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High school sports results for Saturday, April 25, 2026
SATURDAY’S RESULTS Baseball NON-SECTION Ligonier Valley 4, Laurel Highlands 2 Softball NON-SECTION Neshannock 13, Elizabeth Forward 0 (5) Wilmington...
Advancing Women’s Healthcare With AI: Mammogram Radiology
AI improves women’s healthcare by enhancing imaging, personalization, and addressing longstanding gender bias in research.
Aggressive “hulk” lizards are wiping out millions of years of evolution
For ages, wall lizards coexisted in three distinct color types, each with its own strategy for survival. Now, a powerful green variant is taking over. These dominant “Hulk” lizards are outcompeting the others, causing yellow and orange morphs to vanish. It’s a dramatic reminder that evolution can flip the script much faster than expected.
Two Crows’ ‘Chesapeake’ lets the dogs out at the Slowpoke Lounge
Elizabeth Ledo plays all the parts in Lee Blessing’s 1999 play about a performance artist who goes to great lengths to fight a conservative senator.
A Precolonial Paradox? Rethinking Political Centralization and Its Legacies -
A Precolonial Paradox? Rethinking Political Centralization and Its Legacies By Martha Wilfahrt, University of California, Berkeley A paradox has emerged in the growing literature on the legacies of the precolonial past: areas home to precolonial [...]
Fitbit 4.68 rolling out sleep editing, motivational Coach messages, more personalization
In addition to the Sleep Score redesign, Fitbit this week is rolling out version 4.68 of the Android and iOS apps as a sizable update.
Elizabeth Banks talks sexual health, reproductive care in revealing chat
Elizabeth Banks had a lot to about women's health and menopause over brunch and a revealing game of \
US health officials nix publication of a study on COVID vaccine effectiveness
U.S. health officials have stopped the publication of a study on the COVID-19 vaccine's effectiveness in preventing hospitalizations.
HHS rejects publication of study showing Covid-19 vaccines prevent hospitalizations, ER visits
Covid-19 vaccines roughly halved the chances that a US adult would need to visit the emergency room or be hospitalized with their infections last fall and winter, according to two sources familiar with the findings of a new study. But you won’t hear about it from the agency that led the research: the US Centers for Disease Control and Prevention.
How can scientists visualize cellular life with greater precision? - Salk Institute for Biological Studies
Highlights Salk researchers collaborated with scientists at Albert Einstein College of Medicine to develop a new class of probes for imaging living cells The probes, called visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), generate high-contrast images with minimal disruption to normal cellular activity The technology enables more precise investigation of complex biological processes, including cell signaling, development, and disease progression LA JOLLA—Fluorescent proteins have revolutionized science, enabling researchers to tag and visualize individual molecules in living cells, tissues, and animals. Using these tools, researchers have watched viruses infect cells in real time, observed cellular trash collection, and tracked the signaling that spurs tumor growth.
How Al Gore Politicized Climate Science
An Inconvenient Truth turns 20 next month. In the 2006 documentary, former vice president Al Gore argued that human-driven climate change was an urgent, civilization-threatening crisis. The film became a cultural phenomenon, winning two Academy Awards and making climate change one of the defining political issues of our time. I am sure that there will be many retrospectives seeking to relitigate the scientific claims in the film. But the far more important anniversary story is not about the accuracy of any of Gore’s individual claims but rather about what the film helped to unleash in the scientific community: bringing partisan politics into the institutions of science. Gore did not simply make a film about climate change: He implored the scientific community to join him in overt climate advocacy. The fuel that Gore added to the fire of pathological politicization of the climate science community is the most important legacy of An Inconvenient Truth. Almost three years after the film’s release, Gore took the stage at the 2009 annual meeting of the American Association for the Advancement of Science (AAAS)—the country’s largest and most prominent scientific organization—and delivered something much closer to a revival sermon than a scientific lecture. Gore told the assembled scientists that they could no longer “in good conscience accept this division between the work you do and the civilization in which you live.” His directive was clear:
Adobe Enterprise CMO explains how AI helps scale personalization
AI enhances marketing efforts, says Adobe Enterprise's Rachel Thornton, citing Ulta's approach to personalizing customer journeys with AI insights.
