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Exclusive First Look: Ridley Scott Says The Dog Stars Will Surprise You
Jacob Elordi, Margaret Qualley, and Josh Brolin play desperate survivors in this adaptation of Peter Heller’s end-of-days novel.
Adopting, advancing and adapting to AI
In Penn State's Eberly College of Science, researchers are leveraging AI in a myriad of applications and instructors are finding innovative ways to incorporate AI into their classrooms. But what is artificial intelligence, and are people really talking about the same thing when they say AI?
US small businesses are adapting to higher fuel prices, supply issues
Rising fuel prices are affecting US small businesses like Wonderstate Coffee, which said it's grappling with higher costs and supply chain challenges.
Wild Animals Are Adapting to City Life in Surprising Ways, Scientists Reveal
There's a pattern to their behavior.
Studio Behind Umamusume: Pretty Derby Reportedly Facing Insolvency
The Japanese animation studio reported a $3.5 million deficit in its latest financial earnings report, following several years of reported losses
‘Lady Disdain’ world premiere rides sparkling into Overture
Madison company Forward Theater presents Lauren Gunderson’s bawdy enemies-to-lovers adaptation of “Much Ado About Nothing” through April 26.
How streaming platforms reignited the YA boom: TSITP to Heated Rivalry
Diverse storylines, coupled with the global reach of streaming platforms, have reignited an explosion of YA adaptations, and it's a race that isn’t slowing down.
The underworld invades Sutter Street Theatre
FOLSOM — "Hadestown: Teen Edition," an intriguing and beautiful folk opera, delivers a deeply resonant and defiantly hopeful theatrical experience. The full-length adaptation of Anaïs Mitchell’s "Hadestown," modified for performance
Samsung to fix Adaptive Clock glitch in One UI 8.5 update
Adaptive Clock has a glitch on One UI 8.5 devices, and Samsung is working on a fix. The problem has been acknowledged by a community moderator, who promised the addressal with the next Beta software update. It’s already a big day for Samsung users, thanks to One UI 8.5 rollouts. Whether it’s new Beta releases […]
Scientists Baffled by Bizarre “Living Fossil” From 275 Million Years Ago
Tanyka amnicola is a newly identified ancient tetrapod known from unusual twisted jawbones adapted for grinding plants. This rare herbivorous “living fossil” helps scientists better understand early evolution and ecosystems in Gondwana. In a dry riverbed in Brazil, deep within a forest near the A
Adaptive sports program visits Southern Arizona P.E. classes, wheelchairs in tow
When her class moved outside for P.E., special education teacher Tiffani Jaseph saw the excitement. After coaches and players from Adaptive Sports In Schools, or ASIS, unloaded dozens of wheelchairs at Copper View Elementary in the Sahuarita School District, they told students about racing the chairs and playing wheelchair basketball. Jaseph saw the difference in […]
Treasury Wine Estates’ Elise Spangenberg named to North Bay Business Journal’s Forty Under 40
“Being part of a newer generation of leaders allows me to challenge legacy thinking, introduce modern people practices, and help organizations adapt in ways that keep them competitive and relevant.”
Paramount Launches Book Imprint in IP Play
The new division, Paramount Global Publishing, will adapt the company's IP into books and other titles, while also developing new original stories that could find their way to the screen.
‘Project Hail Mary’ reinvigorates the science-fiction genre
The highly anticipated book-to-movie adaptation "Project Hail Mary" showcasts the star power of Ryan Gosling and collaborative nature of filmmaking.
Remigration and the New Far-Right Politics of Mass Deportation
Panelists will explore the various interpretations and adaptations of a remigration agenda to fit local political and social contexts in Europe, the UK, and the US, offering regional perspectives on this growing transnational narrative and its implications for democratic governance, civil rights, and the future of immigration policy.
Do adaptogens really work? What the science says
Adaptogens are popular plant and fungi compounds, but the science on their effectiveness and safety is still evolving.
‘Les Misérables’ and more Seattle theater highlights in April, May 2026
There's lots to see on Seattle stages in April and May, from "Les Misérables" to three new adaptations of Chekhov comedies and more.
Lewis Hamilton Introduces the Next Generation of EA SPORTS
Meet the Future of Sport: GEN / EA SPORTS Unveils New Anthem and Athlete
Aqara W200 launches with Apple’s Adaptive Temperature support
The Aqara W200 brings Matter 1.4, built-in mmWave, and Apple Adaptive Temperature. Here is a closer look at what it means for Apple Home.
ASU research looks to help Valley small businesses adapt to AI
While businesses are struggling to keep up with large companies in the Artificial Intelligence boom, local researchers are working to give them an edge.
Zhou earns CAREER Award from the National Science Foundation
Through the early-career grant, Peipei Zhou will advance the scalable, verifiable co-design of heterogeneous reconfigurable computing systems, enabling domain experts to efficiently build next-generation customized AI and data-intensive applications, such as autonomous physical systems, adaptive intelligent agents, and advanced healthcare technologies.
'They could spend 4 or 5 hours per day underwater': How humans adapted to the most challenging environments
In the book "Adaptable," evolutionary anthropologist Herman Pontzer explores human biology and development, and how people have evolved to survive everywhere on Earth.
Do adaptogens really work? What the science says
Here’s what adaptogens are, how they may improve your health and why they aren’t for everyone.
Do adaptogens really work? What the science says
Here’s what adaptogens are, how they may improve your health and why they aren’t for everyone.
State of Texas: Smokable hemp ban takes effect, businesses work to adapt
A new state rule banning the sale of intoxicating hemp flower is now in effect in Texas. Business owners say the impact is immediate.
Mass Effect TV show ordered to rewrite scripts and make them "more appealing to non-gamers"
Amazon has allegedly asked for the TV adaptation of Mass Effect to be rewritten to make it "more appealing to non-gamer…
4 New Gadgets For Your Car's Dashboard That Outshine Built-In Tech
Some solid gadget options for car dashboard tech enhancements include heads-up displays, tire pressure monitoring systems, and wireless CarPlay adapters.
Previously Unknown Human Lineage Discovered In Northern East Asia Survived And Adapted After The Ice Age Ended
The results suggest these hunter-gatherers persisted and adapted to a warming world, rather than being quickly replaced by farmers.
Starfield PS5 Pro Specs Revealed: PSSR Supported, DualSense’s Adaptive Triggers Available
Bethesda has revealed the PS5 specs for Starfield. The DualSense's Adaptive Triggers are supported, and so is PSSR on PS5 Pro.
