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Jack Osbourne grew up on MTV. Now his 14-year-old daughter wants in.

Jack Osbourne on growing up on camera, raising five daughters and the advice he carries with him from his late father, Ozzy.

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Oct 26 • 3:46 PM EDT • Entertainment • yahoo.com
Gov. Wes Moore, up for reelection in Maryland, campaigns in Virginia

With victory expected at home, Moore is wooing Black and veteran voters in a 2028 early presidential primary state.

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Oct 26 • 3:24 PM EDT • Politics • washingtonpost.com
Baltimore County flower shop announces closure after over a century in business

Dundalk Florist, a Baltimore County flower shop that has served the community for 115 years, will close its doors in November. The shop thanked the community for its support.

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Oct 26 • 3:12 PM EDT • Business • wbal.com
Jenny & Dave Marrs Share Health Update on Former ‘Fixer to Fabulous’ Guest

The couple also shared ways fans can support the guest and their family.

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Oct 26 • 3:08 PM EDT • Health • yahoo.com
Knicks' honeymoon phase over already? Behind the champs' slow start
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Oct 26 • 3:06 PM EDT • Sports • sports.yahoo.com
Lula bucks regional shift to the right and denies Trump a powerful ally in Brazil

Brazilian voters have denied Latin America’s resurgent right its ultimate prize. Lula's reelection limits U.S. President Trump’s influence in the region and cements Brazil as a counterweight to Washington.

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Oct 26 • 2:48 PM EDT • Politics • pbs.org
Trump calls Senate nominee El-Sayed a ‘jihadist’ at Michigan rally

President Trump repeatedly called Democratic Senate nominee Abdul El-Sayed a “jihadist” during a campaign rally in Michigan on Sunday, urging his supporters to fight El-Sayed’s run in the same way Americans battled terrorists on 9/11.

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Oct 26 • 2:14 PM EDT • Politics • washingtonpost.com
OKC’s traumatic injury, small sample theater & Texan teams with Slightly Biased
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Oct 26 • 2:13 PM EDT • Sports • sports.yahoo.com
Thune campaigns for Republicans in marquee Senate races in scramble to save majority

Republican candidates in marquee Senate races have welcomed Thune's help as he’s traveled around the country in the weeks before the midterm elections, scrambling to save his majority.

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Oct 26 • 2:06 PM EDT • Politics • pbs.org
Heidi Klum, Queen of Halloween, teases this year’s ‘bloody’ costume

Each year, Klum unveils her full costume at her star-studded costume party on Oct. 31 in New York City.

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Oct 26 • 1:57 PM EDT • Entertainment • yahoo.com
Professor explores a ‘Perfect Storm’ of health misinformation risks

A new article coauthored by Dr. Matthew Morse, assistant professor of Communication Studies in Louisiana Tech University’s School of Human Inquiry, examines how health information risks develop and wh

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Oct 26 • 1:50 PM EDT • Health • latech.edu
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Trump accused of ‘manipulating’ Catholic bishops for political gain

Archbishop of Milwaukee says White House exploited clerics in Oval Office photo

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Oct 26 • 1:22 PM EDT • Politics • ft.com
Mets SS Francisco Lindor wins 2026 Roberto Clemente Award
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Oct 26 • 1:13 PM EDT • Sports • sports.yahoo.com
The science of being scared: What happens to your brain, body when fear strikes?

Screams, chainsaws and terrifying characters are all part of the experience at Halloween haunted attractions, but what actually happens inside our bodies when we get scared? Sister station KETV’s reporter Connor Schmidt put that question to the

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Oct 26 • 12:57 PM EDT • Science • wbal.com
Is the U.S. Bank Business Essentials Visa worth it for your small business?

The U.S. Bank Business Essentials Visa offers unlimited 2% cash back on eligible purchases — and up to 2.5% back with an eligible U.S. Bank business checking account.

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Oct 26 • 12:17 PM EDT • Business • finance.yahoo.com
Google Brotli flaw exposes cloud environments at scale

90% of cloud environments have resources exposed by the Google Brotli flaw as patches roll out unevenly across key platforms. See what risks remain

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Oct 26 • 12:16 PM EDT • Technology • cybernews.com
Anthropic flags 'increasingly restrictive AI regulation' as a business risk

Anthropic says "increasingly restrictive AI regulation" could threaten its business.

