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In Retrospect: Poland, Russia, Europe

In April I spent a few days with Zryw, a Polish non-profit organization that recruits young people to enter politics and public life. Their aim is to build a new generation of civic leaders in Poland. I’ve followed their evolution from the beginning; my son is one of the founders. (“Zryw” means “impulse” or “burst of speed” in Polish). Julie Chmielewska, one of Zryw’s leaders, interviewed me at the event. Here is the conversation, lightly edited for grammar and context: Julia Chmielewska: Assuming that culture shapes institutions, could we conclude that some cultures are more prone to authoritarianism? Anne Applebaum: I don’t think so. Every culture, every nation, and every country has the potential for change. When we look at history, we can see that nations do change. Poland has changed, for example, from the 1980s to today. There’s a completely different mentality here than the one I encountered when I first visited, in 1988. The current generation sees the world through a different frame. So no, I don’t believe that certain nations are doomed to authoritarianism, or to anything. Of course, there are political and cultural traditions, but they can always be challenged. JC: So do you think there’s something intrinsic in human nature that pushes people to democracy, freedom? AA: I think there is something in human nature, a deep instinct, that pushes people towards freedom, yes. People who live in authoritarian countries – and I’ve heard this from them over and over again – sooner or later find themselves angered by a feeling of helplessness. They can see the unfairness of crooked courts, irrational political decisions. They naturally dislike the fact that somebody has all the power while they have none. In those circumstances, people who have no political background at all sometimes are politicized just by that frustration. I’m thinking of Svetlana Tikhanovskaya, for example, who was a Belarusian housewife, until the circumstances of her husband’s arrest forced her to become a politician. I met a woman who is a Uyghur from China, and who had come to live in Turkey. After several of her family members were arrested, she too was propelled into a political role. These kinds of experiences make people interested in democracy or political reform, even if they thought they didn’t care. I also think that the opposite is true: some people instinctively prefer homogeneity, order, hierarchy. They don’t like the confrontation of opinions or the noise of debate, and they lean towards a single leader or a unified regime. I think that most of modern history is shaped by the clash between those two different sides of human nature. JC: Which force do you find more powerful today? AA: I think they both have a lot of power and there’s no way of predicting who wins. Even in countries that seem very shut off or stuck in an authoritarian system can change. We’ve seen that happen. And vice versa, I think democracies can also begin to fail and slide into authoritarianism. So it’s very important not to be complacent in either direction. JC: I want to go into your history and your experiences. You’ve lived in Russia during a time of incredible change in the late 80s, and then you came back to do research in post-Soviet Russia. AA: I was a student in Russia just before the collapse of the Soviet Union. I then traveled and worked there extensively in the 1990s, and I met people who really were full of hope. They hoped that Russia could become a democracy, or at least a place that guaranteed freedom of speech, freedom of the press. These weren’t ideas that came from Washington. Although now the narrative in the Kremlin is different, I met many people who were working towards exactly that kind of transformation. A friend of mine ran a series of seminars – once a year, and then later several times a year, in cities all over Russia – designed to get people to discuss politics in new ways. She invited young politicians and journalists, as well as foreigners. I went to many of them, in Moscow as well as Volgograd and Novosibirsk. Over two decades, hundreds of people came to these seminars, and all of them wanted Russia to be different. I remain convinced that many Russians still want Russia to be different. It’s just that the old system, in the form of Putin, a representative of that system, returned. The KGB reimposed their power. And this wasn’t because of something to do with culture, this was to do with money and politics, and who was in charge. JC: You’ve partially answered my question... I wanted to ask whether that excitement of the 1990s was an exception from the Russian historical norm which has been rather authoritarian? AA: Of course, if you look at the history of Russia since the 18th century, there have always been liberal groups, reformers and revolutionaries. There were the Decembrists, in the early 19th century, and the rural populists later on, who tried to organize the peasantry. A significant group of liberal Russians appeared at the turn of the 20th century, people like the father of the writer Vladimir Nabokov, who was a Russian politician before the revolution. These groups were small in number, but sometimes had a broader significance. The Russian dissident movement in the 1950s and 1960s actually invented the modern human rights movement. It was their idea to hold the leaders of the Soviet Union accountable for the language they used, to remind them of the treaties they had signed and the promised they had made. They created the Helsinki group, for example, that held Soviet leadership to the language of the Helsinki Treaty, which formally ended the Second World War and which contained guarantees of human rights, at least on paper. That idea spread to Eastern Europe, and similar tactics were used here in Poland. (Benjamin Nathans recently wrote a great book about the Soviet dissidents, To the Success of Our Hopeless Cause) JC: But seemingly, even if they do ever get power, they could never hold on to it. AA: We don’t know, because they have never really had power. But in any case, we also don’t know what will happen in the future. There is no reason to assume that Russia will forever be condemned to totalitarianism. Even during the first fifteen years of Putin’s regime there was some form of democratic politics. Only when the full-scale war began did he bring everything to an end: he shut down all remaining independent organizations and killed his most important opponent, Alexi Navalny. But does that mean he is popular, that he enjoys legitimacy? Even now, we don’t really know what Russians think about him, or about the war. There is no way of doing real polling in Russia because nobody will answer an independent pollster over the phone. JC: Do you think that the flock of young people, especially young men, who fled Russia after the start of the war represent a continuation of liberal movements that refuse to partake in the authoritarian state, or do you think they are moving for the sake of self-preservation – “I don’t want to go to the army, so I leave”? AA: I’m sure it’s both. I actually know many people who left Russia for political reasons either in the very last years before the war, or else just after the war began. JC: And do you see a change in the young generation versus the old one that have fled? AA: It’s hard for me to say because the people who I know were mostly already politicized. I do know some younger people who left, but most of them were already either active in the opposition, or working as journalists. Many of them very self-consciously think of themselves as maintaining Russian culture abroad, just as in the 20th century the Soviet dissidents or the anti-communist White Russians once thought of themselves as people who maintained the true Russian culture, outside of Bolshevik Russia. JC: Let’s move on to Poland. One