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Apple accuses OpenAI of telling recruits to bring Apple prototypes to interviews
Apple accuses OpenAI of telling recruits to bring confidential prototypes and hardware to job interviews in a new trade secrets lawsuit
MAGA's attack on science is even worse than it looks
In my post on America’s 250-year anniversary, I argued that respect for the individual was the “secret sauce” in the U.S.’ long-lasting preeminence among nations. But it was certainly not the only factor. There were plenty of institutional innovations that helped the U.S. stay on top — economically, militarily, and in terms of the attractiveness of its society. One of these was American science. Today we take things like the modern research university, government grants for science, public-to-private research spinoffs, etc. for granted, but a lot of that infrastructure wasn’t there before World War 2. It was either invented or scaled up massively by the U.S. government in the postwar period, led by far-sighted scientist-bureaucrats like Vannevar Bush (pictured above). If you want to read about this history, a good place to start would be Jonathan Gruber and Simon Johnson’s excellent book Jump-Starting America. Those scientific institutions didn’t exist in a vacuum, however. They were backed by the U.S. government’s abiding faith in the power of science — and, even more fundamentally, by deep popular trust in the scientific enterprise. Science gave us radar and the atom bomb in wartime, and in peacetime it gave us plastics, vaccines, cheap food, and a thousand other things that made our lives easier. Science was also the driver behind American industry — chemicals, aerospace, telecommunications, computers, electronics, and so on. We owed science our jobs, our livelihoods, our comfortable living standards, and our greatness and power as a nation. It’s little wonder that both political parties, even as they fought viciously over other issues, were steadfast in their support of science. For a long time, the only people who distrusted science were a hippie fringe on the left who disliked modernity (or thought they did, anyway), who also disliked American industry and American power, and who subscribed to an early version of degrowth environmentalism. America’s scientific enterprise is still strong, especially compared to the systems in Europe, Japan, Korea, and other developed countries. It has lost a lot of ground to China in a relative sense, but a lot of that is because of China’s incredible growth; as China has poured untold amounts of money and talent into its research labs, spending and output have overtaken the U.S. by some measures. There are a few ways in which China’s rise creates problems for American science — for example, top scientists can choose to work in China instead of in the U.S. — and of course there’s the concern that China’s technological strength will help its military to reign supreme. But overall, China’s rise in science should be good for American science, since American scientists can use Chinese discoveries for free and build on them. The much bigger problem is that the scientific enterprise America built during and after World War 2 is now being threatened with absolute decline. The biggest problem, of course, is that much of the country — the Republican half — has basically lost faith in the scientific enterprise. To what degree this loss of faith is justified is an open question, and deserves to be discussed openly. But the larger point — that the system that powered American dominance is under threat — is true either way. Most Americans still trust science, but MAGA Republicans don’t There’s a myth, popular in right-wing circles, that scientists have lost the trust of regular Americans — either due to the increasingly left-wing composition of academic departments, or to misbehavior during Covid, or to DEI-related research taking over science, etc. This also fits with a wider narrative that Americans are losing trust in all of our institutions. But it just isn’t true. Poll after poll shows that on the whole, Americans still trust scientists and want to spend more on science. For example, here’s a Pew poll from late 2025 showing that although about a fifth of Republicans did lose confidence in science in 2020, two thirds still have at least “a fair amount” of confidence: That same poll found that scientists are among America’s most trusted groups — even better trusted than the military! In fact, Americans trust scientists more than people in most other countries do. Other polls show that although Republican trust in science has dropped somewhat, Republican support for spending more on science remains very strong: A Pew poll in 2023 found the exact same thing: So when MAGA types tell you about scientists losing their credibility, or a drop in trust in science, they’re only talking about themselves. Whatever left-wing politicization of science happened during the Biden administration — and there was definitely some of that — it was not enough to make most Republicans lose faith in the scientific enterprise, or favor research cuts in order to purge unwanted ideology from the system. That doesn’t mean I think progressives should continue down the path of politicizing scientific research. They should not, and Biden made real missteps in this area. Objectivity clearly matters for public trust of science in the long term. But as of right now, there’s no crisis of trust in science, except among the smallish minority of people who are running around screaming that there’s a crisis of trust in science. But despite science’s overwhelming popularity and public trust, Trump and his administration are launching an unprecedented and devastating attack on American science — cutting funding, and forcing science projects to undergo ideological review by government commissars. Trump’s comprehensive attack on science
7 Types of Magnesium and What Each Is Used For
From glycinate for sleep to citrate for constipation, experts explain how common magnesium forms differ, who may benefit, and why it's important to talk to a health care provider.
