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Democrats’ long-shot bid to flip Alaska’s Senate seat
Democrats are hoping for an upset in Alaska’s Senate race. U.S. Rep. Mary Peltola, a Democrat, is trying to unseat Republican incumbent Sen. Dan Sullivan. We discuss the major issues at play, plus why Republicans are backing an effort to repeal Alaska’s ranked-choice voting system.This episode: voting correspondent Miles Parks, senior political editor and correspondent Domenico Montanaro, and Alaska Public Media Washington correspondent Liz Ruskin.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye.Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
Could U.S. pushback on foreign data laws recast global business operations?
Because of what's happening in the world today, the question becomes, can you really trust your trading partners?" Robert Cruz said.
AccuWeather is now available inside ChatGPT
Never again will you have to exit your AI app to check the forecast.
Apple launches iOS 26.4 with AI playlists, purchase sharing, and more
You can now ask Apple Music to generate a playlist based on a description.
Episode 68, Science for Success, Tissue testing and Potassium
By Dusty Sonnenberg, CCA, Field Leader, a project of the Ohio Soybean Council and Soybean Check-off In Episode 68, Dusty visits with soybean researchers involved in the Science for Success program. Science for Success provides timely, cutting-edge best management practices by coordinating the uni
TDN Business Hour: The Global Thoroughbred Market
Mark Taylor, Marshall Gramm, Anthony Trimarchi and Case Clay join the TDN Business Hour podcast hosted by Najja Thompson.
‘Scooby Doo Live Action’ Netflix Series Casts Paul Walker Hauser
Plus, everything you need to know about the upcoming series.
“SNL” alum calls out cast members who break into laughter during sketches: 'It doesn't work'
Kevin Nealon doesn't seem to be a fan of the recent Ryan Gosling episode.
'SNL' alum calls out cast members who break into laughter during sketches: 'It doesn't work'
Former 'Weekend Update' anchor Kevin Nealon isn't a fan of 'SNL' cast members breaking during sketches.
Trump casts Florida ballot by mail as he pushes Congress to severely limit that voting option
Trump has in the last week called mail-in voting "cheating" and "corrupt as hell" as he urges Congress to pass the SAVE Act, a sweeping bill that would bar universal mail ballots.
Entertainment lineup announced for Red River Valley Fair
WEST FARGO (KFGO) - The Red River Valley Fair just announced the 2026 grandstand entertainment lineup, bringin...
‘Healthy Rounds’: Dealing With Dementia
Dr. Kristina Zdanys, geriatric psychiatrist in the UConn Center on Aging, joins Dr. Anthony Alessi’s podcast
Trump casts Florida mail ballot as he pushes Congress to severely limit that voting option
President Donald Trump has cast another mail ballot in Florida as he continues to publicly bash the voting method as a source of fraud and push Congress to curtail the practice
UCLA Health podcast shines a light on colorectal cancer prevention, early detection and rising risks
UCLA Health's podcast episode on colorectal cancer, featuring Dr. Eve Glazier, Katie Couric and Dr. Fola May, highlights the critical need for prevention and early detection amid rising risks, particularly among younger adults. The discussion focuses on cancer screening, lifestyle modifications and advocacy to reduce the incidence of this disease.
Josh Shapiro endorses James Malone in key Lancaster County Senate race
Gov. Josh Shapiro has officially endorsed James Malone’s bid for reelection in the Lancaster County state Senate district that both parties say could determine party control next year.
India’s March private business activity slows to lowest since Oct 2022, missing forecasts
India's private-sector business activity, which had been on an upswing since the start of 2026, falters in March due to shockwaves from the Iran war
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Trump casts mail ballot in Florida even as he calls the method 'cheating'
The president cast a mail ballot in an upcoming Florida special election, according to county records.
Detroit Tigers' Opening Day be on cable TV? Here's what we know
The Detroit Tigers haven't been able to give details on their broadcast service, Detroit SportsNet, and its status on cable TV packages.
