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President Trump Remarks to U.S. Embassy Personnel & Business Leaders in Ireland
President Trump delivers remarks to U.S. embassy personnel and business leaders in Ireland.
Widow breaks tradition of keeping politics out of 9/11 remembrances
Terry Strada, a widow of a 9/11 victim, broke the long-standing tradition of keeping politics out of Sept. 11 remembrances and called on President Donald Trump and Vice President JD Vance to hold Saudi Arabia accountable for the attacks.
Silverdale man experiencing mental health crisis taken into custody, found with multiple guns
The 24-year-old had multiple pistols in the bedroom with him.
New moment of silence held for those lost to 9/11 health effects
A moment of silence was held near ground zero in honor of those who have been impacted by the health-related effects of the aftermath of the 9/11 terror attacks in New York.
Vance’s midterm pitch is strikingly different from Trump’s
Vice President JD Vance offered a more realistic and nuanced midterm pitch, which was a striking contrast to President Donald Trump’s all-is-great, we’re-in-the-Golden-Age approach.
Former employee convicted of embezzling thousands from Cedar Rapids business
A man has been found guilty this week of stealing hundreds of thousands from his former employer.
Dan McGrath: At least the Bears have a football team to talk about
As the season opens, the good news is the Bears have the look of a legitimate playoff contender. Just don't ask about the stadium problem.
7 Takeaways From the Republican Midterm Convention
On the second night of the Republican gathering in Dallas, Vice President JD Vance was the headliner. But President Trump returned to center stage.
JD Vance pitches himself as Trump’s political heir on day two of Republican midterm convention
Vice-president dog-whistled, exaggerated claims of success and echoed Trump talking points to excited audience
Fact check: Trump, RFK Jr. and others make false claims on night 2 of GOP convention
(CNN) — President Donald Trump delivered another rapid-fire series of false claims on the second night of Republicans’ midterm convention on Thursday. Health Secretary Robert F. Kennedy Jr. did his own barrage of wrongness. And various other speakers uttered statements that were untrue, misleading or missing critical context.Here is a fact check of some of the assertions from the final day of the convention. This is not intended as a comprehensive list of Thursday’s falsehoods.Trump’s many false claimsTrump made numerous false claims, some of which he also made in his longer speech Wednesday.Trump claimed that there were “no empty seats” in the Dallas arena as he spoke Thursday, which was visibly untrue. CNN White House correspondent Alayna Treene, who was there, wrote in a live chat right after Trump made the claim that “I’m looking at rows of empty seats” and that “the idea that there are ‘no empty seats’ is just laughably untrue,” though she also said the room was mostly full. Trump has for years made false claims about supposedly never having had an empty seat.Trump further inflated one of his favorite fictional figures, claiming Thursday that “$22 trillion” in investment has come into the US; on Wednesday, he had put it at “over $20 trillion,” and even that lower figure has no apparent basis in reality. As of the time he spoke Thursday, the White House’s own website claimed there had been “$11.2 trillion” in “major investment announcements” this term, not “over $20 trillion,” and the White House figure was itself a major exaggeration of actual investment.Trump, talking about elections, lied that “there’s never been bigger cheaters” than Democrats; there is no basis for broadly describing Democrats as election cheaters. For the second straight night, Trump falsely claimed that the Biden administration allowed “25 million people” to pour into the country, though that number is nowhere close to correct. Trump again falsely claimed that former President Joe Biden and other Democrats “created the worst inflation in American history,” though even peak Biden-era inflation, 9.1% in June 2022, was far from the all-time record of 23.7%; it was a 40-year high, but the rate then fell sharply before Trump returned to office.Trump also baselessly claimed that Democrats would “defund the police” and give “voting rights and welfare to 25 million illegal aliens” if they won the midterms. Republicans will still control the White House in 2027 and 2028 and the president would be in position to veto any such changes if a Democratic-controlled Congress sought to make them, but there is no indication that Democrats want to do so. Also, even groups favoring strict immigration policies estimate that the total undocumented population is far less than “25 million” or even 20 million.As he did Wednesday, Trump claimed the US now has the world’s lowest prescription drug prices. The assertion is so broad that it is unclear what exactly Trump is referencing. But experts told CNN they highly doubt that the prices for brand-name drugs in the US are generally less than they are in other countries, and the Trump administration has not provided details to prove the claim.“It’s tough to claim that you’re getting the lowest prices anywhere in the world and then also not have any evidence to support that,” said Andrew Mulcahy, a senior health economist at RAND, while Diederik Stadig, senior healthcare economist at financial institution ING, said, “To say that the US now has the lowest drug prices in the world is at this moment not true.”And as he did Wednesday, Trump said “more Americans are working today than ever before” – which is true but nearly meaningless, since the number of people working in the US generally rises over time simply because the population rises over time.“There are more Americans working because there are more Americans. That’s the entire analysis,” Justin Wolfers, a University of Michigan professor of public policy and economics, wrote in his newsletter in August.RFK Jr.’s false claims on the pandemic, Trump’s record and moreFalse claim about Democrats and the 2024 electionKennedy unsuccessfully ran for the 2024 Democratic presidential nomination before withdrawing to run as an independent and then eventually endorsing Republican candidate Donald Trump. In Kennedy’s Thursday convention speech, he complained of how the Democrats handled the nomination race.At one point, he said, “For the first time in history, they cancelled their own convention. No voter ever cast a primary ballot for Kamala Harris, no elected delegate was ever consulted; the party of ‘No Kings’ simply anointed a queen.”Kennedy is entitled to express unhappiness about how quickly Democratic leaders coalesced around then-Vice President Harris after Biden unexpectedly dropped out of the race in July 2024, after the primaries were over and less than four months from Election Day. But it’s not true that the party canceled its convention or that delegates didn’t get any say.The convention was held; it was a four-day event in Chicago in August 2024. Democratic convention delegates officially nominated Harris in a virtual roll call vote in advance of the convention. It’s true that Harris was the only candidate on the roll call ballot, but that’s because she was the only candidate who gathered enough delegate signatures to appear on the ballot.It’s clear that party elites’ backing of Harris played a key role in the unusual nomination process. But Kennedy’s specific allegations that the convention was abandoned and delegates were cut out of the process are not true.False claim that Democrats closed ‘every church’ during the Covid-19 pandemicWhile attacking Democrats, Kennedy claimed that, during the Covid-19 pandemic, “They closed every church in our country for a year.”It’s not true that every church in the country was closed for a year, nor even that every church in a Democratic state was closed for a year.Every state issued some type of guidance or order about social distancing during the Covid-19 pandemic, but many states – including some led by Democrats and some led by Republicans – incorporated religious exemptions into those limitations on social interactions.According to a Pew Research Center analysis from April 2020, 15 states allowed religious gatherings to continue without a limit on their size. That set of states included Colorado, Michigan and Pennsylvania, which all had Democratic governors. And at least two states with Republican governors, Alaska and Idaho, were among the states that prohibited religious gatherings at least briefly.False claim that Trump ‘ended nine wars’Trump has repeatedly claimed that he has ended “eight wars.” Kennedy went one higher on Thursday, declaring, “President Trump has ended nine wars.”That’s false. Trump hasn’t even ended eight wars.Trump’s list of eight includes two situations that were never actually wars during his tenure: a diplomatic dispute between Egypt and Ethiopia and a mysterious supposed situation between Serbia and Kosovo. The list also includes a war, involving Rwanda and the Democratic Republic of Congo, that hasn’t actually ended despite a peace agreement brokered by the Trump administration.In addition, the list includes the war between Israel and Hamas, but Israel continues to conduct frequent attacks in Gaza despite a US-brokered ceasefire agreement. And it includes the brief 2025 conflict between Israel and Iran, though Israel proceeded