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We disagreed on politics. We agreed on wine. That was enough.
At the Virginia Governor’s Cup Gala in Richmond earlier this month, a very dapper gentleman approached me and introduced himself. In his light-colored suit and bowtie, he looked very Southern in a classical sense, the sort of Virginia Gentleman you used to see south of the Rappahannock as recently as my college days. “I’m a longtime reader and fan of your writing, if not your politics,” he said. His comment was the proverbial iron fist in a velvet glove, simultaneously conveying praise and disapproval while establishing boundaries. Man, I wish we still discoursed like this instead of shouting bromides and insults to try and “own” our opponents with a funny meme and a furrowed brow. Subscribe “Well, we’ll always have wine to share together,” I said, and thanked him for his kind words. We clinked glasses, exchanged pleasantries about the delicious gold medal-winning wines being poured that evening, and went our separate ways. Our exchange reminded me that more unites us than divides us. Wine brings people together to share a meal and a few hours of joy despite our differences.1 That’s why I refer to the wine community — including readers and consumers — rather than the wine industry. Together, we are so much more than production, distribution and sales statistics. A few minutes later the evening’s awards ceremony began. Applause grew as the 12 winemakers who made the top-scoring wines for the Governor’s Case took the stage, including a loud cheer for Jonathan Wheeler of Trump Winery and his 2018 Blanc de Noir sparkling wine. All the winemakers on stage had reason to be proud, Wheeler perhaps more so. Trump Winery was the only winery to win six gold medals in the competition this year. (Wineries are limited to six entries.) Two of Wheeler’s ciders also won gold medals in a separate competition. When you cover the labels and take the sour taste of politics off your palate, the wines are pretty darn good.2 Then Gov. Abigail Spanberger, newly elected Democrat and Virginia’s first female governor, was introduced to great applause to announce which of the 12 wines had won the Governor’s Cup. She spoke for a few minutes about the importance of wine to Virginia’s economy and tourism and the international acclaim Virginia wine has received. Just two weeks earlier, she gave the Democrats’ response to Trump’s State of the Union speech, but this night wasn’t about politics. That didn’t stop several people in the crowd from speculating on the irony should she have to present the trophy to Trump Winery. In the end, Valley Road Vineyards was displayed on the screen behind Spanberger as the winning winery. Blue Bee Cidery in Richmond took top honors for that category. The crowd cheered a female governor presenting the state’s highest trophy to a female winemaker and then resumed the evening’s festivities, united by their mutual love of wine. A whiff of politics couldn’t dim the cheer of celebration and a community united by its love of wine. In Memoriam: Michel Rolland The global wine community lost a giant March 20, with the passing of Michel Rolland. He was 78. Rolland was the original “flying winemaker,” a globe-trotting consultant who helped Bordeaux regain its mojo in the 1970s and then shaped the rise of Napa Valley cult Cabernet as consultant to Simi, Harlan, Newton, Screaming Eagle, Araujo, Dalle Valle and other wineries. He was instrumental in Argentina’s rise to prominence and even had his own winery, Clos de los Siete, in a partnership with other wine families. Rolland’s career arc paralleled that of Robert Parker, the world’s most influential critic. Parker championed many of the wines Rolland consulted on, helping build his reputation and demand for his services. It also made him a target for Parker’s critics. As W. Blake Gray wrote on Wine-Searcher in his excellent tribute to Rolland: Rolland created the type of wines Parker loved: rich body, plenty of fruit, soft tannins. He sometimes faced the accusation of creating a generic international style of red wine, where the great wines he made in Argentina were indistinguishable from the great wines he made in France. Rolland chafed at that critique, as did many of his fans. He was credited with championing green harvesting and leaf pulling, as well as careful selection of grapes in the winery, practices we nearly universally think of today for high-quality winemaking. “Michel was an incredible innovator who changed how wine was made and how grapes were grown,” Napa Valley winemaker Aaron Pott wrote on Facebook. “His work has transformed the wine trade. He created new ways of looking at wine, tasting wine, evaluating ripeness and quality. … This was not just a man with a ‘style’ that he imposed on vineyards but a man that understood how to make great wine from great sites.” Rolland started his consulting company in 1973 in Libourne, in Bordeaux, with his wife, Dany. Both had graduated the year before from Bordeaux’s Institute d’Oenologie. The couple sold their majority share in the business in 2020, according to Wine Spectator. Over his career, Rolland reportedly worked with more than 100 wineries in 20 countries. He even made it to Virginia, where he consulted for Kluge Estate in the mid-2000s. (Kluge Estate is now Trump Winery.) Reader feedback, please! Last week, I did my first WineLine Live! with Dr. Laura Catena of Catena Zapata winery in Argentina. We enjoyed a fascinating discussion about her efforts to preserve the genetic heritage of old vineyards in Mendoza. I conceived of WineLine Live! for paid subscribers, as a thank you for your financial support. And while only a few people joined live, the video now has more views than I have paid subscribers, so I guess that’s pretty good. Even so, I’m considering opening future installments to anyone on Substack to reach a broader audience. So my questions to you: Should these be public? And what format do you prefer? Live gives a chat feature with the potential for viewers to interact with me and the guest, while a video post would just be that. Another alternative is a podcast, which would just be audio, without video of my chins. Please let me know in the comments. Leave a comment In the Glass A few wines I’ve enjoyed recently: Bonny Doon Vineyard Take Me to Your Liter, Le Cigare Volant, Red Wine of the Earth. 