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Doctors Say This Cooking Mistake Could Be Harming Your Health
Doctors share how oversalting your food could increase your risk for heart disease, plus ways to cut back while still enjoying flavorful meals at home.
Mikel Arteta interview: Arsenal manager urges his players to enjoy final weeks of the season with Premier League and Champions League title races
Theater companies offer Shakespeare, Elvis, Broadway, burlesque in May
Before Memorial Day ushers in the summer season, theater companies around Lancaster County are offering a variety of plays, musicals and cabarets for all ages to enjoy this month.
April Social Media Round-Up—Trailblazer Cancer Research Grants, World Health Day, and More
April has come to a close and we are barreling towards the summer. Before you head outside to enjoy spring, take a moment to catch up with Pfizer’s social channels, which have been on fire. Check out updates across our channels.
Fine chandeliers are a specialty for New Orleans business | Home/Garden
Michael Melesurgo and Ricardo “Rico” Mencia purchased Classic Chandelier from the business’s founder, Peter Sather, in 2023, when he decided to retire. The business partners rebranded the company as Vintage Chandelier and relocated it to 455 Philip St. in the Irish Channel in December 2025.The company offers a variety of services including cleaning, moving, restoration, installation, pick-up, delivery and general maintenance of light fixtures, with a specialty in fine antique chandeliers.Additional specialties include the installation and restoration of mirrors and artwork, with pick-up and delivery included. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-1'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-1'); }); “We mainly focus on older fixtures, but we have also worked on newer ones, especially with installation,” Melesurgo said. “We aim to be able to work on almost anything within reason. But chandeliers are the meat and potatoes of the business.” googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-1'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-1'); }); The team at Vintage Chandelier has worked on some of the best-known chandeliers in New Orleans, at hotels including the Ritz-Carlton and the Hyatt Regency, the Milton H. Latter Memorial branch of the New Orleans Public Library and several prominent homes.Inside Out sat down with the duo to discuss the identification and care of fine chandeliers. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-2'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-2'); }); What are some of the hallmarks of a fine chandelier?Melesurgo: Some of the finer points of elegant chandeliers are pristine crystal, clean craftsmanship, original pieces and parts and stamped pieces to ensure authenticity. Everything should be clean and working.How should you clean a fine chandelier?Melesurgo: The material in question determines the methodology for cleaning. Crystal chandeliers should be cleaned by hand, crystal by crystal, to ensure the best outcome, and to avoid deterioration of metal wiring typically used in connecting pieces together. Spraying cleaners can, over time, sit on the metal and end up rusting connections that compromise the connections. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-3'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-3'); }); googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-2'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-2'); }); What in your backgrounds led you to this business?Melesurgo: I have an electrical background. I started as an electrical apprentice in the local union (IBEW 130) in 2005. Then Katrina hit. I ended up going back to school and getting a degree in Hotel, Restaurant and Tourism and graduating in 2011. I started working for Peter (Sather) at Classic Chandelier & Mirror in 2012, which was supposed to only be temporary, but I ended up staying for a lot longer. I have always enjoyed working with my hands and being creative. This allows me to be creative and keep a lot of beautiful history alive. googletag.cmd.push(function() { googletag.display('fixed-breakout-mobile-4'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-tablet-4'); }); Rico, you worked as a draftsman alongside an engineer at YKM Consulting. googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-3'); }); googletag.cmd.push(function() { googletag.display('fixed-breakout-desktop-3'); }); Mencia: The job was interesting, especially working on the Ochsner expansion, but staring at two monitors all day became unbearable. I went to work for Peter (Sather), which opened a new world to antiques and chandeliers that I find fascinating. Vintage Chandelier, 455 Philip St., (504) 309-8983, @vintagechandelier.504 on Instagram googletag.cmd.push(function() { googletag.display('fixed-sticky-rail-4'); });
Matt Law names three “confirmed” candidates for Chelsea manager’s job
Matt Law named the three outstanding candidates for the Chelsea managerial role as things stand on a podcast.If you enjoy Chelsea News coverage and want to see more of it, add us as a preferred source...
Viewpoint: A career in science is possible, and worth it
Starting a career in science is exciting, but also demanding, with researchers often faced with intense competition, long working hours and high levels of stress. A pioneer in the field of mass spectrometry, Carol Robinson has been there. She speaks with Science|Business on the importance of creating a supportive environment, particularly for women.Robinson did not wake up one day thinking that she would become a scientist. It was only late in school that she developed an interest in chemistry. “The more you work at something, the more you think, actually, this is fascinating. So, I went much further and deeper than I ever needed to pass the exam. And then I loved it,” she says. “I thought, I’m going to give it my all. I’m going to enjoy it while I’m here. But I didn’t think this would be my career for 50 odd years.”She left school at 16 to become a lab technician with the drug company Pfizer, which is where she first worked with mass spectrometry. Fascinated, she was encouraged to take a part-time degree and then a PhD. She went on to do pioneering work in native mass spectrometry, a technique that is used to study protein structures in their natural state, paving the way for breakthroughs in drug discovery. She also broke new ground by becoming the first female professor of chemistry at the University of Cambridge, and then the first female professor of chemistry at the University of Oxford, her current home.She now wants to show young researchers that a career in science is worth it. “Sometimes, I believe the culture isn’t very encouraging, and that’s something I have worked on,” Robinson says.In 2021, she launched the Kavli Institute for Nanoscience Discovery at Oxford, whose acronym gives a sense of what she hopes it will achieve. “Maybe it is corny,” she says. “It’s just a reminder that I would like it if we could all be kind to each other and supportive, especially for early-career researchers of either gender, because there’s quite a big attrition rate in science, and maybe it just doesn’t feel like a very friendly place to work.”And yet, a career in science comes with a lot of flexibility. “There are few careers where you have that amount of freedom, to go to conferences, to the library. Just because you didn’t see me didn’t mean I wasn’t working,” she says. “And I’m excited to come in every day. So, I don’t want people to think it’s a terrible place.”Gender equality is also important when it comes to the quality of science as a career. “The more women we have, the better it becomes,” Robinson adds.Imposter syndromeAccording to EU data, women outnumber men in university education but account for just about a third of graduates in science, technology, engineering and mathematics (Stem). And while the number of women working as scientists and engineers in the 27-member bloc is on the rise, their representation remains below that of men, at 41%. This discrepancy is even more pronounced in top-tier functions across these fields, where women fill just 20% of positions.Having supervised many young scientists, Robinson sees that women continue to have a greater propensity than men to doubt their abilities, a feeling she once shared. “When I was doing my PhD at the University at Cambridge, I really felt like an imposter,” she says. “I don’t think I ever felt I deserved to be there or owned it and was proud. I just thought I was lucky.” Later on, she adds, “I was always that person who said, I can’t apply yet because my CV is not strong enough.”She has now made it her job to encourage women to break with this imposter syndrome. For example, rather than calling for volunteers to give a lecture in the groups that she mentors or teaches, which nearly always results in men stepping forward, she goes straight to the women, “because I know they won’t push themselves forward.”But the gender gap in science is not just down to imposter syndrome. The “obvious” reason, Robinson says, and the reason that is on everybody’s mind when discussing workplace gender equality, is the balance between work and raising a family. Her own path was to choose between the two, taking an eight-year break after completing a postdoctoral training fellowship to bring up three children. And she continues to advise women not to work part-time while they raise a family. “You’ll just get half the pay and continue to work full-time because you are not able to fit everything in,” she says. “You should be able to have a family and come back to have the career that you want.”The solution is for men to also take career breaks. “That kind of evens it up, so that it’s not such a big thing for women,” Robinson says. “I always encourage men in my groups to do that. I think it’s important to take your share of the duties.”Support produces resultsAccording to the Women in Stem Network, a UK advocacy group, countries with strong childcare systems and equal pay policies retain more women in technical careers. In Europe, these are primarily found in the Nordic region and parts of central Europe.At the EU level, the European Commission asks all Horizon Europe applicant organisations to have a gender action plan in place. Since this criterion was introduced in 2021, the share of women leading consortia has increased to 31%, against 23% in Horizon 2020. Their overall participation, however, has risen just 1%, to 38%. After trying to weaken the requirement for gender action plans in 2025, the Commission now intends to adopt a plan for supporting women in research and innovation.Related articlesCommission scraps plan to water down gender requirements in HorizonHow gender balance can swing who wins Horizon Europe fundingRobinson herself has benefited from three Advanced Grants from the European Research Council. “I was extremely honoured and privileged to get those, because they really allowed me to fuel my passion,” she says. “Without that, it would have been a much harder slog.”Beyond applying gender rules, she says that more work is needed on translational enterprise, where women are, once again, largely underrepresented. The European Patent Office found that only 13.8% of applications were filed by women in 2022. “We have so many more women doing amazing science; why do they feel it’s not a thing to have a company?” she asks.She founded her own spin-out company, OMass Technologies, in 2016, and remains chair of its scientific advisory board now that it trades as OMass Therapeutics. As for research, Robinson is now studying how changes in the brain may be linked to depression, using port-mortem tissue. “We’re hoping to publish soon,” she says. “We had to consult with a lot of people who knew a lot more about the brain than we did. So, we’ve learnt a lot, and that’s always a lot of fun to learn a new thing. That’s what keeps you going.”