Warsh vows to keep monetary policy independent of politics
STORY: :: Fed chief nominee Warsh vows to keep monetary policy independent of politics:: Washington, D.C. / April 21, 2026:: Kevin Warsh, Federal Reserve chief nominee“Monetary policy independence is essential. Monetary policymakers must act in the nation's interest. Their decision is the product of rigor, deliberation and unclouded decision-making. And as Senator Warren said, I do not believe that independence of monetary policy is threatened when elected officials state their views on rates. Fed independence is up to the Fed." // :: Sen. Elizabeth Warren, Ranking Democrat on Senate Banking Committee“So, independence takes courage. Let's check out your independence and your courage. We'll start easy. Mr. Warsh, did Donald Trump lose the 2020 election?”WARSH: “Um, we try to keep politics, if I’m confirmed, out of the Federal Reserve.”WARREN: “I’m just asking you a factual question. I need to know. I need to measure your independence and your courage.”WARSH: “Senator, I believe that this body certified that election many years ago.”WARREN: “That’s not the question I’m asking. I’m asking did Donald Trump lose in 2020?”WARSH: “And I’m suggesting to you in 2020…”WARREN: “I’m suggesting you can’t answer that.”WARSH: “… the Fed had a huge inflation problem, and you certified the election…[crosstalk]… let’s keep the politics out of monetary policy.” //WARREN: "Just one little place where you disagree with Donald Trump.”WARSH: “Well, I do have a disagreement actually, Senator, with the president. I think even this morning, he said that he thought I was out of central casting. I think central casting, I'd look older, grayer, maybe show up here with a cigar of sorts.”WARREN: “Quite adorable. But, you know, we need a Fed chair who is independent. That's the only way we preserve the independence of the Federal Reserve. If you can't answer these questions, you don't have the courage and you don't have the independence.”In a confirmation hearing before the Senate Banking Committee that quickly hinted at major changes to come at a Warsh-led Fed, the 56-year-old lawyer and financier blamed the central bank for an inflation surge in the wake of the COVID-19 pandemic that continues to hurt U.S. households.Warsh's hearing quickly turned contentious. Democratic Senator Elizabeth Warren pressed Warsh on his independence and "courage", saying President Donald Trump had made clear Warsh would be his "sock puppet".
Warren grills Warsh on whether he's Trump's 'sock puppet'
Sen. Elizabeth Warren grilled Fed chair nominee Kevin Warsh during his confirmation hearing on Tuesday.
WhatsApp Testing Paid 'Plus' Subscription Tier
WhatsApp has started testing a paid subscription tier called WhatsApp Plus, which adds a set of personalization options on top of the standard messaging experience, according to WABetaInfo.
A ‘burgeoning black market’, inflated dosing and the over-judicialization of health care: reporters around the world tell stories about Keytruda
In a yearlong investigation led by the International Consortium of Investigative Journalists, reporters from more than 37 countries found the cancer drug’s high price impacts patients and health systems differently.
Christina Applegate addresses health concerns after reported hospitalization
Christina Applegate returns to social media with gratitude and admits she's getting stronger every day while focusing on her MS-related health issues.
Franciscan Health blesses new St Elizabeth Garden
Built on a former school site, the St. Elizabeth Garden offers a new educational and reflective space at Franciscan Health.
Graham Platner nets another endorsement in high-interest Maine Senate race
Sen. Elizabeth Warren calls Maine Democratic Senate candidate Graham Platner "a real fighter" who's ready shake things up and make changes in DC.
Christina Applegate Breaks Silence Amid Hospitalization Reports
"Thank you for the outpouring of love and well wishes," the actress shared on Instagram Monday with her 1.1 million followers.
