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Central Florida Congressional races attract out-of-district candidates
After long-time U.S. Representative Daniel Webster announced his retirement in April, potential successors quickly filed to run for the open Central Florida seat. But of the eight major-party candidates who
Multiple sclerosis affects social life and work beyond physical health
Multiple sclerosis (MS) can have a substantial impact on many aspects of life beyond physical health, with 51% of people reporting that the disease affects their social life and 48% reporting that it affects their work, according to new research presented at the European Academy of Neurology (EAN) Congress 2026.
Drew Nesbitt captures first Korn Ferry Tour title at Memorial Health Championship presented by LRS
Charting the champion (stats updated through the tournament)
Buccaneers place two offensive leaders on CBS Sports Top 100 list
Tristan Wirfs and Baker Mayfield represented the Buccaneers on Pete Prisco’s CBS Sports Top 100 players list, highlighting Tampa Bay’s offensive core.
Justin Jefferson lands inside top 10 of CBS Sports Top 100 list
Justin Jefferson represented the Vikings near the top of Pete Prisco’s CBS Sports Top 100 players list, landing at No. 8 overall.
Efzimfotase alfa demonstrated improvements in bone health in treatment-naïve pediatric patients with hypophosphatasia achieving median difference of 1.67 vs placebo in RGI-C Score at week 25 in MULBERRY Phase III trial
Positive results from the MULBERRY Phase III trial showed that efzimfotase alfa (ALXN1850), an investigational enzyme replacement therapy, demonstrated a statistically significant and clinically meaningful improvement in bone health in children (2 to
Claims GTA 6 is selling 8 times as many copies on PS5 as Xbox "doesn't represent pre-order data", insists Microsoft
Microsoft has refuted claims that its rival system, the PlayStation 5, is outselling the Xbox edition of Grand Theft Auto 6 by a rate of 8-to-1.
‘Color Book’: An exquisite character piece
Strong performances anchor this memorable indie drama
PlayStation Plus Free Games July 2026: Predictions, Rumors, Leaks And More
PlayStation Plus free games for July 2026: predictions, rumors and leaks for PS Plus Essential, including possible PS5 and PS4 titles ahead of the official reveal.
Rep. Jahana Hayes released from hospital after health scare
Representative Jahana Hayes has been released from the hospital after a health scare last week. In a video posted to Facebook on Sunday, she said she was leaving St. Mary’s Hospital where she was admitted for the last two days. “On Friday, I felt like I was dizzy while shopping, I was out getting phones at the mall and felt…
Los Alamos Faith And Science Forum Announces Schedule Of Lectures Through Aug. 12
Courtesy image/LAFSF Los Alamos Faith and Science Forum News: For 2026, the Los Alamos Faith and Science Forum invites the public to examine issues at the interface of faith and science on Wednesdays through Aug. 12. After a light dinner at 6 p.m., presentations will begin at 6:30 p.m. to be followed by a Q […]
Rep. Ryan rejects rolling back of PFAS cleanup at Stewart air base
Pat Ryan, a Democrat who represents New York’s 18th Congressional District, says the Department of Defense is looking to reduce statutory reporting requirements for PFAS at military installations.
Ravens have 5 players on CBS Sports' Top 100, but one omission stands out
Lamar Jackson headlines Baltimore's representatives on CBS Sports; top 100 ranking, but Zay Flowers' absence is sure to spark debate.
‘Handmaid’s Tale’ Star Shares The Text Elisabeth Moss Sent After Trump Won — And Fans Will Recognize It
The actor recalled texting Moss, “What are we going to do? This can’t be.”
Mel Brooks turns 100: His 5 essential movies
As the legendary comedian and filmmaker marks his centennial, here's how to watch his best movies.
Mel Brooks turns 100: His 5 essential movies
As Mel Brooks turns 100 today, here are the 5 must-watch comedies from his hilarious canon of work.
Prescott, Parker present Cowboys with an 'iron sharpens iron' dynamic
Cowboys quarterback Dak Prescott has had issues solving two defensive schemes. With Christian Parker in the building, he may finally figure it out.
Americans now live longer in Democratic-held House districts. Here’s why
Even as health care issues rise in the 2026 campaign debate, new data show that far more House Republicans than Democrats represent districts where the most residents face major medical challenges — and lack health insurance.