2023, Central Coast, CA. Blend of Grenache, Syrah Cinsaut and Petite Sirah. Delightful wine with expressive red fruit flavors, casual drinking. Doon lovers of a certain age will remember Randall Grahm’s Big House Red; this is more in that style than his original Le Cigare Volant, modeled after Chateauneuf du Pape. The liter bottle makes it an even better value. I see this online at about $15. Great value. Albert Bichot Bourgogne Pinot Noir Origines 2023. 13% - Textbook pinot noir and an excellent, affordable entry (regional) Burgundy. Wine Enthusiast Top 100 Wines of 2025. $24 at Total Wine & More. Loma Larga Pinot Noir 2021 “Coastal Cool Climate Wine”, Valle de Casablanca, Chile. An older sample, showing beautifully. Spicy and fruit forward. I’m seeing widely varied pricing online, from $18-$32. At the lower end, it’s a terrific value. 13.5% Dr. Loosen Riesling Dry 2016, Mosel, Germany. Found this “in the stack.” And it stacked up well, shedding some of its youthful acidity for opulent Riesling character, including a hint of the mineral oil older Riesling often features. A great value, as I’m seeing it as low as $14 online. 12% abv. Red Tail Ridge Blau Franc Blend 2024, Sans Oak, Finger Lakes. 13.4% abv. The name is a neat portmanteau of Blaufrankisch and Cabernet Franc, thus Blau Franc. The blend is 50-50, no oak involved. The Blau dominates on the palate, with the spicy caraway seed (think New York deli rye bread). The Franc adds body. The result is juicy, energetic and joyful. Sokol Blosser Estate Rosé of Pinot Noir 2025, Dundee Hills, Willamette Valley, Oregon. This first rosé of 2025 was a welcome respite to our cold, snowy winter here in the Mid-Atlantic. Oh man, I needed this! Bright and energetic, exuberant even, it perks up the mood and goes down fast. 13%. Certified B Corp. Ingredient and nutrition labeling, and in a modest way that doesn’t occupy a lot of label space. (Since it’s not required, presumably there are no minimum font size requirements.) More wineries should follow this example. Dave McIntyre's WineLine is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Subscribe Thanks for reading Dave McIntyre's WineLine! This post is public so feel free to share it. Share 1 Some restraint may be required. 2 Especially the bubblies.
Welcome, American scientists: Europe, a haven for researchers struggling under Trump
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Your Thymus and Your Healthspan
Our thymus gland plays a central role in the development or our immune system, specifically for supporting T cell development (how these cells got their name, maturation and differentiation in the thymus) and discriminating between self and foreign, non-self antigen proteins with production of dendritic cells. As we age, our thymus gland shrinks—the process known as involution—with progressive change from spongy to fatty tissue, with loss of functionality. But this process, with respect to timeline and extent, markedly varies from one person to the next. And to make things even more complicated, our thymus gland anatomy and precise location in the chest also is highly variable. So the famous Frank Netter diagrams from the 1960s (such as at left below) don’t capture the remarkable heterogeneity that a random set of 12 chest CT scans (below at right). What I consider as 2 landmark papers in Nature this week (here and here) used AI to quantify health of the thymus in 2 large cohorts, and then correlate the metric to a broad array of health outcomes. In this edition of Ground Truths, I’m going to cover three questions: (1) How was thymus health determined by AI?; (2) How is thymus health linked to key clinical outcomes? and (3) Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? Subscribe 1. How was thymus health determined by AI? This was accomplished by extensive work developing and validating an AI pipeline for 2 stages, the first for localization and segmentation of the thymus bed, and the second to quantify a digital marker, termed the thymic health score. There’s a lot to this algorithmic development, so I won’t go into all the details, but just provide a rudimentary outline of what was done. The 1st stage used supervised learning with 2 radiologists reviewing 2,461 chest CT scans. That work trained a 3D U-Net model to automatically identify the thymic bed’s 3D cropped region using center of mass coordinates, which reached 99.8% accuracy. The 2nd stage used a foundation model that was pre-trained with SwAV (which stands for Swapping Assignment between multiple Views), a self-supervised model, that generated a high-dimensional thymus representation of 4,096 features. That compares to the radiology reductionist and subjective scoring of 0 to 3 where 0 means the thymus is fully degenerated and fatty, and 3 is considered dense, intact glandular soft tissue. Notably, the self-supervised learning (SSL) performance was superior to supervised (AUC ~0.75 vs 0.55, respectively) reflecting the shallowness of the 0-3 classifier vs SSL’s holistic, self-taught AI. The thymic health score ranged from 0 to 100, with the highest number indexed to fully preserved thymic health. The algorithmic work extended to explainability with both Shapely value distribution, meaning the model was holistic not relying on any “magic” pixel, and occlusion sensitivity, demonstrating the model’s performance was not affected by ribs, sternum, lung tissue, but rather focused on the thymic bed directly. Below are a few saliency maps from the occlusion sensitivity that indicate the thymic bed focus, not affected by neighboring structures, using the jet