SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " blood " 1,027 found 🔀 AI-powered Shuffle
Chris Bosh on Health Big Contracts and LeBron’s Future
Chris Bosh on LeBron to Miami, NBA expansion, blood clot awareness, big contract realities, and NIL.
Chris Bosh on Health Big Contracts and LeBron’s Future
Chris Bosh on LeBron to Miami, NBA expansion, blood clot awareness, big contract realities, and NIL.
Sunlight Boosts Fertility? What Scientists Have Discovered Will Surprise You - Futura-Sciences
Vitamin D, Sunlight, and Sperm: Digging Into the Science A meta-analysis published in the journal Biomedicines reviewed several observational studies that all pointed to a significant link between vitamin D levels—which are mainly produced in humans through sunlight exposure—and sperm characteristics. These studies also suggested a connection between higher blood...
Apple loses bid to overturn $634 million Masimo patent verdict
Apple’s requests to overturn a $634 million patent verdict and secure a new trial in its long-running legal battle with Masimo were denied.
Apple's $634M payment to Masimo now set in stone after Judge tosses appeal
The Masimo trial ultimately failed to get a permanent ban on Apple Watch sales or use of the blood oxygen sensor, but the final verdict will have Apple pay $634M to Masimo's new owner Danaher after the appeal was rejected.
Wilson Sonsini Advises Freenome on IP Matters Related to Business Combination, Public Company Launch
On July 20, 2026, Freenome Holdings, Inc. (Freenome), an early cancer detection company developing blood-based screening tests, announced the closing of its previously announced business combination…
Bandai Namco Entertainment details a fully playable GAMESCOM 2026 line-up
Bandai Namco reveals its gamescom 2026 line-up: ACE COMBAT 8, DRAGON BALL XENOVERSE 3 & The Blood of Dawnwalker, all playable at Hall 6.1, booth A20/B021.
This Wearable Aims to Improve Your Blood Pressure. It’s Now in the US, and I Got a First Look
People in Europe who used the wearable significantly improved their blood pressure readings over six months.
Coffee may protect your heart but energy drinks could harm it
For most adults, a daily caffeine habit may be safer for the heart than many people assume. A new American Heart Association review found that up to 400 milligrams of caffeine a day, roughly three to five cups of regular black coffee, is generally safe and may even be linked to lower risks of heart disease, stroke, heart failure, and Type 2 diabetes. But the source matters: highly concentrated energy drinks and shots can sharply raise blood pressure and trigger irregular heart rhythms.
The Witcher 3: Wild Hunt — Songs of the Past Reveal Date Confirmed
The Witcher 3: Wild Hunt — Songs of the Past will be revealed at gamescom 2026 during Opening Night Live, CD Projekt has announced.
Scientists Find a More Precise Way to Grow Artificial Blood Vessels, Using Magnets
Essential for lab-grown organs.
MTG pounces on Hegseth, claiming US troop casualties 'fuel' his 'bloodlust for a senseless war'
Former Rep. Marjorie Taylor Greene accused War Secretary Pete Hegseth of "bloodlust" in response to a post Hegseth issued about fallen U.S. service members.
How mental health, environment shape pregnancy sleep
Nearly half of pregnant women in the United States report poor sleep quality, which has been associated with gestational diabetes and high blood pressure during pregnancy. A new study led by researchers ...
Hannah Einbinder on Sex, Blood, and Politics
The actress takes on sexual shame in the bloody, lusty slasher comedy Teenage Sex and Death at Camp Miasma.
Want To Live Longer? Here Are 10 Ways To Manage Your Health And Track Aging
A physician breaks down 10 ways to track your health and biological age, from blood panels to wearables, and what the evidence actually shows.
8 Simple Exercises That Can Help Lower Blood Pressure Naturally
Exercise is one of the most effective ways to reduce your blood pressure naturally, especially if you are consistent and consider your personal limitations.