UFL 2026: Joel Klatt, Curt Menefee Return To Headline FOX Broadcast Team
Joel Klatt and Curt Menefee will once again lead FOX Sports' broadcast coverage for the highly anticipated third season of the UFL.
Science Through Shadows: How Astronomical Alignments Reveal the Universe
When one celestial object passes in front of another, it can cast a shadow that travels across space – and sometimes across Earth. These moments of alignment, known as eclipses, occultations, and transits, allow scientists to study distant objects in remarkable ways. By observing how light changes when an object briefly blocks another, astronomers can measure sizes and shapes, detect atmospheres, and refine the orbits of asteroids and planets.
Manor Township Democratic committee person kicked off May 19 primary ballot
Kirk Barrett, a candidate for a Manor Township seat on the Lancaster County Democratic Committee, has successfully kicked the incumbent’s name off the ballot for the upcoming May 19 primary.
Seattle Sports This Week: TV and radio for March 23-29
A look at the broadcast schedule for March 16-22 on Seattle Sports 710 AM and the Seattle Sports app, as well as local sports teams on TV.
Trump sued by historic preservation groups to block Kennedy Center changes
A coalition of preservation groups is suing to stop major physical changes at the Kennedy Center under President Donald Trump’s renovation plans. On Monday, the groups filed a lawsuit against
'Harry Potter' star details racist 'abuse' he suffered after joining upcoming TV show
Paapa Essiedu is speaking out about on 'abuse' he's endured since being cast as Severus Snape in the 'Harry Potter' TV series: 'Nobody should have to encounter this for doing their job.'
Khloé Kardashian Recalls How Her Divorce from Lamar Odom Made Her ‘Obsessed’ with Leading a Healthy Lifestyle
Khloé Kardashian opened up about her relationship with diet and exercise on the March 18 episode of her podcast, ‘Khloé in Wonder Land.’ She said she became ‘obsessed’ with exercise after examining how her food choices were affecting her quality of life.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
What’s happening in Vegas arts entertainment this spring
Festivals, concerts, sporting events and more: Make plans with our entertainment calendar.
\'Saturday Night Live UK\' aims to take a comedy hit across the pond. The first verdicts are in
A British version of “Saturday Night Live” has debuted to largely positive reviews. The first episode of “SNL UK” was hosted by Tina Fey, a veteran of the American show,
Lancaster County public sales: March 22, 2026
Beiler-Campbell Auction Services conducted a public auction of real estate March 9 for Stanley and Debora Miller at 2788 N. Colebrook Road, Manheim. A four-bedroom house with attached garage and
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026
Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]
The Supreme Court Could Make it Harder to Vote by Mail in the Midterms
The Republican National Committee wants to toss ballots arriving after Election Day. Critics say thousands of votes — a majority cast by Democrats — are at stake.
EA-US Politics Podcast: Mr Trump Goes to War
50-minute analysis of the chaos and destruction of Donald Trump and his inner circle as self-declared "President of Peace" wages war on Iran
Slovenians head to polls in tight race marked by spy scandal
Allegations of espionage and foreign interference have cast a shadow over the parliamentary election
Shame on ABC for casting Taylor Frankie Paul on 'The Bachelorette' — they're getting what they deserve
Giants' Cam Skattebo says CTE and asthma are fake, calls them an 'excuse'
New York's running back made headlines for his podcast comments on CTE and asthma
Farmers and rural community members can access free mental health resources
KGAN CBS 2 and KFXA Fox 28 provide local news, weather forecasts, notices of events and items of interest in the community, sports and entertainment programming for Cedar Rapids and nearby towns and communities in the Corridor and throughout eastern Iowa, including Iowa City, Waterloo, Dubuque, North Liberty, Coralville, Marion, Morengo, Williamsburg, Washington, Tiffin, Tipton, Solon, Mount Vernon, Lisbon, Central City, Urbana, Independence, Manchester, Dyersville, Oelwein, Cedar Falls, Waverly, Evansdale, Guttenberg, West Union, New Hampton, Decorah, Waukon, Maquoketa, Sigourney, Fairfield, Grundy Center, La Porte City, Dysart, Fayette, Elkader, Strawberry Point and Belle Plaine.