color scale. Now the AI was ready for processing ~25,000 CT scans, each over 30 MB files, from the 2 large participant cohorts to provide a thymic health score, it did so in less than 14 hours, which is less than 2 seconds per scan! Share 2. How is thymus health linked to key clinical outcomes? The two cohorts were the National Lung Screening Trial, NLST (N=25,031) and the Framingham Heart Study, FHS (N=2,581) each with baseline demographics and long term follow up of >12 years for health outcomes. From the NSLT, you can see below that increased age and body-mass index were correlated to reduced thymic health. And, overall, men had reduced thymic health scores compared with women. There are a lot of graphs in the paper for outcomes, for both the NLST and FHS cohorts. To simplify the major outcomes, below is a composite Figure with striking reduction of all-cause mortality and for the different causes of death. The results were consistent between the 2 cohorts. For example, the cardiovascular mortality hazard ratio average was 0.57 in NLST and 0.38 in FHS (weighted to be 0.53 for the aggregate). The reduction of mortality also extended to digestive diseases and pulmonary disease (data not shown below). Lung cancer incidence was reduced by 36% for high vs low thymic health (Figure below, with a panel -incidence and b panel-mortality, adjusted for age, sex, BMI, smoking status). Notably, there was a smoker’s paradox: lower incidence and improved survival for lung cancer in smokers who had a high thymus health score. Smoking was associated with lower thymic scores whereas alcohol was not. Higher thymic health was linked to higher HDL cholesterol, lower triglycerides, lower fasting blood glucose, and lower systolic and diastolic blood pressure. Inflammation biomarkers, such as C-reactive protein and interleukin-6, were elevated in the people with lower thymic health scores. In their second paper, the same team looked at the relationship between thymic score and outcomes for 3,476 patients receiving cancer immunotherapy. The non-small cell lung cancer progression-free survival was reduced in patients with low thymic health score. A parallel relationship for survival was seen for other types of cancer including melanoma, breast, and kidney with a 44% lower risk among high thymic scores (Figure). A similar pattern was seen with different immune checkpoint inhibitors. The thymus health score outperformed programmed death ligand-1 (PD-L1)and tumor mutation burden (TMB) assay of the tumor and was an independent prognostic marker of progression-free survival. In this dataset, a direct connect with thymus score and adaptive immune function was noted with a correlation before cancer treatment for both T-cell diversity and thymus T-cell production (a metric known as T cell receptor excision circles). Thymus Removal Study There is a highly relevant citation about thymus function before moving onto ways to rejuvenate it. In 2023, a very important study of thymus removal during cardiothoracic surgery was published, with 1146 patients undergoing thymus removal vs 1146 matched controls (mean age 55 years). The adverse outcomes for thymus removal were striking, with a 2.9 higher risk of all-cause mortality and doubling of cancer incidence, 1.5 fold increase in cancer mortality, and 1.5-fold increase in autoimmune diseases. The immune function showed marked compromise after thymus removal, as reflected by CD4+ and CD8+ T cells (Figure below) Share Ground Truths 3. Are there ways we can promote a healthy (aka rejuvenate) thymus gland in our later years? In recent months we’ve learned a lot about the process of thymus involution and the pathways by which this may be modulated. Thymus involution is primarily due to loss to thymus epithelial cells (TECs) and there are 2 subtypes with different functions: the cortical, responsible for positive selection of T cells, and the medullary, for negative selection. When adipose tissue infiltrates the thymus, thymic adipocytes are pro-inflammatory, knocking out T-cell output. Likewise, systemic inflammation, or “inflammaging,” from smoking, obesity, and chronic stress promote thymic adipocytes. Now, from preclinical studies, we know about key pathways that account for these processes. Historically, back in 2014, FOXN1 was recognized as a single master transcription factor essential for TEC function, with studies in mice with forced FOXN1 upregulation leading to thymus regeneration. That laid the foundation for potential regrowth of quiescent thymus cells. It took awhile to find pathways to accomplish this goal and to even refute its role as the master regulator. The Liver-Thymus Axis Feng Zhang and his team recently showed that injection of an mRNA vaccine to the liver encoding DLL1, IL-7 and FLT3-L in combination, factors known to support thymopoiesis (Figure), successfully enhanced immune function in aged mice. However, the effect was transient. The FGF21 Story Two reports in 2025 addressed the thymus gland’s production of FGF21, a growth factor (fibroblast growth factor 21) and its control of thymus involution. This growth factor is also produced by the liver, but it doesn’t have impact on the thymus in aged rodent models. In contrast, The liver’s hepatocyte growth factor (HGF) has been shown to reverse senescent TEC structural changes. Growth hormone stimulates production of insulin growth factor-1 (IGF-1) in the liver and the thymus. Two small studies in human participants (TRIIM, for Thymus Regeneration, Immunorestoration, and Insulin Mitigation) of 6 and 50 people, respectively, treated with combined human growth hormone, metformin and DHEA, suggested the potential of slowing epigenetic aging and improving thymus mass and function. But the combination of drugs, small sample, and lack of controls make conclusions murky. Increased thymus FGF21 led to increased CD8 T cells in old mice and extended healthspan and improved physical performance. Building on the previous FOXN1 data, ablation of β-klotho, the