6 hidden Samsung dial codes that unlock secret features on your Galaxy phone
Every Samsung phone has secret cheat codes, and it's a shame that more people don't know about them. Type these and see what happens.
One Type Of Screen Time May Actually Benefit Your Brain, New Study Finds
Turns out, some screen time may actually be good for your brain.
Oregon pushes mpox vaccines as more serious type of virus spreads
Community transmission of a more serious type of mpox virus is increasing in several countries. Here's what health officials want Oregonians to know.
UAB Launches EA Sports College Football 27 Dynasty Challenge
BIRMINGHAM – Think you have what it takes to lead the Blazers to college football glory? With the release of EA SPORTS College Football 27, UAB Athletics is ...
Entertainment around the area
Alison Krauss & Union Station, whose latest album “Arcadia” arrived in 2025, lead the entertainment coming to local and regional venues over the next couple of weeks. The bluegrass/country act, kn...
Sugar substitutes are low in calories, but may disrupt your metabolism, study says
Artificial sweeteners also may increase risk of type 2 diabetes and heart disease, the research shows.
Julian Barzilli - Senior Associate Athletic Director for Finance and Business Operations
Julian Barzilli is entering his first season at Tarleton State as Senior Associate Athletic Director
Football Hauls in 14 Selections to Athlon Sports Preseason All-CUSA Team
MIAMI — FIU's football program received a total of 14 student-athletes named to the 2026 Preseason All-CUSA Team, as released by Athlon Sports.
Marshall Football Has 12 Players Honored By Athlon Sports
Marshall Football had 12 players recognized by Athlon Sports as 2026 Preseason All-Sun Belt Conference selections, the magazine released recently. The Thunde...
Michigan State to Play Arkansas in 2026 CBS Sports Thanksgiving Classic in Detroit
East Lansing, Mich. – Michigan State's men's basketball team will face the University of Arkansas for the second-straight year in a non-conference game, this...
DiDomizio Named College Sports Communicators 2nd Team Academic All-American
GREENWOOD, Ind. – On Wednesday, the College Sports Communicators (CSC) Academic All-America At-Large teams were announced with graduate student Nick DiDomizio (Cheshire, Conn.) being named as a 2nd Team Academic All-American.
DePaul Athletics and Playfly Sports Enter Multimedia Rights Partnership
CHICAGO, IL / NEW YORK, NY, July 8, 2026 – DePaul University Athletics and Playfly Sports, the sports industry's leading revenue maximization company, today ...
