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Hendrix College President Karen Petersen named Business Executive of the Year by Conway Area Chamber of Commerce
March 25, 2026 – The Conway Area Chamber of Commerce has named Hendrix College President Dr. Karen Petersen as its Business Executive of the Year. The prestigious award recognizes leadership that drives institutional excellence while fostering significant economic and community growth within the region.
UNC basketball has always leaned into tradition, should honor it in coaching search
The Tar Heels have one name that's not the top candidate pundits will throw out, but he just may be the best fit at a place where tradition matters.
Quantum science outreach program sees Golden State expansion
Since its creation in 2022, SparCQS has introduced thousands of individuals to the not-so-small world of quantum science. Housed within the Center for Materials Interfaces in Research and Access (¡MIRA!), the workforce development initiative, whose name is an acronym for Sparking Curiosity in Quantum Science, delivers a trailer’s worth of colorful, approachable quantum science demonstrations to K-12…
Mamdani names pick to lead new Office of Street Vendor Services
She previously served as co-director of the Street Vendor Project.
18 Fort Collins-area athletes earn all-state honors for winter sports
18 Fort Collins-area high school athletes earned winter all-state honors, including three who were named Player of the Year in their sport and class.
NYC Health + Hospitals/Elmhurst's Mateo Espinosa Named to National Minority Quality Forum's "40 Under 40 Leaders in Minority Health" - NYC Health + Hospitals
NYC Health + Hospitals/Elmhurst is proud to announce that Mateo Espinosa, Assistant Director for Special Projects and Research in Ambulatory Care
Duke University Health System names new CEO
Dr. David Zaas will return to Duke University Health System as its new CEO effective May 1. He brings experience from his recent leadership roles at Atrium Health Wake Forest Baptist and MUSC Health.
March Madness 2026: CBS Sports sets viewership records during most-watched first NCAA Tournament weekend ever
The NCAA Tournament delivered on action during its first weekend, and viewers were tuning in by the droves
UC Berkeley researcher Sathvik Iyengar named 2026 Schmidt Science Fellow
Prestigious international fellowship recognizes emerging interdisciplinary science leaders
March Madness 2026: Our experts reset their NCAA Tournament brackets with updated picks heading into Sweet 16
If your bracket is busted, you are not alone, so here's what our experts would do if given a chance to reset their predictions
A leadership vacuum adds to strains on the CDC
Low morale, staff turnover and budget issues have sapped the Centers for Disease Control and Prevention. The administration is expected to soon name a new director, who will have their hands full.
Covenant Health Park named among best US ballparks. See the rankings
Its another home run for the Smokies ⚾
NASA Awards Astrophysics Postdoctoral Fellowships for 2026
The highly competitive NASA Hubble Fellowship Program (NHFP) recently named 24 new fellows to its 2026 class.
Mauricio Culebro named President of Soccer, AMB Sports and Entertainment
Former President of Tigres UANL takes the helm of MLS Atlanta United and launch of NWSL Atlanta in 2028
Mauricio Culebro named President of Soccer, AMB Sports and Entertainment
Former President of Tigres UANL takes the helm of MLS Atlanta United and launch of NWSL Atlanta in 2028
The right is openly divided over the Iran war as conservatives gather for CPAC
This year, neither Trump nor Vice President JD Vance has been publicly announced as speaking to the gathering. But among those who are slated to speak are big names in the MAGA movement who have voiced conflicting views on the Iran war.
2026 NCAA Tournament: How every Sweet 16 underdog can pull off an upset, reach Elite Eight
With only one double-digit seed still alive, there are plenty of toss-ups as the NCAA Tournament hits the Sweet 16
Trump names tech titans to science advisory council
President Donald Trump on Wednesday named some of the biggest names in US technology to his Council of Advisors on Science and Technology, assembling a roster that includes Meta founder Mark Zuckerber...
