SCROLL NEWS / DISCOVERY
Search headlines
Find the stories shaping the conversation.
Results for " rfa " 1,326 found 🔀 AI-powered Shuffle
Yale scientists may have found how Parkinson's disease spreads through the brain
Yale scientists discovered two neuron surface proteins that appear to help spread the toxic protein linked to Parkinson’s disease. Blocking these proteins in mice dramatically reduced disease progression, offering a potential new target for future therapies.
Why gold never tarnishes has finally been explained
Gold may have a secret self-defense system that helps it resist tarnishing. Researchers discovered that atoms on gold surfaces reorganize themselves into patterns that block oxygen from reacting with the metal, suppressing oxidation by up to a trillion-fold. Beyond explaining why gold jewelry stays bright for generations, the finding could help scientists create more powerful gold-based catalysts for manufacturing and clean energy.
Donkey Kong Arcade Set Surfaces In New LEGO Leak, Here's A First Look
It's on like Donkey Kong!
iOS 27: What's New With the Mail App
Apple's Mail app is getting some useful updates in iOS 27, with Apple making big improvements to search and introducing new AI features. Search iOS 27 has an overhauled search system that extends to the Mail app. Instead of surfacing results based on keywords and recency, Mail app search ranks results by relevance and intent. Search results that come up in Mail are more relevant than before, so you find exactly what you're looking for.
Mississippi mobile sports betting debate resurfaces amid lieutenant governor warning
Mississippi’s debate over mobile sports betting has resurfaced after Lt. Gov. Delbert Hosemann posted a warning on X urging the Senate to reject the measure.
Taylor Frankie Paul reportedly filming again on ‘The Secret Lives of Mormon Wives’
Embattled reality star Taylor Frankie Paul reportedly back in front of the cameras for ‘The Secret Lives of Mormon Wives,’ four months after video surfaced of her throwing a chair at her boyfriend Dakota Mortensen.
Bombing Iran, Then a Tentative Accord Didn’t Work. Does Trump Have a Plan C?
The administration appears to be reverting to an all-stick, no-carrot approach. But it has yet to answer why it believes economic warfare and bombing will yield a different result this time.
Tunable resonant metasurfaces enabled by atomically thin semiconductors
Light: Science & Applications - Voltage-tunable hybrid metasurfaces integrating 2D transition metal dichalcogenides with photonic bound states in the continuum enable dynamic control of...
NASA’s Dragonfly Clears Key Tests as Titan Rotorcraft Takes Shape
NASA’s Dragonfly is starting to look less like a collection of spacecraft parts and more like the rotorcraft that will fly across the surface of Titan,
Office Politics: Five Things Coworkers Say And What They Mean
Your coworkers are not saying what they mean. These five office politics phrases reveal what is really happening beneath the surface before it costs you your career.
Google Chrome 150 for Android adds dedicated back button
The latest version of Google Chrome is widely rolling out today with a dedicated back button and other small interface tweaks.
Plasma-state metasurfaces for ultra-intensive field manipulation
Light: Science & Applications - Plasma-state metasurfaces for ultra-intensive field manipulation
Intestinal muscularis in health and disease
Communications Biology - The authors review the intestinal muscularis – an increasingly recognized neuroimmune interface that orchestrates gut homeostasis, contributes to disease...
New Hanover County commissioners to vote on housing, business park, crematorium zoning
The New Hanover County Board of Commissioners will meet to vote on a $4 million workforce housing commitment, a construction contract for a new business park, and a zoning change for standalone crematoriums.
High-severity guest VM escape is 1 of 2 Linux vulnerabilities to surface this week
Both vulnerabilities allow untrusted users to gain root privileges.
Weibo leaker says iPhone 18 Pro thickness will be ‘surprising’
Days after materials from Apple supplier Tata surfaced online, prominent Weibo leaker “Fixed Focus Digital” doubled down on his earlier claim that the iPhone 18 Pro will be thicker than the iPhone 17 Pro.
The Politics of Provocation: The ECtHR’s Ruling in Miladze v Georgia
A recent judgment of the European Court of Human Rights concerning a TikTok video published by a Georgian self-defined civil activist adds another layer to the Court’s increasingly messy Article 10 case law. The applicant repeatedly insulted public officials in crude and sexually explicit terms while broadcasting to a large online audience. Domestic courts imposed only a modest administrative fine, later reduced on appeal. The ECtHR did not find a violation of the applicant’s right to freedom of expression – raising several questions about the limits of legitimate political speech online.