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Oct 26 • 12:11 PM EDT • Business • finance.yahoo.com
ND Today: Business Highlight: ND Embroidery & Gifts

North Dakota Today

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Oct 26 • 11:52 AM EDT • Business • kfyrtv.com
Shake-ups and layoffs reveal a culture clash inside Netflix

LOS ANGELES -- As Netflix grapples with fallout from historic layoffs and upheaval in its senior executive ranks, the streaming giant is facing mounting scrutiny from investors about its growth

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Oct 26 • 11:45 AM EDT • Entertainment • recorderonline.com
Build-a-manager: LL staff edition

Sweet Lou aside, making a list of some qualities that are the most important to the LL staff in a manager

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Oct 26 • 11:45 AM EDT • Sports • sports.yahoo.com
Bon Secours Mercy Health to acquire majority stake in Surgery Partners in $5.7B deal

Bon Secours Mercy Health is acquiring a majority share in healthcare services company Surgery Partners in a take-private deal valuing the acquiree at $5.7 billion, the organizations announced Monda | The pending deal values the short-stay surgical platform at $5.7 billion, and is the latest example of large health systems' push to build out their ambulatory networks.

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Oct 26 • 11:37 AM EDT • Health • fiercehealthcare.com
Trump promised to stop inflation. Now Republicans may pay the price in the midterm elections

Voters blame Trump, pointing to the Republican president's tariff policies and the war he started with Iran.

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Oct 26 • 11:27 AM EDT • Politics • pbs.org
🙂 Positive (35%)
Joe Buck and Troy Aikman could be headed for a split. Why that matters more than you think
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Oct 26 • 11:20 AM EDT • Sports • sports.yahoo.com
Rhode Island FC and Centreville Bank Stadium Name Lou DePaoli as President of Business Operations

Seasoned sports executive brings over 30 years of leadership experience, deep New England roots to Rhode Island FC and Centreville Bank Stadium PAWTUCKET, R.I. (Oct. 26, 2026) – Today, Rhode […]

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Oct 26 • 11:05 AM EDT • Business • rhodeislandfc.com
AGFA HealthCare Selected by Infirmary Health to Modernize Imaging Across Its Health System

Enterprise Imaging Cloud investment advances Infirmary Health's strategy to modernize imaging, simplify radiology workflows and create a scalable foundation for continued growth.CARLSTADT, NJ / ACCESS Newswire / October 26, 2026 / Infirmary Health has selected Enterprise Imaging Cloud (SaaS) to modernize its radiology imaging environment and establish a foundation for a broader Enterprise Imaging strategy across the health system.

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Oct 26 • 11:00 AM EDT • Health • finance.yahoo.com
Rhode Island FC hires Lou DePaoli as president of business operations

DePaoli said he intends to prioritize making Centreville Bank Stadium, which currently operates about 50 dates annually, a year-round entertainment destination.

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Oct 26 • 10:58 AM EDT • Business • sportsbusinessjournal.com
Thousands of observers from the right and left will descend on polling places to monitor the vote on Election Day

The effort among Democratic and nonprofit groups includes training volunteers to stand watch outside polling places and report activities they consider concerning.

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Oct 26 • 10:29 AM EDT • Politics • pbs.org
🙂 Positive (35%)
Serbia's populist strongman Vucic outplayed all his opponents. Then the students came

Vucic on Sunday blamed his defeat on foreign interference.

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Oct 26 • 9:52 AM EDT • Politics • pbs.org
NFL Monday Night Football preview: Cowboys can't afford to lose to this version of the Eagles
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Oct 26 • 9:32 AM EDT • Sports • sports.yahoo.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • kltv.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • 1011now.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • wsmv.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • wowt.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • live5news.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • foxcarolina.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • newschannel10.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • kbtx.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • wdbj7.com
Progress being made on Prisma Health Performance Center in Greer

FOX Carolina's Scottie Hunter has the details.

