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Christian Gonzalez Reacts to Record-Breaking Extension with Patriots

Christian Gonzalez got what he wanted and now focuses on bringing the Patriots back to the Super Bowl.

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Sep 16 • 2:57 PM EDT • Sports • sports.yahoo.com
Christmas at the Kringles Horror Comedy Movie Trailer Turns the Holidays Into a Bloodbath

The Christmas at the Kringles trailer is perfect for those seeking a horror comedy with a pure bloodbath. The upcoming film is directed by Kevin Lewis, who previously directed Willy’s Wonderland and P...

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Sep 16 • 1:48 PM EDT • Entertainment • yahoo.com
Palm Beach business PAC backs Christina Romelus in School Board runoff

‘Her experience in education, public service, and the private sector gives her a valuable perspective.’

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Sep 16 • 11:17 AM EDT • Business • floridapolitics.com
Christian County Health Department Offers Personalized Emergency Plans

September is Emergency Preparedness Month, and the Christian County Health Department (CCHD) is helping residents prepare before severe weather or another emergency occurs. CCHD Emergency Preparedness Coordinator, Ellen, is offering to create personalized emergency plans for area households. Residents can call the health department at […]

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Sep 16 • 10:19 AM EDT • Health • taylorvilledailynews.com
Cowboys' Rashan Gary Defends Christian Parker Amid Giants Nightmare
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Sep 16 • 10:06 AM EDT • Sports • sports.yahoo.com
‘Spoilers’ happen in Oregon. Will this year’s race for governor join the list?

Pacific Green candidate Brett Smith could siphon key votes from Gov. Tina Kotek in a tight Oregon governor rematch against Republican Christine Drazan.

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Sep 16 • 9:57 AM EDT • Politics • klcc.org
Liverpool linked with move for former Bayern youngster

A year ago, Bayern Munich agreed to sell Paul Wanner to PSV for a reported €15 million while including a buy-back clause in the deal.According to Bild’s head of football, Christian Falk, Liverpool...

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Sep 16 • 5:39 AM EDT • Sports • sports.yahoo.com
The entwinement of religion and politics in modern life

Michael Wear, CEO of the Center for Christianity and Public Life, explained that religion and politics are essential and coexisting aspects of modern life on Monday. “What is essential to understand is that both the religious, the spiritual and political are essential aspects of life as it is today,” Wear said at the Memorial Union....

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Sep 16 • 5:21 AM EDT • Politics • iowastatedaily.com
New poll shows Christine Drazan with narrow lead in Oregon governor’s race

It’s just the second poll to emerge in the rematch between Drazan, a Republican, and Democratic Gov. Tina Kotek.

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Sep 15 • 7:55 PM EDT • Politics • opb.org
Drazan, Kotek react to election forecast moving further in Republicans' direction

REACTING TO NEW OREGON ELECTION FORECAST: Christine Drazan says Oregonians are "overdue for a change" — while Tina Kotek's campaign says she's the one protecting the state from Trump's agenda.

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Sep 15 • 7:44 PM EDT • Politics • centraloregondaily.com
‘Live Laugh Love’ Untangles the Politics of White Christian Women

In a new book, ‘Jesus and John Wayne’ author Kristin Kobes Du Mez looks behind the shiplap.

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Sep 15 • 4:22 PM EDT • Politics • sojo.net
Business Traveller: Six Months in, the EU’s Entry/Exit System Isn’t Working

Partner Christine Sullivan discusses the implementation of the EU’s Entry/Exit System (EES) across member states and at border crossing points.

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Sep 15 • 2:21 PM EDT • Business • fragomen.com
Hollywood Prayer Network celebrates 25 years of praying for entertainment professionals

Founder Karen Covell says Christian community gathers together to encourage each other to use God-given talents in a difficult industry.

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Sep 15 • 1:03 PM EDT • Entertainment • foxnews.com
Judge blocks Kennedy Center board from putting Trump’s name on the building or grounds in any way

WASHINGTON (AP) — A federal judge blocked the Kennedy Center on Tuesday from returning President Donald Trump ’s name to the iconic performing arts venue in a move meant to recognize his renovation efforts, saying it would violate an earlier ruling that his name was illegally added to the building. Judge Christopher Cooper ruled that, […]

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Sep 15 • 12:47 PM EDT • Politics • coloradopolitics.com
Deep dive
😐 Neutral (-1%)
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OKC Thunder Sign Christoph Tilly for Training Camp

The Oklahoma City Thunder signed Christoph Tilly to an Exhibit 10 deal, and his playstyle and skill set could greatly benefit his fellow rookies as they develop together with the Blue.

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Sep 15 • 12:00 PM EDT • Sports • sports.yahoo.com
The sinister influence of crypto billionaires on our politics

Letters: Readers respond to the news that Christopher Harborne has given £36m to Reform UK, matching a donation from Ben Delo

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Sep 15 • 11:52 AM EDT • Politics • theguardian.com
Lawndale Christian Health Center’s New Facility Specializes In Family And Senior Care

The Ogden Avenue center will serve 11,000 patients annually and will house Lawndale Christian's family medicine and doctor residency programs.

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Sep 15 • 9:37 AM EDT • Health • blockclubchicago.org
Ana Valdez Is Making Business Leaders Recognize Latino Economic Power

The president and CEO of the Latino Donor Collective is transforming how companies serve their customers

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Sep 15 • 9:01 AM EDT • Business • time.com
Business Beat : Siberian Solstice bringing rocking Christmas show back to The Historic Tibbits Opera House

COLDWATER, MI (WTVB) - The acclaimed holiday touring group Siberian Solstice will return to Coldwater's histor...

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Sep 15 • 8:17 AM EDT • Business • wtvbam.com
Southern Delaware hospitals oppose ChristianaCare’s proposed campuses, arguing they don’t meet state requirements

If approved, the two “neighborhood hospitals” proposed for Camden and Georgetown would open in 2028. Other hospital systems question if they actually comply with state law.

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Sep 15 • 5:00 AM EDT • Health • whyy.org
Writer argues Bible anticipated modern science, from hygiene...

An evangelist argues that biblical passages on washing, quarantine and the heavens anticipated later scientific discoveries and point to Christian faith.

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Sep 15 • 12:39 AM EDT • Science • waynecojournalbanner.com
Will Netflix’s Latest Horror Film Save Its Summer? And Introducing a New Data Source...

