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Telefónica is embedding climate action across its business to accelerate its path to net-zero emissions by 2040
Telefónica is embedding climate action across its business to accelerate its path to net-zero emissions by 2040
Stocks making the biggest moves premarket: Constellation Energy, Option Care Health, Lennar, P&G and more
These are the stocks posting the largest moves in early trading.
Exclusive: At Starbucks, the future is smaller
Starbucks is on a mission to recapture its roots as a place to sit down for a cup of coffee. But it doesn’t think it needs a big footprint to deliver on that promise.
Trump draws backlash after he suggests Iran could ‘take out’ Los Angeles or San Diego
Officials in California denounced comments made by President Donald Trump as “dangerous” on Monday after he appeared to suggest Iran could “take out” Los Angeles or San Diego – major cities in a state he has often criticized.
Bella Kay on life in L.A. and her viral hit 'Iloveitiloveitiloveit'
The 20-year-old singer and songwriter scored a viral hit this year. Now she's in the mix for a coveted best new artist nod at the Grammys.
Nobel Prize in physics awarded to Francis Halzen for his work detecting cosmic particles
The 2026 Nobel Prize in physics has been awarded to Francis Halzen for his “decisive contributions to the IceCube Neutrino Observatory and the discovery of high-energy neutrinos of astrophysical origin.”
Wall Street is booming. Surging yields could shake things up
The boon comes at a time when consumer sentiment is at historic lows and with heightened concerns about the cost of living, from rising energy prices to stubborn food inflation.
‘Let Troy be Troy’: How Maine Democrats’ hope to beat Sen. Susan Collins is working to quiet doubters
As Democrats enter the homestretch of their longtime quest to defeat Maine GOP Sen. Susan Collins, they are placing their hope in a fifth-generation logger from the state’s rural north who speaks with a distinct Allagash accent, displays an apparent penchant for boba tea and has never been this close to the national spotlight before.
The Senate is up for grabs. Plot each party’s best path to winning
As many as 10 key Senate races identified by CNN that are on the ballot in November will likely determine which political party controls the chamber.
Democrats are taking big chunks of GOP voters in key Senate races, polls show
President Donald Trump has never had worse poll numbers with his base than he does ahead of the 2026 midterm elections.
I review AirPods, MacBooks and more. Here are the 9 best Amazon Prime Day Apple deals
Our tech reviewer has tested tons of Apple gear and is separating the wheat from the chaff when it comes to Amazon’s October Prime Day deals.
Trump may be in political trouble. But Trump-style global populism isn’t
President Donald Trump might be in a political hole, but his brand of conservative populist nationalism is flourishing across the globe.
How consumer healthcare brands are adapting FMCG media strategies
Can Opella adapt FMCG marketing without also importing the issues facing that category?
CNN, MS NOW and Politico make final written effort to convince judge to maintain White House access
Lawyers for CNN, MS NOW and Politico said Monday that the White House had offered no new evidence to support their repeated claims that the news outlets’ reporting endangered national security.
Trump takes midterms message to deep red Nebraska
President Donald Trump gave supporters a campaign-style speech in Nebraska in a continued effort to fire up the GOP base ahead of the midterms. CNN’s Jeff Zeleny reports.
Trump says he will pay for campaign-style ads himself after backlash over taxpayer-funded effort
President Donald Trump said Monday he will no longer use taxpayer money to fund a series of promotional television ads, announcing that he will instead pay for them with funds raised for MAGA, Inc., the pro-Trump super PAC.
Retiring GOP Senator reveals his ‘WTF’ moments during the second Trump term
Trump uses anti-transgender slur to attack South Carolina Senate candidate
President Donald Trump on Monday used an anti-transgender slur to attack Democratic South Carolina Senate candidate Dr. Annie Andrews, as he tries to push his hand-picked GOP candidate, Sen. Darline Graham, over the finish line in the midterm election.
New York declares first US measles disaster emergency since 2025 surge
New York Governor Kathy Hochul declared a statewide disaster emergency on Monday over a measles outbreak, the first such declaration by a U.S. state since cases began surging in 2025.
CMS student among top 30 finalists nationwide in science competition
Isabella Garry is being honored for a project exploring whether natural materials can remove microplastics from simulated stomach fluid.
Send us your questions for Texas Senate candidate James Talarico
Calling all Texas Republicans, Democrats, and Independents! Are you a registered voter in Texas? Then submit questions for CNN & Jubilee’s Town Hall with James Talarico on Wednesday, October 14 and engage in a direct conversation with the Texas Democratic Senate candidate on the issues that matter most to you.