Why Democrats need Graham Platner to go away
A lot of people called for Graham Platner to drop out of Maine’s Senate race Monday night, after a rape allegation surfaced against the Democratic nominee. But relatively few of them were Republicans.
The sun's atmosphere is way hotter than its surface. Scientists may finally know why
NASA's Parker Solar Probe has found charged grains of dust being carried on magnetic plasma waves in the Sun's outer atmosphere, providing a new clue to the mystery of the Sun's corona is so hot.
Is there a Trump sports curse? USMNT's World Cup flameout revives the theory
From the Knicks' NBA Finals stumble to USMNT's Belgium blowout, a pattern keeps surfacing whenever the president shows up. Is it real?
Top Platner ally turns on him after bombshell rape allegation rocks campaign: 'Red line'
Rep. Ro Khanna withdrew his endorsement and called on Graham Platner to drop out after a sexual assault allegation surfaced against the Maine candidate.
Golden Knights sign last remaining RFA with NHL opportunity
While any business outside the organization is still up in the air, the Vegas Golden Knights have succeeded in getting all of their internal affairs in order.
Samsung ‘Galaxy Buds On’ surface with more Galaxy Watch 9, Ultra 2 leaks
Ahead of their launch, expected to be later this month, Samsung has accidentally confirmed its Galaxy Watch 9 and Ultra...
Jack’s Daily: Ducks Big Decision; Blackhawks RFA Tidbit; Robertson News
Back to business as usual following the 250th Birthday celebration for the United States of America this weekend. The Chicago […] The post Jack’s Daily: Ducks Big Decision; Blackhawks RFA Tidbit; Robertson News appeared first on Chicago Hockey Now.
Yana Rusovski Analyzes Fair Housing Compliance Challenges in Heartland Real Estate Business
Spencer Fane attorney Yana Rusovski authored the article What Housing Providers Need to Know About the IDHR Process, recently published by Heartland Real
Changing tides: How gravity warps our oceans - Futura-Sciences
Why gravity makes water uneven Water at any point in the ocean is pulled straight down, perpendicular to what physicists call an equipotential surface. Along this surface, the pull of gravity is identical everywhere. The specific equipotential surface that aligns with global sea level is known as the geoid. On...
Here's how much the Samsung Galaxy Z Fold8, Z Flip8 foldables will cost in South Korea
The foldables are expected to be announced later this month. Last week, the European pricing for Samsung's upcoming Galaxy Z foldables surfaced online....
Digital Science brings impact data into AI workflows
AI agents can now surface where research is being discussed, cited in policy, and mentioned beyond academic citations
As higher airfares and gas prices make vacations ‘crazy expensive,’ small business owners say Americans are staying closer to home this summer
“This summer, we’re still doing a couple overnights and the lake house, but nothing else.”
Scientists have now made the most comprehensive tally yet of deep-sea exploration — 43,681 dive records dating back to 1958 — and found that humans have directly seen less than 0.001% of the deep ocean floor, an area roughly the size of Rhode Island, leaving the vast seafloor across 66% of Earth’s surface essentially unobserved.
Humanity has sent cameras to the Moon, Mars, Venus and the outer planets, but on Earth itself there is still a larger frontier that has barely been looked at directly. A 2025 study in Science Advances has now put a number on that gap: since 1958, researchers have compiled 43,681 records of dives deep enough […]
Penguins Sign Ex-Capitals RFA Forward To Two-Year Contract
Steelers install new grass field at Acrisure Stadium after NFLPA survey graded previous surface poorly
The MacRumors Show: Latest iPhone 18 Pro Leaks and Rumors
On this week's episode of The MacRumors Show, we discuss the latest leaks and rumors surrounding the iPhone 18 Pro. Subscribe to The MacRumors Show YouTube channel for more videos Tata Electronics, one of Apple's manufacturing partners in India, was hit by a ransomware attack that resulted in more than 200,000 internal files being posted online, including component lists, supplier data, and images of iPhone 18 Pro test units.
Drug-resistant fungus Candida auris still on the rise in the U.S.
Candida auris can “colonize” the skin and spread easily to surfaces.
Valve releases Steam Machine e-ink faceplate CAD files and firmware
Build your own "inkterface".
Final Fantasy 7 Revelation store page lists multiple DLCs, including story expansion
Last month, we reported that Final Fantasy 7 Revelation, the final chapter of the acclaimed trilogy that is set to launch on Nintendo Switch 2 in 2027, could receive DLC after release. While the game is still a long way off, new evidence has surfaced suggesting that may indeed be the case. According to EpicDB, a third-party tool that tracks...
