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Ask the Developer Vol. 21: Tomodachi Life: Living the Dream — Part 3 - News

This article has been translated from the original Japanese content. This interview was conducted before the game was released. In this 21st volume of Ask the Developer, an interview series in which developers convey in their own words Nintendo's th…

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Apr 14 • 8:00 AM EDT • Technology • nintendo.com
Ask the Developer Vol. 21: Tomodachi Life: Living the Dream — Part 1 - News

This article has been translated from the original Japanese content. This interview was conducted before the game was released. In this 21st volume of Ask the Developer, an interview series in which developers convey in their own words Nintendo's th…

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Apr 14 • 8:00 AM EDT • Technology • nintendo.com
Memorial Health Foundation fashion show raises over $142K

The Memorial Health Foundation 21st annual Fashion Show, this year with a Masquerade Ball theme, drew a large crowd and raised more than $142,000, with proceeds supporting local cancer patients and related health initiatives. The annual fundraiser supports the foundation’s cancer patient emergency fund and breast health initiatives, helping individuals undergoing treatment with expenses such […]

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Apr 12 • 8:00 PM EDT • Health • newsandsentinel.com
Memorial Health Foundation fashion show raises over $142K

The Memorial Health Foundation 21st annual Fashion Show, this year with a Masquerade Ball theme, drew a large crowd and raised more than $142,000, with proceeds supporting local cancer patients and related health initiatives. The annual fundraiser supports the foundation’s cancer patient emergency fund and breast health initiatives, helping individuals undergoing treatment with expenses such […]

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Apr 12 • 8:00 PM EDT • Health • mariettatimes.com
Leah Halton-Pope named Democratic candidate for 141st Assembly District

It comes after Crystal Peoples-Stokes announced this past week she would not seek reelection.

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Apr 12 • 6:29 PM EDT • Politics • spectrumlocalnews.com
Report: Hideo Kojima's Physint New Casting Details Unearthed, Teasing a Villain

Production on Kojima's return to action-espionage is gearing up, and we've unearthed brand new exclusive Physint casting details.

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Apr 12 • 11:14 AM EDT • Technology • mp1st.com
Memorial Health Foundation fashion show raises over $142K

The Memorial Health Foundation 21st annual Fashion Show, this year with a Masquerade Ball theme, drew a large crowd and raised more than $142,000, with proceeds supporting local cancer patients and related health initiatives. The annual fundraiser supports the foundation’s cancer patient emergency fund and breast health initiatives, helping individuals undergoing treatment with expenses such […]

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Apr 10 • 8:00 PM EDT • Health • mariettatimes.com
Cowboys should consider this offensive player in 1st round

Is there any way you would be okay with Dallas going offense in the first round?

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Apr 10 • 5:00 PM EDT • Sports • sports.yahoo.com
Will LeBron James play vs Suns? Lakers reveal injury report

Los Angeles Lakers superstar forward LeBron James will be available on Friday in their 81st contest of the season vs the Phoenix Suns.

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Apr 10 • 4:21 PM EDT • Sports • sports.yahoo.com
Pirates get 1st hit off Cubs' Thielbar in 7th inning after Imanaga departs

Shota Imanaga pitched six sharp innings for the Chicago Cubs before Ryan O’Hearn led off the seventh with a single to right off Caleb Thielbar for Pittsburgh’s first hit of the game | 97.3 The Sky

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Apr 10 • 3:55 PM EDT • Sports • audacy.com
1st-Round WR Enters Vikings Mock Draft Orbit

Will the Minnesota Vikings actually use their 1st-Round draft pick in two weeks on a wide receiver? Probably not. Can […]

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Apr 10 • 3:45 PM EDT • Sports • sports.yahoo.com
Dollywood discounts are here for the park and resorts. See who qualifies

Dolly Parton’s theme park has discount tickets and special rates for resort stays for community heroes. But the offer is only for a limited time.

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Apr 10 • 5:05 AM EDT • Entertainment • knoxnews.com
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Framework is teasing a lot of Linux for its April 21st event

“I use Arch btw”

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Apr 9 • 2:24 PM EDT • Technology • theverge.com
Dyson just released its 1st handheld fan in time for the summer heat

The first portable fan from premium brand Dyson costs less than $100.