Explaining The Comcast and NBCUniversal Divorce
(Welcome to the “Most Important Story of the Week”, my bi-weekly strategy column analyzing the most important (but often not buzziest) news story of the last two weeks. I’m the Entertainment Strategy Guy, a former streaming executive who now analyzes business strategy in the entertainment industry. Please subscribe.) I hope everyone had a happy Fourth of July in America, celebrating the country’s 250th birthday. Frankly, I am bummed the 250th wasn’t a bigger celebration, but that’s a different topic for a different Substack. While it was generally a quiet week on the entertainment/streaming/media business fronts, we still had some interesting news stories. Actually, that kinda undersells one of the stories, a huge, huge, huge divestment that could upend the entertainment landscape... So let’s get right to it. In today’s column, I’ll cover Comcast spinning off the rest of NBCUniversal, an entertainment company investing in an LLM company and an LLM-owner investing in a movie studio, the latest round of threats of digital tariffs, and more. Let’s dive in. Subscribe Most Important Story of the Week - Most: Comcast/NBCU Breakup!!!! If I had to describe my reaction to Comcast spinning out NBCUniversal, it feels like a relationship ending, either breaking up or divorcing. Comcast’s decision to spin off the rest of NBCUniversal, after spinning off some of its cable assets into Versant last year, really does feel like a family breaking up under “irreconcilable differences”. Of my stereotypes of the entertainment moguls, my go-to for Comcast CEO Brian Roberts—heir to the Comcast fortune, but a man who’s been at the helm for 24 years now, and president for twelve years before that—is that he likes building empires. He cut his teeth acquiring cable rivals in the 1990s and tried to buy Disney repeatedly, then settled for NBCUniversal after a long court battle. (Contrast this with Rupert Murdoch, a man who also loved to buy, but would also sell when the price is right. Murdoch made Fox out of nothing, but then sold 20th Century Fox to Disney, arguably at the top of the market. So I understood why he sold.) But I don’t understand Roberts’ motivation to sell now. I have some explanations but no single, super-satisfying explanation. Strategically, it would just make more sense to have kept NBCUniversal in-house, especially for a one-time empire builder like Comcast. Yet one powerful force—arguably the decider in modern capitalism—likely overwhelmed all other considerations. At first, I thought I’d arrange my thoughts as a “Five Why” analysis, digging through each layer of the puzzle. But instead, I found myself asking, “But…why?” (And I only ended up with four sections.) So let’s look at Comcast from that angle. Then, at the end, I’ll give my biggest strategic recommendation for every company in Hollywood. It’s obvious, but sometimes, the obvious strategy is the most ignored. But…Why? The Stock Market, Conglomerations, and Sum of the Parts Analysis We’re just getting started with this issue, but the rest is for paid subscribers of the Entertainment Strategy Guy, so if you’d like to find out… Why Comcast could never get a “tech company” valuation The not-so-secret motivation for Comcast What Versant has to do with all of this The key strategic advice I think every entertainment exec should follow (though it’s really obvious) Some big AI investment news… Whether we’ll see digital tariffs… And more… ...please subscribe! We can only keep doing this great work with your support.
16 Owls Selected to Athlon Sports’ Preseason All-CUSA
KENNESAW, Ga. – Kennesaw State football continued to receive preseason honors as Athlon Sports announced a whopping 16 preseason all-Conference USA selections for the Owls this week.
How do the Orioles get more Blaze Alexanders?
The breakout infielder exemplifies the type of player the O’s should look to add at this year’s trade deadline.
Beanblossom Named College Sports Communicators Academic All-America
WASHU ACADEMIC ALL-AMERICANS
NDSU Announces EA Sports College Football 27 High Roller Challenge
FARGO, N.D. – North Dakota State University is embarking upon its first season of FBS football with the EA Sports College Football 27 High Roller Challenge. ...
Musk Calls It 'Utterly False,' But This SpaceX Rumor Should Terrify Every Apple Investor
Shares of Apple (NASDAQ:AAPL | AAPL Price Prediction) rose 1.7% on July 1, 2026, the day the Wall Street Journal reported that SpaceX had shown IPO investors a prototype handset: slimmer than an iPhone, running a proprietary operating system, powered by a Qualcomm Snapdragon chip, and deeply integrated with xAI’s Grok. Elon Musk called the ... Musk Calls It ‘Utterly False,’ But This SpaceX Rumor Should Terrify Every Apple Investor
Church services dull pain, and a new diabetes drug: science stories of the week
From new types of spider hunting techniques to the earliest-known plague victims, here are the most interesting recent scientific developments
Six Chanticleers Named to Athlon Sports Preseason All-Sun Belt Team
CONWAY, S.C. – Six Coastal Carolina football players were named to the Athlon Sports Preseason All-Sun Belt Team, the publication announced.