Japan's workplace culture reshaped my expectations of work
Moving to Japan presented challenges in practices like gift-giving and limited sick leave, and reshaped what I expected from work.
Costs of Iran war will linger despite conflict's end, experts say
The effects of the war and other factors driving inflation are likely to stick around for months, experts say, presenting an ongoing challenge to American households.
Wimbledon 2026 preview: Serena Williams, Jannik Sinner, Novak Djokovic
Serena Williams, Jannik Sinner and Novak Djokovic feature in our essential guide to Wimbledon 2026.
Maryland health insurance rates could rise 13.7% in 2027 under proposal
BALTIMORE — Maryland residents who buy health insurance through the Affordable Care Act marketplace could see higher premiums next year, with insurers requesting an average rate increase of 13.7% for
World Cup Watch: Red Representation High in Knockouts
Liverpool will be well-represented in the Round of 32 at the World Cup.
Alzheimer’s research headlines 2026 brain health summit
The event featured presentations on recent Alzheimer’s advancements.
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities Pride, Breakaway, Broadway, concerts, festivals and family fun headline one of summer's biggest weekends across Minneapolis and Saint Paul.
Drew Nesbitt claims one-shot lead heading into Sunday at Memorial Health Championship presented by LRS
Charting the leader (stats entering week)
Senators, Pennsylvania businesses to represent Commonwealth at Great American State Fair
WASHINGTON, D.C. (WHTM) — Pennsylvania will be represented at the Great American State Fair after all. The Commonwealth’s delegation to the U.S. Senate announced a planned “strong…
You’ve never seen this before: the shocking moment the sound barrier breaks - Futura-Sciences
The XB-1 is a critical stepping stone toward commercial supersonic travel, representing the first civil designed aircraft to break the sound barrier since the Concorde retired. To verify the aircraft’s aerodynamic performance during its supersonic transition, NASA deployed an advanced optical technology called schlieren imaging to make the invisible forces...
Los Alamos Faith and Science Forum launches 2026 Summer Series - Lutheran Alliance for Faith, Science and Technology
The Los Alamos Faith and Science Forum's 2026 summer season is on, offering weekly presentations on humanity’s most enduring scientific and spiritual questions.
"This doesn’t represent pre-order data," Xbox disputes reports of PS5 crushing GTA 6 preorder demand
As rumors of a massive sales gap circulate, Xbox sets the record straight on why affiliate clicks are not the same as console sales.
"Playhouse For Predator": Epstein Used 'Fake' Science Office As Prison Escape
The Florida Science Foundation was presented as a legitimate organisation focused on supporting research. But a review by The Telegraph of more than 1,000 documents connected to the company painted a different picture.
Will Cannon posts second-round 61, leads Memorial Health Championship presented by LRS
Will Cannon grabs a one-shot lead through 36 holes at the Memorial Health Championship presented by LRS after posting a 10-under 61 on Friday.
National Science Foundation finds no violations in Texas A&M research security contract
U.S. Rep. John Moolenaar, a Michigan Republican who chairs the House of Representatives' select committee on China, had urged the NSF to pause funding for a project known as SECURE.
Trump news at a glance: president tests out a new ‘red scare’ ahead of midterms
Republican strategists believe rise of Mamdani could present opportunity to tag Democrats with most extreme views of the left – key US politics stories from Friday 26 June
Testing gives science-based data for Fairmont lakes
FAIRMONT— A partnership between the city of Fairmont and Minnesota State University-Mankato will result in comprehensive scientific data on the Fairmont Chain of Lakes. The $25,000 contract started on April 1 and will go through Dec. 31 of this year. Fairmont’s Water Resources Coordinator, Hannah Neusch, acknowledged that while the water treatment plant in Fairmont […]
Sarah Ferguson visited Epstein in jail twice amid email exchanges: Report
A new report suggests that Sarah Ferguson visited Jeffrey Epstein twice in 2009 during his first prison sentence in Florida.
But-For Causation and the Essential Business Hurdle: Analyzing the Summary Judgment in RAAM Construction
RAAM Construction Inc v. United States of America, Case No. 2:25-cv-04681-SPG-AJR, 2026 WL 18391 (C.D. Cal. June 23, 2026). The Employee Retention Credit (ERC) codified under Internal Revenue Code Section 3134 remains a significant source of controversy, audits, and high-stakes federal litigation.