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Apr 9 • 10:09 AM EDT • Technology • goodmorningamerica.com
Experts set 2030 nutrition science goals for resilient food systems

As the second quarter of the 21st century unfolds, experts are examining the state of nutrition as the UN Sustainable Development Goals (SDG) deadline looms with five years remaining. To achieve these targets, a new paper outlines key goals for nutrition science from 2025 to 2030. The Frontiers in Nutrition publication discusses the interconnectedness between nutrition, food security, and sustainability in complex food systems affected by shocks, policies, and environmental limits. The researchers reveal how these modern factors impact nutrition science and shape research agendas.

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Apr 9 • 8:04 AM EDT • Science • nutritioninsight.com
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Vilma Jää Brings herding calls and mocking songs to Met Opera’s production of 'Innocence'

Vilma Jää never expected to play a major role in one of the 21st century’s most acclaimed operas when she enrolled at the Sibelius Academy to study folk music | 1080 WTIC NEWSTALK

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Apr 9 • 1:21 AM EDT • Entertainment • audacy.com
Vilma Jää Brings herding calls and mocking songs to Met Opera’s production of 'Innocence'

Vilma Jää never expected to play a major role in one of the 21st century’s most acclaimed operas when she enrolled at the Sibelius Academy to study folk music | Talk Radio 1210 WPHT

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Apr 9 • 1:21 AM EDT • Entertainment • audacy.com
Vilma Jää Brings herding calls and mocking songs to Met Opera’s production of 'Innocence'

Vilma Jää never expected to play a major role in one of the 21st century’s most acclaimed operas when she enrolled at the Sibelius Academy to study folk music | KYW Newsradio

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Apr 9 • 1:21 AM EDT • Entertainment • audacy.com
Vilma Jää Brings herding calls and mocking songs to Met Opera’s production of 'Innocence'

Vilma Jää never expected to play a major role in one of the 21st century’s most acclaimed operas when she enrolled at the Sibelius Academy to study folk music | KCBS All News 106.9FM and 740AM

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Apr 9 • 1:21 AM EDT • Entertainment • audacy.com
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Cavs withstand Hawks comeback in 122-116 win

The Cavs win a wild back-and-forth game for their 51st win of the year.

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Apr 8 • 10:14 PM EDT • Sports • sports.yahoo.com
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N.Y. Assembly Majority Leader Crystal Peoples-Stokes won't run for reelection

She has been in the Assembly since 2003 and currently represents the 141st Assembly District.

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Apr 8 • 2:19 PM EDT • Politics • spectrumlocalnews.com
Overwatch’s Next Hero Isn’t Who Fans Thought She Was

The game’s 51st hero looked a lot like a character from the novels

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Apr 8 • 12:33 PM EDT • Technology • kotaku.com
Why the U.S. Navy’s retail business is fighting Walmart and Amazon to fund its own future

The Navy runs more than 300 stores globablly but its operations are at risk because retail giants like Walmart, Amazon and Target are taking market share.

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Apr 8 • 7:00 AM EDT • Business • cnbc.com
Sporting 0-1 Arsenal: Kai Havertz scores in stoppage time to clinch Champions League quarter-final first-leg win

Match report as Kai Havertzs 91st-minute goal clinches a 1-0 win for Arsenal in the first leg of their Champions League quarter-final against Sporting; David Raya made several vital saves; Gunners welcome Sporting to Emirates Stadium for second leg next week

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Apr 7 • 6:10 PM EDT • Sports • skysports.com
On the Schedule: The PRWeek Sports Conference

The PRWeek Sports Conference returns this month with a world champion keynote speaker in Breanna Stewart.

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Apr 7 • 11:14 AM EDT • Sports • prweek.com
The Pokemon Champions early download bonus has been enhanced

The Pokemon Company have revealed that those who download and play Pokemon Champions from 8th April through to 31st August will not only get a Dragonite but you will also get 100 Quick Coupons.