TSU HOF Class of 2026: Johnny "Ballpark" Franks
Throughout the summer months leading up to the Tennessee State University Athletics Hall of Fame Banquet on Aug. 27, Tennessee State Athletics will highlight the members of the Hall of Fame Class of 2026. This distinguished group of former student-athletes, coaches, administrators and contributors helped shape the proud tradition of Tiger athletics through championship performances, individual achievements and lasting contributions to the university. Their stories reflect the excellence, perseverance and impact that have defined Tennessee State Athletics across generations.
Researchers in Switzerland invent a new type of pixel
Pixels either control light or analyze it. This one does both.
FULL SHOW: Inside INdiana Business 7/5/26
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Dangers of youth using AI for mental health care
A nationwide study finds more and more teens are using A-I to replace mental health professionals. It’s led to some scary outcomes, even tragic endings. NBC 7’s Shandel Menezes sat down with some teens to hear what type of support they need.
10 More Amazing Indie Games To Wishlist This Indie-Penance Day
An exquisite array of games of every type, packed with invention and originality
Digital diabetes tool shown to improve patient care and cut health care costs
A new study by University of Manchester researchers has linked a digital platform helping people manage type 2 diabetes to better blood sugar control, improved health and potential long-term NHS cost ...
Health or Hoax?
Although GLP-1s may cultivate confidence and belonging among gay and bisexual men, they can also reinforce idealized body types that can be unhealthy and socially exclusionary.
Eleven Pirates Named Preseason All-Conference By Athlon Sports
GREENVILLE, N.C. – Eleven East Carolina football player have been named to preseason All-American Conference Teams according to an announcement by Athlon Spo...
12 Hilltoppers Named To Athlon Sports 2026 Preseason All-CUSA Team
BOWLING GREEN, Ky. – WKU Football had 12 players recognized on the Athlon Sports 2026 Preseason All-Conference USA Team.
Camera-Equipped AirPods Pro Development 'Suspended,' Leaker Claims
Development of Apple's rumored camera-equipped AirPods Pro has been halted, according to the leaker and prototype collector known as "Kosutami". In a blunt post on X referencing an earlier post about the product, the occasional leaker claimed that the project has been "suspended". No other details were provided.
Comparative Analysis of every Water Starter in Pokémon GO
With Sobble Community Day, Pokémon GO trainers will have every single available -type starter in the franchise with their exclusive Community Day moves, obviously until Pokémon Winds and Waves debuts the undeniably cool Gecqua. Sporting the powerful Hydro Cannon, these Pokémon are known for creating waves in the meta, quite literally! But with types being […]
‘Explosive Diarrhea Parasite’ Sickens 170 in Michigan, Hospitalizes At Least 20 Nationwide
Cyclosporiasis is a type of food poisoning that can cause severe diarrheal illness, but it is not usually life-threatening. The latest spike in Michigan has health officials on high alert.
The real cause of a common stroke may have been missed for decades
Scientists have discovered that a common type of stroke may have a very different cause than doctors once thought. Instead of fatty plaque clogging arteries, the strongest link was found with enlarged and damaged blood vessels deep within the brain. The finding helps explain why standard treatments like aspirin are often less effective and is driving the search for new therapies that target the brain’s tiny blood vessels directly.
A new attack uses a BioShock-style puzzle to convince AI browsers they're not in the real world
Researchers from LayerX recently unveiled BioShocking, a new type of vulnerability designed to target AI-powered browsers capable of executing autonomous tasks on the open web. The security...
Feds pull Iowa's 'healthy food' SNAP waiver
A federal waiver allowing Iowa to restrict the types of food that can be purchased with SNAP has been vacated.
