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UW Health celebrating 60th anniversary of Transplant Center
For 60 years, some of the most critical and life-saving medical miracles in the world have happened in our backyard.
Rising energy costs have major impact on small business owners
For small business owners like Xavier Miranda of Top Florida Roofing out of Cutler Bay, Florida, rising energy costs have a multi-pronged impact.
A Gold Medal and a Breakthrough for Leipzig’s Young Stars
Elite prospects Mirja Kropp and Marie Kleemann secure landmark Fritz Walter Medals, cementing their status as the future of German football following a dominant U17 European Championship triumph.
Irvington data center poses health concerns for school community — and could also impact enrollment
Irvington Community Elementary in Indianapolis sits just north of the proposed DC Blox data center.
PODCAST: Lamont, Fazio trade blame over political corruption
WSHU's Ebong Udoma and CT Mirror's Mark Pazniokas discussed the governor candidates' recent focus on political corruption.
CT insurance department approves rate hikes for 2027 health plans
CT elected officials criticized the approved average rate hike of 11.3% for 2027 state-regulated, individual health plans.
Owen Heinecke: Don’t Let the Michigan Loss Divide Oklahoma
Frustrated fans demand accountability after a sloppy defeat in Ann Arbor, but the Sooners must mirror last season’s resilience to prevent a winnable loss from fracturing the locker room
Value of Things: In the rearview mirror
What was the good, bad, and ugly from Sunday’s 36-31 loss?
Twilight at Tanglewood fundraiser returns to Elmira in September
Tanglewood Nature Center will host its annual fundraiser in Elmira featuring local drinks, animal encounters and music.
MEX Exchange, Part of MultiBank Group, Expands Executive Team as International Growth Accelerates
DUBAI, United Arab Emirates--(BUSINESS WIRE)--Sep 14, 2026--
Helen Mirren ‘totally’ avoids doctors, prefers AI: ‘I just completely ignore everything’
Mirren spoke to EW about her aversion to medical care at the 2026 Toronto International Film Festival, where she supported her new thriller, “A Talent for Murder.”
Climate Science: Transitions often brings out creativity, new ideas and solutions
The United Arab Emirates Is sitting on an enormous pool of oil. They are also selling this oil to the market and making enormous amounts of money. However, they are
Nadiem Amiri takes responsibility after costly penalty miss against Frankfurt
Nadiem Amiri has taken responsibility for his missed penalty after Mainz fell to defeat against Eintracht Frankfurt.The midfielder had the chance to bring Mainz level from the spot, but failed to conv...
Electric bills, primary spending, CCSU president complaint: CT politics news
by CT Mirror Staff, CT Mirror September 11, 2026 These news briefs are part of The Connecticut Mirror’s 2026 political coverage. For more Connecticut political news, sign up here for The Issue, the…
Jays Lose To Orioles
Orioles 7 Jays 4 This one couldn’t have gone much worse. Dylan Beavers homered on the second pitch of the game. Then, in the bottom of the first, the Jays had two on and one out, and Vladimir Guerrero was picked off first—just bad baseball. With a runner on second, he wasn’t going anywhere. It […]
Electric bills, primary spending, CCSU complaint: CT politics news
Plus: the Blue Ribbon Commission is at work, a foster care prevention grant is awarded, and Lamont announces new Shore Line East trains.
Could Clowney Be Nets Most Improved Player in 2026-27?
With an elite foul-drawing rate and explosive statistical growth, the young forward is mirroring NBA superstars as he battles for a long-term future in Brooklyn’s rotation.
Rear Admiral Tim Gallaudet To Discuss “Marine Science & Technology Leadership In Turbulent Times” At St. Mary’s College
LEXINGTON PARK, Md. – The Patuxent Partnership and the Steny H. Hoyer Center for the Study of Democracy at St. Mary’s College of Maryland will present an evening with Rear Admiral Tim Gallaudet, Ph.D., USN (Ret.), on Wednesday, September 30, from 5:00-7:00 p.m. at the College’s Dodge Performing Arts Center. Gallaudet, former acting administrator of […]
Hampshire need miracle to avoid relegation
Hampshire cricket head coach Russell Domingo believes his side need "a bit of a miracle" if they are to remain a Division One side in the County Championship.