Gemma 4 and what makes an open model succeed
Having written a lot of model release blog posts, there’s something much harder about reviewing open models when they drop relative to closed models, especially in 2026. In recent years, there were so few open models, so when Llama 3 was released most people were still doing research on Llama 2 and super happy to get an update. When Qwen 3 was released, the Llama 4 fiasco had just gone down, and a whole research community was emerging to study RL on Qwen 2.5 — it was a no brainer to upgrade. Today, when an open model releases, it’s competing with Qwen 3.5, Kimi K2.5, GLM 5, MiniMax M2.5, GPT-OSS, Arcee Large, Nemotron 3, Olmo 3, and others. The space is populated, but still feels full of hidden opportunity. The potential of open models feels like a dark matter, a potential we know is huge, but few clear recipes and examples for how to unlock it are out there. Agentic AI, OpenClaw, and everything brewing in that space is going to spur mass experimentation in open models to complement the likes of Claude and Codex, not replace them. Especially with open models, the benchmarks at release are an extremely incomplete story. In some ways this is exciting, as new open models have a much higher variance and ability to surprise, but it also points at some structural reasons that make building businesses and great AI experiences around open models harder than the closed alternatives. When a new Claude Opus or GPT drops, spending a few hours with them in my agentic workflows is genuinely a good vibe test. For open models, putting them through this test is a category error. Something else to be said about open models in the era of agents is that they get out of the debate of integration, harnesses, and tools and let us see close to the ground on what exactly is the ability of just a model. Of course, we can’t test some things like search abilities without some tool, but being able to measure exactly the pace of progress of the model alone is a welcome simplification to a systematically opaque AI space. Share The list of factors I’d use to assess a new open-weight model I’m considering investing in includes: Model performance (and size) — how this model performs on benchmarks I care about and how it compares to other models of a similar size. Country of origin — some businesses care deeply about provenance, and if a model was built in China or not. Model license — if a model needs legal approval for use, uptake will be slower at mid-sized and large companies. Tooling at release — many models release with half-broken, or at least substantially slower, implementations in popular software like vLLM, Transformers, SGLANG, etc due to pushing the envelope of architectures or tools. Model fine-tunability — how easy or hard it is to modify the given model to your use-case when you actually try and use it. The core problem is that some of these are immediately available at release, e.g. general performance, license, origin, etc. but others such as tooling take day(s) to week(s) to stabilize, and others are open research questions — with no group systematically monitoring fine-tunability. In the early era of open models, the days of Llama 2 or 3 and Qwen pre v3.5, the architectures were fairly simple and the models tended to work out of the box. Some of this was due to the extremely hard work of the Llama, Qwen, Mistral, etc. developer teams. Some is due to the new models being genuinely harder to work with. When it comes to something like Qwen 3.5 or Nemotron 3, with hybrid models (either gated delta net or mamba layers), the tooling is very rough at release. Things you would expect to “just work” often don’t. I’ve been following this area closely since we released Olmo Hybrid with a similar architecture, and Qwen 3.5 is just starting to work well in the various open-source tools that need to all play nice together for RL research. That’s 1.5 months after the release date! This is just to start really investing more into understanding the behavior of the models. Of course, others started working on these models sooner by investing more engineering resources or relying on partially closed software. The fully open and distributed ecosystem takes a long time to get going on some new models. All of this is lead-in for the most important question for open models — how easy is it to adapt to specific use-cases? This is a different problem for different model sizes. Large MoE open-weight models may be used by entities like Cursor who need complex capabilities in their domain, e.g. Composer 2 trained on Kimi K2.5. Other applications can be built on much smaller models, such as Chroma’s Context-1 model for agentic search, built on GPT-OSS 20B. The question of “which models are fine-tunable” is largely background knowledge known by engineers across the industry. There should be a thriving research area here to support the open ecosystem model. The first step is to understand characteristics of different base and post-trained models to understand what they look like. The second step is to tune pretraining recipes for open models so they’re more flexible. Interconnects AI is a reader-supported publication. Consider becoming a subscriber. Subscribe For The ATOM Project and other Interconnects endeavors, we’ve put in substantial effort to measuring adoption trends in the open ecosystem. Everything takes a long time to unfold after a model is first publicly available — and adaptability is why. What we know for sure now, when Qwen has been going from strength to strength with its releases, is that technical staff across the industry has gotten comfortable working with Qwen models. Countless research methods and datasets were made to work with Qwen. It’ll take patience for any other model family to get to this point — a patience I’m not sure many open model builders have. This takes us to Gemma 4, Google’s latest open models. Gemma 3 was released more than a year ago, in March of 2025, and is a bit underrated. Gemma 4 comes in 4 sizes for now, with a bigger, MoE model of over 100B total parameters rumored but not released yet. The models we have today come in sizes of ~5B dense, 8B dense, 26B total 4B active MoE, and 31B dense. I’m most excited that they’re finally adopting a standard Apache 2.0 open source license. This’ll massively boost adoption. The standard of better licenses for strong open-weight LLMs was set by mostly Chinese open model labs in the last 1-2 years, and now U.S. companies are following suit. I will personally be so happy if the horrible Llama licenses and Gemma terms of service were an ~18-month transient dynamic of the industry being nervous about releasing strong open models. The Gemma 4 scores look very solid, the small models have incredible benchmark scores (especially in general domains like LMArena) and the 31B model rivals the recent Qwen 3.5 27B, which is the leading member of that class. The ~30B size range is an important one, as it’s accessible both to researchers and to enterprises looking to deploy the model in real use-cases. Where the 7B model scale is the default for tinkering and research, a 30B model is the default for seeing if an open model can unlock substantial value in your specific workflow — a good mix of intelligence, low price, tractability for downstream training, etc. This takes us back to the above adoption criteria I mentioned for open models and the bigger question — do I think Gemma 4 will be an overwhelming success? Previous Gemma models have been plagued by tooling issues and poorer performance when being finetuned. Gemma 4’s success is going to be entirely determined by ease of use, to a point where a 5-10% swing on benchmarks wouldn’t matter at all. It’s strong enough, small enough, with the right license, and from the U.S., so many companies are going to slot it in. I’m cautiously optimistic that Gemma 4 is going to work better here. Winds are shifting for open models built in America. We saw GPT-OSS go through a bumpy launch to become an overwhelming success. There’s a collective energy around the likes of Reflection, Arcee, Nemotron, Gemma, Olmo, and peers that show substantial demand for building new stacks around open models. There’s capital to be spent on AI stacks across the economy by those who want more ownership of everything, including the model. After launching The ATOM Project 240 days ago, the conversation is shifting into the next stage. Summer of 2025 was a crisis moment where the U.S. AI scene realized it can’t wait and figure out open models after building AGI. The two markets will capture different areas and proceed in parallel. Now that more companies in the U.S. are releasing strong models, we need to improve the ecosystem so that these models are easy to use, understand, and build value around. It’s the hard work to build another inflection point in these adoption plots I’ve been updating consistently, but that’s the work to be done. Join me in it. More data coming soon! Here’s a sneak peek:
Adapti, Inc. Completes Acquisition of Levelution Sports Agency, LLC, Expanding NIL and Athlete Representation Capabilities
DALLAS, TX / ACCESS Newswire / April 2, 2026 / Adapti, Inc. (OTCID:ADTI), a company developing AI technology to integrate sports and influencer management, today announced that it has completed
Movie Review: Jittery, edgy and magnetic, Riz Ahmed takes ‘Hamlet’ for a spin
Riz Ahmed’s tense, modern ‘Hamlet’ adaptation features a corporate, ‘Succession’-like setting.
Ohio State's Ryan Day explains Buckeyes' massive offseason transfer overhaul: 'Adapt or die'
The Buckeyes coach compared the current college football landscape to that of the dinosaurs
Apple Adjusts Studio Display XDR Pricing Weeks After Launch
Apple has quietly reduced the price of the Studio Display XDR when configured with the VESA mount adapter, dropping it from $3,299 to $2,899 – a $400 cut. The nano-texture VESA version has also dropped from $3,599 to $3,199. Apple has also reworked the purchasing pattern on its website, making the stand choice the first step in the configuration process instead of the glass selection. When the Studio Display XDR launched last month, both stand options cost the same $3,299.