This Week's 10 Must-Read Stories on Women in Politics: Title IX Anniversary, AI's Anti-Women Bias and Ranked-Choice Voting Victories
Weekend Reading on Women’s Representation is a weekly compilation of stories about women’s representation in politics, on boards, in sports and entertainment, in judicial offices and in the private sector in the U.S. and around the world—with a little gardening and goodwill mixed in for refreshment! Published every Friday. —This week marked the 54th anniversary of Title IX. —As the Taliban approaches the five-year mark of its return to power this August, a rare protest in western Afghanistan last week laid bare both the brutality of its rule and the resilience of those living under it. —A woman will replace Eric Swalwell in California … but for not two more months. —A study of 133 AI systems found that 44 percent demonstrated gender bias, and more than a quarter showed both gender and racial bias. ... and more.
Registration open for 2026 Behavioral Health & Children and Family Services Conference | Health and Human Services North Dakota
Registration is now open for the sixth annual Behavioral Health & Children and Family Services Conference, scheduled for Sept. 14-17 at the Bismarck Event Center and online through a livestream option.The main conference will take place Sept. 15-17, with optional pre- and post-conference sessions offered Sept. 14 and Sept. 17.More than 1,400 in-person attendees and hundreds of virtual participants are expected to take part in keynote presentations, breakout sessions and networking opportunities focused on behavioral health, child welfare, suicide prevention and youth development.
Supreme Court says Alito’s verbal reaction to Sotomayor was a ‘misunderstanding’ by Alito
The highly unusual exchange between Justice Samuel Alito and Justice Sonia Sotomayor over a dissent read from the bench was based on a “misunderstanding” by the conservative justice, the Supreme Court said Friday.
Essentia again ranks among Minnesota's best for quality care
Minnesota Community Measurement (MNCM) — a statewide resource providing timely, comparable information on healthcare quality, costs and equity — once again ranks Essentia Health as a quality leader in its annual Health Care Quality Report.
Trump threatens 100% tax on European imports if countries impose tax on digital services
“Please let this statement serve to represent that any Country that imposes such a Tax will immediately be met with a 100% TARIFF on any and all Goods sent to the United States of America,” Trump wrote in a post on social media.
These Deals on Video Games, Controllers, and Peripherals Will Disappear When Prime Day Ends Tonight
These are the best last-chance gaming deals for the last day of Prime Day: Save on top video games like Elden Ring, plus premium controllers, gaming mice, and essential peripherals.
Strictly Business Cannes Lions: Deloitte, AWS, Sony Execs on AI and Tech Adoption
Variety Strictly Business Podcast Live presented by AWS & Deloitte featured Deloitte's Michelle McGuire, AWS's Ruba Borno, and Sony Pictures Entertainment's Pete Wood.
Strictly Business Cannes Lions: Deloitte, AWS, Sony Execs on AI and Tech Adoption
Variety Strictly Business Podcast Live presented by AWS & Deloitte featured Deloitte's Michelle McGuire, AWS's Ruba Borno, and Sony Pictures Entertainment's Pete Wood.
Volkswagen reportedly planning to axe 100,000 jobs
Volkswagen, one of the world’s largest automakers, is reportedly planning to axe as many as 100,000 jobs over the next few years, representing 15% of its global workforce.