(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) All month, I’ve been polling you, my readers, on how we think the summer’s biggest blockbusters will do when they eventually land on streaming, and I wanted to share the results. First up, how readers think The Odyssey will perform when it comes to Peacock... People are pretty bullish that The Odyssey will smash it for Peacock. I don’t know that it will have as much rewatchability as Wicked did for kids, but we’ll see. It is now Universal’s highest-grossing film of all time. One note: almost half of Christopher Nolan’s films weren’t available for streaming the week The Odyssey came to theaters, including some of his biggest films like Inception, Dunkirk, Tenet, Oppenheimer and Insomnia. If you did want to watch the others, Prime Video had Memento and The Dark Knight trilogy, HBO Max only had The Dark Knight trilogy (even though Warner Bros. produced most of Nolan’s films), Hulu had The Prestige and Interstellar, and Paramount+ had Interstellar. So you needed at least two streaming subscriptions to catch the rest. Warner Bros. whiffed right here. I know they have long term licensing deals, but they should have tried to get as many Nolan films on HBO Max for launch as possible. Here are the results for Spider-Man: Brand New Day: The audience is a bit more mixed on this one, with everyone agreeing Spider-Man will swing to a big opening, but not necessarily elite or best all time. On to this week’s issue. Netflix continues searching for a hit straight-to-streaming summer film and Lioness and Ted Lasso allow me to look at the difference between a “hit” and a ‘hit for them”. All that, plus new YA/teen melodramas on Prime Video and Netflix, the House of the Dragon finale, USA Network claims a big opening, more big NFL ratings, all the flops, bombs and misses, and a whole lot more. But we start with a fun new data announcement. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of August 3rd to August 9th, 2026. You can find a link to my terminology here.) Subscribe A New Data Source: Reelgood’s Data on Content Libraries Here’s a fun new treat for you. Reelgood—an online service and app that lets users track where shows or films are streaming—is providing data every month for the Streaming Ratings Report on the size of each streamer’s catalogue, along with the new shows and films for each streamer. Yay! Previously, I had pulled “new shows on streamers premiering on the first of the month”: While I liked that data cut, it was a big wonky since it didn’t show all of the new shows or movies that came to a streamer each month. Instead, I would have preferred something like this from Reelgood’s annual report: And now we have it! I’m going to feature Reelgood’s data monthly, showing both total catalogue size and new shows and films appearing on the charts. That’s going to make these two cool new charts. First, here’s the size of various streamers’ film catalogues… (By the way, Reelgood offered to make the charts for me, but I like doing that task by hand to understand the data better.) They also provided data back to last year. Here’s the number of films timeline: And here are the new films on each streamer for the month prior to Aug: As I get used to this data, I plan to keep tinkering with how I display it, but I’m excited to feature it monthly. Today, I’m sharing the film charts; next issue, I’m going to feature TV shows by streamer. Now, in full disclosure, Reelgood is a sponsor of this little-newsletter-that-could. But in my constant quest to figure out what streamer various shows and films are on, I was already a Reelgood user before this sponsorship. I go to their website all the time, and their data is very accurate on where shows are (or have been). Plus, I’ve been sharing their weekly top ten lists for years now, pre-sponsorship. For me, this is a great win-win, since I get to amplify a service I love, and I get a cool new data source to play with. Now, normally folks don’t usually mention their sponsors directly, but as I wrote before, as I start featuring ads in my newsletter, I plan to be extremely open about who is sponsoring my writing so you can trust what I write. Television - Two Big Returning Shows Look Set to Take Over The Charts One key question when it comes to judging streaming shows is whether a show is a “hit” or a “hit for them”. To be clear, the former means a show that’s one of the top shows on streaming, no questions asked. The latter means a show is one of the biggest, for a given streamer. That distinction makes a big difference! It’s really good to be one of the biggest shows on a streamer; it’s much better to be the biggest on streaming, despite the size of a streamer. Because, as we’ve seen now, nearly every streamer—while lacking the number of subscribers or usage of Netflix—can make hit TV shows: Paramount released Landman, whose first and second seasons were among the top two TV shows the year they came out. HBO Max’s The Pitt’s second season is the biggest show of the year so far. Love Island USA was the top show in 2025 for Peacock. And, crucially for today’s discussion: Wayyyyyyyyyyyyyyyyyyyyyyyyyy back in 2023, Ted Lasso was actually the top streaming show of the year according to Nielsen! So even Apple TV (formerly +) can make hit shows. It just doesn’t make them that often. And looking at the Nielsen charts this week, we have two prime candidates for this discussion: That’s right: Ted Lasso returned to Apple TV for its fourth season. Did it return in all its expected glory? Sure, though right now it’s still just a “hit for Apple TV”, but we’ll see how long it lasts on the charts. Its ten episodes are coming out weekly. (Smart choice, Apple!) Ted Lasso started out strong, actually making the Nielsen charts the week before new episodes dropped, which is a rare feat. (Shows like Stranger Things or Bridgerton have pulled that off. That’s terrific company to join!) On Nielsen, it opened to 14.4 million hours in its first week, and 16.6 million the week of 10-Aug. Here’s how that compares to previous seasons: Apple put out that this is their biggest TV launch through two days ever, and looking at the chart and Apple TV’s viewership history, I’d believe it. Here’s Apple’s top shows for season two and beyond: Other data tells a (mostly) similar story. Ted Lasso made Samba TV and it has elite IMDb scores, an insane 8.7 on 465K reviews. The only outlier is Luminate, where the latest season only had 7.4 million hours, and no other seasons made the top ten. As you’ll see below, that’s well below some other solid, but not spectacular shows like Sterling Point, Ride or Die or Furious. I’d be surprised if Ted Lasso isn’t bigger than those other shows, but it’s fine for different data sources to occasionally disagree. And while it’s sucky to bring this up, given that Warner Bros. produced this show, I do wonder how the streaming wars may have been different if Ted Lasso landed on HBO Max initially instead of Apple. I don’t think one show can make or break a streamer, but given HBO’s brand, it could have helped bring people to that streamer much earlier in its lifespan. (Though yeah, I don’t love calling out executives for passing on hit shows, since that’s just the nature of the job. Even the absolute best execs will pass on lots of successful shows. The key is not greenlighting the under-performers/misses.) The other show I’m thinking about in the “hit or hit for them” category is Lioness from Paramount+. Like Ted Lasso, its first season missed the charts, but it’s grown its audience since then. Here’s how season three opened: We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How Lioness did on streaming... Two new melodramas for Netflix and Prime Video... Whether Netflix’s latest horror film saved its summer... Hulu’s Furious and Prime Video’s Ride or Die continuing their strong runs... The latest high profile showrunner to flop on streaming... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. Next week, we’ve got a double issue—since the week of 17-Aug had very few notable new shows or films—so I’ll look at HBO’s Lanterns, Prime Video’s Reacher, Netflix’s Tires, Outer Banks (which posted up huge numbers four years ago), an Aussie romance, and another baseball event (that didn’t resonate). And a bunch of movies like the latest dramedy from an Adam Sandler daughter, Don’t Say Good Luck, Camp Rock 3 on Disney Channel and Disney+, Michael on Starz, and more. Later this month, we’ve got a ton of shows and films to analyze! Movies will be the big story, featuring a box office bomb (Supergirl on HBO Max) and an “underperformer” (The Mandalorian and Grogu on Disney+) contending with a bunch of star-studded straight-to-streaming films like Netflix’s The Whisper Man (Adam Scott, Michelle Monaghan and De Niro!), Mayday on Apple TV+ (Ryan Reynolds and Kenneth Branagh!), The Runner (Gal Gadot) and The Last Sunrise (Eva Longoria and Maia Reficco) on Prime Video. Plus, a ton of TV shows have sophomore seasons coming out. Will The Gentleman put up big numbers on Netflix or suffer from a sophomore slump? Leanne and Beauty in Black on Netflix seem small, but they both might be bigger than you think. Hulu has a bunch of shows: a new season of The Secret Lives of Mormon Wives (the first after all the controversy last year) and the second season of Chad Powers (from Peyton Manning’s production company and starring Glen Powell). This one flopped last year; can it score a touchdown this year? Same goes for FX’s Adults, which I didn’t track last year; will it hit this year? Peacock’s The Office spinoff, The Paper and Apple TV’s Dark Matter also return for second seasons. And Netflix has more Untold specials featuring Vince Young, Raygun (that horrible breakdancer) and Mr. T. Long term, Paramount+ is rebooting yet another franchise, Clueless, and I’m somewhat bullish on this new show. The talent attached (Alicia Silverstone) and creative Josh Schwartz and Stephanie Savage (of The O.C. and Gossip Girl) also feel solid...if they make it funny like the original.

