SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " bmi " 635 found 🔀 AI-powered Shuffle
'Tush push' safe for 2026 as submitted NFL rule proposals do not include controversial play
This won't end the debate, but the NFL owners will not discuss the play when they meet next week.
World Business Chicago collects submissions for bold plans for city's future
NFL rule changes 2026: Competition committees submits five proposals
The NFL's competition committee proposed five rule changes for 2026, including adjustments to onside kicks and a referee contingency.
Fayetteville Community’s Choice Awards business spotlight: Woods Plumbing
We're in the final stretch! Ready to recognize your favorite local businesses? Submit your Fayetteville Community’s Choice Awards nominations today.
SouthCoast Community’s Choice Awards business spotlight: Anchor Animal Hospital
We're in the final stretch! Ready to recognize your favorite local businesses? Submit your SouthCoast Community’s Choice Awards nominations today.
24-year-old killed after shooting outside Last Call Sports Bar
24-year-old killed after shooting outside Last Call Sports Bar
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
Refund checks coming for former Boston Sports Club members, AG says
Former members of Boston Sports Clubs in Massachusetts may be eligible for a refund if they were wrongfully charged by the company during the COVID-19 pandemic.
The mental health effects of gun violence near schools
Dr. Scott Hadland from Mass. General Brigham discusses new data that shows the amount of shootings near schools is trending downwards.
New dispute emerges around Subnautica 2’s early access release
Lawyers for the ousted—and now partially reinstated—leadership team of Unknown Worlds, the studio behind Subnautica 2, are crying foul over news that the game will be released into early access in May. The release announcement earlier this week was made improperly, potentially “damaging the game and sowing additional confusion among the Subnautica community,” the lawyers said in a letter sent on Tuesday to Vice Chancellor Lori Will of Delaware’s Court of Chancery. In their letter, the lawyers also floated the idea of asking Will to find Krafton in contempt of the court’s ruling. The letter was sent just one day after Will’s bombshell ruling that publisher Krafton had breached its contract with Unknown Worlds’ executive team, when it fired them last June. The new issue isn’t necessarily the May early access timeframe, but how the news was announced. The letter and Krafton’s response have not been previously reported. A quick recap of prior events: Subnautica 2 is an unreleased, underwater survival adventure and the most-wishlisted game on Steam. Last year, longtime Unknown Worlds CEO Ted Gill, along with studio co-founders Charlie Cleveland and Max McGuire, were fired by Krafton. They swiftly sued, saying the publisher had terminated them to avoid paying out up to $250 million in potential performance-based bonuses. The studio leaders had hoped to earn that with an early access release of the game, which Krafton had blocked. The publisher argued in court that Subnautica 2 wasn’t ready, which the ousted execs disputed. On Monday, Will ruled that Krafton had violated its contract, firing the execs to avoid the performance payouts, and that it had to reinstate Gill and give him full authority over any early access release for Subnautica 2. On Tuesday, IGN reported on a new memo issued that day to Unknown Worlds staff by Steve Papoutsis, the executive Krafton had put in charge of Unknown Worlds after the 2025 firings. In the note, Papoutsis said that Subnautica 2 had passed a key development milestone “last week” and that he and Krafton had determined the game “is ready for Early Access release in May.” This news appeared to catch the lawyers for Gill, Cleveland and McGuire by surprise. On Tuesday night, they sent a letter to Will expressing “serious concerns” about whether it would be possible to forge an agreement with Krafton consistent with the judge’s order. Papoutsis’ memo was a problem, they wrote. He didn’t have the authority to declare anything about Subnautica 2’s release. As of 9am ET on Monday, March 16, the effective date of Will’s order, Papoutsis wasn’t CEO of Unknown Worlds. Gill was. And, per Will’s order, only Gill could make Subnautica 2 release decisions. They continued: Krafton self-servingly announced the launch without any regard to its impact on the game, the team, or the community—let alone this Court’s Opinion. Announcing the release of a game is momentous, and it is typically accompanied by significant marketing activity, fanfare, and community coordination. And most importantly, the announcement is carefully designed to maximize excitement for the game. That entire process was supposed to be driven by Mr. Gill. However, in defiance of the Court’s Opinion, Krafton has now taken that away, further damaging the game and