Dwayne ‘The Rock’ Johnson coming back to Atlanta for ‘Lizard Music’ film
Dwayne "The Rock" Johnson will be back in Atlanta this summer to film the movie "Lizard Music", which will be written and directed by Benny Safdie.
Moss for ProMarket: How the Professionalization of College Sports Changed Who Wins
The new model in the United States of paying college student athletes emerged from a complex settlement in the 2025 House v. NCAA private antitrust class action. The settlement supercharged Division I schools’ incentives to fund high-revenue sports programs because they need to pay for millions of dollars in required revenue-sharing with their student athletes. The prospect […]
The marijuana of my youth is long gone. I wish someone had told me
Marijuana legalization is growing — and so is the potency of today’s weed. It’s a lesson this reporter learned the hard way.
How the Professionalization of College Sports Changed Who Wins
The House v. NCAA private antitrust settlement professionalized collegiate sports by requiring colleges and universities to compensate student athletes. The case has changed the economics of college sports, pushing schools to spend big to pay for top athletes to field teams that compete for championships. New research from the Progressive Policy Institute finds that although the new model has narrowed success to the top programs, the ability for schools to pay for success has now been mostly priced in, writes Diana L. Moss.
Advancing epidemic and pandemic preparedness through research readiness: SEAR Unity Studies Network Sites chart the way forward in 2026
On 25 March 2026, WHO Regional Office for the South‑East Asia Region (SEARO) convened the first meeting of the SEAR Chapter of the Unity Studies Network Meeting in 2026 to take stock of progress and plan next steps for strengthening epidemic and pandemic preparedness across the Region. The meeting focused on reviewing the ongoing adaptation of selected, standard Unity Study methodologies, sharing field implementation experiences from 2025, and identifying key priorities to guide collaborative work in 2026.Held virtually, the meeting brought together representatives from six Unity Studies network sites across five countries (Bangladesh, India, Nepal, Sri Lanka, and Thailand) as well as participants from all three levels of WHO.The meeting took place against the backdrop of ongoing regional efforts in South‑East Asia to strengthen early investigations and studies for epidemic and pandemic preparedness, with a focus on pandemic influenza and other emerging respiratory pathogens with epidemic and pandemic potential. In this context, and as part of preparedness for the rapid generation of evidence, the WHO Health Emergencies Programme in SEAR (WHE/SEAR) encourages Unity Studies sites to adapt prioritized, standardized Unity Study protocols to their national contexts. This approach supports the generation of timely and reliable evidence to inform public health decision‑making during epidemics and pandemics.These efforts are supported through a combination of experience sharing, participation in the global Unity Studies network webinars, capacity‑building of the national public health workforce, and regional collaboration that promotes inter‑country, inter‑agency, and inter‑ministerial action. In parallel, sites are encouraged to explore diversified funding sources to help sustain research preparedness over the long term.Discussions highlighted the importance of WHO’s catalytic financial support through the Pandemic Influenza Preparedness (PIP) Partnership Contributions (PIP‑PC). When combined with national and institutional resources, this support enables countries and sites to maintain continuity of activities at a core level and remain prepared to respond rapidly and effectively to future epidemics and pandemics.Regional and Global Updates: Opening the session, Dr Pushpa Ranjan Wijesinghe, Programme Area Manager, Pandemic and Epidemic Management (PEM) Unit, WHO Health Emergencies Programme, highlighted the progress made in operationalizing the Unity Studies Network across the Region and acknowledged the collaborative efforts of WHO at all three levels, together with country unity studies sites. He emphasized the availability of limited but catalytic funding through the Pandemic Influenza Preparedness (PIP) Partnership Contribution (PIP‑PC) workplan at SEARO to sustain network activities in 2026, while encouraging sites to leverage additional funding sources to expand implementation.Representing SEARO, Dr Ashok Basnet, consultant, Pandemic Influenza Preparedness reported that, at the regional level, the Unity Studies Network currently includes six sites across five countries: Bangladesh, India, Nepal, Sri Lanka, and