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Sep 14 • 6:43 PM EDT • Entertainment • entertainment.substack.com
High Flying ‘Train’ a Crowd Favorite

On Saturday, at the Orleans County Fair, fans were treated to three motocross performances featuring local, Christian Poutree (seen far right). The highlight of the event was The Train, with

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Sep 14 • 4:16 PM EDT • Entertainment • newportvermontdailyexpress.com
Lucas County prosecutors to review Mercy Health officer shooting case

Authorities said Christian Strassburg got into an altercation involving an officer, and that officer shot and killed him.

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Sep 14 • 4:14 PM EDT • Health • 13abc.com
Detroit Lions Release Initial Week 2 Injury Report

The Lions released their first Week 2 injury report, with Christian Mahogany, Blake Miller and Juice Scruggs all dealing with injuries.

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Sep 14 • 4:11 PM EDT • Sports • sports.yahoo.com
One Detroit Lions Starter May Have Just Lost His Job

Ben Bartch impressed after Christian Mahogany’s Week 1 injury, potentially reopening the Detroit Lions’ competition at starting left guard.

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Sep 14 • 3:10 PM EDT • Sports • sports.yahoo.com
First AI Sciences Major at Idaho State Blazes His Own Trail

First AI Sciences Major at Idaho State Blazes His Own Trail

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Sep 14 • 1:48 PM EDT • Science • isu.edu
Richard Tice rallies to the defence of Reform’s crypto ‘patriots’

You can’t buy Dicky’s level of stupidity though it could be argued that Christopher Harborne and Ben Delo just have

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Sep 14 • 1:05 PM EDT • Politics • theguardian.com
Packers Film Room: Christian Watson doubles-up

Taking a look at Christian Watson’s two touchdown day against the Vikings

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Sep 14 • 11:52 AM EDT • Sports • sports.yahoo.com
“Sister Wives” stars Kody Brown and Robyn Brown exit reality series after 16 years

His former wives Christine Brown Woolley, Meri Brown, and Janelle Brown will return for season 21.

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Sep 14 • 9:28 AM EDT • Entertainment • yahoo.com
How legal aid helps Children’s Minnesota patients beyond the hospital

Christina Toro faced the possibility of losing her housing while caring for her infant grandson. Free legal help from Children’s Minnesota gave the family more stability.

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Sep 14 • 7:00 AM EDT • Health • sahanjournal.com
RB Leipzig Finally Find Their Spark as Hamburg Collapse

Antonio Nusa’s masterclass and Christopher Nkunku’s return fueled a five-goal demolition of HSV, silencing critics and reviving Martin Demichelis’s side despite a looming injury blow.

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Sep 14 • 6:40 AM EDT • Sports • sports.yahoo.com
Pulisic at Milan: Is the best still to come?

Christian Pulisic’s time at Milan has strengthened the argument that his most productive years may still be ahead of him. After the expectations and competition that followed him through earlier sta...

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Sep 14 • 6:05 AM EDT • Sports • sports.yahoo.com
Is Inde Navarrette from Corpus Christi?

"I grew up in Texas for a good majority of my life," Inde Navarrette said.

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Sep 14 • 2:02 AM EDT • Entertainment • mysanantonio.com
Updated New Orleans Pelicans Roster After Signing Christian Shumate

How the New Orleans Pelicans roster will look heading into training camp after the Christian Shumate pickup.

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Sep 14 • 1:01 AM EDT • Sports • sports.yahoo.com
Christian Parker failed his entry exam with the Dallas Cowboys

Christian Parker’s debut was a failure

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Sep 14 • 12:00 AM EDT • Sports • sports.yahoo.com
Christian Watson's family, ex-Packers sound off on 'unacceptable' finish

Former Packers stars David Bakhtiari, Nick Collins, LeRoy Butler and more sound off on the Week 1 collapse to the Vikings. What they're saying.

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Sep 13 • 10:53 PM EDT • Sports • sports.yahoo.com
😐 Neutral (20%)
“Grease 2”’s Christopher McDonald on the film’s surprise celebrity fans — and the role he almost played instead

The “Hacks” star reacts to “Stranger Things” actress Millie Bobby Brown’s obsession with his cult classic, and shares the larger part he almost played in the film.

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Sep 13 • 9:30 PM EDT • Entertainment • yahoo.com
Dan Campbell Delivers Christian Mahogany Injury Update

Dan Campbell delivered encouraging initial news on Christian Mahogany after the Lions guard left Sunday's win over the Saints with an injury.

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Sep 13 • 8:38 PM EDT • Sports • sports.yahoo.com
'Back in Black' review: Christopher Walken is hilarious as a quirky undertaker

Ella Ballentine goes from "Anne of Green Gables" to "The Vampire Lestat," to a killer comedy.

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Sep 13 • 7:15 PM EDT • Entertainment • mashable.com
“The Summer I Turned Pretty” star Christopher Briney finally reveals how he broke his hand

The actor stars alongside Chase Infiniti, Jason Isaacs, and Gillian Anderson in “The Julia Set.”

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Sep 13 • 2:47 PM EDT • Entertainment • yahoo.com
Christian Mahogany injury update: Detroit Lions LG carted of (knee)

Detroit Lions starting left guard Christian Mahogany suffered a knee injury in the season opener vs. the Saints.

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Sep 13 • 1:42 PM EDT • Sports • sports.yahoo.com
Lions LG Christian Mahogany Suffers Injury vs. Saints

Lions starting left guard Christian Mahogany left Sunday’s Week 1 game after going down during a Jahmyr Gibbs run. Ben Bartch replaced him.

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Sep 13 • 1:31 PM EDT • Sports • sports.yahoo.com
☹️ Negative (-30%)
Family of late Iowa State sports editor fundraises for scholarship, studio renovation

Christian was killed in a wrong-way car accident on Highway 30. He was just 26 years old.

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Sep 13 • 9:47 AM EDT • Sports • kcrg.com
😐 Neutral (16%)
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Detroit Lions Have One Final Injury Decision Before Kickoff

Christian Izien is Detroit’s only questionable player for Week 1 as the Lions make one final injury decision before facing the Saints.