sowing additional confusion among the Subnautica community. The lawyers speculated that Krafton had “intentionally leaked” Papoutsis’ memo and then issued an official statement to confirm the leak. Game File is a reader-supported publication. My reporting is only possible through support from readers like you. To support my work, consider becoming a free or paid subscriber. Subscribe On Wednesday, lawyers for Krafton defended their client in their own letter to vice chancellor Will, saying nothing they did violated her order nor showed contempt: Papoutsis’s message was simply celebrating the UW employees’ efforts toward a past event: Krafton’s pre-Opinion determination that Subnautica 2 was ready for Early Access release. There was nothing improper about conveying the results of the milestone review or thanking the development team for their dedication and talent. They added that Gill could still make his own call about Subnautica 2’s release: In his role as CEO, Gill will be able to assess independently his views on the state of Subnautica 2 and the appropriate release schedule; nothing in Papoutsis’s message alters Gill’s authority or discretion. Vice chancellor Will has not responded to the letters and doesn’t necessarily have to. Both parties were previously ordered by Will to confer this week and submit a proposed judgment consistent with her ruling. The letter from Gill’s attorney’s this week doesn’t indicate whether he would or would not support a May release for Subnautica 2. But it could limit his options. And, if Gill’s lawyers are right, the lack of marketing fanfare around the leak of the May date could dull the launch of the game. Any harm to Subnautica 2’s launch is an extra sensitive issue given the context of the legal dispute: millions of dollars of payouts are on the line, tethered to the scale of the game’s initial performance. In her ruling on Monday, Will noted that there was obvious “bad blood” between Gill’s side and Krafton but that the two would need to work together: “They can—and must—act in good faith to navigate their remaining contractual relationship.” Item 2: A new kind of couch co-op game A highlight of GDC each year is the Alt.Ctrl showcase that features games played with extremely experimental controllers. Perusing this year’s offerings last Friday, I found a game controlled with giant scissors, another with big toothbrushes and one that amounted to dumpster diving. My favorite was Pivot, a co-op game about collectively maneuvering a couch. It was developed by students at the University of Utah’s masters of arts and engineering games program. Players lift and tilt the physical couch in order to control the position of a virtual one. That virtual one is moving through an obstacle course on-screen, while being pursued by a giant skull. Developer Nishant Verma told me at GDC that the couch is made of styrofoam (this became more evident as I watched!) and that the name was a riff on an episode of the sitcom Friends. Item 3: In brief… 🚫 Ubisoft is laying off more than 100 workers at its Red Storm studio, as the North Carolina location known for decades for its Tom Clancy games, ceases in-house game development, VGC reports. 👀 On Monday, Nvidia’s revealed its DLSS 5 AI-driven graphics technology that purports to improve game graphics… and it has been roasted about it by the media and the online gaming public for the remainder of the week. The tech changed the faces of characters in footage from Resident Evil Requiem, Hogwarts Legacy and EA Sports FC, drawing accusations of giving carefully art-directed games the generic look of AI “slop.” Nvidia CEO Jensen Huang had said on Monday that “DLSS 5 is the GPT moment for graphics—blending handcrafted rendering with generative AI to deliver a dramatic leap in visual realism while preserving the control artists need for creative expression.” By mid-week, Huang was telling Tom’s Hardware that the new tech’s critics were “completely wrong” because game-makers could still “fine-tune the generative AI” to suit their game’s aesthetics.
Opinion: The Midwest is chasing the wrong innovation strategy
Rather than building capital density at home, Midwestern research universities have chosen physical proximity to the dominant ecosystem. Here's why that may be a mistake.
Smack talk takes center stage at this open mic for amateur wrestlers
NAW or Never: Smack Talk Open Mic is a place where wrestlers work out their character muscles, polish their submission holds and perfect their trash-talking chops.
Bangladesh sports minister to consult ICC on future of BCB
Sports minister Aminul Haque said on Tuesday that once the five-member committee submits its report within 15 working days, he will discuss the matter with the ICC | ESPN.com
Extra Belly Fat, Not BMI, Is a Better Predictor of Heart Problems, Study Finds
Extra belly fat and waist size may be more strongly associated with heart failure risk than BMI, new research finds.