Intel Expected To Restart Supply Of 10th, 12th, 13th, And 14th Gen Processors In Mainland China
Intel will reportedly focus more on the previous-gen processors to fulfill the current demand in the PC market. Intel is Reportedly Restarting Supply of Last Four Generation of Processors as Motherboard Vendors Ramp Up DDR4 Platform Production Roughly a month ago, we reported that some vendors are now restarting the production of DDR4 platforms, i.e., DDR4-compatible motherboards. This is to ensure the market gets DDR4 motherboards in sufficient quantity, as expensive DDR5 memory has made it unfeasible to build DDR5 systems on a budget. More reports are surfacing confirming the same report, and Intel appears to have prepared accordingly. Related […]
Applications Opened July 1 for Wyoming's Rural Health Transformation Funding
CHEYENNE, WY – Today, the Wyoming Department of Health (WDH) announced the opening of Requests for Applications (RFAs) for Wyoming’s Rural Health Transformation Program, a major initiative designed to strengthen healthcare access, improve health outcomes, and support innovative solutions for rural communities across the state. The funding opportunity represents an important step in implementing […]
Global ocean temperatures are entering “uncharted territory,” climate scientists say
Sea surface temperatures in late June reached nearly 70 degrees Fahrenheit on average, shattering records
Trump made $1.2B through crypto in 2025. Jonathan Swan says that likely doesn’t ‘scratch the surface’ of the family’s gains
Rumor: Metroid Ravenous leaked for Nintendo Switch 2
Metroid Ravenous has apparently been leaked for Nintendo Switch 2. A listing for the game supposedly surfaced within Brazil’s Ministry of Justice and Public Security system. The page has already been removed, but not before a screenshot was taken. Here’s a snapshot of the classification: The listing doesn’t provide any specific details about the game. However, the classification indicates 2026...
PlayStation Plus July 2026 free games lineup announced, including Modern Warfare 3
Play a recent Call of Duty for free before Modern Warfare 4 drops this fall
July’s three PlayStation Plus ‘free’ Essential monthly games include Call of Duty Modern Warfare 3
There are three games available for subscribers to claim this month…
There's a Waterfall in Antarctica That Bleeds Red – Here's What's Hiding Inside It
Antarctica's Blood Falls are even weirder than they look.
Google's chatty Keep Live and Gmail Live interfaces make first appearance
Google's 'Live' conversational AI is now showing up in Keep and Gmail, letting you chat with your notes and emails directly.
Blackhawks Extend Qualifying Offers To Bedard & Three Other RFAs
Ahead of Monday’s 4:00 p.m. (CT) deadline, the Chicago Blackhawks issued qualifying offers to four of their six pending restricted […] The post Blackhawks Extend Qualifying Offers To Bedard & Three Other RFAs appeared first on Chicago Hockey Now.
Call Of Duty: Modern Warfare 4 Pre-Order Ad Reminds Everyone It's 'Not On Xbox Game Pass This Year'
The messaging mess is in full swing
Google Pixel Watch 5 seemingly surfaces with four variants and even more questions
As another year goes by since the last Pixel hardware launch, the Pixel Watch 5 is beginning to surface online...
Alleged Modern Warfare 4 ad uses ‘not on Xbox Game Pass’ as a selling point
This year’s Call of Duty will be the first to skip Game Pass since 2023…
Apple Acquires Award-Winning App 'Play'
In February, Apple notified the European Commission that it would be acquiring certain assets from and have the right to hire certain employees from Rabbit 3 Times, the company behind the award-winning app design tool Play. The notification was published on the European Commission's website this week, following a four-month waiting period. Play was a Mac and iPhone app that allowed designers to prototype iPhone app interfaces using Apple's SwiftUI frameworks, and then send them to Xcode.
Sharks Sign Kesselring, How To Unlock His Potential?
The San Jose Sharks have signed Michael Kesselring. The Sharks signed the 26-year-old defenseman to a three-year, $13.5 million contract ($4.5 million AAV), buying up two of his UFA seasons. There were no trade protections. Kesselring was a pending RFA. The #SJSharks signed recently acquired 26 y/o RFA RD Michael Kesselring to 3 year $4.5M […] The post Sharks Sign Kesselring, How To Unlock His Potential? appeared first on San Jose Hockey Now.