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Sep 13 • 9:31 AM EDT • Sports • sports.yahoo.com
😐 Neutral (0%)
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What if Rutgers pulls the plug on Schiano? Who’s next?

I know, still ten more games. But, it’s when, not if. Time to start thinking who could we get to replace him? I know more than a few people who start shopping for Christmas in July….well, actually they never stop shopping. They have a notebook (okay, a notes app on their phone) where they list […]

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Sep 13 • 8:55 AM EDT • Sports • sports.yahoo.com
Arsenal analysis: Raya proves worth with crucial contribution

Arsenal's first-half frustration was encapsulated in manager Mikel Arteta being booked shortly before the break for leaving his technical area too many times. Greece winger Christos Tzolis continued his inconsistent start to the season, more reminiscent here of his toothless showing against Aston Villa rather than the productive display at home to Chelsea. Konsa, even before giving away the penalty, struggled to deal with Sunderland's direct attacking approach and the physicality of striker Brian Brobbey.

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Sep 13 • 6:27 AM EDT • Sports • sports.yahoo.com
😐 Neutral (20%)
Mullins delighted for Doidge after first County goal

Newport County boss Hayden Mullins was pleased for Christian Doidge after the striker scored his first Exiles goal in Saturday's 1-1 draw with Fleetwood. Doidge, one of many summer signings at Rodney Parade, opened his Newport account with a close-range finish, capping off a fine team move. The 34-year-old's goal followed a big miss in the first half, when he failed to sort his feet quickly enough to convert Harrison Biggins' cross.

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Sep 13 • 2:29 AM EDT • Sports • sports.yahoo.com
Tucker Kraft's teammates, wife congratulate tight end on contract extension

From David Bakhtiari to Christian Watson to Marcedes Lewis, see how they're reacting to Tucker Kraft's contract extension with the Packers.

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Sep 12 • 8:58 PM EDT • Sports • sports.yahoo.com
NASCAR Cup Series Starting Lineup: Enjoy Illinois 300 At Gateway

The NASCAR Cup Series starting lineup for the Enjoy Illinois 300 at World Wide Technology Raceway Gateway is officially set. Joey Logano will lead the field to the green flag after setting the fastest time in qualifying. Kyle Larson will start alongside Logano on the front row, while Ryan Blaney and Christopher Bell will start […] The post NASCAR Cup Series Starting Lineup: Enjoy Illinois 300 At Gateway appeared first on Stadium Rant.

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Sep 12 • 5:35 PM EDT • Sports • sports.yahoo.com
😐 Neutral (20%)
Crypto billionaires donate millions to Reform UK, raising concerns about money in politics

Reform UK, the anti-immigration party led by Nigel Farage, received £72 million (around €83.9 million) from two cryptocurrency billionaires this weekend, prompting concerns about money’s influence in British politics. Ben Delo, co-founder of the BitMEX platform, donated £36 million, and crypto investor Christopher Harborne matched that amount. Harborne supports Reform UK’s policies, believing they will […]

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Sep 12 • 3:32 PM EDT • Politics • europeaninterest.eu
GB's Skupski wins US Open doubles title with Harrison

Britain's Neal Skupski and American partner Christian Harrison win the US Open men's doubles to secure their second Grand Slam title together.

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Sep 12 • 2:59 PM EDT • Sports • sports.yahoo.com
What Can Texas Tech Expect on Offense Against Oregon State?

Texas Tech got the job done in its opener with a 33-10 win over Abilene Christian, but the defense seemed to do most of the dirty work for the Red Raiders. How will Will Hammond and company respond against Oregon State?

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Sep 12 • 1:00 PM EDT • Sports • sports.yahoo.com
Christian County Health Department Talks Vaccine Recommendations

The Christian County Health Department is encouraging community members to be vaccinated against respiratory illnesses. They highlight the flu, COVID-19, and RSV as the key conditions to be aware of, with vaccine recommendations differing by a number of factors. The health department offers the vaccines […]

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Sep 12 • 11:30 AM EDT • Health • taylorvilledailynews.com
Germany’s Political Tailspin: Your Weekly SPIEGEL Recap