Thailand. He noted that in 2025, catalytic funding supported protocol adaptation, training, and pilot implementation. In addition, a regional Unity Studies symposium held during the Global Public Health Summit in Sri Lanka strengthened and advocated collaboration between the Unity Studies site, national decision‑making forum, relevant technical units of the ministry of health, WHO and other partners.The symposium also highlighted the role of early investigations and studies as a key component of a multi‑source surveillance system needed at country level to generate a broad range of evidence. It underscored the critical role of country Unity Studies sites and similar research entities in generating evidence to support public health decision‑making during epidemics and pandemics.Participants of the WHO GISRS Unity Studies Sites Network- SEAR Chapter Meeting 2026 (Photo credit- PEM/WHE/SEARO). SEARO also updated participants on ongoing efforts to develop a regional Unity Studies webpage and to promote participation in global knowledge‑sharing platforms, including webinars and the WHO Community of Practice. Priorities for 2026 include supporting the implementation of Unity protocols, strengthening collaboration and experience sharing across sites, documenting and publishing findings, integrating Unity Studies activities as a component of multi-source national surveillance systems, and building workforce capacity.Dr Nickle Boddington of the Global Influenza Programme (GIP) at WHO Headquarters, which coordinates the Unity Studies Network globally, provided updates on global Unity Studies activities, noting that the network has expanded to 16 sites worldwide. New and updated protocols, including rapid clinical severity assessment tools and standardized data platforms, are being developed to support implementation. The global Community of Practice has also been launched to facilitate technical exchange, and continued support will be provided to sites for protocol adaptation, ethical approvals, and readiness for early investigation during outbreaks. Updates from Unity Studies sites in SEAR in 2025Unity Studies sites shared progress and experiences in implementing protocols across diverse country contexts. Sites initiated activities in 2025 using catalytic funding from SEARO, complemented by the mobilization of internal national resources. The Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh, reported the adoption and piloting of investigation protocols on non‑seasonal influenza and emerging respiratory diseases during recent avian influenza outbreaks, demonstrating a multi‑source funding approach involving government, WHO and One Health partners.The Hamdard Institute of Medical Sciences and Research (HIMSR), New Delhi, India, highlighted the piloting of household transmission investigation studies, the expansion of the national Unity Studies network, and the contribution of study findings to global evidence through published outputs. The All-India Institute of Medical Sciences (AIIMS), New Delhi, India, shared experiences from large‑scale seroprevalence studies conducted during the COVID‑19 pandemic, recent efforts to strengthen national Unity network sites through training activities, and plans to initiate multi‑centre studies on respiratory viruses.Similarly, Prince of Songkla University, Thailand, highlighted its experience in developing integrated surveillance and diagnostic protocols for multiple respiratory pathogens, enhancing readiness for targeted investigations of emerging threats. The University of Sri Jayewardenepura, Sri Lanka, reported ongoing engagement with the Ministry of Health and exploration of additional funding sources to initiate studies. Meanwhile, the National Public Health Laboratory, Nepal, provided updates on continued coordination with national stakeholders to initiate implementation, despite delays related to the country context.Across sites, shared experiences underscored the importance of protocol adaptation, multisectoral collaboration, and sustainable funding to operationalize Unity Studies and generate evidence for public health action.Discussions and Way ForwardThe meeting reinforced key priorities for 2026, including strengthening unity studies protocol implementation, enhancing collaboration, knowledge sharing, integrating research as a component of national multi-source surveillance systems, and ensuring that generated evidence informs public health decision‑making. Participants also emphasized the importance of documentation, visibility, and leveraging multiple funding sources, and agreed on the following action points.Unity Studies Sites and WHO Country Offices:Advance adoption and implementation of at least one Unity protocol, continuing