to join the US in starting another war against Iran in 2026.Claim about reversing a decline in longevityKennedy speaking of the Trump administration, claimed Thursday: “We have now reversed a 30-year decline in longevity. “Kennedy referenced preliminary data that he said he had received from the US Centers for Disease Control and Prevention this week, but it’s unclear what metric of longevity he’s referring to.CDC data shows that US life expectancy had been steadily increasing for decades before a sharp drop during the Covid-19 pandemic. Life expectancy had already started to rebound in 2022, under the Biden administration, and reached a new record high in 2024 before Trump’s second term began.Preliminary data shared by the CDC in July suggests that life expectancy probably hit another record high in 2025.CNN has reached out to HHS for clarification on Kennedy’s comments.Claim that Democrats ‘lost 360,000 children’Speaking about Democrats, Kennedy said: “They somehow lost 360,000 children and they turned our federal government into the biggest child trafficking operation in world history.”Trump and other Republicans have made similar claims. But there’s no basis for the assertion that Democrats “lost” so many children or that the federal government was engaged in human trafficking.A 2024 report from the inspector general for the Department of Homeland Security said Immigration and Customs Enforcement had reported that more than 32,000 unaccompanied migrant children failed to appear as scheduled for immigration court hearings after being released or transferred out of custody between fiscal years 2019 and 2023 – a period that, notably, includes two years and four months under the first Trump administration. The report also said that 291,000 unaccompanied migrant children during this period were not given notices to appear in court.The report said that ICE had “no assurances” these children “are safe from trafficking, exploitation, or forced labor.” But it did not say all the children were actually “lost” and did not definitively assert that any of them were trafficked – let alone that the government was somehow involved in a trafficking operation. And, again, the report spanned parts of both a Republican administration and a Democratic administration.Aaron Reichlin-Melnick, senior fellow at the American Immigration Council, told CNN in 2024: “Long story short, no, there are not 320,000 kids missing. 32,000 kids missed court. That doesn’t mean they’re missing, it means they missed court (either because their sponsor didn’t bring them or they are teenagers who didn’t want to show up). The remaining 291,000 cases mentioned by the (Office of the Inspector General) are cases where ICE hasn’t filed the paperwork to start their immigration court cases.”Vance on inflation, crime and taxes on Social SecurityA false claim about the media and Biden-era inflationVice President JD Vance mocked the media during part of his speech on Thursday. But he made a false claim about Biden-era inflation while lampooning how the media supposedly challenged him over another false claim on that subject.Vance said: “The president and I would go during a campaign, we’d say, ‘You know, inflation is as high as it’s been in 100 years,’ and the fake news would say, ‘No, no, no, it’s as high as it’s been in 68 years.’ That ain’t good, ladies and gentlemen.”Mainstream journalists, at least, wouldn’t say that inflation under Biden was as high as it had been “in 68 years.” Rather, CNN and others noted that peak inflation under the Biden administration, 9.1% in June 2022, was the highest in about 40 years.Vance is entitled to make his general point that this correction still doesn’t make Biden-era inflation sound good, but his specific number was, again, wrong. And he didn’t acknowledge that inflation fell sharply under Biden after hitting the 40-year high, declining to 2.9% in Biden’s last full month in office, December 2024, and 3.0% in January 2025, when Trump and Vance were inaugurated.The rate was 3.4% in July 2026, the most recent month for which data is available.Trump didn’t end taxes on Social SecurityVance claimed, “We’ve ended taxes on Social Security.” Several other convention speakers, including Rep. Lisa McClain of Michigan, Rep. Ryan Mackenzie of Pennsylvania and Ohio House candidate Derek Merrin, similarly said the administration has achieved “no tax on Social Security.”It hasn’t. The big domestic policy bill Trump signed in 2025 did create an additional, temporary $6,000-per-year tax deduction for individuals age 65 and older (which phases out for individuals earning $75,000 per year or more), but as the White House has implicitly acknowledged, millions of Social Security recipients will continue to pay taxes on their benefits even before the temporary new deduction expires after 2028.The Social Security Administration said in 2025 that “the bill ensures that nearly 90% of Social Security beneficiaries will no longer pay federal income taxes on their benefits.Claim about violent crime rate under BidenWhile criticizing the Biden administration, Vice President JD Vance claimed Thursday that the US “became a country where violent crime exploded, unless, of course, you could afford private security.”But violent crime did not explode under Biden. In fact, as FactCheck.org reported last month, data collected and published by the FBI shows that the national violent crime rate was at a lower level in 2023 and 2024, the last two full calendar years of Biden’s term, than it was in 2020, the last full calendar year of Trump’s first term. The year 2020 was highly unusual in many ways – violent crime jumped amid the Covid-19 pandemic – but Biden nonetheless left office with violent crime lower than it was when he took over. In fact, the 2024 violent crime rate was even lower than the 2019 rate under Trump before the pandemic.There was an increase in violent crime during the earlier part of Biden’s term. But given the subsequent decline, it’s misleading at best to claim violent crime “exploded” with no further context.Asked earlier this month about Trump’s similar previous claims to have reversed a Biden-era upswing in violence, crime data expert Jeff Asher said in an email: “No, crime began dropping significantly in 2023 during the Biden administration. Murder fell at record rates in 2023, 2024 and 2025 and, while 2026 may not feature a record decline nationally, it is still on track to see a sizable double-digit decline this year. Violent crime similarly fell nationally in 2023 and 2024, though the drops were more muted than the decline that was recorded by the FBI in 2025.”Other GOP speakersMike Johnson’s false claim about the inflation Republicans inherited from BidenSome other speakers at the convention took aim at inflation under Biden. House Speaker Mike Johnson claimed that “Republicans inherited from the Biden administration record-high inflation.”That’s not true. The inflation rate was 2.9% in Biden’s last full month in office, December 2024, and 3.0% in January 2025, when Trump took over. That’s lower than the most recent rate, 3.4% in July 2026, and nowhere close to the all-time record of 23.7%, which was reached in 1920, or the highest point of Jimmy Carter’s presidency, 14.8%, which was reached in 1980.Johnson correctly said moments later that inflation reached “a 40-year high of 9.1% inflation” under Biden. But a 40-year high is not an all-time record. More importantly, Johnson didn’t explain that 9.1% was much higher than the rate Trump inherited or that the 9.1% rate occurred in June 2022, with roughly two-and-a-half years left in Biden’s term.The cumulative increase in prices from the beginning of the Biden administration to the end was also not the highest in US history. Federal figures show that beginning-to-end inflation under Biden was less than half of that during Carter’s term.What Johnson left out of his claim about a congressional resolutionWhile attacking Democrats as extreme, Johnson said: “Just last week, nearly every Democrat in the House of Representatives voted against condemning socialism and Marxism. They voted against it.”But the resolution didn’t use the word “Marxism.” And Johnson didn’t mention that the resolution wasn’t only about condemning socialism. Rather, it contained other language that Democratic leadership said was the focus of the party’s opposition to the resolution.The resolution’s first provision said it “condemns and denounces socialism in all its forms, including the Democratic Socialists of America, and opposes the implementation of socialist policies in the United States.” But its fifth provision said it “calls for enactment of the SAVE America Act,” Trump’s favored elections bill, which contains various provisions opposed by many Democrats.So while it’s very possible many Democrats would have opposed the resolution even without its expression of support for the SAVE America Act, the call to pass this elections bill served as a poison pill that ensured most Democrats wouldn’t support it.