obligatory co-receptor for FOXN1, accelerated thymic aging. The benefit to FGF21 was confirmed in a companion paper using an FGF21 knock-in mouse model showing thymus enlargement and increased TECs throughout the lifespan. (schematic Figure below). The accompanying editorial for these 2 papers speculated: “The proposed link between age-associated thymus involution and organismal aging is intriguing, and suggests we might seek to achieve systemic rejuvenation by counteracting thymic involution.” Other Factors Lessons from the Axolotl (Mexican Salamander) In an elegant set of experiments of the axolotl (Figure), known for its complete thymus regeneration after total surgical removal, mediators were identified. Surprisingly FOXN1 was dispensable. But midkine, a growth factor, appeared to be the driver, the initiator of thymus cell growth, survival, and repair. Other components that contributed were Postn+ (periostin-expressing mesenchymal niches) and Ccl19, a chemokine protein from the bloodstream. RANK and RANKL RANK (receptor activator of nuclear factor κB its ligand (RANKL) have been considered key regulators of medullary TECs. In a study of both aged mice and human thymus cell cultures, their key role was confirmed, with multiple benefits of resorting TEC function, recruitment of progenitor cells, and T cell development. Subscribe Summing Up This body of work strongly supports the health of the thymus gland as a critical regulator of human healthspan, not just a correlate or link. The new landmark studies are reinforced by the regenerative biology experimental models that have shown, via an array of mediators, that healthspan of aged mice is at least in part dependent on thymus gland function and its critical role for maintaining adaptive immunity. It sure seems that we’d be better off having an immune reservoir of naive T cells instead of a profile in older adults of exhausted, low quality, memory T cells, with a senescent phenotype. It is striking that we ignored the importance of the thymus gland for many decades. A wake-up call was the results of the thymectomy matched control study reviewed here, with the opposite of high thymic health score improved health outcomes. The convergence of AI and healthspan here is notable. The exceptional and laborious work for developing and validating (no less explaining) the AI to quantify thymus health set the foundation for probing the connect the major health outcomes in two cohorts with extensive follow-up. We’ve never had a way to meaningfully quantify the thymus gland before, so this represents important leverage of supervised, self-supervised, and transformer models. The study wouldn’t have been possible without AI. And it begs the question as to whether there are ways we can maintain our thymus at a high health score. But it’s not so simple to rejuvenate our thymus. There are multiple risks including the induction of autoimmunity, increasing the risk of cancer, and inducing a pro-inflammatory state. For example, factors that increase TEC proliferation could compromise the medulllary negative selection process and leak out auto-reactive (self-attacking) T cells. Thymic cells could be induced to proliferate, but we know, for example, that growth hormone and IGF-1 are associated with an increase risk of cancer. If thymus rejuvenation doesn’t clear out the accumulated senescent cells in older adults, then inflammation within the gland could block the production of TECs. Keeping these risks in mind, we now have identified many ways to keep our thymus healthy as we age that undoubtedly will be tested in clinical trials going forward. Ultimately, the benefit-to-risk tradeoffs will be defined. In the meantime, we have desperately needed an immunome. As I’ve stressed in multiple prior Ground Truths, we have no test in the clinic to assess a patient’s immune status! It was very encouraging for me to get an email from Hugo Aerts, the senior author of the landmark papers in the days after they were published: “I also wanted to say that your Substack on “Why We Need an Immunome” was inspiring for this work. We found it a very compelling perspective and greatly enjoyed reading it.” Just having an assessment of a person’s immune status via a chest CT scan, with millions of these performed per year, might help in guiding the right immunotherapy for cancer (e.g. more intensive, combinations for those with low thymic health scores) and help define people who are increased risk for age-related diseases of cancer, cardiovascular, and neurodegenerative. The main theme of Super Agers is that we now have many layers of data (genetics, proteins, biomarkers, organ clocks that can be integrated via multimodal AI) for us to define a person’s specific risk decades before one of these age-related diseases leads to symptoms, enabling prevention. From the new studies this week, we can add thymus health score as yet another way to understand a person’s risk, a window into their adaptive immune system and healthspan. And perhaps someday we will be able to safely rejuvenate the thymus, or maintain its health through one’s life, and use the thymus health score to monitor. NB: I wrote this post (No A.I.) A Quick Poll Loading... ********************************************************************* Thanks to Ground Truths subscribers (now > 200,000) from every US state and 212 countries. Your subscription to these free essays and podcasts makes my work in putting them together worthwhile. Please join! If you found this interesting PLEASE share it! Share Ground Truths Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don’t hesitate to post comments and give me feedback. Let me know topics that you would like to see covered. Leave a comment Many thanks to those who have contributed—they have greatly helped fund our summer internship programs for the past two years. It enabled us to accept and support 47 summer interns in 2025! We aim to accept even more of the several thousand who will apply for summer 2026.