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Apr 7 • 6:58 AM EDT • Technology • mynintendonews.com
PREVIEW | Sporting Cristal vs Cerro Porteño - team news, lineups, predictions

Sporting Cristal and Cerro Porteño face each other this Thursday at the of the Copa Libertadores. Sporting Cristal mark their 41st participation in the competition, whilst Cerro Porteño go into the...

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Apr 6 • 10:05 PM EDT • Sports • sports.yahoo.com
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VML Health urges marketers to shift from lifespan to ‘joyspan’ as patient goals evolve

VML Health has

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Apr 6 • 9:12 AM EDT • Health • fiercepharma.com
UCLA beats South Carolina for 1st NCAA women's basketball title

Gabriela Jaquez and UCLA handily defeated South Carolina for its first women's basketball national championship under the governance of NCAA.

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Apr 5 • 6:10 PM EDT • Sports • arizonasports.com
Ringling Bros. Barnum & Bailey makes grand return to CT visiting two arenas with brand-new acts

The legendary circus continues its 21st century makeover featuring 65 performers, from aerialists to acrobats to trick cyclists to people who dive through hoops.

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Apr 5 • 5:00 AM EDT • Entertainment • courant.com
No experience needed? Novices, newcomers dominate field in SC’s open coastal seat in US Congress.

SC’s 1st Congressional District race is packed with outsiders — just five candidates have ever held elected office. Mark Sanford’s surprise entry is reshaping an already crowded primary and making the path tougher for lesser-known hopefuls.

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Apr 5 • 5:00 AM EDT • Politics • postandcourier.com
White Sox's Munetaka Murakami hits 4th HR in 1st 8 MLB games, besting Shohei Ohtani's record by Japanese player
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Apr 4 • 6:01 PM EDT • Sports • sports.yahoo.com
Downtown Lancaster celebrates 1st First Friday of spring [photos]

Those in downtown Lancaster were able to celebrate spring's first First Friday event for 2026 this Friday. There were plenty of new exhibitions to check out, as well as concerts

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Apr 3 • 7:30 PM EDT • Entertainment • lancasteronline.com
Injury strikes Tobias Harris but Daniss Jenkins delivers for Pistons

Detroit Pistons score: Tobias Harris left in the 1st half with a knee injury, but Jalen Duren had a double-double in the Pistons' win over Minnesota.

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Apr 2 • 10:00 PM EDT • Sports • sports.yahoo.com
San Diego's 1st women's sports bar opening in North Park

One of Us opens in North Park, giving fans a dedicated space to watch women's sports.

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Apr 2 • 6:08 PM EDT • Sports • axios.com
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Wilson Building Bulletin: Pepco and politics

Also: The fight over the youth curfew in D.C. intensifies, and the council overrides Bowser.

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Apr 2 • 1:48 PM EDT • Politics • 51st.news
Artists' Cooperative to host 31st annual 'Regional Art Exhibit'

WESTERLY — Peter Geisser, former art director at the Rhode Island School for the Deaf, is serving as guest juror for The Artists’ Cooperative Gallery of Westerly's annual "Regional Art

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Apr 1 • 8:40 PM EDT • Entertainment • thewesterlysun.com
Commute: Diamond sports see different fates on Tuesday

The morning commute for Wednesday, April 1st, 2026.

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Apr 1 • 6:00 AM EDT • Sports • sports.yahoo.com
Munson’s Chocolates Selected for TD Small Business Takeover at TD Garden During March 31st Bruins Game

Eight Decades of Handcrafted Chocolate Meets One of Boston’s Biggest Stages

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Mar 31 • 10:36 AM EDT • Business • nhl.com
Here's Another Major PS5, PS4 Game Getting Delisted Soon

Rec Room goes offline on 1st June

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Mar 31 • 6:00 AM EDT • Technology • pushsquare.com
GTA 6 Could Cost $3 Billion, Making It the Most Expensive Entertainment Project Ever

GTA 6's development costs could exceed $3 billion, potentially making it the most expensive entertainment project ever.

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Mar 30 • 12:01 PM EDT • Entertainment • mp1st.com
Mark Sanford files to run for his old congressional seat by sounding alarm on national debt

Former U.S. Rep. Mark Sanford has filed to run for his old seat in South Carolina’s 1st Congressional District, returning to politics to press his long-standing focus on the national debt and deficit.