New AI blood test predicts heart disease 15 years early
A new AI-powered blood test could give people a remarkably early warning of serious heart and circulation problems. Developed by researchers at the University of Hong Kong, CardiOmicScore analyzes thousands of proteins and metabolites to estimate the risk of six major cardiovascular diseases, including heart attack, stroke, heart failure, and atrial fibrillation. Unlike genetic risk scores, which remain fixed throughout life, the system captures biological changes linked to a person’s current health, lifestyle, and environment.
The science of smoke: How Canadian wildfires cloud U.S. skies
Have you been wondering why massive plumes of smoke from Canadian wildfires end up hundreds (or thousands) of miles away, turning our skies milky and the sun blood-red? It’s all about a perfect sto…
The Blood-Brain Barrier Has Been Breached. Is Clinical Trial Science Ready?
FDA's March 2026 approval of AVLAYAH marks the first BBB-crossing biologic — but CNS trial design, PK monitoring, and safety frameworks haven't caught up.
Oklahoma State Didn't Land Drew Mestemaker With Money Alone
Drew Mestemaker could've chased the biggest NIL offer or a college football blue blood. Instead, he followed Eric Morris to Oklahoma State. One quote from Morris—"Don't get caught up in all the hype... and don't break my heart"—shows why relationships still matter in today's transfer portal.
Castlevania: Belmont’s Curse hands-on report
Konami and Evil Empire get the blood pumping with slick combat in classic Castlevania.
Doom Director Addresses The State Of id After Xbox Bloodbath
id Software was hit hard in the latest round of Xbox mass layoffs
‘Children of Blood and Bone’ first-look photos depict Regina King on her throne, Cynthia Erivo ready for battle
First-look photos from the ‘Children of Blood and Bone’ movie show the all-star cast wearing colorful threads on sweeping sets.
Medtronic recalls surgical devices due to risk of blood contamination
Trace amounts of blood were identified within the sealed packaging of these devices. No patients were exposed to the foreign material, and no adverse events were reported, but Medtronic is recalling the devices as a precaution.
SGMC Health Launches Hypertension Clinic to Treat Resistant High Blood Pressure
SGMC Health is expanding its heart care services with the launch of a dedicated Hypertension Clinic, a specialized program within SGMC Cardiology designed to support patients with difficult-to-control high blood pressure.
Priority Health Collaborates With GRAIL as the First Michigan Health Plan to Offer the Galleri® Multi-Cancer Early Detection Blood Test to Employer Plans
/PRNewswire/ -- GRAIL, Inc. (Nasdaq: GRAL), a healthcare company whose mission is to detect cancer early when it can be cured, today announced a collaboration...
A $399 Smart Ring Aims to Replace the 150-Year-Old Blood Pressure Cuff
A three-year-old startup says it has produced a smart ring that can track blood pressure as accurately as a traditional arm cuff and that — eventually — it could be able to make medical diagnoses. If the company, called Vital Signals, can successfully deliver on the promise, it would represent a significant breakthrough in consumer wearables.
UT Health San Antonio study links sleeping long hours with higher levels of an Alzheimer’s-related protein
Findings could signal early neurodegenerative processes at work Contact: Steven Lee, (210) 450-3823, lees22@uthscsa.edu SAN ANTONIO, July 16, 2026 – Regularly sleeping long hours each night is associated with higher levels of an Alzheimer’s-related protein in the blood, even accounting for other health factors, suggests a new study from UT Health San Antonio, the academic […]
Daniel Ek's body-scanning startup Neko Health raises another $700M
Neko Health has developed proprietary body-scanning technology, which it couples with bloodwork, to assess a person's health.
The Duskbloods closed network test set for August 21 to 23
FromSoftware will host a closed network test for player-versus-player-versus-environment-based multiplayer action game The Duskbloods from August 21 to 23, the developer announced (2). Sign-ups wil…
RWJBarnabas Health Urges Community to Donate Blood Amid National Shortage
RWJBarnabas Health is asking the public to donate blood and platelets as New Jersey and the nation faces a growing blood shortage driven by a significant decline in donor turnout and overall collections.
