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Scientists Studying Earth's Flowering Plants Issue a Stark Warning to Humanity
Here's just how much we stand to lose.
Scientists Studying Earth's Flowering Plants Issue a Stark Warning to Humanity
Here's just how much we stand to lose.
Vikings Receive Stern Warning on Depth Chart Battle
Splitting practice reps risks stalling Kyler Murray’s transition to Kevin O’Connell’s system, giving J.J. McCarthy a tactical edge despite last season's struggles and glaring accuracy concerns.
Why the Trump effect is different in 2026 than 2018
The brightest warning light for Democrats in this year’s election is the consistent finding in early national and state polls that they are not winning nearly as large a share of voters who disapprove of President Donald Trump’s performance as they did during his first term. Paradoxically, that dynamic could represent a major danger for Republicans if it proves unsustainable through November.
Domestic violence groups fear survivor services could disappear without warning
A new rule change would allow agencies to terminate federal grants for political reasons — without a reason or appeal.
Inside Iowa Politics: Warning from U.S. House Speaker Mike Johnson to Iowans
U.S. House Speaker Mike Johnson had a warning for Iowans when he addressed the Family Leadership Summit.
Inside Iowa Politics: Warning from U.S. House Speaker Mike Johnson to Iowans
U.S. House Speaker Mike Johnson had a warning for Iowans when he addressed the Family Leadership Summit.
Yankees Face Trade Deadline Warning After Dire Aaron Judge News
The New York Yankees will need to take an aggressive approach to the trade deadline with Aaron Judge out, an insider suggests. The post Yankees Face Trade Deadline Warning After Dire Aaron Judge News appeared first on HEAVY.
Colorado health officials are tracking toxic algae blooms with warnings of health impacts
Not all blooms produce toxins, but with warm temperatures and shallow reservoirs, conditions are primed for algae to grow explosively.
Wildfire Smoke Prompts Health Warnings
WASHINGTON — Scorching temperatures are contributing to wildfires that are erupting faster than usual this year in the United States and Canada while also prompting health warnings about air pollution. In the United States, some of the worst wildfires are burning this week in Colorado, California, Minnesota and other parts of the Upper Midwest. They … Continue reading "Wildfire Smoke Prompts Health Warnings"
Kraken CEO warns that Washington state business leaders are eyeing exits
Tod Leiweke, CEO of the Kraken NHL team and one of the key figures pushing to return the SuperSonics NBA franchise to Seattle, dished some economic words of warning for state lawmakers on Thursday.
The Odyssey Fans Say The Movie Needs An Epilepsy Warning
Christopher Nolan’s latest film has one segment that fans are warning new viewers about
State warns of new "Mr. Finance" investment solicitations from man accused of running Ponzi scheme
The Illinois Secretary of State is warning a businessman known as Mr. Finance, already accused of running a Ponzi scheme, may be soliciting investments in an allegedly sketchy new business.
Illinois takes action against new business promoted by Chicago businessman 'Brandon Mr. Finance'
The Illinois secretary of state is warning consumers about a new business being promoted by "Brandon Mr. Finance," and has issued a cease-and-desist order against the venture.
Raccoon in Whitesboro tests positive for rabies, health officials warn
A raccoon in Whitesboro has tested positive for rabies, and county health officials say it's a good reminder to know the warning signs of rabies.
Smoke from Canadian wildfires prompts more health warnings in New Hampshire
Wildfire smoke blowing in from Canada has cast a yellowish haze across skies in New Hampshire and prompted warnings from health officials.
Why JPMorgan is 'the only business' that can 'weather any downturns'
JPMorgan (JPM), Citigroup (C), Bank of America (BAC), Goldman Sachs (GS), and Wells Fargo (WFC) all reported second quarter earnings results on Tuesday. Whalen Global Advisors chairman, Chris Whalen, shares his take on JPMorgan's record results and CEO Jamie Dimon's recent warning.
Trump revives his decades-old Iran warning as US ramps up military pressure: 'remarkably consistent'
A 1980 video clip shows Trump urging the U.S. to send troops into Iran during the hostage crisis, resurfacing as CENTCOM resumes a naval blockade.
47 revelatory hours with Assassin’s Creed Black Flag Resynced
To review this month’s supposed remake of 2013’s Assassin’s Creed IV: Black Flag, I must first correct the record. Assassin’s Creed Black Flag Resynced isn’t a game about pirates (and assassins) in the 18th century Caribbean. Sure, sure, that’s what the trailers would have you believe. They’ve go their clips of Edward Kenway swinging his swords and steering his pirate ship into cannon-blasting combat against British frigates. Is Resynced truly a pirate game? Of the 47 hours I spent playing Resynced over the past few weeks, I will admit I spent maybe 44 (?) of them collecting plunder with Blackbeard, drinking rum with Anne Bonny and debating the pros and cons of the lawless pirate-run settlement Nassau with Benjamin Hornigold. I may in fact have spent dozens of hours sailing to remote islands, reading treasure maps, opening messages left in bottles, sinking the odd Man o’ War with a well-timed broadside, collecting sea shanties for my crew, befriending a pet monkey, and hunting whales. I am nevertheless neither so Gullible nor so Narrow-Minded as to call the magnificent Resynced a “pirate remake.” Oh no. Forget any reviews of Assassin’s Creed Black Flag Resynced you may have read. Forget what you yourself may have played, if you’ve spent any time with the game since its launch. What Assassin’s Creed Black Flag Resynced is really about I’m here to give you the scoop (spoilers for Resynced’s Animus menu lore, which many players are probably not going to see): Assassin’s Creed Black Flag Resynced, the new game whose development was led by Ubisoft Singapore, is set in the year 2096. It’s about a societal split, about revolution, about an old Assassin’s Creed adventure repurposed in the series’ distant future as propaganda or samizdat. It’s about the overheated future of 2096, essentially conquered by the series’ well-established nefarious Templar-run company Abstergo. (In this future, Abstergo is, among other things, remaking a 2013 pirate movie called Devils of the Caribbean, but this time in VR. The VR version will be backed by a marketing plan that involves AI influencers, a 10,000-avatar “metaverse premiere event” and that manufacturing of memes aimed at “50 million VR nodes.” See what I mean about Abstergo being evil?) Resynced is about a late 21st-century population mollified by the widespread use of Abstergo’s Animus devices which let people experience the lives of historical figures culled from “genetic