“House Resolution 1490 explicitly calls for enactment of the so-called SAVE America Act, which is the top legislative priority of far-right extremists,” Democratic House leader Hakeem Jeffries said in a statement last week.A New Mexico candidate left out key context in an attack on his opponentGreg Cunningham, a Republican House candidate in New Mexico, used some of his Thursday speech to criticize his Democratic opponent, Rep. Gabe Vasquez. Cunningham said of Vasquez: “He even voted against a resolution honoring the sacrifices and service of the brave men and women in law enforcement who protect, every day, our communities.”But Cunningham left out important context about the resolution. While its focus was expressing support for law enforcement, its preamble contained statements praising the Trump administration and criticizing “leftist activists,” “progressive politicians” and “sanctuary city policies” for allegedly making law enforcement less safe.In other words, a House member might vote against such a resolution, as the vast majority of Democrats did, because they disagreed with conservative components of it, not the general expressions of support for law enforcement. (CNN has reached out to Vasquez’s campaign and House office for comment on his vote.) It’s common for parties to write resolutions in a way that would make it difficult for opponents to support but would open those opponents to campaign attacks if they voted “no.”An Ohio candidate’s misleading attack about Democrats and votingMerrin, the Republican candidate running against Democratic Rep. Marcy Kaptur for a House seat in Ohio, claimed in his speech, “While Democrats talk about letting illegal immigrants vote in our election, Republicans fight for proof of citizenship, photo ID and fair elections.”It’s a big country, so it’s possible some Democrat somewhere is talking about letting undocumented people vote in some election. But Merrin’s claim is misleading at best. There is no proposal from Democrats in Congress to let undocumented people vote in the 2026 midterms – the election Merrin appeared to be referring to when he said “our election” – or vote in future federal elections.CNN has reached out to Merrin’s campaign for an explanation of his claim.House Majority Leader Steve Scalise invoked a similar theme in his speech Wednesday, claiming that Democrats had voted last week “to allow illegals to vote in our federal elections.” But there was no congressional vote on letting undocumented immigrants vote in any elections.Rather, there was a vote on the non-binding Republican resolution that included multiple provisions, including one that “reiterates the notion that American elections are for American citizens only,” one supporting Trump’s favored elections bill and one denouncing socialism.Opposing that multi-clause resolution doesn’t necessarily mean someone supports voting by any non-citizens, let alone non-citizens in the country illegally.This article has been updated with additional items.CNN’s Deja Oliver contributed to this report.The-CNN-Wire™ & © 2026 Cable News Network, Inc., a Warner Bros. Discovery Company. All rights reserved.
Republican midterm convention provides Vance center stage moment
The vice president has a primetime speaking slot just ahead of Trump on Thursday night
Behind the Scenes, Vance Gathered Unvarnished Views of the Iran War
Vice President JD Vance received sobering assessments about the war that did not line up with what he, along with President Trump and other top administration officials, were saying publicly.
Live fact check: Night 2 of the Republican Midterm Convention
Vice President JD Vance will speak Thursday at the Republican Midterm Convention in Dallas.
Multi-generational business expertise: How legacies in local businesses find sustained success
Join us Sept. 29 for our third Power Breakfast of 2026 as business leaders share how they leverage decades of institutional wisdom. The Greater Fayetteville Business Journal invites you to join us for our third quarterly Power Breakfast, The Family Business Advantage: How Third-Generation Leaders Drive Longevity and Innovation, where business owners, executives and community leaders will come together to explore how multi-generational leadership creates lasting success. We are proud to welcome CEO of Holmes Security Systems, Stephen Wheeler; Director of Communications for Copiers Plus, Drew Smith; Inside Sales at Hubbard Supplyhouse, Mary Grace Hurley; and Managing Partner of Luigi’s Italian Chophouse & Bar, Nate Ernst, as our featured panelists. Representing the third generation of leadership within their family businesses, each brings a unique perspective on honoring decades of tradition while embracing new ideas, technologies and strategies that drive long-term growth. Together, with moderator Lauren Willets, Director of the Family Enterprise Center at UNC’s Kenan-Flagler Business School, they will share the challenges, opportunities and lessons learned from leading established organizations into the future.“Growing up in a family business gave me a unique perspective on what business can be. I saw the pride my grandfather and father took in knowing someone was a Copiers Plus customer, and the deep responsibility they felt to support our employees and the families who depended on the business. Seeing that sense of connection firsthand is what drew me to the business, and the legacy they built continues to drive me today. I’m excited to be part of the conversation about how family businesses can honor what previous generations built while continuing to grow and evolve for the future,” shared panelist Drew Smith. “We are so excited to welcome our panelists highlighting long-standing Fayetteville family businesses. This theme has certainly piqued the interest of the business community even beyond Fayetteville. I’m excited to pass the moderator baton over to Lauren Willets. With her background and expertise in the subject, she’s sure to unlock some great talking points and perspectives that will keep the conversation fresh and interesting to our guests. “We are so excited to welcome our panelists highlighting long-standing Fayetteville family businesses. This theme has certainly piqued the interest of the business community A third-generation family business is quite an impressive accomplishment, and we look forward to examining their secrets to a successful succession at this upcoming Power Breakfast!” shared Greater Fayetteville Business Journal Publisher Faith Hatton. Join us at the Cape Fear Botanical Garden for an inspiring morning of networking, thought-provoking discussion and actionable insights into the power of continuity, strategic evolution and visionary leadership. Whether your organization is family-owned or simply focused on creating a lasting legacy, you’ll leave with ideas that can strengthen your business for generations to come.To learn about becoming a Power Breakfast sponsor, contact the Greater Fayetteville Business Journal at 910.240.9697 or marketing@bizfayetteville.com. Tickets are on sale now. Reserve your seat by going to fayettevillepowerbreakfast.com.
Vance calls on battleground state Republicans to ‘nationalize’ the midterms
The vice president made the remarks during a closed-door breakfast ahead of his speech Thursday at the GOP’s midterm convention in Dallas.
Amy Karnikian Recognized Among Business Aviation’s 2026 Top 40 Under 40
Los Angeles – September 10, 2026: The National Business Aviation Association (NBAA) has named Crowell & Moring’s Amy Karnikian to its 2026 Business Aviation Top 40 Under 40 list in the Business…
‘Marshals’ star defends Kayce moving on after wife’s shocking death: ‘Some time has passed’
Lilly’s GLP-1 Windfall to Fund Investments in Women’s Health
The pharmaceutical giant has been assembling experts and hunting for new medicines across conditions including bone health and endometriosis, sources told Bloomberg.
Oswego Players announce 2026 Don McCann contest winners
OSWEGO — “Undiscovered Country” has taken top honors in the Oswego Players 2026 Don J. McCann Memorial One-Act Play Writing Contest.By Dana Leslie Goldstein of Brooklyn, “Undiscovered Country” examines losing a loved one and how, through memories, lost love can be found. A panel of 15 volunteer judges praised it for its flow of dialog and richly developed characters. Goldstein receives a $250 cash prize. × This page requires Javascript. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. kAmv2C?6C:?8 2 S`d_ D64@?5\A=246 AC:K6 :D q6? sH@C t?@F89]” xE’D 2 DE@CJ @7 2 J@F?8 2FE:DE:4 >2? H9@ DECF88=6D E@ 4@?BF6C 9:D :??6C :?D64FC:E:6D 367@C6 2 3:8 2F5:E:@?]k^Am#placement_726068_0_i{width:100%;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid726068 = window.pid726068 || rnd;var plc726068 = window.plc726068 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=726068;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid726068+';place='+(plc726068++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');kAm%96 Sfd E9:C5\A=246 AC:K6 :D 2H2C565 E@ “p== 7@C 2 qF4
The Latest: Trump highlights his own record at midterm Republican convention
Republicans are gathering in Dallas for a unique two-day midterm convention, focusing on President Donald Trump. Trump plans to speak both nights and Vice President JD Vance will also address
The shrinking NSF support for the physical sciences
The agency has awarded fewer grants in the physical sciences this year than most years in its history.
iPhone Duo Gets Its Own Case and Folio With Kickstand
Apple today introduced two dedicated accessories for iPhone Duo, its Case and a Folio with Kickstand. The iPhone Duo Case is a thin, two-part design that wraps around both the front and back of the device. It uses built-in magnets that align with th iPhone Duo for what Apple calls a "magical attach experience". The case is made from polycarbonate with a matte coating and comes in Sand and Navy Blue.