Manheim Township grad shines a light on nurses in documentary series
When she was 13 years old, Lancaster native Carolyn Jones gave up her violin for a Pentax 35 camera.
Microsoft is ending the Windows Update nightmare — and letting you pause them indefinitely
Pause updates “for as long as you need.”
Agnes Pockels’ pioneering work was unfairly dismissed by tropes about women’s domestic roles
Agnes Pockels achievements in surface science have long been overshadowed by a popular and likely untrue story that she became interested in the subject while doing the dishes
From corporate trailblazer to inspiring professor - Gary W. Rollins College of Business
From Turner Broadcast to corporate consulting, Libby Fakier is using her experience to build the next generation of professional sales.
British Airways and Audible take in-flight entertainment to new heights with brand-new audiobook and podcast offerings
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Influencers are pushing out media for aspiring Democratic politicians
Voters used to say they wanted a president they could have a beer with. Now, would-be presidential candidates are chasing that authenticity in a different way: appearing on podcasts, spo…
Fowler College of Business names founding director of ‘real-world’ lea
Professor Iana Castro will head the Shaw Family Center for Experiential Learning
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Verdict on Chatbots in Mental Health Screenings? Too Judgmental
Chatbots used in mental health screenings aim to reduce the stigma associated with seeking help and to expand access to needed services. Because they cannot cast personal judgment, chatbots are considered a neutral option for sharing mental health concerns. In a recent test of these common assumptions, however, a University of Texas at Dallas researcher […]
ABC cancels \'Bachelorette\' season with Taylor Frankie Paul, citing 2023 video
ABC has canceled its already filmed season of “The Bachelorette” starring Taylor Frankie Paul after a 2023 video surfaced. On Thursday, Disney Entertainment Television said was focused on supporting the
AEO Engine Launches ’AEO Engine AI Search’ Podcast – First Show Dedicated to How AI Is Reshaping Business Discovery, Search Visibility, and Brand Trust
AEO Engine logo representing the launch of the new "AEO Engine AI Search" podcast, hosted by Aria Chen and focused on
Joe Kent's resignation over Iran war reignites antisemitism fears and debate over Israeli influence
It was no surprise when Joe Kent showed up on Tucker Carlson’s podcast a day after quitting his counterterrorism job in President Donald Trump’s administration. But before long, the conversation moved in a different direction as Kent nodded to conspiracy theories that pro-Israel forces were behind the assassination of conservative activist Charlie Kirk.
‘It’s time to be honest’: Mark Robinson to discuss political defeat, allegations in new interview
In an episode of a new podcast called After The Call, former Lt. Gov. Mark Robinson is expected to focus on ‘setting the record straight on the controversies that surrounded his campaign.’
True Bill Talk: Prosecution & Politics
The March 14 episode of True Bill Talk shifts the podcast’s focus from its typically local level to a national one. Nelson Bunn is the Executive Director of the National District Attorneys Association (NDAA), an organization that influences the policies of thousands of prosecutors across the country. In a conversation with host Alissa Marque Heydari, […]
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
RFK Jr. Makes Food Sound Like a Miracle Drug. Researchers Say He Often Overstates the Science
In the Trump administration’s campaign to promote healthy eating, Robert F. Kennedy Jr. has not stopped at his slogan urging people to “eat real food” to prevent disease. In recent speeches and podcast appearances, the nation’s health secretary also has claimed that diet can “cure” schizophrenia and ...