Who was invited to dinner with King Charles: Justices, business leaders and Palm Beach friends
President Donald Trump and first lady Melania Trump hosted a white-tie dinner at the White House with King Charles III and Queen Camilla. Nearly 130 guests enjoyed Dover sole meunière and a beehive-shaped chocolate dessert on Tuesday night. The guest list included business leaders, tech CEOs and friends from Palm Beach, Florida. The six conservative justices on the Supreme Court also attended, despite Trump’s recent criticism over tariffs. Fox News stars and other conservative media figures were present, along with three of Trump’s children, his father-in-law, sports figures and lawmakers, including House and Senate leaders.
Never miss the action: FOX One brings streaming sports and more to Delta Sync
SkyMiles® Members can now enjoy 24-hour complimentary access to the FOX One streaming platform — home to sports, news, weather, business, entertainment and more — through Delta Sync Wi-Fi. The new partnership brings more than 5,000 hours of live programming on board and positions Delta Sync as a premium destination for major sports moments.
A.I. Helps Online Ad Businesses Boom
Google and Meta are enjoying a digital ad boom, as artificial intelligence automates marketing and drives record sales.
See where Kansas baseball ranks in USA TODAY Sports Coaches Poll
KU baseball enjoyed a rivalry sweep over the weekend against Kansas State. So, where does it rank in the top 25 of the USA TODAY Sports Coaches Poll?
Bounce into Summer with Party Hats Entertainment!
Evan leads Abby, Rachel, Cesar and Maurissa in an obstacle course and nerf gun fight to be enjoyed by kids and adults alike.
Jim Krukal Wants Clevelanders to Sink Their Worries on His Interactive Cuyahoga Cruise Line
Join Jim Krukal for the Sink Your Worry Cleveland sunset cruise. Enjoy drinks, quests, and fun on the Cuyahoga River.
The Autograph Wedding Experience hosts expo at Hotel Paso del Norte
EL PASO, Texas (KVIA) -- The Autograph Wedding Experience held a wedding expo Sunday evening at Hotel Paso del Norte. The event featured fully designed wedding environments, giving attendees a chance to explore different styles and themes for their big day. Guests also enjoyed a runway show highlighting the latest in bridal fashion. In addition
Canada's Carney has enjoyed a long political honeymoon. Now comes the test
Global acclaim and domestic political gains have defined Mark Carney's first year as Canada's PM. He now faces pressure to deliver on his bold promises.
Iraq’s Communists Are Fighting Against Sectarian Politics
Although Iraq’s Communist Party has lost much of the support it enjoyed at its peak, it still has a real presence on the Iraqi political scene. Its general secretary Ra’id Fahmi tells Jacobin about the need to challenge Iraq’s sectarian power structure.
"We want players to spend their time actually enjoying the content they're passionate about" – Honkai: Star Rail Developers Discuss the Future, Potential Switch 2 Port, Himeko’s Coffee, and More
Ahead of its third anniversary, we spoke to the Honkai: Star Rail development team to discuss plans for the future, a potential Trails collaboration, Steam Deck and Switch 2 support, Himeko's coffee, and much more.
BR Symphony to perform during planetarium show at La. Art and Science Museum
An upcoming event will give people the chance to hear the sounds of the Baton Rouge Symphony while also enjoying a planetarium show.
"The Cars That Made Us" Works as Education and Entertainment
Comic Jeff Dunham's "The Cars That Made Us" is a fun, entirely enjoyable portrait of a compelling car, one per episode.
