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ACE WFM Strengthens Workforce System Delivery Approach for Australian Organisations
Melbourne, AUSTRALIA, June 29, 2026 (GLOBE NEWSWIRE) -- ACE WFM, a workforce management consulting provider, has outlined its structured approac...
Restructuring safety
The real question isn’t whether safety survives a restructuring; it’s where the cracks appear first – and whether anyone is looking.
Congress passes rare bipartisan bill on housing, how manufactured housing could be crucial to affordability
Multiple sclerosis affects social life and work beyond physical health
Multiple sclerosis (MS) can have a substantial impact on many aspects of life beyond physical health, with 51% of people reporting that the disease affects their social life and 48% reporting that it affects their work, according to new research presented at the European Academy of Neurology (EAN) Congress 2026.
Trump calls likely DC mayor Janeese Lewis George a 'communist' and vows to block her agenda
D.C. mayoral frontrunner Janeese Lewis George faces clash with President Trump over ICE enforcement, policing, cashless bail and sanctuary city policies.
I spent weeks thinking my Pixel's camera lens was smeared before discovering the real culprit
I can finally take good pictures again!
Why did this journal retract two 1940s papers by Max Planck?
Clicking on the links now reveals blank pages and empty PDFs. "Intellectually, it’s not acceptable.”...
Then and Now: Brandenburg manages through global uncertainty
For James Brandenburg, president of U.S. operations for JVS Export, a family-owned textile manufacturer headquartered in India, the hardest part of his job isn’t selling home textiles to Walmart, Target...
Los Alamos Faith And Science Forum Announces Schedule Of Lectures Through Aug. 12
Courtesy image/LAFSF Los Alamos Faith and Science Forum News: For 2026, the Los Alamos Faith and Science Forum invites the public to examine issues at the interface of faith and science on Wednesdays through Aug. 12. After a light dinner at 6 p.m., presentations will begin at 6:30 p.m. to be followed by a Q […]
‘Inner party turf wars’ hang over annual Florida Republican convention
Byron Donalds and state party chair Evan Power also detailed how they plan to frame Florida’s moderate Democratic candidates as progressives.
The PlayStation 6 Reportedly Already Costs $960 in Materials to Manufacture
The PlayStation 6 reportedly costs $960 to build in materials, suggesting next-gen consoles' prices could be much higher than anticipated.
International Business Machines (IBM) Is A Top Stock In Billionaire Richard Chilton’s Filings
International Business Machines Corporation (NYSE:IBM) is one of the 10 Best Stocks to Buy According to Billionaire Richard Chilton. Technology giant International Business Machines Corporation (NYSE:IBM) made a key announcement recently when it announced its 0.7-nanometer chip manufacturing technology. This technology is the most advanced chip manufacturing technology in the world. International Business Machines Corporation […]
After trying a Google TV projector, I may never buy another TV ever again
After spending a few weeks with a Google TV projector, I think I may be done buying actual TVs for good. Here's what changed.
Science says these 7 parenting beliefs may be quietly making life harder for parents and children
Every parent wants to give their child the best possible upbringing. But in trying to be the “perfect parent,” many may be putting unnecessary pressure on themselves. A 2023 survey of more than 700 parents by researchers at Ohio State University found that 57% reported experiencing parental burnout. Surprisingly, the biggest predictor wasn't the number of children they had or how many hours they worked- it was the pressure to live up to an impossible standard of parenting. Child development experts say many of the beliefs parents consider signs of “good parenting” may actually be making life harder for both parents and children. Here's what science says.Here are seven common parenting beliefs that science says may be working against both parents and children.
Tariffs continue to add uncertainty to business climate: Top Workplaces 2026
Companies like Gardiner HVAC in Solon are navigating fluctuating prices and supply chain disruptions as tariff policy remains volatile more than a year after implementation.
‘AIDS is not over:’ Behind a local group’s awareness campaign for HIV funding
Walk through East Liberty, Bloomfield or other Pittsburgh neighborhoods and you might see flyers with black-and-pink block print and an urgent message:...
