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How Machines and Magnets Taught Science a New Way to Explain the World
A new historical analysis argues that cognitive science and statistical physics independently converged on a shared simulative methodology, the synthetic method, as the only viable path to understanding complex systems.
MSFT Stock On 4-Day Winning Streak: Microsoft Takes On Apple's Macs With Nvidia-Powered Surface Ultra, More On-Device AI
Microsoft is pushing Windows deeper into the local-AI era with Nvidia-powered Surface, on-device models and hybrid Copilot features.
US grants Aurora exemption for self-driving trucks safety feature
The U.S. Transportation Department said late Wednesday it approved a five-year exemption for Aurora and other self-driving trucking companies from rules that require drivers to place warning devices around a stopped truck.
Hawaii Business Magazine features women leaders in Hawaiʻi's tech industry
Hawaii Business Magazine’s Jennifer Ablan and Grant Nakasone talk about their 2026 Wahine Issue focusing on women in the workforce.
Raiders Week 5 vs Patriots features Super Bowl LX rematch
The Patriots will face another Super Bowl rematch this week when the Raiders come to town.
Discover Long Island revamps website for visitors, locals
Discover Long Island has launched a redesigned website aimed at providing an immersive and user-friendly experience for both visitors and locals. The site incorporates AI-driven features, improved navigation and local storytelling to showcase Suffolk County and regional attractions, with plans to add international translations and itinerary-building tools in the future.
Someone Rebuilt Free, Open-Source Versions of Photoshop, Premiere, and Lightroom Using AI
People are excited for open-source Adobe alternatives.
NASA’s Curiosity Captures Dawn Breaking on Wind-Carved Cliffs
NASA’s Curiosity Mars rover captured this panorama of sunrise illuminating distant, wind-carved features called yardangs on Aug. 11, 2026, the 4,982nd Martian
P.T. Native PC Port 1.0 Is Out Now With DLSS 4.5, Frame Generation, Ray Tracing, Mods, And More
Hideo Kojima,P.T.,PlayStation 4,LoreanXavier,Vulkan,Konami,NVIDIA DLSS 4.5,AMD FSR 3.1,Intel XeSS,Silent Hills
Beyond hours saved: Building the business case for agentic automation
The RPA-era ROI model misses most of the value agentic automation creates. This post gives AI center of excellence leaders a framework to size the full value of agents across time savings, exception handling, decision quality, and maintenance economics, and to prioritize which workflows to automate first.
NYC Health + Hospitals Leaders Named to Becker's 2026 "Rising Stars: 188 Healthcare Leaders to Know Under 40" List
NYC Health + Hospitals announced that Komal Lodaria, Senior Director of System Care Experience, and Christopher G. Wilson, MSN, RN. Chief Nursing Officer,
iOS 27.2 release date: New iPhone features are coming soon
iOS 27.2 is coming surprisingly soon, with iOS 27.1 focusing solely on iPhone Duo changes, Here’s when to expect the update’s release.
What Do Health and Wellness Influencers Post About?
Just over half of health and wellness content on social media focuses on healthy living, while about a third discusses medical topics. And 38% of posts have a product or service promotion.
I ignored the Windows app until Microsoft closed this major feature gap
Remote PC connections are now generally available alongside Windows 365, Azure Virtual Desktop, and Dev Box access.
Film Festival Will Screen ‘Beyond The Duplex Planet’
The Woods Hole Film Festival’s Dinner & A Movie series continues on Saturday, October 17, with “Beyond The Duplex Planet,” a new feature documentary by Emmy-winning, Grammy-nominated filmmaker Beth Harrington.
Crafts in Cars Street Fair showcases art and entertainment
The weekend event featured over 40 vendors selling different handmade goods.
UNDER THE RADAR: '27 Springdale DL Alvaro Rodriguez
On Wednesdays we feature an in-state prospect who could be flying under the radar of college coaches.
Teladoc unveils remote monitoring, ambient AI features
The company’s virtual care platform has integrated artificial intelligence scribing and camera-based vitals monitoring as it works to recover from significant financial setbacks.
Google Messages is quietly ditching a key RCS feature users rely on
There is no clarity when it will be removed, though
Pilot Project Aids Cancer Survivors in Achieving Healthy Weight and Reducing Recurrent Risk
New program will help patients improve fitness and manage weight after cancer treatment
Takeaways from the Maine Senate debate between Susan Collins, Troy Jackson
The debate in a race for a critical Senate seat featured lots of talk about President Trump, high prices and the war in Iran.
