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The new "science golden age" looks suspiciously like a grift

This edition of PN is made possible by paid subscribers. Become one ⬇️ 🚀 Subscribe to PN 🚀 The Trump regime is trying to usher in a “Golden Age in Science” where scientific research is run like a Trump family business, artificial intelligence is all that matters, profit is everything, and expertise is for chumps. Or at least that’s the vision emerging from a new 123-page “Report to the President” from Michael Kratsios, the Director of the White House Office of Science and Technology Policy. In a normal administration, you could probably skip over learning about a science policy document — but this is no normal administration, and this is no normal science policy document. Instead, it’s Trump’s attempt to end the actual golden age of science that was kicked off in 1945 with the publication of '“The Endless Frontier” by Vannevar Bush. [ ](https://www.publicnotice.co/p/harmeet-dhillon-portland) [ Harmeet Dhillon demonstrates danger of posting through it ](https://www.publicnotice.co/p/harmeet-dhillon-portland) Liz Dye · Jul 29 [ Read full story ](https://www.publicnotice.co/p/harmeet-dhillon-portland) Bush, at President Franklin Delano Roosevelt’s request, laid out a vision of federal support for science that centered on funding universities to do basic research, saying that as long as those institutions were “vigorous and healthy and their scientists are free to pursue the truth wherever it may lead, there will be a flow of new scientific knowledge to those who can apply it to practical problems in Government, in industry, or elsewhere.” Kratsios’s report is supposed to be the successor to Bush’s, and even apes the format, but this isn’t really a document about science policy. It’s one about ending science research as we know it in favor of shoveling cash at big tech companies. While it might be temping to wave this away as an aspirational policy document, Trump has already begun to shift billions in research funds to AI projects and has taken a hatchet to science funding across the board. He’s teed up the shift Kratsios proposes here, and since neither Congress nor the Supreme Court seem inclined to stop him from doing whatever he wants with taxpayer money, it isn’t doomering or hyperbole to say we are staring down the barrel of a world where the only “science” the government intends to support is for-profit tech and defense advancements. Science for dummies Part of how you can tell this isn’t a document about science is that you are immediately faced with an absolute wall of business-speak of the worst sort. Did you know we must “tightly couple our science and technology enterprises to ensure that groundbreaking ideas invented in the United States are rapidly prototyped, tested, manufactured, and scaled domestically”? You do now! That tone isn’t surprising, because Kratsios has no background in science or research. He has a bachelor’s in political science and spent most of his career working for Peter Thiel at Thiel Capital. After a stint in the first Trump administration as Chief Technology Officer, where he also did not do any science, Kratsios was tasked in 2020 with overseeing the Pentagon’s research budget for a brief time, a position that, as the Wall Street Journal put it, “carries a great deal of power in terms of dictating investment allocations.” He spent the Biden years at Scale AI as “head of strategy,” which you will also note is neither a science nor a research job. But Scale AI has contracts with the Department of Defense and, as the Washington Post wrote in 2023, “has been aggressively pitching itself as the company that will help the US military in its existential battle with China.” And now you have the necessary background for our new golden age, which is going to be a golden age of taking money away from scientists and universities and giving it to companies like Scale AI. A note from Aaron: Working with brilliant contributors like Lisa takes resources. If you aren’t already a paid subscriber, please become one to support our work. 