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What Doctors Want You to Know About Cannabis and Health

The government recently loosened medical marijuana rules. Experts separate fact from fiction about the drug’s safety and benefits.

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May 4 • 5:01 AM EDT • Health • nytimes.com
Caring for mental health together

In a church that proclaims God’s care for people’s bodies, minds and spirits, tending to mental health is not separate from faith.

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May 4 • 4:00 AM EDT • Health • livinglutheran.org
Global Health & WASH: May 2026 Funding Opportunities (14 new opportunities!)

The May update for Global Health & WASH brings new calls that cluster around three distinct shifts: LMIC research leadership moving from funder encouragement into a hard eligibility constraint, pharmaceutical and corporate-linked funders running structurally independent education and use-inspired research portfolios at substantial scale, and AI adoption shifting decisively from speculative tool to operational capability across health and WASH systems alike. In LMIC Research Leadership as Eligibility, Not Encouragement, Wellcome anchors the dominant signal of the month with three separate major calls that all require or strongly center LMIC leadership in their basic eligibility architecture. Wellcome’s ESIC Hubs (£1.5-£1.9M per hub over 3-5 years) explicitly requires an LMIC-based lead applicant, treating Global South leadership as a design constraint rather than a participation goal. Wellcome’s Infectious Disease Clinical Trial Development Award funds transdisciplinary teams whose lead must be a mid-career or established researcher based at an organization in Africa, South Asia, or Southeast Asia. Wellcome’s larger Infectious Disease Clinical Trial Award (£1M-£8M for optimizing licensed interventions) requires the administering organization to be in eligible LMIC regions and at least 50% of applicants based there. Around Wellcome, the same pattern shows up at smaller scale and across funders: CHINNOVA channels $1M into West and Central African research institutions for climate-health work; IBRO’s Neuroscience Training Grants explicitly tier ceilings by region of residence with Africa receiving the highest amount ($5,000); IHME’s GBD Emerging Researcher Award reserves at least one of its two annual awards for an LMIC researcher; Sidaction’s HIV Cure call funds research teams across France, the Netherlands, and eligible African countries with a minimum two-country collaboration requirement. Taken together, these calls signal a meaningful shift in how research equity is being operationalized — not as encouragement language at the bottom of a call, but as a structural feature of who can lead, where the work must be administered, and what proportion of the team must be regionally rooted. In Pharma-Funded Independent Medical Education and Use-Inspired Research, the lineup this month is unusually deep. Pfizer alone runs four parallel calls under independent education and quality improvement frameworks: a Migraine and Women’s Health RFP (200K x 2-year, $500K pool), Migraine IME ($200K, $1M pool), JAK Inhibitor evidence-based education ($100K), and Maternal Vaccination HCP Education in Saudi Arabia ($75K), plus a separate Pediatric Pneumococcal Surveillance research call in Saudi Arabia ($400K per project). Novo Nordisk Foundation runs four parallel calls of its own at substantial scale: Infectious Diseases Catalyst Grants (DKK 60M pool, up to DKK 7M collaborative), Non-Diabetic Endocrinology Collaborative Grants (DKK 53M pool, DKK 5-10M per project), Pioneer Innovator Grant Health (DKK 1.1M), and Distinguished Innovator Grant Health (DKK 6.8M). LEO Foundation deploys DKK 2-4M per project for dermatology research excellence. Pfizer’s framing across calls deliberately separates the funding from product promotion, emphasizing measurable practice-relevant change and structural distance between scientific outputs and commercial activity. Novo Nordisk’s “use-inspired” hard filter pushes researchers toward a credible translation pathway from mechanism to deployable tool. The pattern: industry-aligned funders are running structurally independent portfolios at meaningful $ that fund implementation evidence, not promotion. In AI as Operational Capability, Not Speculation, several calls this month explicitly treat AI adoption as a near-term operational question with real evidence and governance requirements, rather than a speculative trend to be watched. Wellcome’s ESIC Hubs frames AI as “the accelerator” for evidence synthesis, asking hubs to translate technical innovation into adoption-ready workflows that can match real-world policy timelines. UNICEF Venture Fund’s new Climate Tech for Children’s Health call funds for-profit startups deploying AI, machine learning, and blockchain in low-resource environments, with a strict requirement that solutions must already have a working prototype with promising pilot results. The Water Research Foundation has launched two simultaneous AI calls treating reproducibility, cybersecurity guardrails, and human-in-the-loop deployments as core design constraints rather than nice-to-haves: one on GenAI and Agentic AI in water utilities ($200K), one on alternatives to water shutoffs that explicitly screens for implementation economics evidence. Nordic Innovation’s quantum technology call (NOK 4.5M) extends the same logic into life science and healthcare, demanding consortium-stage projects mature enough to test with real users. TEF-Health offers €300K in subsidized testing infrastructure for European healthcare AI and robotics SMEs. The pattern: funders are converting AI pilots into playbooks, requiring transfer evidence and risk controls before AI can move from experimentation to sector-wide operational practice. For LMIC-based researchers in infectious disease or evidence synthesis, the three Wellcome calls together represent the deepest concentration of LMIC-led research capital in recent memory — pair the Infectious Disease Clinical Trial Development Award (£200K, deadline May 19) as a strategic pipeline feeder into the larger Infectious Disease Clinical Trial Award (£1-£8M, deadline June 2), since the development award functions explicitly as a track into the larger trial scheme. For Nordic researchers, the four Novo Nordisk Foundation calls plus LEO Foundation and Nordic Innovation Quantum represent ~$30M in regional research capital this cycle, all with deadlines clustered in May-August. For WASH practitioners, the three Water Research Foundation calls together (each up to $200K) are a cluster worth reading across — one on AI deployment, one on shutoff alternatives, one rewarding applied innovation — and the strongest applicants will articulate how their work bridges utility operations to policy-relevant evidence. For US-based clinical researchers and educators, the four Pfizer calls plus the APF Portfolio’s 80+ programs form an unusually accessible recurring pipeline; APF’s prohibition on indirect costs is a meaningful structural feature for early-career applicants whose institutions might otherwise absorb significant overhead. Snapshot of New Opportunities Total Estimated Funding Pool: $100 Million+ USD The grants are organized into three categories: Open Calls: Current grant and opportunities with a deadline. Grants are listed by closing date. 39 open opportunities- 14 new! Rolling Applications: current grant and opportunities with rolling applications (but it’s still best to submit as early as possible). 14 rolling opportunities- 1 new opportunity! Long term planning: Grants that have closed their current rounds, but are expected to open new windows. 4 long term opportunities! A quick tip for returning readers: if you want to jump straight to the newest additions, use CTRL F to search for “New!” and navigate quickly to the latest funding opportunities This post is for paid subscribers. This helps support the time and effort it takes to curate and organize these opportunities. Subscribe To keep this accessible to everyone who needs it, we’re happy to offer pay what you can rates. You can find more details here. Open Calls: Migraine Competitive Grant Program: Migraine and Women’s Health (Quality Improvement and/or Research RFP), Pfizer.*Closing soon!* Pfizer, in collaboration with the American Headache Society, is seeking independent quality improvement and research projects that close persistent gaps in migraine care for women across the United States. The funding logic centers on measurable, practice-relevant change: proposals should generate actionable evidence, tools, or system improvements that can be shared and used widely, not just within a single site. Priority areas span menstrual migraine and screening in women’s health settings, the role of hormonal fluctuations across the lifespan, sex-specific risk factors, comorbidities and quality-of-life burden, and disparities in outcomes by race, ethnicity, and socioeconomic status. The call is structured as a two-step competitive process with an initial Letter of Intent, with the strongest concepts expected to translate scientific insight into implementable improvements in diagnosis, management, and equity. Geographies: United States. Who can apply: U.S.-based organizations (not individuals), including professional schools, healthcare institutions, professional organizations, and other entities focused on healthcare improvement. Funding amount: Up to USD $200,000 total over 2 years; total pool USD $500,000. Targeted Sectors / SDGs: Health; Focus areas: migraine, women’s health, quality improvement, clinical research, menstrual migraine, health disparities. Deadline: LOI: May 5, 2026; Full proposal (by invitation): August 28, 2026. Learn more and apply here. This RFP rewards “shareable impact”: the most competitive submissions will pair rigorous methods with a clear plan for system uptake and dissemination beyond the originating institution. ReSSARC: Strengthening the Health Sector and Food Security in the Central African Republic (AID 013381/01/0) Call for Proposals, Italian Agency for Development Cooperation (AICS). *Closing soon!* AICS is seeking a limited set of high-capacity humanitarian partners to deliver an integrated package that stabilizes essential health services while reducing acute malnutrition and strengthening food security resilience in priority areas of the Central African Republic. The funder’s logic is explicitly nexus-based: proposals should meet urgent, life-saving needs while reinforcing local systems, coordination mechanisms, and community-level capacity so results persist beyond the emergency window. AICS emphasizes inclusion and protection outcomes, expecting gender-sensitive design and explicit measures for groups facing compounded vulnerability, including women, children under five, internally displaced people, and people with disabilities. The call also signals a localization pathway, encouraging stronger collaboration with national NGOs and balanced partnerships, alongside clear coordination with existing cluster and humanitarian actors to minimize duplication and improve coverage. Geographies: Central African Republic (Bangui, Ombella-Mpoko, Ouham, Ouham-Pende, Lim-Pende, Lobaye). Who can apply: Non-profit organizations registered with AICS, plus eligible non-profits without an office in Italy that have a pre-existing collaboration agreement with an AICS-listed organization. Funding amount: Total pool EUR €1,800,000; max EUR €800,000 (single applicant) or EUR €1,000,000 (ATS). Targeted Sectors / SDGs: Health; Focus areas: malnutrition prevention and treatment, maternal and child health, community health services, food security and resilience, localization partnerships Deadline: May 5, 2026. Learn more and apply here. This call is structured to reward partners who can link frontline service delivery to system durability and localization, not just short-term coverage gains. Contracts for Innovation in drug and alcohol addiction healthcare, Innovate UK. *Closing soon!* Innovate UK, on behalf of the Office for Life Sciences Addiction Healthcare Goals program, is procuring R&D to accelerate innovations that can improve treatment outcomes, strengthen recovery, and reduce harm and deaths linked to drug and alcohol addiction. The competition is positioned as a market-facing readiness push: selected projects are expected to advance solutions toward later-stage validation, generate evidence of user acceptability and UK market fit, and map credible routes through regulatory and certification requirements. Innovate UK signals a preference for innovations that can be field-tested in relevant UK settings and progressed to TRL 6 or 7, with practical plans for commercialization after contract completion. This structure favors applicants that can execute most work in-house, co-develop with service providers and people with lived experience, and translate technical progress into deployable tools for addiction healthcare delivery. Geographies: United Kingdom. Who can apply: Single organizations of any size (including EU, EEA, or international) leading delivery, with most work and key deliverables carried out in the UK; subcontractors for specialist skills only. Funding amount: GBP £200,000–1.5 million per project (inclusive of VAT); Total pool: GBP £20 million (across two strands). Targeted Sectors / SDGs: Health; Focus areas: Mental Health, Health Systems Strengthening, Research & Development, Technology Access. Deadline: May 6, 2026 (11:00am). Learn more and apply here. This call uses procurement to pull near-market addiction innovations toward operational proof and adoption pathways in UK services.