The One Gala is a record-breaking $1 million success
COLORADO BALLET Denver News: In the 20 years that Gil Boggs has been the artistic director of Colorado Ballet, the company has been on an upward trajectory; its stature rising from mixed local reviews to the national acclaim it now enjoys. Boggs’ tenure was celebrated at the company’s April 16 fundraiser, The One Gala, a black-tie fete where the 655 guests raised a record $1 million. Chairwoman Jill Anschutz and mistress of ceremonies Lauren Whitney were just […]
CBL Scholars Program Opens Pathways to Business Law Careers - UC Law San Francisco (Formerly UC Hastings)
First-year law students and 2026 CBL Scholars Deniz Masjedi, Alvaro Flores, and Tavia Pappaly gain mentorship connections with leading industry professionals as they prepare for careers in business law. Created by the UC Center for Business Law San Francisco (CBL), the CBL Scholars Program aims to develop the next generation of business law leaders, supported by contributions from individuals and corporate sponsors. The highly competitive program provides funding along with academic and professional mentorship to students from disadvantaged backgrounds. Scholars gain exposure to the Bay Area’s technology and venture capital ecosystems and access to UC Law SF’s broad network of senior legal professionals. Now in its sixth year, the CBL Scholars Program provides a scholarship and academic and professional mentorship to students entering the business law community from disadvantaged educational, economic, social, or physical backgrounds. The program is generously sponsored by the law firms Gunderson Dettmer and Goodwin Procter. Meet this year’s CBL Scholars: Deniz Masjedi, Alvaro Flores, and Tavia Pappaly. All three have secured summer associate positions at prestigious law firms. Deniz Masjedi: A Passion for Helping Founders Grow Companies Deniz Masjedi, who was born in Iran and moved to Southern California as a teenager, traces her interest in law to her family’s immigration journey and her desire to advocate for herself and her family. She earned a bachelor’s degree at UC Berkeley, where she studied political science and sociology. At UC Law SF, she serves as a 1L representative for the Iranian Law Students Association and is active in the Business Law Society and Technology & Law Society. Next fall, she will serve as director of mentorship for the Technology & Law Society and director of professional development for the Business Law Society. She will join Sidley Austin this year as a 1L/2L summer associate. Q: What draws you to business law? A: Prior to law school, I worked in Cooley LLP’s Private Companies practice group as a corporate paralegal for three years, supporting over 100 venture-backed startups and venture capital funds. I found purpose in helping founders transform their vision into successful companies. It was incredibly rewarding being part of their journeys—from company formation and initial financing to major transactions such as M&A deals. What excites me most about this field is the potential for a small, innovative company to become the next Google or Zoom, shaping how people communicate and access information. I hope to continue supporting entrepreneurs and investors as a corporate attorney. Q: What does it mean to you to have been awarded this scholarship? A: As the first person in my family to attend law school in the United States, receiving this scholarship is a tremendous honor. My parents and I left everything behind so that I could enjoy the freedom to practice my religion without persecution and pursue a career in law as a woman. This award is an acknowledgment of my dedication to business law and motivates me to continue pursuing excellence in this field. It also recognizes years of hard work—learning a new language, navigating the college and law school application process, and ultimately building a career in the legal profession. Q: How will this scholarship help support your future goals? A: This scholarship will provide access to mentorship from leaders in the field, enabling me to develop the skills necessary to offer practical advice and effective representation to future clients. It also eases the financial burden of law school, letting me focus on my coursework and deepen my commitment to corporate law. As an immigrant, breaking into the legal profession has not always been easy, and the time that mentors have invested in me has been instrumental to my progress. This scholarship will allow me to continue building those relationships while positioning me to one day mentor others pursuing similar paths. Alvaro Flores: Inspired by Entrepreneurs The son of Mexican immigrants raised in San Antonio, Texas, Alvaro Flores says he has long been interested in how policy, markets, and culture shape society. He studied international relations and global economy at the University of Southern California, with minors in business finance and legal studies. His experiences span local political organizing, venture capital and startup work, and teaching entrepreneurship. At UC Law SF, he is involved in the Business Law Society, Technology & Law Society, and the Latinx Law Student Association. He will join Perkins Coie as a 1L/2L summer associate with the firm’s Emerging Companies & Venture Capital practice. Q: What draws you to business law? A: I’m drawn to stories of entrepreneurs whose simple ideas become companies that shape the economy and society. Spending time in venture capital and working directly with founders has shown me that many important decisions in the scaling process are ultimately legal ones, particularly how companies are structured and how capital is raised. Business law sits at the intersection of innovation and equity. It offers a way to stay close to the pace of technological change while also helping expand who gets to participate in it. There is something special about being part of that process here in the Bay Area, where the American Dream feels like it is reimagined in real time. Q: What does it mean to you to have been awarded this scholarship? A: I am truly grateful for the support and belief this scholarship represents. I see it not just as recognition, but also as alignment. The CBL Scholars Program’s focus on developing individuals who engage deeply with the business and technology ecosystem reflects the path I have been intentionally building. More than anything, it feels like an investment in that journey. I have been thoughtful about each next step–whether teaching, working in venture capital, or building multidisciplinary experiences–and this scholarship reinforces that those efforts come together in a meaningful way. Q: How will this scholarship help support your future goals? A: It allows me to focus more on developing as a business lawyer, without the distraction of financial constraints. Beyond that, the mentorship and access to the Bay Area network are just as valuable. I’m especially interested in working with early-stage companies and investors, so the opportunity to learn directly from people operating at a high level in that space is huge. Tavia Pappaly: Working in the Wine Industry Sparked Interest in Business and Law Tavia Pappaly spent five years in the wine industry before deciding to pursue law school with a goal of becoming a corporate transactions attorney. Pappaly says she wants to use her legal skills to help business grow and thrive. A first-generation law student from Fairfield, California, she is a member of the Legal Education Opportunity Program (LEOP) and will serve as vice president of social planning for the UC Law SF Sports Law Society in her 2L year. She plans to work as a summer associate at Gibson Dunn in San Francisco after her 2L year. Q: What draws you to business law? A: Business law brings together many of my interests and personal experiences. As the daughter of immigrants who grew up around a family-owned small business, I saw firsthand both the opportunities and challenges of building something from the ground up. That perspective, combined with my experience in the wine industry, solidified my interest in helping businesses of all sizes tackle evolving legal challenges. I’m excited to grow within the corporate law space and develop the skills and experience to support businesses at every stage. I’m deeply motivated to give back to immigrant communities and small business owners, whose experiences often intersect. By building a strong foundation in corporate law, I hope to support those working to create generational stability and to contribute in a meaningful way to the communities that have shaped me. Q: What does it mean to you to have been awarded this scholarship? A: Receiving this scholarship is incredibly meaningful to me. I take great pride in my background as a first-generation student and a woman of color, so being recognized for my potential in a field that has historically underrepresented those communities is both affirming and empowering. This program will help connect me to the resources and committed mentors that will help me succeed. Beyond that, it is no secret that law school is a significant financial commitment. This scholarship helps ease both the financial burden and the stress that comes with it, allowing me to focus more on my education and long-term goals. I am incredibly grateful! Q: How will this scholarship help support your future goals? A: This scholarship has already connected me with an incredible network of faculty, business law professionals, and like-minded students. The community fostered by the Center for Business Law is deeply supportive, and I’m excited to grow alongside my cohort. I truly believe this network will play an important role in helping me thrive in law school and position me for success in business law. As I have seen firsthand how impactful both financial scholarship and mentorship are, I hope to give back in this same way later in my career.
High Runner’s High: Marijuana and running in joint use across North Ashland
Running and cannabis use have several similarities. They both challenge a person’s lung capacity, they both generally result in an increased appetite, and they can both be enjoyed indoors or outside. Despite the overlap, the idea to participate in both simultaneously as a community is a relatively new concept. Chicago natives Anakaren Ramirez and Carlos...
Boosting the berry business
Blueberry growers recover from the blues and strawberries have their saviors after a blistery—by Florida standards—winter. Add other growing challenges and Southwest Florida’s berry businesses need a boost. Still, it’s peak season for blueberries in the area and residents can enjoy the healthy treat as the crop losses mostly affect commercial buyers, local growers said.
‘Sport as a Public Good’ talk spotlights gaps in youth sports education, access
There’s little that people enjoy more than play. Unfortunately, when it comes to our youth, we often fail in nurturing that love, former President of the U.S. Tennis Association and Chief Medical Officer of the NCAA Brian Hainline said. On Wednesday, April 15, Hainline spoke at the University of New Mexico Physics and Astronomy Interdisciplinary Science Building and said sports should be a public good to an audience including local sport leaders and athletes. He highlighted what he called an inadequate systemic support for sports in the U.S. Hainline’s lecture was hosted jointly by the UNM School of Medicine and Alumni Association.