Amusement Entertainment Management Client Wins 2026 FEC of the Year
Star Lanes Polaris of Columbus, Ohio proudly accepted The American Amusement Machine Association’s (AAMA) 2026 Family Entertainment Center Location of the Year Award during the AAMA President…
Glyphosate: A story of science, risk, and nuance
In the summer of 2014, a California groundskeeper named Dewayne Johnson started noticing patches of raw, weeping skin spreading across his body. He had spent years applying Roundup, Monsanto’s glyphosate-based herbicide, for a school district, sometimes drenched in it when equipment malfunctioned. By 2014, he had a diagnosis: non-Hodgkin’s lymphoma. In 2018, a jury awarded him $289 million in damages, later reduced on appeal. Tens of thousands of lawsuits followed. The story hasn’t quieted down. It’s all over the internet, swinging between “this will kill you, buy organic” and “relax, you’re fear-mongering.” Some of that recent chatter stems from an Executive Order protecting glyphosate and its production, which set off intense infighting within the MAHA movement. Some of it reflects a deeper truth: Americans genuinely care about harmful chemicals in their environment (see poll below). And the conversation isn’t going anywhere, with a Supreme Court case involving Monsanto set for this April. Glyphosate (the active ingredient in Roundup) is one of the most widely used herbicides in the world. But does glyphosate cause cancer? And how much exposure is actually risky? With so much mistrust in institutions and corporations (and some genuine conflicts of interest), making sense of the actual scientific evidence is genuinely hard. Here is a translation of what the scientific evidence actually says. Does glyphosate cause harm? Glyphosate is an herbicide that kills most plants it contacts rather than targeting specific species. It works by blocking an enzyme pathway (EPSPS) that plants and many microorganisms need to produce essential amino acids. Without those amino acids, the plant can’t grow and dies. Glyphosate was first developed by Monsanto in the 1970s and became ubiquitous after the company introduced “Roundup Ready” crops in the 1990s. In 2024, Bayer removed glyphosate from residential Roundup-branded products due to litigation pressure. But today it is still the most widely used herbicide in the world. Farmers also discovered they could spray it directly on crops like oats, lentils, beans, and peas just before harvest to dry them out faster and make harvesting easier. Because of its widespread use, it’s obviously really important to understand if it’s harmful to humans. The key principle: The dose makes the poison The most important concept in toxicology is that “the dose makes the poison.” Sixteenth-century physician Paracelsus articulated what remains the foundational principle of toxicology: sola dosis facit venenum. Water will kill you if you drink enough of it. Aspirin saves lives at 81 milligrams and causes internal bleeding at higher chronic doses. So, at what dose is glyphosate poisonous? The LD50 in rats (the dose that kills half the test animals) is around 5,600 mg/kg body weight. Table salt is roughly 3,000 mg/kg. By that classic measure, glyphosate is less acutely toxic than salt. But some people are exposed to a lot of glyphosate through their work. And among the general public, there are many questions about low-dose, cumulative exposure from multiple sources over long periods. Does glyphosate cause health problems? Cancer Correlation maps are striking, with one analysis finding that 60% of counties that spray the most glyphosate have non-Hodgkin’s lymphoma rates above the national average. But correlation alone doesn’t establish cause, which is why animal and human studies matter. In animals: Rat studies are typically what most fear is rooted in, but most people don’t know the study details on the dosage given to rats. A pooled analysis of the 13 most rigorous rat studies found evidence that very high doses, around 55,000 times greater than typical food residue exposure, can cause certain cancers. In humans: One of the strongest studies followed 55,000 herbicide users over 20 years and found no overall increased cancer risk. There was one signal: among those with the highest use, rates of acute myeloid leukemia (AML) appeared elevated. A broader meta-analysis of 18 human studies also found no overall cancer risk, though a separate meta-analysis focused specifically on non-Hodgkin lymphoma found that people with high cumulative glyphosate exposure faced a 41% higher relative risk compared to those with low or no exposure. These human studies are observational studies (randomized controlled trials would be unethical), and meta-analyses are only as reliable as the studies they pool. But the story seems consistent: at very high exposure levels, there may be some cancer risk. But that’s about as far as the science currently takes us. Emerging research: gut and reproductive health Gut: Because glyphosate targets a pathway that exists in some gut bacteria, scientists have questioned whether it could affect the microbiome. In mice, a 2023 University