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Mar 30 • 6:25 AM EDT • Politics • postandcourier.com
Mets’ Sean Manaea prioritizing health over velocity concerns in wait for 1st 2026 outing

QUEENS, NY — Sean Manaea is still waiting for his first opportunity to get into a game out of the bullpen this season, but remains adamant that his lagging

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Mar 29 • 12:03 PM EDT • Health • amny.com
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Borderlands 4 Faces Backlash Over $30 DLC That You Can Finish in Two Hours

Borderlands 4 DLC faces criticism as players claim the $30 expansion lasts barely two hours, questioning its price and content

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Mar 28 • 10:48 AM EDT • Technology • mp1st.com
Arizona softball run-rules Baylor in 1st matchup since 2017

It didn’t make up for 2017, but it didn’t hurt, either.

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Mar 28 • 1:48 AM EDT • Sports • sports.yahoo.com
Commute: The churn of the carousel

The Morning Commute for Friday, March 21st, 2026.

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Mar 27 • 6:00 AM EDT • Sports • sports.yahoo.com
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Dollywood adds another race weekend for runners. When, how to sign up

Dolly Parton's theme park will host a second race weekend later this year after the inaugural spring event nearly sells out.

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Mar 27 • 5:02 AM EDT • Entertainment • knoxnews.com
PlayStation Store Spring Sale Brings the Best Promotion of the Year So Far

The PlayStation Spring sale is live and brings over 5,400 items to the discount rack and includes a slew of new AAA games.

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Mar 25 • 7:50 PM EDT • Technology • mp1st.com
Leon Radvinsky, 43, Dies; Built the Adult-Entertainment Giant OnlyFans

By leveraging social media and the influencer economy, he turned his website into a byword for online pornography in the 21st century.

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Mar 25 • 6:28 PM EDT • Entertainment • nytimes.com
Business Insider wins two SABEW awards

Business Insider won the categories of International Reporting and Video at SABEW's 31st annual Best in Business awards.

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Mar 25 • 3:28 PM EDT • Business • businessinsider.com
Birthday boy is Bach!

Blue Hill Bach will celebrate Early Music Month with an “intimate chamber baroque” concert honoring Johann Sebastian Bach’s 341st birthday at St. Francis by the Sea Episcopal Church on Friday,

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Mar 25 • 8:00 AM EDT • Entertainment • ellsworthamerican.com
Divided Supreme Court weighs the right to seek asylum at the southern border

The case posed a fundamental clash between the government's need to manage surges at the border and the moral and historic right to offer asylum to those fleeing persecution.

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Mar 24 • 3:38 PM EDT • Politics • latimes.com
Modernizing Pinnacol is about its members, not politics

By Akasha Absher While we share the passion for protecting Colorado’s workers expressed in a recent op-ed from the perspective of trial attorneys and union representatives, the piece paints a picture of Pinnacol Assurance that is more rooted in 1915 than our 21st-century reality (“Colorado’s workers can’t afford a privatized Pinnacol | OPINION,” March 17). […]

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Mar 24 • 2:45 AM EDT • Politics • coloradopolitics.com
Astrophysicist Deborah Haarsma Connects Science with Christian Faith at Pepperdine Libraries' Frank Pack Lecture

Hosted by Pepperdine Libraries' Rushford Center, the University community was given the special honor of hearing Haarsma's insights on Christian faith and science at the 21st annual Frank Pack Distinguished Christian Scholar Lecture.

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Mar 23 • 7:34 PM EDT • Science • pepperdine.edu
Your Thymus and Your Healthspan

Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.

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Mar 22 • 2:18 PM EDT • Health • erictopol.substack.com
Game Preview: Carolina Hurricanes @ Pittsburgh Penguins 3/22/2026

Who: Carolina Hurricanes (44-19-6, 94 points, 1st place Metropolitan Division) @ Pittsburgh Penguins (35-18-16, 86 points, 2nd place Metropolitan Division) When: 3:00 p.m. eastern How to Watch: Locally broadcast on Sportsnet Pittsburgh and FDSN South, streaming on ESPN+ Pens’ Path Ahead: Quality opponents await in the next week; the Pens host Colorado on Tuesday, an Avs team […]

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Mar 22 • 6:00 AM EDT • Sports • sports.yahoo.com
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Report: PlayStation's Firesprite Studio Almost Made Breaking Bad VR, as Well as a New Sci-Fi Horror Game

From a canceled Breaking Bad VR experience to a secret sci-fi horror title, we delve into two shelved projects of PlayStation’s Firesprite.