Concerns with the Sebastian County Sheriff’s office
The recently-surfaced video showing the potential maltreatment of a Sebastian County Jail inmate, and a subsequent statement about the troubling incident from interim Sheriff Mike Conger point to the need...
Galaxy Z's days are apparently numbered: Accessories point to a very unusual name for Samsung's iPhone Ultra competitor
At first, it was called the Galaxy Z Wide Fold or the Galaxy Z Fold 8 Wide, then—according to generally reliable sources—simply the Galaxy Z Fold8. Now a fourth name has surfaced for the compact and wider iPhone Ultra alternative, that Samsung will unveil on July 22 alongside the updated Galaxy Z Fold 8 Ultra. However, as authentic as these images seem to be, there are doubts.
EXCLUSIVE: Three Candidates Vying For Global Fund Leadership In Contentious Race
As the Global Fund heads into a secretive but highly contentious election of its new Executive Director, the names of three likely US candidates have surfaced - former Global Fund Executive Director Mark Dybul, former Trump appointee William Steiger and a former NYC public health official, Ashwin Vasan.
Los Alamos Faith And Science Forum Announces Schedule Of Lectures Through Aug. 12
Courtesy image/LAFSF Los Alamos Faith and Science Forum News: For 2026, the Los Alamos Faith and Science Forum invites the public to examine issues at the interface of faith and science on Wednesdays through Aug. 12. After a light dinner at 6 p.m., presentations will begin at 6:30 p.m. to be followed by a Q […]
Brain activity under anesthesia challenges what we know about consciousness
The unconscious brain appears to be far more capable than scientists once believed. Researchers found that patients under general anesthesia could still process language at a sophisticated level, distinguishing nouns, verbs, and adjectives while listening to stories. Even more remarkably, neural activity showed signs of predicting upcoming words before they were heard. The results challenge traditional ideas about consciousness and hint at new possibilities for brain-computer interfaces.
Yellowstone’s supervolcano may be fueled by something unexpected
Scientists have uncovered a new explanation for what powers Yellowstone and other supervolcanoes. Instead of a deep plume rising from near Earth’s core, a broad “mantle wind” may push hot rock beneath Yellowstone, generating magma closer to the surface. This process helps create a massive underground magma network and may explain how supervolcanoes remain active for long periods.
Apple A20 Pro motherboard leak hints at notable memory and packaging upgrades
A leaked package layout of Apple's A20 Pro hints at several notable upgrades for the iPhone 18 Pro series. The next-gen SoC is said to feature a wider 96-bit memory interface, a redesigned packaging approach for improved thermals, and a larger Neural Processing Unit (NPU).
MAI-Code-1-Flash for Copilot Business and Copilot Enterprise
MAI-Code-1-Flash, Microsoft AI’s in-house coding model, is now generally available for GitHub Copilot Business and Copilot Enterprise, building on its recent expansion across Copilot surfaces. Purpose-built for coding and optimized…
How to get free Windows 10 security patches until October 2027 - and avoid the $30 fee
Don't want to pay to keep Windows 10 security updates? Microsoft has several workarounds, with the best deal for European users.
Scientists stunned by signs of ancient life in a place no one expected
Scientists exploring ancient seafloor rocks in Morocco discovered mysterious wrinkle patterns where they were never expected to occur. These structures are normally linked to microbial mats in shallow, sunlit waters, yet the rocks formed hundreds of feet below the surface in darkness. Evidence indicates that chemosynthetic microbes created the wrinkles, revealing that deep-ocean microbial ecosystems may have been more widespread than previously thought.
Scientists find evidence of vast hidden magma systems inside Mars
Researchers from the University of Oxford have uncovered evidence that Mars once hosted enormous, Earth-like magmatic systems deep beneath its surface—despite the planet lacking the plate tectonics long ...
EVA HENRY: Corruption resurfaces in Adams, Arapahoe County politics linked to One Main Street
Corporate dark money groups are funneling millions into eleven different races statewide.
Video of Tom Sandoval pushing ex's dad into firepit surfaces
Bravo alum Tom Sandoval is in the midst of another controversy after video surfaced showing an altercation with his ex and her father.
Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
Athlon Sports picks Bengals to resurface an old, heartbreaking trend
Would this be enough for Zac Taylor to get another season as the Bengals head coach?
Athlon Sports picks Bengals to resurface an old, heartbreaking trend
Would this be enough for Zac Taylor to get another season as the Bengals head coach?