“Everyone has miracles”: OSU student turns childhood cancer journey into advocacy
As National Childhood Cancer Awareness Month begins this September, Oklahoma State University student Brooklyn Hawkins is using her childhood cancer journey and nonprofit to support children and families experiencing childhood
How Major League Baseball Anchored a Nation After 9/11
Major League Baseball has long mirrored the American psyche, but its role in the fall of 2001 transformed the sport from a national pastime into a key tool of national recovery. Following the September 11th terrorist attacks, which resulted in the tragic loss of about 3,000 lives, the country experienced an unprecedented halt in daily …
Rear Admiral Tim Gallaudet, PhD, USN (Ret.) to Discuss “Marine Science & Technology Leadership in Turbulent Times” at St. Mary’s College
The Patuxent Partnership and the Steny H. Hoyer Center for the Study of Democracy at St. Mary’s College of Maryland will present an evening with Rear Admiral. Tim Gallaudet, Ph.D., USN (Ret.), on Wednesday, Sept. 30, from 5-7 p.m. at the College’s Nancy R. and Norton T. Dodge Performing Arts Center.
Postpartum politics: What it means to run for government as a new mum
Victorian Greens candidates Nina Crawley and Lini Fernando reflect on their experiences running a political campaign just months after giving birth. From the challenges and compromises to the support networks that wrapped around them, and why showing up vulnerably in public space matters. Subscribe In 2024, when my second child was four months old, I decided to run for local government. Fast forward two years, I am again four months postpartum, with my third child, and this time running in the state election. But this time has hit differently. Going through pregnancy, birth and postpartum while being a political candidate has had a more profound and personal impact than I ever expected. I reached out to my fellow Greens candidate for the state election, Lini Fernando, who gave birth 20 days before me, and her experience closely mirrored mine. Postpartum has its own unique challenges that we’ve not seen reflected in stories about women running for office. When people discuss the “juggle”, they’re usually talking about the practical mechanics of looking after small children - childcare arrangements, pumping schedules and logistics. As mums of multiple children, we were both aware of the logistical changes and difficulties that accompany giving birth and the months after. We assumed that combining this with running for election would be hard, but that we could organise our way out of any problems. What neither of us anticipated was the intense vulnerability that comes with putting yourself into the spotlight of a state election campaign at a time when you are physically exhausted and navigating things like breastfeeding and feeling like a stranger in your own body. There have been challenges that neither of us anticipated. Firstly, needing to buy new clothes because the supportive leggings that are a staple of the postpartum wardrobe weren’t going to cut it for community events. Lini held her first fundraiser - a trivia night - just three weeks postpartum. A business-casual wardrobe, several sizes bigger than pre-baby, was needed, and fast. As women, how we look is closely scrutinised, and the internalised fatphobia is loud. We are conditioned from our earliest days to believe that our appearance is tied to our worth, and taught how we are allowed to show up in public. Women who dare to put themselves into the spotlight also receive more abuse than their male counterparts, including criticism of their appearance. To stand in front of members of your community and try to convince them that you’re the best person to represent them in parliament is a challenge in and of itself. To do it with leaking breasts, a pelvic floor that could betray you at the first sign of a sneeze, a body that still feels unfamiliar, and with half your hair falling out (hello postpartum hair loss!) is another thing altogether. It requires courage, allowing yourself the grace to be vulnerable in public, and the belief that showing up, however imperfectly, matters. And the vulnerability isn’t just physical; it also includes factors like having to ask a campaign team to accommodate the realities of having a baby. Asking for help is hard, and it’s a skill that both new parents and hopeful political candidates need to become comfortable with. Parents understand the disappointment that comes when a call for help or connection is rebuffed, like a friend cancelling a much-needed coffee. That rejection is amplified for political candidates calling dozens of people each week. Many people don’t realise running for Parliament, when you aren’t the incumbent, is a volunteer role supported largely by other volunteers who have to squeeze volunteering in around their paid work. Calls need to be made and meetings held after work hours - usually during “witching hour” (5-8 pm), that special time of night when babies cry for no reason. I found that I was struggling to make these commitments, or having to tap out and ask for them to be rearranged. When I spoke to Lini, we realised that she had had a similar experience, this push-pull of being the candidate and wanting to show our faces at meetings and help recruit new volunteers at ‘calling parties’, but also being the only people who could settle our newborns. Sometimes we could merge the two worlds; Lini and I realised that we had both attended 7:30pm meetings online, sitting in a dark room, struggling though breastfeeding and settling our babies. Although we’re both committed to breaking the stigma around breastfeeding, it can be hard to keep your composure while trying to feed a young baby as they try to latch, spew and fuss. Ultimately, Lini and I agreed that showing up vulnerably in public space matters. Leaders should possess empathy and understanding for those who feel raw and in transition; from the dad who just got evicted to the teen who acquired a disability - anyone who feels they aren’t the version of themselves they expected right now. The patriarchy tries to tell us otherwise, but women shouldn’t have to wait until they’re ‘recovered’, no longer vulnerable, before they feel entitled to participate in public life. In fact, we could all benefit from our leaders being a little more vulnerable. *This piece was cowritten, but has been presented in the first person for the sake of style. About the authors Nina Crawley is former teacher and community organiser who now works in human rights and inequality advocacy for a non-profit. She’s a mother of three keen to get back to running as soon as her pelvic floor allows! She’s contesting the seat of Ivanhoe for the Greens in this year’s state election. Lini Fernando is a lawyer working in diverse areas of law including anti corruption and public law. She’s a mother of two and a gardening and good policy enthusiast. She is currently contesting the seat of Croydon for the Greens in this year’s state election. Thanks for reading Cheek Media Co. ! This post is public so feel free to share it. Share
CAA: Soil Health Field Day continues Yampa Valley’s agricultural legacy
The Routt County Conservation District (RCCD) on July 25 hosted the 2026 Soil Health & Adaptive Grazing Field Day in North Routt. Fernando Falomir, a fifth-generation rancher from Chihuahua, Mexico, led the workshop. The event...
