific Time

This Chronicle Review Deep Cut was first published in 2025. By Julianne Werlin Thanks for reading The Chronicle Review! Subscribe for free to receive new posts and support my work. Subscribe The last two decades have not been kind to science studies. Already bruised and battered by the “science wars” of the 1990s, by the 2000s sociologists of science — who had long argued that science had to be understood in its human context — were encountering the funhouse-mirror version of their own views in right-wing critiques of climate scientists. It was enough to give some prominent scholars pause. “Was I wrong to participate in the invention of this field known as science studies?” asked Bruno Latour, the most famous sociologist of science in the world, in 2003. “Should we apologize for having been wrong all along? Or should we rather bring the sword of criticism to criticism itself and do a bit of soul-searching here: What were we really after when we were so intent on showing the social construction of scientific facts?” In response, Latour proposed a change of method and attitude. Science studies, now chastened and contrite, would no longer seek to strip facts of their authority, but to enrich and enhance them. What this meant in practice was never fully clear. But his diagnosis of problems resonated, even if his solutions did not. Latour’s exercise in public hand-wringing signaled a shift in mood. By 2016, with the first election of Donald Trump, the idea that skepticism of science was a right-wing position, not a left-wing one, had become a commonplace, discussed eagerly in The New York Times. For liberals, vaccine denial during the Covid era and Trump’s second-term attacks on the funding of scientific research, covered extensively in these pages, added a new urgency to the defense of science on both practical and principled grounds. There was little appetite for a sociology or philosophy of science that emphasized the messiness and missteps of the scientific process rather than its integrity and triumphs. The distinguished historian of science Peter Dear’s new book, The World as We Know It: From Natural Philosophy to Modern Science (Princeton University Press, 2025), which seeks to tell the story of 18th- and 19th-century science for a general public, may seem comfortably remote from these bitter contests. In its 16 short chapters, Dear draws swift, sure sketches of major discoveries from Newton to Einstein, ably guiding the reader through debates on stellar nebulae, animal taxonomy, atomic chemistry, evolution, and other flashpoints in the history of science. But though a work of history, Dear’s book must still negotiate our polarized present. In a blurb on its back cover, the historian of biology Lynn K. Nyhart alludes to the “present moment, when scientific knowledge is being swamped by misinformation and its institutions are under siege.” Dear himself, in his conclusion, refers to the “yard signs” and “bumper stickers” that proclaim “Science Is Real.” One antidote to both anti-science propaganda and to reductive slogans in science’s defense is a robust history and philosophy of science: exactly what Dear’s scholarship has long offered. But his new book illustrates how difficult such work has become. Dear, an emeritus professor of history at Cornell University, is best known as a creative and philosophically minded historian of the Scientific Revolution. His edited volume The Literary Structure of Scientific Argument (1991) analyzed the rhetoric of Galileo’s thought experiments to brilliant effect. Discipline and Experience: The Mathematical Way in the Scientific Revolution (1995) was a major contribution to the analysis of scientific experiments in early modern Europe and beyond, while Revolutionizing the Sciences: European Knowledge in Transition, 1500-1700 (2001), now in its third edition, remains one of the best overviews of the profound epistemological upheavals of 16th- and 17th-century science. But Dear has also ventured into later periods. Nearly two decades ago, in The Intelligibility of Nature: How Science Makes Sense of the World (2006), he turned to the 18th and 19th centuries to sketch a history and theory of scientific knowledge. Aimed at a generalist audience, Dear’s simple prose belied serious philosophical ambitions. Science, Dear argued, has two aspects: “natural philosophy,” the quest to understand the true nature of the universe, and “instrumentality,” the applied skills and technologies that allow us to manipulate the world for human advantage. Both strands are ancient, but the innovation of the phenomenon we call “science” was to yoke them together. As Francis Bacon wrote, “Human knowledge and human power meet in one; for where the cause is not known, the effect cannot be produced,” an insight typically abridged to “knowledge is power.” Or, in Bertrand Russell’s characteristically blunt phrase, science has two functions, “1. to enable us to know things, and 2., to enable us to do things.” So far, so conventional. But Dear took issue with this familiar story in one respect. Bacon’s formula implied that theory and practice could be fused in a single method. In fact, Dear argued, the quest to understand nature and the desire to manipulate it were coupled only loosely. They could come together, but they could also pull apart. Focusing on natural philosophy, the “knowing” half of the scientific circle, he used a series of case studies from cosmology, taxonomy, chemistry, electromagnetism, and quantum theory to show how theories changed over time, in dialogue with practice, but never reducible to it. Take the case of matter, the basic substrate of the physical world. In the 18th and 19th centuries, scientists not only disagreed about what it was, but also about how well it could be known. In 1789, the chemist Antoine Lavoisier dismissed speculation about the atomic composition of chemicals as “discussions entirely of a metaphysical nature,” as he sought to orient chemistry away from philosophical abstraction and toward laboratory results. But in the 19th century, atoms returned with a vengeance in the atomic chemistry of John Dalton, who wanted to explain the underlying structure of nature. It was not just that Dalton and Lavoisier had a different set of experimental results, or even a different theory, Dear showed. What counted as an explanation had changed. In arguing that scientific theories depended on their intelligibility to human beings with complex arrays of beliefs and commitments, Dear was in sympathy with science studies. Key figures such as the sociologist Steven Shapin emphasized the importance of psychological mechanisms like trust in the formation and acceptance of scientific ideas. But in focusing on the scientific pursuit of knowledge, not its politics or economics, Dear resisted the more cynical perspective of some of his colleagues. The Intelligibility of Nature strikes a very different note than Shapin’s collection of a few years later, Never Pure: Historical Studies of Science as If It Was Produced by People With Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority (2010), to name just one example. Walking a very fine line, Dear depicted science as driven at once by complex social dynamics and by the intellectual power of real discoveries. It was a testament not only to his own acumen but also to the vitality of the field that he was able to do so. Nearly two decades later, The World as We Know It returns to the questions broached in The Intelligibility of Nature. Like Dear’s earlier study, it begins with the Newtonian cosmos and ends with debates between Einstein and Bohr on quantum physics. Beyond its terminal figures, many of the same characters appear in both studies, including the naturalists John Ray and the Comte de Buffon; the chemists Étienne