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Steelers Paid Massive Price for Drops in Week 1
The Pittsburgh Steelers are going to want to look away from this concerning stat from Week 1.
One Year Of America First Global Health Strategy: Controversy, Secrecy And Suffering
Country controversies, secret terms, opaque procurement, and massive unspent congressional funds have characterised the first year of the America First Global
Devastated Walhalla business owners consider next steps after fire
Impacted business owners in Walhalla are reeling and basically starting over from scratch - with tens of thousands of dollars of equipment and products destroyed - after a massive fire Thursday morning.
Ole Miss vs LSU: A Magnolia Bowl Preview
It's a matchup roughly nine months in the making, but at long last, we've finally made it. Week three of the college football season gives us Ole Miss vs. LSU, and this year it's a Magnolia Bowl with massive storylines. Number one is obviously former Rebel head coach Lane Kiffin returning to Oxford as the …
Chargers CB Tarheeb Still is Facing a Massive Season
Tarheeb Still enters 2026 with a huge opportunity to establish himself as the Chargers’ top cornerback. With questions surrounding the lack of a true star at the position, Still has a chance to prove he can be the leader this secondary needs.
Massive Jump In Miami Heat National TV Games Much Deserved
The Miami Heat are stepping into a much bigger national spotlight for the 2026-27 NBA season. After just five nationally televised games in 2025-26, the number of Miami Heat national TV games will jump to 31 this season (including NBA TV). That's an increase of 26 games, reflecting a dramatic shift in the attention surrounding …
Why Cubs have massive bullpen problem before MLB postseason
This could be a major issue for the Cubs.
How Trey Yesavage Can Help Toronto Blue Jays Down Stretch
The Blue Jays enter Friday's massive series opener in Arlington at 1.5 games back in the wild card race.
Committee advances farm bill with McConnell's vote
A Senate committee narrowly approved a massive agricultural bill Wednesday, with Sen. Mitch McConnell providing the decisive vote.
Detroit Lions Could Get Massive Defensive Reinforcements After Bills Game
Brian Branch and Kerby Joseph become eligible to open 21-day practice windows after Week 2, though neither can play until Week 5.
Dartmouth Health announces massive staff and program cuts
Dartmouth Health announced layoffs of 124 employees and the elimination of 303 jobs to improve long-term sustainability.
Earth lost more than 12 trillion tons of ice from Greenland and Antarctica in 47 years, satellites show
A major report has found that 12.5 trillion tons of ice from Greenland and Antarctica have melted since 1979. The massive glacier melt is mainly attributed to warmer waters eroding the ice sheets from below and the sides.
Scientists Observe Quantum Entanglement In The Extreme
An international team of researchers witnessed a strange phenomenon of quantum physics in Z bosons, massive particles that vanish almost as soon as they appear.
Scientists discover metabolite fueling aggressive brain tumor growth
Virtually all high-grade, aggressive gliomas in adults accumulate massive amounts of a metabolite called guanidinoacetate (GAA) that overstimulates nearby neurons and promotes tumor growth, according to new research from scientists at Children’s Medical Center Research Institute at UT Southwestern (CRI) published in Cell.
ESPN rewards Joe Buck with massive Monday Night Football extension
ESPN is keeping its primary MNF voice for at least another six NFL seasons.
Dartmouth Health announces massive staff and program cuts
Dartmouth Health announced layoffs of 124 employees and the elimination of 303 jobs to improve long-term sustainability.
UT unveils ’865 Neyland,’ new renderings for Neyland Stadium entertainment district
‘865 Neyland’ has been officially unveiled as the name of the massive new entertainment district and 24-story hotel tower coming next to Neyland Stadium
Fire Emblem: Fortune's Weave Review: Let The Games Begin
Fire Emblem: Fortune's Weave (Switch 2) Review – 8.75/10: Fortune's Weave is the latest entry in the Fire Emblem series, and it is both massive and worth the time investment. - Game Informer
First M6 benchmarks reveal how much raw power the Mac mini has
The first benchmarks for the M6 Mac mini have emerged. While Moore's Law is in fact dead, the Mac mini is still getting a massive and noticeable boost in processing performance.
