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THC medication made PTSD nightmares disappear for more than a third of patients
A prescription form of THC helped many people with PTSD escape recurring trauma-related nightmares, with more than one-third reporting that the nightmares disappeared completely after ten weeks. The results could point toward a long-awaited treatment for one of PTSD’s most distressing and stubborn symptoms.
Bangladesh’s Ousted Leader Says She’ll Return Despite Threats
Bangladesh’s ousted leader Sheikh Hasina vowed to return to her country despite facing a death sentence, calling it her “duty” to help rescue a country she described as sliding into economic distress and democratic decline.
The Beauty Of Settled Science
Commenters convinced me I made a subtle mis-step in my framing of Psychology Research Is Mostly Fine. My framing emphasized that social priming studies had failed to replicate, but that many other subfields of psychology hadn’t. This naturally led commenters to point to failed replications in other subfields. Although none of these were as bad as social priming, few or none were entirely problem-free. Instead of emphasizing the difference between social priming and other subfields, I should have emphasized the difference between settled science and novel research. Here are some of my favorite psychology findings: The brain is sculpted by reinforcement learning, and a key driver of this learning is a prediction-error-based algorithm located in the nucleus accumbens and implemented through dopamine. Psychedelic drugs exert their effects through 5-HT2A receptors, pointing to a role for these receptors in some sort of construct like the balance between priors and new evidence. Certain cognitive functions are localized to certain brain areas (for example, impulse control to the frontal lobes; linguistic structure to Broca’s area, linguistic meaning to Wernicke’s area. But injure one of these areas, or render a certain function useless (eg a blind person having no more use for their visual cortex), and these mappings can gradually shift - suggesting that neurons are general-purpose compute whose specialization is a contingent fact about convenience and efficiency rather than a necessity. Most personality traits and general capabilities are about 50% genetic and 50% random, with little role for family environment or childhood history, with a few notable exceptions like partisan preference. Recent research complicates this story, but the further you go from this basic picture, the gnarlier the chains of indirect causation you require. Neurons fire together in “brain waves”, whose exact frequency corresponds with the character of consciousness; These divide neurons into natural subpopulations and linked graphs. The gamma rhythm corresponds surprisingly well to items in conscious awareness. GABA receptors seem to be involved in something like relaxation. By hitting different GABA receptors in different ways, you can modulate the exact type of relaxation you produce. Hitting GABA-A directly is too powerful and can cause dangerous levels of sedation, but allosteric modulation of GABA is an incredibly fruitful strategy that underlies drugs from benzos to barbituates to alcohol. If you know your GABA-A subunits, you can target specific subtypes of relaxation; for example, Ambien hits GABA-A1 and induces sleep. Memory divides somewhat fuzzily into bins of immediate-sensory, short-term, and long-term, with separate retrieval and storage functions, and separate systems for declarative vs. procedural learning. These can be harmed selectively, usually by hippocampal injury, so that some patients can remember their life stories but not form new long-term memories, or learn new skills like bike-riding but not new facts. The exact substrate of memory is unclear but seems to involve new synaptic connections between neurons in at least some way. The ability of modern psychology and psychiatry to treat mental illness is real but limited. SSRIs work for half or slightly fewer than half of patients; antipsychotics work with extreme side effects; benzodiazpines work but produce addiction and tolerance in many (not all) people. Most supplements are stuck in Poor Quality Study Replication Crisis Hell, but melatonin and l-theanine stand out as especially promising. Psychotherapy works with moderate effect size, but (with a few exceptions) seems to be more about the relationship with the provider than the details of the therapy itself. Mental hospitalization can sometimes defuse immediate crises but work less well than mental hospitals would like, with some studies showing overall negative effects. Schizophrenia is mostly genetic, but risk also increases with prenatal infection (especially rubella) and obstetric complications; there is suggestive evidence for roles of social stress and drug use (with psychedelics and marijuana making things worse, and nicotine if anything making things better). Bipolar and schizophrenia are so closely linked on a pathophysiological level that it seems like they might be the same disease; on the clinical level, they do seem to follow two separate courses/prognoses but can sometimes surprise clinicians by eg someone who seemed condemned to permanent schizophrenia unexpectedly recovering. The brain’s native reinforcement learning algorithms cash out in the phenomena of classical and operant conditioning; different reinforcement schedules reinforce at different levels, which can be exploited by bad actors to make especially compelling products (eg slot machines). None of these are immune to doubt. A few are speculative; one or two are genuinely unorthodox. But they’re all a step above one p = 0.049 paper that might not replicate. If they get overturned, they’ll be overturned by the same sort of genuine scientific shift that replaced Ptolemy with Copernicus or Lamarck with Darwin, not some sort of sordid discovery about someone entering random numbers into a spreadsheet. In 2008, Eliezer Yudkowsky wrote about The Beauty Of Settled Science: If you only care about scientific issues that are controversial, you will end up with a head stuffed full of garbage. The media thinks that only the cutting edge of science is worth reporting on. How often do you see headlines like “General Relativity still governing planetary orbits” or “Phlogiston theory remains false”? So, by the time anything is solid science, it is no longer a breaking headline. “Newsworthy” science is often based on the thinnest of evidence and wrong half the time—if it were not on the uttermost fringes of the scientific frontier, it would not be breaking news. Scientific controversies are problems so difficult that even people who’ve spent years mastering the field can still fool themselves. That’s what makes for the heated arguments that attract all the media attention. Worse, if you aren’t in the field and part of the game, controversies aren’t even fun. Don’t be embarrassed to read elementary science textbooks, either. If you want to pretend to be sophisticated, go find a play to sneer at. If you just want to have fun, remember that simplicity is at the core of scientific beauty [...] A steady diet of science news is bad for you: You are what you eat, and if you eat only science reporting on fluid situations, without a solid textbook now and then, your brain will turn to liquid. Psychology isn’t centrally the new paper in Annals Of Recently-Breaking News saying that an n=5 