German Health Minister Nina Warken and WHO Hub in Berlin highlight 2025 achievements
Germany’s Federal Minister of Health, Nina Warken, visited the WHO Hub for Pandemic and Epidemic Intelligence in Berlin today to review progress and launch its 2025 Annual Report. The report highlights advances in using artificial intelligence, data science and pathogen genomics to strengthen global preparedness for future pandemics.In 2025, the WHO Hub in Berlin worked with more than 160 Member States and over 190 partners to help countries and organizations develop new systems and tools to detect and understand new public health threats as quickly as possible, whenever and wherever they occur.BMG to confirm whether they wish to contribute a quote. “Detecting outbreaks early is one of the most effective ways to save lives and prevent epidemics from becoming global crises,” said Federal Minister of Health Nina Warken. “Germany is proud to host and support the WHO Hub for Pandemic and Epidemic Intelligence. Its work strengthens our safety at home and helps protect people worldwide.”Artificial intelligence is increasingly transforming the detection of outbreaks. In 2025, the Hub launched an upgraded version of the Epidemic Intelligence from Open Sources (EIOS) system, which uses enhanced AI functions to scan global online information in real time and help experts quickly identify unusual health events. The system is now used by 120 countries.To better anticipate health threats, countries need information beyond traditional health data. The Hub supports countries in implementing Collaborative Surveillance, which integrates data on climate, animals, travel, and population movement to provide a more comprehensive and real-time understanding of health threats.The Hub also expanded global access to pathogen genomics, which helps scientists detect new pathogens, such as viruses and bacteria, understand how they spread and how dangerous they may become. Through the International Pathogen Surveillance Network (IPSN), the WHO Hub in Berlin worked with 309 partners in 101 countries to expand access to these technologies.“We are in a new era of global health threats, and we need new tools to face tomorrow’s challenges,” said Dr Chikwe Ihekweazu, Executive Director of the WHO Health Emergencies Programme. “The WHO Hub in Berlin helps countries use data and technology more effectively so they can identify risks earlier and respond faster. No country can address these threats alone. Strong cooperation remains our best defence.”“Berlin offers an ideal environment for our work. We collaborate closely with world-leading institutions such as the Robert Koch Institute and the Charité Center for Global Health,” said Dr Oliver Morgan, Head of the WHO Hub for Pandemic and Epidemic Intelligence. “Germany has supported the WHO Hub since its establishment, and we are pleased to welcome Federal Minister Nina Warken to the Hub today. This strong partnership helps us advance innovation in pandemic and epidemic intelligence and better support countries to prepare for future health threats.”The Hub is expanding the use of advanced analytics and mathematical modelling to forecast how outbreaks may develop and to assess which response measures are most effective. Through its Collaboratory, the Hub connects modelers and analysts with governments to ensure their work addresses real public health needs. In 2025, the community grew to 1300 members from 50 countries and 200 institutions. An AI-powered pandemic simulator, currently in the prototyping phase, will help decision-makers compare outbreak scenarios and help identify effective disease control measures.
Nextdoor Promotes Tony Castellanos to Executive Vice President, People as AI-Driven People Strategy Becomes Core to Business Growth
SAN FRANCISCO, March 19, 2026--Nextdoor Holdings, Inc. (NYSE: NXDR), the essential neighborhood network, today announced the promotion of Tony Castellanos to Executive Vice President, People. Castellanos will lead Nextdoor's People organization — including talent acquisition, compensation, HR business partnering, and benefits — as the company deepens its investment in AI-enabled People operations and continues to scale its workforce strategy.
Should R.I. regulate private equity in health care after crisis at safety-net hospitals?
On the R.I. Report podcast, a Salve Regina University expert talks about what Massachusetts, Maine, and Oregon have done to control private equity and protect patients.
Rangers looking at Just
Rangers are keeping tabs on Motherwell's Elijah Just - with Celtic also keen on the New Zealand playmaker. Daily Record) Rangers are set to find it difficult to sign Wolves loanee Nasser Djiga permanently this summer because he has a contract until 2030 and could command a sizeable asking price. Football Insider) Rangers icon Barry Ferguson has let slip in a podcast that goalkeeper Liam Kelly, the 30-year-old who signed a two-year deal in 2024 after leaving Motherwell, has signed a contract extension at Ibrox.