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
Could 'humanmaxxing' actually help you live longer? Here's what experts say
Humanmaxxing is the latest wellness trend focused on maximizing human potential through biohacking, longevity science and advanced medical treatments.
A Giant Scorpion the Size of a Coffee Table Is Forcing Scientists To Rethink Evolution
Praearcturus gigas was a meter-long Devonian scorpion whose size may reflect a world with few large competitors rather than high oxygen alone.
Citing construction, downtown Noblesville business will close
The Velvet Plum Vintage & Consignment, a home decor and furniture consignment shop at 894 Logan St. in Noblesville, has announced it will close July 15, citing Embrace Downtown construction as the driving factor. The Embrace Downtown project began earlier this year to provide infrastructure a
Citing construction, downtown Noblesville business will close
The Velvet Plum Vintage & Consignment, a home decor and furniture consignment shop at 894 Logan St. in Noblesville, has announced it will close July 15, citing Embrace Downtown construction as the driving factor. The Embrace Downtown project began earlier this year to provide infrastructure a
McArthur Center to prepare University of Rio Grande health care and manufacturing students
A facility at the University of Rio Grande has opened, offering new educational opportunities for students.The McArthur Center features nine modern classrooms a
Is 10,000 Steps a Day Actually Based on Science? Here's What the Research Says
The 10,000 steps target came from a 1960s Japanese marketing campaign, not clinical research. Here's what the evidence actually supports about daily step counts, mortality risk, and what a realistic goal looks like for most people.
10 Game-Changing Entertainment Venues Designed by Populous
A look at 10 entertainment venues by Populous, spanning esports, concerts, and more, that are redefining audience experiences worldwide.
Anthropic's Mythos 5 gets limited carveout from US restrictions
Anthropic said it is restoring access to Mythos 5 for a set of US organizations that "operate and defend critical infrastructure."
"Playhouse For Predator": Epstein Used 'Fake' Science Office As Prison Escape
The Florida Science Foundation was presented as a legitimate organisation focused on supporting research. But a review by The Telegraph of more than 1,000 documents connected to the company painted a different picture.
How Trump’s takeover fractured America’s birthday party
When Next250 organizers began planning for America’s 250th birthday, they envisioned bringing together communities in a polarized country to celebrate democracy.
Illinois 250: What we’ve invented, innovated, created and manufactured
Illinois builds things. We invent and innovate, too — everything from the Pullman car to plastic party cups.
3 foods that seem healthy but may be bad for your heart: cardiologist
A cardiologist said popular "healthy" foods can actually be bad for your heart, since they're highly processed and full of additives like sugar and fat.
Why Kemba Walker is excited about Hornets’ future, 2026 NBA Draft additions
Charlotte’s player enhancement coach spoke to The Charlotte Observer during grand opening of The Kemba Walker Sports Academy in Concord.
CIAA extends commish, teases "playoff" format
The CIAA will keep a familiar face at the top while teasing a new format.
3 flagship Android phones are cheaper now than they were on day one of Prime Day, but not for long
Prime Day is nearly over, but these three flagship Android phone deals have actually improved since the sale started.
Tolle tries to tackle Yankees in Friday night clash
Can the momentum actually be kept up from last night’s win?
Moment of Science: Music and Color
Dr. Stefan Wienzierl at TU Berlin studies how the architecture of a classroom or concert hall can impact the quality of music or speech.
What is a doublet earthquake? The science behind twin tremors
Several of the world’s most destructive earthquakes were actually two or more tremors occurring in rapid succession
The 5-Question Org Chart Audit I Run Before Scaling AI Across a Business
AI success depends less on the technology and more on the organization behind it. These five questions help leaders identify the structural barriers that prevent AI from delivering real business impact.
$13 million in federal funding to be distributed across West Michigan clinics
More than $13 million in federal funding will be distributed across West Michigan hospital and clinic systems for research projects and healthcare infrastructure.