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May 4 • 3:59 AM EDT • Health • impactfunding.substack.com
Is Tencent Music (TME) Offering Value After Recent Share Price Weakness?

If you are wondering whether Tencent Music Entertainment Group at around US$9.10 is attractively priced or not, it helps to separate the story from the numbers. The stock's journey has been uneven, with a 2.6% decline over the last 7 days, a 0.8% decline over the last 30 days, a 49.0% decline year to date, a 34.8% decline over the last year, a 30.4% gain over 3 years and a 40.7% decline over 5 years. Recent coverage has focused on how Tencent Music Entertainment Group fits into the broader...

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May 3 • 12:22 PM EDT • Entertainment • simplywall.st
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Trump signs Homeland Security funding bill, ending record shutdown

DHS has been without routine funds since Feb. 14, causing hardship for workers, though much of Trump’s immigration agenda that is central to the dispute is being funded separately.

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Apr 30 • 6:23 PM EDT • Politics • pbs.org
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This AI knew the answers but didn’t understand the questions

For decades, psychologists have debated whether the human mind can be explained by one unified theory or must be broken into separate parts like memory and attention. A recent AI model called Centaur seemed to offer a breakthrough, claiming it could mimic human thinking across 160 different cognitive tasks. But new research is challenging that bold claim, suggesting the model isn’t truly “thinking” at all—it’s just memorizing patterns.

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Apr 29 • 8:00 PM EDT • Science • sciencedaily.com
A photon was teleported across 270 meters in stunning quantum breakthrough

Scientists have pulled off a first: teleporting a photon’s state between two separate quantum dots. This was done over a 270-meter open-air link, proving quantum information can travel between independent devices. The achievement marks a key step toward building quantum networks for ultra-secure communication. It also sets the stage for more advanced systems like quantum relays.

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Apr 29 • 8:00 PM EDT • Science • sciencedaily.com
Pa. House passes bill allowing PIAA to split public, private playoffs

The state House advanced legislation Wednesday that would allow the PIAA to separate public and private schools into different postseason playoff systems.

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Apr 29 • 7:06 PM EDT • Sports • lancasteronline.com
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PayPal to separate Venmo business, CNBC reports

PayPal's ​new CEO ‌is making ​Venmo ​a separate ⁠business ​as ​part of a ​broader ​reorganization, according ‌to ⁠a report by ​CNBC ​on ⁠Wednesday.

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Apr 29 • 2:31 PM EDT • Business • reuters.com
PayPal to separate Venmo business, CNBC reports

PayPal's ‌new ‌CEO ​is making Venmo a ‌separate ⁠business as ⁠part ​of ​a ​broader ‌reorganization, according to a ‌report ​by ​CNBC ​on ‌Wednesday.