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Oct 26 • 9:26 AM EDT • Health • wbtv.com
In brief: Orlando Bloom, Elijah Wood joining 'The Gentlemen'

Netflix is rounding up more gentlemen. Tudum announced Orlando Bloom, Elijah Wood and Ed Speelers are joining stars Theo James and Kaya Scodelario for the third season of The Gentlemen, which is currently filming in the U.K. and Morocco. Also added to the series cast are Dexter Fletcher, Robert Carlyle and Bugzy Malone, who appeared in the 2019 film that inspired the Netflix series. Daniel Ings, who played the drug-addled older brother Lord Frederick “Freddy” Horniman to James’ criminal mastermind Eddie Horiman, told HATC magazine he will not return for the third season. Netflix has not confirmed this …The action-adventure series Fallout has inspired a new reality show. Prime Video has revealed Fallout Shelter: The Experiment, an unscripted competition inspired by the post-apocalyptic drama series and the video game universe. The show “invites everyday participants to test their aptitude for the apocalypse in Vault-Tec's state-of-the-art bomb-proof vault shelters," according to Prime Video. Contestants will “go head to head in a series of high-octane drills, psychological dilemmas and morally challenging behavior trials.” The winner walks away with a $1 million prize. Fallout Shelter: The Experiment will begin streaming in January 2027 … TNCMS.AdManager.render({region: 'fixed-big-ad-top-asset', slot: 1, fold: "above"}); Bravo renewed a slate of its reality shows ahead of Bravo’s Fan Fest on Saturday. New York-based In the City has been greenlit for season 2, while Next Gen NYC is coming back for a third season. For viewers seeking a little Southern charm, The Next Gen universe will be expanding with a spinoff based in Atlanta, and Southern Hospitality is moving forward with a fifth season. Premiere dates have not yet been announced … Copyright © 2026, ABC Audio. All rights reserved. Thank you for reading kmaland.comAt KMA, we attempt to be accurate in our reporting. If you see a typo or mistake in a story, please contact us by emailing kmaradio@kmaland.com.

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Oct 26 • 8:30 AM EDT • Entertainment • kmaland.com
Can a shampoo really fill in a thinning hairline? The science says barely. Our tester says otherwise.

After four months with Vegamour's $104 GRO+ Advanced Balancing Shampoo and Conditioner, our tester is recommending the shampoo to all her friends, but definitely not the conditioner.

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Oct 26 • 8:21 AM EDT • Science • health.yahoo.com
2026 Private Dining Guide

Corporate dining trends change with the times. Our annual look explores how restaurants and event planners are innovating in the space.

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Oct 26 • 8:06 AM EDT • Business • tcbmag.com
Scientists solve mystery of 1,000-mile cloud floating on Mars

Space enthusiasts and astronomers have been tracking one of the Red Planet’s most fascinating atmospheric mysteries for years: a colossal plume officially known as the Arsia Mons Elongated Cloud (AMEC). AMEC was first discovered in 2018 and quickly became one of the most elusive answers for scientists. Researchers have now resolved this mystery using the […] Read the original article here: Scientists solve mystery of 1,000-mile cloud floating on Mars

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Oct 26 • 8:00 AM EDT • Science • tech.yahoo.com
UN climate science body left in limbo without budget sign-off after deadlock

Stranglehold on funding for the IPCC follows push from fossil fuel-reliant nations to delay publication of global warming reports

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Oct 26 • 8:00 AM EDT • Science • ft.com
Original Xbox Achievements Begin To Show Up Ahead Of Official Rollout

Could this be the beginning of OG cheevos?

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Oct 26 • 8:00 AM EDT • Technology • purexbox.com
Walmart taps startup General Medicine to expand Better Care Services

Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace. | Walmart is teaming up with startup General Medicine to expand its Better Care Services, turning the digital healthcare platform into a more comprehensive healthcare marketplace.

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Oct 26 • 8:00 AM EDT • Health • fiercehealthcare.com
Man completes 12,000-mile walk across America’s four corners in Lubec for mental health awareness

WABI TV5 News at 4

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Oct 26 • 7:50 AM EDT • Health • wabi.tv
The science behind fear chasing

As Halloween approaches, some people are seeking out experiences that leave their heart racing.

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Oct 26 • 7:04 AM EDT • Science • wnem.com
A progress report on Aetna's efforts to bridge trust gaps with providers

Building stronger bridges between payers and providers will prove critical in addressing the biggest challenges facing healthcare: affordability and access. | Building stronger bridges between payers and providers will prove critical in addressing the biggest challenges facing healthcare: affordability and access.

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Oct 26 • 7:00 AM EDT • Health • fiercehealthcare.com
Dallas Cowboys vs. Philadelphia Eagles: How to watch Monday Night Football tonight, start time and where to stream
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Oct 26 • 6:35 AM EDT • Sports • sports.yahoo.com
We disagree about politics. But we see the same problems in health care.

Congress has several ways it can improve the industry.