Amy Joyce
Sheehan & Company welcomes Amy Joyce, CPA, JD, as Director of Private Client Services. Amy brings 25+ years advising high-net-worth individuals,
Bruce Lunsford, a 'bulldog' in Kentucky business and politics, dies
Bruce Lunsford had a lengthy list of accomplishments and experiences, from helping bring UPS to Louisville to running against Sen. Mitch McConnell.
Bruce Lunsford through the years: Our photos of Louisville businessman
Bruce Lunsford made plenty of headlines over the years in Louisville and around Kentucky. Check out photos from The Courier Journal's archives.
Analysis | How Canada, with elbows up, could hurt Trump in the midterms
The president's fight with our neighbor to the north — a constant over the course of his second term with a focus on trade — has turned ugly in recent weeks.
Ubisoft joins Xbox's disc-to-digital program, with more publishers to follow
Some outlets were highlighting Ubisoft's lack of involvement in Xbox's disc-to-digital program. Perhaps we should remind ourselves that it's still in Alpha testing.
Blackstone explores sale of ZO Skin Health, sources say
Investment firm Blackstone is looking to sell medical-grade skincare company ZO Skin Health, which could be valued at around $2 billion in any deal, according to people familiar with the matter.
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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3 Steps to Support Mental Health for Rural Youth
× This page requires Javascript. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. kAmWu62EFC6 x>A24EX *@F?8 A6@A=6 7246 2 8C@H:?8 ?F>36C @7 AC6DDFC6D[ :?4=F5:?8 24256>:4 6IA64E2E:@?D[ D@4:2= C6DA@?D:3:=:E:6D[ 4@>A=6I 72>:=J D:EF2E:@?D 2?5 F?46CE2:?EJ 23@FE E96:C @H? 7FEFC6D] |6?E2= 962=E9 DFAA@CE :D :>A@CE2?E 7@C 2== – 3FE :? >2?J CFC2= 2C62D[ E9@D6 AC6DDFC6D 2C6 6G6? 8C62E6C]k^Am kAmp44@C5:?8 E@ E96 r6?E6CD 7@C s:D62D6 r@?EC@= 2?5 !C6G6?E:@?[ E96 DF:4:56 C2E6 7@C CFC2= J@FE9 286D `d\`h :D fcT 9:896C E92? E96:C FC32? 4@F?E6CA2CED] q2CC:6CD =::E65 :?DFC2?46 4@G6C286[ F?C6=:23=6 :?E6C?6E 7@C E6=6962=E9[ D42C46 AC@G:56CD[ =@?8 5C:G6 E:>6D 2?5 =24< @7 AF3=:4 EC2?DA@CE2E:@? >26?E2= 962=E942C6 H96? :E’D ?66565] !=FD[ 2D2E:K2E:@?]k^AmkAm%92E’D H9J #FC2= |:?5D[ E96 @?=J ?@?AC@7:E 7@4FD65 @? >6?E2= 962=E9 7@C CFC2= 4@>>F?:E:6D[ 4C62E65 E96 #FC2= *@FE9 |6?E2= (6==?6DD A:=@E AC@8C2> DFAA@CE65 3J q@69C:?86C x?86=96:>] xE H2D 56G6=@A65 3J 2? 25G:D@CJ 4@>>:EE66 >256 FA @7 CFC2= J@FE9 E@ AC@G:56 E96:C A66CD H:E9 AC24E:42=[ 7C66[ 2446DD:3=6 >6?E2= 962=E9 C6D@FC46D] x?4@CA@C2E:?8 7665324< @? E96 A:=@E[ E96 FA52E65 AC@8C2> DA@?D@C65 3J E96 $@>A@ u@F?52E:@? :D ?@H =2F?49:?8 :ED ?2E:@?2= C@==@FE]k^AmkAm“p J@F?8 A6CD@?’D +x! 4@56 D9@F=5 ?6G6C 56E6C>:?6 H96E96C E96J 42? 2446DD >62?:?87F= >6?E2= 962=E9 DFAA@CE H96C6 2?5 H96? E96J ?665 :E[” D2:5 y6DD:42 {] $49=6:56C[ !9]s][ 5:C64E@C[ {23 7@C $42=23=6 |6?E2= w62=E9[ }@CE9H6DE6C? &?:G6CD:EJ] “~FC =23 :D E9C:==65 E@ A2CE?6C H:E9 #FC2= |:?5D 2D E96J 492>A:@? 6G:56?46\32D65[ 2?@?J>@FD[ 7C66=J 2G2:=23=6 DFAA@CE E@@=D 56D:8?65 E@ @G6C4@>6 32CC:6CD E@ 96=A\D666?E2= 962=E9 4C:D:D 27764ED J@F @C 2 =@G65 @?6[ 4@?D:56C E96D6 H2JD E@ 96=A]k^Amk9cmkDEC@?8mqC62< E96 $E:8>2 $FCC@F?5:?8 |6?E2= w62=E9k^DEC@?8mk^9cmkAmx? 4@>>F?:E:6D H96C6 D6=7\C6=:2?46 :D G2=F65[ 2D6E:>6D 36 G:6H65 2D 2 D:8? @7 H62>F?:EJ =6256CD 2?5 A66CD 42? H@C< E@ 492?86 E92E 4F=EFC6 3J ?@C>2=:K:?8 >6?E2= 962=E9 4@?G6CD2E:@?D] %9:D :?4=F56D 96=A:?8 E66?286CD 766= D66? 2?5 2446AE65 3J 65F42E:?8 E96> @? >6?E2= 962=E9 :DDF6D 2?5 4@A:?8 DEC2E68:6D[ =:DE6?:?8 E@ E96:C 6IA6C:6?46D H:E9@FE ;F58>6?E[ D92C:?8 J@FC @H? DE@C:6D 2?5 C6>:?5:?8 E96> :E’D 4@FC286@FD E@ D66< DFAA@CE]k^Amk9cmk:>8 DEJ=6lQH:5E9i d__AIj A255:?8\3@EE@>i `_AIj A255:?8\=67Ei a_AIj 7=@2Ei C:89EjQ DC4lQ9EEADi^^5aK_8f286D^aeadh^`g`_h056E2:=06>365a];A8n`fgfef_dcdQ 4=2DDlQ?@E6\7=@2E\C:89EQ ^mkDEC@?8mr@?D:56C $:?8=6\$6DD:@? x?E6CG6?E:@?Dk^DEC@?8mk^9cmkAm%96 7:CDE DE6A :D 2=H2JD E96 92C56DE H96? :E 4@>6D E@ D666?E2= 962=E9 DFAA@CE[ 2?5 ?@E 6G6CJ DECF88=:?8 J@F?8 A6CD@? :D C625J @C 23=6 E@ D66 2 E96C2A:DE] (:E9 2446DD E@ 7C66[ 4@?7:56?E:2=[ D6=7\8F:565 >2E6C:2=D E@ 368:? 3F:=5:?8 >6?E2= H6==?6DD D2J 36 =6DD D42CJ]k^Am kAm$:?8=6\$6DD:@? x?E6CG6?E:@?D W$$xDX 2C6 3C:67[ DECF4EFC65 @?=:?6 4@FCD6D 56D:8?65 E@ E6249 J@FE9 AC24E:42= D@@5[ D6=7\:>286 2?5 >@C6] %96 #FC2= *@FE9 |6?E2= (6==?6DD !C@8C2> @776CD $$xD :? A2CE?6CD9:A H:E9 !C@;64E *t$ W*@FE9 t>A@H6C>6?E 2?5 $FAA@CEX[ 2 7C66 5:8:E2= C6D@FC46 56G6=@A65 H:E9 }@CE9H6DE6C? &?:G6CD:EJ’D {23 7@C $42=23=6 |6?E2= w62=E9 2E E96 u6:?36C8 $49@@= @7 |65:4:?6]k^AmkAmp?@?J>@FD 2446DD E@ $$xD E9C@F89 E96 A2CE?6CD9:A AC@G:56D DEC2E68:6D 7@Cik^AmkF=mk=:mx>AC@G:?8 >@@5k^=:mk=:m#6E9:?286k^=:mk=:m#67C2>:?8 ?682E:G6 E9@F89EDk^=:mk=:mz?@H:?8 J@FC A@H6C E@ 492?86k^=:mk=:m%2
3 Steps to Support Mental Health for Rural Youth
× This page requires Javascript. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. kAmWu62EFC6 x>A24EX *@F?8 A6@A=6 7246 2 8C@H:?8 ?F>36C @7 AC6DDFC6D[ :?4=F5:?8 24256>:4 6IA64E2E:@?D[ D@4:2= C6DA@?D:3:=:E:6D[ 4@>A=6I 72>:=J D:EF2E:@?D 2?5 F?46CE2:?EJ 23@FE E96:C @H? 7FEFC6D] |6?E2= 962=E9 DFAA@CE :D :>A@CE2?E 7@C 2== – 3FE :? >2?J CFC2= 2C62D[ E9@D6 AC6DDFC6D 2C6 6G6? 8C62E6C]k^AmkAmp44@C5:?8 E@ E96 r6?E6CD 7@C s:D62D6 r@?EC@= 2?5 !C6G6?E:@?[ E96 DF:4:56 C2E6 7@C CFC2= J@FE9 286D `d\`h :D fcT 9:896C E92? E96:C FC32? 4@F?E6CA2CED] q2CC:6CD =::E65 :?DFC2?46 4@G6C286[ F?C6=:23=6 :?E6C?6E 7@C E6=6962=E9[ D42C46 AC@G:56CD[ =@?8 5C:G6 E:>6D 2?5 =24< @7 AF3=:4 EC2?DA@CE2E:@? >26?E2= 962=E942C6 H96? :E’D ?66565] !=FD[ 2D2E:K2E:@?]k^AmkAm%92E’D H9J #FC2= |:?5D[ E96 @?=J ?@?AC@7:E 7@4FD65 @? >6?E2= 962=E9 7@C CFC2= 4@>>F?:E:6D[ 4C62E65 E96 #FC2= *@FE9 |6?E2= (6==?6DD A:=@E AC@8C2> DFAA@CE65 3J q@69C:?86C x?86=96:>] xE H2D 56G6=@A65 3J 2? 25G:D@CJ 4@>>:EE66 >256 FA @7 CFC2= J@FE9 E@ AC@G:56 E96:C A66CD H:E9 AC24E:42=[ 7C66[ 2446DD:3=6 >6?E2= 962=E9 C6D@FC46D] x?4@CA@C2E:?8 7665324< @? E96 A:=@E[ E96 FA52E65 AC@8C2> DA@?D@C65 3J E96 $@>A@ u@F?52E:@? :D ?