👇 Subscribe In a genuinely galling move, Katsios spends a lot of time slamming universities because of “administrative burdens on researchers” and the “well-documented inefficiencies” in academia, the message being that those damn universities waste the time of amazing researchers with paperwork. Except it’s the administration that is attempting to impose inefficient, unnecessary burdens on those researchers with a proposed Office of Management and Budget rule that would require senior political appointees to approve every science grant and ensure it aligns with Trump’s personal priorities. Researchers would also have to seek prior government approval to attend conferences or publicize their research. And political appointees could terminate any grant at any time if they feel like it. [ ](https://www.publicnotice.co/p/omb-rule-science-funding) [ The murder of expertise ](https://www.publicnotice.co/p/omb-rule-science-funding) Lisa Needham · Jun 11 [ Read full story ](https://www.publicnotice.co/p/omb-rule-science-funding) But when it comes to AI, we’re going to “restore permissionless innovation.” The report proposes to give lucky ducky innovators a pile of cash up front for grants lasting five years or longer, saying “awards should be fully-funded in year one, with all resources earmarked upfront, to minimize administrative burdens and reduce pressure for researchers to generate intermediate results to secure continued funding.” Yeah, wouldn’t want to have to make the Very Special Tech Bros show results or get money parceled out year by year like the plebes at universities. The report also proposes that we should have “fast grants” with “simplified applications requiring just a few pages of writing” because that is definitely how science works, just writing a bit off the dome and getting some cash. [ ](https://www.publicnotice.co/p/trump-ai-action-plan-altman-llms) [ Tech elites are turning AI into ChatGPTrump ](https://www.publicnotice.co/p/trump-ai-action-plan-altman-llms) Paul Waldman · July 29, 2025 [ Read full story ](https://www.publicnotice.co/p/trump-ai-action-plan-altman-llms) Oh, and we should have prizes and challenges, where multiple teams compete. The proposed prizes include incentives like “advance procurement commitments,” which means the federal government agrees to buy whatever is being developed. There’s also “regulatory fast-tracking,” making sure all those great AI thingies don’t have to wait too long to be unleashed on a market. These aren’t incentives to do science. These are incentives to develop things with tax dollars that you can then sell to the government for more tax dollars. In the suggestion that might be the most unhinged, the most very opposite of how both government and research work, our new age will include “golden tickets.” That’s where an individual reviewer in an agency — yes, just one person — can “recommend unconventional proposals that may not pass consensus-driven review panels” because somehow this will “surface valuable ideas too divisive for committees and attract higher quality reviewers by empowering them to exercise independent scientific judgment.” Yes, that’s saying that a random person in an agency should be able to shovel money at some idea even if it can’t pass a review panel, and that the opportunity to do so will attract better employees because apparently all the best minds in science are chomping at the bit to be allowed to unilaterally fund AI research based on their personal vibes. But that isn’t at all how actual science works, and actual scientists aren’t unhappy about review panels. They work collaboratively, not siloed in some secret race to create the next AI chatbot. A 2020 study by the National Bureau of Economic Research examined whether peer review panels succeed in helping agencies predict which research ideas will best advance science. Peer review was better at finding “diamond in the rough” applicants than a single government program official. How about that. Trump always wants a taste It’s painfully clear that what Katsios is trying to do here is turn the whole of government science research and funding into the sort of “move fast and break things” paradigm that is the hallmark of big tech. That method works to line the pockets of tech executives, but it isn’t science. There’s a reason the government funds different kinds of research than private tech companies do. What Katsios either fails to understand or deliberately ignores is that the federal government is the main funder of basic research precisely because it can take a long time for it to bear fruit and is not intended to be profitable as such. “Basic” here does not mean rudimentary or simple, but rather research that is designed to advance scientific knowledge instead of achieving a specific outcome or product. Big tech companies don’t widely fund that sort of research, because it doesn’t make them money. Industry dollars account for only about 20 percent of basic research funding, while the government contributes around 60 percent. Big tech companies and startups do, however, rely on and benefit from that basic research. A 2019 study found that 35 percent of all patents obtained by venture-backed