Supermassive black hole winds are 100 times more powerful than scientists thought
Astronomers have discovered that winds from a supermassive black hole are about 100 times more powerful than previously thought. XRISM observations showed the resulting turbulence spreading roughly 300,000 light-years, extending far beyond the black hole’s host galaxy. The energy involved rivals several billion supernova explosions, revealing just how dramatically black holes can influence the space around them.
Recruiting Roundup: OU win fuels massive recruiting weekend for Michigan
Saturday’s win vs Oklahoma was huge for Michigan Football, including for recruiting. Check out the latest recruit reactions in today’s Recruiting Roundup:
Shaky Rumour Claims Xbox Game Pass Could Be Getting Major Changes In 2027
Take with a massive pinch of salt
Lean in: Tilt Studio planning Tallahassee debut
Tallahassee is set to welcome a massive new Tilt Studio entertainment center at the Governor's Square mall next year.
Hidden Ocean Deep Inside Earth? Scientists Uncover Evidence Of Massive Water Reservoir
Scientists have found two new minerals that could trap huge amounts of water deep inside Earth, near the boundary between the mantle and the core.
Scientists to probe the source behind a massive 1946 tsunami
Eighty years ago, a massive tsunami devastated parts of Hawaii, Alaska, Washington and Oregon following an earthquake off the coast of Alaska. A Michigan State University team is launching a project to ...
Packers’ Former 1st-Round Pick Ready For Year 2 Jump
One of the biggest questions of the Green Bay Packers offseason was how second-year receiver Matthew Golden would look after a disappointing rookie season. While the Packers’ loss to the Minnesota Vikings was a clear disappointment, the team can take some solace knowing that Golden played well in what is expected to be a massive […] The post Packers’ Former 1st-Round Pick Ready For Year 2 Jump appeared first on HEAVY.
NFL Wednesday night season opener was major viewership bust
The NFL's season-opening kickoff saw a notable dip in viewership after the league moved the annual event to Wednesday night. While 25.1 million viewers still represents a massive audience, the decline raises questions about streaming, scheduling and potential football fatigue.
Jayden Bogle: It's a massive result for us
Jayden Bogle found the back of the net in a thrilling first half from Leeds United against Newcastle United, as he helped divert Dominic Calvert-Lewin's initial header into the back of the net.After a...
Scientists map massive layer of life just beneath our feet
Until recently, nobody had visualized the fungal "Wood Wide Web."
Yankees Linked to Massive Offseason Trade for Dynamic Slugger
The New York Yankees have been connected to a trade for a dynamic slugger this MLB offseason.
Wardogs Is a Massive Hit on Steam, and It’s Already on Sale for $33
Wardogs is a new online first-person shooter that has been riding high on the Steam charts since it came out on September 10. You can get it for $33 right now at Fanatical.
Guardians Announce Starting Pitchers for Massive Series vs White Sox
The Cleveland Guardians have announced the starting pitching plan against the Chicago White Sox.
NFL fatigue rankings reveal major hidden disadvantage for Texans, 49ers
A new NFL Fatigue Index reveals the massive travel, rest and body-clock disadvantages facing the Texans, 49ers and other contenders in 2026.
Local canoe business finds strength in community after destructive floods.
Canoe Country is a local canoe-floating business that was hit by the massive recent floods, but the community around it helped them rebuild.
Physicists zoom into the birth of cosmic rainstorms with new CERN study
Scientists recreated cosmic rays in a massive underground particle collider.
Vikings Draft Scouting: Oklahoma State QB Drew Mestemaker
Drew Mestaker just pulled off a massive upset against Oregon and impressed in front of numerous NFL scouts.