EA Sports College Football 27 Will Be Without Two Surprising Stars
One of the most anticipated video game releases of the year is set to arrive on July 9 when EA Sports releases College Football 27 worldwide.This marks the third consecutive annual release since the series returned after an 11-year hiatus.Players who want to be included in the game must actively opt in through a structured […] The post EA Sports College Football 27 Will Be Without Two Surprising Stars appeared first on HEAVY.
Honda Strengthens Power Sports & Products Business With More Unified Structure
American Honda announced a restructuring of its Power Sports & Products center, aligning its Powersports, Power Equipment and Marine divisions under a unified structure.
Manufacturing business cuts ribbon in Putnam County, set to bring 120 jobs to area
The operation is a joint venture between global engineering group Sandvik and mining company Alpha Metallurgical Resources.
What your sleep schedule says about your health
From the time you naturally wake up to how long you actually sleep, your schedule holds clues about your heart, hormones, mental health, and longevity
Why Your Nighttime Dreams Are So Weird—Science Finally Has the Answer - Futura-Sciences
The Secret Life of Dreams: Not Just Random Nonsense Remember the dream you had last night? Maybe you’re left with just a trace—a sweet feeling, maybe, or a strange discomfort. But there’s rarely a story you could actually retell. Because, in the end, a dream is a deeply personal experience....
Strictly Business Cannes Lions: Deloitte, AWS, Sony Execs on AI and Tech Adoption
Variety Strictly Business Podcast Live presented by AWS & Deloitte featured Deloitte's Michelle McGuire, AWS's Ruba Borno, and Sony Pictures Entertainment's Pete Wood.
Strictly Business Cannes Lions: Deloitte, AWS, Sony Execs on AI and Tech Adoption
Variety Strictly Business Podcast Live presented by AWS & Deloitte featured Deloitte's Michelle McGuire, AWS's Ruba Borno, and Sony Pictures Entertainment's Pete Wood.
Earthquake shifts political ground for Venezuelan leader Delcy Rodriguez
Venezuela's strongest earthquake in over a century is the biggest challenge to Delcy Rodriguez's leadership but could also allow the interim president to stamp her authority on a fractured government.
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Cutting costs to move forward: SoFi State of Small business 2026 survey
SoFi reports 86% of small business owners see growth or stability, yet 66% cite high costs, mainly inflation and interest rates, as major challenges.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Why Pollinators Matter for Human Health | Johns Hopkins Bloomberg School of Public Health
New research shows that wild insect pollinators play a critical role in nutrition and livelihoods.
Starlink veterans launch startup to broaden megaconstellation ownership
Former SpaceX engineers who helped build and scale Starlink have launched a startup aiming to deliver megaconstellations for governments and companies seeking more control over space-based infrastructure.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Nevada takes step toward becoming corporate litigation hub with business court pilot program
The Clark County District Court this week announced it has restructured its departments to include a dedicated business court. The restructuring is expected to bring down case adjudication times, and it could help an ongoing effort to transform Nevada into a premier destination for corporate litigation. Judges Maria Gall and Joe Hardy–Departments 9 and 15, […]
NC Democrats demand lower utility costs + budget talks drag on as deadline nears
Read our Under the Dome newsletter and listen to our Under the Dome podcast to stay up to date on #ncpol.
Bank of America community roundtable highlights sales tax increase, small business struggles
Business and government leaders also discussed hiring trends and the importance of the Charlotte Douglas International Airport.
Cabo Verde Is a Breakout Star of the World Cup. So Is the Family-Owned Business That Designed Its Jerseys
After more than three decades manufacturing apparel, Capelli Sport co-founder and CEO George Altirs found his company’s biggest billboard yet—3,500 miles away from his midtown Manhattan office.
The heatwave hacks that will actually help to keep you cool
Should you wear wet socks to bed or point a fan out the window? Can the ‘Japanese door fan’ technique cool a baking hot car? Here’s what the science says
It's Summer Sale Season, So I Tracked Down 25 Actually Good Gaming Deals Under $20
There's a million sales happening right now, so I sifted through them all to find 25 genuinely solid gaming deals that are each under $20.