Exclusive | Tech, EV and aerospace execs likely to join Xi’s US trip to mirror Trump team
Sources say business leaders are expected to travel to Washington, but the plans may be ‘more about optics’ than concrete results.
Houston controller Chris Hollins could challenge Mayor John Whitmire
Hollins named Whitmire alongside officials he hopes to unseat, saying “The day for change is coming.”
Arsenal's ambition matching Arteta's vision as new deal nears
The perception of Arsenal's transfer window varies depending on who you speak to - but there will be no disagreement from anyone at Emirates Stadium over how crucial their next expected signing will be. With the market closed until January, the club are now in the process of finalising an agreement with manager Mikel Arteta over his protracted new contract. Arteta moved unequivocally last month to remove any lingering doubt over his future: "Everybody feels comfortable that the timing of the contract is not going to be an issue because my will certainly is to be here and I'm very happy here."
Experts examine ethical risks of using AI in public health
Artificial intelligence (AI) holds profound potential to reshape public health. Although its application accelerates threat detection and targeted interventions, the rapid deployment has outpaced the regulatory, validation, and equity safeguards standard to traditional health interventions.
Ella Langley leads Country Music Association Awards nods, with mentor Miranda Lambert close behind
Ella Langley leads the 2026 Country Music Association Awards nominations with nine nods, thanks to her hit “Choosin’ Texas.” | WWL
Messi sets up Inter Miami equalizer after early Lewandowski strike
Lionel Messi set up Casemiro's equalizer as Inter Miami earned a 1-1 draw against Chicago Fire despite Robert Lewandowski's early strike. Poland striker Lewandowski fired the hosts into a 10th-minute lead at Soldier Field as he volleyed in Andrew Gutman's cross from the left.
Illinois' Zvonimir Ivisic Gets Optimistic Injury Update From Assistant Coach
Illinois basketball's projected backup center got a key update from a Fighting Illini assistant coach.
Mikel Arteta Names Kevin De Bruyne Among Best Midfielders Ever
Mikel Arteta worked with Kevin De Bruyne for more than three years at Manchester City before taking charge of Arsenal, and remains a huge admirer of the Napoli midfielder.
iPhone 18 Pro is eSIM-Only in These Countries
Apple has been phasing out the SIM card tray on iPhones, with the latest models relying solely on eSIM technology in select countries. According to Apple, the iPhone 18 Pro and iPhone 18 Pro Max support eSIMs only in these countries and regions: Bahrain Canada Guam Japan Kuwait Mexico Oman Qatar Saudi Arabia United Arab Emirates United States U.S. Virgin Islands iPhone 17 Pro models are eSIM-only in the same countries, so there is no change this year.
How 9/11 Changed New York—And America
The attacks 25 years ago inspired a sense of national unity. It has since been shattered.
Former STC Dual Credit Student Joins Computer Science Faculty
Texas Border Business By Joey Gomez McALLEN, Texas – South Texas College’s newest Computer Information Technologies (CIT) faculty member, Ramiro Santos believes he has come full circle. Not long ago, Santos was a dual credit student from PSJA Southwest Early College High School, who turned to STC faculty for guidance as he discovered a passion for […]
Demirovic the star as Stuttgart stroll to victory vs Viking
On the club’s 133rd birthday, VfB Stuttgart returned to Champions League action on home soil, looking to start their campaign with three points against Norwegian champions Viking FK.Sebastian Hoene�...