Two local developers in mix for I-95 service area redevelopment
Two local developers have submitted proposals to transform the two liquor stores off Interstate 95 in Hampton into service areas after the process was put in place by Gov. Kelly
GREDF seeks proposals for managing Quincy Regional Sports Complex
The Great River Economic Development Foundation is seeking qualified firms to submit a Request for Qualifications (RFQ) for management, operations, and maintenance services for the Quincy Regional Sports Complex.
Indo-Pacific Energy Security Ministerial and Business Forum - U.S. Embassy & Consulates in Japan
Global Issues Indo-Pacific Energy Security Ministerial and Business Forum The Indo-Pacific Energy Security Ministerial and Business Forum will take place March 14-15, 2026 in Tokyo. IPEM is a premier, high-level platform for announcing and advancing energy deals, partnerships and investments that strengthen regional integration and secure critical supply chains across the Indo-Pacific. IPEM is co-hosted by the Ministry of Economy, Trade and Industry of Japan and the National Energy Dominance Council of the United States. It is sponsored by the U.S. Trade and Development Agency in partnership with the U.S. Departments of State, Interior, Energy, and Commerce, as well as the Export-Import Bank of the United States (EXIM) and the U.S. International Development Finance Corporation (DFC). IPEM Forum main page Mission Japan Press Release Feb. 24, 2026 Announcement from the Department of Energy Submit your proposal to join senior government leaders and industry executives shaping the future of global energy security.
FOX Business launches 'Made in America' small business contest with $25K cash prizes for winners
FOX Business launched a contest that awards $25,000 to three small businesses. Apply at SmallBusinessAwards2026.com with video or written entry submission.
Century Therapeutics Reports Full Year 2025 Financial Results and Business Updates
CNTY-813, lead beta islet cell therapy program as a potential functional cure for type 1 diabetes, in Investigational New Drug (IND)-enabling studies; IND submission expected in 4Q 2026 to support anticipated initial clinical data in 2H 2027CNTY-308, a CD19-targeted CAR-iT cell therapy engineered with Allo-Evasion™ 5.0, on track to enter the clinic in 2026Strengthened balance sheet and cash runway extended into 1Q 2029 from oversubscribed $135 million private placement in January 2026 PHILADELPH
'Montana Plan' to prohibit corporate spending in politics green lit for signature gathering
After constitutional measure was found legally deficient, group submitted statutory initiative instead
CVS Health’s Aetna to Pay $117.7 Million to Resolve False Claims Act Allegations
Aetna was accused of submitting false patient diagnosis data for its Medicare Advantage Plan enrollees in order to get higher monthly payments from the Centers for Medicare and Medicaid Services.
Ballad Health leader to challenge state Rep. David Hawk in GOP primary
GREENEVILLE, Tenn. (WJHL) — A Ballad Health leader is looking to unseat longtime Greene County state Rep. David Hawk in the August Republican primary. Tammy Albright submitted a petition to run for…
Variety and Gold House 8 Up Next in Entertainment Submissions 2026
Variety and Gold House has announced that submissions are open for the third annual 8 API Up Next in Entertainment List for 2026.
Readers respond: Trump administration assaults science, health care
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
Readers respond: Trump administration assaults science, health care
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
Readers respond: Medicare’s broken system for home health care
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
What's the big idea? If you've got it, World Business Chicago wants to know
The organization is calling for architects, designers, neighborhood groups, artists, innovators and interdisciplinary teams to submit visionary ideas that explore what Chicago could look like in 2050.
Greenville businesses benefit from SEC women's tournament influx
The SEC women's basketball tournament in Greenville is boosting local businesses, with a projected $20.8 million impact and thousands of fans visiting the city.
AI is prepared to commit science fraud, research finds
ArXiv, a repository for pre-peer-reviewed papers, has been “overwhelmed” with submissions since the rise of LLMs.