Scientists just found DNA “supergenes” that speed up evolution
Hidden within fish DNA are powerful genetic twists that may explain one of nature’s biggest mysteries: how new species form so quickly. In Lake Malawi, hundreds of cichlid fish species evolved at lightning speed, and scientists now think “flipped” sections of DNA—called chromosomal inversions—are the secret. These inversions lock together useful gene combinations, creating “supergenes” that help fish rapidly adapt to different environments, from deep waters to sandy shores.
Apple Releases New Firmware for AirPods Max 2
Just ahead of the launch of the AirPods Max 2, Apple has released new firmware for the headphones. The updated firmware is version number 8E251. The AirPods Max 2 include the H2 chip, an upgrade over the H1. The H2 brings several new features like Live Translation, Adaptive Audio, Loud Sound Reduction, Voice Isolation, and more. The new firmware likely optimizes some of these new features. Customers who buy the AirPods Max 2 can follow Apple's steps to get the new firmware.
Coral reef science must adapt to have a chance to outpace climate change
Scientists call for a major acceleration in coral assisted evolution research to help reefs cope with rapidly warming oceans.
‘The Count of Monte Cristo’: Will Jeremy Irons Be Back as Abbé Faria?
The Oscar winner made his debut in Episode 2 of the 'Masterpiece' adaptation of the literary classic.
Scientists Stunned: Colossal Eggs Discovered 3,500 Meters Beneath an Active Volcano
Beneath an active seafloor volcano off Vancouver Island, researchers have documented a congregation of giant eggs at roughly 3,500 meters, a discovery that reframes how life can flourish under extreme conditions. The eggs belong to the Pacific white skate, an elusive deep‑sea species adapted to cold, crushing pressure and perpetual darkness. What seemed an unlikely nursery is actually a geothermally warmed refuge, where subtle heat helps embryos survive a marathon incubation. The finding links volcanic energy to a quiet engine of biodiversity, turning a hostile landscape into an incubator. A living volcano, a hidden nursery The seamount long assumed dormant now exhales mineral‑rich, shimmering plumes, proof of hydrothermal life at depth. Expedition cameras swept across black basalt and pale bacterial mats, revealing vents that pulse with warmth. That warmth, though modest by human standards, alters the physics of development for cold‑adapted embryos. In a realm where metabolism creeps, even a few degrees can mean faster growth and higher survival. The volcano is not only active; it is ecologically formative, drafting a blueprint for a thriving oasis. Giant eggs and a skate built for the abyss The Pacific white skate, Bathyraja spinosissima, is built for the abyss: broad wings, armored spines, and a life history that trades speed for endurance. Females lay outsized, rectangular “mermaid’s purses,” often 46–50 centimeters long, packed with rich yolk to fuel years of growth. In the frigid deep, embryos can require around four years to hatch, a timeline that magnifies every energetic advantage. The scale is striking—large eggs, large adults, and a textbook case of deep‑sea gigantism. The volcano’s gentle heat may literally shave months or years from the wait. Why heat matters at the bottom of the sea Hydrothermal circulation delivers low‑level warmth without the turbulence that would scatter fragile egg‑cases. Slightly elevated temperatures accelerate enzyme kinetics, nudging development along while keeping embryos within a safe range. Mineral‑laden fluids likely shape local microbiomes, which, in turn, can influence biofilms on egg surfaces. The environment acts like a slow, steady incubator, countering the deep sea’s tyrannies of cold and scarcity. For a species with long maturation and few offspring, every incremental boost compounds across generations. An ecosystem sculpted by fire and water Seafloor volcanoes create steep environmental gradients, stitching together hot vents, cool eddies, and mineral gardens into mosaic habitats. Microbes harvest chemical energy, seeding food webs that support crustaceans, fishes, and skates. Cameras documented egg‑cases nestled among rocky ledges, near communities nourished by vent‑driven chemistry. These islands of productivity behave like deep‑sea oases, sustaining life far beyond the vent orifice’s flickering light. The nursery’s success underscores how geological forces engineer biological opportunity. “Finding a cradle of life tucked beneath a breathing volcano reminds us that the planet’s harshest places can be profoundly generous.” What the discovery could change The nursery reframes conservation priorities in regions where volcanism quietly underwrites reproduction. Protecting hydrothermal corridors could safeguard entire lifecycles, not just charismatic adults spotted during occasional surveys. It also sharpens questions about how climate‑driven shifts in ocean circulation might influence vent activity, temperature fields, and embryo survival. With methodical mapping, time‑series cameras, and environmental DNA, scientists can track whether nurseries remain stable or drift with geologic rhythms. Key implications include: Enhanced understanding of deep‑sea reproduction at hydrothermal sites. New conservation targets centered on geothermal nurseries. Comparative studies with other volcanic regions, from the Galápagos to rift zones. Biotechnological insights from organisms adapted to long, cold development. Better models of how seafloor heat shapes regional biodiversity. Methods behind the revelation Remotely operated vehicles threaded through chimney fields, gathering video, temperatures, and mineral signatures. High‑definition imagery captured the distinctive, horned egg cases, their edges dusted with fine volcanic silt. Geochemical profiles mapped how heat and chemicals disperse, outlining the “thermal lanes” where eggs most cluster. Combined, these datasets reveal a nursery organized by geothermal topography, with egg‑cases concentrated in pockets of gentle, sustained warmth. A fragile boon in a changing ocean Deep‑sea environments feel remote, yet they intersect with global pressures: mining proposals, cable routes, and shifting oxygen levels. The nursery’s resilience hinges on stable heat flow, intact substrates, and minimal disturbance from noise or sediment. Safeguarding such places is not just about protecting novelty; it preserves a slow, ancient strategy that lets large, long‑lived animals endure in the coldest reaches of the Pacific. Where geology and biology meet, the planet’s deep time still writes living stories. This volcano‑warmed nursery adds a vital chapter to that story, revealing how subtle thermal gifts can tip the scales toward life in the abyss. With each dive, researchers trace the contours of an unseen world, where fire feeds water, and water—against all odds—feeds the future.
Polar bears are struggling in every aspect of their lives, but scientists are hoping to prevent extinction through genetic management
Polar bears are struggling to survive as Arctic ice disappears, limiting food, reducing habitat, and pushing their ability to adapt.
Here's some of the real science behind the science fiction film ‘Project Hail Mary’
The new science fiction film adaptation leans heavily on real science done by the National Aeronautics and Space Administration, more commonly known as NASA.
Here's some of the real science behind the science fiction film ‘Project Hail Mary’
The new science fiction film adaptation leans heavily on real science done by the National Aeronautics and Space Administration, more commonly known as NASA.
Here's some of the real science behind the science fiction film ‘Project Hail Mary’
The new science fiction film adaptation leans heavily on real science done by the National Aeronautics and Space Administration, more commonly known as NASA.
Poppy Playtime Chapter 6 Plans, Film Adaptation: Mob Entertainment
Survival horror game "Poppy Playtime" launched its fifth installment Feb. 18, breaking records set by the video game franchise's previous debuts.
iOS 26.4 is Here: 12 Settings to Change for Better Battery and Privacy
Master the new iOS 26.4 update with these 12 essential setting changes. From optimizing Liquid Glass UI to enabling Adaptive Power Mode.