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Mar 21 • 3:54 PM EDT • Technology • mp1st.com
Young scientists shine at Regional Science Olympiad

Budding young scientists from throughout the region participated in the 41st Annual Stanislaus County Regional Science Olympiad on March 14 at Modesto Junior College.

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Mar 21 • 2:20 PM EDT • Science • turlockjournal.com
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Apple TV Is Now Almost 20 Years Old

The Apple TV is now almost two decades old amid rumors of the announcement of a new model. Today marks 19 years Apple launched the original Apple TV. Apple CEO Steve Jobs unveiled the Apple TV at Macworld Expo in January 2007 alongside the original iPhone, but it didn't launch until March. The ‌Apple TV was initially previewed as the "iTV". The device allowed users to wirelessly stream movies, TV shows, music, and photos from their Mac or PC directly to their TV.

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Mar 21 • 9:14 AM EDT • Technology • macrumors.com
No. 11 VCU storms back from 19 down to stun No. 6 North Carolina with largest 1st-round comeback in NCAA tournament history

Terrence Hill Jr. powered the comeback with 34 points including 23 after halftime while shooting 7 of 10 from 3.

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Mar 19 • 10:15 PM EDT • Sports • sports.yahoo.com
Michigan declares 1st measles outbreak as cases spread 'like wildfire'

All three measles cases reported in March in Michigan are linked to a person in Washtenaw County who likely contracted it on a trip to Florida.

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Mar 19 • 5:28 PM EDT • Health • freep.com
Albatross Entertainment takes top spot as Best New Tenpin Center in the U.S.

EDISON, N.J. — Albatross Entertainment (Albatross) in Edison, New Jersey, has been named Best New Tenpin Center in the U.S. in the 41st Annual Bowling Center Architecture and Design Awards, present…

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Mar 18 • 10:03 AM EDT • Entertainment • amusementtoday.com
Why You Should Stop Worrying About AI Taking Data Science Jobs

It's all just fearmongering

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Mar 18 • 9:30 AM EDT • Science • towardsdatascience.com
Dick Van Dyke Credits His Longevity to One Habit, And Science Supports It

He turned 100 last year.

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Mar 17 • 7:15 PM EDT • Science • sciencealert.com
Report: The Wolf Among Us Current-Gen Port Is in the Works

New evidence suggests a remaster or port of the original The Wolf Among Us could be in development, as we tie it to a recent report.

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Mar 15 • 4:19 PM EDT • Technology • mp1st.com
West Virginia repeats, wins program's 21st NCAA rifle title

West Virginia defended its NCAA rifle championship on Saturday, edging out TCU to claim the 21st national rifle title in program history.

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Mar 14 • 7:07 PM EDT • Sports • espn.com
Big Ten basketball tournament live updates, scores, bracket: Michigan vs. Wisconsin
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Mar 14 • 12:12 PM EDT • Sports • sports.yahoo.com
Contributor: Federal power grabs on elections are not about fraud

Trump has called the SAVE Act his top priority. But why? His commission found no widespread problem that needed solving.

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Mar 14 • 6:00 AM EDT • Politics • latimes.com
‘Access Hollywood’ canceled as NBCUniversal ends 1st-run syndication

After nearly three decades, NBC Universal is pulling the plug on the entertainment magazine show “Access Hollywood.” The move comes as the media giant announced it will stop producing f…

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Mar 13 • 4:34 PM EDT • Entertainment • ktla.com
Big Ten basketball tournament live updates, scores, bracket: Michigan vs. Ohio State
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Mar 13 • 11:59 AM EDT • Sports • sports.yahoo.com
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Big Ten basketball tournament live updates, scores, bracket, how to watch
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Mar 13 • 10:01 AM EDT • Sports • sports.yahoo.com
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Former Yankee Mark Teixeira says baseball prepared him for career in politics

Teixeira recently won the Republican primary for Texas' 21st Congressional district.