Chairman Guthrie, Health Vice Chair Harshbarger, Congresswoman Miller-Meeks Lead Site Visit to Iowa Hospitals to Highlight Benefits of the Rural Health Transformation Program
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
Sweden and WHO launch new long-term initiative to transform Ukraine’s health system
WHO and the Swedish International Development Cooperation Agency (Sida) have launched a new multi-year cooperation project to support the long-term recovery and transformation of Ukraine’s health system. The new project, “Ukraine’s Health System Transformation Initiative: Strengthening Health Governance, Health Financing and Service Delivery for Long-Term Recovery”, was launched at the Ukraine Recovery Conference 2026 in Gdansk, Poland on 26 June, and will run from June 2026 to 2029. Sweden will contribute approximately US$ 26 million (240 million Swedish krona) to support this project. This contribution forms part of Sweden’s broader support to Ukraine through the Team Europe approach, which brings together the European Union, its Member States, and key partners such as the European Commission’s Directorate-General for Enlargement and Eastern Neighbourhood and Enabel, and WHO as lead health agency, to support Ukraine’s recovery, reform agenda and European integration.“Ukraine’s health recovery cannot be measured only by what is rebuilt, but by whether people can count on the health system when they need it most. The scale of the task is immense, with health reconstruction and modernization needs estimated at US$ 19.4 billion over the next decade. Sweden’s US$ 26 million contribution to Ukraine’s Health System Transformation Initiative is a timely investment in the institutions, financing and services that will support Ukraine’s long-term recovery and European integration. WHO remains a trusted partner of the Government of Ukraine in advancing this process. I am deeply grateful to Sweden for its consistent support and partnership,” said Dr Hans Henri P. Kluge, WHO Regional Director for Europe. More than 4 years of war have placed unprecedented pressure on Ukraine’s health system, creating 3 interconnected challenges. The first is responding to the immediate consequences of the war and the urgent health needs of the population. The second is recovering and modernizing health services today. The third is continuing reforms and aligning the health system with European standards in the context of Ukraine’s future accession to the European Union. The war has led to large-scale population displacement, an increasing need for trauma care and rehabilitation, and shortages of health workers. High out-of-pocket payments in Ukraine make access to health services more difficult. Around 46% of total health expenditure is paid directly by individuals, placing a significant financial burden on many households and underscoring the need for reforms in health financing. Older people, persons with disabilities, women, children and veterans continue to face the greatest difficulties in accessing health services. “Ukraine is demonstrating that health system transformation can continue even during war. Ukraine is also continuing to align its health system with European norms and standards. WHO is committed to supporting Ukraine on this journey. We provide technical support, help coordinate partners’ efforts and support the institutional changes needed to strengthen the system. We are grateful to Sweden for its support. Through this partnership, we can help Ukraine build a more resilient, accessible and people-centred health system,” said Dr Jarno Habicht, WHO Representative in Ukraine. About the Health System Transformation InitiativeThe new initiative will support Ukraine through 3 interconnected areas: strengthening governance and coordination of health sector reforms through more inclusive coordination platforms and structured policy dialogue; transforming service delivery by reinforcing a primary health care-centred model that integrates family medicine, nursing and midwifery; and improving financial sustainability by supporting reforms that ensure the long-term viability of the national health system and reduce out-of-pocket payments for households. Overall, these reforms are expected to make the health system more coherent and easier to navigate, improve the quality and continuity of care, and ensure more equitable access to services, particularly for those who need them most. They will also support Ukraine’s progress towards a more modern health system aligned with European standards. “We are convinced that long-term recovery is not possible without strong, high-quality, person-centred health services that are accessible to everyone. Our partnership with WHO is designed to support deep and lasting systemic changes. Investments in human capital especially autonomous midwives, whose role for maternal, newborn and adolescent sexual and reproductive health cannot be understated, stronger governance, digital transformation and the financial sustainability of the health system are investments in Ukraine’s future. We are proud to support this process,” said Malin Perhult, the Head of the Ukraine Unit at Sida. Focus throughout implementation will be given to the most vulnerable population groups, including older people, women and children, and persons with disabilities, who have been affected by the war and face greater health-care needs. The initiative will be implemented in close cooperation with the Ministry of Health of Ukraine, the National Health Service of Ukraine, the Public Health Centre of Ukraine, regional authorities and international partners. This project will help Ukraine move towards a system where everyone can access the health care they need. It will strengthen primary care, make the health finance system more stable and predictable, and reduce the out-of-pocket costs that Ukrainians face when using health services. As a result, the Ukrainian health system will become more aligned with European standards and more sustainable in the long run.
Outdoor recreation study highlights economic challenges for Wyoming businesses
The report represents the first comprehensive study of the state’s outdoor recreation economy. Businesses ranked hiring, climate and marketing as top concerns.
CORUS ENTERTAINMENT ANNOUNCES FISCAL 2026 THIRD QUARTER RESULTS
CorusEntertainmentInc. (TSX: CJR.B) announced its third quarter financial results today.
SpaceX employees get rich off IPO while Blue Origin workers miss out
Three ex-employees of Jeff Bezos' rocket maker said Blue Origin's approach to equity left them with stock options that are essentially worthless.
Gay Street businesses cope with Capital Line construction
The Capital Line is meant to be transformative for Downtown. But right now it's presenting challenges for businesses.