@H =2F?49:?8 :ED ?2E:@?2= C@==@FE]k^AmkAm“p J@F?8 A6CD@?’D +x! 4@56 D9@F=5 ?6G6C 56E6C>:?6 H96E96C E96J 42? 2446DD >62?:?87F= >6?E2= 962=E9 DFAA@CE H96C6 2?5 H96? E96J ?665 :E[” D2:5 y6DD:42 {] $49=6:56C[ !9]s][ 5:C64E@C[ {23 7@C $42=23=6 |6?E2= w62=E9[ }@CE9H6DE6C? &?:G6CD:EJ] “~FC =23 :D E9C:==65 E@ A2CE?6C H:E9 #FC2= |:?5D 2D E96J 492>A:@? 6G:56?46\32D65[ 2?@?J>@FD[ 7C66=J 2G2:=23=6 DFAA@CE E@@=D 56D:8?65 E@ @G6C4@>6 32CC:6CD E@ 96=A\D666?E2= 962=E9 4C:D:D 27764ED J@F @C 2 =@G65 @?6[ 4@?D:56C E96D6 H2JD E@ 96=A]k^Amk9cmkDEC@?8mqC62< E96 $E:8>2 $FCC@F?5:?8 |6?E2= w62=E9k^DEC@?8mk^9cmkAmx? 4@>>F?:E:6D H96C6 D6=7\C6=:2?46 :D G2=F65[ 2D6E:>6D 36 G:6H65 2D 2 D:8? @7 H62>F?:EJ =6256CD 2?5 A66CD 42? H@C< E@ 492?86 E92E 4F=EFC6 3J ?@C>2=:K:?8 >6?E2= 962=E9 4@?G6CD2E:@?D] %9:D :?4=F56D 96=A:?8 E66?286CD 766= D66? 2?5 2446AE65 3J 65F42E:?8 E96> @? >6?E2= 962=E9 :DDF6D 2?5 4@A:?8 DEC2E68:6D[ =:DE6?:?8 E@ E96:C 6IA6C:6?46D H:E9@FE ;F58>6?E[ D92C:?8 J@FC @H? DE@C:6D 2?5 C6>:?5:?8 E96> :E’D 4@FC286@FD E@ D66< DFAA@CE]k^Amk9cmk:>8 DEJ=6lQH:5E9i d__AIj A255:?8\3@EE@>i `_AIj A255:?8\=67Ei a_AIj 7=@2Ei C:89EjQ DC4lQ9EEADi^^5aK_8f286D^aeadh^`g`_h056E2:=06>365a];A8n`fgfef_dcdQ 4=2DDlQ?@E6\7=@2E\C:89EQ ^mkDEC@?8mr@?D:56C $:?8=6\$6DD:@? x?E6CG6?E:@?Dk^DEC@?8mk^9cmkAm%96 7:CDE DE6A :D 2=H2JD E96 92C56DE H96? :E 4@>6D E@ D666?E2= 962=E9 DFAA@CE[ 2?5 ?@E 6G6CJ DECF88=:?8 J@F?8 A6CD@? :D C625J @C 23=6 E@ D66 2 E96C2A:DE] (:E9 2446DD E@ 7C66[ 4@?7:56?E:2=[ D6=7\8F:565 >2E6C:2=D E@ 368:? 3F:=5:?8 >6?E2= H6==?6DD D2J 36 =6DD D42CJ]k^AmkAm$:?8=6\$6DD:@? x?E6CG6?E:@?D W$$xDX 2C6 3C:67[ DECF4EFC65 @?=:?6 4@FCD6D 56D:8?65 E@ E6249 J@FE9 AC24E:42= D@@5[ D6=7\:>286 2?5 >@C6] %96 #FC2= *@FE9 |6?E2= (6==?6DD !C@8C2> @776CD $$xD :? A2CE?6CD9:A H:E9 !C@;64E *t$ W*@FE9 t>A@H6C>6?E 2?5 $FAA@CEX[ 2 7C66 5:8:E2= C6D@FC46 56G6=@A65 H:E9 }@CE9H6DE6C? &?:G6CD:EJ’D {23 7@C $42=23=6 |6?E2= w62=E9 2E E96 u6:?36C8 $49@@= @7 |65:4:?6]k^AmkAmp?@?J>@FD 2446DD E@ $$xD E9C@F89 E96 A2CE?6CD9:A AC@G:56D DEC2E68:6D 7@Cik^AmkF=mk=:mx>AC@G:?8 >@@5k^=:mk=:m#6E9:?286k^=:mk=:m#67C2>:?8 ?682E:G6 E9@F89EDk^=:mk=:mz?@H:?8 J@FC A@H6C E@ 492?86k^=:mk=:m%2
3 Steps to Support Mental Health for Rural Youth
× This page requires Javascript. Javascript is required for you to be able to read premium content. Please enable it in your browser settings. kAmWu62EFC6 x>A24EX *@F?8 A6@A=6 7246 2 8C@H:?8 ?F>36C @7 AC6DDFC6D[ :?4=F5:?8 24256>:4 6IA64E2E:@?D[ D@4:2= C6DA@?D:3:=:E:6D[ 4@>A=6I 72>:=J D:EF2E:@?D 2?5 F?46CE2:?EJ 23@FE E96:C @H? 7FEFC6D] |6?E2= 962=E9 DFAA@CE :D :>A@CE2?E 7@C 2== – 3FE :? >2?J CFC2= 2C62D[ E9@D6 AC6DDFC6D 2C6 6G6? 8C62E6C]k^Am#placement_725937_0_i{width:100%;margin:0 auto;}var rnd = window.rnd || Math.floor(Math.random()*10e6);var pid725937 = window.pid725937 || rnd;var plc725937 = window.plc725937 || 0;var abkw = window.abkw || '';var absrc = 'https://ads.empowerlocal.co/adserve/;ID=181918;size=0x0;setID=725937;type=js;sw='+screen.width+';sh='+screen.height+';spr='+window.devicePixelRatio+';kw='+abkw+';pid='+pid725937+';place='+(plc725937++)+';rnd='+rnd+';click=CLICK_MACRO_PLACEHOLDER';var _absrc = absrc.split("type=js"); absrc = _absrc[0] + 'type=js;referrer=' + encodeURIComponent(document.location.href) + _absrc[1];document.write('');kAmp44@C5:?8 E@ E96 r6?E6CD 7@C s:D62D6 r@?EC@= 2?5 !C6G6?E:@?[ E96 DF:4:56 C2E6 7@C CFC2= J@FE9 286D `d\`h :D fcT 9:896C E92? E96:C FC32? 4@F?E6CA2CED] q2CC:6CD =::E65 :?DFC2?46 4@G6C286[ F?C6=:23=6 :?E6C?6E 7@C E6=6962=E9[ D42C46 AC@G:56CD[ =@?8 5C:G6 E:>6D 2?5 =24< @7 AF3=:4 EC2?DA@CE2E:@? >26?E2= 962=E942C6 H96? :E’D ?66565] !=FD[ 2D2E:K2E:@?]k^AmkAm%92E’D H9J #FC2= |:?5D[ E96 @?=J ?@?AC@7:E 7@4FD65 @? >6?E2= 962=E9 7@C CFC2= 4@>>F?:E:6D[ 4C62E65 E96 #FC2= *@FE9 |6?E2= (6==?6DD A:=@E AC@8C2> DFAA@CE65 3J q@69C:?86C x?86=96:>] xE H2D 56G6=@A65 3J 2? 25G:D@CJ 4@>>:EE66 >256 FA @7 CFC2= J@FE9 E@ AC@G:56 E96:C A66CD H:E9 AC24E:42=[ 7C66[ 2446DD:3=6 >6?E2= 962=E9 C6D@FC46D] x?4@CA@C2E:?8 7665324< @? E96 A:=@E[ E96 FA52E65 AC@8C2> DA@?D@C65 3J E96 $@>A@ u@F?52E:@? :D ?@H =2F?49:?8 :ED ?2E:@?2= C@==@FE]k^AmkAm“p J@F?8 A6CD@?’D +x! 4@56 D9@F=5 ?6G6C 56E6C>:?6 H96E96C E96J 42? 2446DD >62?:?87F= >6?E2= 962=E9 DFAA@CE H96C6 2?5 H96? E96J ?665 :E[” D2:5 y6DD:42 {] $49=6:56C[ !9]s][ 5:C64E@C[ {23 7@C $42=23=6 |6?E2= w62=E9[ }@CE9H6DE6C? &?:G6CD:EJ] “~FC =23 :D E9C:==65 E@ A2CE?6C H:E9 #FC2= |:?5D 2D E96J 492>A:@? 6G:56?46\32D65[ 2?@?J>@FD[ 7C66=J 2G2:=23=6 DFAA@CE E@@=D 56D:8?65 E@ @G6C4@>6 32CC:6CD E@ 96=A\D666?E2= 962=E9 4C:D:D 27764ED J@F @C 2 =@G65 @?6[ 4@?D:56C E96D6 H2JD E@ 96=A]k^Amk9cmkDEC@?8mqC62< E96 $E:8>2 $FCC@F?5:?8 |6?E2= w62=E9k^DEC@?8mk^9cmkAmx? 4@>>F?:E:6D H96C6 D6=7\C6=:2?46 :D G2=F65[ 2D6E:>6D 36 G:6H65 2D 2 D:8? @7 H62>F?:EJ =6256CD 2?5 A66CD 42? H@C< E@ 492?86 E92E 4F=EFC6 3J ?@C>2=:K:?8 >6?E2= 962=E9 4@?G6CD2E:@?D] %9:D :?4=F56D 96=A:?8 E66?286CD 766= D66? 2?5 2446AE65 3J 65F42E:?8 E96> @? >6?E2= 962=E9 :DDF6D 2?5 4@A:?8 DEC2E68:6D[ =:DE6?:?8 E@ E96:C 6IA6C:6?46D H:E9@FE ;F58>6?E[ D92C:?8 J@FC @H? DE@C:6D 2?5 C6>:?5:?8 E96> :E’D 4@FC286@FD E@ D66< DFAA@CE]k^Amk9cmk:>8 DEJ=6lQH:5E9i d__AIj A255:?8\3@EE@>i `_AIj A255:?8\=67Ei a_AIj 7=@2Ei C:89EjQ DC4lQ9EEADi^^5aK_8f286D^aeadh^`g`_h056E2:=06>365a];A8n`fgfef_dcdQ 4=2DDlQ?@E6\7=@2E\C:89EQ ^mkDEC@?8mr@?D:56C $:?8=6\$6DD:@? x?E6CG6?E:@?Dk^DEC@?8mk^9cmkAm%96 7:CDE DE6A :D 2=H2JD E96 92C56DE H96? :E 4@>6D E@ D666?E2= 962=E9 DFAA@CE[ 2?5 ?@E 6G6CJ DECF88=:?8 J@F?8 A6CD@? :D C625J @C 23=6 E@ D66 2 E96C2A:DE] (:E9 2446DD E@ 7C66[ 4@?7:56?E:2=[ D6=7\8F:565 >2E6C:2=D E@ 368:? 3F:=5:?8 >6?E2= H6==?6DD D2J 36 =6DD D42CJ]k^AmkAm$:?8=6\$6DD:@? x?E6CG6?E:@?D W$$xDX 2C6 3C:67[ DECF4EFC65 @?=:?6 4@FCD6D 56D:8?65 E@ E6249 J@FE9 AC24E:42= D@@5[ D6=7\:>286 2?5 >@C6] %96 #FC2= *@FE9 |6?E2= (6==?6DD !C@8C2> @776CD $$xD :? A2CE?6CD9:A H:E9 !C@;64E *t$ W*@FE9 t>A@H6C>6?E 2?5 $FAA@CEX[ 2 7C66 5:8:E2= C6D@FC46 56G6=@A65 H:E9 }@CE9H6DE6C? &?:G6CD:EJ’D {23 7@C $42=23=6 |6?E2= w62=E9 2E E96 u6:?36C8 $49@@= @7 |65:4:?6]k^AmkAmp?@?J>@FD 2446DD E@ $$xD E9C@F89 E96 A2CE?6CD9:A AC@G:56D DEC2E68:6D 7@Cik^AmkF=mk=:mx>AC@G:?8 >@@5k^=:mk=:m#6E9:?286k^=:mk=:m#67C2>:?8 ?682E:G6 E9@F89EDk^=:mk=:mz?@H:?8 J@FC A@H6C E@ 492?86k^=:mk=:m%2