Christian singer-songwriter to perform in Hershey: Here’s how to get tickets
The “God of Miracles” singer-songwriter will be at the Giant Center in Hershey in April.
Dear Abby | Senior women's admirer lacks courage to confess
Dear Abby: I'm in love with an older woman. I'm 41, and she is about 35 years older. I have known her since I was a kid. She's the reason
Stark contrast with McLeish shows Robinson's Dons identity crisis
On Saturday, before his team's top-of-the-table clash with Celtic, I asked St Mirren manager Craig McLeish how easy it has been to implement the style of football that is enthralling the Paisley club's supporters amid their then unbeaten start to the league season. The man who led the Saints youth team under Aberdeen boss Stephen Robinson has produced a side that plays an exciting, fast-paced brand of football with a clear identity already. Eight new signings started the narrow defeat to the champions as well as Fraser Taylor, who was on loan at Partick Thistle last season.
NiteShyft Announces October Launch of AI Business Operating Platform for Small Companies
NiteShyft will open its AI business operating platform to the public in October 2026, following private testing in which AI agents completed more than 2,000 business tasks at a median speed 736 times faster than benchmark estimates, according to company records.Dubai, United Arab Emirates--(Newsfile Corp. - September 8, 2026) - NiteShyft today announced that its business operating platform will open to the public in October 2026, following a private testing period in which the platform executed.
COVID-19 cases on the rise across all age groups, local healthcare expert says
Dr. Jason Bowling, the chief epidemiologist at University Health, said there is an increase in COVID-19 cases across all age groups.
18 Sports Commentary – the first day of the school year
ELMIRA, N.Y. (WETM) – It’s time for another special 18 Sport Commentary. On this edition, we discuss the very first day of school in the New York region of The Southern Tier. The first day of school symbolizes much more than just being the first day to go back to the classroom. It’s symbolic of […]
18 Sports Plays of the Week
ELMIRA, N.Y. (WETM) – It’s time for the next edition of the 18 Sports Plays of the Week. (Video Courtesy: Rochester Aquinas and Wellsboro Hornets Hudl, Chris Wilcox) The 18 Sports team showcases the top plays from the past week in the Twin Tiers. Top honors this week include 5 major moments on the high school […]
MAC Challenges Michigan Win, Big Ten Fires Back
The Big Ten has responded after the MAC accused its replay crew of failing to follow proper protocol during Michigan’s miracle win over Western Michigan.
Exclusive: Two of gaming’s biggest names are making a big investment in gaming’s future
The first thing to know about the Nova Games Foundation is that it isn’t about The Game Awards. And it’s not about PlayStation. The ambitious new grant program is the brainchild of Geoff Keighley and Mark Cerny. Keighley is the host of The Game Awards, Summer Game Fest and Opening Night Live. Cerny is a game designer of some 45 years and the lead architect for the PlayStation 4 and 5. But this new thing, which they’re revealing through Game File, isn’t about their day jobs. It’s an unaffiliated, standalone philanthropic project. It’s a bet on the artistic future of video games and a way, they tell me, to give back. “I’m nearing the end of my career,” Cerny recently told me over email. “I’m not done yet, but paying it forward—in the best way possible—is very much on my mind these days,” The Nova Games Foundation is a university-affiliated fellowship program, intended to offer six-figure grants to 20 young game designers each year, potentially for decades to come. It will offer no-strings-attached funding along with mentorship from games industry leaders, a combination intended to aid the development of groundbreaking new games, Cerny and Keighley told me. Nova will begin accepting applications in December, from class of 2026 and 2027 students from 13 affiliated gaming programs at universities in eight countries. The schools working with Nova include the New York University and the University of Southern California in the U.S., along with Abertay University in Scotland, Cnam-Enjmin in France, TH Köln in Germany, and the Royal Melbourne Institute of Technology in Australia, Cerny and Keighley said. The plan: $100,000 per recipient, with about a quarter of Nova fellows eligible for up to $500,000 more for projects that are shaping up particularly well. Payments will be delivered based on development milestones, and recipients will own their games. Nova will help promote the work, and developers will be free to pursue the publishers and platforms of their choice. Nova can help introduce fellows to publishers, but won’t take a cut. “I’ve always wanted to give back, but given my role in the industry, I’ve never felt it appropriate to commercially invest in games,” Keighley told Game File. “I’ve never owned stock in a game company or taken a financial stake in a game. Nova is philanthropy: we aren’t taking equity or looking to recoup the grants. The return we’re hoping for is creative—helping new voices make games and find their footing. “Mark and I have each made multi-million-dollar donations to establish the foundation, and we intend to keep contributing. We hope others will join us.” Cerny and Keighley have already hired an executive director, John Maconga, and a head of grants, recent Game Developers Conference director Ashley Corrigan, to help launch the effort. They’re working to recruit game industry leaders to join the effort. Keighley says “dozens of leading game directors have already expressed interest in contributing their time.” To name one, they’ve already gotten Josef Fares, lead designer from It Takes Two and