memories.” It’s about an insurgent faction of Assassins. And it’s about a plan to wake the population into revolutionary fervor by showing them the memories of 18th century pirate Edward Kenway, who—as depicted in the original Black Flag and again in Resynced—gradually comes to an understanding about the Assassins of his day and their centuries old fight for freedom. Resynced is also about an AI developed within the late 21st-century Animus, called Ego. It has found a way to alter genetic memories, to create and show Animus users false ones. The game is about Ego’s efforts to tell the people experiencing Edward Kenway’s memories that Kenway was wrong, that fighting against order is folly, that we should crave a world where “compliance is rewarded with power.” Who are we in this game? We’re an unnamed Animus user in 2096 who experiences Kenway’s journey virtually. At four moments during Kenway’s exploits in the Caribbean our virtual jaunt can be interrupted for 10-15 minutes, as we explore Animus “rifts” where Ego explicitly tries to tell us how wrong Kenway was. None of this is what 2013’s Assassin’s Creed IV: Black Flag was about, of course. That was a different game, even if you also spent dozens of hours pirating as Kenway in that game, across missions and a map that’s been faithfully reintroduced and rebuilt for Resynced. The 2013 Black Flag was about you playing as an unnamed researcher newly hired in 2013 by Abstergo Entertainment, the video game development wing of the Templars’ evil-corp. In that game, you were assigned to use the Animus to dive into the genetic memories of Desmond Miles, a man who died in Assassin’s Creed III and who was descended from a long line of Assassins (and at least one Templar) whose adventures were featured across the prior AC games. In 2013’s Black Flag, your mission was to plumb the Edward Kenway experience for material that Abstergo could use in productions such as the motion picture Devils of the Caribbean, though the Templars had some ulterior motives for the assignment. Resynced is therefore not a remake of 2013’s Black Flag. It’s a sequel. It is a new game about a new exploration of Edward Kenway’s pirate/assassin journey, set 83 years after the framing sequences of the original game. Resynced provides a new narrative framework that, thanks to the concept of an AI that wants to alter historical memories, arrives with creative justification to tweak a now-classic 13-year old game. That makes Resynced, already a hot seller, a tantalizing hint of where Ubisoft could go with a line of Assassin’s Creed remakes. They could remake the first game, the Ezio games, even the recent ones set in ancient Egypt and Greece. And for each, they could not just modernize the graphics and controls but expand and alter their sequences of events to use them as reference points for a conflict set in the late 21st century, as rival factions try to weaponize historical memories. Game File is a reader-supported publication. To receive new posts and support my work, even when that work consists of ravings about Assassin’s Creed’s modern day plot, please consider becoming a free or paid subscriber. Subscribe A story most players will probably miss If you didn’t know any of this, I’m not surprised. If you played the game and still didn’t catch it, I’m not a bit shocked. If Ubisoft has no plans to do more of this, I won’t fall down. Almost all of what I’ve described is optional and missable in Black Flag Resynced. I nearly missed it myself, as I planned for a breezy playthrough of an old Assassin’s Creed favorite. Instead, I found myself in a 40+ hour hunt for the “real” story, buried deeper in Resynced than any gold-filled chest. The story of 2096 is Resynced’s meta-story, told in two remote pockets of the game: 1) four optional playable “rifts” that players may find as they proceed through Resynced’s pirate fantasy , 2) in dozens of text files tucked three menus deep in the game’s barely-interactive Animus hub. Assassin’s Creed games have almost always had a meta-story about people in the 21st century (usually matching the game’s release year) and their connections to the main history portions you play. Those meta-stories have always been squeezed into the margins, though seldom as severely and as, uh, graphiaclly simple, as in recent games. Back in 2013, the modern-day exploits of you as an Abstergo Entertainment employee were prominent. They were portrayed via first-person portions that occasionally interrupted the third-person Kenway experience and could be explored for hours, complete with their own missions, side quests and puzzles. Resynced’s 2096 story—of Assassin “Watchers” vs. Abstergo/Tempar goons, of rogue AIs, of panicking scientists, of a woman wondering why her Animus-addicted husband is muttering about Mary Read (“What does he mean by Assassins?”), of a fight for the population’s hearts and minds via varying interpretations of Edward Kenway’s life choices—is mostly told through unlockable text files. The files are interesting. Offered via diary entries, intercepted chats and news reports, they present varied perspectives of a world in crisis. One set works as a narrative puzzle as it reveals the Rashomonic interpretations of a massacre, or was that a successful Assassin hit? Another favorite reveals the rising bitterness of a person who, through Edward Kenway’s journey, now shakes at the ignored evil around him. One surmises that Ubisoft is averse to putting the Assassin’s Creed’s meta-story in the way of more marketable pirate playgrounds and ninja/samurai epics. Instead, we get a better-than-nothing text-in-menus approach introduced in 2025’s Assassin’s Creed Shadows. In Shadows, players unlocked the meta-story text files largely via time-gated missions that called on the user to kill X number of enemy type Y, clear three enemy castles, re-win a three-phase fighting tournament, and other grinds. Time restrictions on accessing these missions and unlocking the files meant it could take players months to access the full story in-game. But even in the most hardcore Assassin’s Creed hangouts, the fanbase instead seemed to throw up their hands rather than grind to keep up. In Resynced, Ubisoft has shown some mercy, diminishing the amount of new text files that are tied to timed grinds. Now, most of the text-based 2096 lore are associated with “data file” collectibles that players can find in the world. That includes a batch of written entries that explain a historical link between the feudal Japan era in Shadows and the piracy adventures in Black Flag. Players who explore a lot will find dozens of data files, though the game does not appear to offer any in-game tracker for finding each one. You just need to keep looking for them. As of this writing, I have most of them, but not all. I can’t find any full guide for them online. And even Ubisoft’s optional $5 microtransaction that reveals lots of items in-game does not appear to reveal the locations of the text files (at least the