CBS Sports Chief David Berson To Expand Portfolio As TNT Sports Chief Luis Silberwasser Exits
David Berson, who has led CBS Sports as president since 2024, will expand his portfolio after the close of the Paramount-Warner Bros. Discovery merger. The exec will take responsibility for sports across Skydance, the soon-to-be-umbrella over CBS and TNT Sports and their respective parents, Paramount and WBD. The $111 billion merger is due to close …
Why I Don’t Think Ride Or Die Should Have Been Cancelled (And What Company Should Save It...)
(Welcome to my weekly streaming ratings report, the single best guide to what’s popular in streaming TV and what isn’t. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. If you were forwarded this email, please subscribe to get these insights each week.) So…I recently came across a Reddit thread, talking about films on streaming, wondering why there are no reliable sources out there for streaming ratings data. Sigh. Honestly, as annoyed as I am that so many still don’t realize that we have streaming ratings, I somewhat get it. Until now, there was such a long delay between when a show or film came to streaming and when we got its viewership data; I understand why people were confused. (But, as you know, this just changed.) Also, even back in the day, how many people knew how well films did on television? Luckily, as a reader, you’re in the know. Okay, on to this week’s issue. I want to take a look at Prime Video cancelling Ride or Die and whether I agree with that decision. Overall, we didn’t have any breakout hits (no TV shows landed over 20 million hours according to Nielsen) but we have a lot of steady performers on the streaming charts. Plus, we’ll look at where $50 million in missing box office dollars went. (Spoiler: straight-to-streaming.) All that, plus new episodes of The Secret Lives of Mormon Wives, Supergirl heads to streaming, a new YA show does well on Netflix, the viewership for the Daily Wire’s $50 million fantasy show, what TV show hit-maker can’t make streaming hits, CD sales, all the flops, bombs and misses, and a whole lot more. Let’s dive right in! (Reminder: The streaming ratings report focuses on the U.S. market and compiles data from Nielsen’s weekly top ten viewership ranks, Luminate’s Top Ten Data, JustWatch and Reelgood interest data, Samba TV household viewership, company datecdotes, Netflix hours viewed data, Google Trends, and IMDb to determine the most popular content. While most data points are current, Nielsen’s data covers the weeks of September 7th to September 13th, 2026. You can find a link to my terminology here.) Subscribe Television - Ride or Die Is a Hit…But It Got Cancelled? What The Data “Says” I hate the phrase “here’s what the data says”, even though sometimes I find myself using it. If data just told us everything, we data folks would be out of a job! Data is often messy, complicated and nuanced. When it comes to strategy, many of the best decisions can’t actually use “data”, since it’s vastly too complicated to model. Anyways, I’ve been singing the praises of Prime Video’s Ride Or Die this summer, a show that did very well for them. And yet…it got cancelled. Now, usually when a show gets cancelled, a bunch of websites say “a hit show got cancelled”... Here’s the thing, though: in this case, they’re right! The data “says” that this show was a hit. Specifically, out of 522 first seasons to make a week on the Nielsen charts since 2020, it’s the 75th biggest. On Amazon, Ride or Die is eighth out of 41 first seasons: That’s top 15th percentile all time, almost exactly, which is my definition of a “hit”! I mean, outside of Reacher, Amazon needed a hit this summer! (Admittedly, Off Campus did well for Amazon in the spring, but Ride or Die performed even better.) So what happened? Why did Amazon cancel one of their rare 2026 bright spots? Well, Deadline reported a reason—which I’ll get to—but I’d break it down into three relevant questions: What is a given streamer’s reasoning? Is that reasoning sound? Could the stated reason not be the real reason? According to Deadline, Amazon felt the show “over-indexed” in middle-aged women. (This was based on leaks from within Amazon.) The logic is this: Amazon already reaches this demographic because of unlimited two-day shipping bundled with Prime, so they don’t really need more shows like this. Now, it’s my job to ask if that’s a good reason, and I’ll be honest, in this case, I don’t think it is. Sure, this show may “over-index” in middle-aged women—I’ll just assume that’s the case here—but I think folks often oversell how important over-indexing actually is. When a show is a “hit”, it isn’t a bit bigger than its rivals; it’s usually multiples bigger. For example, Elle only made the charts for two weeks at 8.3 million hours each. So Ride or Die was 80% bigger in its first two weeks, and likely had a much stronger hold, with its terrific 13 million hours in week three. Ride or Die was nearly three times bigger than Sterling Point through three weeks too. And that means that _Elle, Sterling Point a_nd other Amazon YA shows need to not just over-index a little with younger women (assuming that’s who Amazon prefers over middle-aged women), but massively over-index. Otherwise, more people in that demo (and a bunch more besides) likely watched Ride or Die. (I’ll try to explore this concept more in a future article.) And don’t get me started on how Ride or Die