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Oct 26 • 6:15 AM EDT • Politics • washingtonpost.com
We disagree about politics. But we see the same problems in health care.

Congress has several ways it can improve the industry.

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Oct 26 • 6:15 AM EDT • Health • washingtonpost.com
States move to take ultra-processed foods off the school lunch menu

The effort is backed by an uneasy alliance between the right-wing Make America Healthy Again movement and progressives, both motivated by concerns over food safety.

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Oct 26 • 6:00 AM EDT • Health • washingtonpost.com
Trump’s D.C. hotel is gone. Mar-a-Lago is now a GOP campaign cash magnet.

Republican campaigns, party committees and PACs have spent nearly $3 million at Trump businesses since his return to office, a Post analysis finds.

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Oct 26 • 6:00 AM EDT • Politics • washingtonpost.com
Free Agent Relievers the Cardinals Could Sign This Offseason

With a lockout looming, an offseason freeze between players and teams makes it even harder to predict the St. Louis Cardinals’ next moves. The franchise is seemingly continuing to slow-play its rebuild, with President of Baseball Operations Chaim Bloom not committing to any eye-popping moves after the club finished 76-83 in 2026. But even if …

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Oct 26 • 5:00 AM EDT • Sports • sports.yahoo.com
Voters’ rising ire at corruption plays central role in Texas Senate race

The race between Ken Paxton (R) and James Talarico (D) has revolved around the issue that’s a top voter concern, just behind the economy.

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Oct 26 • 5:00 AM EDT • Politics • washingtonpost.com
Trump’s name was everywhere in earlier Louisiana elections. What about this time?

Both Republican and Democratic candidates in Louisiana seem to avoid mentioning the president.

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Oct 26 • 5:00 AM EDT • Politics • nola.com
City Spotlight 2026

City Spotlight from the Orange County Business Journal explores Anaheim and Riverside: the projects, industries and leaders shaping each city’s economy.

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Oct 26 • 4:15 AM EDT • Business • ocbj.com
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Concordia University - 50 Years In

Concordia University Irvine marks 50 years: from 36 students in 1976 to 28,000+ alumni and $45 million in new, debt-free facilities. Explore the milestones.

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Oct 26 • 4:12 AM EDT • Business • ocbj.com
Pa., N.J. and Del. to kick off 2027 ACA health insurance open enrollment on Nov. 1 as health costs rise: What you should know

ACA customers may face higher premium prices for coverage next year, but insurance experts say most people still qualify for financial assistance.

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Oct 26 • 4:00 AM EDT • Health • whyy.org
AI cloud computing companies face ‘guppy-level death’, Elon Musk warns, as funding dries up

Rolling coverage of the latest economic and financial news

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Oct 26 • 3:33 AM EDT • Business • theguardian.com
Elon Musk says neoclouds are cooked, and SpaceX won't be buying them

The SpaceX CEO said many neoclouds will face "guppy-level death" because they lack alternative streams of revenue.

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Oct 26 • 1:37 AM EDT • Business • businessinsider.com
Raiders 'thinking about everything' after latest loss, including potentially starting Fernando Mendoza over Kirk Cousins at QB
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Oct 26 • 1:25 AM EDT • Sports • sports.yahoo.com
SpaceX secures $40B in financing for GPUs as Elon Musk warns of AI cloud industry consolidation

SpaceX closed $40 billion in debt financing for GPU purchases as Elon Musk warns AI debt markets have shut off access for most companies.

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Oct 26 • 1:09 AM EDT • Business • foxbusiness.com
High school sports roundup for Oct. 23-24, 2026

Friday, Oct. 23 Football Meadowdale defeated Lynnwood 48-0 The Meadowdale Mavericks jumped out to a 41-0 halftime lead en route to a 48-0 shutout win over the Lynnwood Royals. The […]

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Oct 26 • 12:28 AM EDT • Sports • myedmondsnews.com
Asking Eric: Family bans ‘quirky’ friend from holidays

How does the letter writer tell a friend she's not welcome at family functions anymore?

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Oct 26 • 12:00 AM EDT • Technology • washingtonpost.com
Ewa Beach shooting survivor overcomes another health scare

Three years after surviving a gunshot to the head, Richianna DeGuzman is heading back to rehab following a week-long stay in the ICU.