Prime Medicine Reports Full Year 2025 Financial Results and Provides Business Updates
-- On track to file IND and/or CTA for Wilson Disease and AATD programs in 1H 2026 and mid-2026, respectively; initial clinical data for both expected in 2027 -- -- Ongoing engagement with FDA for PM359 in CGD; plan to submit BLA following final alignment -- -- Prime Medicine reported cash, cash equivalents, investments, and restricted cash of $191M providing cash runway into 2027 -- CAMBRIDGE, Mass., March 03, 2026 (GLOBE NEWSWIRE) -- Prime Medicine, Inc. (Nasdaq: PRME), a biotechnology company
A New Rookie on Vikings’ Radar
At the NFL Combine, reports rolled in that the Minnesota Vikings had met with Nebraska running back Emmett Johnson, which […]
Holland & Knight Health Dose: March 3, 2026 | Insights
The U.S. House of Representatives Committee on Appropriations can submit requests for community project funding or "earmarks" as part of the LHHS appropriations bill.
AHCA/NCAL Submits Comments on Health Information Interoperability Proposed Rule
AHCA/NCAL submitted comments recently to the Assistant Secretary for Technology Policy and the Office of the National Coordinator for Health Information Technology (ASTP/ONC) within the U.S. Department of Health and Human Services (HHS) in response to ...
CMS set to suspend enrollment in Elevance Health's Medicare Advantage plans
The Trump administration has threatened to sanction Elevance Health's Medicare Advantage plans if the insurer does not address concerns around compliance with requirements for submitting risk adjus | The Trump administration has threatened to sanction Elevance Health's Medicare Advantage plans if the insurer does not address compliance concerns regarding the submission of risk adjustment data.
Submission Period Now Open for the 2026 Eric and Wendy Schmidt Awards for Excellence in Science Communications; $640,000 To Be Awarded
Submissions are now being accepted for the 2026 Eric and Wendy Schmidt Awards for Excellence in Science Communications. The awards honor exceptional science communicators, science journalists, and research scientists who have developed creative, original work that addresses issues and advances in science, engineering, and medicine for the general public.
Tiny Public Assembly Theatre stages 3 new 12-minute plays a month
The tiny Public Assembly theater company is taking community theater to the next level by developing and performing three one-act plays per month. Seeing a show is the only prerequisite to submitting, and you might be surprised by the Hollywood star power that shows up.
Modern Parenting Means Apps for Sports, School and More. Where Is the Data Going?
For every aspect of a student’s life, there’s a tech company trying to digitize it. Inside the classroom, online tools proctor exams, create flashcards and submit assignments. Outside, technology coor...
Republican responds: neighbors before politics
To the editor, I read with great interest and compassion the recent letter from a neighbor, Emily Shapiro, who submitted “Is it too late to know thy neighbor?” in the Riverdale Press’s …
Vanderbilt Health Pets of the Day: Momo and Smokey
Today’s first Dog of the Day is Momo, submitted by Ginger DeBellis of the Vanderbilt Vaccine Center. “Momo is a sweet and super smart blue merle Australian shepard who loves learning new tricks, neighbor watching and snuggles.“ Today’s second Dog of the Day is Smokey, submitted by Haley Villacorta of Population Health. “Smokey is a Pomsky (Pomeranian and Siberian husky mix).” Pets of the Day — what you need to know The Vanderbilt Health Pets of the Day are included in regular editions of the MyVUMC News newsletter, which is posted twice a week by Vanderbilt Health News and Communications. The pets are selected from the hundreds of entries sent to the Voice Pet Photo Contest. For those who submitted a photo to that contest, watch MyVUMC News for Pets of the Day, and in addition, regular collections of pet photos are posted to the Voice site. You can see them all here: https://news.vumc.org/section/voice/pets-vumc/. If you have a pet you would like to nominate for Pet of the Day, the next Pet Photo Contest submission period is coming up later this year, and will be announced in MyVUMC News. Momo and Smokey were featured in the March 3, 2026, edition of MyVUMC News.
Health officials confirm 2 measles cases linked to Mass.
The cases are the first two with ties to the state this year, but they come amid a large national outbreak.
My doctor keeps focusing on my weight. What other health metrics matter more?
Our Real Talk with a Doc columnist explains how to push back if your doctor's obsessed with weight loss. And what other health metrics matter more instead.
Readers respond: Give Lloyd Center a destination sports complex
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
BMI Duo The Flinns Are The Featured Entertainment at the Texas Restaurant Association Annual Spring Board Meeting
BMI singer/songwriters The Flinns were the featured
NFL receives no tush push ban proposal this year after effort to ban it failed
League executive Troy Vincent told reporters at the scouting combine in Indianapolis that the deadline for submissions has passed.