DJ and presenter Trevor Nelson taking a break from work due to health issues
The Radio 2 presenter said he was now "concentrating on getting better".
MINNEAPOLIMEDIA PRESENTS | This Weekend in the Twin Cities – Entertainment Guide: June 26 ~ June 28, 2026 Edition
Twin Cities weekend features Pride, Breakaway, concerts, festivals, theater, museums and family events across Minneapolis, St. Paul and beyond.
Senate Indian Affairs Committee Advances Mark Cruz’s Nomination to Lead Indian Health Service
U.S. Senator Lisa Murkowski (R-Alaska), Chair of the Senate Committee on Indian Affairs, led a nomination hearing to consider Mr. Mark Cruz, of Oregon, to be Director of the Indian Health Service within the U.S. Department of Health and Human Services and expressed her intent to support his nomination. Representative Tom Cole (R-Okla.), a citizen […]
Healthy Employees Are Good. Healthy Leaders Matter More
Healthy, sharp employees are essential to a strong organization. But sequencing matters. High-performing organizations start with leaders.
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street
Corporate dark money groups are funneling millions into eleven different races statewide.
Trump will present the World Cup trophy. It could be VERY awkward
The president has launched a war with nation in the tournament, and a war of words with many others.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
College Sports Commission to continue reviewing deals by multimedia rights companies
A judge ruled that multimedia rights companies that represent university athletic departments can continue to be subject to the same rules governing millions in third party name-image-likeness payments to players that are reshaping college sports.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Following IAM Union Advocacy, Kansas PERB Orders Count of Timely Cast Ballots in KU Health System Pharmacy Technician Union Election
KANSAS CITY, Kan. — Following weeks of advocacy from the IAM Union, Pharmacy Technicians, elected officials and community supporters, the Kansas Public Employee Relations Board (PERB) has ruled that 37 previously uncounted ballots will be included in the final tally of the recent union representation election involving Pharmacy Technicians at the University of Kansas (KU)
Emily Ratajkowski says she rejects the label 'divorced single mom'
Emily Ratajkowski is opening up about resenting the label "divorced single mom" following her split from ex-husband Sebastian Bear-McClard.
Health Subcommittee Markup of 15 Bills Addressing Illicit Drugs and Health Care Price Transparency
The Committee on Energy and Commerce is the oldest standing legislative committee in the U.S. House of Representatives and is vested with the broadest jurisdiction of any congressional authorizing committee.
MIT in the media: Exploring how curiosity-driven science is an essential ingredient in America’s success
“Scientific American” showcases the history and future of America’s scientific engine, highlighting promising young scientists and icons at MIT and beyond.
Another look at carrots and eyesight; how to get more fiber; why mosquitoes bite some people and not others; plus other stories with Vanderbilt Health sources
AARP reporter Stacey Colino interviewed Milam Brantley, MD, Associate Professor of Ophthalmology and Visual Sciences, in 2020 for a story about whether eating carrots can improve vision. Sacramento Bee reporter Samantha Agate has now used Brantley’s comments in an AI-curated story created by content specialists on the same topic that has been picked up by MSN and others. Prevention magazine interviewed Heidi Silver, RD, PhD, Founding Director of the Vanderbilt Diet, Body Composition, and Human Metabolism Core, for a story about the importance of fiber and how people can get more of it in their diet. William Schaffner, MD, Professor of Preventive Medicine, was quoted by several news outlets about public health issues, including: Women’s Health (tick bites and alpha-gal syndrome); The Washington Post (tetanus); and Healthline (why mosquitoes prefer to bite some people and leave others alone). A visit to Monroe Carell Jr. Children’s Hospital at Vanderbilt by some Banana Ball baseball players was covered by The Tennessean and WZTV Fox 17 News, and The Tennessean’s story was also picked up by Yahoo! Sports. Clarksville Now published a story written by the Montgomery County Economic Development Team, whointerviewed Bradley Stancombe, MD, professor of Clinical Pediatrics, Vanderbilt Neonatology, about the new energy of Vanderbilt Clarksville Hospital and how the facility is recruiting physicians. Healio Allergy/Asthma group editorial director Richard Gawel interviewed Mark Rolfsen, MD, Clinical Fellow in the Division of Allergy, Pulmonary and Critical Care Medicine, for a story about his presentation at the American Thoracic Society meeting on metal health outcomes following ICU discharge. Nashville Scene reporter Hannah Herner interviewed James Crowe, MD, Director of the Vanderbilt Center for Antibody Therapeutics, for a story about his efforts to prepare for the next pandemic by isolating antibodies that can neutralize dangerous viruses. Medscape reporter Kathleen Doheny interviewed Neesha Choma, Associate Chief of Staff of Vanderbilt University Hospital, for a story about how hospitals can reduce readmissions.