LG Making Doorbell, Lock, and Cameras for Apple's Home Hub
Apple is working with LG Electronics on smart home accessories that will integrate with the upcoming home hub and other Apple home products, reports Bloomberg. LG is making a wired video doorbell, thermostat, smart deadbolt lock, temperature sensor, indoor security camera, outdoor security camera, and floodlight camera, according to documents LG submitted to the Federal Communications Commission and UL Solutions.
Google sounds really excited about 'massive' feature update hitting Pixel Buds right now
From dynamic ANC, to tap-to-mute for your microphone, to even new Live Translate capabilities, this sounds like one major update!
ARG Industrial Promotes Director of Sales
Anchorage-based hose, belt, and rigging supplier ARG Industrial promoted Regional Sales Manager Gordy Burks to Director of Sales.
Anderson and Guéhi help England to comfortable Czechia win
Elliot Anderson and Marc Guéhi both featured as the Three Lions beat Czechia 3-0 to complete the October international break.The night at Wembley began with Harry Kane forcing the own goal from forme...
Stand Up for Science to Rally Scientists & University Leaders in Support of Academic Freedom Tomorrow
Virtual rally features speakers from SUNY & SUFS; calls on university leadership to defend academic freedom.
Stand Up for Science to Rally Scientists & University Leaders in Support of Academic Freedom Tomorrow
Virtual rally features speakers from SUNY & SUFS; calls on university leadership to defend academic freedom.
Garmin's New Smartwatch Has Battery Life That Laps the Apple Watch Ultra 4
The Garmin Enduro 4 promises up to 320 hours of battery while still offering the health and fitness tracking features of the Fenix 9 Pro.
Focus Features Takes Global To Ice Cube & Tommy Lee Jones ‘Outside Man’ From Brian Helgeland
EXCLUSIVE: Focus Features has acquired worldwide rights to Oscar-winning filmmaker Brian Helgeland’s Outside Man. Deadline first told you about the Teton Ridge Entertainment production back in April w...
Three Years of 80% Charge Limits on iPhone: The Results
Since 2023, Apple's newer iPhones have had an 80 percent charge limit for those who want to extend battery lifespan. Charging to 80 percent instead of 100 percent is supposed to put less stress on the battery, improving longevity. For the last three years, I've used that setting on my iPhone. I started with the iPhone 15 Pro Max, then did the iPhone 16 Pro Max, and most recently, the iPhone 17 Pro Max.
Apple killed the Mac mini's best hidden feature [Video]
With the release of the M6 Mac mini and its more powerful M5 Pro counterpart, Apple quietly killed off one...
Monica Byington featured at Local Artists Gallery
Monica Byington, a long-time member of the Local Artist Gallery, has been chosen as Artist of the Month for October.
TCU Recognizes New, Newly Endowed Faculty for 2026-2027
Here, TCU News features newly endowed deans, chairs and professors for 2026-2027 as they navigate their first full year in their new roles. TCU thanks its generous donors and congratulates these deser
Googlebook "Better Together" phone features don't work with Samsung at launch
Googlebooks require Android 17, but Samsung's Android 17 phones won't work yet.
Want To Know If Someone Likes You? Science Suggests A Key Vocal Feature Can Reveal Who We Like, And Influence Who Likes Us
Interestingly, in works differently for long- and short-term relationships.
NASA’s Curiosity Rover Catches Stunning Martian Dawn
A newly released panorama captured by NASA’s Curiosity rover offers the most detailed view yet of distant, wind-carved Martian cliffs, highlighting features
Apple TV 4K Rumored to Support Four HomePods for Surround Sound
Last month, a proven leaker revealed that Apple has tested the ability to connect four HomePods to an Apple TV 4K for surround sound, with the HomePods intended to be arranged in front-left, front-right, rear-left, and rear-right positions. Now further evidence of this functionality has surfaced ahead of an announcement from Apple.