François Geoffroy, Antoine Lavoisier, and John Dalton; as well as Charles Darwin and Michael Faraday, among others. Its subject is nearly identical: As in The Intelligibility of Nature, The World as We Know It considers natural philosophy as opposed to instrumentality, here defined as the “desire to create a picture of what the world is really like — the world as God knows it — rather than simply having instrumental or operational control over it.” The two books also overlap in insights — and sometimes even in language. The reader who has learned in The Intelligibility of Nature that Buffon’s method of classifying animals “reflected his belief in the importance of the senses and empiricism in learning about nature (a doctrine associated with Newton and the philosopher John Locke)” will experience a sense of déjà vu on reading, in The World as We Know It, that the classification “reflects Buffon’s commitment to the epistemological stance of Newton and his philosophical underlaborer John Locke, who stressed the role of the senses in creating natural knowledge.” Later in the passage, we read that, “because of its stress on understanding the ways of life of animals in their environments, Buffon’s approach could almost be labeled (anachronistically) as ‘ecological.’” And again, “an anachronistic way of putting it would be to say that Buffon recommends an ecological mode of understanding.” Likewise, in The Intelligibility of Nature we read of Dalton that he was initially drawn to meteorology, and that: He did a bit of experimental work on these things, especially having to do with the water-holding capacity of gases, but his real interest lay in understanding what, at an underlying natural-philosophical level, was really going on physically.” Whereas, in The World as We Know It: He did experimental work on these things, especially concerning the water-holding capacity of gases — although not at a very refined level quantitatively — but he was continually trying to develop a theoretical conception of what was happening physically. The final full chapter of each book closes on the same resigned note. Intelligibility: These days, most serious work on the natural philosophical underpinnings and implications of quantum mechanics is performed not by physicists but by philosophers of science. Among scientific practitioners themselves, Bohr’s attempt to use instrumentality as sufficient grounds for a respectable science has met with a high degree of success. And again, in The World as We Know It: Bohr’s and Einstein’s concerns are now questions that are mostly discussed by philosophers of science rather than by physicists themselves. The marginalization of these sorts of questions amounts to the demise of natural philosophy, at least in physics, in the 20th century. Quantum mechanics “works,” and that’s good enough for most scientists who encounter it. Examples could be multiplied. When handling the same subject matter, some echoes are inevitable. Scholars should not feel that because they have written “Isaac Newton died in 1727” in one book, in the next they must describe him as perishing, expiring, or meeting his maker. But the repetitions of language and arguments (not to mention six reproduced images) threaded throughout The World as We Know It are more extensive than that. They should have been caught by Princeton University Press or its reviewers, and revised. Because the two books have so much in common, it is easy to see where they diverge. The World as We Know It is a less theoretical work than its predecessor. The sociology of knowledge that organized The Intelligibility of Nature has been reduced in scale and folded into readings and examples. The taut interplay between history and theory, which gave the earlier study so much interest, is there, but it is subtle. In the earlier book, the case studies demonstrated theoretical claims about the character and development of science. In the later work, each narrative of discovery is an end in itself. Insights emerge from the history, but they do not control the organization of the study. With the theory muted, it can be hard to understand the logic uniting Dear’s sprawling history of more than two centuries of scientific knowledge. The 16 brisk chapters cover an enormous amount of material. But the closer the volume edges to comprehensiveness, the more obvious the missing elements become. A chapter on “Institutions and Pedagogy,” describing the birth of the research university, illustrates the problem. Inserted roughly halfway through the book, the unnumbered chapter is designed as an “entr’acte,” in acknowledgement that it does not fit the study’s organization around scientific discoveries. Yet as Dear is well aware, no general history of the development of modern science can bracket its 19th-century institutionalization and professionalization. It was the 19th-century university, after all, that gave us the “scientist,” a term coined by the Cambridge philosopher William Whewell. Dear’s history of scientific discoveries implies a wider social and institutional history, but it remains largely subterranean, only occasionally extruded under the pressure of the narrative. It must be said that the balance is not all on the side of the earlier study. There are some advantages to the more historical, less theoretical organization of The World as We Know It. Dear’s accounts of paradigm shifts are remarkably lucid, no small accomplishment given that they span fields and centuries. He makes excellent use of the wealth of new scholarship on Darwin and his influences, to which he has himself contributed. It is satisfying to see puzzle pieces from Buffon’s natural history, Georges Cuvier’s animal taxonomy, Thomas Robert Malthus’s demography, and Charles Lyell’s geology recombined seamlessly in the Darwinian jigsaw. Likewise, Dear’s discussion of stellar nebulae, divided between chapters two and 15, shows vividly how Newton, Kant, Herschel, and Hubble reimagined insights and observations as they sought to discover whether the diffuse light that filtered through early telescopes was a glowing, gaseous substance or discrete but distant stars. Yet despite such pleasures, the book remains a more modest work than The Intelligibility of Nature. Dear has clearly not changed his views about the history of science. But in the two decades that have elapsed, the discipline and the world around it have changed, making it harder to write a sociologically and philosophically ambitious history of science for the general reader. That is a shame, because in the age of Silicon Valley and biotechnology, both the reciprocity and the tensions Dear identified between the epistemological and instrumental ambitions of science are more evident than ever. In recent years, some of the most exciting new books on the history of science in early modernity have focused precisely on this pressure point. Important studies such as Pamela H. Smith’s From Lived Experience to the Written Word (2022), James Poskett’s Horizons: The Global Origins of Modern Science (2022), and Vera Keller’s The Interlopers: Early Stuart Projects and the Undisciplining of Knowledge (2023) all shed new light on how early modern science negotiated the relationship between its instrumental and epistemological ambitions, or in Russell’s phrase, knowing and doing. There is every opportunity for a philosophically informed approach to draw new insights from this wealth of material. Dear, unfortunately, has not done so in The World as We Know It. But for future scholars of the history of science, his body of work over nearly four decades may provide just the model. Julianne Werlin is an associate professor of English at Duke University. Thanks for reading The Chronicle Review! Subscribe for free to receive new posts and support my work. Subscribe