of your first experiences with Poland was reporting on Margaret Thatcher’s first state visit, in the autumn of 1988. You followed her around the farmers’ market. AA: She was making a symbolic gesture. She wanted to welcome free markets, but the only one she could really visit was the farmers’ market at Hala Mirowska. JC: And I want to talk about this area because today you can look out of any window in that district, Mirów, and see rows and rows of skyscrapers. How does it feel to see a country built from the ground in such a short time, both politically and economically? AA: You know, when you’re living in a period of dramatic change, it’s always hard to know whether the change is positive or negative. The transformation in Poland created winners and losers, as well as new classes of people, new political movements of different kinds. At the time, it sometimes just felt like turbulence. Now, we can look back at the 1990s and early 2000s in Poland and see in retrospect that the country was headed in towards prosperity and European integration. In around 2009 or 2010, I remember speaking to a woman who worked cleaning government offices, and who asked me if her daughter should study in Amsterdam or in London. This seemed to me to be a real transformation, and it happened very fast: within a few years, Poles stopped feeling like second-class Europeans, and a generation of younger Poles appeared who had no qualms about crossing borders. JC: We again live in turbulent times. Do you think we’re heading towards positive outcomes? AA: I can’t make predictions, because everything that happens tomorrow depends on what people do today. Also, history doesn’t have a trajectory. It doesn’t move in a particular direction. You only think it does afterwards. As I said, you can look afterwards at Poland in the 1990s and you could say this was a period of great progress. But not everybody at the time saw that. Sometimes people are very wrong about a given country’s trajectory. I remember people writing about Ukraine in the 1990s, about how dangerous it was that Ukraine was independent, that this was going to be an anti-semitic state, that Ukrainian nationalism was going to come back... and although you can say many bad things about Ukraine, the country made many bad choices, actually it became a pretty tolerant state which now has a Jewish president and until recently a Muslim defense minister. JC: In the 1990s Poland’s and Ukraine’s GDP were roughly similar. Ukraine was even a bit richer. So the starting point was similar for both of these countries, but they’ve turned out very, very differently. Even if we stop in 2014. Why do you think Ukraine “chose East”? Was it external influence? AA: No, I think Ukraine was in a different position. First of all, central and eastern Ukraine had been part of the Soviet Union since the 1920s, and had therefore experienced a longer period of occupation, repression, Sovietization and even Russification. Ukraine did not have, as Poland did, an alternative elite: a large cadre of economists and politicians, who already had some experience in opposition politics and in independent thinking. In Poland, the transformative finance minister, Leszek Balcerowicz, had already thought about how an economy might be decentralized before he took office. We can argue about how successful he was, but at least he was prepared to try something new. In Ukraine, people weren’t prepared. For one, there hadn’t been much space even for an illegal opposition in the previous couple of decades. Ukraine was also in many ways still emerging from colonial occupation. For the previous couple of centuries, many of the most capable Ukrainians had moved to Russia, and the first generation of leaders in independent Ukraine tended to be former Soviet apparatchiks. They didn’t immediately seek to become closer to western Europe. Instead, they looked for some kind of economic and political “third way” and an accomodation with Russia. Ukraine became stuck in this position, half-in, half-out and became pretty profoundly corrupt. JC: The Polish alternative elite had a vision of where they wanted the country to go. I think the general perception now is that this vision ends with the next election, right? Is this a natural process of gaining power? AA: Their vision, and it was shared by the time by politicians who now call themselves both left and right, was that Poland should join the EU and NATO, as fast as possible. My husband (Radek Sikorski) was in the very first government that said it wanted to join NATO. At the time this was taken very badly in Washington: the demand for NATO membership absolutely came from Poland, not from the US. But even then, in the early 1990s, many Poles already understood that the Russian sphere of influence would grow once again, that it was important to become part of the transatlantic alliance and an integrated Europe as fast as possible: NATO, the EU, the Council of Europe, all of the trading and security alliances. That consensus lasted through several different governments and over many years, even governments containing former communists. For twenty years, right, left and center disagreed about many things, but they all agreed on the direction that the country should go. In retrospect, that consensus created the basis for prosperity in Poland. JC: And regarding the Polish-Ukrainian relations. We know that antagonisms, e.g. the myth of Wołyń [a massacre of Poles that took place in what is now Western Ukraine, in 1943] are increasingly used in Polish political discourse today. In Ukraine, nationalist historians make heroes out of UPA, the Ukrainian revolutionary army, which is held responsible for this tragedy. Where do you see a start for burying the hatchet? Is the reconciliation of our nations possible? AA: So here’s a strange thing: For more than a decade after they both gained independence, Poland and Ukraine participated in a number of projects that were designed to solve exactly these kinds of Polish-Ukrainian differences. Books were published that were jointly written by Polish and Ukrainian historians, monuments were built. These projects were successful: If you’d asked me this question in 2010, I would have said that there are no real historical issues between Poland and Ukraine, that the two countries had mostly reconciled. For a number of reasons, this began to shift. In Poland, children and grandchildren of victims of the Wołyń massacre felt their tragedy hadn’t been fully recognized. In Ukraine, nationalist groups wanted the UPA partisans who had fought against the Soviet Union recognized for their heroism, despite the fact that some in this broad and not well-defined group were also linked to Wołyń. In both eastern Poland and western Ukraine, the memory of the ethnic cleansing that took place there in the late 1940s - Poles were moved West, Ukrainians East - to accomodate new borders has left feelings of displacement and bitterness. The wave of Ukrainian immigration, which started before the war, may have provoked some of this. But don’t underestimate the role played by Russia, which has always wanted to create discord between Poland and Ukraine, and pumps out propaganda to that effect in both countries. Vandalism on both sides of the border, damage done to cemeteries and monuments, is sometimes carried out by provacateurs working for Russia, just to create bad feelings. The Polish-Ukrainian conflict also hides a different reality: although there are real grievances and bad memories, the truth is that the biggest tragedies both nations experienced in the twentieth century were inflicted by the Soviet Union and Nazi Germany. That should unite these two countries, not divide them. JC: This week (19.04.2026 – Ed.) in Hungary we saw that using historical narratives to create grievance has no longer worked. Are you optimistic about the direction after Orban’s loss? AA: The Hungarian election was