Arts and Entertainment Agenda: March 27-April 3
Limitless Mountain Challenge, March 28 Challenge Aspen’s “Limitless Mountain Challenge” runs 8 a.m. to 4 p.m. March 28 at Snowmass Mountain. The all-abilities ski and snowboard event supports adaptive recreation, with a downhill ski and...
Roadmap Writers, Everard Entertainment Set Sonja O’Hara’s ‘Slay’ For Feature Development Following Competition Win; Scott Glassgold Producing
EXCLUSIVE: Sonja O’Hara has emerged as the inaugural grand prize winner of a new writing competition, aimed at discovering commercially viable short stories for feature adaptation, from Roadmap Writer...
New Fathers Face Mental Health Challenges, Study Finds
By Dennis Thompson HealthDay ReporterTUESDAY, March 24, 2026 (HealthDay News) — New fathers might be proud poppas, but their mental health might be shaky as they adapt to their increased responsibilities, a new study says. Men have a 30% increased risk of depression and stress disorders by the end ...
Will Blue Bloods Continue to Dominate Mach Madness in the NIL Era?
College basketball has changed because of NIL. The Big Ten has risen, old-school coaches have adapted, and the talent pool is deeper than ever.
Does PBS ‘Count of Monte Cristo’ Make Big Book Changes?
A recap of Episode 1 of the Sam Claflin and Jeremy Irons-led adaptation.
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
'That's why there's 9 billion of us and not 9 billion of some other primate': Why our ability to adapt is humanity's 'superpower'
Live Science spoke with Herman Pontzer, an evolutionary anthropologist and author of the book "Adaptable," about the science of human diversity.
Adaptive Sports & Recreation Expo taking place in Winston-Salem
The event will be held from 10 a.m. to 2 p.m. at the JDL Fast Track on Empire Drive in Winston-Salem.
Younger Chinese Americans are fighting to save traditions
Younger business owners are adapting to challenges their parents didn’t face: historic tariffs, dwindling adherence to tradition and lower foot traffic in a post-pandemic San Francisco.
How did these flowers evolve to survive a megadrought?
A multi-year megadrought in the Western U.S. has claimed untold populations of wild plants. Amid the conditions, some have survived. Scientists have produced a stunningly complete picture about how populations of one particular flower – the scarlet monkeyflower – made it through. In a new study published in the journal Science, a team of scientists spent decades studying and sampling select populations of scarlet monkeyflowers in California and Oregon. Through genetic sequencing, the team discovered that the populations that did best went through genetic changes in a short time period. This is known as rapid evolution. The team found that three of the populations that recovered the BEST adapted their stomata to open less, so they could conserve more water. Stomata act like a plant’s pores, managing gas exchange and water loss. This allowed the scarlet monkeyflowers to hunker down in the drought and survive. Interested in more stories about rapid evolution? Email us your question at shortwave@npr.org.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.Listen to Short Wave on Spotify and Apple Podcasts.This episode was produced by Jeffrey Pierre, Rachel Carlson and Hannah Chinn. It was edited by Christopher Intagliata and Rebecca Ramirez. Aru Nair checked the facts. The audio engineers were Becky Brown and Robert Rodriguez.
Hermès doesn’t include a power adapter with its $5,150 charging case
You can charge your Apple Watch and iPhone for the cost of three MacBook Pros.
Accenture Collaborates with Microsoft to Bring Agentic Security and Business Resilience to the Front Lines of Cyber Defense
NEW YORK, March 19, 2026--Accenture today announced new assets and capabilities for its Adaptive Managed Extended Detection and Response (MxDR).
What to watch this week in New Orleans theater: ‘Gatsby,’ ‘Streetcar,’ ‘Little Shop,’ more
Step into the Jazz Age with a lavish musical adaptation of F. Scott Fitzgerald's classic tale at the Saenger Theatre. Don't miss the chance to witness Jay Gatsby's larger-than-life story come alive on stage!
Samsung’s 65W Trio adapter can’t charge your Galaxy S26 Ultra at 60W
The 65W Trio adapter from Samsung can't charge the Galaxy S26 Ultra at 60W, and there's a reason behind this limitation.
UW Health resident creates adaptive crayons for children with disabilities
MADISON, Wis. — A physical medicine and rehabilitation resident at UW Health is reimagining crayons by creating adaptive crayons for people with developmental disabilities, stemming from her past experiences.
Ski For Life: Oregon adaptive sports program opens slopes to students with disabilities
An Oregon Adaptive Sports program allows young people with disabilities to participate in outdoors sports by providing them with adaptive equipment.
A ‘Hail Mary’ for Earth, Built on Solid Science
Andy Weir discusses his science-fueled novel “Project Hail Mary,” which has been adapted into a film that opens in theaters on Friday.
Kering adapts the presentation of its businesses, to align with its strategic model and organization
Kering - Press release - Segment reporting - EN - 16 03 2026 PRESS RELEASEMarch 16, 2026 KERING ADAPTS THE PRESENTATION OF ITS BUSINESSES, TO ALIGN WITH ITS STRATEGIC MODEL AND ORGANIZATION As part of the evolution of its strategy and organization, which will be presented in detail on April 16, 2026, during its Capital Markets Day, Kering announces a new segmentation of its businesses. This new presentation enhances the clarity of Kering strategic model, highlights the momentum of each of its bu
Apple Announces AirPods Max 2
Apple today unveiled AirPods Max 2, with key upgrades including the H2 chip, increased active noise cancellation, improved sound quality, and features such as Adaptive Audio, Conversation Awareness, Voice Isolation, and Live Translation. AirPods Max 2 have the same overall design as the original AirPods Max, with most of the new features coming from the upgrade to the H2 chip.