activities initiated in 2025 with catalytic funding, supplemented with other sources of funding where feasible.Document site-specific experiences, outcomes, and lessons learned; participate in regional and global knowledge-sharing platforms including WHO webinars and the Community of Practice.Work closely with ministries of health to establish unified national platforms for translating generated evidence into national public health decision-making. WHO Country Offices may facilitate technical support and complementary, synergistic funding opportunities where feasible. WHO Regional OfficeCoordinate with WHO Country Offices to support implementation of core unity studies activities by network sites through catalytic funding and provide technical guidance and virtual engagement opportunities throughout 2026.Facilitate the participation of all Unity Studies sites in the regional meeting on Unity Studies implementation in October 2026, to be held back‑to‑back with the Annual SEAR Regional PIP‑PC Meeting; develop and host a SEAR Unity Studies website; and mobilize support from academic institutions within the SEAR Unity Studies Network to support the development of regional manuscripts that showcase Unity Studies activities to scientific audiences and promote knowledge‑sharing.Explore complementary funding opportunities and partnerships to sustain and expand network activities across the Region.WHO HeadquartersProvide global technical guidance, updated protocols, and toolkits to support the implementation of Unity Studies in SEAR.Facilitate engagement of SEAR sites in global webinars, the Community of Practice, and opportunities to showcase their work.Support joint publications, inclusion of SEAR experiences in global outputs, and identification of additional funding and collaborative opportunities to strengthen Unity Studies activities.
Tapper to Stefanik: ‘Is calling for wiping out an entire civilization bad or good?’
Tribune Editorial: Utah officials need to raise the alarm about measles
It’s a disease that can cause misery, hospitalization, birth defects, swelling of the brain, deafness, a weakening of the immune system that can last for years and, on rare occasions, death.
Centipede consumption boosts growth and gut health in endangered crocodile lizards
A new study in Biological Diversity reveals that centipede consumption enhances growth and gut microbiome homeostasis in juvenile crocodile lizards by enriching beneficial fermentative bacteria and elevating short chain fatty acid production, underlining the critical role of dietary diversity in the conservation of endangered reptiles.
Beyond Prompting: Using Agent Skills in Data Science
How I turned my eight-year weekly visualization habit into a reusable AI workflow
How Elizabeta Gjorgievska Joshevski built a global tech career and is now shaping AI strategy for enterprises
Elizabeta Gjorgievska Joshevski explains how EverCognitive helps companies approach AI transformation with strategy, readiness, and measurable business outcomes.
Shannon Elizabeth joins OnlyFans after Hollywood 'controlled' her career
Shannon Elizabeth, known for "American Pie," says she joined OnlyFans to take control of her career and show a "more sexy side."
Avoid these common small business tax mistakes
Block Advisors Strategy and Small Business Program Manager, Latasha Randle, chats with Host, Elizabeth Gore, about how self-employed entrepreneurs can simplify taxes, retirement, and healthcare planning. Randle shares practical advice on staying organized year-round, maximizing deductions, and building long-term financial security through proactive planning.
Life-threatening virus that causes vomiting and diarrhea at high levels in the U.S., CDC says
Rotavirus is highly contagious, fast-moving and especially dangerous for babies and young children. Doctors worry declining vaccination rates could lead to more hospitalizations.
Black Maternal Health Week: PRH in Action
PRH highlights Black Maternal Health Week 2026, addressing pregnancy criminalization, racial inequities, and solutions for equitable care.
Bill to expand subacute mental health care access goes to governor's desk
A bill that aims to expand access to subacute mental health care, which is one step below hospitalization, is on its way to the governor’s desk.
This comet is ‘regrowing’ its tail in space and scientists compare it to a lizard
Science News: It has long been an exciting area of study for many people to observe comets in the night sky, but according to a recent observation as published in ‘.
How U.S. News Ranks Business Schools By MBA Specialization In 2026
Babson President Stephen Spinelli talks to P&Q about the end of his school's 32-year streak as the top-ranked entrepreneurship program.