startups from 1976 to 2016 cited federally supported research. Basic research funded by the NIH contributed to every single drug the FDA approved from 2010 to 2016. [ ](https://www.publicnotice.co/p/trump-saudi-nuclear-deal) [ The Saudi nuclear farce and governance by whim and meme ](https://www.publicnotice.co/p/trump-saudi-nuclear-deal) Noah Berlatsky · Jul 27 [ Read full story ](https://www.publicnotice.co/p/trump-saudi-nuclear-deal) Unlike inventing the next ChatGPT, actual science is slow and iterative. Government funding of research that, on its face, would not appear to lead to any big new invention is actually what underpins those big new inventions. If the government hadn’t funded research into desert lizard venom, we wouldn’t know about semaglutide, and we wouldn’t have Ozempic. If research scientists hadn’t studied how bees optimize nectar foraging within a colony, we wouldn’t have the algorithm that assigns internet traffic across computer servers. The report assiduously ignores that a symbiotic, profitable relationship between the federal government, universities, and private companies already exists. Each federal research dollar generates about $1.50 to $3.00 in long-term economic benefits. The $36 billion the government awarded in NIH research funding in fiscal year 2025 generated $94 billion in new economic activity. Trump’s proposed new golden age is intended to strip those billions from universities, resulting in the dismantling of departments and the shuttering of labs. But Katsios has a plan for that: Universities should just become trade schools to churn out no-show STEM degrees! “Require universities and community colleges to embed practical technical training and externships into STEM curricula. Let hands-on experience and industry credentials count toward degrees.” It’s quite the feat to, on the one hand, strip schools of funding for scientific research while simultaneously demanding to control what is taught and, oh, also, colleges need to give degrees to employees at big tech companies just for being employees at big tech companies. The new golden age would also exacerbate the brain drain Trump’s policies have already caused. Nature found that in the first quarter of 2025, US scientists submitted 32 percent more job applications abroad than in 2024. A March 2025 poll by Nature of roughly 1,600 scientists found that over 1,200 said they were considering leaving the country. Europe is investing $565 million to make it a “magnet for researchers” and provide funding for scientists who relocate. The new golden age is also about embedding Trump’s xenophobia into the fabric of American science. The report complains of an “over-reliance on foreign students” that “creates a security challenge our institutions are ill-equipped to address” and that a “reliance on foreign talent sidelines American students.” This is, to put it mildly, nonsense. International students pay far higher tuition and often receive no financial aid. Their tuition dollars are what make it possible for American students to get financial aid. In the 2023-2024 school year alone, international students contributed $43.8 billion to the US economy and supported over 378,000 jobs. Those 1.1 million international students accounted for only six percent of the total number of students in higher education that year, but were such an economic engine that for every three international students, one job was created or supported. It’s impossible not to wonder whether part of Trump’s loathing for universities and their leading role in scientific research is that there is no way for him to corrupt the process and make money off it in the same way he can by giving millions and billions to Silicon Valley types who, in turn, give him millions in cash. There’s no way for his children to invest in universities that the government then gives no-bid contracts to, fattening the family’s bottom line, which is pretty much the Trump sons’ current venture capital practice. Trump and Katsios’s view of science is narrow, cramped, and wrong. We’re not in a crisis, we’re not a failed state. We’ve been a science superpower for decades, and the only thing that threatens that is Donald Trump. Tech bros are already living high off the hog in this administration. They don’t need any more of our tax dollars. Hopefully this new golden age never comes to pass. Thanks for reading Public Notice. This post is public so feel free to share it. Share We’ll be back with more tomorrow. If you appreciate today’s PN, please do your part to keep us free by signing up for a paid subscription. 🚀 Subscribe to PN 🚀 Thanks for reading, and for your support.

