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76ers will likely apply and get awarded a $1.7M …
76ers will likely apply and get awarded a $1.7M …
SUN: Orioles make layoffs within business ops ahead of expected MLB lockout
The Orioles laid off multiple employees from their business operations department Tuesday, according to an internal memo obtained by The Baltimore Sun that pres
Orioles make layoffs within business ops ahead of expected MLB lockout
The Orioles made cuts to their business operations staff Tuesday, just over a week after their 2026 season ended.
NFL Drops Hammer With Punishment Over Denver Broncos Game
The NFL has stepped in with costly discipline over an in-game altercation involving Denver Broncos head coach Sean Payton. The post NFL Drops Hammer With Punishment Over Denver Broncos Game appeared first on HEAVY.
Minneapolis shops invite customers for Latino business week as many recover from ICE surge
Minneapolis celebrates its third annual Latino Business Week this week, as many Latino-owned shops around the city continue recovering from losses during the federal immigration enforcement surge.
Pikachu spent 67 days in space
To celebrate World Space Week, the ESA and Pokémon are joining forces.
Spurs believe Dylan Harper is their second-best player?
Spurs believe Dylan Harper is their second-best player?
Miley Cyrus’ new album “Bass Persuades” shockingly suffers one of the biggest drops from No. 1 in chart history
The “Hannah Montana” icon’s latest LP took a massive dip in its second week.
Bullfrogs have a brain superpower
Understanding their backup brain fuel could help treat human neurological diseases.
New on DVD: Get ready to mingle with 'DTF St. Louis'
Last month's Emmy winner for best limited series tops the DVD releases for the week of Oct. 13. "DTF St. Louis": HBO's seven-episode drama stars Jason Bateman as TV weatherman
Vanilla could help heal wounds
A compound in vanilla pods has anti-inflammatory, antibacterial, and antioxidant properties.
Raiders news: Fernando Mendoza using his business chops off the field
Las Vegas rookie quarterback has business passion
Raiders news: Fernando Mendoza using his business chops off the field
Las Vegas rookie quarterback has business passion
Victor Wembanyama says he was inspired by the unity …
Victor Wembanyama says he was inspired by the unity …
Compass Datacenters Funds New Community Wellness Space at Hoffman Estates Health and Human Services
$50,000 investment will create the department's first purpose-built room for group therapy, workshops and community programming Compass Datacenters is funding...
Prime Big Deal Days: 50+ actually good deals on stuff you really want (updating)
Prime Big Deal Days is live. AirPods Pro 3 are $179, KitchenAid's bowl-lift mixer is $299.99, and a self-emptying Shark robot vacuum is $249.99.
The Knicks have offered four years and approximately …
The Knicks have offered four years and approximately …
Terance Mann featured in 9.1% of trades built on …
Terance Mann featured in 9.1% of trades built on …
Curiosity Blog, Sols 5029-5035: Back in the Lab
Written by Michelle Minitti, MAHLI Deputy Principal Investigator
Brian Greene stops teaching Frontiers of Science after more than a decade
Brian Greene, a prominent theoretical physicist and popular science commentator, has stopped teaching Frontiers of Science, according to the course’s fall 2026 syllabus reviewed by Spectator.
Sacramento entertainment spot tops list of best escape room in the United States
Three other California escape rooms also made the list by USA Today.
Hawkeye Women Land Athletic Center Khalia Hartwell From 2027 Class
Fans of Iowa women’s hoops should be very excited about some of the recruits that are saying yes to the black and gold in the post Caitlin Clark era. Jan Jensen has had some of the very best high school players expressing serious interest in Iowa and has convinced a few of them to commit. […]
Budding food scrap businesses want your coffee grounds and eggshells
Composting leftover coffee grounds, eggshells and carrot tops is a way to reduce the amount of food waste that goes into landfills, where it produces the potent greenhouse gas methane
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Dead star likely birthed a new planet, in astronomical first
A white dwarf probably created a rare ‘second-generation’ planet.