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Apr 29 • 2:31 PM EDT • Business • finance.yahoo.com
Key Business Trends for US Contractors in 2026: Navigating Uncertainty in This Year and Beyond

Contractors are under pressure from every direction. Softening demand, rising competition, workforce shortages, and policy uncertainty are all hitting at once. Our latest SmartMarket Brief with CMiC documents how 262 US contractors are responding, and what separates those holding their ground from those falling behind.

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Apr 29 • 12:59 PM EDT • Business • construction.com
What Separates Porsche's GTS Models From The 'Real' GT Cars?

Porsche's naming scheme can get confusing for the uninitiated. Here's what seperates a true GT Porsche from the GTS models.

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Apr 25 • 11:25 PM EDT • Technology • jalopnik.com
Final Fantasy XIV Is Coming to Nintendo Switch 2 in August With a Separate Subscription

Square Enix has announced plans to bring Final Fantasy XIV to Nintendo Switch 2 this August – but there is a catch.

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Apr 24 • 5:19 PM EDT • Technology • ign.com
It's Happening: Final Fantasy XIV Is Coming To Switch 2 This August

Players will require a separate subscription from other platforms

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Apr 24 • 3:45 PM EDT • Technology • nintendolife.com
Final Fantasy 14 coming to Nintendo Switch 2

Square Enix is bringing Final Fantasy 14 to Nintendo Switch 2, Square Enix just announced. The game will be available this August. A short early access period of about a month is planned. The cost during this time will be entirely free. The Switch 2 version will require a separate subscription from other versions, following discussions with Nintendo. However, a...

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Apr 24 • 3:16 PM EDT • Technology • nintendoeverything.com
Popular weight loss drug linked to key benefits for patients undergoing TAVR, PCI

Two separate studies explored the value of treating heart patients with tirzepatide.

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Apr 24 • 2:09 PM EDT • Business • cardiovascularbusiness.com
New fee tied to UW Health’s 1 S. Park clinic change raises patient concerns

That shift means visits there will include a facility fee, an additional charge separate from a provider’s bill.

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Apr 23 • 11:32 PM EDT • Health • wmtv15news.com
‘Cold feet’: Deal to buy historic Idaho 55 business called off

A deal to sell Cougar Mountain Lodge fell apart on Wednesday night amid the buyers’ concerns about plans to convert the property into an event venue. Treasured antiques that have decorated the historic lodge in Smiths Ferry were set to be sold this Saturday, April 25, as part of a separate sale at the property, but that, […]

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Apr 23 • 5:23 PM EDT • Business • valleylookout.com
The intersection of music in sports: behind the curtain

Music and sports are great separately, but when placed together, they create an atmosphere like no other. Correspondent Molly McCleary examines how music in sports, like gymnastics and softball, is essential for both the players and fans.

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Apr 23 • 12:00 PM EDT • Sports • technicianonline.com
Stephen and Ayesha Curry talk about the one habit that separates good business leaders from great ones

The Currys, co-founders of Plezi Hydration, discuss leading with purpose.

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Apr 23 • 8:24 AM EDT • Business • fortune.com
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Thunder guard Jalen Williams leaves Game 2 win over Suns with apparent hamstring injury

Jalen Williams missed extended time in the regular season with a separate hamstring injury, too.

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Apr 23 • 12:22 AM EDT • Sports • sports.yahoo.com
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Unique door helps kids learn science and engineering

The so-called “STEM Door” at McAuliffe Elementary School in the Cimarron Hills area does more than separate the library from the STEM Lab. Educators described it as a way to help students understand a range of scientific concepts.

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Apr 22 • 2:20 PM EDT • Science • kktv.com
DeFi Technologies' Asset Management Business, Valour, Secures US$11 Million in Institutional Investment into Hedera ETPs, Including US$10 Million on Börse Frankfurt and US$1 Million on Sweden's Spotlight

Two separate institutional transactions, based on execution value at the time of purchase and originated through DeFi Technologies' Abu Dhabi symposium,...

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Apr 22 • 7:30 AM EDT • Business • prnewswire.com
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Indigenous health can’t be separated from environmental health, leaders tell UN

At Permanent Forum, leaders connect climate change, mining, and deforestation to mounting health crisis and demand coordinated approach to land rights.

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Apr 22 • 4:00 AM EDT • Health • grist.org
Stop Paying for a VPN: Firefox Just Built One Right Into Your Browser

Mozilla's built-in VPN offers an extra layer of privacy for your browser traffic without requiring a separate subscription.

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Apr 21 • 12:01 PM EDT • Technology • cnet.com
🚨 Line-ups ready: Mallorca and Valencia open the matchday

RCD Mallorca and Valencia CF kick off LaLiga Matchday 33 this Tuesday in a dramatic clash in the battle for survival. Separated by just one point, 14th and 15th in the table face off in one of the fir...

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Apr 21 • 11:52 AM EDT • Sports • sports.yahoo.com
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🚨 Confirmed line-ups: Athletic and Osasuna must win

San Mamés opens its doors this Tuesday, April 21 (7:00 PM) for a highly even clash on Matchday 33 of LaLiga EA Sports. Athletic Club and CA Osasuna face off separated by just one point in the standin...

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Apr 21 • 11:52 AM EDT • Sports • sports.yahoo.com
Clackamas County commission race 2026: 2 ousted members challenge 15-year incumbent

Jim Bernard and Mark Shull, both defeated in past elections, are mounting separate bids to unseat Paul Savas.

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Apr 21 • 8:00 AM EDT • Politics • oregonlive.com
Battle over Ingles heats up as April 30 meeting looms

Activist investor Summer Road is continuing its fight to win a board seat at Black Mountain-based Ingles Markets, stressing its view that the company should split off its real estate into a separate business.

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Apr 20 • 10:51 AM EDT • Business • businessnc.com
Skokie discusses hiking, expanding entertainment tax in early budget review

As Skokie staff and trustees meet this month to review their budget for fiscal year 2027, officials have recommended raising the local entertainment tax to fund a new ambulance and improvements to the village’s development services. The proposed tax hike, which trustees would have to approve by an ordinance separate from the budget, would raise […]

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Apr 20 • 4:07 AM EDT • Entertainment • therecordnorthshore.org
Scientists stunned as bacteria rewire DNA machinery to shape cells

Cyanobacteria—ancient microbes that oxygenated Earth and made complex life possible—are still revealing surprises billions of years later. Scientists have now discovered that a molecular system once used to separate DNA has been repurposed into something entirely different: a structure that shapes the cell itself.

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Apr 19 • 8:00 PM EDT • Science • sciencedaily.com
Rosalind Franklin, chemist: “Science and everyday life cannot and should not be separated”

A pioneering DNA scientist reflects on science, faith and purpose, offering a grounded view of how discovery and everyday life intertwine

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Apr 18 • 1:04 PM EDT • Science • en.as.com
Despite Mize's Brilliance, Detroit Loses A Pitching Duel In Fenway

That was one of those ball games that separates the diehards from the casual fans. I’m sure that there will be people who look at the final score and think that that game was “boring“, but for me, that’s about as entertaining as they come. It’s another night in which the Tigers played a low-scoring game with two starting pitchers who were featuring their best stuff.