It might be tempting to dismiss the results of last Sunday’s state election in Saxony-Anhalt, in which the far-right Alternative for Germany (AfD) party raked in 43.8 percent of the vote, as a rather unimportant extremist blip in a state that hardly anyone can find on the map. And you wouldn’t necessarily be wrong to do so. The state’s population – around 2.1 million – is a mere 2.5 percent of the German total. And while the state capital of Magdeburg was once the political heart of the Holy Roman Empire back when Otto the Great used to hang out there (more than a millenium … no … milennium … nope … millennium ago), it is today something of a backwater, albeit one with a ginormous cathedral in its center. We wanted to briefly interrupt this week’s newsletter to extend a heartfelt thank you to all of our subscribers, both new and old. And to remind you all that a free subscription gets you access to this newsletter every Saturday. A paid subscription, by contrast, gets you one DER SPIEGEL article every weekday, delivered to your inbox. We strive to select pieces that both demonstrate what Europe’s leading newsmagazine has to offer and provide an international audience – namely, you – with an insight into how Germany and Europe view the world. If you haven’t already signed up for a paid subscription, please consider doing so if you can. Our Substack channel relies entirely on reader support and we are excited to continue offering you the best of DER SPIEGEL. Subscribe But even beyond the fact that a huge percentage of the voters in the state decided to place an X next to a party with an ideological lineage that runs rather directly back to the right-wing extremist soup out of which the Nazi Party was born, the results are a perfect example of a phenomenon that has been plaguing German elections in recent years: the lack of an obvious path to a majority. Call it the Balkanization of German politics. There are a number of developments driving the phenomenon, but for the purposes of this newsletter, here are two of the most salient: Persistent voter frustration with the country’s two (former) big-tent parties – the Christian Democrats (CDU) on the center-right (17.2 percent in Saxony-Anhalt last Sunday) and the Social Democrats (SPD) on the center-left (9.3 percent). The presence of parties on the far left (Left Party), the populist left (the Sahra Wagenknecht Alliance – BSW) and the far right (AfD) with which mainstream parties are reluctant to form coalitions. So what happens now? Stories of the Week A Lack of Leadership The answer for many people in the country, and particularly within the CDU, is clear: pin (some of) the blame on Chancellor Friedrich Merz. According to a survey taken directly after the election in Saxony-Anhalt, 88 percent of respondents agreed with the statement that if the federal government in Berlin were doing a better job, the AfD wouldn’t be as strong. And it is true that the predominant impression of the federal government ever since Merz was sworn in on May 6, 2025, is one of ineffectiveness and bickering. His rather unique combination of bumbling-plus-bravado has also not exactly endeared him to the German public. Indeed, his standing in the country is so shaky that his popularity – according to recent polls – has now dropped even below the historic lows associated with his predecessor Olaf Scholz. The situation is such that the CDU even opted to keep him largely out of the campaign ahead of the Saxony-Anhalt vote. And since then, dissatisfied rumblings within the CDU have grown louder. DER SPIEGEL’s Swantje Karich notes that the problems with the CDU go much deeper than Merz. “The center-right has a trust problem. At a press appearance following the devastating election result in Saxony-Anhalt, Friedrich Merz said that the party wanted to ‘reach people more effectively’ through ‘emotional engagement.’ It sounded as though he were announcing a political program. On the basis of that statement, it is difficult to take his empathy seriously.” “The Chancellor’s chastened appearance did, at least, reveal where he stands: with his back to the wall. Elections will be held in Mecklenburg-Western Pomerania next week, and the CDU could fare even worse there. The party is polling at between 8 and 10 percent in the state.” “What is at stake is the political tradition that has lent stability to the Federal Republic since 1945: a democratic conservatism that understands what must be preserved, but also how to embrace progress and openness to the world. If the Union continues along its current path, it risks becoming politically irrelevant after the 2029 federal election – and Germany could soon find itself with a government of the far right.” The Trumpification of Political Debate? It is often said in Germany that to understand the political and social trends that will soon be dominant in Europe, one need only look across the Atlantic to the United States. When it comes to political debate, that has certainly proven true. Donald Trump understood early on that triggering mouth-foaming outrage among Democrats is an ideal way to both generate headlines and to secure loyalty among supporters. And he realized that far more quickly than the left side of the political spectrum understood that simply ignoring the old man might be the best recipe. To be sure, there have been signs recently that the US president may be over-relying on the strategy. Earlier this week, in an apparent grandpa-discovers-AI moment, Trump sent out 60 posts in the space of 10 hours, many of them AI-assisted images portraying him as a hero – or showing Iceland as part of the US (outrageous!!!). It was also during that slew of schlock that he explicitly backed the AfD with an “MGGA” post. In Germany, though, the outrage cycle remains in full swing, with much of the focus on those who would dare to vote for the AfD. They are alternately portrayed as being dim-witted, ungrateful, backward, racist or all of the above. That, argues DER SPIEGEL columnist Sabine Rennefanz, is not particularly helpful. “Everywhere on election night, people spoke of a watershed moment, a rupture, a turning point. But what is that supposed to mean in concrete terms? A watershed would imply an interruption, a moment of pause – perhaps even a willingness to rethink and learn. At first, there was little sign of that in the main television panels. Instead, the familiar rituals that had already shaped the election campaign continued: outrage, lecturing and abuse.” “That’s just the tone, one might object. They’re only talk shows. Given that the party’s state branch has been classified by domestic intelligence officials as confirmed right-wing extremist, there are more important problems than hurt feelings on television. Yet although the condescending tone is not the cause of the AfD’s success, it is an expression of the broader mood within the so-called political center – a kind of institutional blindness that too often treats material concerns as a communications problem.” “People have a pretty good sense of whether you like them – whether you approach them with curiosity or merely study, lecture and manage them as a problem group. They notice whether you genuinely want to understand their fears and pain, or whether you are simply waiting for the chance to correct them. They can also tell whether someone still has the energy to change things, or whether they have barricaded themselves behind platitudes and empty phrases.” “Anyone who wants an egalitarian democratic society cannot promise equality only to those whose language, tastes and moral convictions they share. They must also acknowledge the wounds, resentments and fears of those whose political conclusions they consider wrong. Acknowledging them does not mean agreeing with them. But a democracy that communicates with almost half its citizens only through warnings and labels gives up on political debate before it has even begun. An atmosphere must be created in which people can express their opinions without fearing that they will be canceled. We are currently a long way from that.” East-West? One of the clear undercurrents in the election last Sunday was, of course, Germany’s ongoing east-west divide, particularly as it pertains to the success of the AfD. Historically, the party has been far stronger in the former East German states than in former West German states. The fact that this generalization no longer reliably holds is certainly one of the primary concerns that many have about the party’s growth. And yet, there is still a distinct flavor of “stupid easterners, they don’t understand democracy” to the coverage. In the weeks before the vote, there was even a rather interesting back-and-forth in Germany’s culture pages about how ungrateful eastern Germans allegedly are for being pulled out of their pre-reunification backwardness and into the light of the West. DER SPIEGEL’s Jochen-Martin Gutsch has had enough. “Ten years ago, in 2016, elections were also held in Saxony-Anhalt. The AfD won more than 20 percent, which at the time rightly provoked outrage and incomprehension in western Germany. Today, in 2026, the AfD is also polling at around 20 percent in western German states, but this no longer provokes outrage and incomprehension. Instead, it is now regarded as proof of democratic conviction and civilizational resistance. After all, in the east, it’s 40 percent!” “This allows people to continue feeling morally superior to the East, but the wiser course would be to admit: if something doesn’t happen soon, the West will turn AfD-blue too. Or bluish.” “But will anything happen? The truly depressing thing about election night was not so much the AfD leaders intoxicated by their own success. It was the representatives of the other parties, who once again said that they were utterly shocked, needed some time to digest the result and would, of course, not simply return to business as usual. The SPD, a former big-tent party, celebrated its ‘stable’ result of 9.3 percent. Congratulations!” “For 10 years, the AfD has gone from one electoral success to the next. And still, the established parties remain ‘shocked’ and scratch their heads in astonishment. How long can they keep being shocked? Friedrich Merz says he may need to communicate his reform ideas in a more ‘emotional’ way. So the CDU’s political professionals sit down together after the election, mull over a strategy, and in the end come up with this: Fritz, try to be a little more relaxed, charismatic and emotional – or something. Beyond that: no political plan, no defiance, no promise of a future. That is frightening.” What was good, what was bad for democracy? Good: Voter turnout in Saxony-Anhalt was 77.8 percent, the highest ever recorded in the state. Whatever one thinks of the result, that figure is encouraging. Democracy needs citizens to take an interest. Bad: Although a strong AfD result had been expected in Saxony-Anhalt, many politicians from the mainstream parties – including in Berlin – appeared confused, helpless and overwhelmed in their initial reactions. That is not how they will win back voters’ trust. Last Week’s Highlights: 🗳️ Meet the Germans Who Voted for the AfD: Why would voters in a country like Germany, with its Nazi past, vote for a right-wing party? It’s a question only an editor in Berlin could come up with. On the ground, the view is different. 🟦 How the AfD Wants to Expand Its Power Across Germany: The far-right AfD is planning to decimate public broadcasting in Saxony-Anhalt, revamp education and install extremists in positions of power. And it is eyeing victory on the national stage as well. 🕯️ The Continuing Reverberations of September 11: It was a generational shock, and the consequences can still be felt today - from massive surveillance and significant increases in presidential power to violent excesses at ICE. 🤝 “For Europe, Canada Is the Preferred Partner in Trans-Atlantic Relations”: In an interview with DER SPIEGEL, Canadian Finance Minister François-Philippe Champagne discusses his country’s failed trade deal with the US and why Canada is looking to Europe. 🏛️ The True Historical Roots of the AfD: During the Weimar Republic in the 1920s, there were numerous parties on the extreme right espousing “Germany first” nationalism. The Nazis may not be the best comparison for today’s AfD. 🌊 AfD in a Landslide: Merz Is the Wrong Leader for Germany: The right-wing Alternative for Germany won in a landslide in Saxony-Anhalt state elections on Sunday. What does that mean for the country at large? Thank you for your continued support and have a wonderful week! Subscribe Share Leave a comment Your SPIEGEL Substack Team Compiled and edited by Charles Hawley

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Sep 12 • 7:49 AM EDT • Politics • derspiegel.substack.com
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CCHD: Dr. Chad Anderson Awarded With Emerging Health Leader Award

The Christian County Health Department’s (CCHD) Public Health Administrator, Dr. Chad Anderson, has been honored with quite the accomplishment, as he was recently nominated, and awarded with the Emerging Public Health Leader Award by the Illinois Public Health Association (IPHA). Hart Media Group recently […]

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Sep 12 • 7:15 AM EDT • Health • taylorvilledailynews.com
FNF Week 2: Riverside Academy dominates Covenant Christian 55-20

Riverside Academy and Covenant Christian Academy faced off against each other on Friday Night.