official description omits them from its collectibles list). That’s not a huge bother, because tracking the data files down compelled me to re-explore the waves and islands of Black Flag. That was a thoroughly pleasant task to do for the first time in a dozen years. I expect many players, though, will be content to wait for the files to be reproduced in an online AC wiki somewhere, the easier to read on a web page. It may not seem enticing to play a video game in order to gradually unlock pages of text to read. Why not, you may ask, just read a book, where they put the pages in order? For one, they’ve not tucked this latest installment of Assassin’s Creed’s meta saga in a book. I also enjoy the unordered delivery, the dawning comprehension of a story about 2096’s desperate people and questionable tech, which I glimpsed first at its middle, then the end, then the front, then other moments in between1. I am also enamored with the idea of the Assassin’s Creed games I’ve previously played, including Black Flag, being repurposed for an information war. The ideas in Resynced’s meta-story, which builds off characters and ideas in Shadows’ chunks of text, are strong. The potential of where they could go with it is exciting. As for the pirate stuff? Looks great, controls pretty well, is fun to play and oh so speedy in terms of how much of a good time you can have with each sit-down. It never gets old to chase a new shanty page across a rooftop, bombard a fort with upgraded mortars or use a diving bell to explore sunken wrecks (hats off to the team at Ubisoft Barcelona that worked on the underwater portions in Resynced; that team is now facing layoffs, such is the misery of modern gaming and oft-troubled Ubisoft). New pirate missions in Resynced involving new ally characters are brief, dramatic and add more to Edward’s story, even if the gameplay perks they provide barely enhance the gameplay. A new denouement for high-class pirate Stede Bonnet is affecting; a new hunt for Blackbeard’s treasure is a welcome extra moment. A new epilogue to hunt down a pirate killer, on the other hand, over-complicates Kenway’s character. The ending credits remain my favorite of any game I’ve ever played. Black Flag provides great source material. The revisit is well-made and a great sign of what could be. It is offered in a different wrapper that hints at an opportunity for more interesting remakes to come, should Ubisoft choose to pursue such treasures—and as we brace to resist or comply with an Abstergo future. 1 The messages that Edward Kenway finds in bottles tell another out-of-order story, one about a man reckoning with the strange memories and voices he’s heard in his head since he was a boy. That tale was also in the 2013 game and develops into one of Black Flag’s most compelling character arcs. In Resynced, it has lost its climax, because the bottle story previously paid off in the halls of the first-person Abstergo Entertainment, which is exclusive to the older game. An altered resolution, written by the 2013 game’s lead writer is fine, doesn’t invalidate the 2013 version, but makes for an inferior final note.
Measles exposure warning issued for three Providence Health sites in Portland metro
Oregon health officials identified three potential measles exposure sites at Portland-area Providence facilities.
Smart people: IBM's AI warning sparks new Saaspocalypse fears
IBM CEO Arvind Krishna wrote a letter to shareholders about a revenue miss. It's renewing months-old fears about a SaaSpocalypse.
New Legislation in Hawaii Strengthens Public Health Reporting
On July 9, Hawaii Governor Josh Green (D) signed Act 222, legislation to ensure the continuation of the state’s syndromic surveillance program, which serves as a critical early warning system for emerging health threats.
Google DeepMind CEO issues stark warning about AGI
Google DeepMind's Demis Hassabis advocated for a US-led coalition to govern AI development, highlighting AGI's impending global impact.
iOS 26.6 Will Warn You About Malicious iMessages
Apple is adding a new warning about malicious iMessages in iOS 26.6, according to X user @limpless_skelly, who shared a mockup of the notification. The pop-up will warn users that a message could be trying to harm their iPhone or compromise their privacy. Apple asks users to share the message so it can guard against future attacks, and there are "Not Now," "Share With Apple," and "Don't Report" options to tap.
Satya Nadella has issued a shocking warning to companies using AI
In a surprising blog post on Monday, Microsoft CEO is warning enterprises of the dangers of using proprietary models like Anthropic's and OpenAI's.
What You Need to Know About Aortic Tears and Bone Health
Dr. Ian Smith, physician and other of “The Last 15: Say Goodbye to Those Most Stubborn Pounds,” joins TODAY to share the warning signs of an aortic tear and breaks down how to improve your bone health.
Maine Democrats to Chuck Schumer: Stay Out of Our Senate Race
Local Democrats are warning the top Senate Democrat to keep away as they replace Graham Platner, and the candidates are giving his leadership in Washington low marks.
Heart condition tied to Lindsey Graham's death can strike without warning
Preliminary findings suggest aortic dissection was the cause of Sen. Lindsey Graham's sudden death. Doctors explain the warning signs and high-risk groups.
State legislators warn of threat to film and TV tax credit program
More than three dozen state legislators have sent a letter to Gov. Gavin Newsom and state government leaders warning of a threat to the film and TV tax credit program.
A hotter Europe needs Israeli science
The recent heat dome that swept across the continent pushed temperatures to record levels, strained electricity grids, disrupted transport, and forced governments to issue public health warnings.
Venezuela's devastating 'earthquake doublet' holds a warning for California's San Andreas Fault
The Venezuelan earthquake doublet is a stark reminder that multi-fault systems may pose greater destructive power than some seismic models predict.
Trump rips Haberman, says she’ll ‘pay the price’ over health reporting
President Trump slammed New York Times journalist Maggie Haberman after she questioned his physical and cognitive fitness during an appearance on MS Now, warning that she will “pay the price” when …
Health officials warn of measles exposure at 7 Nashville businesses over July 4 weekend
Nashville health officials are warning residents who visited seven businesses between July 1 and July 4 that they may have been exposed to measles.
Cyclospora outbreak sickens 50 people in Florida, health officials say
A cyclospora outbreak has sickened 50 people in Florida, with health officials warning about the risks of consuming contaminated fresh produce.
Pettit Reservoir in Silverton under health warning due to algae bloom
A health warning was issued for the Pettit Reservoir in Silverton on July 10 due to a toxic algae bloom that recently appeared.