did compared to a certain (very, very popular, possibly the world’s most popular) YouTuber’s reality show…which didn’t make the charts after its first week and likely cost much, much more than Ride or Die. All to say, Amazon-MGM Studios/Prime Video can tell reporters that this show didn’t reach the right audience, but that excuse feels weak to me. So this leads to the third question: could other reasons have come into play? Yes! Renewal or cancellation decisions rarely (I’m tempted to say “never”) boil down to one variable. At its simplest, it’s two things: budget versus viewership. But often factors like critical acclaim, ownership and, yes, personal opinion come into play. In this case, Amazon has a new executive running things, and this show isn’t owned by Amazon-MGM Studios (unlike Elle). And yes, it may not have indexed with the right target viewers, too. Likely all of those factors came into play.1 My guess is ownership ended up mattering most. Amazon doesn’t own Ride or Die. It’s actually produced by another major studio. Fortunately/allegedly, this show is being shopped around. I can think of one brand new CEO who should consider it for one of his two major streamers…especially if he wants to rebuild goodwill in Hollywood. His name is on this list of exec producers of Ride or Die… If David Ellison needs some goodwill—and he does—rescue this female-led show tomorrow and grab some good headlines for a day. The data justifies it. Quick Notes on TV We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… How The Secret Lives of Mormon Wives latest season did on Hulu, post-controversy... Whether Supergirl soared on HBO Max... Why the box office is losing money due to the streamers... The viewership for the Daily Wire’s $50 million fantasy show... Updates on The Gentlemen, Lanterns, Outer Banks, King of the Hill and more... What former hit-maker has three streaming flops in a row... Whether The Mandalorian and Grogu popped in week two... All the flops, bombs and misses... And a whole lot more... ...please subscribe! We can only keep doing this great work with your support. If you want an idea of just how much content you’d get in a full issue, check out this older issue. Coming Soon! Oh man, we’re almost caught up! We just have two more issues, then the streaming Ratings Report will be coming out just two weeks after a TV show premieres! Next issue, I’ll be looking at the first two weeks of the NFL Thursday night games on streaming, a huge new spinoff, Reacher’s Neagly on Prime Video, and the latest edition of Monster: The Lizzie Borden Story on Netflix, the return of Slow Horses on Apple and MobLand (quietly one of their biggest shows) on Paramount+, and Dancing with the Stars on both ABC and Disney+. Plus I’ll take a look at animation for adults in 2026. The week after, a ton of movies are coming to streaming: Toy Story 5 on Disney+, Backrooms on HBO Max, Jackass: Best and Last on Paramount+ and The Breadwinner on Netflix, plus a Unabomber film on Netflix and a romcom on Prime Video. Woody Harrelson and Matthew McConaughey have a show on Apple, along with a game show inspired by Willy Wonka that everyone seems to hate. Long term, some crazy (but hopefully crazy like a fox) IP news. FX ordered a new Sons of Anarchy show from Charlie Hunnam, but it’s not about the biker gang. No, it features the show’s cast playing themselves in a new “meta-thriller”. Huh. And a lot of the cast is coming back. Next, Ryan Gosling is producing a Flintstones movie about a “grown-up Bamm-Bamm Rubble”. Also, huh. This one is in “early development” so we’ll see what happens. Both projects are based on IP, but also seem to have crazy takes on the IP, which I like.
Trump won this district by 10 points. This Democrat thinks he can win it by winning back Latinos
Trump is clearly trying to buy votes with taxpayer money
President Donald Trump is ramping up his efforts to use taxpayer money and resources to help Republicans win the 2026 midterm elections.
Astronomers discover possible planet born from a dead star’s ashes
A second-generation planet might be orbiting a white dwarf, in an astronomy first, according to new research.
‘A five-alarm fire’ confronts President Trump in red-state October blitz
The midterm elections were just two days away the last time a sitting president visited Grand Island, the fourth-largest city in the middle of one of the nation’s most reliably Republican states.
Karoline Leavitt joining Fox News as on-air contributor
Former White House press secretary Karoline Leavitt will become an on-air Fox News contributor next month, weeks after stepping down from her prior role to spend more time focusing on her family.
Senua At Risk Of Cancellation As Ninja Theory Employees Announce They've Left The Studio
"It’s incredibly sad knowing that we won’t get to finish..."
Reba McEntire, Ella Langley, Kelsea Ballerini will perform at Dolly tribute
ABC's Dolly Parton tribute unites music's biggest names, from Carrie Underwood to Vince Gill. Here's how to get tickets.
Supreme Court declines First Amendment case of students forced to remove ‘Let’s Go Brandon’ sweatshirts
The Supreme Court on Monday declined to take up a First Amendment appeal from two middle school students who were ordered to remove sweatshirts emblazoned with the words “Let’s Go Brandon,” steering clear of a case that could have clarified the power schools have to police potentially offense speech in the classroom.