NASCAR Chase Standings Are Tight Heading Into Bristol
Two races are down. Eight remain. And the NASCAR Cup Series Chase suddenly has Kyle Larson breathing down Denny Hamlin’s neck. Larson won Sunday at Gateway and jumped from seventh to second. He now trails Hamlin by only nine points. That is a massive swing after one race. Larson Just Changed Everything Kyle Larson entered…
Charles Barkley's Bold Lakers Prediction Is A Massive Stretch
Charles Barkley believes the new-look Los Angeles Lakers could be as good as-or better than-the 2024 Dallas Mavericks team that reached the NBA Finals. The comparison is intriguing after Los Angeles reshaped its roster around Luka Doncic and Austin Reaves. The Mavericks, however, had something the Lakers do not yet have: postseason proof. Barkley predicted […] The post Charles Barkley's Bold Lakers Prediction Is A Massive Stretch appeared first on Stadium Rant.
Trump agrees to new bipartisan ethics provision in massive crypto bill, Republican senators say
President Donald Trump has agreed to a significant portion of a stringent ethics proposal that is part of a broader cryptocurrency bill headed for a key vote this week.
Jahmyr Gibbs Responds to MASSIVE Workload vs. Saints
Jahmyr Gibbs addressed his career-high 29 carries after the Lions beat the Saints, while Dan Campbell explained Detroit's plan for his workload.
Dan Campbell admits Lions “Got One” after controversial replay decision
A controversial replay decision erased a Saints defensive touchdown and gave Jared Goff and the Lions a massive break in their wild 31-30 overtime victory over New Orleans.
Oregon freefalls in latest US LBM Coaches poll after loss
After the crushing loss at Oklahoma State, the Ducks take a massive drop in the US LBM Coaches poll.
Giants Facing One Massive Roadblock in Beating Cowboys
The New York Giants are facing one massive challenge against the Dallas Cowboys.
Fans raise a ruckus over the paywalling of World of Warcraft Forever’s Skyborne ‘cash elves’
As World of Warcraft Forever continues to dominate the conversation among fans after its BlizzCon reveal, another round of chatter is quickly gaining momentum: the matter of the Skyborne race, or as one fan put called them the "cash elves," which is locked behind a paywall and not included with the upcoming variant or game subscription. [...]
Physicists can’t agree on how the Universe works
A massive worldwide survey of physicists has revealed surprisingly little agreement about some of the universe’s biggest mysteries. No majority backed the standard cosmological model, a leading explanation for dark matter, or any single theory of quantum gravity. One area of stronger agreement stood out: 68% said the Big Bang does not necessarily represent the beginning of time. Researchers say the divisions show just how alive and unsettled the frontiers of physics remain.
Rams Defensive Coordinator Under Fire After Disappointing Start
The Los Angeles Rams were massively disappointing on both ends of the field, culminating in a 27-7 loss to the San Fransico 49ers. The post Rams Defensive Coordinator Under Fire After Disappointing Start appeared first on LA Sports Report.
Drew Mestemaker Reacts to Oklahoma State's Massive Upset of Oregon
Oklahoma State quarterback Drew Mestemaker weighed in on his team taking down the Oregon Ducks in a massive upset.
Elly De La Cruz Post-Reds Future Made Clear
The Cincinnati Reds aren’t one of MLB’s big-market teams. They aren’t able to land huge free agents with massive contracts.To compete in the modern game, the Reds have to develop players well, and potentially convince them to stay when given the opportunity.Even then, it can be tough. This season is a clear example. The Reds […] The post Elly De La Cruz Post-Reds Future Made Clear appeared first on HEAVY.
Packers, Tucker Kraft agree to massive 4-year contract extension
Tucker Kraft and the Packers have agreed to a hefty four-year extension.
High school football Super 25 takeaways: Biggest winners, surprising results
From massive blowouts to a game of the week that lived up to the hype, here are the top storylines featuring this week's Super 25 teams.
Detroit Lions create massive cap space with 2 contract restrucutres
The Detroit Lions made MASSIVE contract restructures and now have the second-most cap space in the NFL.