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Oct 2 • 2:52 PM EDT • Science • chronicleofhighereducation.substack.com
Scientists seek new ways to protect Sierra Nevada meadows

Sierra Nevada meadows may cover a relatively small portion of the landscape, but scientists say they play an important role in supporting wildlife, storing water and maintaining biodiversity.

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Oct 2 • 2:44 PM EDT • Science • kunr.org
How Biotech AI And Robotics Bridge Bottlenecks To Impact Global Health

While biotech increasingly adopts AI for R&D, manufacturing bottlenecks constrain health innovation. AI and robotics have the potential to unlock health impact globally.

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Oct 2 • 2:33 PM EDT • Health • forbes.com
Colossal Biosciences' Ben Lamm on AI and the science of de-extinction

Ben Lamm, Colossal Biosciences Co-founder and CEO, told CNBC's Julia Boorstin at the 2026 CNBC AI Forum about how AI helps make "magic" happen when it comes to de-extinction.

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Oct 2 • 2:23 PM EDT • Science • cnbc.com
Merck business unit opens R&D facility in Sheboygan Falls

EMD Electronics, the North America electronics business unit of Germany-based global health care and biopharmaceutical company Merck KGaA, today announced

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Oct 2 • 1:32 PM EDT • Business • biztimes.com
The Oral Microbiome Trend Is Going Mainstream and the Science Behind It Is Compelling

Prebiotic toothpastes and microbiome rinses are going mainstream and dentists say the science backs them up.

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Oct 2 • 1:00 PM EDT • Science • charlotteobserver.com
People on the Move: Andy Fenny Named President of Pace Life Sciences

Pace Life Sciences, the life sciences division of science and technology company Pace, has named Andrew (Andy) Fenny as its President. “Pace Life Sciences has…

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Research uncovers how bacteria fight viruses, opening the door to better virus-based antibiotics

Bacteriophages are viruses that can attack harmful bacteria, whose "last resort" immune response kills the infected bacterium before the virus can spread to others.

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Oct 2 • 11:00 AM EDT • Health • attheu.utah.edu
Scientists Untangle the Biology of an ‘Undruggable’ Cancer Gene

Found in 70 percent of cancers, the gene is seen as a grand orchestrator but has been surprisingly difficult to stop.

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Oct 2 • 11:00 AM EDT • Science • nytimes.com
BioHealth Capital Region - Regional Life Sciences Roundup - October 2, 2026

Each week, our Regional Roundup delivers the most important and timely life sciences news from around the region. From groundbreaking research to fundraising…

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Oct 2 • 10:37 AM EDT • Science • biobuzz.io
BREAKING: Fabian Hurzeler Wins Premier League Manager Of The Month

Brighton's tactical maestro completes a clean sweep for the Albion

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Oct 2 • 8:12 AM EDT • Sports • sports.yahoo.com
BiomEdit acquires UK-based Folium Science

Company says the acquisition broadens its technology pipeline across animal health and nutrition.

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Oct 2 • 8:00 AM EDT • Science • vettimes.com
Proposition 134

Colorado voters will decide whether to designate athletic teams and sports from elementary all the way to college as male-only or female-only and require schools to ensure athletes are assigned to teams based on their biological sex.

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Oct 2 • 7:00 AM EDT • Politics • coloradopolitics.com
Four Life Science Startups Compete for the BioTools Innovator 2026 Award

After participating in BioTools Innovator’s four-month accelerator program, these finalists will contest on stage for a $250,000 prize during a capstone pitch event.