More doctors voice concerns over Confluence Health cancer center
WENATCHEE — Two different open letters submitted by Confluence Health physicians and former leaders continue to raise concerns about the health system's planned cancer center.
Ted Sarandos Responds to Trump Telling Netflix to Fire Susan Rice: “It’s Not a Political Deal”
The Netflix co-CEO also touted his deal for Warner Bros. ahead of a Monday deadline for rival bidder Paramount to submit a "best and final" offer for the Hollywood studio.
Readers respond: Shift city money for students, not sports
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
Player Availability Report: #SJvSKC | Feb. 21, 2026
Player Availability Report is SportingKC.com’s look at the latest status updates around the team ahead of upcoming matches and is presented by Saint Luke’s. All details listed are from the league’s official Player Status Report that is submitted the day prior to the match. Sporting Kansas City opens the 2026
Your Halo Story: Chapter 2
We asked for your Halo memories, and you shared stories of triumph, tribulation, and truly sweet sticks. This chapter of Your Halo Story features 50 fan submissions from the annals of Halo history, with many more to come!
Hegseth invited Christian nationalist Doug Wilson to preach at Pentagon
The self-described “paleo-Confederate” has argued that wives should submit to their husbands, women should be denied the vote and Christian slaveowners were on “firm scriptural ground.”
Student input called upon to name the new Science and Health Sciences Building
UW-Eau Claire is in search of student input for the name of its new Science and Health Sciences Building. In an email via the dean of students two weeks ago, Student Body President Kaitlyn Hevrin, a fourth-year neuroscience student, urged students to submit name ideas for the Science and Health Sciences Building. There was an...
Scientists make game-changing breakthrough in pursuit of near-limitless energy source: 'It helps accelerate'
"They already understand key behaviors."
Readers respond: Help all business, not just Blazers
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
A consequential presidential debate, and a years-long investigation (Politics+) : The NPR Politics Podcast
In today's bonus episode, Claudia Grisales (congressional correspondent) and Barbara Sprunt (congressional correspondent) each share the "most" memorable story they've worked on. Barbara talks about being in the "press pool" at a pivotal moment in the 2024 presidential election, the Biden-Trump debate in Atlanta. Claudia talks about an investigative project she worked on for years that helped expose systemic corruption at the largest member-owned electric utility in the country. Listen to find out how you can submit a most-type question for us to answer in a future bonus episode! To unlock this and other bonus content, and get sponsor-free listening, sign up for NPR Politics Podcast+ via Apple Podcasts or at plus.npr.org. Regular episodes haven't changed and remain available every weekday!
Spring sports physicals for grades 7-12
All student-athletes interested in trying out for a spring sport must have an up-to-date physical submitted to FinalForms in advance of the March 9 start to the season for high school sports and in advance of the March 23 start to the season for modified sports. Families are encouraged to schedule a visit with their child's provider to secure a completed physical form. If this is not possible, the district physician will offer sports physicals at Albany High School, William S. Hackett Middle School, North Albany Middle School and Stephen and Harriet Myers Middle School. The schedule is outlined below. No appointment is necessary. If you have any questions or need additional assistance, please contact the Athletics Office at (518) 475-6310. Let's go Falcons! Sports physicals schedule: Albany High March 4 10:30 a.m. Room 1130 Albany High March 5 10:30 a.m. Room 1130 Myers March 17 10:30 a.m. Health Office Hackett March 18 10:30 a.m. Health Office North Albany March 19 10:30 a.m. Health Office
Business Tax Certificate Payment Due Soon
The deadline to submit and pay your business license tax is fast approaching. February 28 is the final due date for Renewals after that date will be subject to a 20% per month penalty. The City of Culver City has partnered with HdL Companies. We established a Business Support Center. Our efforts streamline processing of new business license applica...
Students, faculty mystified as NSF turns back applications for prestigious fellowship program
Applicants to a prestigious National Science Foundation fellowship program say many submissions have been mysteriously “returned without review.”
Improving Brain Health: Expert says exercise routine can cut dementia risk
Mass. doctor stresses important connection between a healthy heart and a sharp brain.
Entertainment Update Feb. 11-18
Entertainment Update is a listing of live events happening in our communities. Submit entries to seana@gorgenews.com. Entries are published as space permits. A full events listing is available at columbiagorgenews.com.