Texas Democrats head to convention with optimism, but questions about November remain
The Texas Democratic Convention begins Thursday in Corpus Christi. The three-day convention features several national and statewide figures in the party — this while polls show Democratic candidate James Talarico essentially even with his Republican opponent for U.S. Senate, Attorney General Ken Paxton.
Germany’s Merck to Buy Bio-Techne for $11 Billion
Merck KGaA offered $73 a share in cash to buy Bio-Techne, representing a 24% premium to the U.S. lab-tools supplier’s closing price Wednesday.
Commentary: Why Archie Bunker voters are disillusioned with U.S. politics
The 1970s “All in the Family” stalwart supported law-and-order, cultural conservatism and strong labor unions, values to which many Republicans have gravitated, while Democrats evolved into a constituency that adopted identity…
Susan Collins is testing whether old school politics still work
In the modern era, political activists want their representatives to fall strictly in line. To the base, the independent centrist is no longer a hero; they are a villain to be purged. But Susan Collins has a pitch that she is an independent voice.
In wake of homicide on Tyler Street, nearby business owners reaffirm faith in community
In the aftermath of last week’s homicide on Tyler Street, local business owners in the area told The Eagle that the incident is not representative of the neighborhood’s character.
A lack of funding, a glut of stigma: How Ohio LGBTQ+ health outcomes are impacted
For the 1 in 10 Ohioans who identify as LGBTQ+, media representation and social acceptance may have improved, but stigma and discrimination still impact them in large aspects of their lives, including healthcare access.
CVS Health Foundation invests $1 million in Hartford nonprofits tackling community health needs
Local organizations receive Hometown Fund support to expand access to health care, food, housing and essential services
Sister’s Gift Represents Transplant First at Sutter Health
Photo caption: Dr. Eric Miller adjusts the image focus on the da Vinci 5 robot as he performs Sutter’s first fully robotic living-donor kidney transplant. | June 2, 2026 Sutter’s California Pacific Medical Center (Sutter’s CPMC) in San Francisco has performed its first fully robotic living-donor kidney transplant, marking a significant milestone for the system’s […]
WATCH: Under proposed rule, USPS won't deliver mail ballots to states that don't provide voter rolls, postmaster general says
Postmaster General David Steiner told a Senate committee Wednesday that, if a proposed rule is adopted, the U.S. Postal Service would withhold mail ballots from states that do not hand over to the federal government lists of people who have requested absentee or mail ballots.
'ANTM' cycle 25 might cast 'an AI contestant,' Tyra Banks rep says (exclusive)
'America's Next Top Model' cycle 25 might include 'an AI contestant,' a representative for Tyra Banks exclusively tells EW after Banks' ice cream brand removed AI-generated models from an ad.
How Brexit broke British politics
Brexit has had a lasting impact on British politics, causing a decade of turmoil and division, and resulting in the resignation of Prime Minister Keir Starmer after two years of economic stagnation and a divided electorate.
5 takeaways from New York 2026 primary election results
New York primary voters on Tuesday sent a lot of messages to elected officials.
Dunnellon to mark America 250 with fireworks, entertainment
This year’s Fourth of July carries extra meaning for many citizens, as it represents the 250th anniversary of the signing of the Declaration of Independence. For the first time in
Perks of the job: Save on entertainment and essentials with BenefitHub
State of Colorado employees have access to a wide-ranging corporate discount marketplace, and those eligible for benefits at Metropolitan State University of Denver can take advantage of them with their University email. The State of Colorado BenefitHub offers deals on thousands of products, ranging from vacation and event tickets to insurance and other essential services. […]
Hong Kong Digital Entertainment Association Presents the 3rd "Future Animation - AI-Assisted Animation Production Support Scheme"
/PRNewswire/ -- Organised by the Hong Kong Digital Entertainment Association (HKDEA) and sponsored by the Cultural and Creative Industries Development Agency...