How Barcelona exploited Magpies' defensive weakness
Champions League Match of the Day pundits Stephen Warnock and Nedum Onuoha look at how Barcelona were able to repeatedly expose Newcastle United's centre-backs Dan Burn and Malick Thiaw during their 7-2 victory in the second leg of their last-16 tie.
Braves News: Didier Fuentes dazzles, broadcast crew announced, more
Atlanta Braves news and notes from Wednesday
Zach Braff was mortified when Michael Fassbender mistook him for Dax Shepard in Vegas nightclub
Zach Braff is still mortified after being mistaken by a spirited Michael Fassbender for Dax Shepard in a packed Vegas nightclub. 'I was so embarrassed,' he confessed to on his look-a-like's podcast.
Takeaways from former Trump administration counterterrorism chief Joe Kent’s extensive interview
Former US National Counterterrorism Center Director Joe Kent sat Wednesday for an extensive interview with former Fox News host and right-wing podcaster Tucker Carlson, his first public comments since he resigned from his post, citing concerns about the war with Iran.
Champions League results: Liverpool, Bayern Munich comfortably advance; Barcelona routs Newcastle
Liverpool will meet PSG and Bayern Munich will take on Real Madrid in the quarterfinals.
Champions League scores: Live updates as Barcelona face Newcastle, Liverpool, Tottenham Hotspur in action
All six English teams entered this week after going winless in the first leg, with only Arsenal booking a spot in the quarterfinals so far
GOP candidate cites ‘failure’ of Newsom, Dems as new poll shows Republicans leading crowded California field
Steve Hilton, a Republican running for governor, said that the “absolute failure" by California Gov. Gavin Newsom and Democrats means that the GOP has a real shot at victory this year.
Revealed: a crypto billionaire’s political base hosting ‘anti-woke’ and rightwing activists in Westminster
Pardoned by Trump after violating US banking law, Ben Delo provides funding, networking, and podcasting space for a range of groups, including those with hardline views on migration and abortion
Texas primary results showed limitations of polling
Many factors explain why pollsters face challenges in getting good sample sizes that truly reflect who is going to cast a ballot.
Protalix BioTherapeutics Reports Fiscal Year 2025 Financial and Business Results
Company to host conference call and webcast today at 8:00 a.m. EDT The European Commission (EC) approved the 2mg/kg every-4-weeks (E4W) dosing regimen for...
Protalix BioTherapeutics Reports Fiscal Year 2025 Financial and Business Results
Company to host conference call and webcast today at 8:00 a.m. EDT The European Commission (EC) approved the 2mg/kg every-4-weeks (E4W) dosing regimen for...
7 events in Lancaster County this weekend, from a plant shop reopening to Zenkaikon
Spring starts this Friday, and there are plenty of ways to celebrate its arrival through the arts scene in Lancaster County this week.
VT Markets and Newcastle United Clinch Double Wins at Forex Sports Awards 2026
VT Markets, a leading global multi-asset broker, has been honoured with the prestigious "Best Global Football Sponsor - Newcastle United F.C" and "Best Commercial Spot - Together, Into Tomorrow" awards at the Forex Sports Awards 2026. The double accolades recognises the brand's high-impact partnership with Newcastle United, celebrating excellence in global brand alignment and fan engagement.
Judge Orders Voice of America to Restart All News Operations
More than 1,000 full-time journalists and support staff at the news group were ordered to return to work by March 23 and to resume broadcasting.