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Sep 12 • 12:35 AM EDT • Sports • sports.yahoo.com
Extra Point, Week Three: Providence Christian hosts Bayshore Christian
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Sep 12 • 12:10 AM EDT • Sports • sports.yahoo.com
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Meet ARMI's Christy Johnson

Christy Johnson, director of education and workforce development for ARMI, says there’s no upper limit for educating people in STEM (Science, Technology, Engineering and Mathematics).

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Sep 11 • 8:30 PM EDT • Science • unionleader.com
CHRISTUS Health awards $300,000 in grants to Central Louisiana nonprofits

CHRISTUS Health awarded $300,000 in grants to five local nonprofits in Central Louisiana.

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Sep 11 • 8:04 PM EDT • Health • kalb.com
CHRISTUS Health awards $300,000 in grants to Central Louisiana nonprofits

CHRISTUS Health awarded $300,000 in grants to five local nonprofits in Central Louisiana.

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Sep 11 • 8:04 PM EDT • Health • kalb.com
Bob Bolus, Scranton political activist, philanthropist, dies at age 83

Bob Bolus, a tow-truck company owner, divisive political activist and Christmas dinner philanthropist, died late Thursday night in a hospital at age 83 from an illness, a longtime friend confirmed Friday. Earlier this year, the Scranton…

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Sep 11 • 4:01 PM EDT • Politics • thetimes-tribune.com
“Dark Knight” actor makes rare comment on moment he learned costar Heath Ledger died

Gary Oldman reflected on Ledger’s 2008 death, after he and the Australian actor starred in Christopher Nolan’s acclaimed “The Dark Knight” Batman movie.

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Sep 11 • 12:04 PM EDT • Entertainment • yahoo.com
James McAvoy reacts to Christopher Abbott’s casting as Professor Xavier in new ‘X-Men’ film (exclusive)

From one Xavier to another! James McAvoy is reacting to Christopher Abbott’s casting as Professor Charles Xavier in Marvel’s upcoming ‘X-Men’ film.

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Sep 11 • 11:46 AM EDT • Entertainment • ew.com
On the Move: Week of September 11

Steve PetersonIndigo LivingPromoted to senior maintenance service techniciansteve.peterson@hubbellrealty.com Emrah NebicIndigo LivingPromoted to maintenance service technicianemrah.nebic@hubbellrealty.com Alex BurdittHubbell HomesPromoted to sales manageralex.burditt@hubbellhomes.com Tonya AdamsIndigo LivingHired as property managertonya.adams@hubbellrealty.com Giselle RuedaIndigo LivingHired as leasing consultantgiselle.rueda@hubbellrealty.com Staesha ChristiansonIndigo LivingHired as property managerstaesha.christianson@hubbellrealty.com Miguel MayoraIndigo LivingHired as maintenance technicianmiguel.mayora@hubbellrealty.com Richard SefaIndigo LivingHired as maintenance technicianrichard.sefa@hubbellrealty.com Janiecia McCalebIndigo LivingHired as…

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Sep 11 • 7:00 AM EDT • Business • businessrecord.com
How to Cultivate Health and Harmony in Your Home

Three books on parenting.

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Sep 11 • 6:00 AM EDT • Health • christianitytoday.com
Christopher H. Palmer

Christopher H. Palmer is managing partner of Cullen and Dykman and chair of the firm’s banking and financial services department.

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Sep 11 • 1:00 AM EDT • Business • libn.com
As fall sports season gets under way, boys soccer team earns 9-1 win, girls team ties

Compiled by Matthew Christopher Haraden • Hull High School’s fall sports season is under way. The boys varsity soccer team opened its season with a 9-1 win over Norfolk County Agricultural High School on Tuesday. The Pirates face Tri-County Regional Vocational Technical High School at home on Fr

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Sep 10 • 6:15 PM EDT • Sports • hulltimes.com
Colorado doctors, dentists challenge state law on gender‑transition services in new federal lawsuit

A group of Christian doctors and dentists has filed a federal lawsuit challenging a Colorado law they say requires them to provide gender‑transition services that conflict with their religious and ethical beliefs. The lawsuit, filed by the Christian Medical and Dental Associations and Button Family Practice of Cañon City, alleges that certain portions of Colorado’s […]

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Sep 10 • 4:17 PM EDT • Politics • coloradopolitics.com
Drew Petzing reveals one worry with Lions offense vs Saints

Detroit Lions could rotate incumbent starter Christian Mahogany and veteran Ben Bartch at LG in their season opener Sunday against New Orleans Saints.

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Sep 10 • 2:05 PM EDT • Sports • sports.yahoo.com
Science Lab: Christian Parker’s task is tall, Cowboys' window is small

The 2026 season arrives with lots of pressure for the Cowboys, and that includes Christian Parker's defense being up against a shrinking offensive window in Dallas.

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Sep 10 • 12:00 PM EDT • Science • dallascowboys.com
Trump calls Luka Dončić trade one of the worst in sports history, suggests Mavericks ‘redo’ deal

Trump criticized the Mavericks' decision to swap Dončić for Anthony Davis, Max Christie and a first-round pick.

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Sep 10 • 11:44 AM EDT • Sports • nytimes.com
Patriot Mobile Sponsors 9/11 Remembered: 25 Years Later Documentary

Dallas, TX, Sept. 10, 2026 (GLOBE NEWSWIRE) -- Patriot Mobile, America’s only Christian conservative wireless provider, is honored to sponsor 9/11 Remembered: 25 Years Later, a new documentary commemorating the

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Sep 10 • 11:02 AM EDT • Entertainment • caledonianrecord.com
TCB Selects Christophe Beck as Its 2026 Person of the Year

Ecolab CEO Christophe Beck refuses to shrink from complicated and thorny problems. As the opponents to data centers have grown exponentially, Beck has become a major public spokesman on how to reduce the water and electricity used in the centers. As Minnesota’s economy has produced slow growth, Beck’s spoken bluntly about needed changes in the

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Sep 10 • 9:30 AM EDT • Business • tcbmag.com
Packers Take Notice As Harrison Smith Returns For Vikings

Christian Watson, Tucker Kraft and Matt LaFleur all acknowledged the impact Smith has on the Vikings’ defense ahead of Minnesota’s season opener against Green Bay.