Politics Unplugged Podcast: Laura Gersony on the SRP election and Turning Point's impact
Arizona Republic reporter Laura Gersony joins us to talk about the SRP election, and why it was a loss for Turning Point USA. Then Dennis and Colin talk about the President’s threat to end a civilization and Melania Trump's Epstein-focused press conference.
'American Pie' star Shannon Elizabeth recalls dancing for Jason Biggs in 'difficult' audition
Shannon Elizabeth says the 'American Pie' Barenaked Ladies scene was flipped for her audition — meaning she hd to dance for Jason Biggs: 'I was really scared.'
Illinois Court Hears Final Lawsuit Challenging Marijuana Social Equity Business Licensing Lottery
“We just want a fair shot. We’re not asking for anything special, no special privileges, but what they promised from the very beginning.” By Hannah Meisel, Capitol News Illinois Nearly seven years after Illinois lawmakers approved recreational cannabis legalization, applicants who lost out on coveted business licenses are still battling the state in court, alleging […]
MacBook Neo punches above its weight in Windows 11 gaming test
YouTuber ETA Prime has tested Windows 11 on the MacBook Neo through a virtualization app called Parallels. With full 3D hardware acceleration, the Apple A18 Pro SoC smoothly ran some Windows games on it as well.
Isla Vista Businesses Share Exclusion Concerns After Soltopia Festival
While Soltopia succeeded in lowering arrests, citations and hospitalizations compared with past Deltopia events in Isla Vista, some business owners felt
Animal Science Major Finds Familiar Sense of Community on the Farm
Elizabeth Reed left her hometown seeking a fresh start. Her determination and passion for livestock led her to leadership, and a close-knit community at the University Farm.
Grim new economic numbers highlight how Trump is losing leverage against Iran
The week began with President Donald Trump saber-rattling like we’ve never seen before. He threatened apparent war crimes and to end a “whole civilization” if Iran didn’t meet his demands.
Gemini gains the ability to create interactive simulations
And you can change their parameters on the fly. The latest Gemini feature lets Google's AI generate interactive simulations and models. With this, Gemini...
Ohio wants to ban mobile sports betting. It's about time
Ohio’s legalization of sports betting has turned a game into something with much higher stakes.
West Ninth Street Black business district aims to echo the past, but with a modern twist
The new Black business district blocked off part of the street, which will remain that way until Juneteenth, with the project aiming to realize the historical significance and hopeful revitalization of the area.
Republicans block effort to halt Trump's war with Iran after 'civilization' threat
House Democrats tried to force a vote on a war powers resolution during recess. Senate Democrats will launch a more serious attempt to rein in Trump when Congress returns next week.
A conversation with Sir Michael Marmot
How the realization that health outcomes are directly tied to social status led to a framework to reduce health inequalities.
A more transparent, connected experience in Web of Science Research Assistant
The latest Web of Science Research Assistant update introduces a unified entry point, greater AI transparency, and new author and visualization tools that enhance the user experience.
Listen up: This is the leadership skill that businesses underestimate
New research debunks the introvert advantage. Plus: The U’s Technology Commercialization office marks a milestone.
‘The nuclear button for the Vatican’: Pope Leo steps into the political fray
The pope has long spoken about injustice in moral terms. This week, Trump’s threats to end “civilization” in Iran prompted him to cross into explicitly political territory — a move Vatican historians call extraordinarily rare.
Seton Hall to Host LaLiga Delegation for Presentation on Globalization
Join us for a presentation led by Alex Requena on the globalization of the sports industry, featuring an international delegation from LaLiga.
Seton Hall to Host LaLiga Delegation for Presentation on Globalization
Join us for a presentation led by Alex Requena on the globalization of the sports industry, featuring an international delegation from LaLiga.
How the Journal Covered Trump’s 12-Hour Iran ‘Civilization’ Countdown
Plus, the White House decided to hang on to Kristi Noem’s $70 million jet.