Business majors preparing for the future
The third annual Arizona Statewide Business School Case Competition (ASBSCC), coming to Northern Arizona University, provides students with the opportunity to apply their knowledge and test their soft skills—communication, leadership, adaptability, networking and collaboration—by placing them in realistic business scenarios that demand quick thinking and effective teamwork. This collaborative effort between Arizona State University, the University of Arizona and NAU allows students to work across institutional lines to…
Strengthening One Health Field Epidemiology Capacity in the WHO South-East Asia Region
Recent public health emergencies—including the COVID-19 pandemic, recurrent zoonotic disease outbreaks, and the high level of antimicrobial resistance—have underscored the urgent need for strong, multisectoral field epidemiology capacities. This reinforces the importance of a workforce equipped with One Health field epidemiology competencies. To address this need, WHO works with the Food and Agriculture Organization of the United Nations (FAO), the United Nations Environment Programme (UNEP), and the World Organisation for Animal Health (WOAH), as part of Quadripartite Alliance for One Health, to strengthen field epidemiology training programmes using a One Health approach.These efforts are aligned with WHO SEARO’s Strategic Framework for Action for Strengthening Surveillance, Risk Assessment and Field Epidemiology and the Regional Roadmap to Advance Field Epidemiology Capacities 2025–2029 emphasize workforce development, multisectoral collaboration, and enhanced preparedness for health emergencies. With funding from the Pandemic Fund, The Competency for One Health Field Epidemiology (COHFE) integration within Field Epidemiology Training Programmes (FETPs) or similar initiatives has been initiated in Bangladesh and India and is planned in Sri Lanka.BangladeshIn Bangladesh, COHFE is being adapted to strengthen the Field Epidemiology Training Programme, Bangladesh (FETP-B) Advanced programme. Initiated in July 2025 and led by the Institute of Epidemiology, Disease Control and Research (IEDCR), the process brought together stakeholders from human, animal, and environmental health sectors, academia, and laboratories.A Multisectoral Working Group (MWG) was established to guide implementation, conduct readiness assessments, and identify opportunities to institutionalize One Health collaboration. Through national multisectoral consultations and a competency prioritization workshop held in Dhaka in November 2025, stakeholders identified priority technical competencies for surveillance, outbreak investigation, data analysis, and risk assessment, alongside functional competencies related to leadership, coordination, and the laboratory–epidemiology interface. The process also surfaced systemic barriers—such as challenges in data sharing and limited joint investigations—enabling targeted recommendations. These outcomes are guiding curriculum revision, the introduction of One Health simulations and joint field exercises, and the development of a national multisectoral mentorship pool, with updated training materials expected to be implemented in the upcoming cohort.Figure 1. Competency prioritization involving multisectoral stakeholders“COHFE represents a significant step forward in operationalizing the One Health approach. The collaboration between national institutions and the Quadripartite partners is critical for building resilient systems to address complex health challenges in the region.”, Prof. (Dr) Tahmina Sirin, Director, Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh.Aligning India’s One Health Training with COHFEIn India, the National Centre for Disease Control (NCDC) has strengthened One Health workforce development through its SectorConnect initiative. WHO supported a comprehensive competency mapping and curriculum review to align the Field Epidemiology Programme in One Health (FEP-OH) with all 14 COHFE domains. The review identified strong foundations while generating actionable recommendations to strengthen One Health learning outcomes, expand joint field-based learning, and enhance competency-based assessment. These improvements are informing programme refinement and phased scale-up across additional states.Figure 2. Strengthening learning outcomes for the SectorConnect FEP OH CurriculumThrough these efforts, WHO SEARO will continue to support countries to move from separate sector-based training toward an integrated, impact-driven One Health field epidemiology workforce capable of addressing complex health threats at human-animal-environment interface.ReferencesFood and Agriculture Organization of the United Nations, World Health Organization, & World Organisation for Animal Health. (2024). Competencies for One Health field epidemiology (COHFE) framework. https://www.who.int/publications/i/item/9789240080058World Health Organization. (2023). Strategic framework for action for strengthening surveillance, risk assessment and field epidemiology for health security threats in the WHO South-East Asia Region. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290210030World Health Organization. (2024). Regional roadmap to advance field epidemiology capacities in the WHO South-East Asia Region 2025–2029. WHO Regional Office for South-East Asia. https://www.who.int/publications/i/item/9789290229544
LeBron James' adaptability a key in victory over the Bulls
The 41-year-old forward is letting Luka Doncic and Austin Reaves control the offense, but he continues to find ways to impact the game on both ends of the court.
Ryan Gosling talks Project Hail Mary, hopeful science fiction and the challenge of portraying zero g
Ryan Gosling plays a science teacher turned (reluctant) astronaut in the upcoming film adaptation of Project Hail Mary, a science fiction novel by author Andy Weir
‘Back to the Future’ musical tour is all spark, no substance
Adapted from the 1985 sci-fi hit, “Back to the Future” has fun visual stunts and self-mocking moments. The tour runs in Madison through March 15.
Health IT leaders must adapt to the circuitous route of prescriptions
Hospital and health system CIOs should map current prescription workflows in detail and prioritize interoperability with clear governance frameworks, advises Joseph Kleiman, president of Rx tech company Buzz Health.
Healthcare Uses Specialized Language. It Needs Specialized AI, Too.
The potential generative AI in healthcare is enormous. They can generate patient education materials or clinical notes in seconds, flag incomplete documentation to keep care on track, or even suggest differential diagnoses . But when generalist models encounter the specialized “dialects” used across medical fields, they can miss critical clinical meaning—even when they read every word correctly. The result can be flawed decisions and eroding clinician trust. Healthcare organizations should treat AI like a supervised trainee: adapt models to clinical specialties, require transparent reasoning, and calibrate automation with human oversight.
Marcus Rashford: Barcelona dream under threat in latest development
Manchester United sent Marcus Rashford out on loan last summer to FC Barcelona.Form at FC BarcelonaThe Englishman adapted to life quickly in the Catalan capital and began to provide assists and score ...
Ocean warming may supercharge a tiny microbe that controls marine nutrients
As deep-sea waters warm, scientists expected trouble for the microbes that help keep ocean chemistry in balance. Instead, researchers found that Nitrosopumilus maritimus can adapt to warmer, iron-limited conditions by using iron more efficiently. Because these microbes control key nitrogen reactions that support marine life, their adaptability could help sustain ocean productivity. In a warming world, they may play an even bigger role in shaping marine nutrient cycles.
Iranian Military Shows It Knows How to Adapt, U.S. Officials Say
Iran appears to be targeting what it views as American vulnerabilities, including air defenses meant to guard troops and assets in the region.
Nicole Kidman and Jamie Lee Curtis adapt ‘Scarpetta’ book series for TV
Nicole Kidman and Jamie Lee Curtis met at the Oscars in 2021.
Women Veterans Appreciation Event fosters community through adaptive sports
The New England Healing Sports Association hosts an empowering winter sports event for women veterans, fostering connection and healing through adaptive skiing.
Nordic Semiconductor introduces precise, adaptive battery health-monitoring to enable smarter, longer-lasting IoT devices
Nordic Semiconductor, a global leader in low-power wireless connectivity solutions, today announces Nordic Fuel Gauge v2.0, a major upgrade of its highly accurate software-based fuel gauge solution for the award-winning nPM1300, and nPM1304 Power Management ICS, at Embedded World 2026. The release adds sophisticated State-of-Health estimation, adaptive battery modeling, and long-term fleet analytics capabilities, extending advanced battery management to a wide range of power-constrained IoT prod
Introducing Hims & Hers Benefits, Unlocking Health & Wellness Discounts for Subscribers
The program debuts with Prenuvo and Eight Sleep, providing discounts on advanced diagnostics and sleep technology Hims Hers Health, Inc. (NYSE: HIMS), the leading health and wellness platform, today announced Hims Hers Benefits, a new way for subscribers to access the best innovations in whole body health. This new initiative provides active subscribers access to discounts from health partners, all in one place, including whole body MRI scans from Prenuvo and adaptive bed systems from Eight Sleep. This is just the beginning of a larger benefits program that will make comprehensive, holistic care more accessible and affordable for subscribers. “True health doesn’t happen in a vacuum. It’s the result of the data you gather, the insights you can access, and the daily choices you make,” said Dheerja Kaur, Chief Product Officer at Hims Hers. “By leveraging our scale, we’re bringing health and wellness innovations like Prenuvo’s whole body MRI scans and Eight Sleep’s
This 2-pound dinosaur is rewriting what scientists know about evolution
A nearly complete dinosaur skeleton discovered in Patagonia is helping scientists crack the mystery of alvarezsaurs, a bizarre group of bird-like dinosaurs. The fossil of Alnashetri cerropoliciensis reveals that these animals became tiny before developing their later specialized features, such as stubby arms and ant-eating adaptations. Weighing under two pounds, the dinosaur is one of the smallest known from South America.
How Taiwan Is Reclaiming Its Wine Identity—Through Climate-Adaptive Science and Terroir-Driven Fermentation
Entertainment Spotlight: Christian Bale on his adaptation of Frankenstein in ‘The Bride!’