Germany’s Political Tailspin: Your Weekly SPIEGEL Recap
It might be tempting to dismiss the results of last Sunday’s state election in Saxony-Anhalt, in which the far-right Alternative for Germany (AfD) party raked in 43.8 percent of the vote, as a rather unimportant extremist blip in a state that hardly anyone can find on the map. And you wouldn’t necessarily be wrong to do so. The state’s population – around 2.1 million – is a mere 2.5 percent of the German total. And while the state capital of Magdeburg was once the political heart of the Holy Roman Empire back when Otto the Great used to hang out there (more than a millenium … no … milennium … nope … millennium ago), it is today something of a backwater, albeit one with a ginormous cathedral in its center. We wanted to briefly interrupt this week’s newsletter to extend a heartfelt thank you to all of our subscribers, both new and old. And to remind you all that a free subscription gets you access to this newsletter every Saturday. A paid subscription, by contrast, gets you one DER SPIEGEL article every weekday, delivered to your inbox. We strive to select pieces that both demonstrate what Europe’s leading newsmagazine has to offer and provide an international audience – namely, you – with an insight into how Germany and Europe view the world. If you haven’t already signed up for a paid subscription, please consider doing so if you can. Our Substack channel relies entirely on reader support and we are excited to continue offering you the best of DER SPIEGEL. Subscribe But even beyond the fact that a huge percentage of the voters in the state decided to place an X next to a party with an ideological lineage that runs rather directly back to the right-wing extremist soup out of which the Nazi Party was born, the results are a perfect example of a phenomenon that has been plaguing German elections in recent years: the lack of an obvious path to a majority. Call it the Balkanization of German politics. There are a number of developments driving the phenomenon, but for the purposes of this newsletter, here are two of the most salient: Persistent voter frustration with the country’s two (former) big-tent parties – the Christian Democrats (CDU) on the center-right (17.2 percent in Saxony-Anhalt last Sunday) and the Social Democrats (SPD) on the center-left (9.3 percent). The presence of parties on the far left (Left Party), the populist left (the Sahra Wagenknecht Alliance – BSW) and the far right (AfD) with which mainstream parties are reluctant to form coalitions. So what happens now? Stories of the Week A Lack of Leadership The answer for many people in the country, and particularly within the CDU, is clear: pin (some of) the blame on Chancellor Friedrich Merz. According to a survey taken directly after the election in Saxony-Anhalt, 88 percent of respondents agreed with the statement that if the federal government in Berlin were doing a better job, the AfD wouldn’t be as strong. And it is true that the predominant impression of the federal government ever since Merz was sworn in on May 6, 2025, is one of ineffectiveness and bickering. His rather unique combination of bumbling-plus-bravado has also not exactly endeared him to the German public. Indeed, his standing in the country is so shaky that his popularity – according to recent polls – has now dropped even below the historic lows associated with his predecessor Olaf Scholz. The situation is such that the CDU even opted to keep him largely out of the campaign ahead of the Saxony-Anhalt vote. And since then, dissatisfied rumblings within the CDU have grown louder. DER SPIEGEL’s Swantje Karich notes that the problems with the CDU go much deeper than Merz. “The center-right has a trust problem. At a press appearance following the devastating election result in Saxony-Anhalt, Friedrich Merz said that the party wanted to ‘reach people more effectively’ through ‘emotional engagement.’ It sounded as though he were announcing a political program. On the basis of that statement, it is difficult to take his empathy seriously.” “The Chancellor’s chastened appearance did, at least, reveal where he stands: with his back to the wall. Elections will be held in Mecklenburg-Western Pomerania next week, and the CDU could fare even worse there. The party is polling at between 8 and 10 percent in the state.” “What is at stake is the political tradition that has lent stability to the Federal Republic since 1945: a democratic conservatism that understands what must be preserved, but also how to embrace progress and openness to the world. If the Union continues along its current path, it risks becoming politically irrelevant after the 2029 federal election – and Germany