study showing that large portion sizes increase support for terrorism. Psychology is centrally ideas like brain waves, GABA receptors, reinforcement learning, twin studies, and connectionism. People who think differently are worrying too much about BREAKING NEWS!!!, and should stop. The key distinction isn’t “recent research in social psychology” vs. “recent research in cognitive/bio/behavioral psychology”, as my essay last week unfortunately implied. It’s recent research in general vs. the deposit of settled science, battle-tested hypotheses, and carefully-earmarked speculation. And part of the reason social priming in particular was such a disaster was that it defied that heuristic, building itself up over hundreds of studies until it approached or even entered the pantheon of settled science - before collapsing (5-HTTLPR was also sort of like this). This isn’t a claim that settled science is always right - Freud was “settled science” for a long time - just that there’s an intuitive distinction between the level of credence you should have in the existence of power posing vs. the existence of Broca’s Area. (I compounded this error by calling the last post “Psychology Research Is Mostly Fine”, which suggested I was talking about the new research rather than the settled science. I actually meant to distinguish between research-psychology-the-field vs. clinical-psychology-aka-therapy, but this framing unintentionally pushed against the point I wanted to make) Some commenters on the previous article understood this point, but challenged its weight. It’s very cool, they said, to know how many neurons are in which brain lobe, but the main way that Psychology affected their lives was through bad clickbait studies used to buttress dumb policies; some p = 0.049 study says that exposure to microaggressions makes minorities’ brains shrivel into raisins, and now their company has to implement punitive DEI or be sued for hazardous work conditions. I won’t dispute this as an accurate description of how the sausage gets made, but it’s worth examining the trains of thought that connect this observation to a campaign against psychology in general: The dumb woke psychology was wrong and bad, and I don’t have good heuristics for distinguishing dumb woke psychology from other psychology, so I’m going to assume it’s all wrong and bad. The dumb woke psychology was wrong and bad; it seems useful to punish/discredit psychology as a whole to assist my campaign against it, so for propaganda purposes I will try to discredit psychology as a whole. To people in the first camp, my response is: come on, your heuristics aren’t that bad. “Microaggressions makes minorities’ brains shrivel up like raisins” is in the woke category; “the hippocampal theta rhythm seems to be associated with both memory and pathfinding, suggesting an unexpected yet surprisingly compelling relationship between the two” is in the not-woke category, don’t play dumb here. To people in the second camp, my response is: deliberately exaggerated propaganda campaigns are bad and this is a confession, not an excuse. Inability to view science through anything but a political lens was what got us into this problem; doubling down on it is a temporary solution but a recipe for permanent disaster. If you pronounce entire fields of science to be acceptable collateral damage in your campaign against bad political actors, you will alienate not just scientists but patients, clinicians, and general lovers of truth. Instead, you can say the thing you mean - that woke partisans shouldn’t try to occupy and exploit the otherwise-noble science of psychology for their own political gain - and wage the same campaign with a halo rather than a comic-book-villain goatee. From the font of oracular wisdom that is Weird Sun Twitter: [ Vessel Of Spirit@VesselOfSpirit i love you all conditionally but i love the good part of you unconditionally. even if it becomes a very small part 2:11 AM · Jan 22, 2015 1 Reply · 5 Reposts · 29 Likes ](https://x.com/VesselOfSpirit/status/558084551772471298) This is how I feel about psychology1, too, but with a touch more optimism. The good part of psychology is enormous, a hoard of endless treasures. You just have to look past the headlines! 1 To play devil’s advocate - should one always be so magnamious? Astrology? Phrenology? These seem different in that their entire orientation was flawed from the start; they didn’t simply fail to find the correct constellation-personality connections, the whole project of searching for connections between constellations and personality was doomed from the start. More difficult might be asking the same question about education research, which is notoriously bad. I don’t know enough about education research to know if there’s some settled science of correct and enlightening results lurking in the background beyond the day-to-day froth of poorly-conducted and politically-motivated studies. I think if it’s 90% bad, 10% good, it’s correct to call it bad as a compact way of communicating a useful truth; I think psychology is better than that, but admit it’s a tough judgment call.
Super El Niño may push an already stressed climate ecosystem across a critical threshold, climate change researcher says
Live Science spoke with climate change researcher Jong-Seong Kug about how a super El Niño could cause lasting damage to our world.
Mental health can shape heart health outcomes
Research shows depression, anxiety and chronic stress can affect heart health. Discover the connection and how whole-person care can improve health outcomes.
Upcoming Science Cafe
BAR HARBOR—Join us for a fascinating Science Cafe with environmental toxicologist Nishad Jayasundara, Ph.D., as he explores how everyday contaminants and other stressors such as heat exposure may be quietly influencing kidney health. Chronic kidney disease (CKD) affects nearly 1 in 7 adults in the United States—and more than 840 million people worldwide. While factors like diet and genetics are well known, scientists are increasingly uncovering another important piece of the puzzle: environmental exposure. Drawing on his team’s research, Dr. Jayasundara, Maine INBRE alum as a College of the Atlantic undergraduate student and past MDI Bio Lab Visiting Scientist, will share how early-life exposure to environmental toxins can disrupt kidney development, and may affect kidney structure and function in adults. Blending cutting-edge research with real-world relevance, this Science Cafe will shed light on an important and often overlooked contributor to human health—and what it could mean for communities around the world. Monday, August 17, 2026 at 5 p.m.Hybrid event at Maren Auditorium and via Zoom Register Now What Are Science Cafes? MDI Bio Lab’s Science Cafes provide an informal introduction to ground-breaking biomedical research by its scientists, scholars from near and far and from local experts in other fields as well. Each Cafe lasts about one hour; the floor is open for questions and discussion. It can get lively and it’s always engaging. MDI Science Cafes are open to the public and free of charge. For more information, or to watch past events, visit our website. The MDI Science Cafe Series is brought to you by Cross Insurance. Subscribe Share Leave a comment
Entrepreneur who started business has regrets about work-life balance
The freedom of self-employment came with the motherhood cost I never saw coming. Instead of more flexibility, I got more stress.