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A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO { "@context": "https://schema.org", "@type": "VideoObject", "name": "Downtown Road Closure Dilemma", "description": "A DOWNTOWN CHICO MERCHANT IS EXPRESSING CONCERN OVER THE IMPACT OF STREET CLOSURES FOR EVENTS -- ON THEIR BUSINESS. ACTION NEWS NOW REPORTER BELLA BARBOSA REPORTS FROM DOWNTOWN CHICO", "thumbnailUrl": "https://bloximages.newyork1.vip.townnews.com/actionnewsnow.com/content/tncms/assets/v3/editorial/c/47/c47e26d6-03c3-5f35-bf49-37925ab603d7/69bdedc4eb57d.image.jpg", "uploadDate": "2026-03-20T17:45:00-07:00", "contentUrl": "https://cdn.field59.com/KHSL/1774053903-6e1ef36dd09fbebf020833aee86b60da3b3cca3f_fl9-720p.mp4" } CHICO, Calif. - A downtown Chico business owner is voicing concerns about the impact of street closures for events on local shops. Leann Powell, owner of The Peddler’s Closet, expressed concern about events closing down streets downtown and bringing in food trucks and other shops’ products that directly compete with the brick-and-mortar stores in downtown Chico.Powell said an upcoming event held on a Saturday has brought up concerns for her and other business owners downtown, due to it being a busy day for businesses. "We're already struggling, and then to bring in more businesses on top of our businesses and shut our streets down is absolutely devastating," said Powell.Powell noted a decline in business during events like the Thursday Night Market, where street closures allow outside vendors to set up shop. She shared that while organizers for these types of events often offer booths to local businesses, it does not alleviate the burden."I don't really feel like that's a solution because you're bringing in other businesses, you're shutting the streets down. Yes, we can go down and set up a space, but then you've gotta pay somebody to run that space, plus run your own business for the day, and it's really not, it's really not helpful for us," said Powell.Applying for a street closure permit in Chico involves approval from the Public Works Department, the Chief of Police, and the Fire Chief. Permits can be denied only under a handful of circumstances, such as interference with first responders, previously scheduled construction, or existing permits for the same space.Mayor Kasey Reynolds addressed the issue, saying the city council has tasked staff with reviewing the municipal code for street closure permits with the goal of finding ways to minimize negative impacts on local businesses during events.Reynolds mentioned that any recommended changes might require further direction from the city council, depending on the extent of any changes recommended. googletag.cmd.push(function() { googletag.display('ad-1514992'); });
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If you are wondering whether Madison Square Garden Entertainment is still good value after its recent run, this article will walk through what the current share price might be implying. The stock closed at US$58.84, with a 1 year return of 84.7%, an 8.3% gain year to date, a 1.6% decline over the last 30 days, and a 6.8% decline over the last week, which may signal shifting views on its potential and risk. Recent coverage has focused on Madison Square Garden Entertainment as a live...
How The Times Tracks Down the Connections Behind Trump’s Pardons
Reporters tapped sources, combed through public records and scrutinized social media to penetrate the web of influence and money underlying the president’s clemency grants.
Your pre-ceremony watchlist: Oscar®-nominated movies now playing on Delta
Before the red carpet rolls out at the March 15 Oscars®, Delta customers can already be watching this year’s most talked-about nominated films, curated by the expert inhouse team behind Delta's in-flight entertainment. With thousands of seatback screens and live satellite TV on select aircraft, customers can build their watchlist or even tune in to the awards live while flying.
Everything Apple Announced This Week, From iPhone 17E to MacBook Neo
Devices have been flying out of Cupertino the past three days, and everything's up for preorder now. Here's what's new.
Antarctica Looks Like It’s Bleeding. Scientists Finally Figured Out Why.
The Blood Falls is the result of a complicated interaction in which overlying ice, underlying rock, and an ancient lake bed form a pretty unsettling natural display.
Fewer Canadian tourists visiting Las Vegas as politics, promotions shape travel trends
New data shows fewer Canadians are flying into Las Vegas to start the year, raising questions about how the political relationship between the United States and
Buchanan Street residents split over business restrictions from zoning
Buchanan Street neighbors and business owners are weighing the pros and cons of applying a new zoning tool that limits certain types of businesses.
Pritzker-owned bourbon company faces lawsuit alleging ‘pervasive gender bias’
A Kentucky bourbon maker that is part of the Pritzker portfolio is the target of a lawsuit alleging systemic sexism and a culture of bullying at the business.
Apple Discusses Google Hosting New Siri as Need for Cloud Help Grows
In January, when Apple announced an agreement to use Google’s Gemini models in Apple products, it was an admission that the iPhone maker hasn’t been able to compete in AI on its own over the past couple years. But the deal also showed that Apple is again relying on an outside company to help it ...
Talking Trash: Avoid Penalties on Cross-Border Business Aircraft Flights
There are strict rules for properly dealing with refuse when flying back into the U.S. Experts say breaking the law risks stiff fines and even prison sentences.
Talking Trash: Avoid Penalties on Cross-Border Business Aircraft Flights
There are strict rules for properly dealing with refuse when flying back into the U.S. Experts say breaking the law risks stiff fines and even prison sentences.
Inside the competitive business of flying political candidates
Gregg Brunson-Pitts' company specializes in campaign travel and has worked with prominent figures like Joe Biden, Ron DeSantis, and Kamala Harris.
Inside the competitive business of flying political candidates
Gregg Brunson-Pitts' company specializes in campaign travel and has worked with prominent figures like Joe Biden, Ron DeSantis, and Kamala Harris.
Tailspin Ale Fest returns with new entertainment, new businesses, hundreds of beers
The 13th annual Tailspin Ale Fest is set for Saturday, March 7 at historic Bowman Field, bringing more than 250 beers, live entertainment, food trucks and new high-flying surprises.