STEM SHOWCASE AT YSU: Science concepts spawn real-world creations
YOUNGSTOWN — During her childhood, Meghan Crump enjoyed certain fast movements, though years later, her interest shifted to things that move quickly but are far smaller than her. “I was a very creative person in high school. I was a student who loved school,” Crump, a Youngstown State University senior and 2022 Austintown Fitch High […]
Dario's Randoms Round 2
Please enjoy a few unique bikes, some new kit, and a porta-potty based conspiracy.
Ubisoft’s New Action RPG Is Devil May Cry Meets Cyberpunk
Despite a string of recent controversies, a huge overhaul of its business model, and a restructuring of its most important IP, Ubisoft is seemingly continuing to produce good games. Sure, Assassin’s Creed Shadows was a fairly enjoyable revamp of a very familiar formula, and Star Wars Outlaws, as lambasted as it was at launch, impressed […]
Prom 2026 photos. Rankin County special education students dance the night away
RCSD special education students enjoyed prom at Florence High School in Florence, MS, during Prom 2026.
Virginia Beach Oceanfront curfew raises concerns for local businesses
Visitors and locals alike enjoyed a picturesque morning at the Virginia Beach Oceanfront, hours before the temporary emergency curfew takes effect.
5 mistakes to avoid on your first long-distance Amtrak ride
I took the 20-hour Amtrak route between Chicago and New York. These five mistakes kept me from enjoying it more.
Kid investors are making money from the Pokémon card trading boom
Pokémon has enjoyed a resurgence in recent years, becoming the world's No. 1 toy property, but it's a long way from the game many adults remember.
Why some tech leaders are sounding the alarm about Colorado’s ‘deteriorating’ business climate
Colorado enjoyed a reputation of being business-friendly in recent decades. But some in the business community worry that too much regulation is hurting the state’s ability to attract new companies. And they’re asking the governor for help.
New Stoner Survival Dealing 4X Rewards as LD Organics Presents: The 420 Event
The man with the van and the plan is putting his stamp on Los Santos this 420 as LD Organics Presents: The 420 Event. Celebrate with a new Hunting Pack (Get Lamar) location that’s dispensing 4X Rewards, enjoy a kaleidoscope of hallucinations along with...
UNC Hussman offers new sports play-by-play class | UNC Hussman School of Journalism and Media
This story, written by UNC Hussman alumna Caroline Daly ’24, was originally published on unc.edu. The UNC Hussman School of Journalism and Media has a new, hands-on class available for students interested in sports careers. Students in “MEJO 390: Sports Commentary and Play-By-Play” can call live radio broadcasts for Carolina sporting events, streamed live on the Go Heels website. This spring, 11 students are calling mostly softball games to gain experience and learn the preparation needed for a successful broadcast. The class is capped at a small number to provide consistent, individual feedback. Matt Krause, the radio voice of Carolina women’s basketball, teaches the class to help students sharpen their skills, using his experience with the Tar Heels and calling games for ACC Network and ACC Network Extra. “There is no substitute for live reps, and that is the only way you get better. The classroom component teaches you how to get better, but going about that requires sitting in that chair, making mistakes and being able to know your broadcast is going somewhere,” Krause said. “These students are doing real live games, and they will have tape where if they want to pursue this. They will have ready-made demos to send for jobs. Being able to utilize all the resources of UNC, GoHeels Productions and the Carolina Athletics brand and create these opportunities for students is really impactful.” In the class, students learn fundamentals like how to announce starting lineups for different sports and how to conduct research before games. Krause has led the class in mock preparation exercises, looking at game charts with information about the different teams and players that they can refer to at pivotal moments during the game. Krause and the students then critique each other, listening to clips from the past week to find ways to improve. It’s a rare class without a slew of quizzes or assignments. Their main tasks are calling games and making a portfolio or demo reel of their best calls at the end of the semester, all with the goal of being ready to step into similar roles after graduation. Laible live streams her coverage on the GoHeels website. Calling a live game while broadcasting her coverage allows her to get hands on experience. (Jon Gardiner/UNC-Chapel Hill) Junior Anna Laible ’27 wished for a class just like this. Her first year at Carolina, she interned with the Coastal Plain League, where she was introduced to play-by-play for baseball. “I enjoy the challenge and uncertainty of each game being different because each sport looks a little different,” said Laible. “Each game is different — not just with teams but what could happen with certain records being broken or random trends. That’s what I enjoy most.” She wanted more opportunities for reps during college to prepare for a career after Carolina, so she pitched an idea for the class to Livis Freeman ’99, distinguished associate professor of sports communication. Laible and Freeman reached out to GoHeels Productions for a partnership and then connected with Krause. “This is how at UNC Hussman we separate ourselves: Our students go into the field ready,” said Freeman. “The biggest compliment we get it is when our students start their careers, they don’t need any hand-holding.” Laible calls a Carolina softball game at Kessing Stadium – after pitching the idea to Hussman faculty. Her interest in sports commentary allowed her to apply her interest as she attends Carolina. (Jon Gardiner/UNC-Chapel Hill) Laible is now a student in the class, which has helped her strengthen her skills and deepen her passion for the field. The goal is to expand to other sports like soccer, lacrosse and field hockey. “The hands-on experience I’ve gotten here is invaluable. I’ve loved the classes and professors because they’ve taught me a lot, but it’s also the things outside of class, too, that have helped me grow,” said Laible. “Since being at UNC, I’ve grown a lot in the versatility, from doing writing to production and commentating. UNC Hussman and Carolina have given me the ability to be strong and well rounded.”
Community event highlights local artists, entertainment in Lima
A new community event, 419 Day, will bring live entertainment, vendors and artists to downtown Lima this Sunday. Organizers hope the event encourages residents to support local talent while enjoying
Chris Paul dances on Clippers' grave with meme after former team's play-in collapse vs. Warriors
Chris Paul enjoyed his former team's brutal loss on Wednesday.
Five players miss Arsenal’s training ahead of the Sporting game
Arsenal are set to face Sporting Club in the Champions League in a matter of hours, but concerns are growing over the potential absence of several key players. The Gunners have enjoyed an impressive s...
Champions League live updates: Bayern-Real Madrid, Arsenal-Sporting CP
Enjoy all the updates from the UEFA Champions League quarterfinals Wednesday, which see Bayern Munich taken on Real Madrid and Arsenal battle Sporting CP.
After-hours business expo in Carteret County
Meet and greet with 65 exhibitors, take part in speed networking sessions, buy into the 50/50 cash drawing, and enjoy hors d’oeuvres, beer, and wine as you work the room.
From a massive living area to an entertainment room and art collection: Ram Kapoor’s approximately Rs 20 crore Mumbai house
Ram Kapoor enjoys a lavish lifestyle in Mumbai with wife Gautami and kids. He once gave a glimpse of his luxurious Mumbai house in a Farah Khan’s vlog. The house is worth around Rs 20 crore and includes an entertainment room, bar and much more. Here’s a look at his lavish Mumbai house:
Fund science, downtown living expensive, protect America
I enjoyed reading the article about how Artemis II “captivated Americans young and old across political divides, bringing unity of wonder, hope and pride to a nation torn by partisan
Liam Rosenior “under severe pressure” says Sky Sports pundit who is worried for coach’s future
Liam Rosenior is “under severe pressure” to beat Man U this weekend, but his team get “beaten up” when they play big teams.If you enjoy Chelsea News coverage and want to see more of it, add us...