‘Interstellar,’ ‘Nope’ headline Great Lakes Science Center’s DOME Movies After Dark fall lineup
The series also includes "V for Vendetta." Films are presented in the science center's DOME theater, with a six-story-high screen and an 11,600-watt digital sound system.
AirTags are on sale ahead of Amazon Prime Day. These early deals are worth shopping
Amazon Prime Day is tomorrow, but these early AirTag deals are already worth snagging.
Democrats release midterms ad featuring family of Epstein victim Virginia Giuffre
The campaign arm working to elect House Democrats released a political advertisement on Monday featuring the family of Virginia Giuffre, who was the first victim of Jeffrey Epstein to go public with allegations of abuse.
Yale School of Medicine On the Science of Childhood Anxiety, Say, Anxiety Disorders Are the Most Common Mental Health Challenges In Youth
Credit: Matt Bradbury October 5, 2026 - By Isabella Backman - Anxiety disorders are the most common mental health challenges in youth. Left untreated, they can disrupt the lives of both children and their families. The good news is that with intervention, most children will overcome these conditions. Across Yale School of Medicine, scientists are working to understand anxiety at every level, from common anxious behaviors to molecular biomarkers in the brain. They are using their findings to develop and disseminate new evidence-based treatments for childhood anxiety. Today, the go-to treatment for childhood anxiety disorders is cognitive behavioral therapy (CBT). This is a form of psychotherapy that teaches children skills for confronting anxious thoughts and helps them practice managing situations that cause anxiety. While it is the gold-standard treatment backed by considerable scientific evidence, up to 50% of children will not see sufficient benefit from CBT alone. Wendy Silverman, PhD, Alfred A. Messer Professor in the Child Study Center, co-directs the Anxiety and Mood Disorders Program alongside Eli Lebowitz, PhD, associate professor in the Child Study Center. One of their main interests is learning how to improve outcomes beyond CBT. “We’re developing cutting-edge, research-based knowledge that can reduce the suffering that anxiety causes children and their families,” says Silverman. Changing parent behavior YSM experts are investigating how to improve CBT outcomes for children by involving the parents. Silverman’s research has uncovered two main components of parent intervention that improve childhood anxiety: not enabling children to completely avoid the things that make them anxious and taking steps to enhance their autonomy. Parents may unintentionally reinforce their child’s anxiety by allowing them to avoid what makes them anxious. They also may unintentionally limit the children’s sense of autonomy by being overly intrusive. “One of the things that we take pride in is that we’ve focused on trying to understand what parents need to do, and to test our ideas and see if changing the parents’ behaviors is enhancing the effects of CBT,” Silverman says. “Our findings thus far suggest that they do." As much as CBT can be helpful, it can also be challenging to get one’s child to do the necessary steps for CBT to work. This is one important reason why Lebowitz created a novel intervention program for parents named Supportive Parenting for Anxious Childhood Emotions (SPACE). Existing intervention programs often teach parents to act as therapists for their child, such as training them on how to practice breathing exercises. “It makes sense, but this doesn’t work very well in practice,” says Lebowitz. “And part of the reason, I think, is that it’s not easy to get your kid to do things, especially if they’re not excited about doing it.” SPACE is unique because it focuses entirely on parent involvement and changing parental behavior—children are not involved in the sessions. For example, parents learn how to use supportive messages that convey confidence that their child can tolerate and manage distress. “It might sound like a parent saying to a child, ‘I get that this is really hard for you, but I know that you can handle it,’” Lebowitz says. The program also works with parents to identify the ways in which they are accommodating anxious behaviors. “We’ll pick one thing that parents are doing that is an accommodation and help them make a detailed plan for how they’re going to change that,” Lebowitz explains. Treating Anxiety in Children and Adolescents Much of the existing research on SPACE has focused on parents of children under age 14. Ongoing studies are now exploring its use with parents of older teens. “Both anxiety and accommodation can interfere with normative developmental shifts during the teen years, including increased autonomy and individuation from parents,” says Rebecca Etkin, PhD, associate research scientist in the Child Study Center. “In this sense, SPACE may be particularly well-suited for anxious teens and their parents. We want to see whether it is effective during this distinct developmental window.” Unfortunately, many families in need of CBT face barriers, including limited availability of services and geographic constraints. One way to improve access is digital interventions. Silverman and her team are developing an evidence-based digitized intervention program for parents that they can access directly from their computer or smart phone. “The work we’re doing will be one of the very few parent interventions that is digitized and importantly tested for effectiveness,” she says. Creating interventions for anxiety-related challenges Silverman and Lebowitz recently received a generous gift to develop and test other interventions that help parents reduce other child anxiety-related behavioral and emotional difficulties, such as restrictive eating and unexplained somatic symptoms. One of these projects in particular focuses on understanding the risks of social media and its potential benefits, including offering a sense of connection. “A lot of research has focused on the idea that social media is harmful