The core anti-Pangram constituency is phony writers
Welcome to The Closing Argument, our verdict on the news, plus everything The Argument published and appeared in this week. The Verdict, by Kelsey Piper A lot of people hate AI for drowning the internet in slop and displacing human creatives. You might think that these people would be thrilled by a program that can identify and flag AI-generated work. But many people who hate AI also hate Pangram, an impressively accurate AI detector that produces very few false positives, according to high-quality independent research. This loathing found its most recent expression in a bizarre Wired article that amplifies a wide range of false arguments from Pangram skeptics: that AI detectors are racist (they’re not) or ableist (they’re not)1 or don’t work (this one does)2. Rather than starting from the premise that it would be really valuable to have a working AI detector and scrutinizing Pangram to make sure it lives up to that promise, the article starts from the premise that Pangram obviously has bad vibes and sets out to discover why. (One answer: The CEO microwaved lunch during an interview!) Why aren’t writers who resent Pangram more eager to distinguish themselves from posters who are having ChatGPT ghostwrite all their work? There are a few different things at play, but I think one key dynamic is this: These are often the same people. A core constituency for arguments like Wired’s is “writers” who are using AI to write their posts but resent this fact being made public. They stand to lose from AI detectors because AI detectors call them out. Share When Substack announced a partnership with Pangram, a sizable fraction of the platform’s authors rose up in outrage. Some people had experience with other AI detectors that didn’t work, and some felt that AI writing ought to be encouraged — both of which are fair enough. But the fury was fueled by authors passionately insisting that Pangram kept wrongly accusing them on almost every post they published. Pangram can be wrong, especially on short passages. But in the overwhelming majority of cases where Pangram looked at a whole blog post rather than a single paragraph, the program correctly detected work as AI. Even if we can’t be 100% sure in any individual case, we can notice the trend in the aggregate. Wired quotes Sam Illingworth, a professor of critical AI literacy at Edinburgh Napier University, who said, “I don’t think [AI detectors] work. … I think that detectors are prejudiced against certain people.” This spring, he said that he used AI for research and editing; this summer he acknowledged that in addition to research and editing, he also uses it “now and then for a turn of phrase I keep.” Pangram informs us that most of his posts are 100% AI-written (some are mixed AI-and-human) and that 100% AI-written posts started appearing last year. The favorable interpretation is that, as someone whose recent work Pangram consistently mistakes for AI, Illingworth sees Pangram’s flaws firsthand. The unfavorable interpretation is that the tool’s credibility trades off against his own, because its account of who writes his posts is not consistent with his. Illingworth is not alone in insisting the detector does not work. “It’s a Monday night in late July, and I’m pasting my own Substack draft into an AI detector for the first time. Not because I’m worried. Because I’m curious. I wrote every word of it myself, the way I write everything, out loud in my head first, in a rhythm that still carries the accent of a language I learned to think in before I learned to write in this one,” begins one Substack post by an author indignant that Pangram flags her writing as AI. “That’s the part I had to sit with before I could write this.” If you, like me, have worked with AIs a lot, you won’t even need Pangram there. The author of that piece is AI. It is obviously AI! I checked 10 other posts on the blog, and they were also obviously AI! “I have spent 22 years as an award-winning author and essayist. And now this bullshit tool that learned from MY writing is going to accuse me of plagiarism,” popular Substack writer Carlyn Beccia wrote in an anti-Pangram post. “For the last and final time, AI DETECTORS DO NOT WORK.” Here’s what her writing sounded like in 2020: “Most success stories revolve around one person who believed enough in you to say — give it a try. We call these people muses, but they are so much more than that. They are the strong man giants whose shoulders we stand on so we can see the horizon. Throughout the editing process, I am sure my editor felt less like a giant of greatness and more like Atlas with the world on her shoulders.” Pangram says it was 100% human-written. (So were other articles of hers in 2020.) And here’s what it sounds like now: “And then there is the reshuffling, which sounds like paperwork until you remember that empires have always loved paperwork. The Trump regime recently moved special education oversight from the Education Department to HHS. That is not a minor bureaucratic transfer. It changes the frame.”3 Pangram says this is mostly AI. I am not convinced that Pangram is wrong. In my own experience, Pangram is very effective on long texts — if it marks a long essay as AI, the essay was either written by AI or deliberately written to sound like AI. On tweet-length or paragraph-length texts, it’s not perfectly reliable. It seems to work just as well for non-native English speakers as for native speakers. While I have seen dozens of claims of pre-2022 text returning a positive result on Pangram, I have tried repeatedly to corroborate those and have never once