Students Use Forensic Science Skills in Escape Room
Hundreds of students from across the region put their problem-solving skills to the test this week during the Regional Science Consortium’s annual Forensic Science Escape Room. Elementary school students had just a few hours to figure out how someone died as part of a forensic science escape room activity. The Regional Science Consortium partnered with Mercyhurst University for the 10th year of the event, which is taking place at the Tom Ridge Environmental Center. It began Monday and runs through Thursday.Throughout the week, more than 250 students are working to solve murder mysteries using real forensic science techniques. Students must analyze the evidence, piece together clues and solve the crime before time runs out.Organizers said the event gives students interested in pursuing forensic science in college a firsthand look at what a career in the field could entail.Sarah Skelton, Special Gifts Coordinator at Iroquois, said the activity provides students with an opportunity to develop skills that can sometimes be difficult to practice in a traditional classroom. "It really helps them to work in teams and on critical thinking skills. Which, not that they don't get these opportunities, but it's hard sometimes in the classroom to develop those higher-level thinking skills”, said Skelton.Students also get a chance to learn how forensic science is used in real-life investigations. As Skelton explained, "What are the real-life applications? What would you actually see in a crime scene? How would you handle these types of forensic investigations? So it's really cool our kids get to see what opportunities are out there and possibly a career field one day."The popular event has grown over the years, with some students returning year after year. Organizers said watching those students grow and develop their interests is one of the highlights of the program.Jeanette Schnars, the Executive Director of the Regional Science Consortium said it's rewarding to see how students' interests evolve as they get older. According to Schnars, "How they have grown and matured and where their interests are going and maybe they aren't going into forensics, but if they are going into sciences or different disciplines, so it's really fulfilling to see how they have matured."One student who continues to enjoy the event is sixth-grader Mia Harvey of Iroquois. Harvey hopes to pursue a career in medicine and says the forensic science activities are helping her explore her interests, "One day I want to become a neurologist, and learning about the bones is probably going to help me."Harvey said her favorite part of the event is the real-life application of what she's learning. "While you are trying to find the clues, they teach real stuff that you would need to know”, said Harvey.Event organizers said if students are learning while having fun, then the program is accomplishing its goal. "Not only are they learning the science, but they are having fun with it too”, said Schnars.Adults will also have a chance to take part in the experience this Saturday during an adult version of the escape room, which will feature food, drinks and entertainment. For more information, click here.The Forensic Science Escape Room has become one of the Regional Science Consortium’s most popular events, with teachers signing up their students as soon as registration opens in August.
Candlelit Concert In Eastham Will Feature Guitarist Derek Gripper
Internationally acclaimed South African guitarist Derek Gripper will play a candlelit concert at Chapel in the Pines in Eastham on Wednesday, October 14, at 7 PM. The concert is part
Here’s what iPhone Duo’s new two-page PDF experience looks like
We continue to learn more about iPhone Duo’s feature set, with the latest reveal a preview of the two-page PDF viewing experience on the Duo.
Googlebook’s Android-integrated features won’t work with Samsung phones at launch
Googlebook is here with Android integration as its main pitch, but Samsung users are left out at launch as Galaxy devices aren't supported yet
Windham business leaders sound off on townwide issues
The event, hosted by the Windham Economic Development Corp., featured wide-ranging discussion.
Leaks reveal new Apple TV 4K and HomePod features coming next week
Leaks in the latest Apple software reveal several new Apple TV and HomePod features expected to be unveiled.
Google ‘Fitbit Edge’ reportedly costs around $180 as specs & features leak
A new leak reveals that Google’s upcoming Fitbit Edge tracker will probably have a price somewhere around $180 and offer...
'Captaincy ends': Harmanpreet Kaur’s top five achievements as India captain
Harmanpreet Kaur has stepped down as India’s all-format captain after a landmark leadership stint. Her tenure featured India’s maiden ODI World Cup title in 2025, a record number of T20I wins as captain, four Asia Cup triumphs, the milestone of captaining 150 T20Is and a historic Test victory at Lord’s. She now returns to playing cricket.
Catalytic confessions and a quest for Matt Damon: PodCAT puts science on mic
PodCAT, hosted by researchers from Rice, the University of Rochester and Penn State University, is a podcast devoted to the science of catalysis, academic careers and the surprisingly personal stories of the researchers themselves.
Terance Mann featured in 9.1% of trades built on …
Terance Mann featured in 9.1% of trades built on …
UK probes Meta over risk assessment of Instagram Instants
Britain's communications regulator said on Tuesday it has opened an investigation into whether Meta Platforms breached UK online safety laws by failing to properly assess risks posed by its Instagram Instants feature before launching it in May.