New Mexico health officials issue warning ahead of hot weekend
The New Mexico Department of Health on July 9 issued a warning about heat-related illnesses ahead of a hot weekend.
Mississippi mobile sports betting debate resurfaces amid lieutenant governor warning
Mississippi’s debate over mobile sports betting has resurfaced after Lt. Gov. Delbert Hosemann posted a warning on X urging the Senate to reject the measure.
Bat exposure warning linked to Mount Airy fireworks show
Attendees of Mount Airy's July Fourth fireworks show came into contact with bats, the Carroll County Health Department warns.
Ohio Department of Health warning spread of ‘explosive’ diarrhea illness
The Ohio Department of Health (ODH) is warning Ohioans to take precautions as cases of the “explosive” diarrhea illness, Cyclosporiasis, continue to spread throughout the state.
Carville blasts Dems amid Platner scandal, warning they ignored a classic rule of politics and paid the price
James Carville blasted Maine Democrats for failing to vet Platner, saying opposition research on your own candidate is the most important step.
Harford health officials warn of possible exposure after rabid fox confirmed in Bel Air
The Harford County Health Department announced that a fox tested positive for rabies, warning that people and pets in the surrounding areas may have been expose
Storm warning for ACA shoppers: Double-digit premium hikes are coming
The 2027 outlook for the Affordable Care Act is severe.
Hungary moves to overhaul university models banned from Horizon Europe
Hungary’s new government is aiming to overhaul the governance model of the institutions and universities that lost access to Horizon Europe and Erasmus+ funds “in a short timeframe,” according to Péter Horváth, the new state secretary for science policy and innovation. “As of today, the two non-university foundation-controlled institutions under my remit have been transformed,” he told Science|Business. “We hope the universities will follow and that this will be enough to satisfy the EU’s demands.”Under the previous government, led by Viktor Orbán and his Fidesz party, many academic and scientific institutions were restructured and made into special public trust foundations, with members strongly linked to the government given lifelong mandates and significant decision-making powers with little oversight. The European Commission deemed that this undermined academic freedom and transparency in the country, leading to a ban on 34 institutions in 2022, including 21 universities, which saw academics in Hungary lose access to Horizon Europe grants. The new Hungarian government, elected in May and led by Péter Magyar and his Tisza Party, has promised to dismantle this governance model and restore the institutions to EU programmes. As a result, the European Commission has promised to return access to the Erasmus+ education mobility programme, but so far no concrete agreement has been made on the Horizon Europe programme for research and innovation. Hungary has already made legislative changes in June to allow the institutions to be reformed and set a timeline for the implementation.The non-university foundations, which are mainly cultural centres such as the Foundation for Hungarian Culture or the Makovecz Campus Foundation, will all be dissolved by August 31 this year, a date tied to EU-set milestones that Hungary must meet to unlock frozen funds, with control transferred to relevant ministries. Meanwhile, the universities will have until 31 August 2027. For each university foundation, the government will set the dissolution date and the body to take over operations. There is no final decision on a permanent new model for the universities, according to Hungarian MEP Eszter Lakos, who is shadow rapporteur for the Horizon Europe specific programme, a separate piece of legislation detailing implementation rules for the EU’s next research programme, due to start in 2028. “The aim of the transition year is to settle this with [the universities], not to impose a model, and not to put them under state control,” she told Science|Business. “The goal is to give academic independence back to universities.”There are three models that are most likely to be implemented. One would be a return to a traditional, state-run model. Another could be a newer, more self-standing public institution. A third option would be a reformed version of the foundation models that meet EU standards. According to Lakos, the dismantling of the system put in place by the Orbán government is well underway and if all goes according to plan, Hungary could regain access to EU research money by the start of the next academic year in 2027. “I believe that the Hungarian government is doing the necessary changes so the universities could return as beneficiaries to Horizon from the next school year,” she said. In the meantime, “the universities, institutes and cultural assets carry on under proper public stewardship rather than a handful of unaccountable trustees,” said Lakos. The laws passed in June impose new safeguards: board terms are capped at four years and renewable only once, appointments are made through open competitions and sitting politicians cannot join joining these boards.It remains unclear whether a domestic science funding programme set up as a back-up scheme by the former government following the EU funding ban, called HU-rizon, could be continued. “This programme should never have had to have been established in the first place, but it has proven to be quite popular,” he said. “I am considering continuing this programme with a refined focus on helping international collaborations.”Re-organising the research network One of the first priorities for Horváth and his cabinet is to resolve questions over the future of the Hungarian Research Network, Hun-Ren. The network of academic institutes was taken away from the Hungarian Academy of Sciences in 2019 and turned into a quasi-private organisation, with similarities in its governance to the public trust foundations.Horváth and his team have consulted over 5,000 representatives from the network and the conclusion is broad unhappiness with the directors of all the institutes involved. “We have presented the results to the president and the chief executive of the network and this is currently being discussed,” Horváth said. The plan is to re-integrate the network back into the Academy of Sciences but in an improved way, “learning from mistakes of the past,” he added. The government also wants to reintegrate four humanities and social science research centres into the network that the previous government had transferred to Eötvös Loránd University. The transfer brought sharp criticism from the academic community, with a group of Hungarian research heads, including European Research Council grant recipients, sending an open letter to Orbán warning that the transfer would “cause historically significant harm to the entirety of Hungarian scientific life.” The transfer was “one of the biggest shames in Hungarian research in the past 20 years,” Horváth said. “We want to immediately re-integrate them back into the research network and to regain the trust of these institutions, because the way they were treated was really unfair.”Another pressing issue is the Élvonal Excellence Research and Talent Development Foundation, led by Nobel laureate Ferenc Krausz. The foundation signed a financing agreement with the former government earlier this year for a budget of over €730 million over the next five years. The goal is to create a world-class centre to attract top talent from abroad and to develop local researchers. But there was little transparency about this foundation, and news of its huge