and the less of it the better,” says Lebowitz. “But we actually see is that this is not quite right—there are negatives, but there are also positives. So, we’re trying to get a little bit more nuanced of a picture.” The team is working with teens with social anxiety and their parents over an extended period to better understand their social media habits and how their anxiety levels affect engagement with different platforms. The teens will answer questions sent to an app on their phones about mood and social media usage in an effort to capture emotional responses as they unfold. “We hope to develop interventions that can help make the best of social media while protecting against the more problematic effects,” Lebowitz says. The brain’s role in anxiety Researchers are also testing therapies to address anxiety at the neurological and molecular levels. In collaboration with Dylan Gee, PhD, professor of psychology in Yale's Faculty of Arts and Sciences, and Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience at Yale School of Medicine, Lebowitz and Silverman are using brain imaging to identify changes in a child’s brain before and after parents enroll in SPACE. In one study, children viewed anxiety-inducing images while undergoing magnetic resonance imaging (MRI); the researchers conducted scans with and without the children’s parents nearby. Before SPACE, children’s brains were better able to activate the regulatory circuitry needed to turn off an anxious response when their parents were nearby. But after SPACE, children could activate this circuitry even without the parent around. “As parents work on gradually reducing some of their accommodations, you can see a child get better at regulating their own fear system in the brain,” Lebowitz says. “It’s remarkable.” Research into the molecular underpinnings of anxiety can also inform new childhood anxiety treatments. In a recent study, Lebowitz, Silverman, and Flora Vaccarino, MD, Harris Professor in the Child Study Center, discovered that a protein known as fibroblast growth factor 2 (FGF2) could be protective from the toxic effects of stress. FGF2 levels in children and their parents were linked to the children’s risk of developing anxiety and depression, the study showed. The findings could help explain why some children who are exposed to early life trauma such as poverty or abuse are more prone to developing mental health disorders. And FGF2 could be a target for treatment. “This is very novel because it starts to give a clue to what is the molecular chain that connects those lived experiences to the actual psychological outcomes,” Lebowitz says. New ways to study and treat childhood anxiety Michael Crowley, PhD, associate professor in the Child Study Center, collaborates with Silverman and Lebowitz to study the role that attention plays in development and maintenance of childhood anxiety. There is a large body of research that shows that anxious children, like anxious adults, are prone to focus on threatening stimuli such as angry faces compared with neutral faces. This has led to innovative interventions that involve attention retraining. The idea is that if experts train children to look away from threatening stimuli, it may reduce their anxiety—especially children with social anxiety who are most prone to attend to threats. The researchers have just completed a clinical trial for attention retraining with 10- to 14-year-olds with social anxiety disorders and are currently analyzing the findings. Besides this innovative attention retraining research, as Crowly notes, “I like to design tasks that are engaging to kids,” Crowley says. “My goal is to assess something without the kids knowing what we are assessing.” With this goal in mind, Crowley has created a virtual game, named Boom, to study threat processing in children with anxiety disorders. The game is similar to that of hot potato—the child and three digital players take turns virtually passing a ball to each other’s gloves. At some point, the ball turns into a bomb, and as the bomb lands in each player’s glove, the outline of the glove turns yellow. The goal is to avoid having the bomb go off in your glove. What isn’t obvious is that the game is designed to measure different types of threatening stimuli, both ambiguous and direct. In the game, the direct threat occurs as the bomb is traveling towards your glove. The ambiguous threat is the yellow outlined glove as it is unknown where the bomb will travel next. While children play the game, Crowley’s team measures their brain activity using electroencephalography (EEG). The researchers have discovered that in kids with anxiety, the brain reacts more strongly to ambiguous threats than it does in their peers, but less strongly to direct threats. They believe that the initial abnormally large brain response to not knowing where the bomb is going impairs the brain's ability to properly respond when the threat is actually traveling the child’s way. “The brains of children with anxiety are unable to differentiate between threats you need to do something about and those that are not your problem.” Michael Crowley, PhD, develops innovative games for studying anxiety in children and adolescents.Credit: Matt Bradbury Based on these insights, Crowley hopes to study whether interventions like attention training could restore appropriate threat processing. Crowley’s team is also working on a test called the Balloon Risk Avoidance Task, which evaluates risk-taking and avoidance behaviors. It features a digital balloon that is full of air and about to burst. Kids have six seconds to let air out of the balloon. The more air they let out, the less risk they face that the balloon will pop. But at the same time, the balloon becomes less valuable as it deflates. “The more air you keep in the balloon, the more points you get,” Crowley explains. So far, the researchers have found that when the balloons pop unexpectedly, teens with social anxiety show distinct brain responses. Studying these responses can help psychologists understand the underlying