Christian Bale is "Frankenstein" in ‘The Bride!’
Building climate-ready healthcare facilities across Indonesia
The World Health Organization (WHO), working with the Ministry of Health and partners, developed the Climate-Resilient and Environmentally Sustainable Health Care Facilities assessment tools. These were adapted from WHO's global framework and integrated into the SIKELIM platform, a digital system that maps disaster-affected facilities in real time. The tools help facilities assess vulnerabilities across systems including workforce capacity, water and sanitation WASH and waste, energy, infrastructure and technology.
3L Kevin Afiesh Learns to Translate Legal Risk Into Business Strategy as FinTech Extern - UC Law San Francisco (Formerly UC Hastings)
3L Kevin Afiesh strengthened his corporate and fintech skillset through an externship at Plaid, gaining real-world experience at the intersection of technology and financial services. 3L student Kevin Afiesh shares how UC Law San Francisco’s Corporate Counsel Externship provided immersive, practice-ready training inside Plaid’s in-house legal department. Reviewed and analyzed technology-focused agreements, including emerging AI provisions and liability terms Explored financial services regulation and data governance within a growth-stage company Learned how internal legal teams shape product, partnership, and compliance planning 3L student Kevin Afiesh: During my externship at Plaid, I worked with the in-house legal team supporting a rapidly growing company at the intersection of technology and financial services. My work focused primarily on corporate, commercial, and intellectual property matters. I helped review and analyze vendor and partnership agreements, paying close attention to emerging artificial intelligence-related provisions and risk allocation terms. I also investigated regulatory and compliance issues involving financial services and data governance, and I researched intellectual property litigation relevant to fintech companies. This work supported legal risk assessment to guide strategic decision making. I learned firsthand how an in-house legal team operates in a highly regulated, innovation-driven environment, where legal analysis is closely integrated with business decision making. I saw how attorneys balance legal risk with commercial priorities and how their advice shapes contracting, compliance, and intellectual property strategy. It reinforced that effective in-house lawyers need to understand both the law and the operational realities of the business. The experience also strengthened my ability to communicate complex legal concepts clearly to non-lawyers and to provide advice that is precise, practical, and commercially aware. Throughout my academic and professional journey, I’ve worked with technology companies at different stages. Plaid added a distinct perspective within the tech ecosystem, showing me how a growth-stage fintech company approaches regulatory complexity, innovation, and risk tolerance. This sharpened my ability to adapt to clients with different structures, priorities, and compliance needs. As I prepare to practice corporate law in the technology industry, this exposure has strengthened my ability to align legal advice with a company’s stage of growth, strategic objectives, and internal dynamics. I would absolutely recommend the Corporate Counsel Externship Program. Working directly with an in-house legal team provided a meaningful sense of day-to-day practice inside a technology company, and the attorneys at Plaid were generous with their time and mentorship. The classroom component was equally valuable. Professors Nira Geevargis and Scott Darling created a thoughtful environment where we reflected on our experiences, discussed real-world challenges, and developed practical skills that complemented our fieldwork. More broadly, UC Law San Francisco’s location offers a clear advantage for students interested in technology, corporate practice, and public-interest work. Proximity to courts, law firms, and innovative companies — combined with programs like the Corporate Counsel Externship and an extensive Bay Area alumni network — make it a strong option for students who want to build their careers in the region. The Evidence of Success series highlights UC Law SF students as they share how the college’s opportunities equip them with the experience, skills, and confidence to excel in the legal profession.
Apple Does Not Include a Charger With All New MacBooks in UK and EU
None of the new MacBook Neo, MacBook Air, or MacBook Pro models unveiled this week come with a charger in the UK and EU countries, such as Germany, France, Italy, and Spain. This change began with the base 14-inch MacBook Pro last year. If you need a power adapter, you must purchase one separately during checkout or later. In all other countries, Apple includes a charger in the box with these Macs, at no additional cost.
How Mixed-Use Sports and Entertainment Districts Create Year-Round Economic Value
From stadium-anchored destinations to experience districts, successful mixed-use sports and entertainment developments are evolving into adaptable, community-centered places that deliver cultural relevance, financial performance, and economic activity every day.
RSC's ‘Hamnet’ disappoints a little
I've been thinking about my reactions to the Royal Shakespeare Company and Neal Street Productions' “Hamnet” ever since Lolita Chakrabarti's adaptation of Maggie O'Farrell's 2020 historical novel had its North
'I needed to show I want to be here'
Everton striker Beto has said he needs "to adapt, keep working" and "show I want to be here" after scoring on his first start of 2026 in Saturday's 3-2 win at Newcastle. "I want to keep playing more - starting and helping the team," said Beto.
PsychAdapter: adapting LLMs to reflect traits, personality, and mental health
npj Artificial Intelligence - PsychAdapter: adapting LLMs to reflect traits, personality, and mental health
What to watch as the midterms begin with Tuesday's primaries
The first primaries of the 2026 election season will offer an early read on voter mood in President Donald Trump’s second term and on how both parties are adapting
argenx Reports Full Year 2025 Financial Results and Provides Fourth Quarter Business Update
$1.3 billion in fourth quarter and $4.2 billion in full year global product net sales, representing 90% year‑over‑year growth Delivered $1.1 billion in operating income in 2025, marking first year of operating profitability VYVGART MG label expansion supported by positive ADAPT SERON and OCULUS results; PDUFA target action date of May 10, 2026 for anti‑AChR antibody‑negative (“seronegative”) gMG Management to host conference call today at 2:30 PM CET (8:30 AM ET) February 26, 2026 7:00 AM CET Am
Samsung Unveils All New Galaxy Buds4 Series With Ultimate Sound
Samsung audio innovation delivers original sound as intended and intelligent adaptive controls for every environment
Credit card surcharges rise as small businesses adapt
Businesses are changing how they accept payments, from credit card surcharges to going cashless. Find out why and how customers are reacting.
2026 Business Leaders of the Year
Central Massachusetts is full of amazing professionals, each with their own unique skills, talents, and dedication to their companies, industries, and communities. You could make a strong case for hundreds of them to be considered as WBJ’s Business Leader of the Year. Yet, to actually win the award, you need to have that little something extra: a magic spark, an insight no one else sees, years of knowledge that pay off with the right decision at the right time, a leadership style inspiring people to follow, a push for a paradigm shift at a stagnant organization. Business Leader of the Year is WBJ’s oldest award, launched in 1982 when Herb Dunnington of First Safety Fund Bank won the sole award. In the decades since, BLOY has expanded to honor winners from different corners of the economy: small businesses, large businesses, nonprofits, innovation, families. Each of the six winners this year has that something special setting them apart as true leaders in our Central Massachusetts business community: Neelu Mohaghegh’s creativity, Nick Haritos’ compassion, Nicolette Sacco’s adaptability, Julie Bowditch’s energy, Sean Rose’s steadiness, the Vaccaro family’s culture. You can read more about each of them through the links below.