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Jul 30 • 8:12 AM EDT • Science • publicnotice.co
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Zombie sea cucumbers and the future of tissue engineering | Investors Lab

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Science can serve dark as well as light

I’m not sure how many of you are watching “Star City,” Apple TV’s spin-off of its “For All Mankind” program (2019-present), but it’s one of the better sci-fi series I’ve seen in a while, with an impressively dark political message. (Some light spoilers below.) For the uninitiated, “For All Mankind” presented a slightly tweaked history of the U.S. space program in which it was the USSR that landed on the Moon first in 1969, and shortly thereafter put a woman cosmonaut on the lunar surface. This sparks an ongoing space race that, in the original series, yields a lot of benefits for humanity. President Nixon’s insistence on a female astronaut corps to compete with the Soviets boosts the feminist movement of the 1970s and the ERA passes. New fuels generated for the space program create clean and cheap energy around Earth. There are also some darker changes — the USSR is thriving well into the 2000s, there are terrorist counter-technology movements around the globe, laborers on Mars work in nightmarish conditions and organize strikes and riots, etc. the @smotus report is a reader-supported publication. To support this work, please become a paid subscriber. Subscribe That show offers glimpses into the subtle ways this Earth is different. Teddy Kennedy never went to Chappaquidick because he was racing back to Washington to deal with the space program crisis; he gets elected President in 1972. John Lennon survives his early 1980s shooting but Pope John Paul II does not. The Apple Newton succeeded. Pretty much the whole of season 4 is a setup for an Al Gore joke. Again, mostly, the vision that “For All Mankind” presents is a positive one, with technology advancing many human interests. “Star City” goes in a very different direction. This spin-off show is about the same set of events but from the Soviet perspective. As we meet them, the team of scientists and cosmonauts responsible for the lunar landing are still basking in their hero status, but their program is embedded deep in the Soviet security state of the late 1960s. Everyone’s apartment is bugged. Whole teams of clerical staff spend their days transcribing recordings of people’s lives. People in the program, including respected cosmonauts, are regularly arrested. An incredibly menacing Colonel Lyudmilla Raskova (Anna Maxwell Martin) forces confessions and tortures and kills, expressing little more than annoyance in the process. Meanwhile, the space program’s highly respected Chief Designer (Rhys Ifans) has a vision for the program that he knows the government will not approve. He insists that they need to think past the Moon to focus on colonizing the solar system, starting with Venus. (This is a rough parallel to the Americans’ pivot to Mars in the original show.) He essentially builds a secret space program within the space program, calculating that the government will embrace the mission after it has succeeded. (As an aside, I’m not sure why the Venus obsession, as a successful mission can’t produce the biggest public relations payoff: a cosmonaut standing on the surface holding the Soviet flag. Anyone standing on Venus would be immediately crushed by the 92-bar atmosphere and then cremated in the 900°F temperatures. But in a country with no free press perhaps the visual payoff was less valued.) But the overall vision is that the technological advances have only amplified the most fearsome aspects of the Soviet system. The state is paranoid (but not incorrect) about American spies and does monstrous things to protect its secrets. People are terrified to trust each other. Classic banality-of-evil figures order people to harm those they care about; those people comply rather than get shot. Others are forced into criminal behavior to protect loved ones. We’re reminded all the time these days of what happens when a government despises science. It manifests in the defunding of schools, the elevation of fossil fuels as the rest of the world pivots to solar, outbreaks of measles and diarrhea, etc. But “Star City” offers a vision of a bad government that likes science. It’s not encouraging. It’s not yet clear if there will be a season two of this show. But I strongly recommend season one. It’s both thoughtful and gripping. Share

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Jul 20 • 8:04 AM EDT • Science • smotus.substack.com
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Jul 10 • 8:55 PM EDT • Technology • nintendolife.com
Mississippi mobile sports betting debate resurfaces amid lieutenant governor warning

Mississippi’s debate over mobile sports betting has resurfaced after Lt. Gov. Delbert Hosemann posted a warning on X urging the Senate to reject the measure.

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Jul 9 • 11:36 PM EDT • Sports • wlbt.com
Taylor Frankie Paul reportedly filming again on ‘The Secret Lives of Mormon Wives’

Embattled reality star Taylor Frankie Paul reportedly back in front of the cameras for ‘The Secret Lives of Mormon Wives,’ four months after video surfaced of her throwing a chair at her boyfriend Dakota Mortensen.

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Jul 9 • 11:03 PM EDT • Entertainment • ew.com
Tunable resonant metasurfaces enabled by atomically thin semiconductors

Light: Science & Applications - Voltage-tunable hybrid metasurfaces integrating 2D transition metal dichalcogenides with photonic bound states in the continuum enable dynamic control of...

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Jul 9 • 8:00 PM EDT • Science • nature.com
NASA’s Dragonfly Clears Key Tests as Titan Rotorcraft Takes Shape

NASA’s Dragonfly is starting to look less like a collection of spacecraft parts and more like the rotorcraft that will fly across the surface of Titan,

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Jul 9 • 1:00 PM EDT • Science • science.nasa.gov
Office Politics: Five Things Coworkers Say And What They Mean

Your coworkers are not saying what they mean. These five office politics phrases reveal what is really happening beneath the surface before it costs you your career.