budget, which is nearly as much as Hungary’s entire research budget, caused a stir in the media following the recent elections. Another issue is that, as with the foundation boards of the institutes banned from Horizon Europe, there was little-to-no oversight of decisions led by Krausz. “It was an excellent idea but an unacceptable execution,” Horváth said of the foundation. “The fact that this is out of the Hungarian funding scheme, mostly concentrating on one person who decides on the budget is unacceptable for us.”The government plans to merge the centre with the National Research, Development and Innovation Office, the country’s R&D funding agency, with a reduced budget. Horváth is hopeful that Krausz will still be involved. The new government’s R&D goalsA phrase that crops up regularly during the discussion with Horváth is “democratic process.” The new state secretary is determined to involve Hungary’s research community in shaping future policies. This marks a departure from the previous government’s approach, and several people in Hungary’s research community have commented on the openness of the new government. In terms of concrete goals, Horváth and his team already have plans. He wants to create a new science fund in Hungary, based on the best practices of other European countries. The fund would not be tied to annual government budgets and would provide long-term, stable financing. “If we were to succeed in creating this fund, then I think it would be one of the biggest achievements for me in this period of government,” Horváth said. On the innovation side, he is looking into how best to bring in the private sector. “We want to make sure that we are working with the private sector to support innovation,” Horváth said. One of his big aims is to introduce entrepreneurship teaching into high schools. Hungary already has a reputable national academy offering research and innovation training in the field of natural sciences, and Horváth wants to expand this to all disciplines and across the whole country. “One of the main ways to elevate our innovative businesses is to teach our children to be innovative,” he said. “This will probably need ten years to pay off, but this is what we should do. Our aim is to make Hungary strong in our region, and this is what is needed.” Related articlesHungary’s Horizon Europe performance in numbersCommission unlocks Erasmus+ cash for Hungary, Horizon could be next‘Academic Huxit.’ Hungarian researchers speak out on impact of EU ban A more difficult task will be funding. The new government is aiming to increase research spending to 2% of the GDP by 2030, and then increase it to 3% in line with EU objectives. Currently, spending sits around 1.3%. But according to Horváth, the current budget, inherited from the previous government, is “heavily in the negative,” so any plans to increase research spending will have to start next year. Achieving 2% by 2030 already needs a big push, almost doubling the research budget. “This is something we’d definitely like to reach, and something I can see us achieving,” he said. “From the 2030s, I’d like to see an innovative generation growing up that can help us reach the 3% target.” Positivity in the new governmentDespite the many challenges facing Horváth and his team, the mood is positive. “It feels a bit like a start-up right now. Everyone is working 24/7, day and night, trying to do as much as they can. There is a lot of energy,” he said. It is a big change for the state secretary who, like many in his cabinet, is coming from a background in research or business, and not in politics. “Six weeks ago, I was sitting with my microscope and my research PhDs, so it’s been a big change for me,” said the computer scientist, who was previously the director of the Institute of Biochemistry at the Hun-Ren Biological Research Centre in Hungary and worked at the Institute for AI for Health at Helmholtz Munich. But he is relishing the task to transform the country’s R&D landscape. “We feel enormous support from the Hungarian people, but also from Europe,” he said. “We’ve received a lot of letters of support from around Europe. There is big trust there, and huge responsibility on our side. We want to get everything back on track, and there’s a lot to do.”
Meta Went Down Twice in 11 Days. The Outages Exposed a Risk Many Businesses Ignore
Two unannounced outages took down Meta's ad tools this June with no warning and no timeline. The brands that barely noticed already knew the answer to a question most never bother to ask.
Rabid bat found in Marion County prompts county health warning
Marion County officials warn after a bat in the Marion area tested positive for rabies. Residents should avoid bats and other wildlife, keep kids and pets away, and ensure dogs and cats are up to date on rabies shots.
Musk-linked mailers draw complaints for targeting wrong addresses, dead voters
Election officials in North Carolina and Georgia are warning about suspicious voter-registration mailers linked to Elon Musk.
NYC health officials warn of Legionnaires' disease outbreak in Central Park area
New York City health officials report a surge of 23 Legionnaires' disease cases on the Upper East Side. Dr. Stephanie Widmer joins 'Fox & Friends' to detail critical outbreak warning signs and discuss biohacker Bryan Johnson's autoimmune diagnosis.
Four states seeking $1.4 trillion in penalties in child social media addiction trial, Meta says
Four states are seeking $1.4 trillion from Meta over claims Facebook and Instagram were designed to be addictive to children without any warnings on the alleged harms of the apps.
Amber health alert for South West before further hot weather
The warning is issued for south-west England as temperatures are expected to rise later this week.
Supporters to rally after Logan Health declines to renew doctor’s contract
A contract decision involving a longtime family physician at Logan Health is fueling a growing controversy in the Flathead Valley, with union leaders warning it
Security firm finds 'first documented' AI agentic ransomware attack
Researchers at Sysdig say they found "a warning sign" of where ransomware attacks are heading.
NYC health officials warn Central Park visitors after Legionnaires’ outbreak grows on Upper East Side
The outbreak is centered around several Upper East Side ZIP codes, with health officials warning residents and recent visitors to seek care quickly if they develop flu-like symptoms.
New York City issues Legionnaires' disease warning for Upper East Side
Two to 10 days after picking up the disease, symptoms could include coughing, muscle aches, and a high fever, health officials said.
Bill Clinton blasts Trump as Americans mark nation's 250th anniversary
Bill Clinton took an apparent swipe at Trump during an America250 celebration in Philadelphia, warning of threats to democracy and institutions.
Many Celebrities Apparently Got The Same Warning Before Going On David Letterman
This would be so stressful.
Trump delivers ominous warning to political opponents at America 250 event
Trump hails U.S. exceptionalism before veering into darkly political speech to usher in America 250
President Trump ushered in the 250th anniversary of American independence on Friday with soaring rhetoric about American exceptionalism before veering into a darkly political speech with warnings about a sinister threat of communism that evoked one of the country’s ugliest chapters.
SBA administrator says small businesses are the American Dream
SBA Administrator Kelly Loeffler joins ‘Fox & Friends’ to discusses how small businesses embody the American Dream. She also highlights the transformative power of enterprise while warning against radical socialist agendas.