could soon find itself with a government of the far right.” The Trumpification of Political Debate? It is often said in Germany that to understand the political and social trends that will soon be dominant in Europe, one need only look across the Atlantic to the United States. When it comes to political debate, that has certainly proven true. Donald Trump understood early on that triggering mouth-foaming outrage among Democrats is an ideal way to both generate headlines and to secure loyalty among supporters. And he realized that far more quickly than the left side of the political spectrum understood that simply ignoring the old man might be the best recipe. To be sure, there have been signs recently that the US president may be over-relying on the strategy. Earlier this week, in an apparent grandpa-discovers-AI moment, Trump sent out 60 posts in the space of 10 hours, many of them AI-assisted images portraying him as a hero – or showing Iceland as part of the US (outrageous!!!). It was also during that slew of schlock that he explicitly backed the AfD with an “MGGA” post. In Germany, though, the outrage cycle remains in full swing, with much of the focus on those who would dare to vote for the AfD. They are alternately portrayed as being dim-witted, ungrateful, backward, racist or all of the above. That, argues DER SPIEGEL columnist Sabine Rennefanz, is not particularly helpful. “Everywhere on election night, people spoke of a watershed moment, a rupture, a turning point. But what is that supposed to mean in concrete terms? A watershed would imply an interruption, a moment of pause – perhaps even a willingness to rethink and learn. At first, there was little sign of that in the main television panels. Instead, the familiar rituals that had already shaped the election campaign continued: outrage, lecturing and abuse.” “That’s just the tone, one might object. They’re only talk shows. Given that the party’s state branch has been classified by domestic intelligence officials as confirmed right-wing extremist, there are more important problems than hurt feelings on television. Yet although the condescending tone is not the cause of the AfD’s success, it is an expression of the broader mood within the so-called political center – a kind of institutional blindness that too often treats material concerns as a communications problem.” “People have a pretty good sense of whether you like them – whether you approach them with curiosity or merely study, lecture and manage them as a problem group. They notice whether you genuinely want to understand their fears and pain, or whether you are simply waiting for the chance to correct them. They can also tell whether someone still has the energy to change things, or whether they have barricaded themselves behind platitudes and empty phrases.” “Anyone who wants an egalitarian democratic society cannot promise equality only to those whose language, tastes and moral convictions they share. They must also acknowledge the wounds, resentments and fears of those whose political conclusions they consider wrong. Acknowledging them does not mean agreeing with them. But a democracy that communicates with almost half its citizens only through warnings and labels gives up on political debate before it has even begun. An atmosphere must be created in which people can express their opinions without fearing that they will be canceled. We are currently a long way from that.” East-West? One of the clear undercurrents in the election last Sunday was, of course, Germany’s ongoing east-west divide, particularly as it pertains to the success of the AfD. Historically, the party has been far stronger in the former East German states than in former West German states. The fact that this generalization no longer reliably holds is certainly one of the primary concerns that many have about the party’s growth. And yet, there is still a distinct flavor of “stupid easterners, they don’t understand democracy” to the coverage. In the weeks before the vote, there was even a rather interesting back-and-forth in Germany’s culture pages about how ungrateful eastern Germans allegedly are for being pulled out of their pre-reunification backwardness and into the light of the West. DER SPIEGEL’s Jochen-Martin Gutsch has had enough. “Ten years ago, in 2016, elections were also held in Saxony-Anhalt. The AfD won more than 20 percent, which at the time rightly provoked outrage and incomprehension in western Germany. Today, in 2026, the AfD is also polling at around 20 percent in western German states, but this no longer provokes outrage and incomprehension. Instead, it is now regarded as proof of democratic conviction and civilizational resistance. After all, in