2026’s Biggest Blockbuster Games Just Received Their First Major Discounts in Amazon’s Prime Sale, but These 48-Hour Deals Won’t Last Long
Amazon's latest Prime Day sale features massive discounts on PS5, Switch 2, and Xbox titles, including deals on 2026's biggest games like The Blood of Dawnwalker, Star Wars: Zero Company, Pragmata, LEGO Batman, and more.
Main Street festival kicks off Wednesday
Event will feature concert with Neon Daisy
8 Fermented Foods To Add to Your Diet
Fermented foods like pickles and kimchi can help keep your gut health. An expert shares which foods are worth adding to your meals.
Fantasy football IDP free-agent report: Week 5
This is our weekly Waiver Wire feature depicting the best individual defensive players to target on waivers in fantasy.
Signs of the times: Kodo Arts to showcase antique Japanese signs
The upcoming Kodo Arts Warehouse Sale Oct. 10-18 will feature an unusual collection of Japanese 'Kanban' or traditional shop signs from the 1800's and 'Tairyo-bata' fishing boat flags flown to
Two more Final Cut animations on Warhammer TV this week
Plus, new episodes of Loremasters, Tale of Four Gamers, and How We Roll.
NYC Health + Hospitals/Queens Hosts Community Health Fair as Centerpiece of Hispanic Heritage Month Celebrations
NYC Health + Hospitals/Queens hosted a comprehensive Community Health Fair on September 30, serving as the primary event in the hospital’s month-long
Chip City closes all locations amid economic challenges
Chip City, a New York City-based gourmet cookie chain, has closed all 22 remaining locations nationwide due to tough consumer spending and evolving preferences.
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Yes on Prop 2: How We Can Get Money Out of Michigan Politics!
This November, Michiganders can vote yes on Prop 2 and get corporate spending — including by the data center industry — out of our politics.
NYC Health + Hospitals/Woodhull Marks Simulation Week with Hospital-Wide Training to Advance Patient Safety and Clinical Readiness
NYC Health + Hospitals/Woodhull celebrated Simulation Week on September 25 with an interdisciplinary simulation event designed to strengthen
Doyon Foundation Selects New Executive Director
Doyon Foundation selected Geraldine “Geri” Simon, a Doyon, Limited shareholder from Allakaket, as the nonprofit’s Executive Director.
Supreme Court kicks off new term with major climate case
The Supreme Court returns for its new term on Monday, and oral arguments in a major case over the fate of a costly climate change lawsuit brought by Boulder County, Colorado, will kick off a term set to feature several blockbuster legal battles. Suncor Energy v. County Commissioners of Boulder County will decide whether a […]
Business Insider expands Discourse team and hires Arielle Pardes
Our Discourse team, led by executive editor Zak Jason and focused on agenda-setting topical features, is expanding.
Politics on Stage. Wonderful Life on Broadway. Jeremy O Harris to Mamdani: Call me. Stageworthy News of the Week.
On stage during the first week of October: Plays about the Epstein Files. Gun violence. Black women silenced. Complicity. Sexism. Homophobia. This seems an unusual burst of political theater even f…
Can Health Trackers Help You Manage Menopause Symptoms?
Apple, Oura and Whoop have all recently added features for midlife women. Here’s what the tools can — and can’t — measure.
Apple Releases MagSafe 3 Charging Cable Firmware Update
For the first time since February 2023, Apple has released a firmware update for the MagSafe 3 charging cable for the MacBook Pro and MacBook Air. Specifically, Apple last week released firmware version 3.2.0 for the USB-C to MagSafe 3 Cable. The previous firmware version for the cable was 3.1.12. It is unclear what is included in the latest firmware, as Apple does not publish release notes for this.
The AI Advantage Minnesota Has Been Building for Decades
Software companies used to defend themselves in a handful of reliable ways. They built useful features, made their products easy to use and counted on the hassle of switching platforms to keep their customers from leaving. A new company that wanted to compete had to invest months, sometimes even years, of engineering time to catch
Mac Users Reclaim Storage With New Apple Intelligence Removal Tool
A new open-source tool is making waves in the Mac community by helping users reclaim valuable storage space taken up by Apple's AI models. Called "RemoveMacAI," the tool disables Apple Intelligence on macOS 27, removes its downloaded models, and prevents them from being downloaded again. In macOS 27, Apple removed the toggle to disable Apple Intelligence wholesale, and simply disabling individual features doesn't remove the models from your Mac's drive.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
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