pathways driving the various manifestations of anxiety. The genetics of anxiety When Thomas Fernandez, MD, associate professor in the Child Study Center and of psychiatry, was still in training, there was a lot of excitement about understanding the genetics associated with autism spectrum disorder. Since then, scientists have identified around 250 genes associated with autism. The genetic contribution to anxiety disorders, on the other hand, has historically received less attention. Anxiety is less heritable than autism, but the genetic contribution for anxiety disorders that emerge in childhood may be higher than for anxiety disorders overall. While scientists estimate the heritability of anxiety disorders in general to be around 30% to 50%, some studies suggest higher heritability for certain childhood-onset anxiety presentations. “I saw firsthand how researchers in the field went about finding vulnerability genes for autism,” Fernandez says. “So, we’re using a very similar playbook for childhood anxiety.” “I saw firsthand how researchers in the field went about finding vulnerability genes for autism. So, we’re using a very similar playbook for childhood anxiety.” Thomas Fernandez, MD Associate Professor In the Child Study Center and in Psychiatry Now, Fernandez and Emily Olfson, MD, PhD, assistant professor in the Child Study Center, are studying children and their parents to identify genetic changes that are present in the child but not the parents, known as “de novo mutations.” “All of us have some de novo mutations—maybe about 50 to 100 sprinkled throughout the genome,” Olfson says. “But when they occur within the coding regions of genes, they can be really disruptive.” Previous research shows that people with autism have higher rates of damaging de novo mutations than the general population. In 2022, Olfson, Lebowitz, Silverman, and Fernandez published a study on 68 children and their families that found that children with anxiety had similarly high levels of these mutations. Studying de novo mutations can help point the researchers to where they should be looking for genes associated with anxiety. “The end game is using the genes to steer us toward the right part of biology that we can then target to come up with better treatments,” Fernandez says. Building on those findings, the team is now studying more families to better understand how these de novo mutations, along with other genetic and environmental factors, shape pediatric anxiety disorders. They recently received a National Institutes of Health grant to enroll 750 new families over the next five years. Olfson is the principal investigator, with co-investigators Lebowitz, Fernandez, Silverman, and Shuangge Steven Ma, PhD, department chair and professor of biostatistics at Yale School of Public Health. Neurodevelopment, Risk Genes, and Mental Health Conditions - The Olfson Lab Joel Gelernter, MD, Foundations Fund Professor of Psychiatry, is interested in how different anxiety disorders differ genomically. “We are studying social phobia, panic disorder, and generalized anxiety disorder, working to understand why people differ in their risk to these specific anxiety disorders and evaluating various risk factors,” he says. Gelernter was recently involved in one of the largest studies to date of the genomics underlying anxiety disorder. The study included around 122,000 people with anxiety disorders and around 730,000 without. It found that some genetic differences associated with anxiety were linked to signaling that helps reduce overactivity in the nervous system. Many anxiety medications available today work by targeting this process. “It’s nice when the biology that you get out of a large genome-wide study ratifies things that we already know because that can help increase confidence in further findings from the study,” Gelernter says. Uncovering the neurobiology of psychiatric disorders John Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and chair of the Department of Psychiatry, is interested in the neurobiology of psychiatric disorders, including post-traumatic stress disorder (PTSD), of which anxiety is a major symptom. In the late 1980s, Krystal’s team discovered that the drug yohimbine activated symptoms in patients with PTSD. “This was the first time we could link a specific biological mechanism to the symptoms of PTSD,” Krystal says. At the time, he adds, this finding was highly controversial. “A lot of people felt that PTSD was a purely psychological syndrome that didn’t have an underlying biology.” Since then, Krystal has dived deep into understanding the neurobiology of PTSD to learn how to better treat it. His team is evaluating the use of ketamine and psychedelics. These would be among the first treatments to be developed specifically for PTSD. They may also be applicable for other disorders including anxiety disorders, Krystal adds. An important gap in PTSD treatment is the absence of biological tests that inform how to best help patients manage their PTSD symptoms. A doctor doesn’t diagnose cancer based on how they feel. Rather, they use tests of the biology of the cancer to determine the best course of treatment. “And we can’t do that in any psychiatric disorder other than Alzheimer’s disease,” Krystal says. “But now we are building a foundation for this approach to the treatment of anxiety disorders for the first time.” Source: Yale School of Medicine
Nobel Prize in medicine awarded to three scientists for their work ‘concerning light-gated ion channels and optogenetics’
The 2026 Nobel Prize for physiology or medicine has been awarded to three scientists – Karl Deisseroth, Peter Hegemann and Georg Nagel – for “their discoveries concerning light-gated ion channels and optogenetics.”
Anthropic expected to IPO despite market uncertainty, AI slowdown calls
Wall Street is gearing up for Anthropic’s expected mega initial public offering, a major test of investors’ appetite for one of the AI industry’s leading firms. Just weeks ago, its CEO called for an industry-wide slowdown over growing safety concerns.