Healthcare costs have more than doubled for many farmers this year, on top of soaring expenses
When Congress allowed Affordable Care Act tax credits to lapse, healthcare premiums spiked for millions of Americans — especially self-employed farmers and ranchers. That added cost is multiplying the stress on their already stretched balance sheets.
Chile declares health alert for hantavirus
The Chile Ministry of Health issued a Health Alert for hantavirus and other diseases, such as some arboviruses and avian influenza. This is the first time this measure has been taken and it will be in effect until July 31, 2027 and it extends from the Atacama region to the Magallanes region. “Hantavirus causes a disease that is endemic to Chile, transmitted by the long-tailed pygmy rice rat that lives in rural and semi-rural areas throughout almost the entire country. As a ministry, we are constantly monitoring its behavior and are very concerned and actively working because this year the virus's lethality has increased, and for this reason, we decided to declare this alert. As of last week, there were 46 confirmed cases and 18 deaths, representing a 39% lethality rate,” reported the Undersecretary of Public Health, Dr. Alejandra Pizarro. Cases have occurred in the regions of Valparaíso, Metropolitan, O'Higgins, Maule, Ñuble, Biobío, La Araucanía, Los Ríos, Los Lagos, and Aysén. By comparison, in 2025, there were 44 infections and eight deaths (18% case fatality rate). The health alert, which is preventative and prepared, will allow for the granting of extraordinary powers in the event of serious health emergencies to strengthen surveillance, ensure timely resource management, hire specialized personnel, implement health control measures, and expedite the acquisition of supplies through direct procurement. The alert does not imply that there is an ongoing epidemic or that the healthcare system is overwhelmed. Subscribe to Outbreak News TV on YouTube “Hantavirus is not exclusively a summer virus, as the long-tailed pygmy rice rat is present year-round. Therefore, we urge everyone to take extreme precautions: avoid touching rodents, ventilate homes before entering if they have been closed, clean unused spaces with water and bleach, and keep garbage covered and food stored away. Furthermore, it is crucial to be aware of the symptoms: fever, intense muscle pain, and difficulty breathing. If someone experiences these symptoms and has been in rural or semi-rural areas where the long-tailed pygmy rice rat may have been present, they should immediately go to a health center and inform the medical staff so that a hantavirus diagnosis can be considered promptly,” the official added. Since December 2025, the Pan American Health Organization (PAHO) has maintained an epidemiological alert due to the rise in hantavirus cases throughout the Southern Cone, and that the Ministry of Health had an epidemiological alert in place since November of last year. Chile eliminates leprosy As mentioned above, the Health Alert decree also covers diseases transmitted by the Aedes aegypti, Aedes vexans, and Anopheles pseudopunctipennis mosquitoes, such as dengue and Zika, which, according to the alert, “have a high epidemic potential, which could generate high demand and overload for health facilities.” For these diseases, the alert is in effect from Arica to Los Ríos. The authority stressed that it is essential to prevent mosquitoes from breeding in stagnant water and to monitor any suspected cases of people arriving from abroad infected with any of these diseases, in order to prevent any of these vectors from biting a sick person and starting to spread the disease. In the case of avian influenza, the alert was extended to the entire country, because unlike other years, the disease has been concentrated in wild and farm birds, not in poultry farms, increasing the risk of exposure for people. Outbreak News Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe
What Businesses Are Saying: Steady Overall With Pockets of Stress
Businesses reported durable demand from consumers and are keeping headcounts flat through the end of 2026. Pricing pressures continued, but with some pullback from low- and middle-income customers.
How children talk can indicate risk for future mental health problems
Linguistic models that analyzed the words children used when talking about stressful events were better at predicting future mental health problems than a panel of human experts.
After Hobbes vs Rousseau: Politics must move beyond human nature
Since the great debate between Hobbes and Rousseau, our political theory has been organised around a single question: is human nature essentially good or essentially corrupt? Graham Harman, the philosopher behind object-oriented ontology, argues that this is simply the wrong question to be asking. The real forces governing our collective fate - climate change, artificial intelligence, geography, and pandemics - are non-human; therefore, questions about human nature are not the central ones. Instead, Harman proposes a politics reorganised around our relationship to non-human objects and environments, in which quasi-government institutions incentivise and deter actions with the aim of extending the survival of the human race. “It is easier to imagine the end of the world than the end of capitalism.” This has become one of the most popular phrases among twenty-first-century intellectuals. Often misattributed to Fredric Jameson, it has been warmly embraced by such influential authors as Slavoj Žižek and the tragically departed Mark Fisher, and has fueled the notion that the major problem with the political Left is that it simply needs to become more speculative and creative. Naturally, this is never a bad idea in any human pursuit. But what if the political distinction between Left, Right, and Center itself results from a failure of imagination? SUGGESTED READING Hobbes vs Rousseau: are we inherently evil? By Robin Douglass This particular division has been with us only since the summer of 1789. During the simmering prelude to the French Revolution, it referred originally to the physical position in the National Assembly of radical figures on one side and loyal monarchists on the other. These positions are linked with two entirely different camps of modern political theory. On the Left we find a series of authors ranging from the moderate (Locke) to the supercharged (Rousseau) to the truly radical (Marx), all of them contending that exploitation of the many by the few justifies revolutionary overthrow of the existing order. On the Right they are countered by the likes of Machiavelli, Hobbes, and Schmitt, a group of thinkers convinced that corrupt human nature can be tamed only by force. In the words of the Nazi supporter Schmitt: “One could test all theories of nature and state and political ideas according to their anthropology and classify these as to whether they consciously or unconsciously presuppose [humans] to be by nature evil or by nature good.” This is the division we continue to face today, even in the daily retail politics of Western democracies.___Our species has regularly proven itself capable of both the noblest gestures and the most scathing cruelties, making it hard to define us as essentially either emancipatory or brutal in our aims.