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Oct 2 • 12:00 AM EDT • Science • the-scientist.com
New biography on Ralph Wilson released
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SpyGlass Pharma Acquires Advanced Vision Science, Securing Commercial IOL Supply, Accelerating Lens Portfolio Expansion

IRVINE, Calif.—SpyGlass Pharma, Inc. (Nasdaq: SGP), a late-stage biopharmaceutical company focused on transforming treatment paradigms for patients with chronic eye conditions, has announced the acquisition of all the outstanding shares of common stock of Advanced Vision Science, Inc. (AVS), an ophthalmic medical device company and manufacturer of intraocular lenses (IOLs) and lens materials, for approximately $13 million in cash. This acquisition secures scalable commercial IOL supply and accelerates lens portfolio expansion capability for SpyGlass Pharma, the announcement noted.

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Oct 1 • 8:27 PM EDT • Science • visionmonday.com
Microbiome testing company Tiny Health clinches $33M to scale research, enterprise partnerships

Tiny Health, a microbiome testing company, has clinched $33 million in an oversubscribed series B round. | Alongside the funding news, Tiny announced the launch of a $5 million Microbiome Research Program to enable researchers, clinicians and scientific partners to investigate important intervention strategies in microbiome health.

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Oct 1 • 6:50 PM EDT • Health • fiercehealthcare.com
Wilson Sonsini Advises SpyGlass Pharma on Acquisition of Advanced Vision Science

On October 1, 2026, SpyGlass Pharma, a late-stage biopharmaceutical company dedicated to transforming the treatment paradigm for patients living with chronic eye conditions, announced the acquisition…

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Ten bucks says you’ll love this community science project

Today marks the first day of Rut Watch 2026 With another season of Deer Spy in the books thanks to community scientists like you, biologists are now on a mission to pinpoint the peak of the white-tailed deer breeding season in Maine. Every observation of deer breeding behavior and sign helps define the timing of the rut, and this project uses the power of community science to collect deer data all fall long. Hunters, hikers, and wildlife watchers - Rut Watch pairs well with any outdoor adventure you have planned this season. It’s a perfect excuse to slow down and connect with nature as you look for clues. So get outside, rack up that deer data and submit rut reports from now through December 1. The online form is science made simple: Location Date and time Breeding behavior observed Submit a Rut Report What to watch for Active Breeding The most obvious breeding behavior to observe is a buck mounting a doe, but that is a rare sight as it only lasts a moment. You are more likely to witness a buck “tending” a doe, following closely, chasing, nuzzling, or pawing at her rump until she is receptive. Sparring After bucks shed their velvet, sparring helps sort out who is who in the dominance hierarchy. Early season matches are often less intense than later season matches between similar sized bucks. Most sparring is complete by the time breeding begins. Rubs Don’t just look for deer, pay attention to the trees. Rubs are marks made by bucks when they rub their antlers on trees, removing bark and leaving their scent calling card in the process. Scrapes Look to the forest floor for this sign of breeding season behavior. Scrapes consist of two parts - a licking branch, and a patch of cleared earth. Bucks break a low branch around head height, then paw at the leaves below to expose the dirt. Covered in scent, a scrape tells does and other bucks, “I’m here!” Learn More More information What’s next for deer community science: Northern Maine Wintering Deer Survey Other active community science projects: Fish Tag Reporting Maine Golden Eagle Study Maine Amphibian & Reptile Atlas Project Maine Deer Management: Maine’s Big Game Management Plan Game Species Conservation & Management Report The Benefits of Hunting: Supporting Wildlife, Conservation, and Community Subscribe Share Leave a comment

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Oct 1 • 4:33 PM EDT • Science • barharborstory.substack.com
Scientists Found a “Third State” Of Being Between Life and Death

Frog and human cells can reorganize after removal from their host, raising open questions about biological death and potential uses in regenerative medicine.

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Oct 1 • 2:27 PM EDT • Science • yahoo.com
How sex chromosomes influence lifelong health beyond determining biological sex

A new review published in Science brings together growing evidence that the X and Y chromosomes do more than determine biological sex. They also shape how cells function, age and respond to disease.

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Oct 1 • 2:00 PM EDT • Health • medicalxpress.com
This AI Scientist Can Design Experiments, Run Them in the Lab and Learn From the Results

The system can propose biological questions, design experiments and send robots to test them.

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Oct 1 • 1:26 PM EDT • Science • zmescience.com
Neuroscience launches seminar series with talk on brain circuitry by renowned neurobiologist Peter Strick P’98

The Bates Program in Neuroscience kicked off its new Neuroscience Seminar Series with a talk from Peter Strick P’98, Thomas Detre Professor and Chair of Neurobiology at the University of Pittsburgh.

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Oct 1 • 1:00 PM EDT • Science • bates.edu
What Could Brighton Achieve This Season?

A strong summer, a good start and some serious togetherness... Can Albion dare to dream?

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Oct 1 • 10:12 AM EDT • Sports • sports.yahoo.com
Mount Sinai and Hasso Plattner Institute Launch International Graduate Student Exchange Program to Advance Digital Health and AI Innovation

The Icahn School of Medicine at Mount Sinai and the Hasso Plattner Institute for Digital Engineering (HPI) are expanding their academic collaboration in digital health through the launch of a new graduate student exchange program offered through Mount Sinai’s Graduate School of Biomedical Sciences.