Discord will soon require face scans or ID for all users, or restrict access
Discord has announced that all users will soon be required to submit age verification, or be given teen-level access restrictions.
Vote for UT Health San Antonio in the 2026 YourSA SAEN Readers’ Choice Awards - UT Health San Antonio
Voting for the 2026 YourSA San Antonio Express-News’ Readers’ Choice Awards begins Monday, Feb. 9. Voters can submit their votes once a day, every day through 11:59 p.m. CST Sunday, Feb. 22, to help UT Health San Antonio practices retain their top spots as the best in San Antonio. Each year, the YourSA San Antonio Express-News’ Readers’ […]
Submit an abstract for the Social Science Research Symposium | CWRU Newsroom | Case Western Reserve University
Case Western Reserve University’s Department of Anthropology will host its first Social Science Symposium, which will highlight social science resea...
Revealed: The new Defiler stomps onto the battlefield
Wield six legs of absolute devastation on the battlefield.
NBC Sports names former Reds player Joey Votto as commentator for 2026 MLB season
It's now official: Former Reds player Joey Votto is set to join NBC Sports as a commentator for the 2026 MLB season.
Move over, MacBook: The new Dell XPS 14 is now the longest-lasting laptop we’ve ever tested
Intel wasn't just boasting!
International science cooperation must go on, say research leaders
Science leaders in Europe and Canada say international cooperation must go on amid geopolitical turmoil. At the same time, Europe and like-minded countries should continue to enhance and diversify international partnerships, a Science|Business conference hears. Hugh Brady, president of Imperial College London, told delegates that Europe’s response to the current geopolitical climate should be to “diversify in terms of research partnerships and build resilience and scale into our own system.”A first priority should be for the EU to sort out the scope of the upcoming European Competitiveness Fund and ensure that, together with the next iteration of Horizon Europe, it can drive the development and scale up of new technologies. The EU and the countries associated to the Horizon Europe programme represent “the world's most successful research innovation ecosystem,” Brady said. In order to mitigate the negative effects of shifting geopolitics, the EU together with the UK, Switzerland, Canada, South Korea and others should talk about “building resilience” and address their own “regional needs,” he added. Responding to TrumpUnder Donald Trump’s leadership, the US government has slashed science budgets and shut down international research programmes. Nearly 8,000 grants at the National Institutes of Health and the National Science Foundation have been frozen or terminated. Courts have overturned most of these cancellations, but the disruption caused remains significant. While Europe may persuade a few thousand disgruntled scientists to move across the ocean to work on topics that have been de-funded in the US, it’s unclear what should happen next with transatlantic scientific cooperation more broadly.“Now is the time for us to show [US researchers] our support as much as we can,” Brady said.The European Research Council (ERC), the EU’s basic science funder, has seen a surge in applicants from the US. According its latest data, US-based researchers submitted 347 proposals to the last three big funding rounds, up from 158 in the previous set of calls. The European Commission has also launched a €22.5 million pilot call in 2025 for the Marie Skłodowska Curie Actions, the EU’s researcher training scheme. It plans to extend this support with a €51.25 million call in 2027 as part of the Choose Europe initiative, which is intended to make the continent a more attractive place to pursue a career in research. Related articlesData corner: US researchers are choosing EuropeEU-India deal highlights growing alignment on technology policyMeanwhile, in the private non-profit sector, the Volkswagen Foundation is experimenting with a new type of grant that would allow US researchers to split their time between the US and Germany. While these schemes are useful, Europe should not bet on an exodus of scientists from the US. “The idea that we might all see them flocking over to Europe is naïve and counterproductive,” said Maria Leptin, president of the ERC, also speaking at the Science|Business conference on February 5. “We need research in the US to be as healthy as possible. I really admire those who are staying there with a will to fight and an optimism that the world will turn into a better place again,” Leptin said. Preserving dataDespite political disruption, academics have found ways to continue cooperating and sharing research data. Leslie Weir, president of the International Federation of Library Associations and Institutions and Canada’s national librarian, said the US cuts have raised concerns about research data security, after ideologically sensitive databases were limited or deleted by the Trump administration. But international organisations teamed up to ensure that the data is not lost. “It's interesting to see that researchers and libraries across North America are collaborating to make sure that data at risk is duplicated elsewhere outside [the US],” Weir said.