the east, it’s 40 percent!” “This allows people to continue feeling morally superior to the East, but the wiser course would be to admit: if something doesn’t happen soon, the West will turn AfD-blue too. Or bluish.” “But will anything happen? The truly depressing thing about election night was not so much the AfD leaders intoxicated by their own success. It was the representatives of the other parties, who once again said that they were utterly shocked, needed some time to digest the result and would, of course, not simply return to business as usual. The SPD, a former big-tent party, celebrated its ‘stable’ result of 9.3 percent. Congratulations!” “For 10 years, the AfD has gone from one electoral success to the next. And still, the established parties remain ‘shocked’ and scratch their heads in astonishment. How long can they keep being shocked? Friedrich Merz says he may need to communicate his reform ideas in a more ‘emotional’ way. So the CDU’s political professionals sit down together after the election, mull over a strategy, and in the end come up with this: Fritz, try to be a little more relaxed, charismatic and emotional – or something. Beyond that: no political plan, no defiance, no promise of a future. That is frightening.” What was good, what was bad for democracy? Good: Voter turnout in Saxony-Anhalt was 77.8 percent, the highest ever recorded in the state. Whatever one thinks of the result, that figure is encouraging. Democracy needs citizens to take an interest. Bad: Although a strong AfD result had been expected in Saxony-Anhalt, many politicians from the mainstream parties – including in Berlin – appeared confused, helpless and overwhelmed in their initial reactions. That is not how they will win back voters’ trust. Last Week’s Highlights: 🗳️ Meet the Germans Who Voted for the AfD: Why would voters in a country like Germany, with its Nazi past, vote for a right-wing party? It’s a question only an editor in Berlin could come up with. On the ground, the view is different. 🟦 How the AfD Wants to Expand Its Power Across Germany: The far-right AfD is planning to decimate public broadcasting in Saxony-Anhalt, revamp education and install extremists in positions of power. And it is eyeing victory on the national stage as well. 🕯️ The Continuing Reverberations of September 11: It was a generational shock, and the consequences can still be felt today - from massive surveillance and significant increases in presidential power to violent excesses at ICE. 🤝 “For Europe, Canada Is the Preferred Partner in Trans-Atlantic Relations”: In an interview with DER SPIEGEL, Canadian Finance Minister François-Philippe Champagne discusses his country’s failed trade deal with the US and why Canada is looking to Europe. 🏛️ The True Historical Roots of the AfD: During the Weimar Republic in the 1920s, there were numerous parties on the extreme right espousing “Germany first” nationalism. The Nazis may not be the best comparison for today’s AfD. 🌊 AfD in a Landslide: Merz Is the Wrong Leader for Germany: The right-wing Alternative for Germany won in a landslide in Saxony-Anhalt state elections on Sunday. What does that mean for the country at large? Thank you for your continued support and have a wonderful week! Subscribe Share Leave a comment Your SPIEGEL Substack Team Compiled and edited by Charles Hawley
Highlights: Louisville 59, Villanova 13
Dominated like they were supposed to. Got starters some rest. Got the young guys some action. Didn’t suffer any major injuries (as long as KeyJuan is ok). Pretty much all the major boxes checked in this one. Massive, massive opportunity for this team in eight days. Think the fans will recognize the gravity of the […]
Cardinals get massive Jeremiyah Love update ahead of Week 1
The Cardinals are eager to get rookie sensation Jeremiyah Love on the field to start the season, and the latest news on that front is positive.
KSU Shocked by Massive Sellout as Rivalry Fever Hits
Kennesaw State football sold out the Georgia State showdown. See the numbers, the crowd streak, and what this means for Atlanta college sports.
Everyone Wants to Be Around LSU Football
LSU football suddenly feels like the biggest show in college football. And Brooks Nader is the latest name to join the party. The model and social-media personality was around LSU’s massive season opener against Clemson, joining Livvy Dunne and Theo Von as part of the celebrity presence surrounding Lane Kiffin’s debut. Then LSU went out…
GTA 6 Leak Spurs Fake Reviews, Extortion Attempts at Real-Life Nudist Resort Prototype
Following the massive leak of "Grand Theft Auto VI" (GTA 6) gameplay footage by leaker Cyberleek, one particular clip showed protagonist Jason enterin...