Microsoft introduces cheaper Surface devices with half the memory
The 12-inch Surface Pro now starts at $849, while the 13-inch Surface Laptop costs $949 and up. Both start with 8GB of RAM instead of 16GB.
Celtics' star Jaylen Brown's future remains murky
His name surfaced in trade talks for Giannis Antetokounmpo, who was ultimately traded to the Miami Heat. Boston's offer, including Brown and draft picks, wasn't enough to top Miami's.
Microsoft relaunches 2025 Surface Pro and Laptop with half the memory, but at higher prices than original 16GB models
Microsoft is now selling cheaper Surface Pro 12-inch and Surface Laptop 13-inch configurations with 8GB of RAM.
Monster Fantasy Combines the Thrill of Monster Hunter with the Cosy Chill of Animal Crossing
We got hands-on with a very early build of Monster Fantasy, a hybrid adventure that gives players the flexibility to choose whether they want to seek the thrilling challenge of big game beast-hunting or the laid back chilling of just catching bugs and good vibes with their fellow villagers.
Microsoft releases smaller Surface Pro with cheaper price and 90 Hz display
Microsoft has released a new Surface Pro 2-in-1. Smaller than the new Surface Pro 12 that features a 13-inch display, the updated Surface Pro 12-inch features a 90 Hz display and a Snapdragon X Plus chipset, but only 8 GB of RAM.
Microsoft releases new 13-inch laptop globally with cheaper starting price
Microsoft has released a new version of its Surface Laptop 13-inch. Sold globally, the updated Surface Laptop 13-inch is much cheaper than Microsoft's existing models. Sadly, the device achieves a $200 saving by returning to 8 GB of RAM.
Meet Caramelo, the Mexico superfan attending his 11th World Cup
Long after Mexico’s World Cup win against South Korea, fans young and old lined up outside the stadium to take photos with Héctor Chávez and his big black sombrero. Also known as Caramelo, candy in English, Chávez is arguably as well-known in Mexico as the members of the national team. Now at his 11the World Cup, Chávez is flanked by his 21-year-old son, also called Héctor Chávez, and known as Caramelo Jr. Both wear oversized sombreros with their nicknames written in all caps, making them hard to miss at stadiums.
Build an AI Scientist for Life Science Discovery with NVIDIA BioNeMo Agent Toolkit
AI scientists are emerging as a new interface for scientific computing. These agents can read papers, write code, generate hypotheses, call APIs, inspect files, and iterate on results. But science isn’…
Scientists Finally Find Out Why Gold Never Rusts Like Other Metals
Gold’s pristine shine may depend on an until now hidden atomic rearrangement at its surface.
Should the Yankees deploy a six-man rotation?
Do the Yankees have the pieces and the need to pull off a long-debated roster strategy?
Earth’s mantle may be hiding an ocean’s worth of water 410 miles down - Futura-Sciences
An estimated 4.4 billion years ago, a series of planetary collisions delivered the vast majority of Earth’s water budget to a world whose surface was still a bubbling, glowing ocean of molten rock. As this global magma ocean slowly cooled and crystallized over millions of years into the planet’s first...
Road resurfacing to begin on Business Route 50 near California on Monday
One lane of Business Route 50 will be closed from 6 a.m. to 6 p.m. Monday through Friday, until the end of July.
A Big Change Is Coming to Roku TVs
A big transformations are underway across the Roku TVs home screen as leading manufacturers, including TCL, begin implementing standardized home screen interfaces on their devices. This shift replaces the previous customized designs that each brand had developed independently with the uniform Roku platform experience. The result is a more consistent visual presentation that emphasizes the […]
Pai family patriarch celebrates generations involved in surf shop business, Surf City community
Aaron Pai bought Huntington Surf and Sport nearly 50 years ago, and has created a legacy of “aloha” with his own growing family, and the surfing “ohana” across Huntington Beach and the world.
A $75,000 Problem in My Business Taught Me the One Leadership Skill That Matters Most
Great leaders demonstrate strong judgment by surfacing problems early, preserving options, and enabling teams to act before it’s too late.