Rosenberg: Viola, Liza, and two more audiobooks with showbiz roots
New works from two EGOTs – that’s Emmy, Grammy, Oscar and Tony winners Viola Davis and Liza Minnelli – along with a fine novel set in the country-music world and
SGMC Health Enhances Hip Replacement Surgery with IntelliJoint® HIP Technology
SGMC Health is advancing orthopedic surgical care in South Georgia with the utilization of IntelliJoint® HIP, an advanced technology used during hip replacement surgery by orthopedic surgeon Anthony D’Abarno, DO. Hip […]
Trump's message to Iran on deadline day: 'A whole civilization will die tonight'
The extraordinary threat signaled Trump's willingness to authorize U.S. military strikes on Iranian infrastructure if no ceasefire deal is reached by 5 p.m. PDT Tuesday.
The world’s “oldest octopus” was never an octopus
A famous “oldest octopus” fossil has been exposed as a case of mistaken identity. Advanced imaging revealed hidden teeth showing it was actually related to a nautilus, not an octopus. The confusion came from decay that altered its shape before fossilization. This discovery rewrites part of evolutionary history, pushing the true origin of octopuses much later in time.
Scientists discover reversible male birth control that stops sperm production
Scientists at Cornell University may be closing in on the long-sought “holy grail” of male contraception: a safe, reversible, nonhormonal method that completely halts sperm production. In a breakthrough mouse study, researchers used a compound called JQ1 to temporarily shut down meiosis—the critical process that produces sperm—without causing lasting harm. After treatment stopped, sperm production bounced back, fertility returned, and the animals produced healthy offspring.
What to watch for in WPIAL sports on April 6, 2026: West Mifflin, Elizabeth Forward to meet in softball
All is quiet on the day after Easter in district baseball as the section series for this week will run Tuesday and Wednesday.
CMS announces data release on health care utilization and prices
The Centers for Medicare & Medicaid Services April 2 announced the release of new data on health care utilization and prices at the provider and service level in open, machine-readable formats under an open license.
Guardians share extreme, vulgar threats from bettors. 'It's a cesspool'
The legalization of sports betting has led to a flood of angry, sometimes threatening and violent messages from angry sports bettors to players.
Fairfield eyes North Texas Street makeover with grant funding for local business owners
Building brighter and more vibrant businesses in Fairfield is the goal of the city's newly launched North Texas Street Revitalization Program.
Timeout: How sports specialization affects growing bodies and opens youth athletes to avoidable injuries
Megan Thee Stallion Misses Moulin Rouge Shows Hospitalization, Sets Return
The Grammy Award-winning rapper was hospitalized on Tuesday night and "has since been treated, discharged and is now resting," her rep shared with The Hollywood Reporter.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
‘Knife fight’ politics take a mental health toll on SF leaders
After Supervisor Jackie Fielder’s hospitalization, officials speak out about pressure, stigma, and survival.
New state mental health center set to open doors in Newark
The crisis receiving stabilization center is a final link in the crisis response system NJ launched four years ago with the 988 hotline.
How polling failures, gambling legalization and political gridlock paved the way for the explosive rise of prediction markets
While media outlets are signing deals with Polymarket and Kalshi for their insights into the wisdom of crowds, gamblers are pouncing on opportunities to wager on geopolitics and celebrity weddings.
Double-digit increases predicted for NJ public worker health plans
Public worker health plans are expected to see more double-digit rate hikes amid stubbornly high utilization and more municipal departures.
Championing Mental Health Equity: Liza Li’s Journey from Luskin to Community Impact
Liza Li reflects on fellowship recognition, UCLA Luskin training, and her commitment to culturally responsive mental health care for older adults and AAPI communities.
‘Press Your Luck’ hosted by Elizabeth Banks to shoot in Trilith Studios in April
The game show, which was rebooted in 2019, begins filming next month at Trilith Studios in Fayetteville.