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Mar 13 • 5:00 AM EDT • Politics • newsday.com
Big Ten basketball tournament scores, results: Wisconsin, Ohio State, Purdue, UCLA advance
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Mar 12 • 11:08 PM EDT • Sports • sports.yahoo.com
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Oregon Health Authority identifies Gresham grocery store as latest measles exposure site

People who visited Gresham’s WinCo Foods, located on 2511 SE 1st St., on Saturday, March 7 between 2 p.m. and 5 p.m. may have been exposed to measles.

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Mar 12 • 10:24 PM EDT • Health • opb.org
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Big Ten basketball tournament live updates, scores, results: Wisconsin, Ohio State, Purdue advance
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Mar 12 • 8:45 PM EDT • Sports • sports.yahoo.com
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New dining, entertainment venue set to open near Westfield's Grand Park

A new entertainment and dining destination is opening near Grand Park in Westfield. The Westfield Collective is set to open this month on four acres at Grand Park Boulevard and East 181st Street. In...

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Mar 12 • 7:54 PM EDT • Entertainment • yahoo.com
Business News: TAG Heuer Names Béatrice Goasglas, Current Head Of The Americas, As New CEO

In a bid for executive stability, TAG says Goasglas, who has been with the brand since 2018, will take over the top job May 1st.

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Mar 12 • 2:55 PM EDT • Business • hodinkee.com
State College Student Wins 1st Place, and a $250K Prize, in National Math and Science Competition

A State College Area School District student won first place on Tuesday night in a national math and science competition for high school seniors billed as

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Mar 11 • 4:39 PM EDT • Science • statecollege.com
Michigan reports 1st measles case of 2026: What you need to know

Health officials say an adult with measles exposed others to the virus between March 4-8 at multiple locations across two Michigan counties.

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Mar 11 • 1:19 PM EDT • Health • freep.com
Acuff Named 1st Team All-America by The Sporting News

Arkansas freshman Darius Acuff was selected first team All-America by The Sporting News, it was announced today.

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Mar 11 • 11:23 AM EDT • Sports • arkansasrazorbacks.com
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‘A nightmare;’ Business owner speaks out after city shuts down building that houses salon

City inspectors closed the E 1st Street parking garage several weeks ago due to structural concerns.

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Mar 10 • 5:34 PM EDT • Business • yahoo.com
Yoshi and the Mysterious Book is coming to the Switch 2 later this Spring, features bubble-blowing freaky fellas you can eat

Nintendo has released a gameplay trailer for Yoshi and the Mysterious Book, with the game launching on the 21st May.

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Mar 10 • 11:45 AM EDT • Technology • eurogamer.net
Bruce Pearl celebrates Miami RedHawks' undefeated regular season

College hoops analyst Bruce Pearl, who had suggested the RedHawks' weren't worthy of an at-large bid, celebrated Miami's 31st win with a tweet.

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Mar 7 • 2:30 AM EST • Sports • sports.yahoo.com
Bandcamp Friday is here again.

The next one won’t be until May 1st, so if you’ve been itching to pick anything up, maybe today is the day. Let me know what you’re grabbing in the comments. I’m eyeing a few things, including the collab between Montreal rapper cropscropscrops and NYC producer Vaygrnt: We’ve Been After Each Other. [Media: https://cropscropscrops.bandcamp.com/album/weve-been-after-each-other]

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Mar 6 • 9:24 AM EST • Entertainment • theverge.com
Reps. Finstad, Craig spar over farm bill politics in marathon House Agriculture committee

Rep. Brad Finstad, R-1st, accused Rep. Angie Craig, D-2nd, of playing politics with farm policy because she is seeking higher office.

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Mar 6 • 5:59 AM EST • Politics • minnpost.com
Yanis Varoufakis on Donald Trump, global conflicts and the AI revolution

The economist, author and former politician Yanis Varoufakis speaks to political editor Tom McIlroy about his blunt assessment about the ability of the global economic system to address the biggest challenges of the 21st century

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Mar 5 • 9:11 PM EST • Politics • theguardian.com
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NC-11 race could depend on independent votes, national politics: former NC Rep. Shuler

The last Democrat to hold the seat of NC-11 says the outcome of November's general election could hinge on independent voters and national political winds.