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Oct 1 • 10:05 AM EDT • Health • newswise.com
Greater Philadelphia - Regional Life Sciences Roundup - October 1, 2026

Each week, our Regional Roundup delivers the most important and timely life sciences news from around the region. From groundbreaking research to fundraising…

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Oct 1 • 9:37 AM EDT • Science • biobuzz.io
100 years ago, Schrödinger’s equation shed light on quantum physics – scientists use it today to fine-tune chemical reactions

A 100-year-old equation helps scientists build solar cells, develop biofuels and even study quantum computers.

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Oct 1 • 9:04 AM EDT • Science • yahoo.com
Xtalks Announces its Life Science Webinar Calendar for October 2026

Stay on top of current hot topics through free webinars presented by leading experts in the pharma, biotech, medical device and food industries. Access to all webinars is free, so be sure to register today to save your place! Participate in the discussion and stay relevant in your field!

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Oct 1 • 8:25 AM EDT • Science • finance.yahoo.com
Xtalks Announces its Life Science Webinar Calendar for October 2026

/PRNewswire/ -- Stay on top of current hot topics through free webinars presented by leading experts in the pharma, biotech, medical device and food industries....

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Oct 1 • 8:25 AM EDT • Science • prnewswire.com
This giant stick insect fooled scientists for decades

Scientists have identified two new species of large Australian stick insects, including one that lays extraordinary “lidded” eggs never before recorded in the group. The discovery also revealed that a familiar stick insect had been misidentified for decades, showing how much biodiversity may still be hiding in plain sight.

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Oct 1 • 8:00 AM EDT • Science • sciencedaily.com
Research station will explore how Bloedel's nature affects our health

The University of Washington Center for Nature and Health is set to begin installation of a biological research station aimed to explore the connection between human health and physiological response to nature.

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Oct 1 • 7:05 AM EDT • Health • thenewstribune.com
Here’s the newest faculty members of LSU’s College of Science

Three assistant professors have joined LSU’s College of Science this semester. Carl Procko, Ping Wang and Keegan Kirk brought their research expertise, including plant responses, adaptations and numerical analysis. Procko, assistant professor of biological sciences, works with the adaptations of plants in relation to their environments. He mentioned his interest in unusual plants, including carnivorous...

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Oct 1 • 7:00 AM EDT • Science • lsureveille.com
Earth Has Breached 7 Of 9 Planetary Boundaries, Scientists Warn

Seven of Earth's nine planetary boundaries have now been breached, with scientists warning that growing pressure on climate, biodiversity, freshwater and other natural systems is increasing the risk of irreversible environmental changes.

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Oct 1 • 6:04 AM EDT • Science • ndtv.com
Proposition 134: Colorado voters asked to ban transgender kids from gendered sports

The measure would require that kids from kindergarten through college play on school sports teams that match their biological sex, not their preferred gender

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Oct 1 • 6:00 AM EDT • Sports • coloradosun.com
In Shanghai's 'Science City,' China's ascendant biotechs make their pitch to the world

A small conference with big ambitions mirrors the rapid growth of Chinese biotech, invites comparisons to U.S. biotech gathering also known for deal-making.

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Oct 1 • 4:30 AM EDT • Science • statnews.com
Baylor debuts new health programs at annual Career Day event

At this year's event, brand-new graduate health programs, including master's programs in Bioethics and Health Data Analytics, were featured to undergraduates for the first time.

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Oct 1 • 12:39 AM EDT • Health • baylorlariat.com
Rubio orders visiting Iranian UN delegation to leave NYC ahead of schedule

WASHINGTON (AP) — Secretary of State Marco Rubio ordered Iran’s foreign minister and his delegation to the U.N. General Assembly to leave New York earlier than

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Sep 30 • 10:17 PM EDT • Politics • wtop.com
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UNR launches animal science program to keep students in-state

University of Nevada, Reno launches a new bachelor's degree in animal science to train students for livestock and biotech careers.

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Sep 30 • 6:00 PM EDT • Science • thisisreno.com
Microsoft Pushes AI Deeper Into Scientific Discovery With Quine

AI can already help scientists make sense of large amounts of data. Microsoft Research is now testing whether it can play a bigger role in deciding what scientists should investigate next. Its new experimental system, Quine, brings together biological data, computational models and research tools to make predictions that researchers can put to the test […]

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Sep 30 • 3:29 PM EDT • Science • hpcwire.com
Sugar Amplifies Damage Done to Gut Health by Antibiotics

/PRNewswire/ -- Eating sweets while taking antibiotics may worsen the harm done by the drugs to the normal community of bacteria in the gut, a new study found....

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Sep 30 • 11:11 AM EDT • Health • prnewswire.com
Slashing sugar intake before antibiotics may save your microbiome

Antibiotics can reduce the diversity of microbes in your gut microbiome and lead to health problems, but a study in people with cancer has identified a potential solution

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Sep 30 • 11:00 AM EDT • Health • newscientist.com
BioMed to Land $915M for Life Science Asset

BioMed will soon secure a $915 million mortgage loan for 585 Kendall, a life science property in Cambridge, Mass.

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Sep 30 • 9:44 AM EDT • Science • commercialsearch.com
Biokineticists fight disease using exercise science: how to bring their skills to rural patients

Biokineticists can help identify NCD risk in rural communities, but gaps in referral pathways and public healthcare integration may limit access to follow-up care.

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Sep 30 • 9:25 AM EDT • Science • theconversation.com
An MIT-Trained Engineer Spent 5 Years Using Science to Rethink How We Smell

Jasmina Aganovic is using science to rethink personal scent, turning biology and tech into a beauty product with Future Society’s Base Scent.