Massive Bold Prediction For Orlando Magic Season
Health remains the ultimate gamble as Orlando’s core aims for statistical dominance. With a new head coach and battle-tested stars, the Magic must prove their elite potential.
Defining His Race: How a Charlotte Motorsports Leader Found a New Heart and a Second Chance
After experiencing subtle symptoms one Easter weekend, Charlotte Motor Speedway President and General Manager Greg Walter suffered a massive heart attack that led to cardiac arrest, advanced life support, and a heart transplant at Atrium Health Sanger Heart & Vascular Institute. Today, Greg is back at the track with a renewed perspective on life, leadership and recovery.
Just across the Hudson, the Western Hemisphere’s largest planetarium is getting a massive $40M upgrade—adding a 90-foot upside-down balloon, river otters, and a touching 9/11 Memorial Garden
Liberty Science Center's massive $40M expansion brings a 90-foot upside-down balloon, a touching 9/11 Memorial Garden, and epic planetarium upgrades.
Scientists just witnessed the birth of a double-star system in real time. It's like watching a Star Wars world forming right in front of us | BBC Sky at Night Magazine
Astronomers have captured one of the most detailed 3D views ever recorded of a massive binary star system in the middle of its dynamic birth.
We toured Pensacola's massive new Launch complex. Here's what's coming
See how the Launch entertainment complex, featuring trampolines, bowling, dining, high-tech games and more, is coming along ahead of its October opening.
Dillon Jones News Reveals Thunder Truth Nobody Admits
Sam Presti’s draft gamble on the versatile wing highlights a rare organizational luxury: the massive asset chest required to survive high-stakes misses while chasing elite championship depth.
Scientists are tracking a massive algae bloom moving through the Chesapeake Bay
The bloom has “caused quite a stir” among officials who research the issue.
Shorthanded No. 1 Stanford Faces Massive No. 3 Duke Challenge
A win would prove Stanford women's soccer can beat anyone. A loss would underscore how much the Cardinal are missing some of its top players.
'Tough watch' but 'workmanlike' Celtic get job done
Auston Trusty is just far too weak and that worries me against the teams coming up. Franny: I said it when he signed and I'll say it again, Haissem Hassan is going to be massive for us. Viljami Sinisalo could have a fight on his hands to remain No.1 as Sam Johnstone looks confident.
Statuary brings recognition to businesses
An oversized rooster, a towering sasquatch, or a massive metal eagle might seem like unconventional marketing investments, but Mike Ferguson, owner of Spokane-based Way Out West, has spent over two decades supplying Inland Northwest businesses with statues and large outdoor pieces that are helping turn companies into recognizable landmarks.
Rhode Island could see a political wipeout next week
If Governor Dan McKee, Lieutenant Governor Sabina Matos, and Mayor Brett Smiley all were to fall, it would amount to an unprecedented upending of Rhode Island’s political establishment, and a massive rebuke that could signal a significant shift in the state’s political landscape.
Bears Gifted Massive Advantage Heading Into Regular Season
The Chicago Bears face the toughest schedule in the NFL, but they have it much easier than their opponents in another important way. The post Bears Gifted Massive Advantage Heading Into Regular Season appeared first on HEAVY.
Trump officials expect final approval of massive arch in November
A top National Park Service official, meeting with preservationists, rejected suggestions to change the planned 250-foot-tall arch’s size, design or location.
Georgia Tech’s Season Could Get Ugly Fast
Georgia Tech has a problem. The Yellow Jackets entered 2026 hoping to build off last season and potentially become a legitimate ACC contender. Instead, they’re 0-1 and already facing a massive game. Georgia Tech’s 14-13 loss to Colorado was ugly. The offense didn’t score a single touchdown, Tech managed just 51 rushing yards , committed…
Valheim 1.0's Steam player count soars to a huge 5-year high, but it's not enough to beat the viral survival game's early access peak
Valheim 1.0 is kickstarting a massive resurgence in the survival game's Steam player count, years after becoming a viral phenomenon.