Spit Fiction studio Hazelight on board with a donation and pledge to help out. “I’m proud to support Nova because it gives the next generation of creators the freedom to explore their creativity and hopefully bring their unique visions to life,” Fares told Game File. A plan forged from a friendship Keighley and Cerny have known each other a long time. It’s been so long, Cerny isn’t even sure exactly when they met. “We travel in much the same circles and I’m sure first intersected in the 90s or early 2000s,“ Cerny said. Keighley thinks it might have been during his stint writing a column about the mid-’90s console 3DO for a gaming magazine while Cerny was working on games with Crystal Dynamics or on Way of the Warrior with Naughty Dog. They became genuine friends about a 10 years ago, Keighley said, as they bonded over a shared love of games and a hope to improve the industry. “About a decade ago, we started having dinner a few times a year in LA,” Keighley said. “Just to catch up on life and the industry. Those conversations continued over Zoom during COVID. Nova grew out of that friendship and a question we kept coming back to: ‘What could we do to help the next generation of game directors get started?’” Keighley credits Cerny with the idea to figure out a way to put their money and time back into the industry. At one of those dinners, Keighley proposed the idea of a fellowship program. He’d recalled applying for a Rhodes Scholarship when he was younger. “Spoiler: I didn’t get it,” he said. He’d admired the MacArthur Foundation’s so-called “genius grants.” He liked these kinds of programs that recognized people’s talents and gave them the financial boost and the freedom to realize their potential. With Cerny, he had pondered what a game industry version of that could be. Keighley liked the idea of centering the fellowship on students, drawing inspiration from the accomplishments of Jenova Chen, the USC game design graduate who went on to lead the creation of gently moving, ambitious games such as Flower and Journey. Keighley also thought it could be useful to help promising graduates bridge the transition from student to professional. “Joining an established studio isn’t always possible—especially in today’s market—and even then, it isn’t the right path for everyone,” Keighley said. A fellowship, he realized, could give “graduates the time, resources and guidance to pursue a game of their own and not worry about the commercial viability.” As the idea took shape, Cerny also saw an opportunity to enable more games of a certain type: “The target with the grants is games as an artistic medium,” Cerny told me. “We like to say games with ‘artistic, literary and societal value.’” He added: “I’m a pretty big gamer myself, though I tend to gravitate towards the smaller and more unique or artistic titles, games like Neva, Abzu, Gorogoa, Stray or Outer Wilds. I was just playing and Roger on a flight to Japan, and was getting misty eyed to a degree that I was concerned that a flight attendant would ask me if I was OK. “So one fun benefit here is the games that will come out of the Nova Games Foundation – I can’t wait to play them myself.” Cerny believes it will also be useful for Nova fellows to hone their craft and team leadership skills. “We are looking for the next generation of visionaries,” he said. “The trick is that they will also need to have the executive function necessary to drive a small project to completion.” Game File is a reader-supported publication. To receive new posts and support my reporting, please consider becoming a free or paid subscriber. Subscribe Going big with this Keighley and Cerny may have started Nova and may be the ones primarily backing it right now, but they’re dreaming of something that goes beyond them. “Mark and I may have helped get it started, but one of our measures of success is that Nova grows into something the entire games industry feels a sense of ownership in,” Keighley said. “Our ambition is to build a lasting endowment supported by people and companies across the industry, and an equally broad community of creators willing to give their time and experience to the next generation.” The industry has a lot of knowledge that it can pass to the next generation, Keighley said: “Nova can hopefully become a way to connect that generosity with talented young creators at the moment when it can make the biggest difference.” Cerny, who told me he believes Nova can mature “over the next 10 or 20 years,” sees an opportunity to give generations of game makers momentum. “The industry has changed immeasurably since I started in games in 1982,” he said. “These graduates have talent, training and tools that outclass what we had back in the day by an astonishing amount. But they face a tough road ahead getting traction in the industry, and many could benefit from our support. We want to be there to give it to them.” “There’s a personal side to this, too,” Keighley said. “I don’t have children, and I’ve spent a lot of time thinking about what I can do for future generations. Games have been my entire career. I’ve been incredibly fortunate, and helping someone else build a life in this industry feels like a meaningful way to give back.” Cerny’s oeuvre dates back to Marble Madness and Sonic the Hedgehog 2. He has stood on stage multiple times to reveal the future of PlayStation hardware. He’s been an executive producer for a string of modern PlayStation classics such as The Last Guardian and Marvel’s Spider-Man. Nevertheless, of Nova, he said, “It’s certainly not like anything I’ve done before.” Nova Foundation applications will be due in December and the first wave of fellows will be announced in March 2027. A full list of participating universities and steps students and recent graduates can take to apply to become a Nova Fellow is forthcoming.