How Audrey Hepburn impacted fashion, entertainment and even World War II
“The most important thing is to enjoy your life. To be happy. It’s all that matters,” Hepburn once said. If one is to follow her example, then a life of fashion, elegance, creativity, advocacy and kindness is a life to be enjoyed.
Column: As ‘Soccer Dad’ can tell you, today’s youth sports are no simple fun and games
“Soccer Dad” is an enjoyable, enlightening and charming new book about David Murray’s journey into the youth sports world with his daughter Scout.
In Leo, Trump Faces a Different Kind of Papal Opponent
Unlike his predecessor, Pope Leo XIV enjoys growing support from a broad swath of conservative Catholics.
Here\'s the performance schedule for Marietta\'s Cherry Blossom Benefit Music Festival
Enjoy musical acts under a stretch of 150 cherry trees in full bloom when Marietta’s Cherry Blossom Benefit Music Festival returns Saturday, April 18.
Manchester United vs Leeds – Match preview and team news
Manchester United host Leeds United on Monday night to conclude the Premier League action of the matchweek.The Red Devils have enjoyed a remarkable transformation under Michael Carrick since January. ...
It's music festival season. How to stay safe and healthy while enjoying the show
Music festival season is here, bringing outdoor fun, music and dancing | Talk 1370
It's music festival season. How to stay safe and healthy while enjoying the show
Music festival season is here, bringing outdoor fun, music and dancing | WWL
It's music festival season. How to stay safe and healthy while enjoying the show
Music festival season is here, bringing outdoor fun, music and dancing | KCBS All News 106.9FM and 740AM
China, Iran weaponized the global economy to beat the U.S. at its own game
Washington once enjoyed a near monopoly over this type of economic warfare, but now American consumers and companies are starting to feel the pain.
Seniors: Dennis Ouellette, 80
Ontario Orchards owner not slowing down as he grows his farm market By Stefan Yablonski The seeds for Dennis Ouellette’s career path were sown when he was 6 years old — and he isn’t slowing down. “Since age 6, I grew up an agriculturalist. That is 72 years. Started out with a 37-acre farm when I bought it from my parents and built it up to almost 300 acres. Brought it back down to around 200 acres now,” he said. The location of his business was just a barn, a horse barn, he said. “In 1967, it officially became Ontario Orchards Farm Market. My wife [June] and I graduated [high school] in 1964 and three years later we became Ontario Orchards. We have been here more than 60 years,” he explained. “It is the same location. We have expanded over the years as the customers mentioned different things; we have expanded to bring in different products. “What keeps me going is I totally enjoy what I am doing. I enjoy the people that I work with. The customers are wonderful. Mostly, more important than anything, is my family — my wife, my daughters, grandchildren, son-in-law — we are still very much a family business I’m not going to retire just yet.” He also enjoys the changing seasons. “Ontario Orchards is a four-season business. There is always something new; more energy, more interest. Not only for the business but for my staff, the people that work here. Things keep changing, changing. We are always looking forward to something new and exciting,” he said. They work with quite a number of local farmers within the area and throughout the state, throughout the country and from around the world.” “We do have things from different countries around the world. But specifically, we are very excited about the local. We have an over 200-acre farm. We sell just about everything we raise on that farm right here at the farm market. For example, we press cider year-round. We make baked goods every day, year-round. We sell our apples 12 months a year.” “Today, there are so many products in Ontario Orchards that we never would have thought of in 1967,” he continued. “I attribute a lot of that to my daughters. I like the young blood and new energy. That is very crucial to a business, it keeps it vibrant.” What’s his favorite part of the job? “I don’t have a favorite part. I enjoy it all. I have a lot of intertest in other things,” he said. “I have staff that knows so much. I can go to the staff and say, ‘I don’t know what this is, you tell me what this is.’ They are so knowledgeable. It is impossible for one person to know everything in this place. In the summer, staff is about 60; in the winter about 20, 25.” He added that he plans on being around for several more years.
Seniors: John Lemp, 70
Has been working for more than 50 years in the business — M. Lemp Jewelers in Syracuse — that his great-grandfather started in 1890 By Mary Beth Roach Don Lemp owns and represents the fourth-generation of the family business, M. Lemp Jewelers, but he still calls himself “a counter guy.” “I love interacting with couples. It’s a wonderful business. You’re celebrating marriages, engagements, births, anniversaries — all these different significant moments that people invite you into their lives for whatever brief period of time it might be to help them celebrate whatever their important occasion is,” he said. This is one of several reasons why Lemp, at 70, has been working for more than 50 years in the business that his great-grandfather started in 1890. Always located in the downtown Syracuse area, the store has been situated in the building that the family owns on East Fayette and Warren streets since 1971. He jokes that he’s been in the business so long he is now selling engagement rings to the second generation in some families. He also loves the opportunity to learn about the ever-changing industry and gemstones. “You have to know not only diamonds, but all the colored stones, from A to Z, from andalusite to zircons,” he said. Lemp said he had originally thought he wanted to become an attorney, but while working part-time in the store while attending college at Syracuse University, he decided to follow in the family business. His father, Walter D. Lemp Sr., and his mother tried to discourage their son from pursuing retail, reminding him of the hectic hours and lifestyle intrinsic in this business. But the younger Lemp [whose full name is Walter D. Lemp Jr.] prevailed. So, over the years, father and son got to work together in the family business for 35 years. And while many other jewelers retreated from downtown to suburban malls in the 1970s, the Lemps decided to stay downtown. And it’s a decision that Lemp Jr. feels it has worked out well. As he explained, downtown Syracuse is seeing a rebirth. One website, Point2Home.com, has noted that more than 6,000 people live there and the median income is about $62,000. In addition, according to the website that Lemp built years ago, the store can cater to customers throughout the country. His customers, whether from across the country or across Onondaga County, are just one reason that Lemp stays engaged in the business. His employees, the opportunity to continue to learn in an industry, and the challenge to continue to improve business are all other reasons, he noted. He’s also been able to travel to India to buy diamonds and he enjoys buying and selling estates. “I’d rather gallop in the corral than ride into the sunset,” Lemp said.