___The most refreshing feature of David Graeber and David Wengrow’s 2021 book The Dawn of Everything: A New History of Humanity was their awareness that the forced choice between Rousseau and Hobbes (as they put it) is no longer sufficient. Our species has regularly proven itself capable of both the noblest gestures and the most scathing cruelties, making it hard to define us as essentially either emancipatory or brutal in our aims. Far from being stationed “beyond good and evil,” we seem to be fully entangled with both. We are not naturally good or evil, Graeber and Wengrow contend, but naturally experimental and imaginative. They rest their case on the archaeological record, which seems to bear witness to numerous episodes of seasonally shifting governments and festivals, which vacillate in the same society (even in the same year) between the egalitarian and the dictatorial. Such praise of political experiment makes a good fit with the generally anarchist position defended by these authors. Yet it is also what I find most disappointing in their position. Although they are right that the forced choice between Hobbes and Rousseau falls short of what our new situation requires, the authors simply replace it with praise for the human being as a political tinkerer and performer. In other words, they give us just another theory of human nature, one that would not have been out of place in the sixteenth or seventeenth century. What other options might we have?___The time is ripe for a retheorization of politics on the basis of something other than human nature… We are not just alienated and limited by objects, but also empowered and unleashed by them___One fresh approach would be to treat politics within a broader framework than human nature, given that the polis does not exist in a vacuum filled exclusively with people. When Bruno Latour went to observe the baboons of Kenya with the San Diego anthropologist Shirley Strum, they jointly concluded that these primates were more socially interdependent than our own species. Each baboon is so reliant on the dynamics of the group that they find themselves locked into constant surveillance of their potentially dangerous peers. The group structure turns out to be inherently volatile. Humans, by contrast, are able to stabilize their societies to a large degree through the mediation of inanimate objects. Although one’s position in society may seem to fluctuate over time, considerable stability is produced through such items as apartment keys, wedding rings, and identification cards, all of them serving to secure us a place distinct from that of our fellows. The Italian philosopher Maurizio Ferraris has written at length about the crucial role of documents in establishing social relations, making him a hero among notaries in his country. Proper names and license plates cement our position amidst other humans, as do symbolic achievements such as graduation from a top university or distinguished wartime service with its various medals and ribbons. None of this is found among baboons, despite their closeness to us on the evolutionary tree: after all, we did share a common ancestor just 25 to 30 million years ago. SUGGESTED VIEWING The goodness paradox With Richard Wrangham The time is ripe for a retheorization of politics on the basis of something other than human nature, whether understood in the manner of the Left or of the Right. We are not just alienated and limited by objects, but also empowered and unleashed by them. But initially, it is true, we face non-human things primarily in the form of constraints. It would be difficult, perhaps impossible, to form a human civilization underwater, deep underground, atop Mount Everest, or in outer space. Human dependence on the non-social background takes on subtler form in discussions of political geography, especially unloved on the more idealistic Left. Consider the luckless position of Poland during World War II, sandwiched between Hitler on one side and Stalin on the other. By contrast, note the good fortune of the United States in not having a military peer positioned on any land border. Anglo-American geopolitics, since the writings of the American naval commander Alfred Thayer Mahan and the British geographer Sir Halford Mackinder, has been wedded to the notion that one or more liberal offshore naval powers should prevent any authoritarian “heartland” regime from gaining effective control of Eurasia. That remains the case whether the opponent is the impatient Napoleon, the swashbuckling German Kaiser, the villainous Hitler, the murderous Stalin, or the industrial juggernaut Chinese. In their current Foreign Affairs article “Heartland vs. Rimland,” Michael Beckley and Hal Brands analyze the current and coming state of the world on the basis of these same rather durable principles. In recent years a similar outlook has been embraced, in inverted form, by the Putin-loving Russian philosopher Aleksandr Dugin, an icon of the Rightist intellectual underworld. For Dugin, the Anglo-Saxons are an evil force bent on destroying the spiritually superior people of the land: much like Athens in its failed war with Sparta, or Carthage in its eventual collapse against Rome. But the shared notion on both sides is that any strategy that fails to take geography into account is likely to end up as a defeated form of excessive optimism.___When dealing with environmental degradation, then, we are doing business with forces that promise dire effects on our species as a whole.___More striking for us today than geography is the non-human object called climate, which threatens rimland and heartland equally. Even if we contend that humans are one hundred percent responsible for triggering the climate crisis, it remains non-human in the sense of being an independent force beyond our effective control. In a major work published just before his death in 2002, The Structure of Evolutionary Theory, the American paleontologist Stephen Jay Gould noted the tendency of evolutionary theorists to focus too closely on the fate of individuals in view of their successful or failed adaptation to circumstances. With climate change, however, we confront a force that goes well beyond the scope of any individual life. Whereas Richard Dawkins extended evolutionary questions downward from individuals to the sub-individual gene, Gould pushed it upward, speaking of entire species or clades as impacted by environmental change. The asteroid that struck the Yucatán 66 million years ago is only the most famous example of this sort. In the wake of that catastrophe, large animals needing abundant supplies of food were at a fatal disadvantage by contrast with the smaller birds and mammals of the planet. When dealing with environmental degradation, then, we are doing business with forces that promise dire effects on our species as a whole. The effect is to shift our attention away from individual beings towards the survival of the group.In the United States in particular, the COVID-19 pandemic sparked considerable backlash among those who asserted a nearly absolute degree of individual freedom. In California I encountered those who demanded that their businesses be allowed to reopen, that it was enough to cover their mouths but not their noses, or that they should have the right to enter any public area despite