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Mar 4 • 5:13 PM EST • Politics • wlos.com
Retired Yankee Mark Teixeira wins Texas GOP primary as sports figures chase politics

Teixeira took more than 61 percent of the vote in Texas’ 21st Congressional district to win the 12-candidate field.

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Mar 4 • 4:28 PM EST • Politics • nytimes.com
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Retired Yankee Mark Teixeira wins Texas GOP primary as sports figures chase politics

Teixeira took more than 61 percent of the vote in Texas’ 21st Congressional district to win the 12-candidate field.

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Mar 4 • 4:28 PM EST • Sports • nytimes.com
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Business briefs: Yeo & Yeo honored; Dow CU hits 1K customers

Yeo & Yeo is proud to announce that Andrew Matuzak, CPA, PFS, principal and director of Yeo & Yeo Wealth Management, has been honored as one of eight recipients of the 21st Annual RUBY...

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Mar 1 • 11:07 PM EST • Business • ourmidland.com
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TST Images: UCLA defeats USC, 73-50, at Galen Center

LOS ANGELES, Calif - The UCLA Bruins Women's Basketball team defeated the USC Trojans, 73-50, at Galen Center on March 1st, 2026 and The Sporting Tribune's Paige Creason was there to capture the following TST Images.

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Mar 1 • 8:31 PM EST • Sports • sports.yahoo.com
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Guardians News and Notes: Espino Starts Today

News and Notes for Sunday, March 1st, 2026

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Mar 1 • 8:26 AM EST • Sports • sports.yahoo.com
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Golden Nuggets: The 49ers march toward a new season

Your daily San Francisco 49ers news for Sunday, March 1st, 2026

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Mar 1 • 5:02 AM EST • Sports • sports.yahoo.com
Video Game Archive Myrient To Shut Down On March 31

Recently the Myrient game video archive announced that they’re shutting down on March 31st of this year, for a couple of reasons, but primarily the skyrocketing financial costs of hosting the…

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Feb 27 • 4:00 PM EST • Technology • hackaday.com
Denver Broncos to start offseason program later than usual

A minor bit of offseason schedule news this week with head coach Sean Payton telling Pat McAfee on his show that Phase 1 of the Denver Broncos offseason program won’t start until around May 1st. Typically, that first start date happens in mid-April so it’ll be a few weeks later than what we’ve seen in […]

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Feb 27 • 6:00 AM EST • Sports • sports.yahoo.com
Arts and entertainment events happening February 26th-March 1st across the Mid-Ohio Valley

Joe Oliverio joins Daybreak to discuss what’s happening February 26th-March 1st across the Mid-Ohio Valley!

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Feb 26 • 7:58 AM EST • Entertainment • wtap.com
Sofia Vergara on How Her Mom Inspired Her Heart Health Mission

Sofia Vergara joins TODAY to talk about “America’s Got Talent” as it begins its 21st season, appearing in three Super Bowl commercials during one game, and how her mom’s experience with high blood pressure inspired her heart health mission to spread awareness about uACR tests that detect early kidney damage. (Sponsored by Boehringer Ingelheim)

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Feb 24 • 11:04 AM EST • Health • today.com
Honored by the National Arts & Entertainment Journalism Awards: First Place for Podcast Host

I’m deeply honored to share that my podcast, Make Your Own Map, was recognized by the National Arts & Entertainment Journalism Awards (NAEJ) with

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Feb 24 • 11:00 AM EST • Entertainment • jewishjournal.com
2026 NFL mock draft: Broncos make surprising 1st-round pick

The Broncos begin planning for the future in this 2026 NFL mock draft.

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Feb 24 • 9:01 AM EST • Sports • sports.yahoo.com
Tulsa Women's Expo celebrates 41 years of supporting business owners and creators

Now in its 41st year, the long-running show continues to spotlight female entrepreneurs, artists, authors and chefs from across the community. The event runs from 11 a.m. to 4 p.m.

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Feb 22 • 11:30 AM EST • Business • newson6.com