Textbooks challenged by new discovery about how cells divide
Scientists have uncovered a surprising new way that giant embryonic cells divide—without relying on the classic “purse-string” ring long thought essential for splitting a cell in two. Studying zebrafish embryos, researchers found that instead of forming a fully closed contractile ring, cells use a clever “mechanical ratchet” system.
Is PENN Entertainment (PENN) Attractively Priced After Recent 20% Weekly Share Price Jump?
Wondering whether PENN Entertainment at around US$15.64 is a bargain or a value trap? This article walks through what the current price might be implying. The share price has moved sharply in the short term, with a 20.1% return over the last 7 days and 18.0% over the last 30 days. However, the 1 year return of 27.3% and 3 year return of 49.8% show a very different picture. These swings come as investors continue to reassess PENN Entertainment's position in the US gaming and entertainment...
What it was like flying overseas with my baby for the first time; tips
Flying internationally with a baby was intimidating, but meticulous planning, studying airline rules, and having low expectations made it manageable.
Supreme Court tariff ruling: a welter of new uncertainties
The decision is a vindication for the rule of law, but Donald Trump will not take the verdict lying down
Medicare spending set to nearly double in 10 years and Medicaid and ACA spending up a third, CBO says, just as Trump’s tax cut shortens its lifespan
Medicare spending alone will nearly double over the next decade, but the CBO projects its underlying trust fund will run dry by 2040.
Galaxy S26 ‘Now Nudge’ is basically Google Pixel’s Magic Cue, but you’re forced to use Samsung Keyboard
Samsung is completely changing directions this year, and among moves like adding Perplexity as an AI assistant instead of relying...
Exclusive | Spy Agency Blocks Congress From Seeing Gabbard Whistleblower Intelligence
Tulsi Gabbard’s office rejected Democratic efforts to see all the underlying material about a foreign conversation that discussed Jared Kushner.
Lowe’s Sales Rise on Pro Builder Business Growth
Lowe’s reported higher fourth-quarter sales as continued growth in its business supplying professional builders helped it to offset weakness in the home improvement market.
Trump issues patriotic rallying cry as he faces tough political headwinds
The BBC's Anthony Zurcher was in the chamber as the US president delivered a lengthy sales pitch to the nation.
Raymond James double upgrades this auto parts distribution ahead of planned business separation
Raymond James sees shares of Genuine Parts Company rallying 25% from here.
Punch the sad viral TikTok monkey sends Ikea plush sales soaring
A viral baby monkey hugging an Ikea plush has sent the $19.99 toy flying off shelves and surging on resale sites.
Uniting to respond to mental health impacts of digital violence
Technology-facilitated gender-based violence (TFGBV), from doxxing and cyberstalking to cyberbullying and online harassment, is reshaping how women and girls navigate digital spaces. Globally, an estimated 23% of women have experienced digital violence. In Indonesia, reported cases of TFGBV reached 1,791 in 2024, a 40.8% increase from the previous year. Yet very few survivors seek help, leaving lasting effects on their mental health and wellbeing. As part of the multi-UN agencies UNiTE campaign for the 16 Days of Activism against Gender-Based Violence, the World Health Organization (WHO) and the Ministry of Health (MoH) co-hosted a talk show on 6 December 2025 to spotlight this urgent issue. The event brought together voices from Meta, the Indonesian Clinical Psychologist Association and Dr Vivi Syarif, a WHO Fides content creator, creating a cross-sectoral dialogue on the magnitude and mental health impact of digital violence. The talk show introduced psychological first aid as a vital initial intervention that communities can provide to survivors. This intervention aligns with the Psychological First Aid: Guide for Field Workers, a framework that has been standardized for over a decade. The "look, listen, link" approach focuses on ensuring safety and urgent needs, reassuring survivors and connecting them to appropriate services. In addition to this public health approach, Meta also outlined mechanisms to respond to digital violence and reaffirmed its commitment to building safer digital spaces by continuously updating community guidelines based on user feedback. Such collaborative discussions help connect community engagement initiatives with daily digital life. They empower audiences not only to understand how the health sector and industry are responding, but also to educate others, promote first-line support and encourage referrals to appropriate help. By fostering awareness and engagement, these dialogues strengthen collective resilience against digital violence. Written by Jessie O. Yunus, National Professional Officer (Gender, Equity, Rights and Disability Inclusion), WHO Indonesia
Missouri City woman says a trademark dispute is hurting her wings business
A Missouri City woman reached out to ABC13, upset by what she calls bullying from the master planned community where she lives and owns a business.
Business Lookahead: Nvidia earnings take center stage
STORY: As global markets react to the U.S. Supreme Court ruling on President Trump's tariffs, Nvidia earnings head for center stage. These are the stories to watch in business and finance in the coming week. :: Nvidia's momentMarkets will be watching for Nvidia's quarterly results Wednesday...as investors worry about returns on AI spending and industry disruptions caused by the emerging tech.Nvidia shares have soared following the launch of ChatGPT in late 2022.But shares of the company and others in the "Magnificent Seven" have stalled so far in 2026.:: Anniversary angstTuesday marks the four-year anniversary of Russia's full-scale invasion of Ukraine.While the push for a ceasefire continues, getting one over the line remains difficult.Ukraine has faced sustained pressure to agree to a deal that could mean painful concessions, as Russian forces pound its power grid and slowly advance on the battlefield.The International Monetary Fund looks set to rubberstamp extended support, meaning Kyiv's bonds are flying high.:: Key Australia dataAustralia's consumer price reading Wednesday will be closely watched by investors, who are betting the central bank will hike rates at least once more this year.Earlier this month, Australia's central bank became the only one in the G10 outside Japan to tighten policy, as it struggles to bring inflation under control in a supply-constrained economy.:: British uneaseBritish Prime Minister Keir Starmer faces a reckoning Thursday in a Manchester special election.Investors will be watching the results closely. Friday could be another volatile day for British markets and Westminster.British gilts and the pound wobbled earlier this month as a crisis engulfed Starmer over what he knew of Peter Mandelson's links to late sex offender Jeffrey Epstein when he appointed the former as U.S. ambassador.