How tiny pollen grains helped solve a brutal murder: The fascinating science behind nature's invisible crime scene evidence
Blood, fingerprints, and weapons aren't the only evidence investigators look for at a crime scene; pollen is another. Pollen grains are one piece of evidence that has helped solve some of the highest-profile murder cases in recent years, one grain at a time.
Baton Rouge General's Health Tip of the Week: Heat waves may double risk of heart attack
Sponsored by Baton Rouge General When the temperature rises, so does the workload on your heart. Hot weather makes your heart pump harder to cool your body, and dehydration thickens your blood, adding even more strain. That can increase the risk of a heart attack, especially if you have heart disease, high blood pressure, diabetes […]
Study shows a blood test can help identify healthy people at high risk for Alzheimer's disease
A blood test that helps diagnose Alzheimer’s might also forecast if healthy older adults will develop symptoms
Study shows a blood test can help identify healthy people at high risk for Alzheimer’s disease
A blood test that helps diagnose Alzheimer's might also forecast if healthy older adults will develop symptoms.
15 things science says about friendship and what it does to your health
From immune function and blood pressure to brain scans and life expectancy, here is what researchers have found about the ways friendship shapes the body
15 things science says about friendship and what it does to your health
From immune function and blood pressure to brain scans and life expectancy, here is what researchers have found about the ways friendship shapes the body
Sam Neill’s Blood Cancer Explained and Last Health Updates Before Death
The family of the “Jurassic Park” star announced his death on Monday, adding that he was still “cancer free” when he died.
'House of the Dragon's Ormund Hightower cooks up a villainous plan that isn't in 'Fire and Blood'
A new challenger for the Iron Throne approaches.
Business Leader Key to Maryland Buying Preakness Rights
When CDI announced in April its purchase of the Preakness' intellectual property rights, Greater Baltimore Committee president and CEO Mark Anthony Thomas felt it important to unite the community in hopes of keeping ownership of the race local.
Scientists discover new blood group, resolving a 50 year medical mystery - Futura-Sciences
Decades of searching for a single molecule Scientists named the missing molecule from the 1972 sample the AnWj antigen. For fifty years, hematologists tried and failed to find the genetic blueprint responsible for it. A research team at NHS Blood and Transplant and the University of Bristol finally found the...
The Steelers Have the Pieces to Contend in the AFC
The Pittsburgh Steelers have undergone a lot of change during the 2026 offseason. While the team has not answered the question of who their franchise quarterback is, they are focused on gearing up for a deep run next year. This will not be easy. The AFC is a bloodbath of a conference, with teams trading […] The post The Steelers Have the Pieces to Contend in the AFC appeared first on The Lead.
Why do mosquitoes bite some people more than others?
Long before they land, mosquitoes are reading our body signals from afar. Find out if you feature high on the bloodsuckers' hit list.
Resuscitated human retinas respond to light 10 hours after death
Perfusing donor human retinas with blood and oxygen meant they continued to respond to light for up to 10 hours after death, marking a significant step towards eye transplants that restore vision
In Medford, politics is a blood sport
The Medford mayor has clashed with unions and employees. The city council wants to know how much all the litigation is costing taxpayers.
Radiologist and Maine health providers ask judge to dismiss couple’s lawsuit
The couple say MaineHealth, Spectrum Healthcare Partners and a radiologist failed to diagnose a blood clot that led Jeffrey Sayward to experience a disabling stroke.
You can complete medieval vampire RPG The Blood of Dawnwalker even quicker than previously thought - before even the prologue ends
The limiting factor will be whether you're good enough to do it, and most of you - most of us - will not be.
New weight loss pill beats oral Ozempic in major trial
A new once-daily weight-loss pill called orforglipron delivered better weight loss and blood sugar improvements than the leading oral semaglutide in a major clinical trial. The tablet could offer a more convenient alternative to injectable drugs like Ozempic and Wegovy because it doesn't require refrigeration or special timing with meals. It's also cheaper to manufacture, which could expand access globally.