of Iowa study found that glyphosate altered gut bacterial composition and raised markers of intestinal inflammation. A 2024 systematic review found similar patterns: disrupted gut bacteria and problems with the mucus layer that protects the intestinal wall in mice. Whether this translates to humans is an open question. The human gut is highly variable and resistant, and we don't yet have strong studies confirming the same effects in people. Reproductive health: Animal studies have found that glyphosate-based herbicides can interfere with reproductive hormones, including disrupting egg cell development in mice and reducing the number of eggs available in sheep’s ovaries. However, the doses used in these experiments were high, so it’s not yet clear whether the same effects would occur in humans. On the human side, a 2021 pilot study led by Mount Sinai researchers tested urine samples from pregnant women across the U.S. and found glyphosate in 95% of them. The study also found a possible connection between higher glyphosate exposure during pregnancy and a subtle physical difference measured in female newborns. That said, some connections weren’t statistically reliable and this was a small study. The researchers themselves said more and larger studies are needed before drawing firm conclusions. What do regulators say about glyphosate safety? In 2015, the International Agency for Research on Cancer (IARC), part of the World Health Organization, classified glyphosate as "probably carcinogenic to humans" (Group 2A). The classification is worth taking seriously. But, there’s an important distinction: IARC classifies hazard, meaning the potential to cause harm under some conditions. It does not assess risk, which accounts for actual exposure levels and the real-world probability of harm. The U.S. EPA, the European Food Safety Authority, Health Canada, and regulatory agencies in Australia and Japan have all concluded that glyphosate is “unlikely to be carcinogenic to humans” at realistic exposure levels. They’re asking a different question: given how much of this people actually encounter, what is the probability of harm? Your actual exposure is what determines your actual risk. What does glyphosate mean for your daily life? At the grocery store: Food residues are small. The EPA’s acceptable daily intake is 1.75 mg/kg of body weight per day. To hit that threshold from oatmeal alone, a 150-pound adult would need to eat roughly 50 pounds of oats every day. But this calculation addresses only one pathway (food), and we don’t yet have robust tools to measure people’s actual total exposure. If reducing exposure matters to you, organic certification prohibits synthetic herbicides, and organic oat products generally test at lower or undetectable levels. Either way, a diet rich in whole grains, conventional or organic, is far better for your health than one that omits them out of fear of residues. On the farm: Occupational exposure is orders of magnitude higher than consumer exposure. Farmers and farm workers who mix, load, and apply glyphosate-based herbicides, especially without protective equipment, face meaningfully different risk profiles. Proper PPE isn’t optional. Integrated weed management strategies that rotate chemical modes of action are also worth taking seriously, both for health and for long-term effectiveness. If you live near a farm: Spray drift is real. Concentrations near field edges can spike during and after application, particularly on windy days. This is an area where I think public health could really step up and empower rural communities with buffer zones, rather than placing the onus on individuals. But for now, knowing your local agricultural calendar and keeping windows closed during application are the first steps. Bottom line Dewayne Johnson was exposed to glyphosate at levels most people will never encounter, and a jury decided he deserved compensation. That outcome is not evidence that the oatmeal in your pantry is dangerous. But it is a reminder that the dose, the context, and the person doing the exposing all matter enormously. Glyphosate is a chemical tool with benefits, trade-offs, and genuine open scientific questions. Learning to hold that complexity without collapsing into panic or dismissal is, honestly, one of the most useful and hardest things to do in navigating modern health science. Love, YLE Your Local Epidemiologist (YLE) is founded and operated by Dr. Katelyn Jetelina, MPH PhD—an epidemiologist, wife, and mom of two little girls. Hannah Totte, MPH, is an epidemiologist and YLE Community Manager. YLE reaches more than 425,000 people in over 132 countries with one goal: “Translate” the ever-evolving public health science so that people will be well-equipped to make evidence-based decisions. This newsletter is free to everyone, thanks to the generous support of fellow YLE community members. To support the effort, subscribe or upgrade below: Subscribe
Trump names Jensen Huang, Mark Zuckerberg to 13-member science and tech council
Trump has made securing U.S. leadership in artificial intelligence a central priority of his second term.