Client Relationship Retention and Steady Sales Momentum Make Jack Henry & Associates (JKHY) a Resilient Business
Conestoga Capital Advisors, an asset management company, released its fourth-quarter 2025 investor letter. As many believe, US equities experienced solid returns in 2025, with double-digit gains across all major indices, yet underlying conditions revealed extreme volatility and market leadership. A copy of the letter can be downloaded here. In Q4 2025, Conestoga Capital Advisors SMid Cap Strategy […]
How I created a $20 million luxury ice company
Former bartender Richard Boccato now runs a $20 million ice business in Queens, supplying customized ice cubes to NYC's top bars and restaurants.
It’s Not Just Your Screens: Why So Many People Suddenly Need Reading Glasses
A new study suggests that dim lighting may be the underlying reason behind the surge in nearsightedness.
NASA fired three rockets into the northern lights and the results are stunning
NASA has pulled off a high-flying aurora investigation, launching three rockets into the glowing northern lights over Alaska. One mission targeted mysterious dark patches called black auroras, while the twin GNEISS rockets created a 3D scan of the aurora’s electrical currents. All rockets reached their planned altitudes and returned strong data. The result: an unprecedented look at how these dazzling light shows are wired from space to sky.
Welcome to Singapore's hustle economy
20-hour kitchen days. Tears and budget fears. Lying flat is the last thing on these young Singaporean business owners' minds.
Trump pushes hard on Iran and Ukraine deals
President Donald Trump addressed his hopes for constructive talks with Iran and Ukraine while flying back to Washington aboard Air Force One.
BHP Group's first-half profit jumps 22% on higher commodity prices
BHP Group on Tuesday reported a better-than-expected half-year underlying profit, driven by record first-half iron ore production and higher prices for its key commodities, iron ore and copper.
Business Beat: Tyler’s Twelve Kitchen plans expansion to Longview - Longview News-Journal
A popular Tyler restaurant is planning to expand to Longview at the former location of Flying Burger and Seafood. Twelve Kitchen + Cocktails has filed information with the Texas Department […]
Parkview: COVID-19 pandemic had created new molds, standards for healthcare
While people lives their lives mostly maskless today, some practices adapted to pandemic times have integrated within daily healthcare, and others pandemic-age practices are lying in wait for the p…
Is Sphere Entertainment (SPHR) Pricing Reflect Lofty Expectations After Las Vegas Sphere Buzz?
If you are wondering whether Sphere Entertainment's share price matches its underlying worth, you are not alone. This article is designed to help you frame that question clearly. The stock last closed at US$115.70, with returns of 24.1% over 7 days, 17.8% over 30 days, 22.7% year to date and 140.0% over 1 year. These figures naturally raise questions about how much future upside or downside is already reflected in the price. Recent coverage has focused on Sphere Entertainment's high profile...
“Smart Business” or “Bullying.” Taylor Swift Just Shut Down a “Swift Home” Trademark
Taylor Swift moved to block a bedding company’s “Swift Home” trademark. Within days, Cathay Home Inc. abandoned its federal trademark application. Swift’s team argued the ... Read More
MRN BUSINESS SPOTLIGHT: Refreshment Services Pepsi
On today’s Business Spotlight, Tim Schrage from Refreshment Services Pepsi joins Ron to talk about the recent shift in soda preferences among consumers. Lightly carbonated, no-sugar drinks like Alani are flying off the shelves, and he also introduces Poppi- a Shark Tank success that’s being called part of the next generation of sodas that are...
Hemp businesses rally against Chicago’s upcoming ban
Chicago’s upcoming ban on intoxicating hemp products has business owners rallying for a mayoral veto, warning it will shut down small businesses, cost jobs and disproportionately impact minority-owned establishments.
Earthquake data provide solid footing for AI foundation science model
There's been a seismic shift in science, with scientists developing new AI tools and applying AI to just about any question that can be asked. Researchers are now putting actual seismic waves to work, ...
Politics Seep Into Olympics After Ukrainian Banned Over a Helmet
Lying face-down on a flat sled, ready to lunge head-first down an ice track, skeleton athlete Vladyslav Heraskevych wore a helmet during his training sessions for the Winter Olympics featuring images of fellow Ukrainians who had died during Russia’s invasion of his country.
Is It True That American Airlines’ Flagship Suites Cost Less Than Flagship Business?
The carrier's latest product prices interestingly.
New rule to bar green card holders from US Small Business Administration loans
A new rule by President Donald Trump's administration will bar green card holders from applying for U.S. Small Business Administration loans and limit SBA loan eligibility to citizen-owned businesses, an SBA notice showed.