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Oct 25 • 11:24 PM EDT • Health • hawaiinewsnow.com
😐 Neutral (0%)
Community members speak out during tense mental health advisory board meeting

Community members impacted by the withdrawal of Kings View services shared concerns during a mental health advisory board meeting last week, saying the closure of a local mental health center had left gaps in care. Board members also navigated a number of other tense moments during the meeting.

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Oct 25 • 11:20 PM EDT • Health • shastascout.org
Deep dive
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Can the Public Sector Offset Road-Construction Losses?

Hennepin Avenue was a cautionary tale.

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Oct 25 • 9:46 PM EDT • Business • tcbmag.com
Deep dive
😐 Neutral (7%)
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Politics Unplugged (Full Episode) Oct. 25, 2026

On this week's episode of Politics Unplugged, host Dennis Welch and a panel break down Arizona's election landscape one week out: pessimistic voter mood, suppressed independent turnout, lagging GOP enthusiasm, and Democrats gaining ground. They discuss Elon Musk's late spending in competitive House races and debate the impact of big money flooding the state. The show also covers a widely condemned Ohio attack ad by Vivek Ramaswamy that weaponizes a rival's childhood abuse—drawing praise from Trump and Vance but bipartisan outrage.

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Oct 25 • 8:31 PM EDT • Politics • azfamily.com
Edmonds Serves spotlight: Verdant Health Commission

The City of Edmonds is shining the spotlight on those recognized through Edmonds Serves, an initiative honoring all those who serve our community. This week it’s Deana Knutsen of the […]

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Oct 25 • 7:04 PM EDT • Health • myedmondsnews.com
Chiefs vs. Seahawks live updates, inactives, where to watch: Kenneth Walker III faces Seattle for first time since Super Bowl MVP run
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Oct 25 • 7:01 PM EDT • Sports • sports.yahoo.com
Sports equinox 2026: Date, schedule, meaning and history behind the rare event

The 33rd sports equinox will occur in 2026.

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Oct 25 • 6:57 PM EDT • Sports • sports.yahoo.com
West Louisville business transforms into soul food restaurant, arcade
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Oct 25 • 6:47 PM EDT • Business • whas11.com
Trump escalates rhetoric against El-Sayed as he tries to undermine Democrat in Michigan Senate race

The Republican president has been attacking El-Sayed's faith throughout the campaign and claiming his past statements and background show a sympathy for extremists.

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Oct 25 • 5:50 PM EDT • Politics • pbs.org
Serbia’s strongman leader Vucic concedes defeat to student-led movement in seismic political shift

It was a seismic political shift in the Balkan country where Vucic, who had been endorsed by Russian President Vladimir Putin and who denounced the student movement as a foreign-led attempt to unseat him, led with virtually absolute power for 14 years.

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Oct 25 • 5:35 PM EDT • Politics • pbs.org
Presidential race in Bulgaria heads to runoff due to record low turnout

In a surprisingly strong performance, the candidate of the pro-Western reformist opposition, Andrey Gyurov, will face the incumbent leftist president, Iliana Yotova, setting clear lines of division regarding the country’s future relationships with other nations.

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Oct 25 • 4:39 PM EDT • Politics • pbs.org
Mobile County Health Department updates sentinel chicken test

It concerned testing for St. Louis encephalitis

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Oct 25 • 4:30 PM EDT • Health • fox10tv.com
☹️ Negative (-11%)
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Kurt Warner Addresses Major Gaffe During Steelers Win vs. Saints

Kurt Warner knows Jaylen Warren’s name even better now. The former St. Louis Rams and Arizona Cardinals quarterback, who offered […]

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Oct 25 • 4:14 PM EDT • Sports • sports.yahoo.com
🙂 Positive (43%)
love
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Alaska Democratic Senate candidate Mary Peltola and her family suffer minor injuries in car crash

Peltola required medical attention after the accident, which happened when another vehicle crashed into the one transporting Peltola and her family, the campaign said.

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Oct 25 • 4:11 PM EDT • Politics • pbs.org
Is the Big 12 a two-bid CFP league? + 2-loss SEC playoff hopes + Lincoln Riley’s future at USC
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Oct 25 • 4:05 PM EDT • Sports • sports.yahoo.com
Kaine, Randall tour county's new Crisis Receiving and Stabilization Center

The Loudoun County Crisis Receiving and Stabilization Center's first day of operations on Oct. 22 included a tour by Sen. Tim Kaine, D-Va., and county Board of Supervisors Phyllis J.