Lamar Jackson Drops 1-Word Reaction As Sports Doctor Assesses Ravens QB’s Ankle Injury
Lamar Jackson offered a brief response after a sports doctor weighed in on his ankle injury during Sunday’s win over the Tennessee Titans. Dr.
Florida running back apologizes to coach after disappointing game
Florida Gators running back Jadan Baugh entered Saturday’s game against the Missouri Tigers as a legitimate Heisman Trophy contender. Unfortunately for him and the Gators, he didn’t exactly perform that way on Saturday. Now, he’s apologizing directly to his coach. Just a week after a lopsided win over Ole Miss thrust the Gators into the…
Nic Claxton out two weeks with hamstring injury
Nic Claxton out two weeks with hamstring injury
57 new species discovered in deep-sea canyon near Argentina
Including ‘Loki the Sea Cucumber.’
LeBron's use of a Fanatics branded helicopter is part …
LeBron's use of a Fanatics branded helicopter is part …
“It’s a lot that happened,” Garland said. “But this …
“It’s a lot that happened,” Garland said. “But this …
Greenfield Business Association distributes inaugural Buzz Awards
Greenfield Business Association held its first Buzz Awards at Four Phantoms Brewing Co., celebrating local shops like Hope & Olive and Freedom Cafe.
"I think just with the playoff time and watching, that …
"I think just with the playoff time and watching, that …
Why .670 OPS outfielder 'won't be back' with Mariners
This seems like an unlikely reunion for the Mariners.
Extinct ice age bovine discovered in Siberian cave
Bone fragments show this yak-like animal likely went extinct about 27,000 years ago.
Soldiers wounded in Iranian drone strike say military medical system failed them
The attack on the second day of the U.S. war with Iran killed six troops and injured dozens
Giannis Antetokounmpo: 'I got five, six good years'
Giannis Antetokounmpo: 'I got five, six good years'
Chimpanzees steal less pineapple from their friends
The new research sheds more light on the evolutionary origins of friendship.
“It definitely stuck with me for a bit,” Fox said. …
“It definitely stuck with me for a bit,” Fox said. …
Building something with your hands — and a career
MakerSpace NYC is one of at least 2,000 community workshops across the country.
International Coalition Endorses Kyoto Vision For A Golden Age Of Science
An international coalition of 17 countries have endorsed the Kyoto Vision for a Golden Age of Science. A joint declaration issued at the 23rd Annual Meeting of the Science and Technology in Society Forum held in Kyoto, reflects a shared ambition to renew and strengthen our science ecosystems and usher in a golden age of discovery and prosperity.
Move over kimchi, natto is appearing in health food shops everywhere
Japan’s smelly, slimy beans are highly nutritious but you’ll need ‘nerves of steel’ to eat them
THIS WEEK: “Sick of It! Fix Health Care Now” Bus Tour Kicks Off With Stops in Maine, New Hampshire, New York, Pennsylvania, New Jersey
Rep. Maggie Goodlander (D-NH-02), PA Lt. Gov. Austin Davis Will Headline “Sick of It! Fix Health Care Now” Events in Five States Watch All Bus Tour Stops Live Here. Washington,...
25 Years of Business Income Insurance Coverage Claims Since the Attacks of Sept. 11, 2001
The 9/11 attacks reshaped business income insurance, spurring decades of litigation over loss calculations, restoration periods, expert evidence, and terrorism coverage. These disputes continue to influence claims and policyholder protections after major catastrophes.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Asked about his previous approach to the time before …
Asked about his previous approach to the time before …
“It’s been very, very helpful those days or weeks …
“It’s been very, very helpful those days or weeks …
“I’m probably way more confident than my surgeon, the …
“I’m probably way more confident than my surgeon, the …
Kathleen Turner Has An Iconic Response As Michael Douglas Admits To Past Affair
“What a fuss...”
Rockstar Traveled Across Florida With Gang Members and Cops for GTA 6 Research
Rockstar has discussed travelling across Florida with gang members and cops for GTA 6 research, and hovering in a helicopter above a Beyonce concert.