SBA administrator says small businesses are the American Dream
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Making Our Own Luck
We are cross-posting a piece that former NIH official Kris Willis wrote for Macroscience. Kris is now the President and Founder of the Woodley Park Institute, for which I’m a board member. Picking winners or hedging bets? Federal science agencies have long wrestled with the question of how to ensure their billions of dollars of grants and contracts result in maximum benefits for Americans. On the surface, it might seem that a goal-oriented, interventionist style of management would be the best policy: prioritize our most pressing problems and distribute funding accordingly.This top-down strategy creates a unique hazard, though: bad choices can send resources in the wrong direction, resulting in slow progress that impedes the delivery of tangible benefits to citizens. Moreover, if decision makers pursue an applied advance when the underlying scientific principles remain poorly understood, they risk costly failures and a loss of support for the research enterprise at large. Examples include Nixon’s 1971 War on Cancer, undertaken on the premise that a cure could be achieved in less than a decade, the drive to build an operational commercial fusion plant by the mid-1990s, and the National Plan to Address Alzheimer’s Disease, which failed to produce the effective treatments and prevention strategies promised by 2025. The contrasting laissez-faire approach is to hedge your bets. If the path to an advance is impossible to predict, then the wisest choice might be to distribute funding to as widely as possible. The main risk of this strategy is that spreading funding thinly may limit the resources available to the most promising research, resulting in the same negative outcomes as the interventionist approach: limited support for the most promising topics, slow progress, and delayed returns. In reality, at science agencies like the National Science Foundation and National Institutes of Health, program managers navigate between these two extremes, setting some funds aside to target high-priority areas and using the rest to cover the widest possible range of meritorious proposals. This middle path seems like the most rational way to proceed, but it still requires making choices. How much should be set aside for high priority topics? What should those topics be? How should we define merit? Expert opinion can provide a helpful guide, but leading experts can have remarkably different opinions about what matters and what should be prioritized. Moreover, experts and administrators alike can be risk averse, giving an edge to high-profile, well-established concepts. What’s really needed is a data-driven framework to help guide decision-making, one that doesn’t simply repackage prestige or incumbency. Recognizing breakthroughs years in advance Many breakthroughs fail to attract funding or recognition at the earliest stages of development. Katalin Karikó, for example, spent years struggling to win grants for work on mRNA that would eventually win her and Drew Weissman a Nobel Prize. Similar stories can be told about Jim Allison’s groundbreaking studies leading to the development of cancer immunotherapy, Stan Pruisner’s demonstration that prions can self-replicate without DNA, or Robin Warren and Barry Marshall’s proof that Helicobacter pylori, not stress, causes ulcers. Yet at some point, the scientific community recognizes and responds to transformative breakthroughs like these. How does that change happen? And what if science funders could identify the areas that are on the cusp of a breakthrough? Those questions led my collaborators and me to study how scientists responded to past breakthroughs. Based on patterns in that data, we developed a means of predicting future breakthroughs, using biomedicine as a proof of concept. It’s worth taking a moment to describe how our approach works. Briefly, our prediction process begins by grouping the 18 million or so peer-reviewed papers in PubMed, the authoritative database of biomedical research, into roughly 50,000 unique topics. A small subset of these topics are so widely acclaimed as breakthroughs that they have been recognized with a major prize like a Nobel or a Lasker Award. We theorized that studying the development of these outliers over time, especially before they gained acclaim, was the key to identifying future instances of them. After defining topics, we chose 21 representative breakthroughs and asked what they looked like before they won prestigious prizes. To answer that question, we re-ran our topic-mapping algorithm repeatedly, winding back the clock one year each time, stringing together the years to follow the progress of each field as it grew and advanced. We found that in each case, the years leading up to a discovery followed a pattern: a burst of papers on a new, rapidly evolving topic, many of which quickly became influential. These characteristics—the percent of papers that are new, the percentage of papers that are brought in from other topics, and the influence of each individual paper—can all be measured separately for any given topic. Together, they act as a predictive signal that is detectable an average of five years before a transformative discovery is made, and up to thirty years before the discovery receives a major prize. Scanning the current research landscape for topics that display this signal allows us to predict what work will likely produce a future breakthrough. Each year we analyzed includes four or five signals, a number that appears to have remained constant across a twenty year time frame. In their classic work on the sociology of science, Bruno Latour and Steve Woolgar established that the desire to participate in a major discovery is an important motivator for scientists as they consider whether they should take up (or abandon) a research problem. Although further work is needed, the simplest explanation for our results is that this behavior is widespread enough to detect at scale. A foundational advance, or something like it, draws the attention of scientists and causes them to change the direction of their research. They vote with their feet, staking their own reputation and careers by publishing on and citing the new idea. That upswell of interest is the foundation of our breakthrough signal. What kind of research does our model identify as a breakthrough? After building a model based on the patterns in our 21 preselected breakthroughs, we tested it by identifying all early signals of discovery from 1994 through 1997. Of the 18 signals we found in that time period, 17 can be traced forward in time to a breakthrough. Examples include super-resolution fluorescence microscopy (see the image above), the directed evolution of proteins and enzymes (Chemistry Nobel, 2018), and sequencing the human genome (National Medal of Science, 2008). The discovery of the role of leptin signaling in obesity is a particularly interesting case study. Around 1950, scientists noticed the existence of a type of lab mouse that suffered from a unique inherited form of obesity. When given the freedom to choose their own diet, these mice ate more than normal and preferred food that was high in fat. Researchers had few clues as to why the animals overate; early experiments pointed to the existence of a soluble ob factor found circulating in the bloodstream that regulated appetite, but its identity was unknown. In 1994, Jeffrey Friedman and colleagues identified and sequenced the ob gene, noting that the protein it encoded appeared to fit the profile of a circulating factor. A year later, a trio of high-profile publications demonstrated that ob was a hormone that regulated body weight and fat deposition by regulating appetite. One of these was co-authored by Friedman, who christened it leptin from the ancient Greek word