Otto the Orange Levels Up at EA Sports’ Opening Drive
Otto traveled to Chicago to represent the ACC in EA Sports' College Football 27, with the Center for the Creator Economy capturing it all.
Scientists finally explain what your dog's eyes do to your brain - Futura-Sciences
That soft look your dog gives you across the room feels like love, and it turns out that is not just sentimental projection. When you and your dog lock eyes, both of your brains release the same bonding hormone that ties a mother to her newborn. Scientists have measured it,...
House gives final approval to landmark housing bill aimed at lowering costs
The legislation represents one of the most sweeping efforts in decades to increase the supply of housing and bring down prices.
Is Giannis Antetokounmpo the greatest Wisconsin sports athlete ever?
The legacy Giannis Antetokounmpo leaves is difficult to even measure. Is he the greatest Wisconsin sports athlete ... ever?
Death Row Disability Cases Are Questions of Morality, Not Science
Doctors’ input on how to weigh cognitive disability in death penalty cases can be helpful, but characterizing such judgments as science misrepresents medicine and psychology, says Dr. M. Gregg Bloche of Georgetown Law.
German Ifo business sentiment rises in June
German business morale rose in June, a survey showed on Wednesday, as companies assessed their current situation more positively and expectations were also somewhat less sceptical.
Cinballera Entertainment to Present 'Il Tabarro'
Cinballera Entertainment will present Puccini's "Il Tabarro' on July 19 at the California Center for the Arts Escondido in Escondido, California.
Automakers could halt car sales in California without delay in vehicle tracking law
A group representing major automakers warned on Tuesday that car companies may be forced to halt sales of both new and used vehicles in California on July 1 unless the state delays vehicle technology rules that aim to prevent perpetrators of domestic violence from tracking survivors.
Khris Middleton to the Heat, too? The speculation has started
On the Hoop Collective podcast, NBA insider Brian Windhorst said he's heard that Khris Middleton to the Heat might be a possibility.
DeepMind Chief Demis Hassabis says Google’s still winning AI talent
Despite the departure of two top AI leaders that sent the company’s stock price down, Hassabis says Google is still on top.
Film Independent Spirit Awards to Present Robert Redford Environmental Vision Award
The new award in the late actor's honor "celebrates environmental fiction film and television projects taking an entertainment-first approach"
Chicago Bears open applications for 2026 Small Business All-Pros presented by PNC
The Chicago Bears on Tuesday announced the return of Small Business All-Pros presented by PNC, a signature community initiative that recognizes local entrepreneurs whose businesses help drive economic growth, create opportunity and strengthen neighborhood
HRSA Announces Maternal Health Grant Opportunity
The grant will support produce prescription programs that aim to improve nutrition access and health outcomes for pregnant and postpartum patients and their families.
The Art of the Dodge: Steven Raga Perfects the Politics of "Progressive Except for Palestine"
The Queens assemblymember built a career on AIPAC support and silence on Gaza. Now, facing a Palestinian American DSA challenger, he’s perfected the political choreography of looking left while leaning right.
The Extraordinary Embezzlement Case That Rocked Scottish Politics
Peter Murrell, the husband of the former Scottish leader Nicola Sturgeon, was sentenced on Tuesday after he admitted to buying a bizarre range of items with the Scottish National Party’s money.
Accounts in Transit: M+C Saatchi Sport & Entertainment Lands HUGO BOSS
M+C Saatchi Sport & Entertainment is named global PR agency of record for HUGO BOSS’s brands BOSS and HUGO.... Zapwater Communications expands its relationship with Banyan Group, strengthening its role as the brand’s agency of record in North America while adding PR representation for overseas....Diffusion comes on board as PR agency of record for Pehr, a baby and kid brand spanning apparel, nursery and gear.
Beatty, Roland Martin talk politics, Black representation, and voting
Congresswoman Joyce Beatty and Roland Martin discuss the future of Black political participation at a Columbus event.
Who are the new 'Love Island USA' bombshells? 6 stars dumped in major Casa Amor twist.
This year's Casa Amor challenge brought a record number of bombshells to the villa — and a dramatic elimination that sent six hopefuls home.
Opinion | What high schoolers get about politics that adults don’t
In high school debate, we can disagree about an issue without devolving into caricatures and misrepresentations of the other side, Eagan High School's debate captain writes.