Trump to name Zuckerberg, Ellison, Huang to tech panel, WSJ reports
U.S. President Donald Trump plans to appoint Meta Platforms CEO Mark Zuckerberg, Oracle Executive Chairman Larry Ellison and Nvidia CEO Jensen Huang to a panel that weighs in on AI policy and other issues, WSJ reported on Wednesday
Exclusive | Trump to Name Mark Zuckerberg, Larry Ellison and Jensen Huang to Tech Panel
The President’s Council of Advisors on Science and Technology is to weigh in on policies affecting the development of AI.
People moves: Allen Lo leaves Meta and joins Madison Square Garden Entertainment
Madison Square Garden Entertainment and Sphere Entertainment have announced that Allen Lo has been named EVP,
Rep. Fischbach Honored as Small Business Deduction Champion by NFIB
(KNSI) - Minnesota's Seventh District Congresswoman Michelle Fischbach has been named a Small Business Deducti...
UM Health-Sparrow honored for organ, tissue donation impact
University of Michigan Health-Sparrow will receive an award Wednesday for its efforts in giving patients a second chance at life through organ and tissue donation.
Iowa State vs Tennessee prediction, analysis, Sweet 16 expert picks for men's March Madness
Our March Madness experts analyze the Sweet 16 matchup between No. 2 Iowa State vs No. 6 Tennessee in the 2026 NCAA Tournament on March 27.
DeForest Yards developer looks to add a hotel to mixed-use housing and entertainment district
Developers for an upcoming mixed-use housing and entertainment district in DeForest are looking to adding a hotel to their plans
Hubert Davis out as UNC coach after five years, ushering in historic break from Carolina family tradition
A stunning NCAA Tournament collapse, eroding donor support and mounting internal pressure culminated in North Carolina cutting ties, a move that breaks the program's 70-year coaching lineage
Long lines persist at some U.S. airports despite ICE arrival
The Trump administration’s deployment of ICE officers to more than a dozen U.S. airports appeared to have a limited effect on reducing security lines.
Confluence Health physician assistant recognized with statewide award
WENATCHEE — A Confluence Health clinician was named the Rural Physician Assistant of the Year earlier this month by the Washington Academy of Physician Assistants.
March Madness 2025: CBS Sports sets viewership records during most-watched first NCAA Tournament weekend ever
The NCAA Tournament delivered on action during its first weekend, and viewers were tuning in by the droves
Arkansas’ Goodwill leader shares business model goals - Talk Business & Politics
The CEO of Goodwill Industries of Arkansas Brian Marsh knows his nonprofit is practically a household name, but he’s hoping its work can change household incomes. Marsh sat down with...
Arkansas’ Goodwill leader shares business model goals - Talk Business & Politics
The CEO of Goodwill Industries of Arkansas Brian Marsh knows his nonprofit is practically a household name, but he’s hoping its work can change household incomes. Marsh sat down with...
NCAA Men's Basketball Tournament: Ranking the Sweet 16 Matchups
FOX Sports' Casey Jacobsen ranks the Sweet 16 matchups in the NCAA Men's Basketball Tournament.
Pop-up bar dedicated to women's sports now open in Boston
261 at Para Maria is named for the bib number worn by the first woman to officially run the Boston Marathon.
Prologue Entertainment Taps Ken Segna As Head Of Television Development
Prologue Entertainment, the indie studio behind Netflix thrillers Zero Day and A House of Dynamite, has named Ken Segna as Head of Television.
Kari Nadeau named dean of the UCLA Fielding School of Public Health
Nadeau, currently chair of environmental health at Harvard’s T.H. Chan School of Public Health, will begin her new role in July.
Jacobs Entertainment begins construction on downtown sports fields
Jacobs Entertainment has begun building the flat fields
Lowndes County leaders cut ribbon on medical, mental health jail expansion
The new facility includes 60 cells with a total of 90 beds, according to the county.