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Sep 10 • 7:00 AM EDT • Sports • sports.yahoo.com
Analysis | Meet the lawmaker who’s worried about Christian nationalism

Rep. Jared Huffman is concerned about religious freedom.

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Sep 10 • 5:09 AM EDT • Politics • washingtonpost.com
My Science Job: Christian Thompson's resume includes designs for space gear

Christian Thompson, Quinsigamond Community College alum, struggled academically until a professor turned him toward manufacturing technology. He went on to design spacesuits at David Clark.

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Sep 10 • 5:01 AM EDT • Science • telegram.com
Mets Survive Marlins in Wild Shootout

Christopher Morel haunted his former team, while Francisco Lindor launched a crucial blast as New York withstood a furious late rally to outlast Miami in a high-scoring thriller and complete a three-game sweep.

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Sep 9 • 11:28 PM EDT • Sports • sports.yahoo.com
Gyokeres fails to elevate Gunners

Playing away in the Champions League, it is always going to be tough, but I think with Gyokeres, you can feel the difference when he is playing compared to when Kai Havertz is. "Arsenal created chances before that and Gyokeres created a chance or two himself, but Arsenal just felt like a different team when Havertz was in there, maybe because there were some more familiar faces coming on to the pitch as well, the likes of Christos Tzolis and so on, but they looked different and it felt different, it felt more familiar."

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Sep 9 • 6:29 PM EDT • Sports • sports.yahoo.com
MedStar Health Offers New Nonsurgical Weight-Loss Procedure

/PRNewswire/ -- For the first time at MedStar Health, patients struggling with obesity who may not want, or may not qualify for traditional bariatric surgery,...

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Sep 9 • 5:58 PM EDT • Health • prnewswire.com
World Cup created a ton of momentum for our business: FanDuel president

FanDuel President Christian Genetski discusses sports betting ahead of the NFL season and New York suing Kalshi over alleged unlicensed betting on ‘The Claman Countdown.’

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Sep 9 • 4:31 PM EDT • Business • foxbusiness.com
Jimmie Johnson | Racing Report

HIGH POINT, N.C. (WGHP) — This week on Racing Report with Chris Weaver, we’ll take a look at the opening race for the NASCAR Chase for the Championship that kicked off at Darlington Speedway with the Southern 500. We’ll chat with winning driver, Christopher Bell, who got his first win of 2026 and we’ll also […]

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Sep 9 • 1:56 PM EDT • Sports • sports.yahoo.com
Christian singer-songwriter to perform in Hershey: Here’s how to get tickets

The “God of Miracles” singer-songwriter will be at the Giant Center in Hershey in April.

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Sep 9 • 1:20 PM EDT • Entertainment • pennlive.com
Christie breaks new ground with hat-trick

Ryan Christie may not have been aware that he was making a little history while netting three times against Lincoln City in Bournemouth's Carabao Cup third-round tie. Tuesday's game was Bournemouth's 175th League Cup match since the competition was inaugurated in 1960, but Christie is the first Cherries player to score a League Cup hat-trick. Since his move to Dorset in 2021, Christie had found the net only 10 times for the Cherries before Tuesday, despite scoring six goals for his country in that same period.

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Sep 9 • 12:24 PM EDT • Sports • sports.yahoo.com
Walker, Smith, Varsho homers power Astros to 6-5 win over the Phillies

The Astros began the three-game series with a two-game lead on Texas atop the AL West.

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Sep 9 • 9:41 AM EDT • Sports • spectrumlocalnews.com
New development planned for Nashville’s Second Avenue as area continues rebuilding

Two historic buildings on Nashville’s Second Avenue are slated for a major transformation as the downtown street continues rebuilding nearly six years after the Christmas Day bombing.

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Sep 9 • 9:21 AM EDT • Entertainment • wkrn.com
Is Patriots CB Christian Gonzalez playing today?

What is Patriots cornerback Christian Gonzalez's game status for Wednesday's season opener against the Seahawks?

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Sep 9 • 6:31 AM EDT • Sports • sports.yahoo.com
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Devon Witherspoon responds to Christian Gonzalez trumping his historic deal

The wait has finally come to an end for Christian Gonzalez after he was rewarded with his record-breaking new deal by the New England Patriots. Whether the contract stand-off has had any effect on his preparations for Wednesday’s game in Seattle remains to be seen.

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Sep 9 • 3:20 AM EDT • Sports • sports.yahoo.com
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Milwaukee Brewers Announce Sudden Christian Yelich Decision During Cubs Series

The Milwaukee Brewers started their series with the Chicago Cubs on Monday night with a 4-3 victory. Milwaukee will now have their ace Jacob Misiorowski on the mound for Game 2 of the series Tuesday, while Chicago will pitch lefty David Peterson. Ahead of the game, Brewers manager Pat Murphy made a few notable tweaks […] The post Milwaukee Brewers Announce Sudden Christian Yelich Decision During Cubs Series appeared first on HEAVY.

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Sep 8 • 8:42 PM EDT • Sports • sports.yahoo.com
Helping Children Unlock the Science of Reading

For children who struggle to read, even a single page can feel like a puzzle everyone else already knows how to solve. Certified reading specialist and author Christie Welsby is helping families na…

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Sep 8 • 7:55 PM EDT • Science • kget.com
Kathy Griffin reveals Dolly Parton wrote letter admitting she was a secret fan

Kathy Griffin reveals Dolly Parton wrote her a letter admitting she was a secret fan, after Griffin requested she appear on ‘My Life on the D-List’: ‘You say the stuff I’m afraid to.’

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Sep 8 • 5:03 PM EDT • Entertainment • ew.com
U.S. Department of Health Announces Key Leadership Changes at FDA

Sept ⁠8 (Reuters) - ⁠The U.S. ⁠Department of Health ‌and ‌Human ⁠Services on ⁠Tuesday named four senior leaders at ⁠the U.S. ⁠Food ⁠and Drug Administration, including the ⁠heads ⁠of its drug center and ⁠vaccines and biologics unit. (Reporting by Christy ⁠Santhosh in Bengaluru; Editing by Tasim ...

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Sep 8 • 4:35 PM EDT • Health • usnews.com
Florida high school football coach fired after just three games

Dan Nieboer was hired away from Jason Witten's Liberty Christian staff in Texas to lead Lely (FL). After an 0-3 start, he's been let go.

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Sep 8 • 4:22 PM EDT • Sports • sports.yahoo.com
Beloved Hershey Christmas attraction won’t be returning this year

However, several new attractions will be included in the Christmas Candylane season at Hersheypark.

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Sep 8 • 4:17 PM EDT • Entertainment • pennlive.com
Dan Campbell Reveals Detroit Lions Guard Plan for Week 1

Dan Campbell is keeping Detroit's left guard competition alive entering Week 1. Christian Mahogany and Ben Bartch will split first-team practice reps, and both could see action against New Orleans.