Future Leader: Haven Banks, Director of Marketing & Outreach, MiraSol Health
Haven Banks, Director of Marketing & Outreach at MiraSol Health, has been named to the Future Leaders Awards Class of 2026 by Hospice News. To become
Tuesday Morning Politics: State of Iran War; Home Stretch to Midterms
Jonathan Lemire, co-host of Morning Joe on MS NOW, writer for MS NOW and staff writer for The Atlantic, talks about the latest developments in national politics.
Names in the News 9-8-26
Appointments and promotions at Constellation Hotels, Emirates, Virgin Atlantic and Hilton
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD
With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.
Donald Trump threatens to halt Canadian Bombardier sales to US
Cheryl Cassoni reports on President Trump's threat to halt Canadian airplane maker Bombardier's sales to the US. Vogel Group's Samir Kapadia analyzes the trade pressure campaign and its political stakes in battleground states.
Canadian teens still rank among the world's best in reading, math and science — but scores are slipping. Here's why
Canada's decline in 2025 mirrors a global downward trend, according to the latest findings from the Organisation for Economic Co-operation and Development.
Alonso thought 'outside the box' against Arsenal
BBC Radio 5 Live's Monday Night Club team have been discussing Chelsea boss Xabi Alonso's "brave" and "fascinating" approach to defending Arsenal's corners. The Spaniard suffered his first defeat as Blues manager on Sunday, as Mikel Arteta's side came from behind to earn a 2-1 win at Emirates Stadium. On Sunday, Chelsea employed a tactic of leaving four players upfield for defensive corners, going man for man in the penalty area.
30 years after her death, Gilda embodies Argentina’s enduring faith in folk saints
Thirty years after Argentine cumbia star Gilda died in a tour bus crash, the beloved singer has become something more to many fans: a miracle-working folk saint.
Michigan QB Depth Chart: Who is Bryce Underwood’s Backup?
Michigan Wolverines quarterback Bryce Underwood pulled off a miracle Saturday night against Western Michigan. Fans know the story by now. Underwood threw a Hail Mary pass out of bounds that seemed to give WMU the upset win, only for the officials to put one second back on the clock. The next pass was on target […] The post Michigan QB Depth Chart: Who is Bryce Underwood’s Backup? appeared first on HEAVY.
Brian’s Business Beat: New businesses open, restaurants progress in New Bern area
Several New Bern-area businesses and city projects are moving forward, according to a Labor Day edition of Brian’s Business Beat.Atlantic Glass & MirrorAtlantic
Washington Nationals Tie MLB Blown Save Record
The Washington Nationals will now look to pull off a miracle over the final 17 regular season games to not own the MLB's blown save record
Within days of the January 2025 inauguration, more than 3,000 taxpayer-funded federal data sets from the CDC, the Justice Department and the Office of Personnel Management were pulled offline, and Harvard public health researchers held marathon sessions scraping the pages before they vanished
Within days of the January 2025 inauguration, thousands of federal datasets began disappearing from public websites. Researchers scrambled to mirror the pages before they vanished — and much of what was captured cannot fully replace what was lost.
Odegaard back to his 'very best' for Arsenal
It is surely too early in the season to get carried away, and there are likely to be bigger tests ahead for Mikel Arteta's side. Against Chelsea, they had to find a different way to win after £117m signing Morgan Rogers fired the visitors into a second-minute lead at Emirates Stadium on Sunday. Former Manchester United and England player Ashley Young said Odegaard's form will be key for Arsenal this season.
Mikel Arteta Issues Cristhian Mosquera Injury Update After Chelsea Win
Cristhian Mosquera was missing as Arsenal beat Chelsea at the Emirates, with Mikel Arteta confirming the defender is dealing with a muscular problem.
Jaguars Have 21st-Hardest Strength of Schedule in 2026
Coming off an eight-game winning streak, Jacksonville looks to capitalize on a favorable slate while Trevor Lawrence mirrors a high-octane offense featuring deep threat Brian Thomas Jr.