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Jul 9 • 11:57 AM EDT • Politics • forbes.com
Plasma-state metasurfaces for ultra-intensive field manipulation

Light: Science & Applications - Plasma-state metasurfaces for ultra-intensive field manipulation

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Jul 8 • 8:00 PM EDT • Science • nature.com
High-severity guest VM escape is 1 of 2 Linux vulnerabilities to surface this week

Both vulnerabilities allow untrusted users to gain root privileges.

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Jul 8 • 3:01 PM EDT • Technology • arstechnica.com
Weibo leaker says iPhone 18 Pro thickness will be ‘surprising’

Days after materials from Apple supplier Tata surfaced online, prominent Weibo leaker “Fixed Focus Digital” doubled down on his earlier claim that the iPhone 18 Pro will be thicker than the iPhone 17 Pro.

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Jul 7 • 1:42 PM EDT • Technology • 9to5mac.com
Why Democrats need Graham Platner to go away

A lot of people called for Graham Platner to drop out of Maine’s Senate race Monday night, after a rape allegation surfaced against the Democratic nominee. But relatively few of them were Republicans.

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Jul 7 • 11:24 AM EDT • Politics • cnn.com
The sun's atmosphere is way hotter than its surface. Scientists may finally know why

NASA's Parker Solar Probe has found charged grains of dust being carried on magnetic plasma waves in the Sun's outer atmosphere, providing a new clue to the mystery of the Sun's corona is so hot.

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Jul 7 • 6:00 AM EDT • Science • yahoo.com
Top Platner ally turns on him after bombshell rape allegation rocks campaign: 'Red line'

Rep. Ro Khanna withdrew his endorsement and called on Graham Platner to drop out after a sexual assault allegation surfaced against the Maine candidate.

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Jul 6 • 6:35 PM EDT • Politics • foxnews.com
Samsung ‘Galaxy Buds On’ surface with more Galaxy Watch 9, Ultra 2 leaks

Ahead of their launch, expected to be later this month, Samsung has accidentally confirmed its Galaxy Watch 9 and Ultra...

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Jul 6 • 12:55 PM EDT • Technology • 9to5google.com
Changing tides: How gravity warps our oceans - Futura-Sciences

Why gravity makes water uneven Water at any point in the ocean is pulled straight down, perpendicular to what physicists call an equipotential surface. Along this surface, the pull of gravity is identical everywhere. The specific equipotential surface that aligns with global sea level is known as the geoid. On...

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Jul 6 • 8:30 AM EDT • Science • futura-sciences.com
Here's how much the Samsung Galaxy Z Fold8, Z Flip8 foldables will cost in South Korea

The foldables are expected to be announced later this month. Last week, the European pricing for Samsung's upcoming Galaxy Z foldables surfaced online....

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Jul 6 • 8:08 AM EDT • Technology • gsmarena.com
Digital Science brings impact data into AI workflows

AI agents can now surface where research is being discussed, cited in policy, and mentioned beyond academic citations

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Jul 6 • 5:00 AM EDT • Science • researchinformation.info
Scientists have now made the most comprehensive tally yet of deep-sea exploration — 43,681 dive records dating back to 1958 — and found that humans have directly seen less than 0.001% of the deep ocean floor, an area roughly the size of Rhode Island, leaving the vast seafloor across 66% of Earth’s surface essentially unobserved.

Humanity has sent cameras to the Moon, Mars, Venus and the outer planets, but on Earth itself there is still a larger frontier that has barely been looked at directly. A 2025 study in Science Advances has now put a number on that gap: since 1958, researchers have compiled 43,681 records of dives deep enough […]

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Jul 5 • 3:30 AM EDT • Science • spacedaily.com
Steelers install new grass field at Acrisure Stadium after NFLPA survey graded previous surface poorly
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Jul 3 • 5:39 PM EDT • Sports • sports.yahoo.com
Drug-resistant fungus Candida auris still on the rise in the U.S.

Candida auris can “colonize” the skin and spread easily to surfaces.