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Apr 17 • 10:35 PM EDT • Sports • sports.yahoo.com
Sue Bird, Megan Rapinoe announce they have separated after 10 years
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Apr 17 • 3:43 PM EDT • Sports • sports.yahoo.com
UNC Hussman offers new sports play-by-play class | UNC Hussman School of Journalism and Media

This story, written by UNC Hussman alumna Caroline Daly ’24, was originally published on unc.edu. The UNC Hussman School of Journalism and Media has a new, hands-on class available for students interested in sports careers. Students in “MEJO 390: Sports Commentary and Play-By-Play” can call live radio broadcasts for Carolina sporting events, streamed live on the Go Heels website. This spring, 11 students are calling mostly softball games to gain experience and learn the preparation needed for a successful broadcast. The class is capped at a small number to provide consistent, individual feedback. Matt Krause, the radio voice of Carolina women’s basketball, teaches the class to help students sharpen their skills, using his experience with the Tar Heels and calling games for ACC Network and ACC Network Extra. “There is no substitute for live reps, and that is the only way you get better. The classroom component teaches you how to get better, but going about that requires sitting in that chair, making mistakes and being able to know your broadcast is going somewhere,” Krause said. “These students are doing real live games, and they will have tape where if they want to pursue this. They will have ready-made demos to send for jobs. Being able to utilize all the resources of UNC, GoHeels Productions and the Carolina Athletics brand and create these opportunities for students is really impactful.” In the class, students learn fundamentals like how to announce starting lineups for different sports and how to conduct research before games. Krause has led the class in mock preparation exercises, looking at game charts with information about the different teams and players that they can refer to at pivotal moments during the game. Krause and the students then critique each other, listening to clips from the past week to find ways to improve. It’s a rare class without a slew of quizzes or assignments. Their main tasks are calling games and making a portfolio or demo reel of their best calls at the end of the semester, all with the goal of being ready to step into similar roles after graduation. Laible live streams her coverage on the GoHeels website. Calling a live game while broadcasting her coverage allows her to get hands on experience. (Jon Gardiner/UNC-Chapel Hill) Junior Anna Laible ’27 wished for a class just like this. Her first year at Carolina, she interned with the Coastal Plain League, where she was introduced to play-by-play for baseball. “I enjoy the challenge and uncertainty of each game being different because each sport looks a little different,” said Laible. “Each game is different — not just with teams but what could happen with certain records being broken or random trends. That’s what I enjoy most.” She wanted more opportunities for reps during college to prepare for a career after Carolina, so she pitched an idea for the class to Livis Freeman ’99, distinguished associate professor of sports communication. Laible and Freeman reached out to GoHeels Productions for a partnership and then connected with Krause. “This is how at UNC Hussman we separate ourselves: Our students go into the field ready,” said Freeman. “The biggest compliment we get it is when our students start their careers, they don’t need any hand-holding.” Laible calls a Carolina softball game at Kessing Stadium – after pitching the idea to Hussman faculty. Her interest in sports commentary allowed her to apply her interest as she attends Carolina. (Jon Gardiner/UNC-Chapel Hill) Laible is now a student in the class, which has helped her strengthen her skills and deepen her passion for the field. The goal is to expand to other sports like soccer, lacrosse and field hockey. “The hands-on experience I’ve gotten here is invaluable. I’ve loved the classes and professors because they’ve taught me a lot, but it’s also the things outside of class, too, that have helped me grow,” said Laible. “Since being at UNC, I’ve grown a lot in the versatility, from doing writing to production and commentating. UNC Hussman and Carolina have given me the ability to be strong and well rounded.”

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Apr 16 • 9:07 AM EDT • Sports • hussman.unc.edu
What Rochester's small business owners miss by separating strategy, wealth

Commentary: Nicole Newman highlights how small business owners in Rochester often separate business strategy from wealth planning, limiting long-term financial flexibility.

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Apr 16 • 7:00 AM EDT • Business • rbj.net
Public hearing set for Tuesday on trans ballot initiative

The measure requires schools to designate all sports teams as male, female or co-ed. It also requires public schools to maintain separate restrooms, locker rooms and shower rooms for girls and boys.

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Apr 13 • 11:56 AM EDT • Politics • spectrumlocalnews.com
“AI polls” are fake polls