Photo of ram’s horn squid shell
The intricate ram’s horn squid shell is only about the size of a fingernail. Compared to other cephalopod species, the shell structure has not degraded over time. As part of this study, researchers used transcriptomics which revealed genes supporting biomineralization and regeneration of the shell.
Lost in space: Microgravity makes sperm lose their sense of direction
Making babies in space may be more complicated than expected, as new research shows sperm struggle to navigate in microgravity. Scientists found that while sperm can still swim normally, they lose their sense of direction without gravity, making it harder to reach and fertilize an egg. In lab experiments simulating space conditions, far fewer sperm successfully made it through a maze designed to mimic the reproductive tract, and fertilization rates in mice dropped by about 30%.
Becker's Hospital Review lists 22 strong health systems, St. Elizabeth is only Kentucky hospital included
Staff report Becker’s Hospital Review has listed 22 health systems with strong operational metrics and solid financial positions, according to reports from credit rating agencies, Fitch Ratings and Moody’s Investors Service released in 2026. Included in the list is St. Elizabeth Medical Center in Edgewood which has an “AA” rating and stable outlook with Fitch....
‘No Kings Day’ protests against Trump administration expected in NYC
Organizers said it’s part of a mobilization to defend democracy and fight against authoritarianism.
NMSU public health professor to receive national health equity award
The Society for Public Health Education will bestow its 2026 Dorothy Nyswander Health Equity Award to Elizabeth England-Kennedy of New Mexico State University’s Department of Public Health...
Justice Department secures denaturalization of convicted gun trafficker and health care fraudster
The DOJ announced it secured the denaturalization of two criminals “who obtained U.S. citizenship through fraud" and sued to revoke the citizenship of a third.
Brenmiller Energy Issues Business Update Highlighting Commercial Breakthrough, First TES Revenue and BNRG360 Growth Strategy
Delivered flagship Tempo project, Brenmiller's first commercial-scale boiler replacement deployment, marking a major operational milestone in the Company's transition toward commercializationRecognized first revenue from a TES system sale, validating Brenmiller's ability to convert project execution into reported revenueEntering 2026 with previously disclosed projected 2026 revenue of approximately $1.7 million tied to Tempo execution milestones, which management believes reflects the beginning.
Michigan measles outbreak: Confirmed cases grow to seven, including child under 5
The Washtenaw County outbreak has seven confirmed cases and one hospitalization. Officials are asking that anyone unvaccinated or not already immune to measles stay away from others for a full 21 days after exposure.
Corus Entertainment Secures Court Approval For $363 Million Debt Plan
A fall in linear TV advertising and hefty borrowings led the major Canadian buyer of U.S. series like 'Survivor' and 'NCIS' to launch a recapitalization transaction to cut annual interest charges via a new parent, NewCo.
About 40 'No Kings' protests planned across Tennessee. See when and where
In total, organizers estimate about 3,000 events nationwide, surpassing previous 'No Kings' mobilizations since the movement gained traction on President Trump’s birthday in June 2025.
Brazil’s former president Bolsonaro allowed to serve 27-year sentence at home due to poor health
The decision follows Bolsonaro’s hospitalization for pneumonia, one of several health problems he has faced since he was stabbed by a man in 2018 before he was elected president.
Bolsonaro allowed to serve 27-year sentence at home due to ill health
The decision by Supreme Court Justice Alexandre de Moraes follows Bolsonaro’s hospitalization since March 13 for pneumonia.
Candle-Making Business Is the Latest Pop-Up to Join Downtown Revitalization Effort
Visitors on Saturday, March 28 can receive a free gift.
US democracy has settled into diminished state, experts find
Bright Line Watch researchers see stabilization in democratic health but at lower levels after sharp decline
Stealth BioTherapeutics Announces MRC Business Engagement Fund Grant to Advance Mitochondrial Disease Research
/PRNewswire/ -- Stealth BioTherapeutics (the "Company"), a commercial-stage biotechnology company focused on the discovery, development, and commercialization...
Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. 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