Seminoles’ McCray V and Steen Earn Academic All-District Honors as Named by College Sports Communicators
TALLAHASSEE – Florida State basketball standouts Robert McCray V and Alex Steen have been named Academic All-District honorees by the College Sports Communic...
12 Life Science Startups Named to SLAS Europe 2026 Innovation Showcase Program
SLAS has named the 12 companies selected to participate in its Innovation AveNEW program at the SLAS Europe 2026 Conference and Exhibition.
Kaus Earns College Sports Communicators Academic All-District Honors
ITHACA, N.Y. – Cornell women's basketball junior Rachel Kaus has been named to the College Sports Communicators (CSC) Academic All-District team, the organization announced on Tuesday.
Is it ‘Ih-ran’ or ‘E-ron’? Inside the politics of pronunciation
Both President Trump and Vice President Vance pronounce Iran as ‘Ih-RAN,’ not ‘Ih-RON.’ A linguist says that how the country’s name is pronounced may be a political choice.
Brown Named College Sports Communicators Academic All-District
Guard Malea Brown of the Longwood women's basketball team has been named to the 2025-26 Academic All-District® NCAA Division I women's basketball team as selected by the College Sports Communicators, the organization announced Tuesday.
Three Hawks Named to College Sports Communicators Women's Basketball Academic All-District Team
WEST HARTFORD, Conn. - On Tuesday, the College Sports Communicators (CSC) Academic All-District women's basketball teams were announced with three members of the Hartford volleyball team featured.
Parker Named to College Sports Communicators Academic All-District Team - University of Massachusetts Athletics
K'Jei Parker of the Massachusetts men's basketball team has been named to the College Sports Communicators Academic All-District Team, as announced on Tuesda...
Robins School of Business ranks as a Top 20 undergraduate business school
Poets&Quants for Undergrads has named the University of Richmond’s business school a top 20 school for the fifth consecutive year.
Cone Health Cardiologist Named 2026 RISE Health Care Hero
Dr. Kardie Tobb wins National Award
Steven Corcelli named William K. Warren Foundation Dean of the College of Science
Steven A. Corcelli, professor of chemistry and biochemistry at the University of Notre Dame, has been appointed the William K. Warren Foundation Dean of the College of Science by University President Rev. Robert A. Dowd, C.S.C., effective April 1. Corcelli, who has served as interim science dean since July, was selected through a comprehensive national search launched after his predecessor, Santiago Schnell, was appointed as Dartmouth’s provost.
4 Pitt people were named Pittsburgh Business Times 2026 Women of Influence
The awards recognize the region’s businesswomen, including one Pitt dean and three alumnae, who make impactful change by leading organizations.
March Madness top seeds dominate: Each No. 1 team's path to Sweet 16
Only one perfect 2026 Women's NCAA Tournament bracket remains as of Monday evening following several upsets, but the top seeds have been chalk.
Parolin Named to College Sports Communicators Academic All-District Team - Boise State University Athletics
Dominic Parolin has been named to the College Sports Communicators Academic All-District Team, it was announced on Tuesday.
Play the Tiny Takeover drop
Tiny Takeover has officially stormed Minecraft! New versions of baby mobs are causing cuteness overload across biomes and builds. Pack your golden dandelions, craft name tags, and get ready to collect, cuddle, and coo over our new tiny rascals.
Women's NCAA Tournament Round 2 winners, losers: Virginia make history, Iowa fizzles
USA TODAY has followed every upset, buzzer-beater and game from the 2026 Women's NCAA Tournament and rounded up our winners and losers from round two:
NCAA Tournament: Cinderella’s not ‘dead,’ she’s just sporting new threads
Cinderella entered the portal. Now she's built different.
Las Vegas talent agency grows as city’s entertainment market expands
As the city continues to grow, more opportunities are coming up for local models and actors.
Las Vegas talent agency grows as city’s entertainment market expands
As the city continues to grow, more opportunities are coming up for local models and actors.
Las Vegas talent agency grows as city’s entertainment market expands
As the city continues to grow, more opportunities are coming up for local models and actors.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Two-sport athlete Deron Russell gears up for state basketball tournament, but knows college football season isn't far away
Did Dana White want Nate Diaz back in UFC?