That Was Less Than Fun, Jays Lose
Jays 1 Royals 6 This one, well, it was a great game to watch. Right from the first inning. Brett Bateman was hit by a pitch to start the game, but Nathan Lukes hit into a double play, and Vladimir Guerrero grounded out. And the bottom of the inning went single (roller down the first […]
Mikel Arteta hails Arsenal’s display in win against Chelsea
Mikel Arteta hailed a “beautiful” win after Arsenal came from behind to beat Chelsea 2-1 at the Emirates Stadium. The Premier League champions required a response after conceding for the first time this season, Morgan Rogers stunning home fans into silence with a volleyed goal after 77 seconds before the hosts hit back against a Chelsea side still finding its feet under Xabi Alonso.
What Michigan Must Fix Before Facing Oklahoma
Michigan got a miracle win against MAC opponent Western Michigan in week one and now must prepare for a daunting task as Oklahoma comes to town for week two.
Arsenal v Chelsea teams announced
Arsenal welcome Chelsea to the Emirates on Sunday and we now know how the two teams will line up.Photo by Alex Pantling/Getty ImagesArsenal starting XI: Raya, White, Konsa, Gabriel, Calafiori, Rice, L...
Kyle Whittingham Blasts Michigan Performance Despite Miracle Win
Kyle Whittingham called Michigan’s 13-12 escape against Western Michigan “nothing short of a miracle” and outlined major concerns afterward.
Predicted XI: Xabi Alonso’s favourite team is clear
Chelsea are preparing to take on Arsenal at the Emirates, and we’re really curious to see who Xabi Alonso picks to start the game.If you enjoy Talk Chelsea coverage and want to see more of it, add u...
MAC Commissioner Responds to Big Ten Explanation in Michigan Miracle vs. WMU
MAC commissioner Jon Steinbrecher says the Big Ten provided video and audio confirming its explanation for restoring one second before Michigan’s game-winning Hail Mary.
How much will Celtic miss Asian Games-bound Yang?
Yang Hyun-jun illustrated his importance to Celtic with a vital goal against St Mirren before heading off for the Asian Games.
Arsenal v Chelsea: Team News, Predicted Lineup and Score Prediction
Arsenal welcome Chelsea to Emirates Stadium on Sunday afternoon with both teams looking to maintain their perfect start to the Premier League season.After two wins from two, Mikel Arteta now has some ...
Arsenal v Chelsea Match Preview: Huge London Derby at the Emirates
Arsenal return to Emirates Stadium on Sunday looking to make it three Premier League wins from three when Chelsea arrive for a huge London derby.Mikel Arteta’s side followed their opening victory wi...
Sequence of JJ Buchanan's Michigan Miracle touchdown catch
JJ Buchanan made an incredible catch of a Bryce Underwood pass with no time left to save Michigan from a stunning upset by Western Michigan.
Arsenal vs Chelsea – Predicted lineup and team news
Arsenal sit third in the Premier League table heading into Sunday’s derby with Chelsea, with a win at the Emirates Stadium the chance to close the gap on the teams above them. Mikel Arteta’s side ...
Chelsea XI vs Arsenal – Predicted lineup and team news
Chelsea sit fourth in the Premier League table heading into Sunday’s trip to the Emirates Stadium, with a win over Arsenal the chance to move above their hosts. Xabi Alonso’s side have scored 12 g...
Michigan football stuns WMU with miracle Hail Mary after game seemed over
Michigan football opened its 2026 season with a stunning Hail Mary to beat Western Michigan. Here's who stood out.
The Surprising Thing That Motivates Men to Lose Weight More Than Health
Men in focus groups downplayed body image concerns, then described avoiding photos, hating mirrors, and wanting to fit into old clothes again.
Manager delighted with another Premiership win
It was a tough top-of-the table clash in Paisley between Celtic and St Mirren, and it was the league leaders who went home with all three points thanks to a 2-1 victory.Goals from Liam Scales and Yang...
‘Full House’ creator recalls ‘miraculous’ on-set moment with 1-year-old twins Mary-Kate and Ashley Olsen
‘Full House’ creator Jeff Franklin detailed the impressive acting Mary-Kate and Ashley Olsen were doing during the first season of the sitcom.
“Full House” creator recalls ‘miraculous’ on-set moment with 1-year-old twins Mary-Kate and Ashley Olsen: ‘How is this possible?’
Jeff Franklin detailed the impressive acting that the child stars were doing during the first season of the sitcom.
Celtic Fans Furious With What Referee Did vs St Mirren
Celtic were able to come out with a win against St Mirren away from home but the fans were not happy with what the referee did on the night.