A few weeks after Donald Trump’s second presidential win, I took the train up from London (where I was living at the time) to Oxford to attend a conference on polls and forecasts of the 2024 election. Most of the attendees were pollsters or academics, but I also watched presentations from Aaru and Electric Twin, two companies that do what is interchangeably called synthetic sampling, silicon sampling, or synthetic audiences. Stripped of startup jargon, that means they use large language models (LLMs) to simulate responses to public opinion polls by having AI agents take on the role of survey respondents. I had already heard of Aaru thanks to some articles with eye-catching headlines like “No people, no problem: AI chatbots predict elections better than humans” in the months leading up to Election Day. The founders were making some big, some might even say far-fetched claims, such as: “within two years, we will simulate the entire globe — from the way crops are grown in Ukraine to how that impacts production of oil in Iraq, trade through the strait of Malacca, and elections for the mayor of Baltimore.” When Semafor asked Aaru’s cofounders — Cameron Fink and Ned Koh — about my boss, they said “we respect all those who came before us.” Nate (as he so often does) shared his thoughts on Twitter: Fink and Koh were relatively good-natured about this back-and-forth when we spoke at Oxford. They even offered to mail me one of the t-shirts featuring Nate’s quote they apparently had made. I never took them up on the offer, which I now somewhat regret. These synthetic sampling companies fell off my radar for a while, but they do still exist. In fact, Aaru recently received a $1 billion valuation. Is what they’re doing anywhere close to the most important frontier in AI development? Not by a longshot, especially when Anthropic just developed a model so adept at exploiting software vulnerabilities that it’s only being released to 40 companies. Still, silicon sampling is increasingly finding its way into public polling. Axios reported in March that “a majority of people trust their own doctors and nurses” based on findings from Aaru — without mentioning that the “people” in that sentence were actually LLMs. Around the same time, the Public Sentiment Institute “boosted” their online sample of 373 real survey respondents with 114 AI agents.1 (Spoiler alert: even the co-founder of Electric Twin doesn’t think that’s a particularly defensible approach.) Polling companies like Qualtrics and Ipsos are also developing synthetic data panels. So, what should we make of these … “polls”? Let’s get one thing out of the way: whatever they are, they’re not polls in the way that term is usually defined. Subscribe You can’t replace polls with AI On one hand, using LLMs to essentially make up fake survey respondents sort of sounds like the dumbest idea ever, one that will at best imperfectly replicate real polls while introducing all sorts of biases. On the other hand, with LLMs improving at a remarkable, perhaps even alarming rate, maybe that means I’m a dinosaur at the ripe old age of 24 because I still want to rely on polls that talk to actual people. I’m not going to argue that synthetic samples are completely useless. In fact, as I’ll return to later, there is evidence that some techniques can replicate topline survey results quickly and cheaply. But the marketing from certain companies can be slightly optimistic. “No traditional poll will exist by the time the next general election occurs,” said Fink in 2024. We’re just 206 days away from the midterms, and based on the fact that I still have to collect a bunch of polls every day, I’d say he should have run that prediction by a sample of AI agents before the interview.2 To see why synthetic samples can’t replace polls, here’s a quick primer on how they work. The simplest version of these models involves taking a LLM (like ChatGPT or Claude), giving it a demographic profile (e.g., a white, college-educated woman who lives in Utah and makes $70k a year), and then asking it to respond to a survey question. You repeat that process a few thousand times using different demographic profiles and end up with a sample of synthetic survey responses. The actual models used by private companies are more sophisticated than this, usually because they incorporate more hypothesized demographic characteristics for each agent and provide them with extra information. Aaru, for example, feeds agents a diet of news and information they’d be likely to consume, while Electric Twin incorporates their customers’ proprietary data about the audience they’re trying to replicate. The way Ben Warner, the co-founder of Electric Twin, explained it to me was “we have a large amount of data on […] for instance, 5,000 people. Can we make an accurate prediction of how they would respond to another question?” Still, it should be obvious why synthetic samples can’t replace polls. Polling is fundamentally a data collection process. We might use surveys to make predictions by feeding them into election forecasts, but the main purpose of a poll isn’t prediction, it’s gathering new data about what people think and how they feel. Silicon sampling, on the other hand, produces no new data. It’s simply a model: you input LLM training data, demographic prompts, and a bunch of other information, and it spits out a prediction for what a poll would say. We love models here, but models aren’t polls. That difference is an important philosophical sticking point for most pollsters I talk to. “I think politics should stay away from [synthetic sampling], because we’re trying to […] represent the voice of the people,” said Natalie Jackson, a vice president at GQR Insights. Democratic pollster John Hagner told me: “I think I’m just incredibly skeptical of this idea. I don’t think it’s research. At that point, you’re asking the machine to tell you what you already believe.” Hagner has seen some presentations of early synthetic sampling experiments, but so far, “if it’s being used in a campaign, people are keeping it incredibly quiet.”3 But Eli, I hear you saying, aren’t polls themselves increasingly governed by modeling decisions? Indeed they are: pollsters’ choices on which sampling method to use, how to define their likely voter models, and how to weight their samples can and do lead to dramatic differences in the results they publish. Aaru even referenced these limitations in the methodology statement included with that maternal mortality “poll” — although I’m using the term “methodology statement” loosely here, because it doesn’t really explain how the model works at all. We can ignore the (frankly preposterous) implication that synthetic sampling isn’t subject to a separate set of biases. The important point is that there’s still a meaningful difference between using weighting and other statistical techniques on actual polling data and using a model to predict what a poll would say. The latter is far closer to election forecasts or techniques like MRP — potentially useful models, but not a replacement for polls.4 To be fair, other synthetic sampling companies are perfectly happy with the distinction between polls and models. Warner compared polling and synthetic sampling to different tools in a toolbox. “The mistake I think we make is we think that these new tools should either work in exactly the same way or somehow replace these old tools,” he said. “Rather than thinking of it as, okay, so we’ve always had the hammer, we’ve always had the screwdriver, now we’ve got a saw. But don’t use a saw to try [to] do the job of a hammer.” A quick comment from Nate Eli didn’t ask me for a comment — rather rude of him, don’t you think? But since I’m editing this story, I figured I’d add a few quick thoughts rather than putting words in his mouth. Beyond the frequently misleading marketing, what bothers me about the AI “poll” hype is that as AI tools make statistical inference cheaper and/or better (note that these are not synonyms) that actually increases the comparative value of collecting original data. You might be able to train a model to make a reasonable estimate of what some hard-to-reach poll respondent would say — say, a young Black man who voted for Trump. (Such a person checks a number of boxes for a voter who is usually hard to reach in surveys.) Indeed, this is closely related to what models like the Silver Bulletin forecast already do. They essentially smooth out the kinks in noisy survey data by making inferences based on past voting patterns or national polls or surveys of other states. But you don’t actually know what these voters think unless you’re reaching them directly. If there’s a shift in opinion among this subgroup, you’re not going to detect it. So if I were running a campaign, I’d invest more in going the extra mile to find a representative sample of those voters. And then I’d hire some smart quants — or Claude? — to figure out the implications for campaign strategy based on proprietary data that my competitors didn’t have access to. -Nate Silver Are these models any good? If synthetic surveys are just a new type of model, the next obvious question is whether the models are at least accurate. The answer very much depends on who you ask. On one end of the spectrum, you have the maximalist argument that synthetic sampling is more accurate than actual polls. “It’s an incredibly challenging problem to go to someone and say ‘hey, we’re going to be more accurate at predicting human behavior than you, even when you talk to your customers directly’,” Koh recently told CNBC. In his view, synthetic sampling isn’t a saw to polling’s hammer, it’s “magic.” There’s certainly evidence that synthetic samples can replicate certain survey toplines. But if Aaru does have any examples of their approach outperforming the polls, they’re keeping those to themselves.5 Aaru’s 2024 election model, for example, had Kamala Harris leading in Michigan, Nevada, Pennsylvania, and Wisconsin on November 4th. And although they’ve since taken down their forecast page, they gave Harris a 50.5 percent chance of winning the race on November 2nd.6 After the election, Fink told Semafor he was happy enough with those results because they were “within margin of error,” a term that is completely meaningless when applied to a “sample” of AI agents. And of course, Aaru says their models have improved since 2024, so supposedly now they’d be more accurate than the polls? Still, their stronger argument is on cost: “We are significantly faster and cheaper than traditional polling, and still more accurate,” said Fink. The first two claims are undeniably true, but the third brings us to the opposite end of the spectrum. Both Jackson and Hagner are skeptical that these models are reliable for anything beyond replicating common survey toplines. “I just […] don’t think the machines are what we want when we’re looking for nuanced views. My example on this is people in Arizona and Nevada in 2024 who voted for Trump and voted for expanding abortion in their states on ballot initiatives,” said Jackson. Hagner identified another issue. Maybe the synthetic respondents, like sycophantic LLMs, are inhuman in one important way: they’re too nice. “The reports that have come through at the meetings that I’ve been at are that the early experiments on this, they cannot get respondents to be as racist or sexist or, frankly, as negative as human respondents,” he said. Academic research mostly agrees on this point. While there are some papers that show promising results when using LLMs to replicate polling data, most show that LLMs suffer from various quirks like producing too few “don’t know” responses and can seriously overpredict the favorability of politicians like Donald Trump and Kamala Harris. They also seem to struggle with too little variation between demographic subgroups, so the difference in predicted opinion between Democrats and Republicans, for example, is too small. When I asked Warner about these studies, his response to these papers was that just because academics can’t get synthetic sampling to work doesn’t mean that the technique doesn’t work in general. “Actually, the argument is, okay, yours does not [work]. That does not mean […] for this complex set of machinery, which uses a lot of investment, a lot of time, a lot of money, you can’t get it to work.” Cards on the table, I’m somewhat sympathetic to this argument because academics aren’t exactly great at making election forecasts. Usually, the people with skin in the game are the most accurate. Warner’s argument is that the approach Electric Twin takes — which includes, for example, making multiple predictions for each synthetic respondent using different models and prompts and subsequently averaging those to get a final prediction in a sort of ensemble forecast — produces better results than the simpler academic models. Warner shared a comparison between his method and the method from a recent academic paper with me, and Electric Twin was indeed able to get more accurate replication. But even still, he acknowledged that synthetic sampling “is not a crystal ball.” “If you asked me, do I think using other data sources will be more accurate than asking somebody who they will vote for, I would probably say no. But if you asked me ‘would your system be useful for our turnout modeling today?’ I would say yes.” For better or worse, it looks like the method is already getting more popular in the market research world. Most of the clients Aaru touts these days are businesses like EY and McDonald’s. And AI will probably begin to pop up in other parts of the political polling process. Pollsters are already using it to code open-ended survey responses, and some firms, like YouGov, are testing using LLMs to ask survey respondents questions. More worryingly, one danger to actual polls is that AI agents can be used to infiltrate online surveys. Most online polls use various checks to prevent that from happening, but there’s conflicting evidence on how effective those filters are and how prevalent AI agents currently are in online panels. If those agents ever become impossible to detect, it might spell the end of online polling, but the solution isn’t to replace all of your respondents with ChatGPT. Silver Bulletin is a reader-supported publication. To receive new posts and support our work, consider becoming a subscriber. Subscribe 1 That particular poll obviously doesn’t meet Silver Bulletin standards for aggregation. But we exclude all Public Sentiment Institute polls from our averages because we classify them as an amateur polling firm. 2 You could argue that Fink meant the next presidential election, but (a) I’m also confident we’ll still have real polls in 2028 and (b) in that case he should have asked an LLM to define “general election.” 3 Quick caveat: that’s reporting from a Democratic pollster. It’s possible that Republicans are more willing to use AI in political campaigns. 4 Indeed, Silver Bulletin does not include “polls” produced by MRP in our forecasts or averages, and we think it’s extremely misleading when their practitioners describe them in a way that suggests original data had been collected among a large number of states or Congressional districts. 5 A recent report from Aaru and EY did show two examples of a synthetic estimate being closer than a survey to a real-world benchmark — but I’d take those findings with a grain of salt because the report reads more like an ad and didn’t involve any sort of prediction being made ahead of time. 6 For comparison, our odds for Harris on the same day were 48.2 percent.