After four hours playing The Blood of Dawnwalker, I've seen combat, romance, intrigue - it's got the makings of being 2026's breakout RPG
I've played four hours of the hugely promising The Blood of Dawnwalker now which, if you don't know yet, is the new vam…
Blood Of Dawnwalker Hands-On: A Witcher-Style RPG With A Twist
For Honor-style combat meets Witcher-style storytelling
CaroMont Health Opens CaroMont Hematology & Oncology in Belmont
CaroMont Health has opened CaroMont Hematology & Oncology in Belmont, expanding access to cancer and blood disorder care across the region. Located in the CaroMont Health Medical Pavilion on the campus of CaroMont Regional Medical Center in Belmont, the practice offers physician visits, infusion therapy and laboratory services in one convenient location, along with comprehensive hematology and medical oncology care including chemotherapy, immunotherapy, targeted therapy, hormone therapy and survivorship support. The opening is part of CaroMont Health's $200 million investment in cancer care, the second largest investment in the health system's history, which will double its oncology capacity across the region.
County Health Officials Report First Locally Acquired Chagas Case
County health officials have confirmed the region’s first locally acquired case of Chagas disease, identified during routine blood donation screening in a donor without symptoms.
World Of Warcraft Plague Kills Players, Makes Infected Spread Nasty Green Goo
World Of Warcraft's 'Corrupted Blood Incident 2.0' resulted in the game getting even more toxic than usual
'House of the Dragon' pulls a Daeron Targaryen switcheroo that isn't in 'Fire and Blood'
Will the real Daeron please stand up?
Rhaenyra's nasty rat banquet in 'House of the Dragon' isn't even in 'Fire and Blood'
When you visit House Targaryen, maybe don't stay for dinner.
'Minions & Monsters' knocks out 'Toy Story 5' out in animated brawl at Fourth of July box office
It was an animated blood bath at the box office this weekend, and though 'Minions & Monsters' bested 'Toy Story 5,' its $36.4 million premiere marks a franchise low by a wide margin.
Millions may be getting the wrong cholesterol test
A new study suggests that apoB, a blood test that measures harmful cholesterol particles, is better than standard LDL cholesterol testing for deciding who needs more intensive treatment. Researchers found it could prevent more heart attacks and strokes while remaining cost-effective for the U.S. healthcare system.
Why Circulation Health Supplements Are Gaining Attention for Supporting Healthy Vascular Function and Everyday Wellness, According to PureHealth Research
PureHealth Research is highlighting growing consumer interest in circulation wellness and the role of targeted nutritional supplementation in maintaining healthy blood flow, vascular function, and overall cardiovascular wellness.Circulation health supplements commonly feature ingredients such as Omega-3 Fatty Acids, Berberine and Butcher's Broom, which are frequently included in formulations designed to promote healthy circulation and vascular health.
The secret to healthy aging may be hidden in your blood
Some people live past 100 with remarkable health, and researchers may have uncovered one reason why. A new study found that centenarians have a unique chemical "fingerprint" in their blood that sets them apart from normal aging, including unusual patterns of bile acids and steroids linked to longer survival.
The secret to healthy aging may be hidden in your blood
Some people live past 100 with remarkable health, and researchers may have uncovered one reason why. A new study found that centenarians have a unique chemical "fingerprint" in their blood that sets them apart from normal aging, including unusual patterns of bile acids and steroids linked to longer survival.
Digital diabetes tool shown to improve patient care and cut health care costs
A new study by University of Manchester researchers has linked a digital platform helping people manage type 2 diabetes to better blood sugar control, improved health and potential long-term NHS cost ...
The real cause of a common stroke may have been missed for decades
Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.
Over-40s with obesity have normal-BMI cholesterol and blood pressure levels, study finds
Success of statins and blood-pressure drugs hailed as researchers find some people with obesity were ‘better off’
Samsung will remove Vascular Load feature from Galaxy Watches in the US
Samsung is planning to remove the expermiental Vascular Load feature from Galaxy Watches in the US and introduce Blood Pressure Trend.