succeeded. To be clear, I’m absolutely not saying that complaining about Pangram suggests a writer is a cheat. There are plenty of other concerns. Most are mistakenly premised, such as the false claim that Pangram trains on work you put into it, but others are reasonable: It’s unreliable on sufficiently short text segments; it creates an internet witch-hunt mentality when there are defensible uses of AI; people who are open about their AI use are sometimes blamed, when the only people really doing something wrong are the ones who hide it; and it isn’t perfect, so a single positive result shouldn’t be taken as decisive proof of misconduct. I’m happy to concede that Pangram is imperfect and possible to over-rely on. If an author’s posts are mostly non-AI and one scans as partially AI, this could be a mistake. It’s also possible to defeat Pangram with intentional effort. If you think we need something more robust and more reliable, fine! But if you don’t like AI and don’t like Pangram, your attitude really ought to be that it’s a shame that our existing tools for AI detection are imperfect, and it’s important to invent better ones. If your stance is instead that AI is evil and so is looking for AI, then ultimately you’re contributing to the sloppification of the internet. You’re making it harder for people who write their own text to distinguish themselves, and providing cover for authors who are definitely not writing their own text. Subscribe Top stories this week, by Kobe Yank-Jacobs Commentators often worry that the decline of reading could mean the decline of liberal democracy — but deliberative governance actually predated widespread literacy. This week, Maibritt Henkel pointed out that many liberal cultures thrive on a culture of raucous, interactive debate, which can happen in-person as easily, if not more so, than in text. Read on, dear reader, to learn more. It may actually cheer you up: [ ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) [ Reading won’t save liberalism ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) Maibritt Henkel · Sep 1 [ Read full story ](https://www.theargumentmag.com/p/reading-wont-save-liberalism) It used to be bad to downplay climate change (if we mean denying its reality). Today, it’s actually good to downplay climate change (if we mean keeping the issue out of political fights so we can make real progress). This counterintuitive view is called “climate hushing,” and contributor Alex Trembath argued that it’s the key to enacting good policy going forward. Get up to speed on the latest in climate politics: [ ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) [ We won’t stop climate change by talking about it ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) Alex Trembath · Sep 2 [ Read full story ](https://www.theargumentmag.com/p/we-wont-stop-climate-change-by-talking) Canada’s Prime Minister Mark Carney is standing up for the forces of liberalism against Donald Trump’s assault on our closest ally. So, why is one prominent left-wing commenter attacking Carney? Columnist Matthew Yglesias explains: [ ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) [ When "economic liberty" means central planning ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) Matthew Yglesias · Aug 31 [ Read full story ](https://www.theargumentmag.com/p/when-economic-liberty-means-central) 🌟Abundance Wins of the Week🌟 Shout out to my home state of California, whose legislature passed two housing bills this week. One requires a housing density minimum in transit-oriented areas of the state’s most transit-rich cities (Los Angeles, Sacramento, San Francisco, Oakland, San Jose, San Diego, and Long Beach). Another bill closes two common loopholes used by third parties to delay housing projects, including an opportunity to challenge maps of a given lot created by the developer after a project has been approved. Shout out to our big-state rival, Texas, where pro-housing SB 785 took effect this week. The new state law requires municipalities to have at least one district permitted for manufactured housing without a special permit. This will promote zoning changes in 44% of municipalities. The company Fervo Energy signed a deal with Google for what is set to be the world’s largest enhanced geothermal facility, proving a technology can work at a scale that could be crucial to a decarbonized, energy-abundant economy. Share Worth watching… This week, forecasting legend Nate Silver joined Jerusalem, Matt, and Jeremiah on a crowded episode of the pod. It was a party. And speaking of parties, our round table debated the factional lines within the Democratic Party: Is it possible to be center-left and also anti-establishment? Watch or listen to find out: The Rio Grande Valley in Texas is one of the areas that swung hardest toward Trump in 2024, but musician Bobby Pulido is running to flip it back. Right now, The Argument/Split Ticket’s model has him running 1.1 points behind his Republican opponent in a district Trump won by 18 points. Tune in to find out how he differs from national Democrats and what he thinks he can to do win this seat. On Thursday, Bernie Sanders was among the first politicians to call for a ban on superintelligence. My guest this week, Andrea Miotti, has been lobbying to ban superintelligence for several years, most recently in the U.K., U.S., and Canada. I asked him how he gets legislators to take speculative risks seriously, and we dug into what plans might look like to actually pass a ban. Listen to learn more: What’s News with The Argument The Argument recommends, by Kobe Yank-Jacobs If we ever lose track of Justin Zuckerman, I’ll have the team split up and check all the movie theaters in the city. I’m shocked (and a little jealous) at how often he gets out to see good cinema. This week, he brings us It Ends, a “horror-ish movie,” which he described as a “Gen Z Waiting for Godot.” I