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Apr 11 • 11:38 AM EDT • Technology • natesilver.net
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Apr 11 • 1:40 AM EDT • Sports • sports.yahoo.com
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Glyphosate: A story of science, risk, and nuance

In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe

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Mar 25 • 10:25 AM EDT • Science • yourlocalepidemiologist.substack.com
New Mexico jury says Meta harms children's mental health and safety, violating state law

The jury agreed that Meta engaged in "unconscionable" trade practices that unfairly took advantage of the vulnerabilities of and inexperience of children. Jurors found there were thousands of violations, each counting separately toward a penalty of $375 million.

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Mar 24 • 6:12 PM EDT • Health • npr.org
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We disagreed on politics. We agreed on wine. That was enough.

At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.

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Mar 23 • 10:54 PM EDT • Politics • dmwineline.substack.com
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My twins separated for the first time at 19

After doing everything together their entire lives, my twin sons separated for six weeks and hardly checked in. It was good for their relationship.

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Mar 21 • 10:42 AM EDT • Business • businessinsider.com
Unilever in talks to combine food business with McCormick, WSJ reports

Unilever is in ​talks to separate its food ‌business and combine it with spice maker McCormick in an all-stock ​deal which could come ​within weeks, the Wall Street ⁠Journal reported on Thursday, citing ​sources.

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Mar 19 • 7:28 PM EDT • Business • reuters.com
Exclusive | Unilever in Talks to Separate Food Business and Combine It With McCormick

The remaining Unilever company would focus on beauty, personal-care products and home.

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Mar 19 • 6:42 PM EDT • Business • wsj.com
Babson Taps Multigenerational Business Leaders for 2026 Commencement Addresses

CEO and Executive Chairman of Metropoulos & Co. C. Dean Metropoulos '67, MBA'68, will give the undergraduate Commencement address, with Cisneros CEO Adriana Cisneros speaking at the graduate Commencement ceremony.Wellesley, Massachusetts--(Newsfile Corp. - March 19, 2026) - Babson College will honor the achievements of more than 740 undergraduate and 540 graduate members of the Class of 2026 before thousands of family members, faculty, friends, colleagues, and peers in separate on-campus...

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Mar 19 • 12:37 PM EDT • Business • finance.yahoo.com
Trump’s face on a gold coin? His hand-picked panel will decide.

The proposal has already been rejected by members of a separate federal coin committee — and panned by former member Kareem Abdul-Jabbar.

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Mar 19 • 5:00 AM EDT • Politics • washingtonpost.com
Family Sharing in iOS 26.4 No Longer Forces Adults to Share a Payment Method

With iOS 26.4, Apple has made a small but useful change to the way that Family Sharing works. Each adult member of the family can now use their own payment method for purchases, rather than being forced to share a payment method. Apple has long required all of the members of a Family Sharing group to use a single shared payment method for app and content purchases when purchase sharing is turned on, with no option for family members to use separate payment methods.

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Mar 18 • 2:06 PM EDT • Technology • macrumors.com
Attaining Optimal Gut Health: Doctor Separates Facts From Myth

Dr. Roshini Raj, gastroenterologist at New York University Langone Medical Center, joins TODAY to talk about what’s best for your digestive and gut health. She also separates facts and fiction when it comes to lemon water detoxing your stomach, whether you can have too much fiber and more.

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Mar 17 • 9:29 AM EDT • Health • today.com
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Outside Lands act to play intimate Bay Area shows ahead of festival

Mariah the Scientist will be in San Francisco and Oakland for her “Hearts Sold Separately” tour, in support of her recent album of the same name.

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Mar 17 • 9:00 AM EDT • Entertainment • sfchronicle.com
Iran’s attacks have collapsed, and the trend is ‘overwhelmingly positive,’ analysts say. But the military side is separate from politics and markets

Iranian drone attacks on the United Arab Emirates collapsed from 332 on the second day of the war to just six on Sunday, according to the Institute for the Study of War.