Ricky Martin issues public statement to Bad Bunny after Grammys: 'I know how heavy it is'
Ricky Martin has all the feels about Bad Bunny's historic night at the Grammy Awards on Sunday — and he's letting the world know in an open letter to his fellow Puerto Rican singer.
Toy Association Advocates for Science-Based Approach to California Microplastics Review
On January 30, The Toy Association™ submitted comments to the California Department of Toxic Substances Control (DTSC) in response to the agency’s request for information regarding consumer products that contain or generate microplastics, including c
State Department announces no citizen initiatives made 2026 ballot; pot campaign says that's premature
Smart & Safe Florida says enough signatures were submitted and verified in county offices before a Sunday deadline.
Readers respond: Bipartisanship not holding Legislature back on health care
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
Food and football from the campaign trail (Politics+) : The NPR Politics Podcast
In today's bonus episode, Don Gonyea (national political correspondent) and Deepa Shivaram (White House correspondent) each share the "most" fun politics story they've worked on. Deepa talks about working on her "dream" assignment during the 2024 presidential race. Don recalls a reporting trip during the 2012 presidential campaign where he ended up at a high school football game. He says it was "one of the best nights of his life." Listen to find out how you can submit a most-type question for us to answer in a future bonus episode! To unlock this and other bonus content, and get sponsor-free listening, sign up for NPR Politics Podcast+ via Apple Podcasts or at plus.npr.org. Regular episodes haven't changed and remain available every weekday!
UFC 325 Highlights! Salkilld Shines Again With Dominant Submission Win
Quillan Salkilld kept the hype train rolling earlier tonight (Sat., Jan. 31, 2026) at UFC 325 LIVE on Paramount+ from inside Qudos Bank Arena in Sydney, Australia, pushing his UFC record to 4-0 with a first-round submission (rear-naked choke) over battle-tested lightweight veteran Jamie Mullarkey. As expected, Salkilld was a large favorite heading into this […]
UFC 325 Highlights! Micallef Sleeps Elliott With Comeback Choke
Jonathan Micallef pushed his Octagon record to 2-0 earlier tonight (Sat., Jan. 31, 2026) at UFC 325 LIVE on Paramount+ from inside Qudos Bank Arena in Sydney, Australia, stopping welterweight Oban Elliott with a comeback second-round submission (rear-naked choke). Elliott, who came into Saturday as a betting underdog, was out for blood from the opening […]
'Very unfortunate': Fort Pierce Downtown business owners upgrade security after recent burglaries
Two Downtown Fort Pierce businesses were burglarized early Tuesday morning, prompting police to search for suspects and business owners to upgrade security.
Joint Commission partners with STS, ACC on new cardiac care certification
The new certification is intended to focus on the importance of high-quality care and real-world patient outcomes. It will be based on the same data care teams already submit if they participate in the STS Adult Cardiac Surgery Database, ACC CathPCI Registry or STS/ACC TVT Registry.
MIRA head Liz Sweet looks to business community for immigrant support
The executive director of the Massachusetts Immigrant & Refugee Advocacy Coalition assembled about 100 people at Winthrop Center to discuss the role that immigrants play in the state’s workforce.
As snow and sacks thwart Drake Maye’s passing dreams, his ‘demoralizing' legs find a way to send Patriots back to Super Bowl
LIST: Businesses, churches announce closures due to major winter storm
Businesses and some schools are already announcing closures as a significant winter storm takes aim at the Cincinnati area.
Health board denials 'severely impacted' hospital inquiry
The remarks came as oral submissions ended in the inquiry into the design and construction of Glasgow's largest hospital.
Submissions Open for 3M's Nationwide Middle School Science Competition
Finalists will receive one-to-one mentorship with a 3M scientist, national recognition, and a chance to win top prize: $25,000 and title of "America's Top Young Scientist" SAINT PAUL, MN / ACCESS Newswire / January 21, 2026 /3M (@3M) and Discovery ...
Submissions Open for 3M’s Nationwide Middle School Science Competition
Submissions Open for 3M’s Nationwide Middle School Science Competition
Submissions open for 3M's nationwide middle school science competition
/PRNewswire/ -- 3M (@3M) and Discovery Education today announced that the 2026 3M Young Scientist Challenge (#YoungScientist) is now open to entries. The...