Seniors: Carol Watson, 72
Owner of Carol Watson Greenhouse and Landscaping in LaFayette enjoys her growing business — still puts in six-, seven-day weeks By Mary Beth Roach Carol Watson, the owner of Carol Watson Greenhouse and Landscaping, has been in gardens since she could walk. Literally. She said she learned to walk in her grandfather’s garden, which was next door to her current home and business in LaFayette. Today, at 72, she is running the business that her mother, Claire, opened in 1981 as Watson Greenhouse. Watson worked part-time for her mom until 1990, when she joined her full time. While she may not have had any formal horticultural experience, she said she learned so much about growing and raising plants from her mom, who had an abundance of energy and talent. Now, after 35 years in the business full time, Watson has no plans to retire, although she joked that she’d like a couple of days off a week. On her seven-acre site, complete with four greenhouses, Watson said her favorite parts of the job are working with and educating her customers; helping some of her young customers build terrariums; conducting occasional class field trips; and supporting local art by decorating the shop with an eclectic mix of pottery from at least four area craftspeople. A one-time employee of the former Dey Bros. department store in Syracuse, Watson said she loves merchandising and enjoys displaying unique pieces of art on shelves and even suspending from ceilings. “We’re creative. We also had top quality plants. We got a reputation of quality plants and unusual products,” she said. It’s tending to her customers and her plants, showcasing the unusual products, and hosting special events to benefit the community that keep her motivated to work six to seven days a week. “I just love it. I love taking care of the plants. I’m one of the few people that really enjoys watering,” she said. And while she has cultivated a solid customer base over the years, she remains savvy in her marketing efforts to draw in new customers. For example, she does a gardening segment on CNY Central television; her active Facebook page has thousands of followers; and she hosts a number of unique events and classes that not only introduce her shop to potential new clients, but some benefit nonprofits as well. About 13 years ago, when the local symphony orchestra was struggling, she said she wanted to help. So, partnering with the group, she began offering concerts, called Soirees, featuring the Syracuse Orchestra’s string quartet. Following up on a suggestion from a customer whose brother is a deejay in retirement, specializing in sock hops, she hosted the greenhouse’s first sock hop. Plants got moved back toward the walls to make room for dancing; a caterer was brought in, offering diner-like food; guests came in period outfits; and proceeds went to the Food Bank of CNY. She is excited about doing it again in October. Via her website, she promotes the greenhouse as an “oasis in the snow,” offering visitors the opportunity to pick up some decorating and gift ideas while taking in the floral and citrus scents. And she also caters to her four-legged friends. Over this past winter, she said, she came up with a “brilliant idea,” although at the time she didn’t appreciate just how brilliant it would become. Feeling it too cold outside to take her dog for a walk, she opted to bring it into the greenhouse. And before long, she was inviting people to bring their dogs into the big greenhouse as well. She looks forward to extending that invitation again this upcoming winter season. For Watson and her customers, the greenhouse is always in season.
Amazon Luna Removing Paid Games And Offering No Refunds
You have until June 10 to enjoy the games you purchased on the cloud streaming service
Sue Serino Invites Seniors to Learn Laughter’s Health Benefits
Dutchess County Executive Sue Serino and the County’s Office for the Aging (OFA) invite older adults to enjoy an uplifting and engaging afternoon focused on the health benefits of humor at “Spring Into Happiness: Laughter Edition."
Netflix's 'Thrash' is junk-food entertaining to roast, mock and enjoy
From the director of “Violent Night” (Tommy Wirkola), “Thrash” is Netflix’s first summery film of the year. In 2026, you can’t simply have a natural disaster movie or a predator
North Dakotans can learn about resources to grow healthy habits on April 18 at Gateway to Health event | Health and Human Services North Dakota
Individuals and families are invited to the fourth annual Gateway to Health community event, which includes activities for all ages on Saturday, April 18, 10 a.m.- 4 p.m. at North Dakota’s Gateway to Science in Bismarck. Participants will enjoy free access to the science center during their registered two-hour time slot, along with access to interactive booths and exhibits promoting health and wellbeing through hands-on activities, games and prizes.
HOMETOWN ENTERTAINMENT: Weekend entertainment guide: Comedy, music and spring festivals
Enjoy a variety of events this weekend, including stand-up comedy, dance parties and a spring festival
Another Big Night for Democrats: Tuesday’s Wisconsin and Georgia Results
Democrats enjoyed another double-digit victory in a Wisconsin state Supreme Court race; their win will expand the liberal majority on the body to 5-2. Meanwhile, Republicans held GA-14, although it made for another Democratic overperformance.
13th annual Tuck Entertainment Easter Egg Hunt brings joy - WNKY News 40 Television
FRANKLIN, Ky. – Hundreds of children and families gathered in Franklin, Kentucky for the 13th annual Easter Egg Hunt by Tuck Entertainment at Lincoln Park. Kids flooded the park and enjoyed the free family event. There were prize giveaways, free haircuts and so much more. However, the main goal was to share the reason for the season, and that’s their...
Kids will spring into science with April’s Parents’ Night Out at DHDC
From 5:30 to 9:30 p.m. on Friday, April 10, the Don Harrington Discovery Center is offering a chance for children ages 4-11 years old to crack into hands-on experiments while caregivers enjoy an evening to themselves.
The Chamber Corner: From startup to legacy: Strengthening family businesses in Worcester
One of the most enjoyable aspects of my role as president and CEO of the Worcester Regional Chamber of Commerce is to witness how our chamber team assists individuals in launching their businesses.
Double Dragon Creator Yoshihisa Kishimoto Has Passed Away
"I hope you will continue to enjoy my father's works"
Why the controversy with mail-in ballots?
Most Coloradans enjoy the right to vote “by mail” at election time. Most Americans favor this process. But U.S. President Donald Trump is trying to federalize (nationalize) this practice and shift the supervision of voting from county clerks to the Department of Homeland Security and the U.S. Postal Service. He issued an executive order to […]
Head to Key City in April to enjoy live rooftop music
VICKSBURG, Miss. (VDN) — April is bringing the vibes to the rooftop! Join the group at Key City Rooftop for a month of great music featuring talented local and regional artists. Whether you want to sit back and enjoy the sounds or jump in and be part of the action, Key City has you covered—bring your […]
“I couldn’t enjoy it fully until now”: Crimson Desert’s once‑exclusive PS5 mode finally arrives on Xbox — and I’m ready to dive back in
Crimson Desert’s 4K update arrived on PlayStation 5 first, leaving Xbox Series X users waiting, with Pearl Abyss declining to explain the temporary lack of parity.
Portland warns outdoor dining setups could pose health risks without proper maintenance
If you are planning to enjoy the warm weather by dining outside, you might want to check before you take your seat.
A retired grandpa thought he was in good health — until he fainted during a bike ride
John Cantrell was enjoying his retirement until an unexpected condition forced him to choose between two kinds of heart surgery.
‘This is a recalibration’: Trump Cabinet worries no one is safe after Bondi and Noem firings
When President Donald Trump ousted his attorney general, Pam Bondi, it sent a clear message to his remaining Cabinet members: The job security they’ve enjoyed until now is no longer guaranteed.
Kids, Competition & Pressure: Keeping Sports Fun
How can parents help their children enjoy the game without feeling overwhelmed?
Do your kids play sports? Here’s how to keep it fun and stress free
The American Academy of Pediatrics reports 40% to 50% of youth athletes feel stressed by sports-related expectations. So how can parents help their children enjoy the game without feeling overwhelmed?
Celebrate Science Day Takes Off at New Location: Reading Regional Airport
From helicopters to birds and the principles that lift them skyward, guests of all ages will discover how things fly while also enjoying a wide range of interactive STEM activities beyond aviation.
GTA+ Members Can Claim a Free Bravado Buffalo STX Pursuit Law Enforcement Vehicle
Get behind the wheel of the aggressive Bravado Buffalo STX Pursuit Law Enforcement Vehicle now available to GTA+ Members one week before everyone else on April 9. Enjoy other great benefits including bonuses for Dispatch Work and Bail Office Bounties,...