‘An agenda of…’ – Joe Burrow’s ex-teammate drops a ‘politics’ accusation on Chargers’ Mike McDaniel
Mike McDaniel is being blamed for the Los Angeles Chargers’ terrible start to the 2026-27 NFL season. Week 4 of the NFL season didn’t go as planned for the Los Angeles Chargers, as the organization was handed its fourth defeat of the year.
Mitch Johnson on Tobias Harris’ calf strain: “It’s a …
Mitch Johnson on Tobias Harris’ calf strain: “It’s a …
Euro drops to 17-month low as political and fiscal risks rise
Euro hits 17-month low as French politics and fiscal worries shake markets.
China develops plant to extract hydrogen, fresh water and uranium from the sea
Scientists improve on existing technology, plugging an overlooked energy leak to achieve a potentially profitable green solution.
Patriots’ HC Raves About Drake Maye Compared to Josh Allen
The New England Patriots needed a response after a lopsided loss. Head coach Mike Vrabel received one from his quarterback against a division heavyweight. New England stunned the previously unbeaten Buffalo Bills 29-26 on Sunday, Oct. 4, and Vrabel placed Drake Maye in the same conversation as reigning NFL MVP Josh Allen afterward. “Gets us […] The post Patriots’ HC Raves About Drake Maye Compared to Josh Allen appeared first on HEAVY.
Oldtone Music Festival returned to Hillsdale
Oldtone Music Festival drew bands, dancing and workshops at Cool Whisper Farm, celebrating roots music and traditional folkways.
Anti-Woke Sports Bro Cut From College Football Fan Favorite
The Barstool Sports founder blamed his rival team for Fox Sports’ decision.
El-Sayed stops in Flint, discusses economic pressures and failures
U.S. Senate Democratic candidate Abdul El-Sayed made a stop in Flint Saturday as a part of his 'It shouldn't be this hard' town hall tour.
Scientists Find A Molecular Clue That Could Explain Why Weight Comes Back
Anyone who has lost a lot of weight knows the cruel part can come later. The scale drops, clothes fit again, and the hard work seems to have paid off. Then the pounds begin creeping back, sometimes al...
Jalen Duren on contract talks: 'I grew my knowledge of the business side of the game'
Jalen Duren on contract talks: 'I grew my knowledge of the business side of the game'
Jalen Duren mentioned a few times that he's learned …
Jalen Duren mentioned a few times that he's learned …
Asked Jalen Duren what his main emotion is: "I would …
Asked Jalen Duren what his main emotion is: "I would …
Duren started with a long, written statement accepting …
Duren started with a long, written statement accepting …
Florida appears set to tumble while Bama hopes to rise
A week after a huge promotion in the poll, Florida is bound to come down in the newest AP Top 25 after a lopsided loss. 25 Missouri on a Saturday while other ranked teams generally won in workmanlike fashion.
Gypsy Rose Blanchard Is Advocating For Stricter Online Harassment Laws After Fiancé's Death
Ken Urker was found dead on his 34th birthday at his home in Louisiana.
Wildlife camera in Guatemala captures a once-in-a-decade snapshot
The recent photographs confirm that jaguars are still traveling along an important wildlife corridor.
LAUP connects Latino families with mental health support in Holland
LAUP in Holland connects Latino families with mental health care through therapy and monthly workshops, addressing stigma, language barriers and cost while helping participants rebuild confidence.
I'm a classic old school Conservative, says Kemi Badenoch
The Conservative leader tells the BBC the earnings threshold for government support stops people "working harder".
Bobby Portis says him and Giannis playing for the …
Bobby Portis says him and Giannis playing for the …
What's the point of beards?
Women don't necessarily think men with beards are more attractive.
This Sneaky App Is Probably Sucking Up Your iPhone Storage. Here's How To Free Up Space.
This easy fix will give you more data on your device so you can go back to screenshotting every meme you see.