really important because it shows that people can actually resist powerful, dominant propaganda. The ruling party Fidesz controlled all of the TV, 90% of the newspapers, the constitutional court, the bureaucracy... and yet people had the nerve to vote against it and resist it. It’s also an important election because Hungary created a huge network of well-funded think tanks and foundations that were funding other far right groups and projects. So that loss is going to have a knock-on effect in other places too, maybe even in Poland. JC: What you’ve said about resisting propaganda reminds me of one of the interviews you did about talking to Russians in the post-Soviet era who claimed that people knew that the system was lying. Why do people choose to believe in these regimes anyway? AA: Because it’s useful. Stephen Kotkin, an American historian, once described how people would learn how to “speak Bolshevik”: It was just a language that you needed to use in order to get by in society. If you didn’t talk the way the regime wanted you to talk, then you might have problems, or lose your job, or your kids would not get into university. It was a way of getting along. Communist Poland was similar, at least in the early years. When I was writing a book about the Sovietization of Eastern Europe after World War II, I met a lot of people who wanted to talk a lot about the war, when many of them had done really heroic things. But almost nobody wanted to talk about the decade afterwards, between 1945 and 1956. This was when you had the short period of terror, violence and Polish Stalinism. To stay safe, people felt the need to just go along with what others were saying, or stay out of politics, or use communist jargon without necessarily believing it. I don’t judge them for it, and I wouldn’t describe all of those people as collaborators. It’s easy to feel moral certainty in retrospect, because we know that communism ended. But if you were living in 1949, it might not have been clear to you that communism was going to end. In very repressive societies, maybe about 10% of people who are really evil – collaborators, torturers. Maybe 10% of people are really brave and who find ways to resist. And then around 80% of people have kids, they have parents, they have to have jobs and they’ve had to get through it somehow. Strange though it may sound, I’ve found that the work I did on that book is now very useful in explaining some of what’s going on in the United States today. There are plenty of members of the Republican Party in Congress who know perfectly well that Donald Trump says many things that aren’t true. But they avoid criticizing him because it’s inconvenient, because they would get in trouble, because someone would attack them on the internet. So actually you don’t even need mass terror to get people to conform. JC: Is Gen Z reinventing agency? AA: We’ll see. In any generation you can find groups of people who want agency. If you live in a society that’s unfair, for example where a tiny number of people have captured most of the wealth, then at a certain point people rebel. This is always easier for younger people, who have you have less to lose. The question now is how the internet will affect the relationships between citizens and the state, and how it will change organizations. The “Twitter revolutions” people spoke about as early as 2008-9, mass protests organized online, have often proved to be very superficial. Although you can easily join something just by clicking, the work of creating a real movement requires physical participation. Successful mass movements of the past, for example the Civil Rights movement in the United States, were built by people who had spent many years together. They had participated in non-violent workshops together. They practiced and prepared. Just using the you can get everybody to show up at a certain moment, but then when the protest is broken up, nothing happens. It’s also true that the repressive regimes have more recently learned how to use the internet to undermine leaders and movements. Most of all, they now understand how to make people cynical. The form of propaganda that most modern authoritarians use - and I think the Russians really pioneered this - deploys sneering cynicism. Instead of praising the rulers, the regime propagandists mock the opposition movement leadership for being supposedly corrupt or sexually degenerate, with the goal of undermining any kind of idealism. JC: MAGA grew on the internet? AA: MAGA is a real grassroots movement. They had symbols, red hats, they showed up at rallies. But you’re right that the cynicism, the sarcasm and the distrust that the movement embodies came originally from the internet, and this is different. Fifty years ago, most European political parties had a social base in real organizations, in trade unions for Social Democrats, in church groups for Christian Democrats. As people stopped going to church and as the trade unions became smaller, the social base of these parties disappeared. Now people who wouldn’t have known one another in the past meet on the internet and create new movements, many of which don’t last. JC: Is history ending? Going in stale circles? AA: History never ends. In truth, human beings want contradictory things at the same time: order and freedom, stability and change. These things are never resolved, and when a society swings too far in one direction, people always push it the other way. But each time that happens, the result is different. Certainly it is true that we are now in a period when old philosophers and ideas from the 1930s are undergoing a revival. Carl Schmitt, who was a philosopher who was very influential on the Nazis, is back as an influence on both the far left and the far right, once again inspiring people to think that all politics has to be existential, that all politics is about defining and defeating enemies. In the US, some are also bringing back dominionism, the idea that we need a Christian and not a secular state. It’s also true that we are living through a more fundamental shift. The old left-right divide, which was mostly about the size of the state, is much less important now. Instead, we are arguing about more fundamental things: what are our rights, what protects our freedom. Or how much power do we want to give small elites, versus how much power to give ordinary people. In America a small group of very wealthy people now control information, because they control the social media platforms and AI, which means they determine what people will read and learn. Finding a way to preserve preserve zones of autonomy and independent thinking, this is going to be the main task for the next generation. JC: What is the one book that a person interested in Central Europe should read? AA: You could read my book “Iron Curtain: the Crushing of Eastern Europe” which tells the story of how the Soviet Union imposed its culture on the region. Or read Tim Snyder’s history of the region, “The Reconstruction of Nations: Poland, Ukraine, Lithuania, Belarus 1569-1999.” And everyone should read “The Captive Mind” by Czesław Miłosz, which describes exactly the phenomenon we were talking about: why do people collaborate? I joined Scott Galloway and the brilliant Fiona Hill in a discussion about the wars in Ukraine and Iran, the future of global power, and what these conflicts reveal about America's role in the world. Scott told us that this was the 400th edition of his podcast, which is quite a number: My friend Francesco Chiamulera runs a brilliant series of literary events, Una Colline di Libri, A Hill of Books, in the Prosecco Hills, a region of vineyards and elegant hill towns in the Veneto, north of Venice. We did an event in Vittorio Veneto and also drove and biked around the countryside. Buy Autocracy Inc Buy Iron Curtain Open Letters, from Anne Applebaum is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe

Jun 13 • 4:15 AM EDT • Politics • anneapplebaum.substack.com

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By reconnecting food, culture and health, it offers a practical pathway to prevention. Brazil: community therapy as a public health tool Brazil’s experience centred on Integrative Community Therapy, a methodology developed over 40 years ago by Dr Adalberto Barreto and now used in more than 47 countries. Therapy circles create spaces where participants share experiences and coping strategies, building social support networks at very low cost. Within Brazil’s Unified Health System, the approach has expanded rapidly since its inclusion in national policy in 2017. By 2025, more than five million integrative practice procedures were delivered annually in primary care, with registrations for this therapy increasing by over 500% in eight years. The main challenge now is equity, with access still concentrated in urban areas such as São Paulo. A shared regional direction against a global backdrop Drawing these experiences together, Dr Natalia Aldana of the TCIM Network of the Americas highlighted the shared outcomes of the interventions discussed. Such approaches strengthen healthy behaviours, social networks and community resilience; they are low-cost, adaptable and enable active participation in care, while showing potential to reduce the burden of noncommunicable diseases.The regional momentum mirrors a broader global shift. Dr João Paulo Souz, Director of BIREME (Latin American and Caribbean Center on Health Sciences Information), the specialized center of PAHO/WHO, emphasized that the Global Traditional Medicine Strategy 2025–2034 promotes a vision centred on people, evidence and integrated use. He noted that health should be understood through the relationships between people, community, nature and spirituality. Self-care interventions as a critical pathway towards universal health coverage Dr Manjulaa Narasimhan, Unit Head for Sexual Health and Well-being across the Life-course at WHO, delivered a presentation titled Advancing Self-Care in Traditional Medicine: Aligning the WHO Traditional Medicine Strategy 2025–2034 with the WHO Self-Care Framework, co-authored by Dr Geetha Krishnan Gopalakrishna Pillai, Unit Head for Research, Data and Innovation at the WHO Global Traditional Medicine Centre. WHO recommends self-care interventions for every country and economic setting as a critical path to reach universal health coverage – and traditional medicine acts as a bridge for self-care. Dr Narasimhan explained that traditional medicine contributes most effectively to self-care when embedded directly into primary health care, not operating in parallel, siloed systems. This, she stated, “is possibly the only sustainable way to deliver continuity of care that meets the needs, rights and priorities of communities and individuals”. The Global Traditional Medicine Strategy 2025–2034 is a move towards a more people-centred approach to health care that champions holistic approaches to health equity and patient autonomy.The integration of traditional medicine and self-care requires collaboration across disciplines, clear referral pathways, trained health and care workers, and strong leadership that supports integration. The WHO self-care competency framework defines 10 key competencies for health and care workers to support self-care in their clinical practice, supported by the WHO guideline on self-care interventions for health and well-being. These documents help health-care workers safeguard their own well-being and ensure that care is consistent, safe and grounded in shared standards and values.Together, the discussion through this dialogue points to a fundamental shift in how health systems are designed in the region, and globally, towards models that are more inclusive, culturally-grounded and responsive to the needs of the communities they serve. It is a move towards a system where traditional medicine is respected and responsibly integrated, where self-care provides empowerment and evidence-based care, and where health systems are supportive rather than being distant from these systems.Traditional medicine perspectives from Bolivia, Mexico and Peru - WHO's "Restoring Balance" seriesInnovative Experiences to Strengthen Health and Self-Care through Traditional, Complementary, and Integrative Medicine was streamed in Spanish, with Spanish and Portuguese subtitles. Recordings are available through the CABSIN YouTube channel with Portuguese subtitles and on the BVS MTCI Americas YouTube channel with Spanish subtitles. Dr Narasimhan’s session can be watched in English on both channels.

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May 16 • 1:32 PM EDT • Health • aljazeera.com

Indiana Jones and the Great Circle Nintendo Switch 2 tech analysis, including frame rate and resolution

Digital Foundry has provided its technical analysis of Indiana Jones and the Great Circle on Nintendo Switch 2, which goes over the game’s frame rate, resolution, and more in detail. Overall, MachineGames has produced what looks to be a solid port. The game even retains ray tracing and other graphical features present in other versions. Here’s the full roundup of...

May 13 • 1:22 PM EDT • Technology • nintendoeverything.com

Review: Indiana Jones and The Great Circle Arrives Surprisingly Intact on Switch 2

With image quality that eclipses Xbox Series S.

May 13 • 1:00 PM EDT • Technology • digitalfoundry.net

Hempfield, Conestoga Valley prepped and ready for L-L League volleyball championship showdown

There are only two undefeated teams in Lancaster-Lebanon League boys volleyball circles.

May 13 • 7:45 AM EDT • Sports • lancasteronline.com

Almost half of everything orbiting Earth is space junk

Abandoned rocket parts, dead satellites, and more circle the planet.

May 12 • 3:06 PM EDT • Science • popsci.com

Indiana Jones and the Great Circle's Nintendo Switch 2 port is finally here and it holds up pretty well

Bethesda and MachineGames' Nintendo Switch 2 port of Indiana Jones and the Great Circle is a looker with robust performance and a few neat tricks.

May 12 • 7:01 AM EDT • Technology • eurogamer.net

"My fear doesn't matter" - Troy Baker reflects on recreating the opening to Raiders of the Lost Ark as Indiana Jones and the Great Circle arrives on Switch 2

Troy Baker looks back on recreating the opening to 1981's Indiana Jones and the Raiders of the Lost Ark for the Great Circle's tutorial.

May 12 • 5:15 AM EDT • Technology • eurogamer.net

Lilac Festival continues with Art in the Park and Small Business Circle at Highland Park

The Lilac Festival continued for the second day at Highland Park.