was intrigued before he added that it was “funny, dark and existential” — at which point I was fully locked in. I guess I also had existential themes on the mind this week. One morning, a single line from a poem I read long ago just came to me: “Is death a stretch of time in which a life is just a flash?” The poem is called “From 20,000 Feet” by Heather McHugh. I suggest the version in The Vintage Book of Contemporary American Poetry, which, by tradition, my best friend and I always bring backpacking, extra weight be damned. We’ll stay thematically dark for just one more rec from senior editor John Robert Thomason, whose upcoming trip to Baltimore reminded him to suggest Michael Clune’s memoir White Out (about being addicted to heroin in Baltimore in the 1990s). Ben Lerner’s blurb called it _“_Disturbing, brilliant, hilarious—it’s as if Proust had written Jesus’ Son.” John told me this “seems accurate, with the caveat that I’ve never read Proust.” I, personally, have also shelved Proust until retirement. At this point, I was a little concerned for the team since all of us tossed out such psychologically grim material — maybe we’re all down about the end of summer — but thankfully, at least a few of us were into more upbeat selections. Milan Singh recommended Made In’s 5-quart stainless clad saucier, suggesting he had some fun in the kitchen. Jeremiah Johnson asked if he could recommend yet more Carly Rae Jepsen. Once denied, he offered up Game Changer instead_,_ calling it “the most wildly creative game show, maybe in the entire history of the genre.” Eli Richman mentioned _Lucky, “_a B-tier show with an A-tier cast and an S-tier theme song.” I suppose he was recommending the song, Horns of a Bull. Still, despite these cheerier recs, I couldn’t help but be concerned that we were subconsciously worried about racing toward summer’s end — the end of swim trunks and splashing around. Then a message landed reminding me of the three-day weekend to come. A whole extra day for sunshine. One more swim in the lake. I was grateful this called to mind yet another line from a poem, one by Mary Oliver, the patron saint of every gorgeous summer day (and about whom a documentary is now out). Speaking to God in the poem “Thirst,” she wrote: grant me, in your mercy,a little more time. Love for the earthand love for you are having such a longconversation in my heart. We have merch! We have quarter-zips, keychains, hats, and stickers. Each one is a great conversation starter in its own way. Buy them here. Subscribe More to read: [ The Opening Argument ](https://www.theargumentmag.com/p/seeing-like-an-elite)[ Seeing like an elite ](https://www.theargumentmag.com/p/seeing-like-an-elite) Kobe Yank-Jacobs · Sep 4 What do Americans hear when they watch Sen. Bernie Sanders or Vice President JD Vance rail against the elite? Are they thinking of right-wing tech billionaires? Imperious college professors? Liberal magazine writers? [ Read full story ](https://www.theargumentmag.com/p/seeing-like-an-elite) [ The Weekly Scroll ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline)[ God is back on the timeline ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline) Jeremiah Johnson · Sep 5 This week, we’re talking about Substack’s new religious debates, the continuing MAGA influencer scandal, how to retire from YouTube, and aura battles. [ Read full story ](https://www.theargumentmag.com/p/god-is-back-on-the-timeline) 1 This was a legitimate thing to worry about, but doesn’t seem to be a problem given the actual technology: Marijke Van Vlasselaer, Filip Van Droogenbroeck, and Bram Spruyt’s 2026 paper looks at whether Pangram is less accurate when evaluating the work of non-native speakers of English. It isn’t. That’s because Pangram isn’t really looking at how “unusual” a piece of writing is but whether it has the characteristic patterns of LLMs. The Wired article makes an odd gesture at a different Pangram-is-racist argument. There were several controversies this summer during which upcoming books were canceled after being discovered to be AI-written: “The three novels mentioned earlier — Shy Girl, Daggermouth, and Call Me, easily publishing’s biggest AI-detection scandals — were all written by writers of color.” But come on! As Zvi Mowshowitz put it: “They were not primarily written by people of color. They were primarily written by AIs.” That’s the whole problem! And as my colleague Jeremiah Johnson recently observed with respect to Cambridge’s Arday scandal, a community being unwilling to call out fraud if it’s perpetuated by people of color is not an anti-racist tendency; it is ultimately quite racist. 2 Many non-Pangram detectors don’t work, but many possible airplane designs also don’t work, and no one considers this a general argument against aviation; the thing that matters is whether any detection works. 3 The phrase “empires have always loved” mysteriously became all the rage in the last few years. See here, here, here, here and here. Before 2025, the only use of that phrase I have been able to find is a single Tweet. The logic of the sentence, too, is incoherent in an AI-characteristic way. “...sounds like paperwork, until you remember that empires have always loved paperwork”? Does remembering that make it sound less like paperwork? It’s a craft-ful sentence, but what is it actually saying??
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Vice President JD Vance will attend the New York observance and other administration officials will go to the ceremony in Shanksville, Pennsylvania
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In this special episode of Politics Unusual, FOX 5 NY's Teresa Priolo speaks with NJ Transit President and CEO Kris Kolluri about the $4 million loss during the World Cup. Also, a conversation with State Senator Andrew Gounardes about protecting children from the negative effects of social media.