Statins and blood pressure drugs changing health risks of obesity, study suggests
New research shows obesity patients over 40 are managing blood pressure and cholesterol as well as healthy-weight peers, but younger adults remain at risk.
Brand New The Blood of Dawnwalker Gameplay Showcases Coen’s Investigation Skills and a Boss Battle Against the Eerie Forgotten Guardian
See Coen's investigation and fighting skills on full display in this quest gameplay from The Blood of Dawnwalker.
If we lose our coverage, we lose our lives
By Thomas Buckley My oncologist asked: “Polycythemia Vera. Do you know what that means?” Earlier, I lived in blissful ignorance, unaware I potentially carried a myeloproliferative neoplasm encoded within my DNA. “Yes,” I answered, “A rare form of blood cancer, incurable, not necessarily fatal, provided it’s treated.” At 31, I thought I had life figured […]
8 Fruits That Fight Inflammation and Support Gut Health
Plus an expert shares the one tip to help prevent blood sugar spikes.
If you’re at risk of Alzheimer’s, these dietary habits can help, study finds
Research suggests diet remains a relevant factor for brain health even after blood markers of dementia are present.
There's a Waterfall in Antarctica That Bleeds Red – Here's What's Hiding Inside It
Antarctica's Blood Falls are even weirder than they look.
Scientists cured sickle cell. Then their next challenge began.
Gene editing has delivered remarkable results against sickle cell disease. Now researchers are working to make these personalized treatments faster, cheaper, and available to far more patients.
'House of the Dragon' leaves out a key detail about Rhaenyra and the Iron Throne from 'Fire and Blood'
No slicing and dicing for Rhaenyra today.
Office Politics Has A Playbook. Here Is What Psychologists Know.
Office politics is a blood sport and the most talented people keep losing. Psychologists say three traits separate the winners from everyone else.
The fittest founder in the room got cancer. Here's how he used AI to fight back.
When confronted with cancer, Connor Christou fed everything tied tied to his regime — blood results, scan data, wearable output, journal entries — into Claude.
New vitamin B12 therapy shows promise against deadly brain cancer
Researchers have identified a vitamin B12–based compound that can cross the blood-brain barrier and home in on glioblastoma tumors. In animal studies, the compound accumulated preferentially in tumor tissue and delivered sustained nitric oxide directly to cancer cells. It also worked synergistically with existing glioblastoma treatments, significantly enhancing their tumor-fighting effects.
Meet ‘Pepper’ Baumer, The Man With Hot Sauce In His Blood
Hot sauce has been one of the hottest sectors of the food industry and third-generation owner ‘Pepper’ Baumer has built Crystal, his family’s century-old business, into a $50 million Southern staple.
PlayStation Is Deleting Terminator 2 And 550 Other Movies
Movies like Rambo: First Blood, Bridget Jones' Diary and The Deer Hunter are all being unceremoniously removed
Walton Arts Center to host blood drive with free entertainment July 1
The Walton Arts Center will host a blood drive in partnership with the American Red Cross from 10 a.m. until 4 p.m. on Wednesday, July 1. The center will provide live entertainment for blood donors in attendance that day, including performances by cellist Carrington Truehart, and guitarists Ben Harris and William Reyes. SUBSCRIBE: Get our
Medical miracles that changed how we treat disease
We've come a long way since \
David Clayton-Thomas, Blood, Sweat and Tears singer, dies at 84
David Clayton-Thomas, best known as the lead singer of the Grammy-winning jazz rock group Blood, Sweat & Tears, has died. He was 84.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Alex Freeman Headlines Kids Of Former NFL Players Making Their Names In Other Sports
Team USA's Alex Freeman is leading the charge of breakout athletes across sports with NFL bloodlines.
Joe Manganiello reveals secret health battle, 'live-saving' organ removal
Joe Manganiello details a previously unknown health ordeal that required a "life-saving" organ amputation in his upcoming memoir "Bloodlines."