May 9 • 6:14 PM EDT • Business • whec.com

My grandmother raised me. I cared for her at the end.

My grandmother was my stability growing up. As she aged, I became the one to care for her. It was a full circle bond.

May 9 • 10:45 AM EDT • Business • businessinsider.com

CAIR Releases Analysis of Anti-Muslim Oklahoma Politics

The Council on American-Islamic Relations (CAIR), the nation's largest Muslim civil rights and advocacy organization, today released a new analysis detailing a multi-front effort to push Oklahoma Muslims outside the circle of the state’s protected civic and religious life — through legislation, thro

May 8 • 11:36 AM EDT • Politics • cair.com

San Diego Padres sale a full-circle moment for Black baseball

The San Diego Padres' sale to Kwanza Jones and José E. Feliciano is a Black baseball milestone: the first Black-owned MLB team since the Negro Leagues.

May 7 • 3:17 PM EDT • Sports • andscape.com

William Blair Acquires Inner Circle Sports To Expand Sports, Media, And Entertainment Investment Banking Platform

William Blair announced it has entered into a definitive agreement to acquire Inner Circle Sports, a boutique investment bank focused on the global sports, media, and entertainment sectors. Financial terms of the transaction were not disclosed.

May 7 • 2:51 PM EDT • Entertainment • pulse2.com

Kalshi is losing Washington

Congress, the courts, the states, the leagues, and now the President's own circle have all landed in the same place at the same time: this isn't a market. It's a casino with a lobbyist.

May 7 • 9:10 AM EDT • Politics • floridapolitics.com

William Blair Buys Inner Circle Sports in Sports Dealmaking Push

William Blair is buying Inner Circle Sports, a move that will bolster the investment bank's presence in sports dealmaking and M&A transactions.

May 5 • 7:59 AM EDT • Sports • sportico.com

The Riverside-St. Frederick winner won a state title with standout pitching and a high-scoring lineup

SULPHUR — Still sore after she threw 135 pitches and struck out 14 in a semifinal, Kamryn Cancienne returned to the pitcher’s circle the next day feeling confident—not only in

May 3 • 7:11 PM EDT • Sports • nola.com

Mike Perry wants Jake Paul in an MMA fight

Former UFC fighter and Bare Knuckle Fighting Championship's "King of Violence" Mike Perry lost to Jake Paul in a boxing match in July 2024. "Platinum" wants a rematch but under mixed martial arts rules. "I think things come full circle all the time. I've continued to work hard before getting the ...

May 3 • 1:35 AM EDT • Sports • sports.yahoo.com

Indiana Jones and the Great Circle reveals Nintendo Switch 2 frame rate, resolution, and DLSS usage

Indiana Jones and the Great Circle Nintendo Switch 2 tech specs released, and the developer promises good things for this version.

May 1 • 9:42 AM EDT • Technology • nintendoeverything.com

Dupont Circle business struggle while navigating streetscape construction

A major streetscape project along Connecticut Avenue in D.C. is triggering a growing sense of urgency among small business owners in Dupont Circle, who said the

May 1 • 3:47 AM EDT • Business • wjla.com

Indiana Jones and the Great Circle gets first Nintendo Switch 2 gameplay

The first pure gameplay for the upcoming Nintendo Switch 2 version of Indiana Jones and the Great Circle is now available. A new 15-minute video has surfaced with the footage. It looks like the gameplay here is taken from an early portion of the title. Although we did get a trailer previously, this is our first extended, uninterrupted look at...

Apr 30 • 10:14 AM EDT • Technology • nintendoeverything.com

"It Is Just One-To-One" - MachineGames Talks Preserving 'Indiana Jones And The Great Circle' On Switch 2

"We haven't scaled back or cut content"

Apr 30 • 10:05 AM EDT • Technology • nintendolife.com

Dupont Circle businesses struggle amid construction

Some Dupont Circle businesses say they are struggling as construction on Connecticut Avenue reduces foot traffic. News4’s Jackie Bensen reports.

Apr 29 • 11:41 PM EDT • Business • nbcwashington.com

PayPal's new CEO makes Venmo a standalone business unit as potential buyers circle

PayPal is betting that a new corporate structure can reignite growth at a company that has lost ground to Apple, Google and Stripe in the e-commerce battle.

Apr 29 • 2:15 PM EDT • Business • cnbc.com

Why Treehub Is Investing In Science-First Founders Leading Healthcare Innovation

Treehub, the Stanford-adjacent residency program backed by the AI Health Fund, is focused on building the next generation of great healthcare founders born in labs, hospitals and academia instead of traditional startup circles.

Apr 29 • 9:45 AM EDT • Science • forbes.com

Why Treehub Is Investing In Science-First Founders Leading Healthcare Innovation

Treehub, the Stanford-adjacent residency program backed by the AI Health Fund, is focused on building the next generation of great healthcare founders born in labs, hospitals and academia instead of traditional startup circles.

Apr 29 • 9:45 AM EDT • Health • forbes.com

Dupont Circle small businesses seek financial help amid city construction project

Some business owners in Dupont Circle say a construction project aimed at improving the D.C. neighborhood is hurting sales.

Apr 28 • 4:32 PM EDT • Business • wtop.com

'Toy Story 5' faces tech age as a Pixar legend comes full circle (exclusive)

'Toy Story 5' faces the tech age more than 30 years after the first movie, while animation legend Andrew Stanton contemplates his final Pixar film.

Apr 28 • 12:00 PM EDT • Entertainment • ew.com

Dupont Circle business owners say nearby construction has been devastating

Apr 27 • 11:24 PM EDT • Business • wusa9.com

2026 Indy 500 Odds: Alex Palou Favored, Kyle Kirkwood Close Second

Alex Palou is the reigning Indy 500 champion, but can he get back into Winner's Circle at the Brickyard this season? Here are the latest odds.

Apr 27 • 1:00 PM EDT • Sports • foxsports.com

Google’s new gradient icon design is coming to more apps

So long to the boring “things in a circle” look.