How to Switch To The New Roku Home Screen on Roku TVs & Roku Players
Roku has introduced a way for owners of its streaming devices and televisions to switch to the company’s newly redesigned home screen ahead of the automatic rollout. The new interface represents the most significant overhaul to the platform’s main screen in more than a decade, bringing enhanced personalization, quicker content discovery, and a more dynamic […]
World Cup brings political issues to the surface: 5 takeaways
The first week of the FIFA World Cup has been underscored by tensions over geopolitics, U.S. immigration policy and dramatic group stage action that is priming viewers around the world for what pro…
Republican U.S. Senate Candidate visits Marquette County west end business
Republican Candidate Mike Rogers visited Robbins Sports Surfaces in Ishpeming Friday afternoon
Wealth management firm is the latest to announce a new Towne Center location
Merrill Lynch Wealth Management, a Bank of America company, plans to open a new location in Towne Center. Media reports surfaced early Friday that Bank of America would open its first Louisiana bra… Already an INSIDER? Sign in. Already an INSIDER? Sign in
A brain-computer interface has, for the first time, restored fluent everyday speech to a person who had lost it — a man with ALS who had not spoken aloud in years until a small implant from the BrainGate clinical trial began translating his attempts to speak directly into computer-synthesised words, in a result researchers reported in June 2026
Casey Harrell can now talk for twelve hours at a stretch. Two years ago, he could not talk at all. The ALS he was diagnosed with several years earlier had progressively destroyed the motor neurons controlling the muscles of his face and throat, leaving him with the symptoms doctors call dysarthria and, eventually, anarthria — […]
Watching water nanodrops spread themselves thin
Researchers at the Institute of Industrial Science, The University of Tokyo, have determined the molecular origin of line tension for a water nanodroplet on a surface. This tension is the force along the droplet edge where liquid, solid, and gas phases meet. Computational studies showed that at complete wetting, collapse of tetrahedral order in liquid water causes the line tension to change sign. An ice bilayer did not wet a hydrophilic surface, showing that local order can outweigh surface chemistry.
Philips Hue Adds Play Table Lamp, Floor Lamp, and New Candle Bulbs
Signify today announced two new Philips Hue devices to expand its Hue Entertainment lineup, debuting the Philips Hue Play Table Lamp and the Philips Hue Play Floor Lamp Large. There are also new candle bulbs. The two lamps are similar to the existing Signe Hue table and floor lamps, featuring a tall, linear design that casts light on a wall or surface behind the light.
Dem Senate hopeful under fire for resurfaced comments calling cops 'opportunistic cowards'
Graham Platner's anti-law enforcement Reddit posts resurfaced as the far-left populist seeks to unseat Sen. Susan Collins in Maine's Senate race.
GTA 6 Gameplay Leak Surfaces Ahead Of Trailer 3
Grand Theft Auto VI is closer to release than ever before, and the leaks continue to appear ahead of its arrival.
El Niño Is Underway
Satellite observations of sea surface height indicated that the 2026 event continued to strengthen in early June.
ALS Patient, 47, Gains Ability to Speak and Sustain Full-Time Job Using Experimental Brain-Computer Interface
FSU scientists uncover differences in drivers of long-term temperature changes in Atlantic, Pacific oceans
Florida State University researchers have identified key differences in the root causes of long-term sea-surface temperature changes across the Atlantic
“This has never been seen before”: the mind-blowing discovery made by this deep-sea squid - Futura-Sciences
A Scene Never Seen The moment was caught by researchers using a remotely operated underwater vehicle (ROV) at approximately 13,450 feet (that’s about 4,100 meters) below the surface, in the Clarion-Clipperton Zone (CCZ) – a vast abyssal plain in the Pacific, now at the center of deep-sea mining ambitions. The...
2026 World Cup billed as ‘largest entertainment attack surface in history’
As the tournament is underway across North America, Palo Alto Networks warns that temporary supplier ecosystems, vulnerable municipal infrastructure, and geopolitical tensions are creating risks fo...
Superconductivity breakthrough could unlock ultra-efficient electronics
A clever nanoscale redesign may have solved one of superconductivity’s biggest problems. Researchers in Sweden discovered that by subtly sculpting the surface beneath an ultrathin superconducting material, they could make it stay superconducting at higher temperatures and under much stronger magnetic fields.
AI and brain-computer interface allow speechless ALS patient to work a full-time job
The hardware isn't new, but a UC Davis research team's machine learning-powered method of translating brain activity in an ALS patient into sentences with 92% accuracy is
Arman Tsarukyan urges UFC to cut former title challenger
Arman Tsarukyan is urging the UFC not to allow one of its former title challengers to step into the octagon again. As the dust settles on a historic night at the White House, several key talking points have surfaced. Most are directed toward fighters at the top of the bill, with questions being ...