The Democrats’ 2028 calendar fight: 12 states apply for a spot at the front of the line
Democrats are kicking off the process of setting their 2028 presidential primary calendar this month, after 12 states submitted applications to lead the process.
Readers respond: Don’t become a pawn to politics
Letters to the Editor can be submitted to letters@oregonian.com with full name and place of residence.
Two presidential elections, two seismic shifts... (Politics+) : The NPR Politics Podcast
In today's bonus episode, Don Gonyea (national political correspondent) and Deepa Shivaram (White House correspondent) each share the "most" memorable story they've worked on. Don talks about a moment in the 2016 presidential election when he started seeing a key voting group for Democrats shift to then-candidate Donald Trump. Deepa recalls the day President Joe Biden dropped out of the 2024 race and her experience covering Kamala Harris' first campaign rally as the presumptive Democratic nominee. Listen to find out how you can submit a most-type question for us to answer in a future bonus episode! To unlock this and other bonus content, and get sponsor-free listening, sign up for NPR Politics Podcast+ via Apple Podcasts or at plus.npr.org. Regular episodes haven't changed and remain available every weekday!
World Sports Photography Awards 2026 winners revealed
More than 4,120 photographers from 123 countries submitted a record-breaking 23,130 images across the 24 categories to this year’s World Sports Photography awards
Veterans' mental health resource event Saturday
A free suicide prevention and mental health support event for veterans will be held on Saturday in Duncan.
Discussing the new AI health app
Dr. Danielle Bitterman of MGH Brigham discusses the pros and cons of ChatGPT Health, an AI app designed to answer personal health questions.
Schools Ask NCAA to Withhold Data From College Sports Commission
The latest round of financial data that schools submit to the NCAA has emerged as another flashpoint in the ongoing debate over the CSC’s authority.
What Makes Men Attractive? Science Reveals the Ideal Body
Do muscles make the man? New research reveals that body fat and BMI play a bigger role in male attractiveness than most people think.
#PostPulpit Mailbag: Submit your questions for this week
Submit your questions down below.
Doseology Engages McKinney Regulatory Science Advisors to Advance Innovative Oral Pouch Product Development through Science and Regulatory Expertise
Doseology Sciences Inc. (CSE: MOOD) (PINK: DOSEF) (FSE: VU70) ("Doseology" or the "Company") a leader in biotechnology-driven consumer products, today announced a strategic partnership with McKinney Regulatory Science Advisors ("McKinney"), a premier FDA regulatory consulting firm specializing in nicotine and reduced-risk consumer products, to spearhead its regulatory submission strategy and solidify its commitment to scientific leadership in the oral pouch technology space.
Almanack Arts
Submissions are now open for the Almanack Arts Colony's 2026 Episodic Lab in Nosara, Costa Rica.
Advancing Claude in healthcare and the life sciences
Introducing Claude for Healthcare with HIPAA-ready infrastructure, plus expanded Life Sciences tools for clinical trials and regulatory submissions. New connectors to CMS, Medidata, and ClinicalTrials.gov.
Advancing Claude in healthcare and the life sciences
Introducing Claude for Healthcare with HIPAA-ready infrastructure, plus expanded Life Sciences tools for clinical trials and regulatory submissions. New connectors to CMS, Medidata, and ClinicalTrials.gov.
Red hot submission specialist returns at UFC Seattle
Valter Walker looks to continue his hot streak against Marcin Tybura
Upcoming live events across Central Coast: Hannibal Buress, Nick Offerman and more
Figuring out plans with friends and/or partners can be difficult. If you’re looking for live music and entertainment, here is a list of upcoming events across the Central Coast.
House passes bill to extend health care subsidies amid GOP opposition
The House passed a bill to extend health care subsidies with bipartisan support, but its future in the Senate remains uncertain.
Mid City Ballroom seeks rezoning to obtain alcohol license
Mid City Ballroom, the intimate concert venue on South Acadian Thruway, has submitted a rezoning application as it looks to move away from its long-running BYOB model and begin selling alcohol on … Already an INSIDER? Sign in. We are glad you enjoy reading Business Report. Continue reading this story and get ACCESS to all […]