refusing vaccination. Yet public health is probably the clearest argument against libertarianism, which often merely asserts the autonomy of individuals against any claims of the commons. In normal times the individual is worth defending; under conditions that threaten the survival of part or all of our species, compulsion may be our only resort, as with perfectly reasonable blackouts and rations in wartime. To rebuild human society under the constraints of climate change will be one of the great challenges of the century to come, as will our improvised grappling with artificial intelligence. Such phenomena pose existential risks for humanity, and leave far less room for tolerance of individual brattiness. Cases are mounting of devastating wildfires caused by arson. Recently it was reported that there is even a website where one can bet on the location of coming wildfires, raising the specter of deliberate blazes set to collect on wagers. The death penalty has steadily lost support in a world where many stress the infinite value of human life. But if we focus instead on entire ecosystems, those who purposely burn the forests may begin to look worse than serial murderers.___The politics of the future may be splintered by disagreement over such topics as how to manage our environing background and how to permit or restrict the entry of new objects into the political sphere.___So far I have spoken of force, authority, and punishment: measures sure to have greater appeal to those who identify with what we know as the Right. But other implications of the post-anthropocentric world are likely to have different backers. If non-human objects are seen as structuring political space, it stands to reason that they can no longer be introduced solely by the pace of technical breakthrough. Fields ranging from cybernetics to energy will demand increased politicization once they are reconceived not just as products of individual human investment, but as renovations of collective political geography. This need not involve world government, with its inherent risk of tyranny, but may involve quasi-governmental enforcers of prestige along the lines of a less corrupt FIFA or International Olympic Committee, punishing deviant states not with violence but with less tangible incentives.Politics will never lose its historic links with conflict and faction. But rather than factions aligned by differing theories of human nature, the politics of the future may be splintered by disagreement over such topics as how to manage our environing background and how to permit or restrict the entry of new objects into the political sphere. This will prove just as incommensurable with the modern Left/Right spectrum as a globe is with a two-dimensional map.
Health experts give warning about popular fidget toy ‘Needoh’
A popular fidget toy is keeping little hands busy, but there are a few things to be mindful of to make sure the kid-friendly toy remains a stress reliever.
Doctor Reveals No. 1 Sign Your Stress Is Becoming a Chronic Condition
In TODAY.com’s Expert Tip of the Day, NBC News medical journalist Dr. Akshay Syal explains the main trait he looks for when diagnosing chronic stress in patients.
AI's latest casualty? The health of the people building it.
Lilian Weng of Thinking Machines Lab is the only the latest tech executive to resign due to stress and illness.
The Hidden Cost of Stress at Work
Policymakers, employers, and professional organizations have opportunities to design work environments that make us healthier, write Lilly Springer, David Slusky, and Anupam B. Jena.
How drought shaped the Bronze Age world that inspired The Odyssey
A new climate study suggests centuries of drought added pressure to the Bronze Age societies that inspired Homer's The Odyssey, revealing how environmental stress, food insecurity and failing trade networks may have shaped a world of collapse and survival.
Exec burnout and overwork: How 10 business leaders stave off burnout
"I ultimately have to admit that the amount of consistent stress and workload have pushed me beyond what my health can sustain physically," Lilian Weng wrote.
Thinking Machines Lab cofounder steps down, citing stress and illness
Lilian Weng said repeated illness and the pressure of building an AI startup had become physically unsustainable.
Many young adults are failing to launch into healthcare literacy
A poll of parents shows a distressingly large portion of this demographic is at a loss when it comes to scheduling appointments, figuring out whether or not they need medical care or navigating the healthcare system.
Heat stress is rising globally, raising health concerns for billions: Study
Climate change is causing frequent, well-studied, extreme heat events. Less well understood is the additional heat stress experienced by billions of people as a result of those extreme heat events. However, a new study published in Nature Climate Change aims to change that. The study analyzed more than 70 years of climate data stored in […]
Understanding mental health and what drives behavior
Mental health conditions are more common than many people realize, yet they’re often misunderstood, overlooked or difficult to talk about. How to tell stress from something more, and what getting help actually looks like.
Why A Career Change May Benefit Your Health And Well-Being
A career change can do more than improve your professional life. Learn how it can also reduce stress, support your health, and enhance your overall well-being.
Healthcare costs have more than doubled for many farmers this year, on top of soaring expenses
When Congress allowed Affordable Care Act tax credits to lapse, healthcare premiums spiked for millions of Americans — especially self-employed farmers and ranchers. That added cost is multiplying the stress on their already stretched balance sheets.
How financial stress can affect the brain over the long term
People who experienced persistent financial struggles were slower to process information and showed memory recall decline by middle age.
Dear Abby: Jeanne Phillips bids adieu as 'Dear Abby' endures
DEAR READERS: As anyone who reads “Dear Abby” knows, I have always stressed the importance of writing thank-you notes. It is now time for me to put pen to paper.
AI mental health chatbots feel empathetic, but safety evidence still lags
Immune dysregulation may contribute to depression, schizophrenia, bipolar disorder, and anxiety through chronic inflammation, altered neuroimmune signaling, genetic susceptibility, and stress-related epigenetic changes. Evidence also suggests that biologically defined patient subgroups may benefit from more precise, immune-informed approaches to diagnosis and treatment.
A day in the life of a Nasa behavioral health scientist
Dr Suzanne Bell helps astronauts perform in a high-stress environment. To do that, she wakes up at 5am – without an alarm
A day in the life of a Nasa behavioral health scientist
Dr Suzanne Bell helps astronauts perform in a high-stress environment. To do that, she wakes up at 5am – without an alarm
California health officials stress vaccinations as school year approaches
As the school year approaches, California health officials are urging parents to update their children's routine vaccinations to comply with state requirements and prevent disease outbreaks.