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Sep 8 • 12:07 PM EDT • Sports • sports.yahoo.com
Clive Davis’ art collection heads to Christie’s auction

Clive Davis’ largely unseen art collection, featuring works by David Hockney and Andy Warhol, could fetch more than $35 million at Christie’s.

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Sep 8 • 12:01 PM EDT • Entertainment • latimes.com
Christal Jordan has the latest in entertainment headlines

The Duke & Duchess of Sussex are back in the UK, and Phaedra Parks has a new beau. Keep up with Christal on social media @threalchristaljordan

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Sep 8 • 11:11 AM EDT • Entertainment • fox5atlanta.com
Christal Jordan has the latest in entertainment headlines
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Sep 8 • 11:11 AM EDT • Entertainment • yahoo.com
Inside the Christian Gonzalez deal
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Sep 8 • 10:55 AM EDT • Sports • sports.yahoo.com
AZ's R&D chief Barr touts internal 'science success story' after IL-33 antibody's stellar showing in COPD

With a detailed data drop that AstraZeneca’s R&D chief described as an internal “science success story,” the British Big Pharma has secured an FDA priority review for what it believes could become a flagship biologic in chronic obstructive pulmonary disease (COPD). In detailed results from the late-stage Oberon and Titania trials—first teased in March and detailed in full at the European Respiratory Society Congress in Barcelona this week—the drugmaker laid out the extent of its IL-33 inhibitor’s potential to reduce moderate and severe exacerbations in a wide range of COPD patients still struggling with those “lung attacks,” as AstraZeneca’s Sharon Barr, Ph.D., called them, despite using standard-care inhaled therapy. In the headline results, a 300 mg dose of tozorakimab given once every four weeks curbed those moderate and severe exacerbations in the studies’ primary population of former smokers by 29% in the Oberon study and 34% in Titania. In the overall population of both current and former smokers, these reductions were 30% and 29%, respectively, versus placebo and inhaled standard of care. The benefits also extended to clinically meaningful exacerbation reductions in all prespecified patient subgroups and specifically turned up promising signals in patients across a range of blood eosinophil counts, with Barr telling Fierce that “it’s the details that make this even more exciting than the high-level results that we’ve already shared.” In fact, during AZ’s tozorakimab poster presentation at the ERS 2026 Congress this past weekend, attendees were so enamored by the data that event organizers had to encourage people to clear the room and look at the other presentations on offer, Barr said in an interview. “I think it really speaks to the fact that there is a lot of buzz around these data because the entire respiratory community has been so desperate for new therapies for these patients,” she explained. The respiratory disease continues to represent a “staggering unmet medical need,” Barr said, highlighting the COPD exacerbations that the Oberon and Titania studies homed in on, which she added carry a greater mortality risk than a heart attack. “When a patient has a severe exacerbation, only about half of them are still alive within three and a half years,” she pointed out. As for tozorakimab specifically, Barr christened the molecule “an AstraZeneca science success story,” harkening several years back to the point at which researchers began to explore IL-33 as a driver of respiratory disease, and COPD in particular. At the same time, “there was still so much that wasn’t understood,” she admitted, highlighting the insight that IL-33 signals through both ST2 and EGFR through the RAGE pathway, a discovery Barr attributed to AstraZeneca's own scientists. Understanding the need to tackle both pathways in COPD—and aware of competitor candidates in the hopper, including one that bound ST2—the company ultimately had to make some “courageous decisions,” Barr said. These included taking a prior COPD molecule offline and going back to the drawing board to reinvent its potential IL-33 label “to make sure that we had a molecule that could block signaling through both arms of the pathway, through both the reduced form and the oxidized form, knowing that we wouldn’t be first, but striving to be best.” “When we put [tozorakimab] into the clinic, we firmly believed that we had a differentiated molecule, and we saw the other molecules blocking just ST2 or partially blocking IL-33, unable to deliver two positive pivotal studies in COPD,” Barr explained. “We kept marching forward because we believed our molecule was differentiated, and now I think we have the clinical validation that supports that.” Ultimately, AstraZeneca finds itself on much better footing these days when it comes to potential biologic rivals to tozorakimab in COPD. Sanofi and Regeneron’s Dupixent, for instance, is approved to treat COPD exacerbations in patients with high eosinophil counts, but not low ones. Meanwhile, the future has become cloudier for other next-gen IL-33 candidates from Sanofi and Regeneron, as well as Roche, which have suffered trial flops in recent years. One other potential ingredient for AstraZeneca’s success in its duo of studies was that the company was “ambitious in the trial design, willing to look at an all-comers population,” Barr said, “and willing to enroll the most severe patients.” Prior studies for would-be biologics rivals in COPD “avoided enrolling” those patients, she pointed out. She also highlighted the Big Pharma’s painstaking design of exacerbations in its trial, which “gave us a very rigorous readout,” and pointed to “the extra effort and investment” the company put in to understand the effect of mucus plugs in patients. Barr described mucus production as a “key feature in disease diversity,” noting that mucus plugs—obstructing clumps of mucus that block patients’ airways—are associated with worse outcomes in COPD. In its data announcement, AstraZeneca noted that an integrated analysis of Oberon and Titania found tozorakimab “demonstrated a reduction in patients’ mucus plug score,” with the pharma claiming its biologic is the first to deliver such results in a broad COPD population. “So being able to reduce those mucus plugs, we expect, is an important part of driving benefit for patients who are living with COPD,” Barr said. Again touching on the breadth of the study populations, Barr added that tozorakimab “worked across all eosinophil levels in both current and former smokers across all levels of lung function,” which she suggested “really simplifies decision-making for clinicians, and it allows them to offer therapy to the broadest possible patient population.” In the highest patient eosinophil count group, tozorakimab helped chart a 43% reduction in exacerbation risk, which Barr stressed were “unprecedented data.” In the mid-level group, AZ’s drug delivered a 23% reduction and, in the lowest group, a 34% reduction in eosinophils, which Barr said suggests efficacy “in all patient subgroups.” As for AZ’s recent guidance upgrade on the medicine’s sales opportunity, the lift from a $3 billion to $5 billion range to $5 billion plus was informed by multiple factors, Barr said, including the fact that “in 2024, there were multiple competitors, and there aren’t anymore.” Additionally, “we know that this is a massive unmet medical need, and this is a really incredible set of data that we think will be very convincing to the clinical community,” Barr said. Looking ahead to a potential evolution of the COPD treatment landscape, Barr noted that most patients start treatment in the community with an option like a triple therapy, and for them, having an option like AstraZeneca’s inhaler Breztri will remain a “really important part” of that journey. But of the patients uncontrolled on triple therapy, which Barr described as “about half of them today,” just a “small fraction” are currently eligible for biologic therapy, which she emphasized AstraZeneca is working to change. Understanding that COPD is not a “one-size-fits-all” disease, AstraZeneca is also looking at its antibody drug Tezspire for patients with T2-driven disease, and the company continues to think about new mechanisms for tackling COPD through both systemic and inhaled drugs, Barr said.

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Sep 8 • 10:50 AM EDT • Science • fiercebiotech.com