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Jul 3 • 6:30 AM EDT • Health • nbcnews.com
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Final Fantasy 7 Revelation store page lists multiple DLCs, including story expansion

Last month, we reported that Final Fantasy 7 Revelation, the final chapter of the acclaimed trilogy that is set to launch on Nintendo Switch 2 in 2027, could receive DLC after release. While the game is still a long way off, new evidence has surfaced suggesting that may indeed be the case. According to EpicDB, a third-party tool that tracks...

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Jul 2 • 11:06 AM EDT • Technology • nintendoeverything.com
Global ocean temperatures are entering “uncharted territory,” climate scientists say

Sea surface temperatures in late June reached nearly 70 degrees Fahrenheit on average, shattering records

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Jul 1 • 3:44 PM EDT • Science • scientificamerican.com
Trump made $1.2B through crypto in 2025. Jonathan Swan says that likely doesn’t ‘scratch the surface’ of the family’s gains
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Jul 1 • 1:47 PM EDT • Politics • cnn.com
Rumor: Metroid Ravenous leaked for Nintendo Switch 2

Metroid Ravenous has apparently been leaked for Nintendo Switch 2. A listing for the game supposedly surfaced within Brazil’s Ministry of Justice and Public Security system. The page has already been removed, but not before a screenshot was taken. Here’s a snapshot of the classification: The listing doesn’t provide any specific details about the game. However, the classification indicates 2026...

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Jul 1 • 12:49 PM EDT • Technology • nintendoeverything.com
Google Pixel Watch 5 seemingly surfaces with four variants and even more questions

As another year goes by since the last Pixel hardware launch, the Pixel Watch 5 is beginning to surface online...

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Jun 29 • 12:09 PM EDT • Technology • 9to5google.com
Concerns with the Sebastian County Sheriff’s office

The recently-surfaced video showing the potential maltreatment of a Sebastian County Jail inmate, and a subsequent statement about the troubling incident from interim Sheriff Mike Conger point to the need...

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Jun 28 • 5:25 PM EDT • Politics • talkbusiness.net
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Galaxy Z's days are apparently numbered: Accessories point to a very unusual name for Samsung's iPhone Ultra competitor

At first, it was called the Galaxy Z Wide Fold or the Galaxy Z Fold 8 Wide, then—according to generally reliable sources—simply the Galaxy Z Fold8. Now a fourth name has surfaced for the compact and wider iPhone Ultra alternative, that Samsung will unveil on July 22 alongside the updated Galaxy Z Fold 8 Ultra. However, as authentic as these images seem to be, there are doubts.

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Jun 28 • 1:33 PM EDT • Technology • notebookcheck.net
EXCLUSIVE: Three Candidates Vying For Global Fund Leadership In Contentious Race

As the Global Fund heads into a secretive but highly contentious election of its new Executive Director, the names of three likely US candidates have surfaced - former Global Fund Executive Director Mark Dybul, former Trump appointee William Steiger and a former NYC public health official, Ashwin Vasan.

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Jun 28 • 12:51 PM EDT • Health • healthpolicy-watch.news
Yellowstone’s supervolcano may be fueled by something unexpected

Scientists have uncovered a new explanation for what powers Yellowstone and other supervolcanoes. Instead of a deep plume rising from near Earth’s core, a broad “mantle wind” may push hot rock beneath Yellowstone, generating magma closer to the surface. This process helps create a massive underground magma network and may explain how supervolcanoes remain active for long periods.

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Jun 27 • 8:00 AM EDT • Science • sciencedaily.com
MAI-Code-1-Flash for Copilot Business and Copilot Enterprise

MAI-Code-1-Flash, Microsoft AI’s in-house coding model, is now generally available for GitHub Copilot Business and Copilot Enterprise, building on its recent expansion across Copilot surfaces. Purpose-built for coding and optimized…

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Jun 26 • 12:35 PM EDT • Business • github.blog
How to get free Windows 10 security patches until October 2027 - and avoid the $30 fee

Don't want to pay to keep Windows 10 security updates? Microsoft has several workarounds, with the best deal for European users.