‘Wuthering Heights’ reaches remarkable lows: subpar adaptation
Released on Feb. 13, “Wuthering Heights” has acquired approximately $83 million in gross revenue from the box offices globally since premiering, with numbers continuing to climb. Starring Margot Robbie as
PRET for impact: Advancing pandemic preparedness in the Democratic People’s Republic of Korea
IN THE SPOTLIGHT PRET for impact: Advancing pandemic preparedness in the Democratic People’s Republic of KoreaThe Democratic People’s Republic of Korea (DPR Korea) is making significant progress in strengthening pandemic preparedness, with dedicated support from the WHO South‑East Asia Regional Office (SEARO) and the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC).Aligned with the WHO Global Influenza Strategy and the Pandemic Influenza Preparedness (PIP) Framework Partnership Contribution High‑Level Implementation Plan III (2024–2030), the country is strengthening its capacity to prepare for and respond to influenza and other respiratory threats. In early 2025, a core team from the Ministry of Public Health of the Democratic People’s Republic of Korea (DPRK) participated in a two‑day virtual workshop, which included a mini‑simulation exercise. The workshop was organized by WHO SEARO in collaboration with the Preparedness and Resilience for Emerging Threats (PRET) Secretariat at WHO headquarters and the WHO Country Office for the DPRK. Read more A REGIONAL CONSULTATION GUIDES WHO SEARO IN DEVELOPING A ROADMAP FOR IMPLEMENTING THE PREPPAREDNESS AND RESILIENCE FOR EMERGING THREATS (PRET) INITIATIVE BASED RESPIRATORY PATHOGEN PANDEMIC PREPAREDNESSInfluenza and other respiratory pathogens with pandemic potential continue to pose major public health risks globally. To strengthen regional preparedness and response, Member States of the WHO South‑East Asia Region (SEAR) convened in Colombo, Sri Lanka, to review and provide input on the draft Roadmap and Action Framework for Broad Respiratory Pathogen Pandemic Planning (2026–2031). Supported through the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC) funds, the proposed roadmap aims to advance robust, integrated preparedness and response capacities for influenza and other respiratory threats across SEAR. This work is aligned with the Preparedness and Resilience for Emerging Threats (PRET) initiative and the SEAR Strategic Roadmap on Health Security and Health System Resilience for Emergencies Read moreSRI LANKA’S USE OF ANTIVIRALS TO REDUCE THE SEASONAL INFLUENZA BURDEN Sri Lanka is strengthening its influenza response by placing greater emphasis on rapid testing, timely treatment, and integration with maternal health services. With support from WHO, the country is building a stronger evidence base on the burden of influenza and the value of vaccination, advancing a holistic approach to protect vulnerable populations and enhance pandemic preparedness. To reduce hospitalizations and deaths from seasonal influenza, Sri Lanka is taking proactive steps to expand access to rapid diagnostic testing and ensure prompt initiation of treatment. National clinical guidelines recommend the use of oseltamivir for individuals at high risk of complications, helping prevent severe illness and shorten the duration of infection. This strategy not only saves lives but also supports local pharmaceutical production, contributing to a reliable supply of antivirals for both seasonal outbreaks and future pandemics.Read moreBHUTAN BOOSTS PANDEMIC INFLUENZA READINESS WITH PANDEMIC INFLUENZA PREPAREDNESS FRAMEWORK PARTNERSHIP CONTRIBUTION SUPPORTED TRAINING AND SIMULATIONSOriginally developed in 2012, the National Influenza Pandemic Preparedness and Response Plan (NIPPRP) has long served as Bhutan’s central framework for managing influenza threats. In 2024, the plan underwent a comprehensive update to reflect evolving global and regional guidance, lessons learned from the COVID‑19 pandemic, and new capacities developed under the PIP Framework. The revised NIPPRP is now more clearly aligned with Bhutan’s broader emergency and disaster risk management structures, ensuring a coordinated, whole‑of‑government approach to pandemic response. As part of efforts to strengthen national pandemic preparedness, Bhutan conducted three national‑level training sessions followed by simulation exercises on influenza pandemic preparedness and response at five sentinel hospitals between April and May 2025, with support from the PIP Partnership Contribution (PC). These activities brought together more than 140 health professionals and key partners from across the country, with a focus on operationalizing the updated NIPPRP and enhancing readiness at key frontline facilities. Read moreSTRENGTHENING INFLUENZA SURVEILLANCE: WHO BRINGS TOGETHER INFLUENZA EXPERTS FROM SOUTH-EAST ASIA AND WESTERN PACIFIC REGIONSThe World Health Organization (WHO) convened the 18th Bi‑regional Meeting of National Influenza Centres (NICs) and Influenza Surveillance for the WHO South‑East Asia and Western Pacific Regions from 9–11 September 2025. Hosted by the WHO South‑East Asia Regional Office (SEARO), the meeting brought together representatives from Member States, Territories, and Areas across both regions, alongside experts from the WHO Collaborating Centres for Reference and Research on Influenza in Australia and Japan, the WHO Collaborating Centre for Studies on the Ecology of Influenza in Animals in the United States, quadripartite partners (WOAH and FAO), and other technical counterparts. The consultation provided a platform to review progress, share experiences, and outline priorities for strengthening influenza and respiratory pathogen surveillance across the two WHO regions.Read moreNETWORKS AND TECHNICAL PARTNERSHIPSSTRENGTHENING PANDEMIC READINES: SOUTH-EAST ASIA ADVANCES UNITY STUDIES UNDER THE PANDEMIC INFLUENZA PREPAREDNESS INITIATIVEThe WHO Global Influenza Surveillance and Response System (GISRS) Investigations & Studies initiative, also known as Unity Studies, provides a standardized, globally coordinated framework to support these efforts. Originally developed for influenza and adapted during COVID-19, Unity Studies enable countries to conduct rapid, nationally led investigations and studies to assess transmissibility, severity, susceptibility, and intervention effectiveness. To better prepare for future influenza pandemics, WHO has recently launched a network of sites which will be ready to conduct these investigations and studies rapidly in the event of a pandemic, or epidemic of an emerging or re-emerging respiratory pathogen. The WHO South-East Asia Region now hosts six sites of WHO GISRS Unity Studies across the five countries including Sri Lanka, strengthening regional capacity for early pandemic investigations. From 13–16 July 2025 in Colombo, the Global Public Health Summit offered an opportunity to advance this agenda. Read moreSTRENGTHENING PANDEMIC PREPAREDNESS THROUGH UNITY STUDIES: REAL-WORLD APPLICATIONS FROM INDIA IN WHO’S SOUTH-EAST ASIA REGION As countries continue to strengthen their pandemic preparedness through investments in resilient health systems during the interpandemic period, the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS) Investigations & Studies Global Initiative, Global Initiative, commonly known as Unity Studies, remains a vital framework for respiratory pathogen pandemic preparedness. These standardized epidemiological protocols enable countries to rapidly generate high‑quality data on transmissibility, infection severity, population immunity, and the effectiveness of public health interventions. To highlight how Unity Studies protocols are being adapted and applied in national settings, WHO Headquarters, together with WHO Regional Offices, including the WHO South‑East Asia Regional Office (SEARO), hosted a global webinar. The session showcased case studies from India and the United Kingdom (UK), demonstrating innovative approaches to respiratory virus surveillance and pandemic readiness. Read moreSTRENGTHENING REGIONAL INFLUENZA SURVEILLANCE AND PREPAREDNESS: WHO SEARO HOSTS HIGH-LEVEL WEBINAR AMID RISING H5 THREATS In response to the increasing detection of avian influenza A(H5) cases in humans globally and within the WHO South‑East Asia Region, the WHO Regional Office for South‑East Asia (SEARO) convened a regional webinar on 25 July 2025 to review preparedness mechanisms, strengthen surveillance pathways, and promote timely reporting of unusual