for thin. Using our model, the data from 1996 make it clear this advance would become a breakthrough. Scientists had flocked to study the biology of the new hormone, generating the flurry of new papers and citations required to produce a signal. One of these demonstrated that serum leptin concentrations reflected the amount of adipose tissue in the human body, providing clinical validation of the earlier mouse studies. Before the identification of leptin, scientists were unable to point to a specific molecule that controlled appetite and adiposity, so that it was impossible to rule out non-physiological causes of obesity; its characterization fundamentally changed our concept of weight gain. In 2010, Friedman and fellow pioneer Douglas Coleman were awarded a Lasker for the discovery. Our work also identifies breakthroughs in clinical practice and behavioral and social sciences, even though these areas are less likely to draw the attention of major prize committees. One example that falls into this category is the introduction of endovascular aneurysm repair, a minimally invasive surgical procedure for the treatment of abdominal aortic aneurysm, a leading cause of death among Americans over the age of 65. Relative to the previous standard of care, it reduces in-hospital mortality by almost four-fold. In 2017, Timothy Chuter received the American College of Surgeons’ prestigious Jacobsen Innovation award for his multiple refinements to the technique. Another under-recognized breakthrough identified by our model is the development of standardized survey instruments to assess the quality of life for HIV+ patients. The antiretroviral cocktails introduced in the mid-1990s reduced AIDS mortality, but treatment came with serious side effects. The new evaluations showed that patients whose disease progressed had worse physical functioning than Americans with other chronic diseases, while those who were asymptomatic maintained a health-related quality of life on par with the overall US population. This evidence made it possible for patients and activists to argue that even in the absence of a total cure, and in spite of the side effects, alleviation of symptoms was a worthwhile priority for clinicians. My colleagues and I have failed to identify any significant recognition for the physicians and health policy experts who pioneered this advance, although in 2016, researchers called for the World Health Organization to set targets for good health-related quality of life as part of its framework to end the AIDS pandemic. From forecasting to funding How should science funders use our predictions? Any serious discussion of what we should do with this new capability needs to begin with an understanding of its limitations. We can’t (and shouldn’t) invest all of our resources in the small number of topics predicted to produce breakthroughs. Innovative new fields are born from existing ones; they rarely arise de novo. If funders don’t maintain a diverse portfolio, the breakthroughs of tomorrow will have no antecedents. Think of this as eating the seed corn, or killing the goose that lays the golden egg. There are also multiple goals of funding beyond basic scientific discovery, including translating discoveries into clinical practice, developing new technologies, supporting economic development, and training new scientists. The investments needed to accomplish these goals are likely different from those required to support emerging breakthroughs. Finally, we must be aware that we may not capture every instance of a breakthrough. The concept is fuzzy, and not every significant discovery is recognized with a major award. Further, breakthroughs are rare, meaning that our dataset is, by necessity, small. This makes formal estimates of accuracy challenging. Although our overall success rate appears to be high, any one signal may turn out to be a false positive. We found one apparent example: the development of the third generation COX-2 inhibitors, Vioxx and Celebrex, which were much celebrated in the early 2000s as effective but non-addictive pain relievers, meets all the algorithmic criteria of a breakthrough. Five years after it received FDA approval, researchers demonstrated that Vioxx was associated with serious cardiovascular complications, and the manufacturer voluntarily pulled the drug from the market. Celebrex remains available, although like other NSAIDs, it carries an FDA warning for increased cardiovascular risk. Decision makers who were overly focused on the breakthrough potential of this research might have wasted substantial resources nurturing an area that ultimately proved to be a failure—but so would those who relied on expert opinion at the time. That said, the potential benefits of funding the next mRNA vaccine or cancer immunotherapy years earlier than we might have are large. When we can’t assume the outcome of an action, it’s worth conducting an experiment. Can targeted support for areas that are poised to produce a breakthrough increase the return on scientific investment without cannibalizing future advances? With the necessary administrative infrastructure in place, conducting this experiment would be straightforward. First, identify all the breakthrough signals between 2018 and 2023, select half at random, and commit to a decade of investment. For biomedicine, a six year window should yield about 30 topics with the potential to produce a breakthrough. Providing strong support to half of these might be accomplished for $300 million a year. That’s roughly half of the recent annual budget of the NIH Common Fund or around 20% of the fiscal year 2025 budget for ARPA-H. After five years, then again at ten, compare to see which group — the one that was actively managed, or the control — produced more breakthroughs, and on what timescale. Although we used biomedicine as an example, the same experiment could just as well be run for physics, materials science, or any other discipline. Any attempt to undertake such an experiment should keep three points top of mind. First, we can predict the topic of future breakthroughs, but the people and vision for how to move the work forward are still important. In practice, this means success requires active program managers with the expertise to develop the science and the authority to do so, including by recruiting investigators. Second, we would be wise to learn from the failures of past attempts to fund transformative research. High among these are funding modestly repackaged work, confusing the genuinely novel with the merely unfamiliar, and relying too much on incumbent investigators. All of these risks can be mitigated by thoroughly and intelligently integrating high quality data into portfolio management. Finally, we need to have patience. Even with strong funding support, producing a breakthrough takes time. If supporting breakthroughs is the best way to nurture the birth of new fields, we also need to accurately describe and properly manage the other two stages, so that we invest wisely throughout the productive lifetime of ideas and divest once they reach the point of diminishing returns. We would benefit from more study of all of these phases, especially the transition from one to another. More research could answer questions like: When does a breakthrough become an established field? How do the availability of funding, the size and characteristics of the available workforce, and the accumulation of evidence that disagrees with prevailing models affect a field’s decline? Exactly how do old ideas give birth to new ones, and can we speed up the process? The more we understand about the dynamics of scientific progress, the better we can maximize the odds that our curiosity leads to results. I’d call that finding a way to make our own luck.
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How should European scientists respond to the US AI kill switch?