Circulating metabolites at the crossroads of lifestyle and brain health
Nature Aging - Circulating metabolites might provide early insights into brain aging before clinical symptoms appear. Ahmad and colleagues show that specific blood metabolites in midlife are...
FDA drops enforcement against Whoop after it tweaks blood pressure feature
The FDA told wearable maker Whoop last week that it would not take further enforcement action over the company's blood pressure feature.
Health Beat: Parasitic fly outbreak prompts Pa. to restrict animal movement
New World Screwworm is a parasitic fly that feeds on the flesh of warm-blooded animals and people and then can lay eggs in the wounds.
'True Blood' star Joe Manganiello shares secret multi-year health battle, organ removal
Manganiello is detailing his journey in his memoir, "Bloodlines," out October 13.
Data Is the New Blood Test: Who Owns It, Who Profits, Who Protects It?
Health data can drive better care, but patients must first be able to trust who controls it — and understand why it is being used.
God of War Laufey Star Deborah Ann Woll Breaks Silence on a Massive 10-Year Secret: “I Still Pinch Myself”
Renowned actress Deborah Ann Woll, best known as Jessica Hamby in True Blood and Karen Page in Daredevil, has spoken with CGMagazine about her lead role in God of War Laufey as the titular character. In an interview conducted during Game Con Canada, Woll confirmed what Game Director Ariel Lawrence had revealed earlier this month: Head of Creative Cory Barlog had this game in mind even before the launch of God of War 2018, and there was already a poster featuring Laufey and Phranque (the cosmic cube). Related Story Unlocking the Snapdragon 8 Elite Gen 6 Pro’s Real Performance Will […]
Honorees brought science-based blood pressure care home to communities in need
Organizers of “Team Up to Take Down High Blood Pressure” in Philadelphia say collaboration has been crucial to the initiative’s success.
Aemond and Alicent's uncomfortable 'House of the Dragon' kiss isn't even in 'Fire and Blood'
Anyone order more incest?
6 Canned Foods to Eat to Lower Blood Pressure, According to Dietitians
Canned foods are less expensive than fresh produce and can help you eat more fruits and veggies, which can help lower blood pressure.
Sean Payton says Broncos history is the franchise’s ‘lifeblood’
Sean Payton believes Broncos history and tradition remain the franchise’s lifeblood and part of building culture.
Hoops for Health first public event for the WOW vehicle
Wellness on Wheels, the 34-foot mobile health unit that was first unveiled earlier this month, provided free prostate cancer screenings, blood pressure checks, health education and information on county health programs.
6 Foods To Help Lower Blood Pressure Besides Pomegranate Juice
Pomegranate juice is known to help with hypertension, a condition affecting about half of adults in the U.S. These everyday foods can help too.
The hottest new rock star is the Vampire Lestat — with help from Bowie, Iggy and Freddie
The sound, the look, the swagger: The three steps that vaulted Anne Rice's seductive bloodsucker from 'Interview With the Vampire' to the top of the mosh pit.
EA Sports UFC 6: Seven fighters you have to try out to get the full 'as real as it gets' experience
Picking up EA Sports UFC 6 on release day? Make sure you check out some of the game's best shining stars and hidden gems.
Known Agenda Sold To Stand In Uruguay
Known Agenda, a Grade 1 winner and young sire, has been sold to continue his stud career at Haras La Peregrina in Maldonado, Uruguay, BloodHorse reports. The 8-year-old son of Curlin leaves Spendthrift Farm in Kentucky, where he began his stud career in 2022. Known Agenda's first foals are ...
Defense Health Agency Outlines Joint Force Blood Therapy Strategy at National Forum
Medical logistics and prolonged field care in austere environments present significant challenges for the military health system. To address potential Large-Scale Combat Operations in remote locations across the globe, Defense Health Agency experts presented a strategy update for novel blood replacement therapies during the Strategic National Forum on Blood and Biotherapies, June 12, 2026, in Bethesda, Maryland.