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Oct 25 • 3:00 PM EDT • Health • loudountimes.com
How to watch the 2026 WNBA Finals: Golden State Valkyries vs. Atlanta Dream Game 5 time, schedule, where to stream and more
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Oct 25 • 2:46 PM EDT • Sports • sports.yahoo.com
😐 Neutral (13%)
Blanche says Trump isn't trying to meddle with Alaska election results by suing over Senate race

Blanche told CNN's “State of the Union” that President Donald Trump, who said Friday that he was "the one that said do it,” is not trying to overturn state election results “in any way, shape or form” on the cusp of the Nov. 3 election.

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Oct 25 • 2:19 PM EDT • Politics • pbs.org
Candidates differ on taxes, schools, health care

House hopefuls outline priorities ahead of election

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Oct 25 • 2:00 PM EDT • Health • sanduskyregister.com
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Oregon fires offensive coordinator Drew Mehringer after team scored just 10 points in loss to Illinois

Saturday's loss marked the third straight game in which Oregon scored under 20 points.

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Oct 25 • 12:57 PM EDT • Sports • sports.yahoo.com
Orlando Science Center hosts Halloween party

Adults can enjoy an open bar, laser shows, and more at the Orlando Science Center's Halloween After Dark on October 31.

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Oct 25 • 12:32 PM EDT • Science • wftv.com
Baylor reportedly fires head coach Dave Aranda, Joe Klanderman to serve as interim
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Oct 25 • 11:47 AM EDT • Sports • sports.yahoo.com
ESMO: Roche touts ‘convincing’ phase 3 KRAS data after win over rivals

Roche has shed more light on its investigational KRAS G12C inhibitor's phase 3 victory over Amgen’s Lumakras and Bristol Myers Squibb’s Krazati. The open-label Krascendo 1 trial enrolled 338 people with previously treated KRAS G12C-mutated non-small cell lung cancer (NSCLC). Patients who had already received a KRAS G12C inhibitor or pan-KRAS/RAS inhibitor were excluded from the trial. Participants received either divarasib once daily, Lumakras once daily or Krazati twice daily. Roche announced back in July that divarasib had demonstrated statistically significant improvements in progression-free survival (PFS) and overall survival (OS), meeting the trial’s primary and key secondary endpoints. But the Swiss pharma had been holding back the detailed data until now. At the European Society for Medical Oncology (ESMO) Congress in Madrid, Roche revealed that median OS for the 167 patients who received divarasib was 17.7 months, compared to 12 months for the 171 patients who received Lumakras or Krazati. The benefit was similarly clear when it came to median PFS, which stood at 9.8 months versus 5.7 months, respectively. A total of 44% of patients receiving divarasib were alive without disease progression at one year, compared to 24% of the control group, according to Roche’s presentation. It was a similar story for the objective response rate, which came in at 58% for divarasib versus 32% for the control group, while median duration of response was 11.9 months versus 6.9 months. Stefan Frings, M.D., Ph.D., deputy chief medical officer at Roche Pharma, told Fierce that the data made for a “very comprehensive, strong package, which should be convincing to health authorities.” “It’s an important advance for patients with lung cancer,” Frings said in an interview at a Madrid hotel during the conference. “It's a second-line setting, and patients who receive divarasib benefit compared to the current first-generation KRAS G12C inhibitors by having far longer overall survival,” he continued. “They live longer. They have better progression-free survival, better response rates, and with a safety profile which is—if [anything]—even better,” he said. According to Roche, 4.8% of patients receiving divarasib discontinued treatment due to treatment-related adverse events, compared to 11.7% in the control group. Serious treatment-related adverse events were also less common with divarasib, at 7.8% versus 15.2%. Roche’s confidence in divarasib had been building even before this phase 3 success. The candidate had already shown better potency and selectivity than the incumbent KRAS G12C inhibitors Krazati and Lumakras in preclinical tests. After cross-trial comparisons suggested that the edge translated into better clinical outcomes, Roche axed a study comparing divarasib to the chemotherapy docetaxel and went toe-to-toe with Lumakras and Krazati. “We designed the drug on purpose with higher potency and better selectivity,” Frings explained. “So, based on preclinical models, we clearly knew it would be superior to the first generation.” “It’s honestly not so frequent that pharma companies go head-to-head,” he added. “But if you want to make a point, if you want to convince payers, prescribers and patients … then a head-to-head win is rather rewarding.” While Amgen and BMS reached the regulatory finish line first for KRAS G12C-mutated, locally advanced or metastatic NSCLC in 2021 and 2022, respectively, they have struggled to capitalize on their head start. Krazati brought in $55 million for BMS in the second quarter, while Lumakras delivered $111 million to Amgen. For its part, Roche is aiming for peak divarasib sales of 1 billion to 2 billion Swiss francs ($1.2 billion to $2.5 billion), according to Frings. The Big Pharma is currently recruiting patients into a phase 3 trial comparing divarasib plus Keytruda against Keytruda plus chemotherapy in previously untreated advanced or metastatic nonsquamous KRAS G12C-mutated NSCLC. Roche has previously suggested that sales in metastatic disease would account for most of the forecast. Frings was tight-lipped on the exact timeline for a regulatory filing but said the Swiss pharma is “certainly keen to get this to as many patients as possible around the world.” Roche has more RAS drugs coming up behind divarasib. The pharma has already launched phase 1 trials of a pan-RAS inhibitor called RG6505 and a KRAS G12D inhibitor dubbed RG6620 in solid tumors. Roche’s partner Chugai Pharmaceutical is also testing a pan-KRAS inhibitor called AUBE00. Roche has made a “deliberate effort” to test a range of RAS drugs, Frings said. “If you have many rare mutations and you are scrambling to find sufficient patients, a pan-RAS inhibitor makes a lot of sense,” he explained.