4 Business Essentials You Can’t Ignore If You Want to Be a Successful Entrepreneur
Here are four critical business essentials every owner should have in place no matter the size or type of business they have.
Eight Golden Flashes Named to Athlon Sports 2026 Preseason All-MAC Teams
KENT, Ohio — Kent State football placed eight players on Athlon Sports' 2026 Preseason All-MAC Teams, the publication announced as part of its 2026 College F...
Track & Field Alum Pablo Almaguer Celebrates Induction into RGV Sports Hall of Fame
RIO GRANDE VALLEY – The week of Pablo Almaguer's induction into the Rio Grande Valley Sports Hall of Fame for his success as the head girls track & field and cross country coach at Weslaco High School, he was asked if he ever envisioned such an honor coming his way.
30 Crusaders Named Arthur Ashe, Jr. Sports Scholars
WORCESTER, Mass. – The College of the Holy Cross had 30 student-athletes named 2026 Arthur Ashe, Jr. Sports Scholars, honoring their athletic and academic achievements. The awards were announced in the June 8 issue of Diverse: Issues in Higher Education magazine. Leading the way was senior Julian Beban of the men's soccer team, who was one of 10 national finalists for the men's Sports Scholar of the Year award. Beban was also joined by senior Julian Jenkins (men's lacrosse) and senior Emma Tweed (women's rowing) as the top honorees in their respective sports.
The Fat ‘Upgrade’ A Doctor Recommends To Lower Bad Cholesterol
In TODAY.com’s Expert Tip of the Day, a doctor explains why we need fat and how to choose the best type for heart health.
Smith Named CAA Leadership and Sports Excellence Award Winner for Swimming & Diving
RICHMOND, Va. - Drexel's Sebastian Smith has been named one of the 19 recipients of the prestigious CAA Leadership and Sport Excellence Award for the 2025-26...
Sobble Community Day: Your Go-To PvE Guide
Sobble Community Day makes Inteleon a strong Water-type raid attacker with Hydro Cannon and a valuable future pick for Max Battles.
Elon Musk denies a report about SpaceX’s AI phone prototype
Musk says the report is “utterly false.”
Musk denies WSJ report that SpaceX showed AI handset prototype before IPO
Elon Musk on Wednesday denied a Wall Street Journal report that SpaceX showed investors and other stakeholders a prototype of an AI-focused device ahead of its blockbuster IPO.
SpaceX has an AI device prototype, and it sure sounds phone-ish
SpaceX reportedly showed investors a "handset-like" AI device before going public. It could be another signal SpaceX wants to expand into wireless.
Flood Hired as MBB Sports Data Analyst
Aidan Flood '26, a former data intern with the Syracuse men's basketball program, has joined the staff as sports data analyst.
Thomas, Hurst Headline Athlon Sports Preseason Awards
Wide receiver Amare Thomas and offensive lineman Shadre Hurst were Houston Football's two Athlon Sports Preseason All-America Third-Team selections announced...
Four Eagles Named to Athlon Sports Preseason ACC All-Conference Team
Chudzinski, Price highlight list with second-team recognition
2026-27 Season Tickets for LMU Fall and Winter Sports Now on Sale
LMU Athletics has announced that season tickets for all 2026-27 fall and winter sports are now on sale, with packages available for men's and women's soccer, women's volleyball, and men's and women's basketball.
Unisun Sports Commences, Kicking Off 2026-27 Season
JACKSONVILLE, Fla. - Unisun Sports, the groundbreaking strategic alliance between the Atlantic Sun Conference (ASUN) and the United Athletic Conference (UAC), has officially commenced as of July 1, 2026. Unisun Sports will serve both conferences, designed to significantly enhance operational efficiency, foster deeper collaboration, and drive innovation across both NCAA Division I organizations.