Statewide: Farmers and mental health
Financial stress and a lack of mental health resources in rural areas contribute to the problem.
Ranked: US cities where people are the most stressed
Some cities in America are more stressed out than others, an analysis by WalletHub shows.
Parents Benefit from NICU Mental Health Support
A Cincinnati Children’s-led study finds that NICU-based mental health support can reduce anxiety, stress and depression among parents, suggesting these services should become part of standard neonatal care.
Health: Searching For The Source Of Cyclospora
You may have heard of a parasite that’s causing some gastrointestinal distress.Cyclospora has sickened thousands of people across 34 states this summer – more than six times the number reported at this point last year. The CDC has linked a major cluster to shredded iceberg lettuce at Taco Bell in some states. And Taylor Farms de Mexico has now pulled all of its iceberg lettuce from the U.S. market despite an FDA finding that reports that its product contained the parasite were a false positive.We answer your questions about what cyclosporiasis is, how you get it, and why investigators have had such a hard time finding the source.Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Family stresses need for mental health resources after man's accused of killing his aunt
Columbus family members said they're morning two people - a woman who died and the man accused of killing her."It's just tragedy across the board, you know?,"
Gardening is linked to a longer life. Here’s how it helps your body.
Even a few sessions a week can provide moderate exercise, sensory stimulation, stress relief, and a stronger sense of purpose.
Emergency nurses know what it’s like to suffer pangs of moral distress
Like the emergency physicians they work alongside, ER nurses experience moral distress in substantial numbers and multifaceted ways, according to a new study published in the Journal of Clinical Nursing.
'Saved the day for us': Local business steps up to help Big Brothers Big Sisters after S2 eviction
What was supposed to be a time of celebration and fundraising for an Idaho non-profit quickly turned stressful after their event location closed with just days’ notice. Thanks to another local business that stepped in at the last minute, they were able to pull off their most successful fundraising event ever. Big Little Dill Big […]
The rave secret: why middle-aged women are larging it – and seeing big health benefits
For those who are burned out, perimenopausal, or both, dancing all night can be a panacea. It’s great exercise, lowers stress, boosts energy and provides connection. No wonder so many are doing it
Major water company in distress as pool business collapses
Pentair (PNR) was one of the pandemic's quiet winners, riding America's backyard pool boom. However, that run ended this week. The company pre-announced weak second-quarter results on July 14, cut its full-year outlook, and revealed its CFO had left four days earlier. Shares dropped about 15% the ...
At a Florida fundraiser, Pete Buttigieg stresses the need to ‘restore democracy’
Buttigieg’s message ahead of a potential presidential run has focused on how the nation’s most important institutions need a major course correction to survive.
New York Yankees’ Aaron Boone Provides New Aaron Judge Update
The New York Yankees have been navigating their schedule without the help of slugger Aaron Judge.As recently announced, Judge has been transferred to the 60-day IL as of July 18 due to a stress fracture of the first rib on his right side.Manager Aaron Boone has now provided an additional statement on Judge’s status.Yankees’ Aaron […] The post New York Yankees’ Aaron Boone Provides New Aaron Judge Update appeared first on HEAVY.
Coffee may help the body fight stress and aging through a hidden cellular switch
Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.
Coffee may help the body fight stress and aging through a hidden cellular switch
Scientists may have uncovered one reason coffee is repeatedly associated with healthier aging and lower disease risk. Compounds in coffee appear to activate NR4A1, a receptor that helps protect cells from stress, inflammation, and damage. These protective effects disappeared when the receptor was removed, strengthening the connection. Surprisingly, plant-based compounds such as caffeic acid seemed far more active than caffeine itself.
Jim Parsons says he wouldn’t star on ‘The Big Bang Theory’ again ‘for any amount of money’
Despite the fame and accolades, ‘The Big Bang Theory’ star Jim Parsons says that the show’s cultural peak was ‘stressful’ and ‘miserable,’ admitting that he wouldn’t do it again ‘for any amount of money.’
'Just stop burning fossil fuels.' Scientists stress that our smoky skies only have one true fix
Smoky skies in Toronto have led to new scrutiny of government efforts to fight fires and manage forests. But scientists say the realistic way to tackle the smoke is fighting climate change itself.
Hochul drums up support for data center moratorium
The roundtable included perspective local government leaders, those in the agricultural industry, and utility advocates who stressed the need to plan ahead
Yankees Insider Reveals Stressful MLB Trade Deadline Update
New York Yankees fans will be stressed over this MLB trade deadline news.
Police: speculation during Widdecombe murder investigation is ‘unhelpful and distressing’
Politicians should not comment before facts are established, says former chief constable, after Farage describes killing as ‘premeditated murder’
Why the Real Bottleneck in Your Business Is Biological
Great leadership comes from managing stress and decision-making by protecting and optimizing the brain’s ability to think under pressure.
Miniatures make a comeback as young people seek to relieve stress
Life is uncertain. But there is one place where all is serene and predictable - the world of miniatures. “Unlike in real life, things are perfect in the miniature world,” says Lee Thomas Seawell, 66, ...
Dr Oz shares free health changes Americans can make now to live longer, happier lives
Dr. Mehmet Oz discusses how meaningful relationships, restorative routines and screen-free evenings can help reduce stress and support more restful nights.
How climate change harms human health — and what can be done
From air pollution to wildfires, from heat waves to vector-borne diseases, climate change harms our health and causes significant stress to the healthcare system. Horizons moderator William Brangham explores what can be done to protect people from a warming world with Victor Tsao of the U.S. National Academy of Medicine and Lisa Patel of the Medical Society Consortium on Climate and Health.
What Watching a Soccer Final Does to Your Body, According to Science
A recent study tracked hundreds of soccer fans until their favorite team reached the final of a tournament. Their stress levels skyrocketed, and their heart rates jumped too.