11Alive
WXIA (Atlanta) — 11Alive is your source for breaking news, Georgia weather, traffic, and live coverage in Atlanta and across the metro area. Get the latest updates from the 11Alive team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Atlanta, Marietta, Sandy Springs, Decatur, and surrounding communities. Subscribe for: • Atlanta breaking news + live updates • Georgia weather forecasts, storms, and severe weather alerts • Investigations and accountability reporting • Community stories across the metro area • Major events, sports, and local explainers WXIA / 11Alive — Atlanta news and weather, live and on demand. 🔗 More: https://www.11alive.com
Irish dancers bring St. Patrick’s Day celebrations to Lancaster venues [photos]
Irish dancers from the Doherty Petri School of Irish Dance (formerly known as the Paloma School of Irish Dance) could be found celebrating St. Patrick's Day at several bars and
The race for a safe Democratic House seat offers clues about the party’s future
It’s Primary Day in Illinois, where 15 Democrats, spanning three generations, are vying to succeed longtime Congresswoman Jan Schakowsky in the state's 9th Congressional District. We discuss what the race tells us about the future of the Democratic Party.This episode: senior White House correspondent Tamara Keith, political reporter Elena Moore, and senior political editor and correspondent Domenico Montanaro.This podcast was produced by Casey Morell and Bria Suggs, and edited by Rachel Baye. Our executive producer is Muthoni Muturi.Listen to every episode of the NPR Politics Podcast sponsor-free, unlock access to bonus episodes with more from the NPR Politics team, and support public media when you sign up for The NPR Politics Podcast+ at plus.npr.org/politics.
Miami Cubans Fear Trump Won’t Go Far Enough: ‘The Castros Have to Go’
Many Cubans in Florida have sought regime change for decades. They fear that President Trump’s talks with Cuba will not lead to wholesale political transformation.
Cibus Reports Fourth Quarter Financial Results and Provides Business Update
SAN DIEGO, March 17, 2026 (GLOBE NEWSWIRE) -- Cibus, Inc. (Nasdaq: CBUS) (the "Company"), a leading agricultural technology company that develops and licenses plant traits to seed companies, today announced its financial results for the quarter ended December 31, 2025, and provided a business update. Management will host a conference call and webcast today at 4:30 p.m. ET. Management Commentary Peter Beetham, Interim Chief Executive Officer of Cibus, commented, "2025 was a landmark year that val
DETROIT PISTONS PARTNERING WITH SCRIPPS SPORTS, TV-20 DETROIT TO BROADCAST FIVE GAMES OVER REMAINDER OF SEASON
The Detroit Pistons announced today that the organization will partner with Scripps Sports and FanDuel Sports Network Detroit for a third consecutive season
Barcelona star to return to starting XI vs Newcastle
A member of the defensive ranks at La Liga giants Barcelona is in line for a return to starting duties in the club’s next outing.That’s according to Diario Sport, who highlight Eric García as the...
WKYC Channel 3
WKYC (Cleveland) is your source for breaking news, Northeast Ohio weather, traffic, and live coverage in Cleveland and across the region. Get the latest updates from the WKYC team — from major local headlines and investigations to severe weather, community stories, and the moments everyone’s talking about. Watch live newscasts, stream breaking coverage, and catch up on the top stories shaping Cleveland, Akron, Canton, and surrounding communities. Subscribe for: • Cleveland breaking news + live updates • Northeast Ohio weather forecasts and severe weather alerts • Investigations and accountability reporting • Community stories across the region • Major events, sports, and local explainers WKYC — Cleveland news and weather, live and on demand. 🔗 More: https://www.wkyc.com/
UEFA Champions League expert predictions, picks: Can Chelsea, Manchester City or Tottenham stage a comeback?
Elsewhere in the round of 16, Liverpool have a one-goal deficit to overturn, while Arsenal and Newcastle are tied with Leverkusen and Barcelona 1-1
'Super El Niño' could push global temperatures to unprecedented highs, forecasters say
A "super El Niño" could emerge by the end of the 2026 hurricane season, with forecasters predicting that the ongoing La Niña is about to finish.
How Mizzou is helping mentor the next generation of sports broadcasters
This semester, John Anderson is sharing his industry insights, connections and experience in play-by-play announcing and sports broadcasting with Missouri School of Journalism students.