LA Chargers help high school athletes learn lifesaving CPR
More than 250 high school student-athletes from across the Los Angeles Unified School District spent a day learning about heart health alongside Los Angeles Chargers players.Students learned hands-only CPR, met Chargers players Elijah Molden and RJ Mickens in UCLA Health Sports Performance Training, Powered by Exos, and enjoyed lunch on the patio at Huddle for Heart Health, held March 19 at The Bolt, the Chargers’ official practice facility in El Segundo. RJ Mickens, left, and Elijah Molden joined more than 250 LAUSD high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Along with learning CPR techniques, students practiced performance training on the LA Chargers practice field in El Segundo. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) LA Chargers defensive back RJ Mickens visits with high school students at the Huddle for Heart Health event. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) The event was presented by UCLA Health, the American Heart Association, the Los Angeles Chargers and LAUSD.Hands-only CPR is a lifesaving skill, said David Sato, MD, board president of the American Heart Association Los Angeles.“We save more lives when we work together,” said Dr. Sato. “This collaboration with UCLA Health and the Los Angeles Chargers to teach students how to perform hands-only CPR helps ensure more families in Los Angeles have someone ready to act in a cardiac emergency when seconds count.”Hands-only CPR is a lifesaving procedure for cardiac emergencies that doesn’t involve rescue breaths. It involves pressing hard and fast in the center of the chest of a teen or adult who has collapsed. Pressing can be done to the beat of the Bee Gee’s hit “Stayin' Alive, which, at 100 beats per minute, is the minimum rate at which to push during hands-only CPR, according to the American Heart Association. LA Chargers defensive back Elijah Molden, standing, helps high school students learn CPR skills. (Photo courtesy of Joaquin Torre/Los Angeles Chargers) Most cardiac arrests that don’t happen in the hospital happen at home, and hands-only CPR is as effective as CPR with breaths in the first minutes following a cardiac emergency.
UCLA women enjoy 'home-court advantage' during Final Four run
Predicting spring bloom is an art
Do you ever wish you could predict the future? The National Park Service in Washington D.C. does it every year when they forecast when the Capitol’s cherry blossoms will reach peak bloom. People travel from all over the world to enjoy the annual National Cherry Blossom Festival and to glimpse these fragile flowers before they are gone. On this month’s Nature Quest, we learn the ins and outs of cherry tree blossoms, how scientists make that big prediction every year — and why all this focus on blooms can help scientists better understand climate change. This episode is part of Nature Quest, our monthly segment from listeners noticing a change in the world around them. To participate, send a voice memo to shortwave@npr.org with your name, location and your question about a change you're seeing in nature!Want to learn more about nature’s calendar? Check out our first Nature Quest episode on whether flowers are blooming early.Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.
Sunday Science: The return of the ruby-throated hummingbird
As spring starts to sprout in Southern New England, birdwatcher's have plenty to look forward too. Turning the calendar to April means that the ruby-throated hu
Runners enjoy the Visit Tuscaloosa Half Marathon and DCH Health System 5K
Check out the photos of runners in the DCH Health System 5K and the Visit Tuscaloosa Half Marathon.
Gambling is entertainment — taxpayers shouldn’t foot the bill for losses.
The tax code should make clear that activities fused with fun, excitement and personal enjoyment are never an occasion for a tax deduction.
Everything You Missed at Shop TODAY Stages 2026 Health & Wellness Summit
Guests enjoyed a day full of expert chats, pampering and, of course, plenty of free products.
New Congressional bill targets sports team relocations
More than 40 years after the Colts left Baltimore for Indianapolis like thieves in the night, those in a profession that enjoys nearly the same level of respect are trying to prevent it from happening again.
PWHL Takeover Tour in Detroit as women's hockey rides Olympic high
Women's hockey is enjoying a wave of interest thanks to USA's victory at the 2026 Olympics, a boost for the PWHL.
Weekly Entertainment Report for Southern NH, March 26-29: Live music and lively arts
Live music and the lively arts connects us to the human experience. Go forth and enjoy what is waiting for you.
Broad Ripple welcomes new sports, entertainment venue
BROAD RIPPLE, Ind. — The Broad Ripple neighborhood will soon be home to another place where people can enjoy fun and food. Stick & Hack Entertainment is opening its second location at 46th Stre…
Hands-on science program brings STEM to life at Mass. school
The school's 5th graders enjoyed a special science lesson by Preeti Mostello, an educator with the nonprofit Traveling Science Workshops from the Discovery Museum in Acton.
Play It Again Sports (Arkansas Sports University Inc.) - Talk Business & Politics
Cameron Campbell always enjoyed playing sports. His two favorite sports were basketball and baseball. When he got out of school, he wanted to do something where he was still involved...
MY HERO ULTRA RUMBLE : Patch Notes 1.15.0
Through our maintenance update on March 25, 2026, we made the following changes. New features, System Adjustments, Adjustments to Area Control Battle, Battle Style Adjustments, Bug fixes... We hope you continue enjoying MY HERO ULTRA RUMBLE.
‘The Price Is Right’ Nurse Speaks Out After Winning a Car
'My goal was just to enjoy the day and come what may.'
UMaine sports management students enjoy networking trip to Indiana
Westfield’s Droplight Grand Park Sports Campus, more Indianapolis-based experiences
Marathon has sold 1.2M copies across Steam, PS5, and Xbox
Alinea Analytics estimates show that Marathon has generated gross revenues of $55M via 1.2M copies sold on Steam, PS5, and Xbox: Looking at the split between Steam, PS5, and Xbox, Steam is clearly the main platform for Marathon, accounting for a little under 70% of the audience (800K copies sold). Meanwhile, PS5 takes about 19% (217K) and Xbox (including console, PC, and cloud) accounts for a bit over 11% or 133K. Marathon is technically a first-party Sony title, so seeing the home console struggle to break 20% of the volume is a notable data point for the ongoing platform-agnostic debate. PlayStation Studios online games will almost certainly continue being multiplatform (despite Sony reportedly pulling back on PC releases). Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe As for Marathon, the consensus among hardcore players who pushed through the awkward onboarding phase – myself included – is that it’s fantastic. The gunplay, aesthetic, and presentation are among the best in the shooter genre. A great game doesn’t always equal an immediate hit, though, as shown by our estimates. Things are looking lukewarm right now. But this might be one of those marathon-not-a-sprint situations. Had to, didn’t I? Why wasn’t Marathon a hit on the same level as Arc Raiders? One topic that came up in a lot of conversations at GDC this year was why Marathon hasn’t hit the same stratosphere as Arc Raiders. On paper, they’re both extraction shooters, and Marathon has the Bungie pedigree – the house that built the gold standard for gunplay in Halo and Destiny. Marathon’s neon-futuristic aesthetic also distinguishes itself from the gritty realism of Tarkov or the post-apocalyptic hope of ARC Raiders. But vibes can only get you so far for first impressions if the onboarding feels like a brick wall. Marathon is a sweaty PvP-focused experience with a first-time user experience and UI that I can only describe as dreadful. Players are dropped into a complex ecosystem where the UI, though visually striking, is functionally uninformative, forcing users to manually hover over nondescript, identical icons just to identify basic gear or weapon mods. This lack of clarity is compounded by punishing mechanics like a severe heat gauge for movement and a scarcity of vital resources, all without a clear tutorial or a low-stakes mode to learn the ropes. Most people – even top streamers and veteran shooter players – have no idea what’s going on in Marathon at first. Arc is on the complete other end of the spectrum. As