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Sep 30 • 9:00 AM EDT • Science • inc.com
Tottenham, Brighton and Everton monitoring Eintracht Frankfurt and Germany forward

Eintracht Frankfurt forward Younes Ebnoutalib has reportedly emerged as a transfer target for three Premier League clubs.According to a report from TEAMtalk, Tottenham, Brighton & Hove Albion and Ever...

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Sep 30 • 8:23 AM EDT • Sports • sports.yahoo.com
Minaris Adds Dedicated Viral Vectors Business Unit, Splitting Into Three Specialized Divisions

Minaris, the Philadelphia-based global cell and gene therapy CDMO and multimodal contract testing organization, announced on September 29, 2026 the addition…

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Sep 30 • 8:15 AM EDT • Business • biobuzz.io
OBIO marks $1bn funding milestone for Canadian health tech ventures

Life sciences and technology companies supported by the OBIO's CAAP have collectively raised more than $1bn in capital.

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Sep 30 • 5:52 AM EDT • Health • pharmaceutical-technology.com
Discover the latest science on probiotics for healthy ageing: From longevity to quality of life

As healthy aging shifts from longevity to quality of life, new research highlights the gut microbiome as a key lever for supporting mobility, muscle function and independence in aging populations

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Sep 30 • 2:01 AM EDT • Science • nutraceuticalbusinessreview.com
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A Microbiologist Dissects the Science of Infection in Movies

An infection control scientist binge-watches decades of outbreaks, pathogens, and pandemic drama to find out which shows and films hit the mark with infections.

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Sep 30 • 12:00 AM EDT • Science • the-scientist.com
Catching the Light: Taking the Pulse of Puerto Rico’s Forests

Our team from NASA Goddard Space Flight Center’s Biospheric Sciences Laboratory is working to improve how satellites monitor plant health.

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Sep 29 • 4:15 PM EDT • Science • science.nasa.gov
Tahoma High School Biomedical Science and Intro to Acting  : VOICE of the Valley

Two very different THS classes — Biomedical Science and Intro to Acting — collaborated last week on a unique, hands-on assignment! Students in this senior-level biomedical class are learning how to triage patients in emergency situations. So, students in the drama class acted as car crash victims — some with injuries, some dead. It was […]

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Sep 29 • 3:02 PM EDT • Science • voiceofthevalley.com
Satisfactory DLC Core Values will introduce cavernous constraints through new underground biomes

Core Values is Satisfactory's first "major expansion" and will sport a wealth of new factory buildings, tools, and creatures from the depths.

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Sep 29 • 2:30 PM EDT • Technology • pcgamesn.com
Among the Academies: A Lifelong Fascination with Fish

For Peter Wainwright, the academic path was simple: he simply followed his fascination with fish."I dare say there wasn't a lot of deep thought about what direction I should go in my life," he said. "It was more, I like fish, let's see if I can do something with fish. It was all very organic."

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Sep 29 • 2:18 PM EDT • Science • biology.ucdavis.edu
Domino Data Lab and EPAM Partner to Accelerate AI Adoption in Life Sciences

Combines Domino’s enterprise platform with EPAM’s global engineering to scale compliant AI applications and advanced analytics across global biopharma SAN FRANCISCO, Sept. 29, 2026 — Domino Data Lab, provider of the unified platform to build, scale, and govern enterprise AI solutions for the most consequential industries, today announced a strategic partnership with EPAM, a leading […]

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Sep 29 • 2:16 PM EDT • Science • hpcwire.com
State Department to launch online-only first passport applications in December

First-time applications can be submitted through America.gov

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Sep 29 • 2:14 PM EDT • Politics • spectrumlocalnews.com
Queen Latifah Says Biopic May Need 3 People to Play Her

The hip-hop icon wants performers who can capture her journey from Dana Owens to Grammy winner, Oscar nominee, producer, and entrepreneur.

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Sep 29 • 11:13 AM EDT • Entertainment • yahoo.com
Waltz Health and Fresenius Kabi Expand Direct Access to Biosimilars Through Waltz Connect Platform

/PRNewswire/ -- Waltz Health®, an EVERSANA® company developing technologies and services that support better-informed decisions on prescription care and...

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Sep 29 • 9:00 AM EDT • Health • prnewswire.com
High-Impact Experience: Getting Research Ready

With support from NC State's Packways High-Impact Experiences initiative, the Biochemistry Undergraduate Research and Training Program now offers students an experience with greater structure and intention.

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Sep 29 • 8:34 AM EDT • Science • cals.ncsu.edu
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Tiny Health Raises $33M To Explore What Gut Data Can Reveal About Future Health

Austin-based Tiny Health has raised $33 million in a Series B funding round led by B Capital to help it meet growing demand for its at-home microbiome tests.