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Mar 16 • 12:09 PM EDT • Politics • fortune.com
This is your brain on pleasure (even the guilty kind)

It’s likely you have at least one “guilty pleasure.” Maybe it’s romance novels. Or reality TV… Playing video games… or getting swept into obscure corners of TikTok. Neuroscientists say the pleasure response helps us survive as a species. So why do we feel embarrassed by some of the things we love the most? Even if you don't have these negative emotions, experiencing – and studying – pleasure is not as straightforward as it might seem. For a long time, neuroscientists thought the concept of "pleasure" referred to a singular system in the brain. But as research into the subject grew, scientists realized that pleasure is really a cycle of "wanting" and "liking" – each with separate neural mechanisms. Today on the show, producer Rachel Carlson explores this cycle with researchers, who weigh in on the science of pleasure. Even the kind that makes us feel guilty. Read more of Rachel’s story on guilty pleasures. Interested in more brain science? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

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Mar 16 • 3:00 AM EDT • Science • npr.org
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Strengthening One Health Field Epidemiology Capacity in the WHO South-East Asia Region

Recent public health emergencies—including the COVID-19 pandemic, recurrent zoonotic disease outbreaks, and the high level of antimicrobial resistance—have underscored the urgent need for strong, multisectoral field epidemiology capacities. This reinforces the importance of a workforce equipped with One Health field epidemiology competencies. To address this need, WHO works with the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), and the World Organisation for Animal Health (WOAH), as part of Quadripartite Alliance for One Health, to strengthen field epidemiology training programmes using a One Health approach.These efforts are aligned with WHO SEARO’s Strategic Framework for Action for Strengthening Surveillance, Risk Assessment and Field Epidemiology and the Regional Roadmap to Advance Field Epidemiology Capacities 2025–2029 emphasize workforce development, multisectoral collaboration, and enhanced preparedness for health emergencies. With funding from the Pandemic Fund, The Competency for One Health Field Epidemiology (COHFE) integration within Field Epidemiology Training Programmes (FETPs) or similar initiatives has been initiated in Bangladesh and India and is planned in Sri Lanka.BangladeshIn Bangladesh, COHFE is being adapted to strengthen the Field Epidemiology Training Programme, Bangladesh (FETP-B) Advanced programme. Initiated in July 2025 and led by the Institute of Epidemiology, Disease Control and Research (IEDCR), the process brought together stakeholders from human, animal, and environmental health sectors, academia, and laboratories.A Multisectoral Working Group (MWG) was established to guide implementation, conduct readiness assessments, and identify opportunities to institutionalize One Health collaboration. Through national multisectoral consultations and a competency prioritization workshop held in Dhaka in November 2025, stakeholders identified priority technical competencies for surveillance, outbreak investigation, data analysis, and risk assessment, alongside functional competencies related to leadership, coordination, and the laboratory–epidemiology interface. The process also surfaced systemic barriers—such as challenges in data sharing and limited joint investigations—enabling targeted recommendations. These outcomes are guiding curriculum revision, the introduction of One Health simulations and joint field exercises, and the development of a national multisectoral mentorship pool, with updated training materials expected to be implemented in the upcoming cohort.Figure 1. Competency prioritization involving multisectoral stakeholders“COHFE represents a significant step forward in operationalizing the One Health approach. The collaboration between national institutions and the Quadripartite partners is critical for building resilient systems to address complex health challenges in the region.”, Prof. (Dr) Tahmina Sirin, Director, Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh.Aligning India’s One Health Training with COHFEIn India, the National Centre for Disease Control (NCDC) has strengthened One Health workforce development through its SectorConnect initiative. WHO supported a comprehensive competency mapping and curriculum review to align the Field Epidemiology Programme in One Health (FEP-OH) with all 14 COHFE domains. The review identified strong foundations while generating actionable recommendations to strengthen One Health learning outcomes, expand joint field-based learning, and enhance competency-based assessment. These improvements are informing programme refinement and phased scale-up across additional states.Figure 2. Strengthening learning outcomes for the SectorConnect FEP OH CurriculumThrough these efforts, WHO SEARO will continue to support countries to move from separate sector-based training toward an integrated, impact-driven One Health field epidemiology workforce capable of addressing complex health threats at human-animal-environment interface.ReferencesFood and Agriculture Organization of the United Nations, World Health Organization, & World Organisation for Animal Health. (2024). Competencies for One Health field epidemiology (COHFE) framework. https://www.who.int/publications/i/item/9789240080058World Health Organization. (2023). Strategic framework for action for strengthening surveillance, risk assessment and field epidemiology for health security threats in the WHO South-East Asia Region. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290210030World Health Organization. (2024). Regional roadmap to advance field epidemiology capacities in the WHO South-East Asia Region 2025–2029. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290229544

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Mar 15 • 8:00 PM EDT • Health • who.int
The ER staffing conflict, and no facility fee for a marmot

A battle between doctors and a hospital system is an early test of a new law designed to separate business and medicine.

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Mar 9 • 11:44 AM EDT • Health • statnews.com
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I'm in a committed relationship, but we live in separate homes

My partner lives off-grid in a yurt while I rent a lakeside home. Living apart has strengthened our relationship.

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Mar 7 • 12:39 PM EST • Business • businessinsider.com
South Carolina Lt. Gov. Pamela Evette pitches business focus in GOP governor primary

Lt. Gov. Pamela Evette, met with voters in Mount Pleasant, as she works to separate herself from a crowded GOP primary field by emphasizing her business backgro

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Mar 6 • 6:45 PM EST • Business • abcnews4.com
Anthropic's Claude found 22 vulnerabilities in Firefox over two weeks

In a recent security partnership with Mozilla, Anthropic found 22 separate vulnerabilities in Firefox — fourteen of them classified as "high-severity."

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Mar 6 • 2:00 PM EST • Technology • techcrunch.com
Apple Does Not Include a Charger With All New MacBooks in UK and EU

None of the new MacBook Neo, MacBook Air, or MacBook Pro models unveiled this week come with a charger in the UK and EU countries, such as Germany, France, Italy, and Spain. This change began with the base 14-inch MacBook Pro last year. If you need a power adapter, you must purchase one separately during checkout or later. In all other countries, Apple includes a charger in the box with these Macs, at no additional cost.

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Mar 4 • 7:55 PM EST • Technology • macrumors.com
Scientists discover the protein that malaria parasites can’t live without

Scientists have uncovered a crucial weakness in the malaria parasite that could open the door to new treatments. Researchers identified a protein called Aurora-related kinase 1 (ARK1) that acts like a traffic controller during the parasite’s unusual cell division process, ensuring its genetic material is properly separated as it multiplies. When scientists switched off ARK1 in laboratory experiments, the parasite could no longer replicate correctly and failed to complete its life cycle in both humans and mosquitoes—effectively halting its ability to spread.

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Mar 4 • 7:00 PM EST • Science • sciencedaily.com
Google Pixel 10a review: Better than you’ve heard

Trying to review the Pixel 10a feels like trying to bridge two completely separate narratives into one cohesive story. The...

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Mar 4 • 12:00 PM EST • Technology • 9to5google.com
YouTube TV is Adding New Channels to Its Entertainment & Family Packages

YouTube TV has introduced Adult Swim as a new standalone channel within its Entertainment package, delivering a targeted boost for subscribers seeking mature animated and comedic programming. The update separates this content from related family offerings, allowing the service to address distinct viewer preferences more effectively. Cartoon Network, by contrast, joins the Family package exclusively, […]

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Mar 3 • 1:47 PM EST • Entertainment • cordcuttersnews.com
For every known vertebrate species, two more may be hiding in plain sight

Earth’s vertebrate diversity may be far richer than anyone realized. A sweeping analysis of more than 300 studies suggests that for every known fish, bird, reptile, amphibian, or mammal species, there are about two nearly identical “cryptic” species hiding in plain sight—genetically distinct but visually almost impossible to tell apart. Thanks to advances in DNA sequencing, scientists are uncovering these long-separated lineages, some evolving independently for over a million years.