New Trump administration rule will bar green card holders from applying for SBA loans
The new rule, which goes into effect March 1, says only firms owned by citizens or U.S. nationals will qualify for Small Business Administration loans.
What SBA’s barring green card holders from business loans means for WMass
The SBA announced last week that all business owners applying for its loan programs must either be citizens or U.S. nationals.
Albany County legislation would limit cooperation with ICE
The county legislature says it introduced two new resolutions. However, lawmakers say this will not prevent agencies from complying with federal immigration laws.
BP reports fourth-quarter 2025 profits in line with expectations
BP posted a fourth-quarter underlying replacement cost profit, or adjusted net income, of $1.54 billion on Tuesday, compared with expectations of $1.55 billion in a company-provided poll of analysts and $1.17 billion a year ago.
Catherine O'Hara died from a pulmonary embolism. Cancer was the underlying cause
Rectal cancer was the long-term cause
Highly anticipated cyberpunk platformer Replaced gets demo, and you can play it this week
A demo of Sad Cat Studios' cyberpunk platformer Replaced has been announced.
I flew on Europe's best airline for business class and food; review
You don't usually expect restaurant-style service at 35,000 feet — but Turkish still staffs a 'flying chef' in business class on its longest routes.
How Recent Developments Are Reframing The Story For Accel Entertainment (ACEL)
Accel Entertainment’s latest research update keeps the fair value target anchored at US$15.17 per share, even as the underlying model inputs around discount rate and long term revenue growth are refreshed. Bullish and cautious analysts alike are treating this steady target as a test of how closely the company’s actual execution will track the assumptions behind that US$15.17 figure. If you want to keep on top of how this narrative evolves from here, stay tuned for ways to follow the key...
Why this rust-like mineral is one of Earth’s best carbon vaults
A common iron mineral hiding in soil turns out to be far better at trapping carbon than scientists realized. Its surface isn’t uniform — it’s a nanoscale patchwork of positive and negative charges that can grab many different organic molecules. Instead of relying on a single weak attraction, the mineral uses several bonding strategies to hold carbon tightly in place. This helps explain how soils store enormous amounts of carbon for the long term.
'Overwatch' just hit its highest player base on Steam PC since launch — passing Battlefield 6 and Call of Duty
All it needed was a flying kitty. Overwatch is so back, as the kids say.
Former Dodgers star Yasiel Puig convicted of federal charges in sports betting case
Former Dodger Yasiel Puig was found guilty of lying to investigators about his involvement in illegal sports betting and obstructing justice.
Integris Health and United Healthcare dispute leaves patients worried in Oklahoma City
Integris Health and United Healthcare are in a dispute that could leave many patients without in-network care, causing concern among those relying on Integris facilities.
A drop in CDC health alerts leaves doctors 'flying blind'
Doctors and public health officials are concerned about the drop in health alerts from the Centers for Disease Control and Prevention since President Trump returned for a second term.
Longevity expert shares his daily routine for wellness: I'm 'really intentional' about applying my research to my life
After studying longevity for decades, Matt Kaeberlein says he's applying what he's learned to his own life and habits. Here's his daily routine for wellness.
Grounded in business, soaring in aviation: The legal mind behind DFW Airport’s Expansion
Eliane Rodriguez has spent 14 years as the general counsel at DFW International Airport, a fast-flying entity with complex legal challenges.
Lakers rally to beat Sixers despite Doncic injury
The Los Angeles Lakers shook off the early exit of injured star Luka Doncic on Thursday, rallying without him in the second half for a 119-115 NBA victory over the Philadelphia 76ers.LeBron James scored 17 points and handed out 10 assists for Los Angeles, who halted the 76ers' five-game winning streak.
SBA to bar green card holders from applying for small business loans
The Small Business Administration said in a policy note that green card holders won't be allowed to apply for SBA loans, effective March 1.
Unvaccinated baby dies of measles in 15th case since outbreak began, Health Ministry says
Out of the previous 13 deaths, the majority were otherwise healthy babies with no underlying conditions who had not been vaccinated.
New Mexico solar firms hope tax credit hike will help boost business
With the expiration of a federal tax credit, installation companies are feeling the strain. Customers are relying more heavily on state aid.
Capital Allocation Trends At Elevance Health (NYSE:ELV) Aren't Ideal
If we want to find a potential multi-bagger, often there are underlying trends that can provide clues. Typically, we'll...
Nicki Minaj says 'bullying' of Trump propelled her into politics
Nicki Minaj made an appearance on "The Katie Miller Podcast," which airs on Tuesday, Feb. 3.
Flamigo in Pokémon GO Meta: Is It Worth the Grind?
Flamigo's raid attacker stats disappoint despite solid Flying and Fighting moves. Shines as spice in PvP in Great and Ultra League.
Does Colorado have too high of a population?
I think I first fell in love with Colorado back in 1968, when we took a family vacation from Michigan out to Salt Lake City and back. My dad had been asked to speak at a genealogy event, and rather than him just flying to SLC and back, we loaded up the station wagon (one […]
Nicki Minaj says Trump bullying pushed her into politics as MAGA supporter
Since aligning herself with the Trump administration, Minaj has garnered blow back from prominent voices in the entertainment industry.