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Sep 29 • 8:30 AM EDT • Health • news.crunchbase.com
The Beclowning of Scott Bessent

One iron law of current politics is that nobody who associates themselves with Donald Trump emerges with a shred of credibility. For some, that’s not a big loss — it’s not as if anyone respected Pete Hegseth even before he decided that the key to military success in an age of drones and AI was more testosterone. For others, however, the costs are real. I’m old enough to remember when Marco Rubio was widely considered a reasonable, thoughtful politician. Right now, however, my candidate for the biggest loser is Scott Bessent, the Secretary of the Treasury. Bessent started out with significant reputation to lose: When Trump selected him, this was the headline in the Financial Times: Jason Furman, Barack Obama’s chief economist, described him as a “credible Treasury secretary who has a real understanding of the global economy”. But Bessent has now transformed himself into the Baghdad Bob of bonds. Three weeks ago, after intervening (for reasons that remain somewhat unclear) to support the Japanese yen, Bessent boasted about his ability to move markets and dared investors to bet against his, declaring “I am the house now.” He then tried to push long-term interest rates down, buying 30-year U.S. Treasuries in a move some have compared to paying down part of your mortgage by running up your credit card balance. Here’s how that’s going so far: To get some perspective on how high interest rates have gone, here’s a longer-term perspective: We haven’t seen interest rates this high since the fading days of the dotcom bubble. Why are interest rates hitting new records? The backdrop, as I argued in last Sunday’s primer, is the huge AI-driven investment boom; more on that next week. But the immediate cause of the latest interest rate spike was Trump’s rejection of an Iranian proposal to end the war. This rejection sent crude oil prices, which for a while had fallen considerably, shooting back up: It’s notable, by the way, that oil prices remain high even though a significant amount of oil is now being shuttled through the Strait of Hormuz by night, on smaller vessels. That’s an interesting story, which has a lot to do with the fact that oil from the Hormuz shuttle runs must be transferred to larger vessels before being shipped to markets in Europe and Asia; around 15 percent of the world’s large crude carriers are now parked off the coast of Oman, waiting to be tanked up. This is creating a shipping crunch: But that’s a topic for another day. For now, the point is that with oil still high and refined products, especially diesel, still close to record levels, inflation will remain elevated. And this in turn means that the Federal Reserve will keep short-term interest rates high, an expectation that is feeding into longer-term rates. Hence Bessent’s bond-market humiliation. The truth is that Bessent might not have been able to get interest rates down even in the best of circumstances. But he certainly won’t get anywhere as long as Trump keeps believing that he can somehow convert his Iran debacle into a triumphant victory. And Trump will keep believing that as long as he is surrounded by sycophants who tell him what he wants to hear. Sycophants like, for example, Scott Bessent, who is predicting the imminent collapse of the Iranian economy, possibly within two weeks. Bessent is right to say that the embargo on Iranian oil exports is placing the country under great economic strain. But his implicit prediction that this will quickly produce a deal that Trump can call victory looks no more plausible than his boasts about the bond market. The big question now is, why would anyone with a reputation to lose work for Donald Trump? As the beclowning of Bessent shows, joining the Trump team won’t just damage your reputation; it will utterly destroy it.

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Sep 29 • 7:10 AM EDT • Politics • paulkrugman.substack.com
Caris Life Sciences Unveils the Next Evolution of Liquid Biopsy with Enhanced Caris Assure

/PRNewswire/ -- Caris Life Sciences® (Caris), a leading AI TechBio company, today unveiled the enhanced Caris Assure®, a new evolution of liquid biopsy. By...

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Sep 29 • 6:30 AM EDT • Science • prnewswire.com
Primetime Review: That’s Entertainment?

If you decide to see Lance Oppenheim’s Primetime, it’s important to remember the title as you watch. Yes, this is a biopic of sorts about Chris Hansen and his work on To Catch a Predator, but it is more accurately about the quest for fame and using people’s trauma to attract ratings. True crime entertainment continues to have a prominent place in many people’s television habits, and this film asks us to examine what that means both for those whose stories have become our viewing pleasure and those of us watching. Primetime starts as Chris Hansen (Robert Pattinson) is told that his show, To Catch a Predator, is moving to a 9 PM spot opposite LOST. Chris and his producer, Andie (Merritt Wever), see this as an opportunity to make the program even more sensational, looking for bigger, more horrific predators. As part of their plan, they hire a young actor, Dan Plum (Skyler Gisondo), to play “Decoy Dan,” the person who greets the would-be predators who were catfished by Xavier Von Erck (Matthew Maher). Oppenheim, along with writers Ajon Singh and Luke Dittrich, is less concerned with an accurate retelling of the show as much as they are interested in interrogating the why of it all. That decision sometimes leaves Primetime feeling less like a biopic and more like a satirical look at the nature of programming like this. Visually, the movie is impressive. Oppenheim uses light and color effectively to cast Hansen as both villain and savior. Pattinson plays Hansen in an almost comical manner, as we see him wake his two young sons to watch a clip of the show, just to brag that he was moving into a prime spot on television. Even Andie struggles to accept a “nice” job when there is so much more fame to be found producing salacious true-crime content. Wever does an excellent job showing how the hunger for fame is not just in front of the camera, but in every aspect of the production. The heart of the movie, and the standout performance, belongs to Gisondo as Dan Plum. He is someone who just wants to get enough hours to be admitted into the Screen Actors Guild, and stumbles into this job without really knowing what it is. Throughout the film, we watch him suffer one trauma after another, ending with him witnessing the suicide of a District Attorney who is about to become the next unwitting star of Hansen’s show. If there is a sympathetic character in Primetime, it is Decoy Dan, and Gisondo plays him brilliantly. If you’re a fan of programming like To Catch a Predator, then Primetime will probably make you feel uncomfortable, and I think it’s worth sitting with that feeling and examining why we turn on shows that display the worst of humanity while we judge from our couches. Yes, it is correct to want to see people who would hurt children brought to justice, but perhaps it shouldn’t be something that we watch as entertainment. Rating: 3.5/5 This review originally appeared in The Dominion Post on September 25, 2026. MacGuffin or Meaning: Film & TV Reviews and Reflections is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

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Sep 29 • 5:37 AM EDT • Entertainment • alisechaffins.substack.com
From wild rice to tarwi, researchers are exploring the health potential of Indigenous foods

A conference paper reviewed North American and Andean Indigenous foods, including Three Sisters crops, wild rice, native berries, tarwi, quinoa, and amaranth, and described their nutrients and bioactive compounds. Evidence for health effects remains limited for many of these foods, and the authors call for research developed with Indigenous communities that also supports traditional knowledge and food sovereignty.