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Oct 25 • 11:30 AM EDT • Health • fiercebiotech.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

During the hike, participants wore military short-shorts known as “silkies” as part of the event’s tradition to foster connection.

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Oct 25 • 11:27 AM EDT • Health • wpxi.com
Nonprofit organizes ‘silkies’ hike to support military members’ mental health

Veterans, active military service members and community supporters recently gathered for a hike organized by a nonprofit dedicated to suicide prevention.

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Oct 25 • 11:27 AM EDT • Health • wpxi.com
California election officials frustrated, rattled by DOJ demand to sequester 'noncitizen' ballots

The administration has insisted that immigrants voting is a major problem nationwide, when in fact it is quite rare, as even its own investigations have shown.

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Oct 25 • 11:17 AM EDT • Politics • pbs.org
Brazil votes in a tense Lula vs. Bolsonaro runoff with U.S. influence over Latin America at stake

The election pits the left-of-center veteran politician Lula against Bolsonaro, an ally of U.S. President Donald Trump and the son of imprisoned former President Jair Bolsonaro.

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Oct 25 • 10:57 AM EDT • Politics • pbs.org
Aaron Rodgers throws 540th career touchdown, passing Peyton Manning on all-time list

Aaron Rodgers now sits third all-time in passing touchdowns.

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Oct 25 • 10:49 AM EDT • Sports • sports.yahoo.com
Obama, in Midwest, assails 'cruelty' and indecency from Trump and his allies in the midterm campaign

Obama remains the Democratic Party’s best motivator nearly a decade after leaving the White House. And he's taking his star power on the road in the final days of the midterm elections, which will help determine the balance of power in American politics on Nov. 3.

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Oct 25 • 10:35 AM EDT • Politics • pbs.org
Peyton Manning reportedly has no interest in Colts' vacant GM position
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Oct 25 • 9:14 AM EDT • Sports • sports.yahoo.com
After win over Ole Miss, Texas QB Arch Manning says that he 'kind of likes being disregarded'
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Oct 25 • 8:41 AM EDT • Sports • sports.yahoo.com
Names in the News: People shaping the future of Lake Area business

The Sculptry promotes staff The Sculptry, Southwest Louisiana’s premier medical aesthetics clinic, has expanded its leadership team with the announcement of new positions for key staff members. Amber Pauley, RN, […]

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Oct 25 • 8:23 AM EDT • Business • americanpress.com
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U of M fellowship aims to boost rural obstetrics training and keep labor and delivery units open

The partnership is launching the new, one-year family medicine obstetrics fellowship next summer to prepare family medicine physicians to provide advanced prenatal, maternity and newborn care in rural communities. The only other fellowship of this kind in Minnesota is at Essentia Health in Duluth.

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Oct 25 • 8:00 AM EDT • Health • mprnews.org
Sunday Night Football: How to watch the Kansas City Chiefs vs. Seattle Seahawks game tonight
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Oct 25 • 7:15 AM EDT • Sports • sports.yahoo.com
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