Former title contender Nate Diaz will return to MMA for a promotion not named UFC.
White House pitches pharma on pricing draft
Plus: Names of the candidates to lead the CDC
Manor Township Democratic committee person kicked off May 19 primary ballot
Kirk Barrett, a candidate for a Manor Township seat on the Lancaster County Democratic Committee, has successfully kicked the incumbent’s name off the ballot for the upcoming May 19 primary.
The Core Entertainment Hires Sarah Pfeiffer As Head Of Marketing & Gabriella Pulley As Chief Of Staff
The Core Entertainment is continuing to scale its company, with the recent news of two new hires added to the leadership team. Sarah Pfeiffer has been named
2026 NCAA Tournament second round schedule: March Madness bracket, game dates, tip times, TV channels
Check out the master schedule for the first and second rounds of the 2026 NCAA Tournament so you can watch all the March Madness
Women's March Madness results so far: Scores from Monday's NCAA Tournament
Three No. 1 seeds are in action today as the Women's NCAA Tournament whittles the field down to the Sweet 16. See who's primed to survive and advance.
Borussia Dortmund names second-division exec as sporting director
Borussia Dortmund has dipped into the German second division to appoint a new sporting director who won praise for making impactful transfers on a budget.
Ewing to announce entertainment for Omaha’s Memorial Park concert
The event is happening on Friday, June 26.
Ewing to announce entertainment for Omaha’s Memorial Park concert
The event is happening on Friday, June 26.
Saturn Gets 11 New Moons, Bringing Its Total To A Whopping 285 –66 Percent Of All The Solar System's Moons
There's actually a rule which stops these moons from being given proper names. Don't give them the attention.
From The Sports Desk: Cinderella’s rough weekend
Iowa knocked off the defending champions, Florida, in a rare upset over the weekend in the NCAA tournament.
Illinois, the youngest team in Women's NCAA tournament, proving age is just a number
No. 7 seed Illinois faces No. 2 seed Vanderbilt in Nashville in the second round of the Women's NCAA Tournament.
Vanderbilt’s historic gym takes center stage for Women's NCAA Tournament
Opening in 1952, Memorial Gymnasium is the oldest arena in the SEC. It had been 14 years since the Commodores last hosted the NCAA Tournament.
NCAA Tournament: Iowa's stunning upset of No. 1 Florida caps off thrilling weekend of March Madness
Only three of the four top seeds in the men’s bracket will be playing in the Sweet 16.
Scouting Michigan State basketball Sweet 16 matchup with UConn
Get a first glimpse at the NCAA Tournament East region Sweet 16 semifinal matchup between 3-seed Michigan State basketball and 2-seed UConn.
Ohio State vs Notre Dame predictions, picks, odds for NCAA Tournament Second Round
Our March Madness experts pick the winner for No. 3 Ohio State vs No. 6 Notre Dame in the 2026 women's NCAA Tournament on March 23
UConn vs Syracuse predictions, picks, odds for NCAA Tournament Second Round
Our March Madness experts pick the winner for No. 1 UConn vs No. 9 Syracuse in the 2026 women's NCAA Tournament on March 23
Where to watch South Carolina vs. USC in March Madness Second Round: Time, TV Channel
The No. 1 South Carolina Gamecocks face the 9 USC Trojans in the Second Round of the women's NCAA Tournament. Here's how to see all the action.
Florida dogs featured in TCPalm articles for National Puppy Day
National Puppy Day is March 23. TCPalm has articles, videos and photo galleries about dogs. Do you have a dog? What's their name?
Personnel note: Tampa Electric names Ed Narain as Director of Regional Affairs
'Tampa Electric has a long history of supporting the growth and success of the communities it serves, and I look forward to helping strengthen those partnerships.'
TCU completes comeback, avoids Washington's NCAA Tournament upset bid
TCU women's basketball’s 62-59 overtime win over Washington in the second round of March Madness wasn’t pretty, but it was resilient.
Winners and losers from first weekend of the NCAA tournament feature John Calipari, Darryn Peterson, Big Ten and blue bloods
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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