MORNING BUSINESS REPORT: Grocery prices stress, Costco app
Families say grocery prices cause them the most financial stress and Costco allows customers to pay through its app. Here's the Morning Business Report for July 10.
1 in 5 teens are using AI for mental health -- Here’s what parents need to know
A new study finds 1 in 5 teens and young adults are turning to AI when they are feeling sad, stressed or scared.
Graham Platner says he'll withdraw from Senate race in Maine
Platner stressed that his decision was not an admission of guilt.
Dr Oz links obesity to chronic disease surge, says GLP-1s can 'jumpstart' better health
Dr. Mehmet Oz backs GLP-1 weight loss medication, but stresses that diet and exercise remain essential, calling obesity the top driver of healthcare costs.
A Dog Named Dug: The Science Behind Therapy Animals
Through the Cornell Companions program, volunteer therapy animals on campus bring emotional and neurochemical benefits to students during stressful times.
Balancing mental health with sound
How do we take care of ourselves when we are so busy working and taking o stress and exhaustion because we are taking care of everything and everyone else?
A spirit of resilience helps Venezuelans face healthcare challenges after the quakes
The economic collapse of Venezuela has pushed its healthcare system to the brink. The disaster is now adding to the stress.
The 8 healthy habits doctors wish more people would bring back
Rates of chronic disease, obesity and stress continue to rise across America. Experts warn that some of the healthiest habits from the nation's earlier centuries may have fallen by the wayside.
Doctors say 8 forgotten habits could help fight stress, obesity and chronic disease
From walking everywhere to eating seasonal foods and sharing community meals, experts say these forgotten American health habits are worth reviving.
On the California Coast, a Picture-Perfect City Falls on Hard Times
Santa Monica is starting to bounce back from a state of “fiscal distress” including financial woes, declining international tourism and fading retail.
Many Celebrities Apparently Got The Same Warning Before Going On David Letterman
This would be so stressful.
'Tanmaxxing' trend could come at a dangerous cost, skin cancer experts warn
A dermatologist warns that "tanmaxxing" is causing DNA damage, calling the Gen Z tanning trend a "visible distress signal" rather than a wellness upgrade.
Old muscle stem cells can act young again but there’s a catch
Scientists at UCLA discovered a surprising reason aging muscles heal more slowly. In older muscle stem cells, a protein called NDRG1 builds up and acts like a brake, slowing the cells’ ability to jump into repair mode after injury. But there’s a twist: that same protein helps the cells survive the stresses of aging, allowing them to stick around longer.
Kitchen workshops stress dairy’s role in health
Learn more about Kitchen workshops stress dairy’s role in health, News and College of Health Sciences. Texas Woman's University (TWU) is the nation's largest un
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
Politics: High Cost Of Healthcare And The Political Fallout
Americans are grappling with a rising cost in healthcare. For the first time in five years, fewer than half of Americans can consistently afford healthcare. That’s according to the latest data from Gallup. The cost of healthcare in the US remains higher than any other large, wealthy country. According to a report from the Department of Health and Human Services, five million fewer people are enrolled in marketplace plans for 2026, compared to last year. That’s as average premium costs rose about 58%.With health care costs increasingly becoming a stress for Americans, voters are now making the issue a top priority at the ballot box. And it’s an issue that crosses party and geographic lines. According to new polling from The Century Foundation, 71% of Democrats, 66% of Republicans and 75% of rural voters agree that reigning in hospital costs should be a top priority for lawmakers. While new polling from Ipsos and Axios suggests that a majority of Americans say they’re more likely to vote for candidates in November who will lower their health costs.How will the issue of healthcare shape the midterms? And how are Americans grappling with the cost of their health?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.
America's national parks could add years to your life — here's how they boost health
National parks offer more than scenic views. Research shows trails and greenways boost physical activity, reduce stress and improve mental health.
Recent Research on How Experiencing Racial Discrimination Impacts Health
This brief provides an overview of the relationship between racial discrimination and health and highlights research examining mechanisms underlying health outcomes linked to experiences of racial discrimination, including biological changes, chronic stress, mental health, substance use, pregnancy-related outcomes, and sleep.
ARDS patients improve with experimental treatment
JUPITER, Fla. — Doctors have few options for patients who develop a life-threatening lung condition called acute respiratory distress syndrome, or ARDS. A…
Want to Feel Less Stressed or Anxious? Science Says Just Fake a Smile
Research shows a 20-second fake smile 'improves physiology during acute stress, improves stress recover, and reduces illness over time.' Can't beat that.
Leading Colorado toward modern mental health solutions
By Sean Camacho America is facing a silent crisis. Millions of Americans are living with invisible illnesses like generalized anxiety disorder (GAD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD), which decrease quality of life and, amid limited treatment options, create a vicious cycle of endless medications and, for many people, hopeless therapies. This […]
Mpls council member cites 'mass shootings, federal occupation' for mental health leave
Minneapolis City Council member Aisha Chughtai said on Monday that she plans to take a month-long break from city activities to seek care for her mental health, citing stressors such as an election, mass shootings and a federal occupation as stressors for her condition.
Addison Barger Will Be Out Longer
The start of another series, and all I’m thinking is ‘don’t be swept’. That stuff about Addison Barger being back soon? Not so much. He has a ‘stress reaction in his back’. I guess that means stress fracture, but he’ll be shut down for two more weeks. So let’s hope that he might be back […]
Students in Distress Turning to AI for Mental Health Support, Study Shows
Nearly one in five college students is turning to AI for mental health reasons, and those with severe symptoms are roughly twice as likely to do so.
The World Cup is a stress test for our public health system. We failed it even before kickoff.
Soccer matches across North America are attracting people from around the world who are crowding stadiums and public transit, places where infectious diseases can be easily and widely spread.