Earlier in June, Europe’s worst fears of technological dependence were confirmed when the White House ordered the AI firm Anthropic to stop non-US citizens using its leading models. This kill-switch moment crystalised anxieties in Brussels that the continent, lagging the US on the creation of leading-edge AI models, is now a technological of vassal of Washington. The shock has specific implications for European scientists and universities. Some governments are now worried that with AI being integrated into labs, Donald Trump now has his finger hovering over an off switch for European science. “Having restrictions on this tool, it can have an impact on our own research,” said France’s research minister, Philippe Baptiste, at the VivaTech conference in Paris on June 18.Baptiste, himself a former academic, said that colleagues in mathematics had recently warned him they were now cut off from leading-edge US models, risking their work. “This model is not available anymore now because of the US restriction, and for the first time this had an impact on mathematics,” a field where large language models (LLMs) are making a significant contribution, said Baptiste. So, should European scientists avoid relying on US models in the future? Or would this be a self-harming overreaction? And how is AI being used in science, anyway? What happened?On June 12, it emerged that Washington, citing cybersecurity concerns, had ordered Anthropic to stop non-US citizens using two models: Claude Mythos 5, and Claude Fable 5, a version of Mythos but with guardrails to prevent abuse. Anthropic said Washington’s concerns were overblown. But forced to follow the order, yet with no way to check who was using the models, the company suddenly shut down access for everyone, US citizens included. There’s still no agreement on how to restore broad access. But last week, Bloomberg reported that select US companies, and the US government, still had access to Mythos despite the ban, but the EU’s cybersecurity agency Enisa had been shut out. Class division of researchersIn the longer term, access outside the US should be restored, said Marcel Salathé, co-director of the AI centre at the Federal Polytechnic School of Lausanne (EPFL), because a permanent restriction would be financially ruinous to US AI firms. “Even Trump will eventually budge to economic pressure,” he said.However, US AI firms might end up operating rather like banks, doing due diligence on users of their leading-edge AI models, he went on.European scientists are unlikely to fall foul of such checks, he said. But having a Chinese postgraduate in their lab, or doing a type of research the US disapproved of, could potentially result in access being denied. “It will create a sort of class division of researchers,” he said. More than frontier modelsHowever, successfully deploying AI in science is about far more than just having access to leading LLMs such as Mythos.Instead, many science-specific tools, most famously Alphafold, which predicts protein folding structures, require “far less” computing power to train than frontier models, well within the capabilities of European supercomputers, according to a recent analysis by the Arq Foundation, a Brussel-based AI think tank. Instead, tools such as Alphafold are possible because certain fields, like protein folding, weather prediction or astronomy, have large, clean, standardised datasets that can be used to train predictive models. Rather than compute, “data is the central constraint for AI for science,” the report says. For example, a less powerful physics model trained on CERN’s data “will be more valuable than the best model without certain data,” said Bengüsu Özcan, author of the report. European advantage?Europe could therefore steal a march by using its scientific data and infrastructure to create models US digital giants cannot. “They might actually match or go even beyond what these big [US] companies are doing,” said Özcan.Indeed, some European start-ups hope to create automated testing labs to create the kind of standardised data that could speed up the discovery of new materials. Materials scientists say there’s currently too little data to train models. AI scientistsHowever, even if the bottleneck for AI in science is often data, rather than compute, being at the mercy of the US for LLM access could still become a problem for European scientists. A new class of “AI scientists” based on leading LLMs is also emerging, Özcan’s report says.Unlike domain-specific tools like Alphafold, these try to automate day-to-day scientific work, by providing an overarching tool that coordinates specific models to synthesise existing literature, generate hypotheses or run analysis of data. The problem for Europe, however, is that these tools are sometimes based on US leading models. Google Deepmind’s AI Co-Scientist, for example, is built on Google’s Gemini LLM. Systematic failureThese scientific automation tools are still in their early stages, and still exhibit “systematic failures on scientific tasks,” Özcan’s report says. One of the problems is that the messy, day-to-day process of scientific discovery is largely not documented, meaning LLMs don’t have a good source of data to learn how scientists actually work. Meanwhile, some tasks, such as literature synthesis, don’t typically require access to leading edge models.However, the performance of AI scientific assistants could improve as companies such as Google pour resources into developing them. Rely on US“Unfortunately, for scientific assistants, there is not much we can do right now except rely on US frontier AI,” said Antoine Bosselut, a natural language processing expert based at EPFL. Chinese-built open models, which can run on local computers, lessening the risk of a shutdown, are touted as one alternative to US dependence. There’s also Mistral, once seen as Europe’s main AI hope, but the Paris-based company has seen its recent models fall behind in performance. But the Chinese alternatives are generally not as capable as US frontier AI models, said Bosselut, unless paired with fiddly, custom tools that allows them to act as independent agents. “Most scientists do not have the time,” he said. Don’t jump ship yetAlthough the kill switch moment is seen a warning shot for European scientists, it doesn’t mean labs should abandon US AI tools immediately. “I do not think the right response is simply to abandon US-based models and systems under the banner of sovereignty or independence,” said Mattias Björnmalm, secretary general of the Cesaer university association. “That would be an overreaction.”Related articlesEuropean sovereignty in AI requires ‘ugly trade-offs,’ say experts Robotic lab start-up makes case for €500M EU-funded materials testing facilityAI in science: is it useful? Instead, European researchers need to ask themselves whether they’re becoming dependent on technology that could be turned off in Washington, said Özcan. “They might not see this today, but they should really start asking this question,” she said. European researchers need a plan B, said Salathé. “I would recommend to every researcher, very proactively explore alternatives.”Own toolsIn addition, Björnmalm and others want European research institutions to develop their own scientific AI tools.Instead of signing AI deals with US digital giants, European universities should be using this money to create their own models, which may end up being superior for research, said Sabine Leonelli, an expert on the use of AI in science at the Technical University of Munich. “Universities in Europe seem to be happy to sign commercial contracts with US companies on the assumption [their AI tools] are better,” she said. But US frontier LLMs are typically opaque, and have been developed without independent scientific input, she said. “This is not good enough for science.”Last year, Swiss researchers released Apertus, an LLM designed to be completely transparent, from its development methods to its training data. The idea is that this makes scientific tools built on top of the model far more reproducible than with closed, commercial alternatives.“Europe needs more of this: serious capacity-building that gives researchers, universities and companies credible options,” said Björnmalm.
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