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Mar 2 • 7:00 PM EST • Science • sciencedaily.com
No Business As Usual

On Feb. 28, after an anti-ICE protest hosted by the Party for Socialism and Liberation and several labor unions, a smaller, separate group of approximately 60 protesters held a “No Business as Usua…

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Mar 1 • 6:47 PM EST • Business • eugeneweekly.com
Bipartisan efforts to address housing issues move through Congress

Concerns over housing costs are getting the attention of lawmakers, as two separate proposals make their way through Congress.

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Feb 28 • 9:00 AM EST • Politics • spectrumlocalnews.com
The first animals on Earth had no skeletons and that changes everything

Sponges may be ancient, but their timeline has been murky. New research suggests the earliest sponges were soft and skeleton-free, explaining why their fossils don’t appear until much later. By analyzing hundreds of genes and modeling how skeletons evolved, scientists found that mineralized spicules arose separately in different sponge lineages. The discovery rewrites the story of how the first reef-building animals—and possibly the first animals of all—emerged.

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Feb 28 • 7:00 AM EST • Science • sciencedaily.com
First Brands nears bankruptcy settlement, tees up business unit sales

Bankrupt auto parts maker First Brands is close to a bankruptcy settlement with its creditors, seeking to wind down most of its business while teeing up separate sales for four business lines that are being funded by major customers like Ford and General Motors .

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Feb 27 • 11:47 AM EST • Business • reuters.com
Bethesda Is Quietly Rebuilding Fallout 76's Foundation With The Backwoods | Preview

A new structure separates solo friendly content from multiplayer public events while adding dynamic encounters to keep runs unpredictable.

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Feb 27 • 10:00 AM EST • Technology • mmorpg.com
Scientists compared dinosaurs to mammals for decades but missed this key difference

Baby dinosaurs weren’t coddled like lion cubs or elephant calves—they were more like prehistoric latchkey kids. New research suggests that young dinosaurs quickly struck out on their own, forming kid-only groups and surviving without much parental help, while their massive parents lived entirely different lives. Because juveniles and adults ate different foods, faced different predators, and moved through different parts of the landscape, they may have functioned almost like separate species within the same ecosystem.

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Feb 26 • 7:00 PM EST • Science • sciencedaily.com
A Look At Corteva (CTVA) Valuation After Earnings Miss And Planned Business Separation

Why Corteva’s restructuring plans are in focus Corteva (CTVA) is back on investors’ radar after its recent earnings report, where revenue came in below expectations and management outlined plans to separate the Seed and Crop Chemicals businesses. At the same time, UBS and JPMorgan downgraded the stock, pointing to execution risks around the breakup and a more cautious outlook. This is helping shape how the market is reassessing Corteva’s story right now. See our latest analysis for...

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Feb 26 • 2:11 AM EST • Business • finance.yahoo.com
Letters to the Editor - Primary voting, political mailers, UNT layoffs, peace, tariffs

Readers don’t like separate primary voting, call political brochures nonsense, aren’t happy about the layoffs at UNT, ask if the president truly wants peace...

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Feb 26 • 1:30 AM EST • Politics • dallasnews.com
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Buss: When 'health education' expands to sex, lines blur

The real issue isn’t whether Michigan has separated sex education from general health ed on paper — it has.

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Feb 24 • 3:05 PM EST • Health • detroitnews.com
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First lady Melania and Donald Trump bringing separate guests to SOTU in break with precedent

First lady Melania Trump will bring guests to the State of the Union address representing her foster care and responsible AI platforms while President Donald Trump has invited his own set of guests – a move that marks a break from precedent.

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Feb 24 • 10:51 AM EST • Politics • cnn.com
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Two Argonne scientists receive 2025 DOE Early Career Research Awards

Two Argonne scientists, David Kaphan and Yong Zhao, have been named to the U.S. Department of Energy’s Early Career Research Program for separate projects in catalysis and nuclear physics.

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Feb 23 • 7:00 AM EST • Science • anl.gov
Merck to create separate cancer business to offset Keytruda patent loss

Merck said on ⁠Monday it will split its human-health ​business into ​two ​divisions, separating its cancer franchise from ⁠its non-oncology ‌medicines.

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Feb 23 • 6:58 AM EST • Business • cnbc.com
Merck to create separate cancer business to offset Keytruda patent loss, WSJ reports

Drugmaker Merck is separating its human-health business into two divisions to offset pressures related to the patent loss of its top-selling drug Keytruda, the Wall Street Journal reported on Monday.

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Feb 23 • 6:22 AM EST • Business • reuters.com
Exclusive | Merck Creates Separate Cancer Business as Sales Pressure Looms

The drugmaker is splitting its pharmaceuticals unit to bolster product launches before a crucial patent loss.

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Feb 23 • 6:00 AM EST • Business • wsj.com
Colorado GOP officers set competing meetings to hold ‘no-confidence’ votes on state chair Brita Horn

Once again, members of the Colorado Republican Party’s central committee have scheduled separate, competing meetings to consider whether the state GOP’s governing body supports its chair, but this time neither meeting will be held under a bridge. State GOP Chair Brita Horn on Feb. 14 issued a formal call for an online meeting on March […]

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Feb 20 • 10:17 PM EST • Politics • coloradopolitics.com
Meta's metaverse leaves virtual reality

Meta said it's shifting focus for Horizons Worlds to be "almost exclusively mobile" and that it will separate its Quest VR platform from the virtual world.

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Feb 20 • 11:00 AM EST • Technology • techcrunch.com
MSG Sports considers splitting up New York Knicks and Rangers

The two New York-based NBA and NHL teams would be spun off by MSG Sports into separate publicly traded businesses.

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Feb 19 • 7:20 AM EST • Sports • sportspro.com
Tata's data centre business signs up OpenAI as customer

OpenAI ‌will become ‌the first customer of ​India's Tata Consultancy Services' data center business, beginning ‌with ⁠100 megawatts of capacity, the ⁠parent firm of ChatGPT ​said ​on ​Thursday. Separately, Tata ‌Group is planning to deploy ChatGPT Enterprise across the company over ‌the next ​several ​years, ​starting with ‌hundreds of thousands ​of ​employees, OpenAI added.

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Feb 18 • 10:02 PM EST • Business • finance.yahoo.com
Google Pixel 10a vs Pixel 9a: Is Google's New Phone Worth the Upgrade?

The Google Pixel 10a is strikingly similar to its predecessor, the Pixel 9a. In fact, very little separates them. I had a chance to check out the 10a early—here’s what sets it apart from the 9a.

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Feb 18 • 5:03 PM EST • Technology • pcmag.com