Apr 26 • 2:34 PM EDT • Technology • theverge.com

CEOs in the PMO: Mark Carney’s Inner Circle Gives Business More Power in Ottawa

Also: What Kraken tells us about Canada’s defense sector

Apr 24 • 12:45 PM EDT • Business • bloomberg.com

Google Wallet rolling out big homepage, search redesign

Google Wallet is beginning to widely roll out a big redesign of the app on Android that upgrades the passes experience.

Apr 23 • 9:59 AM EDT • Technology • 9to5google.com

A grant kept this Indy venue alive. Now the federal government wants it back.

Black Circle received a piece of the Shuttered Venue Operators Grant during the pandemic. Now, the Small Business Administration wants it back.

Apr 23 • 5:20 AM EDT • Business • indystar.com

Four women accuse Eva Lopez Chavez, a SLC Council member, of unwanted ‘sexual’ advances

Four women from Utah political circles accuse Eva Lopez Chavez, a Salt Lake City Council member and Democratic congressional candidate, of what they consider unwanted sexual advances.

Apr 22 • 9:25 PM EDT • Politics • sltrib.com

Business contest ends in sweet smell of success for SCH students

Two Springside Chestnut Hill Academy students were among the top winners recently in a pitch competition to identify new business ideas from high school entrepreneurs.

Apr 22 • 8:00 PM EDT • Business • chestnuthilllocal.com

Demonstrators Circle Science Center Plaza in Largest Showing Yet | News

Demonstrators Circle Science Center Plaza in Largest Showing Yet | News | The Harvard Crimson

Apr 21 • 7:19 PM EDT • Science • thecrimson.com

Google Wallet adds Live Update for flight tracking

As previously teased, Google Wallet for Android now offers Live Updates for tracking your current flight. If you add...

Apr 21 • 4:55 PM EDT • Technology • 9to5google.com

When former friends conclude we are the problem, we have a problem

April arrived in Colorado this year displaying the Janus-like dual visages that characterize MAGA America. The ecstatic, giddy enthusiasm of the Artemis crew which just circled the moon before returning to a near perfect splashdown off San Diego reminded each of us why we are so proud of our country — its daring, its commitment […]

Apr 20 • 2:45 AM EDT • Politics • coloradopolitics.com

Student filmmakers shine at Aquila’s Full Circle Film Fest

Media production company Aquila Entertainment showcased a variety of student-made shorts at their latest annual Full Circle Film Fest on April 14.

Apr 18 • 9:00 AM EDT • Entertainment • fsunews.com

A Hahnville freshman 'battled in the circle' to pitch a complete game in her first playoff action

The moment wasn't too big for this Hahnville freshman in her first varsity playoff game.

Apr 17 • 9:30 PM EDT • Sports • nola.com

Proclamation Brings Awareness To State’s Behavioral Health Workforce Needs  - West Virginia Public Broadcasting

Recognition from Gov. Patrick Morrisey is helping autism treatment advocates to expand resources in West Virginia.

Apr 17 • 5:07 PM EDT • Health • wvpublic.org

Students compete in statewide health competition at Mercy College of Ohio

Janice Servick, dean of nursing at Mercy College of Ohio, had a full circle moment at the college Thursday. She stood before dozens of students, young ...

Apr 16 • 1:16 PM EDT • Health • toledoblade.com

College of Science announces 2026 Galileo Circle Awards

The awards honor some of the college’s most exceptional faculty and staff, recognizing excellence in teaching, research, mentoring, outreach and service.

Apr 16 • 8:00 AM EDT • Science • science.arizona.edu

Iran war has some Republicans worried their chances of keeping the House are slipping away

The White House had long circled Tax Day as the unofficial start to a critical midterm campaign meant to highlight how much money the administration was putting back in voters’ pockets.

Apr 16 • 4:00 AM EDT • Politics • cnn.com

California Science Center completes construction on new Air and Space Center - Beverly Press & Park Labrea News

As NASA’s Artemis II astronauts circled the moon and moviegoers flocked to theaters to see Ryan Gosling travel...

Apr 15 • 9:00 PM EDT • Science • beverlypress.com

'Show me the money'

What happens when a former senator, a prior governor, a previous representative, and a political advocate talk about corporate money in politics? The exact scenario played out at the MSU-hosted discussion titled “Money, Transparent Elections and the Montana Experience,” at the end of last week. Audience members experienced a bipartisan glimpse into corporate influence, how it is built, spent on campaigns and challenged by voters. A candid conversation emerged between guest speakers former Montana U.S. Senator Jon Tester, former Attorney General and Governor Marc Racicot, previous state senator and representative Jeff Mangan, and political advocate Michel Beckel. The conversation between the four guests circled back to Citizens United v. Federal Election Commission, a landmark 2010 Supreme Court ruling allowing corporations, unions, and associations to spend unlimited amounts of money influencing elections. The decision concluded independent political spending is a form of free speech protected by the First Amendment, directly leading to the rise of massive political action committees and ‘dark money’ in U.S. elections spending. Tester was the first to address the ‘black elephant’ in the room. Responses to moderator questions are edited for clarity and brevity. “We are seeing unbelievable sums of money being put out trying to influence people on how to vote,” Tester said. “Oftentimes the truth goes out the window before the campaigning even starts.”

Apr 15 • 7:00 PM EDT • Politics • bozemandailychronicle.com

Liverpool FC pays tribute on 37th anniversary of Hillsborough tragedy

On the 37th anniversary of the Hillsborough disaster, players, staff and club officials of Liverpool Football Club have been at Anfield to lay wreaths and pay tribute to the 97 fans who lost their lives. The club will observe a period of silence at 15:06 BST - the time at which Liverpool's FA Cup semi-final against Nottingham Forest was stopped. After the silence, 97 biodegradable balloons will be released from the centre circle at Anfield.

Apr 15 • 8:38 AM EDT • Sports • sports.yahoo.com

YouTube Music rolls out split-view Now Playing redesign on Android, iOS

The split view Now Playing redesign that YouTube Music has been working on since last year is now widely rolling out.