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Jun 26 • 8:34 AM EDT • Technology • zdnet.com
Scientists stunned by signs of ancient life in a place no one expected

Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.

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Jun 26 • 8:00 AM EDT • Science • sciencedaily.com
Scientists find evidence of vast hidden magma systems inside Mars

Researchers from the University of Oxford have uncovered evidence that Mars once hosted enormous, Earth-like magmatic systems deep beneath its surface—despite the planet lacking the plate tectonics long ...

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Jun 26 • 5:00 AM EDT • Science • phys.org
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street

Corporate dark money groups are funneling millions into eleven different races statewide.

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Jun 25 • 10:27 PM EDT • Politics • sentinelcolorado.com
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Video of Tom Sandoval pushing ex's dad into firepit surfaces

Bravo alum Tom Sandoval is in the midst of another controversy after video surfaced showing an altercation with his ex and her father.

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Jun 25 • 7:37 PM EDT • Entertainment • centraloregondaily.com
Making Our Own Luck

We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.

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Jun 25 • 4:48 PM EDT • Science • goodscience.substack.com
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Athlon Sports picks Bengals to resurface an old, heartbreaking trend

Would this be enough for Zac Taylor to get another season as the Bengals head coach?

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Jun 25 • 7:05 AM EDT • Sports • cincyjungle.com
Athlon Sports picks Bengals to resurface an old, heartbreaking trend

Would this be enough for Zac Taylor to get another season as the Bengals head coach?

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Jun 25 • 7:05 AM EDT • Sports • sports.yahoo.com
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Microsoft introduces cheaper Surface devices with half the memory

The 12-inch Surface Pro now starts at $849, while the 13-inch Surface Laptop costs $949 and up. Both start with 8GB of RAM instead of 16GB.

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Jun 24 • 5:39 PM EDT • Technology • theverge.com
Celtics' star Jaylen Brown's future remains murky

His name surfaced in trade talks for Giannis Antetokounmpo, who was ultimately traded to the Miami Heat. Boston's offer, including Brown and draft picks, wasn't enough to top Miami's.

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Jun 24 • 7:35 AM EDT • Sports • spectrumlocalnews.com
Microsoft relaunches 2025 Surface Pro and Laptop with half the memory, but at higher prices than original 16GB models

Microsoft is now selling cheaper Surface Pro 12-inch and Surface Laptop 13-inch configurations with 8GB of RAM.

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Jun 24 • 7:21 AM EDT • Technology • videocardz.com
Microsoft releases smaller Surface Pro with cheaper price and 90 Hz display

Microsoft has released a new Surface Pro 2-in-1. Smaller than the new Surface Pro 12 that features a 13-inch display, the updated Surface Pro 12-inch features a 90 Hz display and a Snapdragon X Plus chipset, but only 8 GB of RAM.

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Jun 23 • 9:14 PM EDT • Technology • notebookcheck.net
Microsoft releases new 13-inch laptop globally with cheaper starting price

Microsoft has released a new version of its Surface Laptop 13-inch. Sold globally, the updated Surface Laptop 13-inch is much cheaper than Microsoft's existing models. Sadly, the device achieves a $200 saving by returning to 8 GB of RAM.

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Jun 23 • 9:07 PM EDT • Technology • notebookcheck.net
Scientists Finally Find Out Why Gold Never Rusts Like Other Metals

Gold’s pristine shine may depend on an until now hidden atomic rearrangement at its surface.

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Jun 23 • 6:50 AM EDT • Science • zmescience.com
Earth’s mantle may be hiding an ocean’s worth of water 410 miles down - Futura-Sciences

An estimated 4.4 billion years ago, a series of planetary collisions delivered the vast majority of Earth’s water budget to a world whose surface was still a bubbling, glowing ocean of molten rock. As this global magma ocean slowly cooled and crystallized over millions of years into the planet’s first...