Unisun Sports Commences, Kicking Off 2026-27 Season
Unisun Sports, the groundbreaking strategic alliance between the Atlantic Sun Conference (ASUN) and the United Athletic Conference (UAC), has officially commenced as of July 1, 2026. Unisun Sports will serve both conferences, designed to significantly enhance operational efficiency, foster deeper collaboration, and drive innovation across both NCAA Division I organizations.
Fish named after Blackpink’s Jennie; China’s 6G smart city: 7 science highlights
From two Chinese scientists leaving the US to a desalination prototype, here are some highlights from SCMP’s recent science reporting.
Can GLP-1 medications improve health in people with Type 2 diabetes and PAD?
Research Highlights: GLP-1RA (glucagon-like peptide-1 receptor agonist) medications, which are prescribed to treat Type 2 diabetes and to help with weight loss, were found to reduce the number of deaths, amputations and hospitalizations among people...
SCSU Athletics Features 21 Owls To Receive NE10 Presidents' Award for Sports Excellence
NEW HAVEN, Conn. - Southern Connecticut State University Athletics featured 21 graduating student-athletes to receive the Northeast 10 Conference's Presidents' Award, as announced by the conference on June 30, 2026.
Six Terps Earn Preseason All-Big Ten Recognition from Athlon Sports
Six Maryland football student-athletes have been recognized on the Athlon Sports Preseason All-Big Ten Team, led by first-team selections Daniel Wingate and ...
"We're talking about at least half a decade of horror": former Exodus lead explains why he wasn't keen on doing a Baldur's Gate 4 despite Hasbro offering the chance
After Larian opted against a Baldur's Gate 4, Hasbro asked Archetype Entertainment head James Ohlen if he fancied a crack at it and he wasn't keen.
Why Girls In Sports May Be More Likely To Lead, And How Coaches Help
94% of C-suite women played sports as youth. There is one type of leader that has a big impact on whether girls want to play and stay in sports: The coach.
This Simple Nightly Ritual Improves Nail Health
A dermatologist explains the benefits of nail oiling, as well as which types work best and how often you should apply them.
FDA approves surgical device for high-risk aortic procedures
The AMDS Hybrid Prosthesis was designed to help clinicians treat DeBakey Type 1 dissections complicated by malperfusion. It works as a complement to hemiarch replacement, preserving the native arch and making reinterventions possible if needed.
Hands On: R-Type Tactics I • II Cosmos - How Does This Turn-Based PSP Pair Hold Up On Switch?
It's a bold strategy Cotton
Apple Acquires Award-Winning App 'Play'
In February, Apple notified the European Commission that it would be acquiring certain assets from and have the right to hire certain employees from Rabbit 3 Times, the company behind the award-winning app design tool Play. The notification was published on the European Commission's website this week, following a four-month waiting period. Play was a Mac and iPhone app that allowed designers to prototype iPhone app interfaces using Apple's SwiftUI frameworks, and then send them to Xcode.
Nhouyvanisvong, Green Among Attendees at NCAA Career in Sports Forum
Macalester College rising senior Adi Nhouyvanisvong (Wayata, Minn./Minnetonka) of the women's soccer team and rising junior Jay Green (Roseville, Minn./Mounds Park Academy) attended the NCAA's Career in Sports Forum, held May 27-30 at the NCAA headquarters in Indianapolis, Ind.
Millions of exploding stars could soon reveal dark energy's secrets
A new AI-powered framework could transform how astronomers measure the expansion of the Universe. By analyzing images of Type Ia supernovae and modeling their environments in unprecedented detail, researchers can estimate cosmic distances with near-spectroscopic accuracy. The technique is designed for the flood of data expected from the upcoming Vera C. Rubin Observatory and may greatly improve our understanding of dark energy.
OSU rolls to most lopsided all-sports Bedlam Series win on record
STILLWATER – For the sixth time in the last seven years and for the 11th time in the last 13 years, Oklahoma State has won the all-sports Bedlam Series over ...