Apr 15 • 1:50 AM EDT • Technology • 9to5google.com

Bucks County Community’s Choice Awards business spotlight: Inner Circle Physical Therapy & Myofascial Release Center

The Bucks County Community's Choice Awards nominations are open now! It's time to recognize your favorite local businesses.

Apr 11 • 6:01 AM EDT • Business • phillyburbs.com

In praise of popular science

As a kid, I was enthusiastically and unreservedly in favor of a manned space program. Our destiny lay in the stars, I figured. Get people out there. We need Star Trek here and now. As I got older, I became rather disenchanted with the idea. Humans are expensive, fragile, and inefficient as space cargo. We could flood the solar system with 100 robotic probes for the price of any single manned mission and get back just as useful data. Besides, it turns out space travel is dangerous. Tusk is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe When it came to the recent Artemis II mission, my cynical side didn’t really see the point. Flying around the Moon and back is literally something we did before I was born, and I once owned a Members Only jacket. Apollo 8 circled the Moon ten times and returned to Earth safely the same month that “Chitty Chitty Bang Bang” was released. What was the point of repeating a feat that far braver people once did with tin foil and slide rules? Yet I’ve surprised myself with how moving I’ve found the Artemis II mission to be. The photos have been stunning. The crew has been professional and engaging. There have been modest but important milestones — the farthest humans have travelled from Earth; the first woman, person of color, and non-American to leave low-Earth orbit; innovations in communication, and more. One thing that really stood out is that this is really NASA at its finest. Not that this is the most important mission they ever pulled off, but they did this in a competent way that celebrated the achievements and kept the crew and the science at the forefront of the project. This wasn’t some billionaire throwing celebrities or cars into orbit as a vanity project — this was a collective effort to send experts in to do a job and come home safely. We don’t see that sort of thing much these days. I’m guessing few people would describe many government agencies as inspiring, but this one counts for me. We’re living through a profoundly anti-science era, in which pathbreaking, lifesaving discoveries like mRNA vaccines are routinely downplayed or even vilified. As I’ve noted previously, this era is something like that of the Red Scare in the 1940s and 50s, in which “egghead” professors were portrayed as out of touch or even hostile to regular Americans. One of the things that helped break that spell was Sputnik — the Soviet communications satellite that demonstrated that the United States was falling behind in crucial scientific research and applications. Its launch triggered a new appreciation for American science and goaded the federal government into supporting research universities and labs. I’m not saying that Artemis is the equivalent of Sputnik, but it potentially reminds people that there’s some value to scientific endeavors and the human faces attached to them. Despite my love for the show “For All Mankind,” I’m far from convinced that there’s any real value to putting colonies on the Moon or Mars that would justify the capital investment and the massive health risks to the astronauts. But sending scientific good will ambassadors on a trip into space once in a while? Bring it. Share

Apr 10 • 9:54 PM EDT • Science • smotus.substack.com

Letters to the Editor: Anyone with political aspirations should be fighting to stop Trump

'Everyone knows President Trump is out of control, and yet Congress and the Supreme Court sit back and watch as we circle the drain,' writes an L.A. Times reader.

Apr 10 • 10:00 AM EDT • Politics • latimes.com

A tiny experiment using Artemis II astronaut cells could reshape medicine

Chips seeded with the astronauts’ bone marrow cells circled the moon to help probe how deep-space flight affects human biology.

Apr 9 • 6:00 AM EDT • Science • washingtonpost.com

Twin powers activate: Kullar brothers helping Ephrata challenge in L-L League boys volleyball

Don’t look now, but Ephrata is kicking up a fuss in Lancaster-Lebanon League Section 1 boys volleyball circles.

Apr 9 • 5:00 AM EDT • Sports • lancasteronline.com

YouTube Shorts will use AI to make avatars that look and sound like you

YouTube is now letting users create an AI avatar that looks and sounds likes them for use in Shorts. The feature...

Apr 8 • 5:39 PM EDT • Technology • 9to5google.com

NYT report details divisions inside Trump’s inner circle as the president weighed striking Iran

Apr 8 • 1:23 PM EDT • Politics • cnn.com

Michigan football's new 'circle of trust' for wide receivers

Michigan football's new offensive coordinator Jason Beck is implementing a 'circle of trust' for players to earn playing time.

Apr 6 • 3:48 PM EDT • Sports • sports.yahoo.com

Chiefs make 'aggressive' 2026 scheduling request with NFL: Kansas City pushing hard to play in these two games

The Chiefs have circles two dates on the 2026 schedule that they definitely want to play in

Apr 6 • 1:42 PM EDT • Sports • cbssports.com

Shared Success

Across Indiana, a growing number of company leaders are exploring employee ownership as a long-term business strategy. While employee ownership succession planning has been implemented across all …

Apr 4 • 8:00 PM EDT • Business • buildingindiana.com

UCLA brings energy to first spring practice of 2026

From the players doing jumping jacks and chanting in rhythm with the exercise, to the hollering when the team circled up at midfield, the energy traveled well beyond Spaulding Field.

Apr 2 • 4:52 PM EDT • Sports • sports.yahoo.com

SoFi Launches Big Business Banking to Power Fiat and Crypto Banking on a Single Regulated Platform

SoFi Technologies, Inc. (NASDAQ: SOFI), the one-stop shop for digital financial services, today announced the launch of SoFi Big Business Banking, a new offe...

Apr 2 • 8:00 AM EDT • Business • businesswire.com

'Spectacular!': BBC science editor reacts to Artemis II launch

Nasa's Artemis II has blasted off and is now orbiting Earth, before continuing on to circle the Moon.

Apr 2 • 4:40 AM EDT • Science • bbc.co.uk

'Spectacular!': BBC science editor reacts to Artemis II launch

Nasa's Artemis II has blasted off and is now orbiting Earth, before continuing on to circle the Moon.