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Jun 22 • 9:00 AM EDT • Science • futura-sciences.com
World Cup brings political issues to the surface: 5 takeaways

The first week of the FIFA World Cup has been underscored by tensions over geopolitics, U.S. immigration policy and dramatic group stage action that is priming viewers around the world for what pro…

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Jun 20 • 6:00 AM EDT • Politics • thehill.com
Republican U.S. Senate Candidate visits Marquette County west end business

Republican Candidate Mike Rogers visited Robbins Sports Surfaces in Ishpeming Friday afternoon

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Jun 19 • 10:07 PM EDT • Business • uppermichiganssource.com
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Wealth management firm is the latest to announce a new Towne Center location

Merrill Lynch Wealth Management, a Bank of America company, plans to open a new location in Towne Center. Media reports surfaced early Friday that Bank of America would open its first Louisiana bra… Already an INSIDER? Sign in. Already an INSIDER? Sign in

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Jun 19 • 3:57 PM EDT • Business • businessreport.com
Watching water nanodrops spread themselves thin

Researchers at the Institute of Industrial Science, The University of Tokyo, have determined the molecular origin of line tension for a water nanodroplet on a surface. This tension is the force along the droplet edge where liquid, solid, and gas phases meet. Computational studies showed that at complete wetting, collapse of tetrahedral order in liquid water causes the line tension to change sign. An ice bilayer did not wet a hydrophilic surface, showing that local order can outweigh surface chemistry.

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Jun 18 • 8:00 PM EDT • Science • eurekalert.org
Philips Hue Adds Play Table Lamp, Floor Lamp, and New Candle Bulbs

Signify today announced two new Philips Hue devices to expand its Hue Entertainment lineup, debuting the Philips Hue Play Table Lamp and the Philips Hue Play Floor Lamp Large. There are also new candle bulbs. The two lamps are similar to the existing Signe Hue table and floor lamps, featuring a tall, linear design that casts light on a wall or surface behind the light.

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Jun 18 • 2:57 PM EDT • Technology • macrumors.com
Dem Senate hopeful under fire for resurfaced comments calling cops 'opportunistic cowards'

Graham Platner's anti-law enforcement Reddit posts resurfaced as the far-left populist seeks to unseat Sen. Susan Collins in Maine's Senate race.

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Jun 18 • 12:05 PM EDT • Politics • foxnews.com
GTA 6 Gameplay Leak Surfaces Ahead Of Trailer 3

Grand Theft Auto VI is closer to release than ever before, and the leaks continue to appear ahead of its arrival.

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Jun 18 • 5:31 AM EDT • Technology • screenrant.com
El Niño Is Underway

Satellite observations of sea surface height indicated that the 2026 event continued to strengthen in early June.

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Jun 18 • 12:00 AM EDT • Science • science.nasa.gov
FSU scientists uncover differences in drivers of long-term temperature changes in Atlantic, Pacific oceans

Florida State University researchers have identified key differences in the root causes of long-term sea-surface temperature changes across the Atlantic

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Jun 17 • 8:10 AM EDT • Science • news.fsu.edu
“This has never been seen before”: the mind-blowing discovery made by this deep-sea squid - Futura-Sciences

A Scene Never Seen The moment was caught by researchers using a remotely operated underwater vehicle (ROV) at approximately 13,450 feet (that’s about 4,100 meters) below the surface, in the Clarion-Clipperton Zone (CCZ) – a vast abyssal plain in the Pacific, now at the center of deep-sea mining ambitions. The...

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Jun 17 • 7:30 AM EDT • Science • futura-sciences.com
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2026 World Cup billed as ‘largest entertainment attack surface in history’

As the tournament is underway across North America, Palo Alto Networks warns that temporary supplier ecosystems, vulnerable municipal infrastructure, and geopolitical tensions are creating risks fo...

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Jun 16 • 10:25 PM EDT • Entertainment • computerweekly.com
Superconductivity breakthrough could unlock ultra-efficient electronics

A clever nanoscale redesign may have solved one of superconductivity’s biggest problems. Researchers in Sweden discovered that by subtly sculpting the surface beneath an ultrathin superconducting material, they could make it stay superconducting at higher temperatures and under much stronger magnetic fields.

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Jun 16 • 8:00 PM EDT • Science • sciencedaily.com