Popular eye drops sold at Walgreens recalled over sterility concerns
Walgreens-branded eye drops are among nearly 750,000 eye-care products recalled after the manufacturer cited a lack of assurance of sterility
Costa’s coffee shops return to profit with iced drinks and matcha on the menu
Costa Limited reports operating profit of £20m in year to 31 December 2025 after losses of £13.5m in 2024
It's Your Business | New Urbana shop aims to encourage reuse, creativity and community
In addition to reselling items, See Use Again also offers tool and mobility aid rentals, professional organization services, and workshops in partnership with artists.
A tale of two AAA games: Control Resonant shows what gaming can be, Marvel’s Wolverine shows what it is becoming
News, Reviews and other Informations about Laptops
Paul Reubens memorabilia, including Pee-wee Herman props, up for auction
Hundreds of pieces of memorabilia from late actor Paul Reubens’ personal collection, including props from “Pee-wee’s Playhouse,” “Pee-wee’s Big Adventure,” and other films, are being auctioned off …
Saturday's Connecticut high school sports roundup: East Lyme boys soccer tops Lyme-Old Lyme
A look at the Connecticut high school sports scene for Saturday, October 3, 2026.
Health Policy Watch | COVID-19 drops out of world’s top 10 causes of death for first time since pandemic began
The virus directly killed an estimated 0.9 million people in 2023, ranking 14th, as global life expectancy climbed back to near its pre-pandemic level.
Drake football tops Davidson 30-22 in Des Moines
Drake football tops Davidson 30-22 in Des Moines
Jordan Ott talked about Kennard's movement shooting …
Jordan Ott talked about Kennard's movement shooting …
His introductory press conference is tomorrow, Oct. 4, …
His introductory press conference is tomorrow, Oct. 4, …
13 unbelievable child car seats from the past century
Some were even on the outside of cars, because what baby doesn't want a view?
SnakePit Post-season GDT, #4
Whoops, didn’t expect today’s games to get under way quite as early as they did. The White Sox vs. Guardians game is already under way in Cleveland, but there’s currently no score at the end of the third inning. So it’s not as if we missed much. A full slate of four Division Series games […]
NFL Week 4 betting advice: Giants-Cards picks and props
Giants-Cards wagers to consider as you fill out your tickets.
Oklahoma high school football games ends in massively lopsided scoreline
Bixby won its 21st game in a row in stunning fashion, taking down Westmoore 80-0 behind a near-perfect game from QB Reece Madden.
What happened to Seattle’s dinosaurs at the Pacific Science Center?
A triceratops and stegosaurus, which have waded in PacSci’s now-empty reflecting pool for 35 years, were removed this month.
Whales can't hear each other in the noisy ocean. This inventor has a solution 200 years in the making.
A new type of boat propeller could turn down the volume.
“It is negotiation, it is business, but there has …
“It is negotiation, it is business, but there has …
The Knicks, per sources, are prioritizing a center.
The Knicks, per sources, are prioritizing a center.
Artists remember veteran concert producer Susan Lim and her decades in entertainment
Photo from Facebook/@susan.o.lim Artists and colleagues are remembering veteran concert producer Susan Lim for a career that spanned Philippine productions and overseas tours for Filipino performers. Lim died Sept. 14. Pops Fernandez, Martin Nievera and Roderick Paulate were among those who later shared public tributes, recalling both her work in entertainment and their longtime friendships with her. Lim had been active in…
Arkansas volleyball drops second straight SEC match at Georgia
The Arkansas volleyball team lost its second straight SEC game, falling to Georgia 3-1 on the road Friday.
Jets at Bears: 3 Props to Play
Its the Chicago Bears vs the New York Jets at Soldier Field. Here are 3 props featuring Cole Kmet, Luther Burden, and Braelon Allen.
Lewis Ginter Botanical Garden stops paying health benefits for employees on strike
The Lewis Ginter Botanical Garden has stopped paying health benefits for all employees who went on strike over what they say are unfair labor practices.
Jackie tribute video celebrates bald eagle's wonderous life
'Deeply loved and forever missed.'