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Sep 28 • 11:49 PM EDT • Health • news-medical.net
Ethics Watchdogs To Investigate Whether Troubled Multnomah County Health Board Got Dubious Legal Advice

A Washington state attorney has been advising a Portland-area governance board on Oregon Public Meetings Law.

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Sep 28 • 9:17 PM EDT • Health • wweek.com
The Philosophy of Organizational Politics 2.0

Editor’s Note: This article is Part II of “The Philosophy of Organizational Politics: Power, Legitimacy, and the Integrity of Mission,” previously published in Oragark. We Are Not in Competition With Anyone: Conviction, Power, and the Purpose of Leadership By Dr. Prof. M. Mkhitar Moradian, PhD Bioanalyst In organizations some factions make

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Sep 28 • 8:42 PM EDT • Politics • oragark.com
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What If the Coffee Grounds We Throw Away Could Help Insulate Our Homes?

The grounds left behind from your daily cup of coffee could one day help insulate buildings. Scientists transformed spent coffee grounds into biodegradable biochar insulation that performs about as well as commercial foam. The material could give mountains of coffee waste a useful second life while helping reduce energy use. Now, researchers are working to determine how well it holds up over time.

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Sep 28 • 8:00 PM EDT • Science • foodandwine.com
Battle over progressive politics pits blue vs blue in this Seattle legislative district

Incumbent Sen. Jamie Pedersen and challenger Hannah Sabio-Howell talked to "Soundside" about their campaigns to represent the city's progressive district.

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Sep 28 • 7:24 PM EDT • Politics • kuow.org
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Bioblitz: Lakeshore Nature Preserve utilizes citizen science to document biodiversity

The University of Wisconsin Lakeshore Nature Preserve hosted its second annual Bioblitz event Sept. 26. The goal of the event was to document as many species at the preserve as possible over a 15-hour period, according to Lakeshore Nature Preserve Director Brad Herrick. With this documentation of everything within the 300-acre area, the preserve aims...

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Sep 28 • 6:47 PM EDT • Science • badgerherald.com
AI is everywhere. Should you use it for health advice?

The following expert commentary can be used by journalists and media organizations in their own publications and news coverage. Please attribute all quotes to Xiaoqian Jiang, PhD, chair of the Department of Health Data Science and Artificial Intelligence at McWilliams School of Biomedical Informatics at UTHealth Houston.

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Sep 28 • 6:05 PM EDT • Health • newswise.com
The Next Bioweapon Could Attack Our Genes Instead of Our Bodies. I Promise You We’re Not Ready for That.

The most devastating weapons conceived by humanity cause cellular damage as a side effect. What would happen if the genetic mutation itself were the nefarious goal?

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Sep 28 • 4:36 PM EDT • Science • popularmechanics.com
Behind the Science with Paleontologist and Curator of Dinosauria Dr. Matthew Carrano

Is the 21st Century the real Age of Dinosaurs? Today, more paleontologists are discovering more dinosaur fossils from more places in the world than ever before. Our understanding of these amazing creatures has leapt forward while their popularity has surged. Museums sit at the junction of these phenomena. The Smithsonian has been a center for dinosaur research for more than a century, and its collections include many iconic and scientifically important specimens. Today, Smithsonian researchers continue to discover new dinosaurs, but they are also uncovering more information about the ones we already know and love. New techniques and approaches allow them to investigate aspects of dinosaur biology, ecology, and evolution in ways that would have been inconceivable to early paleontologists. The result is an ever-improving understanding of dinosaurs as living, breathing, and thriving animals. This month, go behind the science with paleontologist Dr. Matthew Carrano, Curator of Dinosauria at the National Museum of Natural History as he discusses new discoveries at home and abroad, in the field and in the museum. Registration is encouraged. Space is filled on a first come first served basis. ---------------- About the Series: Behind the Science A monthly after-hours series featuring NMNH scientists and researchers Each month, join the National Museum of Natural History for the new series, Behind the Science, where NMNH researchers share insights into their latest discoveries and explore the fascinating questions driving their work—from the origins of life to the future of our planet. Come learn what’s happening behind the scenes and how science shapes our understanding of the natural world. Programs take place in Q?rius, the Coralyn W. Whitney Science Education Center. Topics and speakers announced on a rolling basis, but save the dates now!

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Sep 28 • 3:40 PM EDT • Science • naturalhistory.si.edu
Mahony named Huck Chair in Genomics and AI

Shaun Mahony, professor of biochemistry and molecular biology in the Penn State Eberly College of Science, has been named the Dorothy Foehr Huck and J. Lloyd Huck Chair in Genomics and AI.

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Sep 28 • 3:14 PM EDT • Science • psu.edu