Apr 2 • 4:40 AM EDT • Science • bbc.com

Williamston’s ‘Bad Books’ gives nuance to polarizing politics

As artistic director and co-founder of Williamston Theatre, Tony Caselli knows how it feels when material is met by backlash from the community. When Williamston put on an updated version of “Dial …

Mar 31 • 8:00 PM EDT • Politics • lansingcitypulse.com

TJC science center director details upcoming Artemis II launch to the moon

NASA is preparing to launch Artemis II, a manned flight on course to circle the moon and going further out than humans have ever gone.

Mar 31 • 4:23 PM EDT • Science • kltv.com

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

Navigating the social media minefield

Scientists and researchers seeking to announce promising findings, exchange ideas or contribute to policy discussions outside of academic circles may find social media an expedient tool.But increasingly, scientists and other professionals are discovering that online platforms can be a double-edged sword: while sharing their work and expertise is crucial for visibility and meeting funder expectations, it also exposes them to baseless criticism and even accusations of spreading false information."It is getting harder and harder for scientists, and researchers in general, to convey their findings without facing attacks on their legitimacy and accuracy of their research," says Valère Ndior, a professor of public law at the University of Western Brittany in Brest, France, who has spent more than a decade studying misinformation on social media. Researchers attempting to challenge deceptive online information may themselves be accused of political bias or not being objective in their research, he explains, adding that some scientists disengage because they feel overwhelmed and unable to sustain meaningful dialogue. "It is quite sad to see in some instances that researchers end up leaving social media altogether because they feel like the pressure is getting too intense or feel threatened," he says.Ndior, a past president of the Francophone Network of International Law, is also involved in European efforts to make science and research findings more accessible to the public. As an ambassador for the Science Comes to Town (SCTT) project, he has participated in recent discussions on public perceptions of science and online misinformation. The European Commission-funded initiative connects Brest and two other cities — Kiel in Germany and Split in Croatia — and aims to strengthen ties between communities, universities and research institutions to promote science awareness and cooperation across Europe.Coordinated campaigns around contentious topicsNdior draws a clear distinction between critical thinking and thoughtless criticism. Yet he sees online discussions being increasingly shaped by suspicious behaviour and coordinated information campaigns — including "raids" aimed at dominating discussions and "astroturfing," where small groups act as larger movements to sway debates. Tracking these patterns has become harder because some platforms have restricted data or charge for it, despite provisions of the European Union's Digital Securities Act aimed at ensuring researchers can have access to such data. According to Ndior, "platforms became more reluctant from the moment access to data became a legal requirement rather than a voluntary initiative."Unfounded claims and scepticism about science existed long before Internet chat groups. But the noticeable rise in online hostility has intensified around contentious topics, such as the coronavirus pandemic and climate change, alongside the weakening of gatekeepers to moderate content.For Ndior, dubious claims about pandemic countermeasures and vaccine safety highlighted the struggle between "balancing freedom of expression and the protection of public health and order." Efforts to remove social media content deemed false or risky for public health triggered accusations of censorship and the silencing of legitimate discussion, and in some cases, legal challenges.Concerns about attacks on the credibility of scientists and researchers have generated a flurry of academic papers in recent years and prompted professional communities to address ways to counter online attacks. Such unease extends to the generation that has grown up with digital media. Ndior points out that his students, some of whom research artificial intelligence regulation, hate speech, online surveillance and other controversial topics, hesitate to share their work or viewpoints online. "Many of them don't want to expose themselves too much because they don't feel ready to be faced with the backlash of other people criticising their research," he explains.Safer harbours for engagementLegal challenges against false or defamatory posts are not necessarily a solution — especially given the trans-jurisdictional nature of the Internet. Lawsuits also take time and money, and if they fail, can be counterproductive. Instead, Ndior advises scientists and researchers to be selective in how and where they communicate. Professional online platforms and moderated discussion spaces offer a better environment for engagement. He also highlights the value of more traditional formats, such as radio interviews and in-person discussions at schools, libraries and science fairs, which encourage dialogue with the public. "Personal contact makes a big difference," he says, while acknowledging that these approaches lack the global reach of social media.Ndior’s interest in digital law and online misinformation stems from his time as a doctoral student in international law in the early days of social media. He began analysing posts from governments and heads of state to determine if they could be considered official and thus used as evidence in litigation. His work attracted media attention and led to conference and speaking invitations. "This was not part of my plan," he says, "but this is what happens as a researcher — your interest is sparked by a certain event or phenomenon, and it suddenly becomes your focus."Ndior believes SCTT provides "a double benefit" for researchers, enabling them to connect with peers and interact with the public. "There is a wide community of people who are not in academia who are critical thinkers looking for opportunities to ask questions, to get information and contribute their ideas,” he says. "I really value that kind of feedback."Science|Business, which connects policymakers, academics and industry through its news reporting, analysis and events, is an SCTT partner.

Mar 29 • 8:00 PM EDT • Science • sciencebusiness.net

Three Berkeley Lab Researchers Named AAAS Fellows

Three scientists, Blake Simmons, Abby Dernburg, and Felix Fischer, have been elected into the 2025 class of AAAS.

Mar 27 • 3:50 PM EDT • Science • newscenter.lbl.gov

Composer of ‘Lion King’ chant sues comedian over ‘Circle of Life’ translation

The composer of the Lion King's 'Circle of Life' sues comedian after his botched lyrics translation goes viral

Mar 26 • 5:18 PM EDT • Entertainment • usatoday.com

Google says Android with Chrome is ‘fastest mobile platform for web browsing’

Google shared today that Android and Chrome have set “new performance records” for mobile web browsing in two benchmarks...

Mar 25 • 1:00 PM EDT • Technology • 9to5google.com

The debate over Trump’s mental health: ‘Malignant narcissist ’ or ‘superhuman president’?

While some warn of the danger of having someone suffering from ‘cognitive decline’ in the White House, his inner circle attributes his outbursts to his iconoclastic personality

Mar 23 • 7:46 AM EDT • Health • english.elpais.com

Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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