The 10 Senate seats most likely to flip in 2026
Nearly four weeks out from Election Day, the Senate battleground map is growing after signs of improvement for Democrats in several red-leaning states.
‘I’m here to save lives’: Inside the unlikely Biden-Trump partnership to secure a Gaza ceasefire
Secure rooms in the US Capitol are cavernous compared to the White House Situation Room. They are designed for full committees or larger gatherings, not intimate discussions. On Nov. 20, 2024, Jake Sullivan and I had gone to one of those rooms to brief our successors two weeks after Donald Trump resoundingly defeated Kamala Harris.
An 8-justice Supreme Court to decide whether cities can sue oil companies for climate change impacts
The Supreme Court will hear arguments Monday in one of the most important climate change cases to reach its docket in years, a multibillion-dollar effort to hold major oil companies like ExxonMobil liable for the damages caused by planet-warming pollution.
Trump fights on home turf as Democratic midterm hopes rise
Republicans are defending territory they never expected to be at risk four weeks before Election Day, as President Donald Trump implores voters not to desert his party with the promise of more cash giveaways.
Zakaria: California’s private sector ‘massively overperforms’ while ‘government underperforms’
Fareed Zakaria on his takeaways from top tech meeting and what’s difficult about regulating AI
US removes all Air Force bombers from Fairford base amid terrorism concerns
The United States has moved long-range bombers back to their American home stations days after the British government arrested a number of individuals in connection with an alleged Iranian plot to target the UK airbase where the planes had been stationed.
‘When I saw the video I cringed’: Why CNN anchor says to stop analyzing kids’ sports on the ride home
I’ve built hundreds of Lego sets. These early October Prime Day deals are actually worth buying
As an avid Lego builder, I found the best early October Prime Day deals on Lego Star Wars sets, brick-built plants and even F1 cars that you’ll find at Amazon.
Latino voters, souring on Trump, swing toward Democrats, new poll finds
The growing electorate played a critical role in Trump’s 2024 victory. Now, sentiment is dipping, particularly on economic issues, a new NBC/Telemundo poll finds.
Supreme Court heads into new term with one eye on President Trump
When the Supreme Court kicks off a new term on Monday, it’ll be without a docket full of Trump-driven, separation-of-powers blockbusters that defined the last term — for now.
Hassett blames ‘partisan pollsters’ for pessimistic consumer sentiment and says ‘the economy is booming’
Christa Pike’s attorney calls on Tennessee Gov. to commute her sentence: She’s been through ‘some really really bad’ torture
Christa Pike’s attorney calls on governor to commute her sentence: She’s been through ‘some really really bad’ torture
Could Democrats lose a Senate race in New Hampshire? A GOP candidate with a famous name tries to flip the seat
PlatinumGames boss hints he wants to expand Bayonetta as Stellar Blade director calls the series "indispensable"
PlatinumGames president Atsushi Inaba says he "strongly wants" to expand Bayonetta, three years after series creator Hideki Kamiya left the studio.
Trump announces leadership of AI task force
President Donald Trump on Sunday announced the creation of a “Super Intelligence Force” to “ensure that America continues to lead the world” when it comes to artificial intelligence.
Inside Democrats’ efforts to secure Election Day and respond to fears of Trump interference
Ahead of the November midterm elections, top Democrats are planning for doomsday scenarios for how President Donald Trump and his administration could intervene in the voting process and laying the groundwork for a forceful response.
Where’s Blade? Fans wonder why Marvel Studios cutbacks seem to be landing on Black heroes
Mahershala Ali has said he’s moved on from the “Blade” reboot, making it another MCU project that’s fallen by the wayside. Black fans are asking whether Black characters are being purposely neglected and sidelined.
Why doesn’t high speed rail work in America?
American railroads were once the envy of the world and the engine of its industrial age. But that hasn’t been the case for more than half a century.
The counties to watch on the massive midterm elections battlefield
The breadth of the public backlash against President Donald Trump’s tumultuous second term is rapidly widening the campaign battlefield for 2026.
Future of French far-right star in balance after antisemitism claims
After one of the most meteoric rises in the history of French politics, Jordan Bardella, the 31-year-old top ally of Marine Le Pen, is fighting for his political life after
Huijsen and Cucurella rested for Spain in Czechia win
Both played the full 90 minutes against Croatia
Ontario Reign drop home opener to Coachella Valley Firebirds
The Ontario Reign fall 6-2 to the Coachella Valley Firebirds in Ontario's home opener Saturday night. Jani Nyman scored three goals and Jagger Firkus found the back of the net twice while Koehn Ziemmer and Jared Wright scored for the Reign. Ontario starts the 2026-27 AHL season at 1-1 with two points.