Squad list for Bologna vs. Sassuolo
Domenico Tedesco has named the following squad for tomorrow’s match:Goalkeepers: Happonen, Pessina, Skorupski.Defenders: De Silvestri, Heggem, Helland, Holm, Miranda, Rahim, Theate, Vitik, Zortea.Mi...
Natalie Portman welcomes third child, her first with Tanguy Destable
The “Black Swan” actress previously shared that it was “such a privilege and a miracle” to have another child.
Celtic starting XI for Premiership clash with St Mirren
It’s Saturday night league action for Celtic as they head to Paisley to take on St Mirren in a top-of-the-table Premiership clash.Martin O’Neill’s side are the only team in the league with a 100...
FC Twente chief responds to Barcelona interest in Ruud Nijstad
The teenager has plenty of admirers.
Arsenal v Chelsea: Key stats and talking points
Arsenal and Chelsea meet on Saturday having each won both of their opening matches. BBC Sport examines some of the key themes ahead of Sunday's meeting at Emirates Stadium (16:30 BST). Arsenal will aim to continue a strong start to their title defence by winning their opening three Premier League matches for only the second time in the past 21 seasons.
Reform UK winded by donations row as insiders call for shift in approach
Nigel Farage's admirers in the party are calling for a stronger operation as the party aims for power.
Watch Arteta pre-Chelsea and Slegers pre-Brighton press conferences
Arsenal Women begin their FA WSL campaign against Brighton on Sunday before Chelsea visit the Emirates to face the men’s side.Watch Arteta pre-Chelsea and Slegers pre-Brighton press conferences 3Ars...
Alcaraz knows health a big part of his success
NEW YORK — Feeling better than he expected after a four-month absence, Carlos Alcaraz is planning to take more breaks during the tennis season. Alcaraz returned to play at the U.S. Open after being sidelined since April by a right wrist injury. The defending champion advanced to the fourth round Friday with a 6-3, 6-4, […]
2 South Florida men sentenced in $34.8M health care fraud conspiracy, DOJ says
According to the U.S. Department of Justice, Kenneth Charles Kessler III, a Miami man, and Michael Andrew Gomez, a Miramar man, pleaded guilty to one count of conspiracy to commit health care fraud.
Puerto Rico water crisis, youth marketing campaign: CT politics news
Plus: CT commemorates International Overdose Remembrance Day, new cancer treatment arrives, and officials highlight local Latino businesses.
Celtic Confirm Bad News for Game Against St Mirren
Martin O'Neill has confirmed some bad news for Celtic heading into their game against St Mirren.
Bloom Healthcare Acquires Christian Care House Calls
Colorado-based Bloom Healthcare has acquired Christian Care House Calls, which provides home-based senior primary care in Texas. The deal expands the
Nuclear medicine physician-scientist Dr. Amir Iravani joins UCLA Health to lead Theranostics Program
Dr. Amir Iravani will serve as director of the Theranostics Program and vice chair of clinical research in the department of nuclear medicine and theranostics.
CT offers mental health resources for kids. Here's what to know
CT officials are launching a campaign to raise awareness about urgent crisis centers, which provide emergency mental health services to youth.
Why dogs tilt their heads, according to science
Dogs have developed the ability to parse human speech in ways that mirror our own.
Emirates gives premium economy seats a new feature: privacy screens
Until now, premium economy passengers have typically had little to separate them from their neighbors. Emirates wants to change that.
Arsenal brace for Chelsea test as Spurs seek spark
Something has to give when Arsenal host Chelsea in the Premier League this weekend, with both teams putting their 100 percent records on the line, while Tottenham are desperate to stop the rot.Recent history is against Chelsea, who are winless in nine Premier League games against Arsenal ahead of Sunday's clash at the Emirates.
Thursday Jays Notes
There isn’t much for Jays news this morning. The starters against the Royals: And, our weekly Anthony Santander rumour: Today’s lineups: Today’s Lineups BLUE JAYS GUARDIANS Brett Bateman – CF Steven Kwan – CF Nathan Lukes – RF Chase DeLauter – RF Vladimir Guerrero – 1B Jose Ramirez – DH Jesus Sanchez – LF Jo […]
Nuclear medicine physician-scientist Dr. Amir Iravani joins UCLA Health to lead Theranostics Program
Iravani will help advance the integration of theranostics into cancer care, expand clinical trials and research opportunities and develop new collaborations.
Opinion: We are one rainstorm away from another public health crisis
New England’s infrastructure cannot handle more intense rainfall that overwhelms systems designed decades ago.