Georgia Fans Are Absolutely Furious About This
Georgia football fans will pay for a lot of things. Tickets. Parking. Donations. Merchandise. Streaming subscriptions. Apparently, game highlights are next. Georgia promoted its traditional “Victory Highlights” video following its 63-3 destruction of Tennessee State , except there was one massive catch. The full video was placed behind the Glory Glory subscription service, which starts…
2 New York Giants named to CBS Sports' preseason All-Rookie team
CBS Sports is bullish on the New York Giants rookie duo making a massive impact in Year 1.
Webinar: The Massive Scale of GLP-1s: Evolving Health, Healthcare and Markets
Watch this discussion on how GLP-1 drugs for obesity are changing the shape of U.S. healthcare. From direct-to-consumer portals to pharmacy deals, how these drugs reach patients is changing—and leading to debates over pricing and coverage. Learn how your company can be both patient-forward while also maximizing revenue in this unique environment.
Beneath a field of loose rubble on Utah’s Mount Timpanogos, scientists mapped a hidden mass of ice up to 150 feet thick — enough frozen water to fill 600 Olympic swimming pools
Massive ice deposits hidden beneath Utah mountain rubble could reshape understanding of water resources and climate patterns in the American West.
Dolphins worked out massive rookie offensive lineman
The Miami Dolphins are always looking for more depth along their offensive line, which is why they brought in a rookie for a workout on Tuesday.
UConn Student Justin Fargo Went from Family iPhone-Fixer to Small Business Cybersecurity Champion
'There is a massive shortage of security professionals, and the opportunity for information security-related roles is only increasing'
Persona 6, Kingdom Hearts 4 spoilers may have emerged online amid massive achievements leak for unreleased games
An apparent Steam leak has resulted in a large number of achievement details for upcoming games appearing online.
Commissioners consider multi-million-dollar contract for inmate health care
MEMPHIS, Tenn. — Shelby County commissioners are considering a massive multi-million-dollar contract for inmate health care. The contract would bring in a new medical provider for the county&…
Kingdom Hearts 4's Disney Worlds May Have Been Revealed By Massive Steam Leak
The achievement database Exophase has listed achievements for several games, including some that haven't been announced
Baker Mayfield Cashes In Ahead of Browns Reunion
Former Cleveland Browns quarterback Baker Mayfield just cashed in with a massive payday. The post Baker Mayfield Cashes In Ahead of Browns Reunion appeared first on HEAVY.
49ers catch massive break for Week 1 battle vs. Rams
The 49ers are taking on the Rams in Week 1 of the 2026 season, but their division rivals won't have one of their best players for the matchup.
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
Texas’ Biggest Concern Going Into Saturday Is This
Texas has one of the most talented offenses in college football. But if the Longhorns want to finally beat Ohio State on Saturday night, they have to find a way to push the football down the field. That was a massive problem last year. Ohio State completely suffocated Texas’ passing game for most of its…
Women immigrant-owned businesses featured at massive market at HER Tel Aviv festival
“We really want to show the diversity and the connection and the love for Israel,” HER Tel Aviv founder and CEO Sivan Hadari said.
Russia launches massive, deadly, and ‘complex’ attack against Ukraine
Fighting between Ukraine and Russia commenced after a 72-hour pause for diplomatic visits to both countries by U.S. officials. Russia launched a massive attack on Ukraine on Tuesday, firing dozens of cruise missiles and over 140 drones as the war raged on after this weekend’s peace talks brokered by U.S. envoys Jared Kushner and Steve […]
Moment of Science: Abundant oxygen not enough to explain massive ancient insects, new study suggests
Unlocking answers about giant ancient insects! Here's why an abundance of oxygen 300 million years ago may not explain why some animals got so gigantic after all.
The Good, the Bad, the Ugly: Week 1
Through week one, we are already starting to have some clarity as to who the top teams in the Group of Six are. North Dakota State has looked dominant through two games, Boise State almost pulled off a massive upset against a National Championship contender, and the Air Force defense looks improved. It is certainly […]
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
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