Trump rally attendees react to war and the economy ahead of the midterms
CNN’s Alayna Treene speaks with Trump supporters about their views on issues like the Iran war, gas prices and the economy, as the US president campaigns in Vandalia, Ohio in a bid to help Republicans retain control of Congress in next month’s midterm elections.
Ken Paxton’s estranged wife backs him without saying his name
Texas state Senator Angela Paxton, Ken Paxton’s estranged wife, threw her support behind the Texas GOP Senate nominee without naming him, saying in a new ad that she will be “voting for the Republican ticket.” The ad comes after Paxton urged Republican women in remarks last month to support GOP candidates even if they have reservations about them.
Trump’s spat with GOP lawmaker over Daylight Saving Time
President Donald Trump railed against Sen. Tom Cotton in a series of posts on Saturday, accusing the Arkansas Republican of holding up a bill that would make Daylight Saving Time permanent and encouraging people to call the senator at his cellphone number.
Trump advocates for mail and early voting despite historically opposing both
President Donald Trump said Americans should cast their ballot using “every appropriate tool,” in a pre-recorded video imploring Republicans to vote in the midterm elections, including using methods that he has historically opposed like early and mail voting.
F.D.A. Classifies Salad Dressing Recall to Highest Health Risk
Salata Dressings initiated the recall of its Jalapeño Avocado Dressing in August over concerns about possible salmonella contamination.
PlatinumGames talks Nintendo Switch 2, offers brief comment on Bayonetta's future
PlatinumGames has offered a few words about Nintendo Switch 2 as well as the future of Bayonetta. PlatinumGames CEO Atsushi Inaba was recently taking part in a joint discussion with Shift Up’s Kim Hyung Tae. For those who missed the news, the companies recently announced a collaboration which will bring special Bayonetta costumes to Stellar Blade in time for the...
Trump posts GOP lawmaker’s phone number amid spat over Daylight Saving Time
President Donald Trump railed against Sen. Tom Cotton in a series of posts on Saturday, accusing the Arkansas Republican of holding up a bill that would make Daylight Saving Time permanent and encouraging people to call the senator at his cellphone number.
Nebraska vs Maryland – Game Thread of Winning Fun!
Time: 3:00pm CST Location: Memorial Stadium, Lincoln, NE Surface: Hellas Turf (Blessed by the Bobfather himself in Husker Valhalla) Wagering Info: Huskers -14 1⁄2 . O/U – 52 1⁄2. Moneyline: Nebraska +116, Maryland +666 ($100 wager) (FanDuel) Series Record: Nebraska is 3-1 vs. Maryland all-time with all 4 games being played after the Huskers joined the Big 10. The last two games […]
Ken Paxton’s estranged wife backs his candidacy — without mentioning him by name
Ken Paxton’s estranged wife threw her support behind the Texas GOP Senate nominee without naming him, saying in a new ad that she will be “voting for the Republican ticket.”
Trump to give $90 to senior citizens for Medicare premiums
President Donald Trump said late Friday he will give around 20 million senior citizens $90 each to help pay for their Medicare Part B premiums, marking his latest effort to dole out funds to certain Americans weeks before the midterm elections.
I’ve tested TVs and tracked Prime Day deals for 11 years. Here are the 10 best early sales
Our tech reviewer and TV tester has picked his favorite TV, soundbar and streaming device sales that arrived early for this year’s October Prime Day.
She left Vegas to live on a ‘Blue Zone’ island where people live past 100 years old
In our roundup of travel stories this week: a hiking trail through the “Mountains of Heaven,” why Champagne is getting boozier, plus a woman who found joy by moving from Las Vegas to an Italian island.
A growing number of House Republicans privately believe they won’t win the House
Four weeks to Election Day, a growing number of House Republicans privately fear their chances of holding onto the majority are vanishing and have begun focusing on how to limit the size of a potential Democratic wave.
Democrats dream of putting Florida back in play. Are they squandering their chance?
Democrats have struggled to compete in the state for years, but a surprisingly tight race for governor has their hopes up — despite a huge financial deficit.
America wants to wean itself off Chinese technology. Will the pain pay off?
Seven years after founding a robotics startup in San Francisco, Rajat Bhageria is confronting a daunting new task: building robots without any help from China.
Breaking down Trump’s new ‘drug factories’ claim about Iranian nuclear sites
The president’s refusal to admit the likely gaffe follows a pattern of insisting he is always correct.
Culture refocuses attention on the Palestinian cause: ‘It has always been central to political struggle’
Musicians’ tours, film festivals and literary forums keep the flame for Gaza alive and spark debates about the limits of free expression and the concepts of censorship and cancellation
What we know about Trump’s latest taxpayer-funded ad campaign
The Trump administration has created at least 13 campaign-style ads as part of its controversial taxpayer-funded, multi-million-dollar effort to promote President Donald Trump and his policies. CNN’s Betsy Klein reports.