From invention to impact: Hong Kong Science Fair gives young innovators a wider stage
Organised by the Hong Kong Innovation Foundation, with Sino Group as Principal Patron and the Innovation, Technology and Industry Bureau as Supporting Bureau, the Fifth Hong Kong Science Fair has drawn to a close. Students are already looking beyond their prototypes, with international exchanges and future applications now firmly in sight.
Design and Early Implementation Outcomes of a Mobile Health-Enabled Social Support Intervention for Adults Living With HIV and Type 2 Diabetes in Uganda
Background: Adults living with HIV and type 2 diabetes experience complex treatment demands that affect medication-taking, clinic attendance, privacy, social support, and engagement with care. M...
The 5 Healthiest Fats You Can Eat
Fat has historically been demonized, but some types can be good for you.
Emily Wilcox Named Assistant Athletic Director for Sports Communications
Emily Wilcox has been named Assistant Athletic Director for Sports Communications. Her first day is slated for July 13.
College Sports Communicators Recognize Strelow with Writing Awards
BOONE, N.C. — App State's award-winning strategic communications staff added more honors this spring, as Bret Strelow was recognized for two stories in the Fred Stabley Sr. Writing Contest that's conducted by the College Sports Communicators organization.
Is Mega Skarmory good for Pokémon GO Raids?
Super Mega Skarmory Raid Day brings one of the new Legends: Z-A Mega Evolutions to Pokémon GO, and gives the undeniably cool Skarmory a new lease of life in the Raids meta. A popular / type from Gen 2, Skarmory has been a staple in the Little and Great League formats, but has never made […]
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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David P. O'Brien
About five years ago, David P. O'Brien had a comfortable position at Marsh & McLennan Cos., where he held the top post at the financial giant's Louisville, Ky., office. Despite the lofty rank, Mr. O'Brien found himself longing to be at a smaller company that had to work a little harder to land business. That desire led him away from Kentucky five years ago and to Cleveland, where he serves as executive vice president at business insurance agency Oswald Cos. "I left Marsh before it was en vogue," he said, referring to layoffs and defections at Marsh over the course of this year that followed accusations of bid rigging at the big firm. Above all, Mr. O'Brien, 38, wanted to work at a company that relied on its inventiveness, rather than its name, for business. He said he has found that at Oswald. "It causes you to be more creative, to be more resourceful," Mr. O'Brien said. For instance, an Oswald client seeking to do business internationally might be directed to the network of offices abroad run by competitors such as Marsh and Aon Risk Services Inc. "We're going to use whatever access into the market that makes the most sense for our clients," he said. Of course, using such a strategy can be dangerous for Oswald if its client decides to further a business relationship with one of the firms Oswald recommended. "That's the obvious question and why it's nontraditional," he said. "I think if we're good, and if we're bringing value to the client, then there's no risk. I'm not threatened by it." Imaginative business solutions of that type made his career move to Oswald from Marsh worthwhile. "It's very much a challenge," he said. "It helps you keep your edge. I'm all for the competition." John Jacunski, currently vice president and corporate controller at York, Pa., paper company PH Gladfelter Co., met Mr. O'Brien four years ago when Mr. Jacunski was at WCI Steel Inc. in Warren. So impressed was he with Mr. O'Brien's work for WCI that Mr. Jacunski has retained the Oswald executive at PH Gladfelter. "He's a young guy for the position he has, but he's done a great job for us," Mr. Jacunski said. Among his roles at Oswald, Mr. O'Brien leads the firm's client retention efforts and also serves as director of its property and casualty group. "You don't have the same human resources," he said of the job jump to Oswald. "You don't have, obviously, the safety net a big company has." But sometimes, it can be difficult to ascertain individual contributions when working at a big company. "I wanted to be able to see the end results of my work and my efforts," Mr. O'Brien said.
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How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
Keiser's Paul Dodson Voted 2025-26 SUN Sports Information Director of the Year
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