we covered here and here, Arc Raiders offers a more collaborative, approachable loop where players often work together toward shared goals. And the objectives are instantly clear. To many players, this contrast only emphasised Marathon’s issues, especially during the testing period. Players understand the Arc Raiders loop within 30 minutes, while Marathon acts as a massive filter, chewing up newcomers and spitting them out before they can experience the depth of Bungie’s signature gunplay. What I’m getting at here is that the poor first-time user experience of Marathon’s Server Slam likely stifled launch sales, while the opposite was true for Arc. Let’s look at the pre-launch copies sold for each game during their respective Server Slams (launch-aligned) : Looking at the trajectory: Arc Raiders saw a massive 80% jump in copies sold during its three-day Server Slam (day -13 to -11). Players jumped in, realised the water was fine, and immediately opened their wallets. Marathon, meanwhile, saw a 49% increase in the four days following its Slam (Day -7 to -3). At the time of each game’s respective launch, Arc Raiders had nearly double the Steam footprint of Marathon – and word of mouth only continued to grow. Bungie could have had more time to fix the onboarding process had the beta happened earlier. But Marathon launched three days after the beta finished. These factors limited the launch sales quite a bit, I reckon. Marathon has found a niche audience, though Despite the friction-heavy start, the data suggests that those who survived Marathon’s onboarding are loving life. We’ve been tracking cross-platform DAUs, and while there’s the expected post-launch leakage, many players are sticking with it. After peaking at 478K total DAUs on its first Saturday, Marathon has settled into a respectable rhythm, holding 345K DAUs as of yesterday and averaging 380K DAUs across the weekend. Steam continues to do the heavy lifting here, consistently accounting for the lion’s share of the daily players. Players have been putting in the hours, too: On Steam, Marathon’s average playtime has climbed to 27.8 hours, significantly outpacing the console averages on PS5 (16.5h) and Xbox (17.3h). Even more telling than the averages: 22% of the Steam audience has surged past the 50-hour mark, and nearly 7% have already logged over 100 hours. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe This data suggests that once the Bungie magic clicks, it hooks players deeper than the average extraction shooter. There’s also started to be a shift in the game’s discourse. Marathon launched as one of those games that’s cool to hate. But as Marathon’s 100-hour club grows, we’re seeing conversations around its mechanical merit outweigh the negativity. Several high-profile creators, who were initially vocal critics, have spent the last week coming around on the mechanical depth of the endgame. It’s a subtle but positive signal; the hate train is losing steam, and a new narrative about the game is emerging. Bungie faithfuls unite Another interesting metric in Marathon’s first few weeks is who, exactly, is playing. Bungie leans heavily on its prestige as the “makers of Halo and Destiny,” in its marketing, and that message has clearly hit the mark. On Steam, the gravity (hammer) of Bungie’s previous work is unavoidable. A staggering 78.2% of Marathon players also played Destiny 2. The trend carries across other platforms, with 74.2% of PS5 players and 82.7% of Xbox players also having played Destiny 2. The Halo legacy lives on, it seems. More on that in a bit. While Destiny 2 went free to play, these numbers still represent a high-intent migration of a fanbase that trusts Bungie’s specific brand of kinetic gunplay and cryptic world-building. The Xbox data adds another layer of legacy. About 85.7% of Marathon players on Xbox have played Halo Infinite, while over half of the Steam audience has spent time in Halo Infinite and 36.1% in the Master Chief Collection (a paid collection of the old Bungie-made legacy games). Interestingly, we see a 55.9% overlap with ARC Raiders on Steam. Overlap is even higher there on PlayStation (60.5%) and Xbox (66.5%). And there’s also significant crossover with Helldivers 2 on all platforms, too. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe Bungie has found some of its fans with Marathon, and the challenge now is keeping this engaged in a high-stakes PvP environment when they’ve spent the last decade primarily enjoying the power fantasies of PvE. On that note… Go the full 26 miles? Or cut and run? Time for some could’ve, should’ve, would’ve. These things would have improved Marathon’s performance at launch: A more robust onboarding process, perhaps in the form of a short single-player/PvE campaign. We know Bungie fans love this stuff. A traditional arena-based mode akin to Destiny’s Crucible could have been a bridge for the cautious players who’d have been otherwise deterred by the Server Slam. It’s also a great palate cleanser after getting merked. Introducing a dedicated PvE environment would have similarly diversified the conversation and lowered the barrier for the Bungie faithful who found the pure PvP extraction loop too abrasive. PvE is safer than PvP these days. There’s an argument that a thin PvE mode would have just felt like a budget Destiny, potentially hurting the brand more. But given how dire the FTUE is, I think it would have been a net positive. Any kind of tutorialised loop that demystifies the stakes, really. While there is merit in a studio sticking firmly to a singular creative vision, and going all in on the hardcore extraction loop. Less forgiving is the technical reality is that the user interface and first-time user experience (FTUE) were not at a commercial standard for launch. Subscribe for free to get the most accurate games estimates in your inbox twice a week 🫶 Subscribe In a landscape where player time is oversaturated and the most contested currency, a flawed FTUE is a critical failure point. But it’s not all doom and gloom, as Marathon has an incredible, unique gameplay loop, suggesting that financial success is still attainable if Bungie can pivot effectively. Bungie and PlayStation now face a difficult strategic crossroads, though – one within a challenging games market. They could: Double down on Marathon with a long-term Rainbow Six Siege- or No Man’s Sky-style recovery plan, which is something I heard Last Stand Media’s Chris Maldonado mention last week. While this could be a sunk-cost fallacy in action, it could eventually yield the audience the game’s mechanical depth deserves. Shift focus toward the inevitable Destiny 3 or another project, mitigating the escalating opportunity cost and cutting their losses, so to speak. Doing both is an expensive proposition, given the high overhead and burn rate of operating out of Bellevue, Washington. With Sony recently demonstrating a lower threshold for underperforming studios and projects, the margin for error has vanished. Whatever happens, the next six months will determine whether Marathon becomes a cornerstone of Sony’s live-service portfolio or a cautionary tale of vision exceeding accessibility. I’m hoping it’s the former, because Marathon rocks. As always, hit subscribe to get updates on Marathon and other relevant games. Subscribe Want to get your hands on our data for yourself – for free? We’re offering a free trial of our platform for games companies. Send us a message here, or reply to this email, and we’ll set you up. The last word Reply to this email – or reach out here – if you have any feedback for the newsletter – or want to request a game for us to cover. [Alinea Analytics boasts the most accurate PC and console estimates in the business. Game makers use our platform to understand their audience, keep an eye on the competition, monitor sales trends, and spot new opportunities. We equip game studios and financial institutions with accurate data and the confidence to make smarter, data-driven decisions. Want to talk about all things games market data? We’d love to chat!]
Live Entertainment on Local Stages this Spring
Warmer weather, blooming flowers, and extra daylight aren’t the only seasonal delights to enjoy this spring. There’s also a whole new crop of live entertainment! Here’s what you can see on s…
From elections to redistricting, Jenna Persons-Mulicka’s footprint grows in the House
For now, though, she’s enjoying a break from action back home with her sons.
We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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