respiratory events. The virtual session brought together more than 50 participants from Ministries of Health, National Influenza Centres (NICs), National IHR Focal Points (NFPs), WHO Headquarters, WHO Country Offices across the Region, and WHO Collaborating Centres (CCs) for influenza. The webinar provided an opportunity to share situational updates, discuss surveillance gaps, and reinforce coordination mechanisms critical for early detection and rapid response to avian influenza threats. Read moreOther Key PIP Updates (July-December 2025)MEMBER STATES:Bangladesh drafted and conducted a series of Core Group Meetings in 2025 to review and update the National Pandemic Preparedness and Response Plan for Respiratory Pathogens. In addition, the country carried out Rapid Response Team (RRT) trainings on seasonal and avian influenza and other re‑emerging infectious diseases. Bangladesh also updated its epidemiological data‑training programme for physicians at sentinel surveillance sites, using a revised epidemiological data‑collection tool.Bhutan revised and updated its National Influenza Pandemic Preparedness and Response Plan (NIPPRP) in 2025 and developed a national Standard Operating Procedure (SOP) for influenza outbreak management. DPR Korea conducted a nationwide simulation exercise in July 2025 to support the update of its National Influenza Pandemic Preparedness Plan (2019). This followed a PRET‑based virtual orientation and mini‑simulation exercise held in May 2025 by SEARO and the WHO PRET Secretariat. The comprehensive exercise, conducted across central and provincial levels, assessed strengths and gaps in pandemic influenza preparedness and response. The feedback gathered has been incorporated into the revised draft plan to address identified weaknesses and strengthen overall readiness.India conducted a targeted nationwide online re‑orientation training on review and updates to the influenza portal for all State Surveillance Officers (SSOs) and relevant officials using the Integrated Health Information Platform (IHIP). The training emphasized correct marking and reporting of influenza samples as “unsubtypable” or “not subtyped” where applicable, to ensure accurate national surveillance.Maldives conducted simulation exercises in three atolls based on its existing National Pandemic Preparedness and Response Plan (NPPRP). The country plans to conduct similar exercises in three additional atolls after updating the NPPRP in 2026. In addition, Maldives conducted training on FluID and FluMart as part of a broader data‑management training package for Ministry of Health and Health Protection Agency officials, aimed at improving routine reporting to WHO platforms and the DHIS2 system.In Myanmar, technical support was provided to the National Influenza Centre (NIC) through dedicated human‑resource support (January–December 2025) to sustain data management and laboratory detection capacity for influenza and other emerging and re‑emerging respiratory viruses. This support also included strengthening genomic sequencing capacity.Nepal conducted a consultative workshop on the National Pandemic Preparedness and Response Plan (NPPRP) in July 2025. The workshop engaged key stakeholders from multiple sectors to review lessons from past pandemic responses, assess current mechanisms, and gather critical inputs for strengthening national preparedness. Key recommendations included revising the 2019 NPPRP and developing an updated Influenza Pandemic Preparedness Plan aligned with emerging risks, national priorities, and relevant international frameworks. Nepal also held a two day workshop dedicated to advancing the National Action Plan for Genomic Surveillance, aimed at reinforcing the country’s capacities for early detection and monitoring of emerging respiratory pathogens.Sri Lanka received the final report from WHO on the feasibility assessment for conducting an Influenza Burden of Disease (BoD) study in the country. The assessment, conducted from 28 April to 9 May 2025, included a desk review of existing data sources, document review, visits to sentinel surveillance sites, and key informant interviews. The study identified critical data sources required for a future BoD assessment, as well as their availability and quality. Officials from the Epidemiology Unit, the National Influenza Centre (NIC), and SARI/ILI sentinel hospitals across the country participated in the assessment.Timor Leste conducted on‑the‑job training and monitoring activities at two sentinel surveillance sites to strengthen surveillance and laboratory capacity for the detection of SARI, ILI, ARI, and other respiratory infections. REGIONAL OFFICE:SEARO conducted a Member States Consultation on the first draft of the Regional Roadmap and Strategic Action Framework for implementing WHO’s PRET‑based broad respiratory pathogen pandemic planning for 2026–2031. The consultation took place on 29–30 October 2025 during the final two days of the Regional PIP PC Annual Review and PRET Meeting in Colombo, Sri Lanka. Participants included representatives from Member States, WHO Country Offices, WHO SEARO, WHO Headquarters, partner agencies, and invited multidisciplinary technical experts. They reviewed the draft and provided detailed feedback, which has since been incorporated into a revised version. The consultation helped shape a shared regional vision for robust, PRET‑aligned pandemic preparedness, building on country‑level progress, addressing existing gaps and challenges, and aligning with global and regional health security frameworks. The publication is planned for release during the SEAR regional committee in 2026.SEARO documented the evolution of the National Influenza Pandemic Preparedness Planning process in the Region, tracing its development from its origins as a planning tool for responding to avian influenza outbreaks in 2006, through the experiences of the 2009 and 2019 pandemics, to the current status. The document outlines the way forward for respiratory pathogen pandemic planning across all 10 SEAR countries, aligning future national plans with WHO’s PRET Framework for broad respiratory pathogen pandemic preparedness.The Infectious Hazard Management (IHM) Unit has drafted the WHO South‑East Asia Regional Guidance on Influenza Prevention and Control, aligned with the Global Influenza Strategy and other regional initiatives. The draft is currently under review. Although this technical product was developed in response to a request from the Ministry of Public Health of the Democratic People’s Republic of Korea (MoPH‑DPRK), SEARO is finalizing it for use not only in DPRK but also across all Member States in the Region.The Immunization and Vaccine Development (IVD) Unit, in collaboration with WHE/SEARO, completed a regional landscape analysis on key barriers, challenges, and opportunities for the introduction of seasonal influenza vaccination in WHO South‑East Asia Regional (SEAR) countries.Additionally, the Immunization and Vaccine Development (IVD) Unit has completed a regional landscape analysis of influenza vaccine procurement systems across the WHO South‑East Asia Region (SEAR).KEY MEETINGS AND PUBLICATIONSMEETINGS:Six-month progress review of the implementation of the PIP-PC workplans in SEAR, focusing on Outputs 1 and 2 for the period January to June 2025, and held virtually across three sessions on 4, 8, and 10 July 2025. Read moreAnnual Regional Meeting (Hybrid) on Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC) and WHO’s Preparedness and Resilience for Emerging Threats (PRET) Implementation in SEAR in Colombo, Sri Lanka, 27 to 30 October 2025. Read more18th Bi-regional Meeting (Virtual) of National Influenza Centres (NICs) and influenza surveillance in WHO South-East Asia and Western Pacific Regions from 9 to 11 September 2025. Read morePUBLICATIONSImplications of influenza A virus surveillance in Southeast Asian Region countries: a scoping review of approaches for the surveillance of swine influenza viruses at human-swine interfaces. Read moreAnnual South-East Asia regional meeting on operational planning for implementation of global influenza strategy and preparedness for respiratory viruses in 2025 Report on annual review meeting of implementation of pandemic influenza preparedness (PIP) partnership Contribution (PC) Fund in South-East Asia Region and the simulation exercise on PRET Status of influenza in who south-East Asia Region
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