Discussing progress in nuclear fuel and materials science
The NEA held the sixth annual week of collaborative meetings of the Working Party on Materials Science Issues in Nuclear Fuels and Structural Materials (WPFM) from 18-22 May 2026 at the NEA offices in Boulogne-Billancourt, France.
Health officials warn against swimming at Avocado Lake after elevated E. coli levels
Health officials are advising people to avoid swimming at Avocado Lake after elevated levels of E. coli bacteria were detected at the lake's swim beach.Accordin
M6 MacBook Pro Expected This Year With Apple's First 2nm Chip
Apple could launch an updated base model 14-inch MacBook Pro with an M6 chip as soon as this year, reports Bloomberg. There could also be M6 chip updates for the Mac mini, iMac, and MacBook Air, but Apple is testing an M6 MacBook Pro. Apple plans to introduce the M6 in late 2026, and for the first time, it will be a standalone chip. Apple is not working on M6 Pro or M6 Max chips, and will hold off on higher-end chip options until the M7 series launches in 2027.
Moore links Maryland primary to Mamdani-backed wins; analysts disagree
Gov. Wes Moore says Maryland’s primary election showed voters rejected the status quo, but political analysts say the results reflect a more complicated picture.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Who is Anuk Karunaratne? Meet the Cardinals’ new President of Business Operations
The St. Louis Cardinals formally promoted Anuk Karunaratne to the role of President of Business Operations on Wednesday as the franchise unveiled changes to its organizational leadership structure.
Scientists measure hidden quantum forces that could power a new generation of pharmaceutical drugs
It's one thing to design a pharmaceutical drug. It's another to know if and why it actually works; not on paper or in a computer model, but inside the chaotic world of living systems, where proteins twist ...
This week in science: Exoplanetary salt clouds, ancient families and laughter's origin
Hosts from NPR's science podcast Short Wave talk about an exoplanet with pink, salty clouds, the surprising social structure of ancient human relatives and the origins of laughter.
Roundup: Shift in NIL / BlackBerry transitions / Agriculture aid
More inclusive: A recent NCAA rule change is shifting name, image and likeness opportunities away from only the biggest star athletes to a wider range of student-athletes. The update gives schools more structured involvement in managing and facilitating NIL deals, which reduces some of the previous free-for-all environment. As a result, athletes who are not […]
Impact of European heat wave on transportation, businesses, tourism
A heat wave across Europe caused record-breaking temperatures, affecting businesses, infrastructure, and daily life.
That's 'Entertainment!': Q and A with Jon King of Gang of Four
Gang of Four stormed out of Leeds, England in 1976, rewiring punk rock with a Molotov cocktail of jagged guitar, danceable rhythms, and intellectual political critique. The group remains one
Scientists find molecular-level evidence for two structures in liquid water
A study published in Nature Physics provides new molecular-level evidence from simulations that liquid water is not a single uniform substance, but a constantly shifting mixture of two distinct microscopic ...
Prime Day Smartphone Deals Are Live: Save Up to 44% on Samsung Foldables, Google Pixels, Motorolas, and More
These are the Amazon Prime Day smartphone deals actually worth buying, featuring editor-approved picks from Samsung, Google, Motorola, and more.
Two NC lawmakers, a Democrat and a Republican, push Congress to delay SNAP changes
Above the federal penalty threshold, NC could owe $140M a year, putting at risk a program that helps over 1.2 million North Carolinians.
Semi-communal 'compound houses' in Ghana affect how people participate in political activity
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How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
Around the MHS
This edition of news from around the Military Health System for the week of June 22-26, 2026, includes a vital partnership between Offutt Air Force Base and the American Red Cross, new Uniformed Services University research on stress fractures, and Naval Medical Research Unit EURAFCENT participates in a multinational readiness exercise.
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KUSTOM ENTERTAINMENT, INC. ANNOUNCES BINDING AGREEMENT FOR THE DIVESTITURE OF ITS VIDEO SOLUTIONS SEGMENT TO FULLY COMPLETE LIVE ENTERTAINMENT PIVOT
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