Couple retired to Costa Rica with 2 sons; bought a $1.6 million house
"We fill every day. There's really not a lot of downtime, yet we never feel rushed or pushed or stressed," Andrew Rappaport told BI about life in Costa Rica.
Being broke costs you 13 IQ points, according to science. Here's the number that changes everything.
CreditNinja reports that saving your first $10,000 unlocks financial stability, improving decision-making and reducing stress, ultimately boosting cognitive function.
Science Debunks a Common Belief About Pets and Stress
Scientists found that spending time with cats and dogs can improve owners’ mood, but not through the stress-relieving mechanism they anticipated.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Around the MHS
This edition of news from around the Military Health System for the week of June 22-26, 2026, includes a vital partnership between Offutt Air Force Base and the American Red Cross, new Uniformed Services University research on stress fractures, and Naval Medical Research Unit EURAFCENT participates in a multinational readiness exercise.
Aon Center owner seeks another loan extension as tower’s value plummets
The debt trouble at Chicago’s second-tallest office tower is one of the largest cases of imminent distress downtown amid weakened demand for workspace.
Ravens rookie Ja’Kobi Lane details emotional draft-day moment
Ja’Kobi Lane recalls the intense stress and emotional relief of the moment he finally received his NFL draft call.
Mental health partnership aims to give young doctors in training the self-care skills to cope with stress of the job
Becoming a doctor requires long hours, over many years, often with a lot of stress. A mental health program at CU Anschutz aims to give young doctors the
One common fat may fuel type 2 diabetes while another helps fight it
Not all fats affect your body the same way. Researchers found that palmitic acid, a saturated fat common in many foods, may contribute to insulin resistance and type 2 diabetes by triggering inflammation, toxic fat buildup, and cellular stress. In contrast, oleic acid—the heart-healthy fat abundant in olive oil—appears to help protect insulin function and may even counter some of the harmful effects of palmitic acid.
Dad jokes may be good for your brain in one surprising way, experts say
Dad jokes can lower cortisol by over 36% and boost dopamine, serotonin, and endorphins, offering real stress relief through simple puns and wordplay.
Earth’s early life was terrible at sex, say scientists
Sexual reproduction only began to improve when early animals began facing more stress and competition, a study suggests.
Catholic mental health leader calls for greater support for clergy and religious
We need “to make sure that we are always aware of the stressors that come up in their lives. While they’re called to ministry, they are human first,” he said.
Dangerous Fault Lines in California at Highest Pressure in 1,000 Years, Scientists Warn
"The system is in a critically loaded state."
Austin Transit Partnership reviews light rail design as business stresses about relocation
Austin’s long-debated light rail project moved into another phase as the Austin Transit Partnership met to discuss design and preconstruction work, while some b
Ozempic and Wegovy linked to surprising drop in violent behavior
A Rutgers study suggests GLP-1 drugs such as Ozempic and Wegovy may weaken the link between impulsive tendencies and violent behavior. The surprising finding hints that these medications could affect how people act on impulses, though researchers stress that cause and effect have not been proven.
I tried this stress-reducing device. Did it calm me down?
We all know what stress feels like. But what if you could find out exactly just how stressed you were at any given moment?
WHO Step-by-Step programme recognized as a promising innovation for mental health in humanitarian settings
WHO, in collaboration with the Pan American Health Organization (PAHO) and Lebanon’s National Mental Health Programme, showcased Step-by-Step at the World Bank Group’s biennial Fragility Forum in Washington, DC. The forum convened more than 1500 representatives from governments, international organizations and civil society to advance the development agenda in the world’s most fragile and crisis-affected communities. WHO was invited to demonstrate Step-by-Step – a digital self-help intervention for depression, alongside innovations presented by Stanford University and Google. The World Bank Group selected Step-by-Step from among more than 50 innovations that they reviewed in the lead up to the Forum.About Step-by-StepStep-by-Step is a free digital tool developed by WHO in collaboration with Lebanon’s National Mental Health Programme and other partners, that helps people manage depression and anxiety on their own, with light guidance from a trained supporter. It uses a picture-based story to walk users through evidence-based techniques for managing common mental health conditions. Users complete five modules, with weekly contacts – of around 15 minutes each – from a trained non-specialist helper, such as a community health worker.Evidence-basedClinical trials in Lebanon involving nearly 1250 participants – including 680 Lebanese participants and 569 Syrian participants – showed that Step-by-Step significantly reduced depression, anxiety and stress, and improved daily functioning. By the end of the programme, a reduction in depressive symptoms of more than 50% was reported by almost half (46%) of Lebanese participants and more than one third (37%) of Syrian participants compared to approximately 14% of those who did not use the programme. Cost-effectiveness analyses further suggest that Step-by-Step may offer a cost-saving response to depression in humanitarian emergencies in low- and middle-income countries.Used globallyStep-by-Step is already in use nationwide in Lebanon and Thailand, as part of each country’s mental health system. In India, the NGO – Kaya Guides – has adapted Step-by-Step for delivery through a widely used messaging app. Together, these programmes have provided thousands of people with evidence-based support for depression. The content is freely available from the WHO website for any organization or country to adapt for their own context.A new implementation guideThe Fragility Forum coincided with the recent launch of WHO’s new practical guide: Psychological self-help interventions: delivering self-help for individuals, featuring Step-by-Step and Doing What Matters in Times of Stress (WHO, 2026). The guide is designed to help governments, health workers, organizations and planners bring evidence-based mental health support to more people, particularly in low-resource and crisis-affected settings.
Got World Cup Fever? Send scientists your smartwatch data.
For fans, stress levels can skyrocket even 14 hours before kickoff.
'The system is critically stressed': San Andreas and San Jacinto faults scarily close to major earthquake, study finds
The San Andreas fault and a neighboring fault in Southern California have reached their highest levels of tectonic stress in 1,000 years, and a rupture at one fault could propagate to the other, researchers found.