Stars deliver modern and colorful looks on Oscars red carpet
For Hollywood’s biggest night, celebrities pay as much attention to their speeches as to their red-carpet attire. It’s a night to leave a mark not just on Hollywood but on
Castlederg: Businesses say regeneration construction work impacting trade
Business owners in Castlederg say they are frustrated by the impact construction work is having on the town.
Yankees news: Rodón surprising himself in camp
Rodón showing good velocity in camp; Castro could become a name to watch for bullpen; Boone thinks Hess could make an impact.
Complete list of 2026 Academy Awards winners
“One Battle After Another” won several awards at Sunday's Oscars, including best picture, director and the first-ever casting award. “Sinners” star Michael B. Jordan, won best actor, earning his first
Norwegian family drama ‘Sentimental Value’ wins Oscar for best international film
“Sentimental Value” has won the Oscar for best international film. The family drama by Joachim Trier explores an estranged family’s wounds in when a director father, who repeatedly prioritized career
The Latest: ‘One Battle After Another’ takes best picture
The 98th Academy Awards on Sunday saw “One Battle After Another” win big with six awards, including best picture, director, supporting actor and casting. “Sinners” followed with four awards, including
\'One Battle After Another\' wins best picture at 98th Academy Awards
Paul Thomas Anderson’s “One Battle After Another” has been crowned best picture at the 98th Academy Awards. Jessie Buckley won best actress and Michael B. Jordan won best actor at
Norway\'s \"Sentimental Value\' wins at Oscars and \'Sinners’ cinematographer makes history
"Sinners” cinematographer Autumn Durald Arkapaw has made Oscar history, becoming the first female director of photography to win the award in the 98 year history of the Academy Awards. Paul
The Latest: The 2026 Academy Awards get underway
The wait in Hollywood is over: The 98th Academy Awards are underway. Comedian Conan O’Brien is back for a second year to host the ceremony on Sunday, held at the
\'KPop Demon Hunters,\' \'Frankenstein\' hand Netflix early wins at Academy Awards
The first ever Oscar for best casting went to Cassandra Kulukundis for “One Battle After Another.” “KPop Demon Hunters,” Amy Madigan and “Frankenstein” won early Oscars at a 98th Academy
Scientists just discovered a tiny signal that volcanoes send before they erupt
A new detection method called “Jerk” could dramatically improve how scientists forecast volcanic eruptions. By using a single broadband seismometer, the system can detect extremely subtle ground movements caused by magma pushing underground—often hours before an eruption begins. Tested for more than a decade at the Piton de la Fournaise volcano on La Réunion, the tool successfully predicted 92% of eruptions between 2014 and 2023, sometimes giving up to eight hours of warning.
LIST: School and business closings and delays for March 16, 2026
Several delays and closings are in place across our region as forecasts show severe weather is likely to impact parts of Virginia.
Politics Unplugged Podcast: Chuck Coughlin on the SRP election
Independent consultant Chuck Coughlin returns to the pod to talk about the SRP election and why not everyone can vote. Then Dennis, Colin and Arizona's Family film critic Hunter Norris preview the Oscars.
2026 NCAA Tournament Projections: Florida Still a No. 1 Seed? Miami (OH) In or Out?
FOX Sports' bracket forecaster Mike DeCourcy offers up his latest men's NCAA Tournament projections.
Animated ‘Firefly’ Series in Development With Original Cast Set to Return
‘Clearly, the return of Firefly is something the fans want,’ star Nathan Fillion said. ‘More importantly, it’s something they deserve.’
Bill Cassidy faces another MAHA fight with his reelection on the line
Louisiana Sen. Bill Cassidy in February weighed possible political peril against a long career in medicine, ultimately casting the critical vote to confirm known vaccine skeptic Robert F. Kennedy as the president’s Health and Human Services secretary.
Mitch Morse reveals new career journey after retirement
During his chat with @EdEastonJr, former Kansas City Chiefs center Mitch Morse revealed his new broadcast career journey after retirement from the NFL